Endocrine Abstracts

Vasoinhibin, historically also known as 16K PRL, is a peptide hormone with antiangiogenic, antivasodilatatory, and antivasopermeability effects generated by proteolytic cleavage of prolactin (PRL). The discovery of its role in diabetic retinopathy and peripartum cardiomyopathy led to the development of new pharmacological treatments and their evaluation in clinical interventional trials (ClinicalTrials.gov Identifier: NCT03161652 and NCT00998556). Recent insights into the func...

Context: Cytochrome P450 (CYP) 17A1 is located at major branch points of steroidogenesis exerting two distinct catalytic activities: 17α-hydroxylase generates glucocorticoid precursors and 17,20-lyase generates the principal sex steroid precursor dehydroepiandrosterone (DHEA). CYP17A1 deficiency (17OHD) is a rare form of congenital adrenal hyperplasia. In severe 17OHD, affected individuals typically present with both glucocorticoid and sex steroid deficiency and mineraloc...

The tumors of the thalamic-hypothalamic-pituitary system (diencephalon region, DR) include a fairly large group. These are pituitary adenomas, craniopharyngiomas (CP), pineal tumors, gliomas, meningiomas, and others. Tumors differ in the location, histological structure, and manifestations of the clinical picture with the corresponding hormonal changes, approaches and methods in treatment. Psychopathological symptoms are revealed in the symptoms of lesion of the DR in addition...

Stem cell transplants are used to treat and cure many types of haematological malignancies as well as rare solid-organ tumours. The conditioning regimes, medications and potential graft vs host disease can have effects on many organ systems in the body. The Endocrinology Department has designed a follow-up service over the past 3 years for patients in remission due to increasing awareness of the potential endocrinological and metabolic effects of allogenic stem cell transplant...

Patient- and family center edendocrine cancer care encourages active collaboration between the departments of endocrinology, oncology, surgery, pathology, chemistry, radiology, nuclear medicine and clinical genetics. The implementation of high-throughput DNA/RNA sequencing platforms has allowed novel molecular information to be used to optimize primary endocrine cancer care including tumor classification, prognostic forecasting, stratification for targeted treatment in recurre...

Introduction: An aim of the ERNs is empowering patients, by education & learning about their experiences after diagnosis of a rare endocrine disease (RED), to identify gaps and improve outcome. Thus, EndoERN Work Package 4 designed a survey, to learn about patients perceptions on quality of care and existing gaps in diagnosis/management.Aim: Evaluate results of a 21 question survey answered on-line on a Likert scale by individual patients with RED or...

Background: Guillain-Barré syndrome is a rare but very serious autoimmune disorder and it’s caused by the immune led demyelination of the peripheral nervous system. The symptoms are mainly weakness and numbness, but can also consist in severe respiratory failure due to paralysis. The treatment consist in administration of intravenous immunoglobulins (IVIGs) which shorten the duration of disease.Case presentation: A 67 year-old m...

Background: Conversion rates of the presentations into publications could be a measure of the scientific Impact of a conference. The aim of the current study was to determine the publication rates of abstracts presented at the 16th European Congress of Endocrinology (ECE 2014) and the factors affecting these rates by using computer algorithms specially coded for this analysis.Methods: All presentations of the ECE 2014 were collected with the web scraping...

Neurons expressing the agouti-related protein (AgRP) and the pro-opiomelanocortin (POMC) are part of the central system responsible for regulating energy balance and food intake. The hypothalamus is sensitive to changes in the inflammatory state. Either high-grade inflammation (e.g., caused by sepsis) or low-grade inflammation (caused by obesity) disturbs the hypothalamic function via inflammatory cytokines. Understanding how these cytokines interact and regulate the circuits ...

Objective: Self-reported volume of patients and specific interventions is a specific network criterion that needs to be fulfilled by reference centres that are eligible for inclusion within Endo-ERN. The aim of the present study is to evaluate how self-reported volume data in the original applications were obtained, which data are retrievable, and which set is best suitable to use for future centre evaluations. This overview is provided for two Main Thematic Groups (MTGs) of E...

Aim: To evaluate the current service provisions and provide action plan for improvement within the YAE service.Methods: A friends and family questionnaire given to all patients attending the YAE service from October 2018 – January 2019. Survey questions included: whether they thought this was a good clinic for friends and family to be looked after in, what we did well and what we could do better. For YA patients transferring from children’s s...

Neurofibromatosis type 1 is a genetic multisystemic disorder involving the skin, the central and peripheral nervous systems, bones, and the cardiovascular and endocrine systems. We report 2 cases of type 1 neurofibromatosis in 2 patients aged 27 and 23 years respectively. The dermatological lesions (neurofibroma and café au lait spots) were the revealing symptoms. Cerebral MRI revealed a glioma of the optic chiasm developing along the Optic nerves. NF1 has been known for ...

Background: Endocrine system (ES) is unique amongst all organ systems (OS) in human body. ES is a conglomeration of different endocrine organs. So far, the only models of proof o fintegrity within ES are APUD cell concept; HPA axis; HPG axis; biochemical pathways of hormones. But, the flaws in the above models are their presumptive and extrapolative nature. We wanted to test a model that every endocrine disease has collateral effect on other endocrine organs. We took nontoxic ...

Introduction: Autoimmune polyglandular syndrome (APS) is a rare disease, that is defined by the presence of two or more glandular insufficiencies caused by autoimmune mechanisms and that may be associated with other pathologies and immunological phenomena. It is characterized by the Presence of circulating organ specific antibodies and lymphocytic infiltration of the affected gland.Case report: A 38-year-old female known to have autoimmune polyglandular ...

Adult endocrine specialist nursing (ESN) is a highly specialised role and in recent years nurses have expanded their roles according to local need (Kieffer.V, et al. 2015). As an Endocrine team we review our practice, striving to provide the highest standard of research based, patient centred care. This involves ensuring the best use of resources and service provision in an ever more demanding environment. A new initiative lead by the ESN with consultant supervision w...

Autoimmune polyglandular syndromes (APS) are a rare group of autoimmune disorders that affect more than one endocrine gland, although non-endocrine organs can be involved. Concerning the variable evolution of this clinical entity over time, our case aims to emphasise the importance of regular follow-up and screening for polyglandular autoimmunity in selected patients in order to decrease a possibility of future complications consistent with APS. We report the case of a 20-year...

Prostate and seminal vesicles are male accessory sex glands secreting fluids that, together with sperm, form the semen. Clear evidence indicating these organs depend on androgens was found the men suffering hypogonadism because, in them, the function of these glands decreases markedly. Because prostate and seminal vesicles are androgen-dependent organs, they have been used as a model to test antiandrogenic drugs in different animal species.The objective ...