Searchable abstracts of presentations at key conferences in endocrinology
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22nd European Congress of Endocrinology

05 Sep 2020 - 09 Sep 2020

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Europe's leading endocrinology congress showcasing the very best in the study and treatment of endocrine disorders.

Audio ePoster Presentations

General Endocrinology

ea0070aep543 | General Endocrinology | ECE2020

Vasoinhibin dimerization and measurement in human sera with a new vasoinhibin elisa

Triebel Jakob , Müller Nils , Ebnet Johannes , Neugebauer Leon , Harris David , Friedrich Christin , Markl-Hahn Hülya , Pablo Robles Juan , Zamora Magdalena , Martínez de la Escalera Gonzalo , Clapp Carmen , Bertsch Thomas

Vasoinhibin, historically also known as 16K PRL, is a peptide hormone with antiangiogenic, antivasodilatatory, and antivasopermeability effects generated by proteolytic cleavage of prolactin (PRL). The discovery of its role in diabetic retinopathy and peripartum cardiomyopathy led to the development of new pharmacological treatments and their evaluation in clinical interventional trials ( Identifier: NCT03161652 and NCT00998556). Recent insights into the func...

ea0070aep544 | General Endocrinology | ECE2020

Expanding the clinical and genetic spectrum of 17α-Hydroxylase/17,20-Lyase deficiency: 7 cases and 5 novel mutations in the CYP17A1 gene

Sun Min , Müller Jonathan , Gilligan Lorna , Taylor Angela , Shaheen Fozia , Cheetham Tim , Denvir Louise , Gleeson Helena , Shenoy Savitha , Szarras-Czapnik Maria , Rahman Mushtaqur , Taylor Norman , T’sjoen Guy , Shackleton Cedric , Arlt Wiebke , Idkowiak Jan

Context: Cytochrome P450 (CYP) 17A1 is located at major branch points of steroidogenesis exerting two distinct catalytic activities: 17α-hydroxylase generates glucocorticoid precursors and 17,20-lyase generates the principal sex steroid precursor dehydroepiandrosterone (DHEA). CYP17A1 deficiency (17OHD) is a rare form of congenital adrenal hyperplasia. In severe 17OHD, affected individuals typically present with both glucocorticoid and sex steroid deficiency and mineraloc...

ea0070aep545 | General Endocrinology | ECE2020

Mental disorders in adult patients with diencephalon lesions by craniopharyngiomas.

Sidneva Yuliya , Astafyeva Ludmila , Zaitsev Oleg , Urakov Sergey , Kalinin Pavel , Kutin Maxim , Kadashev Boris , Shkarubo Aleksey , Fomichev Dmitry , Andreev Dmitry , Sharipov Oleg , Voronina Irina , Abdulatipov Shukur , Chernov Iliay

The tumors of the thalamic-hypothalamic-pituitary system (diencephalon region, DR) include a fairly large group. These are pituitary adenomas, craniopharyngiomas (CP), pineal tumors, gliomas, meningiomas, and others. Tumors differ in the location, histological structure, and manifestations of the clinical picture with the corresponding hormonal changes, approaches and methods in treatment. Psychopathological symptoms are revealed in the symptoms of lesion of the DR in addition...

ea0070aep546 | General Endocrinology | ECE2020

Late effects of allogeneic stem cell transplants on the endocrine and metabolic systems

Ng Nicholas , Moloney David , Healy Marie-Louise

Stem cell transplants are used to treat and cure many types of haematological malignancies as well as rare solid-organ tumours. The conditioning regimes, medications and potential graft vs host disease can have effects on many organ systems in the body. The Endocrinology Department has designed a follow-up service over the past 3 years for patients in remission due to increasing awareness of the potential endocrinological and metabolic effects of allogenic stem cell transplant...

ea0070aep547 | General Endocrinology | ECE2020

Joining forces in endocrine cancer genetics

van der Tuin Karin

Patient- and family center edendocrine cancer care encourages active collaboration between the departments of endocrinology, oncology, surgery, pathology, chemistry, radiology, nuclear medicine and clinical genetics. The implementation of high-throughput DNA/RNA sequencing platforms has allowed novel molecular information to be used to optimize primary endocrine cancer care including tumor classification, prognostic forecasting, stratification for targeted treatment in recurre...

ea0070aep548 | General Endocrinology | ECE2020

Patient perception and views on quality of care for rare endocrine diseases. Results from an EndoERN survey

Webb Susan , Kristensen Jette , Vitali Diana , van Klink Sandra , van Beuzekom Charlotte , Nordenström Anna

Introduction: An aim of the ERNs is empowering patients, by education & learning about their experiences after diagnosis of a rare endocrine disease (RED), to identify gaps and improve outcome. Thus, EndoERN Work Package 4 designed a survey, to learn about patients perceptions on quality of care and existing gaps in diagnosis/management.Aim: Evaluate results of a 21 question survey answered on-line on a Likert scale by individual patients with RED or...

ea0070aep549 | General Endocrinology | ECE2020

True hyponatremia – An unusual side effect of IV Immunoglobulins

Daniela Aflorei Elena , Jane Bracken Amanda , Stanciu Roxana , Tanase Dan , Kong Ngai

Background: Guillain-Barré syndrome is a rare but very serious autoimmune disorder and it’s caused by the immune led demyelination of the peripheral nervous system. The symptoms are mainly weakness and numbness, but can also consist in severe respiratory failure due to paralysis. The treatment consist in administration of intravenous immunoglobulins (IVIGs) which shorten the duration of disease.Case presentation: A 67 year-old m...

ea0070aep550 | General Endocrinology | ECE2020

Publication outcome of abstracts presented at European Congress of Endocrinology via web scraping and automated searches

Sedar Saygili Emre , Okan Yildiz Bulent

Background: Conversion rates of the presentations into publications could be a measure of the scientific Impact of a conference. The aim of the current study was to determine the publication rates of abstracts presented at the 16th European Congress of Endocrinology (ECE 2014) and the factors affecting these rates by using computer algorithms specially coded for this analysis.Methods: All presentations of the ECE 2014 were collected with the web scraping...

ea0070aep551 | General Endocrinology | ECE2020

TNF-α induces hyperpolarization in agrp neurons without affecting pomc neurons of the arcuate nucleus

Chaves Fernanda , Frazao Renata , Donato Junior José

Neurons expressing the agouti-related protein (AgRP) and the pro-opiomelanocortin (POMC) are part of the central system responsible for regulating energy balance and food intake. The hypothalamus is sensitive to changes in the inflammatory state. Either high-grade inflammation (e.g., caused by sepsis) or low-grade inflammation (caused by obesity) disturbs the hypothalamic function via inflammatory cytokines. Understanding how these cytokines interact and regulate the circuits ...

ea0070aep552 | General Endocrinology | ECE2020

The extent of variation in the reporting of clinical activity by reference centres in the field of rare pituitary and thyroid disorders within Endo-ERN, a new reference network for rare endocrine conditions in Europe

de Vries Friso , Bruin Mees , Cersosimo Angelica , Ahmed Faisal , Peeters Robin , Biermasz Nienke , Hiort Olaf , Pereira Alberto

Objective: Self-reported volume of patients and specific interventions is a specific network criterion that needs to be fulfilled by reference centres that are eligible for inclusion within Endo-ERN. The aim of the present study is to evaluate how self-reported volume data in the original applications were obtained, which data are retrievable, and which set is best suitable to use for future centre evaluations. This overview is provided for two Main Thematic Groups (MTGs) of E...

ea0070aep553 | General Endocrinology | ECE2020

‘I would say this is a good clinic for friends & family to be looked after in if they need similar treatment or care’ – Young Adult Endocrine (YAE) Service Evaluation

Feliciano Chona , Gleeson Helena , Toogood Andrew

Aim: To evaluate the current service provisions and provide action plan for improvement within the YAE service.Methods: A friends and family questionnaire given to all patients attending the YAE service from October 2018 – January 2019. Survey questions included: whether they thought this was a good clinic for friends and family to be looked after in, what we did well and what we could do better. For YA patients transferring from children’s s...

ea0070aep554 | General Endocrinology | ECE2020

Neurofibromatosis type 1: About two cases

Bouzid Aicha , laloui amina , Meskine Djamila , Azzoug Said

Neurofibromatosis type 1 is a genetic multisystemic disorder involving the skin, the central and peripheral nervous systems, bones, and the cardiovascular and endocrine systems. We report 2 cases of type 1 neurofibromatosis in 2 patients aged 27 and 23 years respectively. The dermatological lesions (neurofibroma and café au lait spots) were the revealing symptoms. Cerebral MRI revealed a glioma of the optic chiasm developing along the Optic nerves. NF1 has been known for ...

ea0070aep555 | General Endocrinology | ECE2020

Invivo endocrine internet: An unique model of endocrine system

Bhargav Panchangam Ramakanth , Bangaraiahgari Ramesh , Mohammad Rafi , Mayilvaganan Sabaretnam , Bangaraiahgari Rajesh , Reddy Banala Rajkiran

Background: Endocrine system (ES) is unique amongst all organ systems (OS) in human body. ES is a conglomeration of different endocrine organs. So far, the only models of proof o fintegrity within ES are APUD cell concept; HPA axis; HPG axis; biochemical pathways of hormones. But, the flaws in the above models are their presumptive and extrapolative nature. We wanted to test a model that every endocrine disease has collateral effect on other endocrine organs. We took nontoxic ...

ea0070aep556 | General Endocrinology | ECE2020

Autoimmune polyglandular syndrome (APS) type 2 associated with chronic kidney disease

El Ebrashy Ibrahim , ElHaddad Hemmat , Moustafa Heba , El Rawi Hoda , Amin Samar , Taraby Aya , Salam Randa , Magdi Mohamed

Introduction: Autoimmune polyglandular syndrome (APS) is a rare disease, that is defined by the presence of two or more glandular insufficiencies caused by autoimmune mechanisms and that may be associated with other pathologies and immunological phenomena. It is characterized by the Presence of circulating organ specific antibodies and lymphocytic infiltration of the affected gland.Case report: A 38-year-old female known to have autoimmune polyglandular ...

ea0070aep557 | General Endocrinology | ECE2020

Role of endocrine specialist nurse in early inpatient discharge

Hawkins Anna , Enriquez Nancy , Casey Edel , Jones Stuart , Nkonge Frederick , Marouf Eltayeb , Nikookam Khash

Adult endocrine specialist nursing (ESN) is a highly specialised role and in recent years nurses have expanded their roles according to local need (Kieffer.V, et al. 2015). As an Endocrine team we review our practice, striving to provide the highest standard of research based, patient centred care. This involves ensuring the best use of resources and service provision in an ever more demanding environment. A new initiative lead by the ESN with consultant supervision w...

ea0070aep558 | General Endocrinology | ECE2020

Delay in diagnosis and clinical course of autoimmune polyglandular syndrome

Sparavalo Rada , Borozan Sanja

Autoimmune polyglandular syndromes (APS) are a rare group of autoimmune disorders that affect more than one endocrine gland, although non-endocrine organs can be involved. Concerning the variable evolution of this clinical entity over time, our case aims to emphasise the importance of regular follow-up and screening for polyglandular autoimmunity in selected patients in order to decrease a possibility of future complications consistent with APS. We report the case of a 20-year...

ea0070aep559 | General Endocrinology | ECE2020

Activity of pure, novel and non-steroidal molecules as inhibitors of AK1C enzyme

Cabeza Marisa , Piermattey Johan Jhoan H. , Gaitán-Ibarra Ricardo , Soriano Juan , Heuzr Yvonne

Prostate and seminal vesicles are male accessory sex glands secreting fluids that, together with sperm, form the semen. Clear evidence indicating these organs depend on androgens was found the men suffering hypogonadism because, in them, the function of these glands decreases markedly. Because prostate and seminal vesicles are androgen-dependent organs, they have been used as a model to test antiandrogenic drugs in different animal species.The objective ...