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Endocrine Abstracts (2020) 70 AEP946 | DOI: 10.1530/endoabs.70.AEP946

ECE2020 Audio ePoster Presentations Thyroid (144 abstracts)

Papillary thyroid cancer with biochemical incomplete response: Clinico-pathological characteristics and disease outcome

Miriam Steinschneider 1 , Mustafa Asly 1 , Efrat Markus 1 , Shlomit Koren 1 , Inna Tkacheva 1 , Carlos Benbassat 2 , Limor Muallem-Kalmovich 1 & Dania Hirsch 3

1Assaf Harofeh Medical Center, Zerifin, Israel; 2Shamir medical center, Tzrifin; 3 Rabin Medical Center, Petah Tikva, Israel

Objective: Althoughmost Papillary Thyroid Cancer (PTC) patients with biochemical incomplete response (BIR) to primary therapy have a good clinical outcome, some will develop disease progression. We aim to study baseline characteristics and long-term outcomes of PTC patients with BIR.

Methods: Of 1049 PTC patients treated at 2 tertiary medical centers, 795 (75.8%) had excellent, 91 (8.7%) biochemical incomplete, 139 (13.2%) structural incomplete and 24 (2.3%) indeterminate response one year after initial treatment. Clinical features, management and disease outcome of 91 BIR patients were evaluated. Mean follow-up was 11.8 ± 6.6 years.

Results: All patients underwent total thyroidectomy, 50.5% neck dissection and 97% RAI (122.4 ± 49 mCi). At diagnosis mean age was 48 ± 17 yr, 67% were females and 77% PTC. Mean tumor size was 25 ± 9 mm, with multifocality in 59.3%, ETE 8th in 24.4%, N1 in 43%, stage 8th in I-II 96.6%, and ATA low-risk 69.7%.No patient had distant metastases. Further treatment included: reoperation 20%, additional I131 52% (cumulative 278 ± 135 mCi). During follow-up 53.8% revert to no evidence of disease, 23.1% remained BIR and 23.1% progressed to structural disease. The switch to structural disease could be predicted by older age, ETE, higher ATA risk and advanced TNM 8th stage. PostOp stTg was not a predictor in BIR patients. At the study-end there were 8 deaths (3 disease-related).

Conclusions: Our data suggest that BIR patients have a generally favorable outcome, however up to 23% may progress to structural disease. In this preliminary study we found some variables to be considered as possible predictor factors

Volume 70

22nd European Congress of Endocrinology

05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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