Searchable abstracts of presentations at key conferences in endocrinology
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22nd European Congress of Endocrinology

05 Sep 2020 - 09 Sep 2020

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Europe's leading endocrinology congress showcasing the very best in the study and treatment of endocrine disorders.

ea0070aep857 | Thyroid | ECE2020

Association with 3-iodothyronamine improves the effect of levothyroxine on neurocognitive symptoms in a mouse model of adult-onset hypothyroidism

Rutigliano Grazia , Frascarelli Sabina , Borsò Marco , Bandini Lavinia , Zucchi Riccardo

Adult-onset hypothyroidism is related to anxiety, depression, and impaired neurocognition. Guidelines from all professional societies recommend levothyroxine (LT4) monotherapy as the treatment of choice. However, ~15% hypothyroid patients do not achieve a satisfactory functional level despite TSH within the reference range. The beneficial effects of combining LT4 and liothyronine (LT3) to improve neuropsychiatric functions remains unclear. Recently, 3-iodothyronamine (T1A...

ea0070aep858 | Thyroid | ECE2020

3-iodothyronamine ameliorates ischemia-induced synaptic dysfunction in mouse entorhinal cortex

Tozzi Francesca , Rutigliano Grazia , Borsò Marco , Zucchi Riccardo , Origlia Nicola

Abnormalities in thyroid hormone (TH) availability and/or metabolism have been hypothesized to contribute to Alzheimer’s disease (AD) and to be a risk factor for stroke. Recently, 3-iodothyronamine (T1AM), an endogenous amine putatively derived from TH metabolism, gained interest for its ability to modulate the nervous and the vascular systems. In the present work, we studied the effect of T1AM on ischemia-induced synaptic dysfunction in the entorhinal cortex (EC), a bra...

ea0070aep859 | Thyroid | ECE2020

Importance of maternal thyroid hormone for programming the cardiovascular system in the male offspring

Pedaran Mehdi , Oelkrug Rebecca , Mittag Jens

Thyroid hormone (TH) plays an important role for brain development. As the fetal thyroid gland only starts providing hormone at the end of pregnancy, the developing brain crucially depends on maternal thyroid hormone in early developmental periods. In previous studies, we have observed that in particular the central control of cardiovascular functions critically depends on maternal thyroid hormone for proper development; however, the precise window when the hormone is benefici...

ea0070aep860 | Thyroid | ECE2020

The natural history of benign thyroid nodules: 10 years follow-up

Ramundo Valeria , Grani Giorgio , Bruno Rocco , Costante Giuseppe , Meringolo Domenico , Puxeddu Efisio , Torlontano Massimo , Tumino Salvatore , Lucisano Giuseppe , Nicolucci Antonio , Filetti Sebastiano , Durante Cosimo

Background and Aim: The incidental detection of asymptomatic thyroid nodules (TNs) has increased over time. Over 90% of newly diagnosed TNs are either cytologically or sonographically benign. This study aimed to determine the frequency and magnitude of changes in TNs size over time.Methods: We performed a prospective, multicenter, observational study involving consecutive euthyroid patients with 1–4 asymptomatic, sonographically or cytological...

ea0070aep861 | Thyroid | ECE2020

How will my life with Graves’ disease be? Two years of serial, longitudinal follow-up of thyroid-related quality of life in patients with Graves’ disease

Grove-Laugesen Diana , Karkov Cramon Per , Ebbehoj Eva , Würgler Hansen Klavs , Rejnmark Lars , Watt Torquil

Objectives: Quality of life (QoL) is severely affected in Graves’ disease (GD) but long-term longitudinal assessment of QoL is lacking. Furthermore, whether QoL is comparable to controls after treatment of GD is unclear. For the first time, we present serial, longitudinal data on thyroid-related QoL during 24 months of follow-up in a cohort of newly diagnosed GD patients. In addition, we compare QoL in GD and controls.Methods: All patients were tre...

ea0070aep862 | Thyroid | ECE2020

Influence of care pathway on thyroid nodule surgery relevance

Castellnou Solene , Jean-Christophe Lifante , Polazzi Stephanie , Pascal Lea , Borson-Chazot Francoise , Duclos Antoine

Objective: Guidelines recommend using fine needle aspiration cytology (FNAC) to guide thyroid nodule surgical indication, however to what extent these guidelines are followed remains unclear. This study aimed to analyze the quality of the preoperative care pathway and the influence of the care pathway on surgical indications relevance.Design: Nationwide historical cohort study based on data from a sample (1/97th) of French health insurance beneficiaries....

ea0070aep863 | Thyroid | ECE2020

Retrospective incidence of NIFTP. A large multicentre Iberic study of over 3000 neoplasms

Paja Miguel , Rosa Bella M. , Iglesias Carmela , Zafón Carles , Cameselle Jose M.l , Carnero Gemma , Póvoa Antónia , Ugalde Aitziber , Anda Emma , Fernández-Seara Pilar , Sánchez-Gómez Nancy M. , Quiceno Hernán , García-Pascual Lluis , González Clarisa , Blanco Concepción , Gómez de la Riva Inés , Capel Ismael , Mancha Isabel , Gallego Helena , Maravall Javier , Roselló Esther , Alcázar Victoria , Chao Montserrat , Lázaro Antonia , Lopez-Agulló Susana , Echeverría Saioa , Joaquín Paricio J. , Sanz Javier , Messeguer Pascual , Castaño Ángel

The newly created NIFTP category (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) has had a notorious impact in the management of thyroid neoplasms. Its incidence appears to be higher in western countries than Asiatic, but there are few studies including more than one institution.Objectives: To evaluate retrospectively the incidence of NITFP in a multicentre study in two adjacent countries as well as to compare th...

ea0070aep864 | Thyroid | ECE2020

Multiple endocrine neoplasia Type 1 (Men1) – genetic variants of Men1 gene in the czech population

Lukasova Petra , kuklik Miloslav , Vankova Marketa , Vondrkova Nela , Vejrazkova Daniela , Moravcova Jitka , Vcelak Josef , Bendlova Bela

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary tumor syndrome. Common manifestations include more than 20 tumors of the parathyroid, pituitary and pancreatic glands and others non-endocrine tumors. The majority of patients carry a germline mutation in a tumor-suppressor gene MEN1, that encodes nuclear protein menin, ubiquitously expressed. So fare, more than 600 germline or somatic mutations have been reported over the...

ea0070aep865 | Thyroid | ECE2020

Targeting RAC1 signaling to potentiate the positive effect of MAPK pathway inhibition on radioiodine uptake

Faria Márcia , Domingues Rita , João Bugalho Maria , Matos Paulo , Silva Ana Luísaer

Introduction: The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid follicular cells, enabling the use of radioactive iodine (RAI) for treatment of metastatic disease. Still, a significant proportion of patients with advanced forms of thyroid cancer (TC) became refractory to RAI therapy. Defective NIS expression is the main reason for impaired iodide uptake in TC and NIS downregulation has been associated with several pathways linked to m...

ea0070aep866 | Thyroid | ECE2020

Radioactive Iodine-Refractory (RAI) Differentiated Thyroid Cancer (rDTC): Analysis of the Canadian Patient Support Program (PSP) for the Prescription and Treatment Patterns of Lenvatinib (LEN)

Boucher Andree , Hortensia Mircescu , Geneviève Rondeau , Rebecca Leboeuf , Bernard Lemieux , Maryse Brassard , Marie-Hélène Massicotte , monika Krzyzanowska , Dean Ruether , Nathaniel Bouganim , Nathan Lamond , Shereen Ezzat , Eric Winquist , Scott Laurie , Neil Chua , Paul Klimo , Howard Lim , Ralph Wong , Ramji Zahra , Alexander Flint , Hauck Wendy , Sebastien Hotte

Differentiated thyroid carcinoma (DTC) is viewed as an indolent disease but 5–15% of patients (pts) become refractory to RAI treatment. This is associated with poor prognosis, a 3–6 years life expectancy and accounts for approximately 200 deaths per year in Canada. There is no universal definition of rDCT and management evolves over time, with either monitoring or systemic therapy including LEN. In the Select Study on LEN in DTC, LEN provided a 19.4 month (mo) medi...

ea0070aep867 | Thyroid | ECE2020

Loss of heterozygosity (LOH) at 12q24.11 as a potential marker of follicular thyroid lesions malignancy

Borowczyk Martyna , Szczepanek-Parulska Ewelina , Budny Bartłomiej , Dębicki Szymon , Verburg Frederik , Filipowicz Dorota , Wrotkowska Elżbieta , Gil Lidia , Janicka-Jedyńska Małgorzata , Oszywa Michalina , Ziemnicka Katarzyna , Ruchala Marek

Introduction: Pre- and postsurgical differentiation between follicular thyroid adenoma (FTA) and follicular thyroid cancer (FTC) represents a significant diagnostic challenge. Typical markers of malignancy may appear as specific genetic alterations. Next-generation sequencing (NGS) studies bring information about single point mutations, however better insight into follicular thyroid lesions genetic landscape, encompassing bigger rearrangements, is needed.<p class="abstext"...

ea0070aep868 | Thyroid | ECE2020

Changes in volume of the thyroid nodule with a previous benign cytological study according to the ultrasound patterns proposed by ATA 2015

javier Pineda José , Munarriz Alcuaz Patricia , Manuel Zubiría Juan , Toni García Marta , Ernaga Ander , Ollero Garcia-Aulló Maria Dolores , de Carlos Joaquin , García Torres Javier , Anda Apiñariz Emma

Objective: To understand the factors associated with changes in thyroid nodule volume with previous benign citology.Material and Methods: This is a prospective single-center observational study. We included patients with a benign citology from March/2016 to May/2018 and ultrasound follow-up after 12–24 months. Initially we determined the nodule size (volume in ml), and its risk of malignancy was classified according to ATA 2015 criteria. Volume cha...

ea0070aep869 | Thyroid | ECE2020

Tocilizumab for corticoid-resistant Graves’ orbitopathy: A case report

Cayón-Blanco Manuel , García-Figueras-Mateos Carolina , Carlos Anglada-Pintado Juan

Introduction: Graves’ ophthalmopathy (GO) is an autoimmune disorder that constitutes a major clinical and therapeutic challenge. Current treatment options for moderate-to-severe GO include immunotherapy, orbital radiotherapy and decompression surgery. Limited drugs of proven efficacy are available for the treatment of people with GO. Given the role in the pathogenesis of GO of interleukin (IL)-6 expression in adipocytes, fibroblasts and macrophages, the proposed theory i...

ea0070aep870 | Thyroid | ECE2020

Dietary pattern and oxidative stress markers in hashimoto’s thyroiditis

Ruggeri Rosaria , Giovinazzo Salvo , Giuffrida Giuseppe , Teresa Vicchio Maria , Teresa Cristani Maria , Alibrandi Angela , Campenni Alfredo , Trimarchi University of Messina Francesco

Objective: Oxidative stress has been implicated in the pathogenesis of several immune-mediated disorders, including autoimmune thyroid disease. Aim of our study was to investigate the relationship between dietary habit and redox homeostasis, in relationship with thyroid autoimmunity.Materials and methods: We enrolled 200 healthy subjects (173 F, mean age 35 ± 12). None of them was under any pharmacological treatment. Exclusion criteria: any infectio...

ea0070aep871 | Thyroid | ECE2020

Catch it if you know – A rare case of impaired TSH measurement

Hoskin Katja , Capraro Joel , Neyer Peter J , Rusch Sebastian

Introduction: Thyreotropin (TSH) is a glycoprotein containing an alpha-subunit similar to other glycoproteins (LH, FSH, ACTH, HCG) and a unique beta-subunit which reacts with the alpha-subunit in binding to the TSH-receptor. Low TSH levels are usually evidence of primary hyperthyreoidism as in Graves diseases/ toxic goiter or thyroiditis, or a result of secondary hypothyroidism in case of diseases of the pituitary gland. This case shows a rare variant causing apparently low TS...

ea0070aep872 | Thyroid | ECE2020

In vitro analysis of the effects of Thyroid Hormones on the electrophysiological activity of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

Ulivieri* Alessandra , Lavra* Luca , Magi Fiorenza , Morgante Alessandra , Salehi Leila B. , Sciacchitano Salvatore

Thyroid hormones (TH)s have as a major target the heart, where they regulate many different functions, including the modulation of the heart rate and myocyte contractility. Their effects on ventricular repolarization are controversial and QT prolongation was reported both in patients with hypothyroidism and hyperthyroidism, in their overt or subclinical forms. We analyzed the effects of 3.3',5.5'-tetraiodo-L-Thyronine (T4), 3.3',5-triiodo-L-Thyronine (T3) and of 3.3',5'-triiod...

ea0070aep873 | Thyroid | ECE2020

Treating thyroid nodules by radiofrequency: The delivered energy should be correlated with the volume reduction rate

Deandrea Maurilio , Trimboli Pierpaolo

Context: Radiofrequency ablation (RFA) was proven as effective in reducing thyroid nodules’ volume. However, whether technical procedure aspects could influence the volume reduction rate (VRR) has not been clarified.Objective: To analyze the correlation of RFA power, duration and energy with VRR.Design: Prospective study from June 2018 to December 2019.Setting: Two primary-care centers using the same RF...

ea0070aep874 | Thyroid | ECE2020

Changes in morphology and gene expressions of neonatally X-irradiated thyroid gland in rats

Fujimoto Nariaki , Matsuu-Matsuyama Mutsumi , Nakashima Masahiro

Purpose: Exposure to ionizing radiation in childhood has been recognized as a risk factor for the development of thyroid cancer and possibly for other thyroid disorders. However, the effects of neonatal radiation exposure on thyroid functions have never been explored experimentally despite its potential importance. We have demonstrated that neonatal rat thyroid was sensitive to ionizing radiation, developing specific morphological changes characterized by smaller thyroid folli...

ea0070aep875 | Thyroid | ECE2020

Treatment of hyperthyroidism reduces the systemic oxidative stress load, as measured by biomarkers of RNA and DNA damages

Larsen Camilla , Ryom Riis Kamilla , Hillert Winter Kristian , List Larsen Emil , Ellervik Christina , Hegedüs Laszlo , Brix Thomas , Enghusen Poulsen Henrik , Joop Bonnema Steen

Background: Increased oxidative stress has been linked to both hypo- and hyperthyroidism. Whole-body oxidative stress can be estimated by the oxidized guanine nucleosides, 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These biomarkers have been associated with increased morbidity and mortality in several diseases but are not well explored in humans with thyroid disorders.<p class="abst...

ea0070aep876 | Thyroid | ECE2020

Diffuse Large B-cell Lymphoma of thyroid gland in an Adolescent girl with Hashimoto’s thyroiditis

Xatzipsalti Mara , Bourousis Evangelos , Nikita Maria , Gkeli Myrsini , Magkou Evgenia , Papachristidou Smaragda , Rontogianni Dimitra , Delis Dimitris , Baka Margarita , Vazeou Andriani

Background: Cancer of thyroid gland is rare in childhood, representing 1% of all pediatric malignancies. Primary thyroid lymphoma (PTL) is even rarer accounting for 5% of thyroid malignancies and 2% of extranodal lymphomas. The disease affects mainly adults in thesixth orseventh decade of life, with a female predominance. Most thyroid lymphomas are non-Hodgkin’s lymphomas (nHL) of B-cell origin. The most common type is Diffuse Large B- cell Lymphoma (DLBCL). Patients wit...

ea0070aep877 | Thyroid | ECE2020

Breast cancer metastasis to the thyroid gland – A case report

Michou Aikaterini , Kakoulidis Ioannis , Ilias Ioannis , Venaki Evangelia , Koukkou Eftychia

Introduction: Metastases to the thyroid are rare (1.4–3% of malignant solid tumors). When present, metastatic cancers mimic the ultrasound image of the thyroid parenchyma, hindering diagnosis. Breast cancer rarely metastasizes to the thyroid.Case: A 61-year-old woman was referred for goiterin the context of post-surgery evaluation for breast cancer. Thyrotropin (1.14 mIU/l), calcitonin (0.5 pg/ml) and parathyroidhormone (54 pg/ml) levels were norma...

ea0070aep878 | Thyroid | ECE2020

Clinical case of autoimmune encephalopathy (Hashimoto) with a psycho-organic syndrome on the background of autoimmune thyroiditis

Rusalenko Mariya , Marchenko Svetlana , Pispanen Evgeniy , Tsukanova Svetlana , Hadanovic Sergey

Introduction: Hashimoto’s Encephalopathy (HE) is an autoimmune inflammatory disease of the brain associated with the production of antithyroid antibodies.Objective: A clinical case of treatment of severe autoimmune encephalopathy in combination with autoimmune thyroiditis and thyrotoxicosis is presented.Results: A 59-year-old woman was transferred to the intensive care unit diagnosed with thyrotoxic crisis. Objectively: serio...

ea0070aep879 | Thyroid | ECE2020

Influence of Sodium Iodide symporter expression level on recurrence rate in differentiated thyroid cancer

Farafonova Uliana , Boriskova Marina , Pankova Polina , Koloskova Ludmila

The ability of thyroid cell to accumulate iodine is due to presence of sodium iodide symporter (NIS). Differentiated thyroid cancer (DTC) maintain ability to express NIS and thus it makes possible to perform RAI treatment. In case of DTC cells loss the ability of NIS protein production and cell membrane embedding that leads to RAI treatment fail.The aim of our study was to find a relationship between the level of preoperatively defined NIS and recurrence...

ea0070aep880 | Thyroid | ECE2020

Clinical practice survey on BRAF V600E role in the therapeutic decision in indeterminate thyroid cytology

Brigante Giulia , Craparo Andrea , Pignatti Elisa , Marino Marco , Casarini Livio , Sperduti Samantha , Boselli Gisella , Margiotta Gianluca , Rochira Vincenzo , Simoni Manuela

Introduction: The use of multigene panels in thyroid nodule diagnosis is still limited, due to high costs and need for ad hoc sampling. Since BRAF-V600E is the commonest genetic alteration in differentiated thyroid cancer, this is the mostly tested genetic parameter in clinical practice.Aim: To evaluate the use of BRAF mutation analysis in wash-out liquid from fine needle aspiration (FNA) in clinical practice, characterizing th...

ea0070aep881 | Thyroid | ECE2020

The diagnostic value of basal and calcium-stimulated procalcitonin for the diagnosis of medullary thyroid cancer: Preliminary results from a multicentric experience

Censi Simona , Di Stefano Marta , Repaci Andrea , Manso Jacopo , Pagotto Uberto , Bertazza Loris , Barollo Susi , Plebani Mario , Colombo Carla , Fugazzola Laura , Mian Caterina

Background: Calcitonin (CT) is the most sensitive marker for MTC diagnosis. By the way, many pre-analytical, analytical and post-analytical pitfalls worsen its accuracy. Procalcitonin (proCT), a CT precursor, has been suggested as a valuable complementary test in MTC diagnosis, given its stability and the reproducibility between different assay kits.Material and Methods: basal CT (bCT) and proCT (bproCT) and stimulated CT (bCT) and proCT (sproCT) (2&#821...

ea0070aep882 | Thyroid | ECE2020

In vitro modeling of thyroid cancer cells and fibroblasts interplay

Stellaria Grassi Elisa , Ghiandai Viola , Pogliaghi Gabriele , Fugazzola Laura , Persani Luca

Thyroid cancer (TC) is the most common endocrine tumor and its incidence has increased faster than in any other malignancy. Although TCs are usually well differentiated, disease recurrence or persistence is high, because of local and distant metastasis and therapeutic resistance. Among the different genetic alterations, BRAFV600E is the most frequent one. Several studies tried to establish a correlation between BRAFV600E and patients outcome, with controversial results. Nevert...

ea0070aep883 | Thyroid | ECE2020

Description of thyroid alterations in oncological patients treated with immune checkpoint inhibitors: Experience of a tertiary hospital

García-Blasco Lourdes , Jimenez-Martinez Cortes , Riesco-Montes Blanca , Soler Ana

Introduction: There has been an increase in the use of new drugs called immune checkpoint inhibitors (ICPI) used in advanced tumors. Clinical trials have also reported an increased risk of developing immune-related adverse events (IRAEs). Endocrine IRAEs may be particularly relevant.Material and Methods: This is a retrospective study. Patients treated with ICPI were obtained from Medical Oncology departament of the General University Hospital of Albacete...

ea0070aep884 | Thyroid | ECE2020

Multiple thyroid gland ectopia in a patient with hypopituitarism

Nonchev Boyan , Argatska Antoaneta

Introduction: Ectopic thyroid tissue is a rare developmental abnormality resulting from aberrant embryogenesis of the thyroid gland during its passage from the floor of the primitive foregut to its final pre-tracheal position. It may be the only functional thyroid tissue or may co-exist with normally located thyroid. Most of the cases are asymptomatic but symptoms related to location, size or function may occur. Possible malignancy potential has also been discussed.<p clas...

ea0070aep885 | Thyroid | ECE2020

Clinical severity score (CSS) and graves’ recurrent events after therapy (GREAT) score could predict radioiodine efficacy for treatment of Graves’ disease relapse

Repaci Andrea , Beleffi Michelle , Salituro Nicola , Colapinto Alessandra , Vicennati Valentina , Pelusi Carla , Altieri Paola , Gambineri Alessandra , Di Dalmazi Guido , Pagotto Uberto

Background: Antithyroid drugs (ATDs) are the first line treatment for Graves’ disease in Europe and Asia. However, their long term-efficacy is doubtful, with a high disease relapse rate after discontinuation. Radioiodine and surgery can be used as a second line therapy as definitive approaches after ATDs failure. In recent years, the GREAT and the CSS scores have been suggested to assess the risk of relapse at the time of disease onset, but no data are available about th...

ea0070aep886 | Thyroid | ECE2020

Ectopic thyroid tissue presented as left adrenal mass – a case report

Samardzic Vladimir , Gluvic Zoran , Lackovic Milena , Tica Jelena , Popovic-Radinovic Vesna , Vujovic Marina , Obradovic Milan , Isenovic Esma R.

Introduction: Ectopic thyroid tissue is a rare developmental abnormality with the prevalence of 1 per 100.000–300.000 persons in the general population. It is most commonly detected in younger women and presented as lingual thyroid. Here we report a rare case of ectopic thyroid tissue in the left adrenal gland.Case report: A 29-year old female without previous medical history was incidentally diagnosed with left adrenal gland mass detected on routi...

ea0070aep887 | Thyroid | ECE2020

Vitamin D supply influences negatively the serum IL-6 and IL-17A levels in Hashimoto’s thyroiditis, while positively the serum antibody levels against thyroid peroxidase and TSH receptor in Graves’ disease

Molnár Ildikó , Nagy Zoltán

Vitamin D plays an important role in the adaptive and innate immunity besides its skeletal effects. Some autoimmune disease is associated with vitamin D deficiency highlighting its crucial involvement in the onset of autoimmune diseases. This study investigated the relationship between the vitamin D supply and the serum IL-6, IL-17A and antibody levels against thyroid peroxidase (TPO) and TSH receptor in autoimmune thyroid diseases. Serum IL-6, IL-17A and antibody levels again...

ea0070aep888 | Thyroid | ECE2020

Cumulative effects of thyroid hormones over 10 years and risk of general and abdominal obesity; tehran thyroid study

Mehran Ladan , Amouzegar Atieh , Abdi Hengameh , Gharibzadeh Safoora , Mansournia Mohammadali , tohidi Maryam , Azizi Fereidoun

Background: Recently many cross-sectional and a few longitudinal studies reported that thyroid hormones even within normal ranges are associated with measures of adiposity. We aim to assess if changes in TSH and Free T4 (FT4) over 10 years of follow-up would be associated with changes in BMI and waist circumference or risk of general and abdominal obesity.Methods: 4179 participants of Tehran Thyroid Study(TTS) who had attended at baseline(1999–2001...

ea0070aep889 | Thyroid | ECE2020

Iodine deficiency and mortality in spanish adults. [email protected] study

Valdes Sergio , Colomo Natalia , Maldonado-Araque Cristina , García-Fuentes Eduardo , Calle-Pascual Alfonso , Castaño Luis , Delgado Elias , Franch-Nadal Josep , Soriguer Federico , Rojo-Martinez Gemma

Objective: To study the association between the state of iodine nutrition, and the risk of total and cause mortality in a representative sample of the Spanish adult population.Design: Longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the national study [email protected] (2008–2010). We used ...

ea0070aep890 | Thyroid | ECE2020

New predictors of response to treatment with intravenous methylprednisolone in thyroid-associated orbitopathy

Roman Gimeno Sergio , Jorge Ortez Toro Jose , Miguel Peteiro Miranda Carlos , Sanz Martín Borja , Urdaniz Rosana , Agudo Ana , Borau Laura , Campos Fernández Julia , Aguillo Gutierrez Esperanza

Introduction: Thyroid-associated ophthalmopathy is the most frequent extrathyroidal manifestation of Graves’ disease. Its treatment is based on the administration of intravenous corticosteroids, and the clinical activity score (CAS), TSH-binding inhibitor immunoglobulin (TBII) and TSH-receptor antibodies (TRAb) have been classically used to measure the response to treatment. However, in recent studies [1] it has been observed that other analytical parameters such as chol...

ea0070aep891 | Thyroid | ECE2020

Differentiation of follicular thyroid cancer from follicular thyroid adenoma with sonographic features – results of a meta-analysis

Borowczyk Martyna , Woliński Kosma , Więckowska Barbara , Jodłowska-Siewert Elżbieta , Szczepanek-Parulska Ewelina , Ruchala Marek

Introduction: According to the results of several studies and meta-analyses, certain ultrasound features are associated with increased risk of thyroid malignancy. However, most of those research papers included mainly papillary thyroid cancers (PTCs); these results cannot be simply extrapolated for the differentiation of follicular thyroid adenomas and cancers (FTAs and FTCs). The aim of the present study was to perform a meta-analysis of so far conducted research and identify...

ea0070aep892 | Thyroid | ECE2020

Anaplastic thyroid cancer arising froma patient with congenital thyroid dyshormonogenesis; A case report with a novel thyroglobulin gene mutation

Yoon Jeehee , Ram Hong A , Kim HeeKyung , Kang Ho-Cheol

Background: Concomitant thyroid cancer in patients with congenital thyroid dyshormonogesis (TD) is extremely rare and only few cases of differentiated thyroid cancer in patients with TD were reported in literature. We present the first case of anaplastic thyroid cancer (ATC) in woman with TD.Case: A 46-year-old female patient was referred to our hospital for thyroid surgery due to rapid tumor growing and compressive symptoms. The fine needle aspiration r...

ea0070aep893 | Thyroid | ECE2020

Thyroglobulin measurement in fine-needle aspirates of lymph nodes in patients with differentiated thyroid cancer

Zuraeva Zamira , Nikankina Larisa , Kolesnikova Galina , Abdulhabirova Fatima , Rumiantsev Pavel , Vanushko Vladimir , Malysheva Natalia

Backgraund: The high incidence of cervical lymph nodes (LNs) metastasis in differentiated thyroid carcinoma (DTC) and lack of effective diagnostic tools determines the need for elaboration more specific tests.Aims: The aim of our study was to evaluate the accuracy and cut-off point of the thyroglobulin (Tg) in the washout fluid of fine-needle aspiration biopsy (FNA-Tg) in the diagnosis of DTC LNs metastasis.Materials and methods: A...

ea0070aep894 | Thyroid | ECE2020

Association between multifocality and aggressive histopathological findings in papillary thyroid cancer

Monzón Mendiolea Andoni , Oleaga Alday Amelia , Leyre Martínez Martínez Adela , Merlo Pascual Ignacio , Etxeberria Martin Eider , Paja Fano Miguel

Introduction: Papillary thyroid cancer (PTC) is usually tied to an excellent prognosis, with a 10-year disease specific survival rate of 98%. Nevertheless, some clinicopathological features are associated with a worse outcome. Therefore, a precise risk assessment is crucial for the clinicians deciding the most appropriate treatment for each tumour. Multifocal tumours (MFPTC) appear to have be a worse prognosis than unifocal tumours (UFPTC) in some series, but this aspect is di...

ea0070aep895 | Thyroid | ECE2020

Cervical lymph node metastasis of a thyroid papillary carcinoma resected with detection by technetium99-nanocolloid: About an original case

Bouchenna Amira , Fatma Berkoune , Brahim Ghennam , Abdelghani Tibouk , Adel Guidoum , El Mahdi Heffaf , Kablia Samia Ould

Introduction: Cervical lymph node metastases from differentiated thyroid carcinomas occur mainly in the central compartment with an incidence between 20 and 90% (average 60%). The American Thyroid Association considers that the central compartment goes to the unnamed artery thus systematically including level VII to level VI. We report the case of a patient with resected level VII lymph thanks to identification by technetium99-nanocolloid.Observation: Pa...

ea0070aep896 | Thyroid | ECE2020

PTEN-hamartoma tumour syndrome and thyroid nodular disease: 3 case reports

Fadiga Lúcia , Catarino Diana , Saraiva Joana , Dinis Isabel , Cardoso Rita , Serra Caetano Joana , Paiva Isabel , Mirante Alice

Introduction: Germline mutations in tumour suppressor gene PTEN cause heterogeneous phenotypes, that comprise the spectrum of PTEN-hamartoma tumour syndrome (PHTS). Manifestations include macrocephaly, developmental delay, cutaneous lesions, intestinal polyposis and increased risk of neoplasms. Thyroid nodules are identified in about 75% of patients and follicular cell-derived cancer affects 35% of cases, some of which diagnosed as early as 7 years old.C...

ea0070aep897 | Thyroid | ECE2020

Discordant thyroid function test in a patient with X-linked adrenoleukodystrophy

Pant Vivek , Baral Suman

Introduction: Biotin-streptavidin detection method is used in a majority of commercial immunoassay. Biotinylated antibodies (capture antibodies) bind strongly to streptavidin that anchors those antibodies to the solid phase of the assay. Thus, high biotin concentration in the serum interferes with this bond and alters the expected results. Clinical history of patient and additional laboratory test is important for troubleshooting of discordant thyroid function test result....

ea0070aep898 | Thyroid | ECE2020

Age and sex-specific TSH upper-limit reference intervals in the general French population: There is a need to adjust our actual practices

Raverot Véronique , Maxime Bonjour , Juliette Abeillon , Pauline Perrin , Florence Roucher , Hélène Lasolle , Fabien Subtil , Borson-Chazot Francoise

Background: The increasing age of the general population represents a new challenge for endocrinologists and caregivers since it is well know that the occurrence of thyroid dysfunction increases with age. It is still controversial whether or not reference values of thyrotropin (TSH) adapted to age and sex need to be used. Herein, we aimed to determine reference intervals, in males and females, suitable for thyroid disease exploration and follow-up during adult life in a tertia...

ea0070aep899 | Thyroid | ECE2020

Thyroid hormone regulation of brain metabolism: Study in an animal model of the co-occurrence of depression and hypothyroidism

Glombik Katarzyna , Detka Jan , Budziszewska Boguslawa

Objective: Thyroid hormones are required not only for central nervous system development in the early stages of life but also play a key role in the maintenance of adult brain function. It is known that in adults, thyroid diseases can lead to various clinical manifestations i.e affective disorders, depression, memory impairment. The effects of hypothyroidism on brain functions seem particularly pronounced in depression, but until now, the mechanism underlying this relationship...

ea0070aep900 | Thyroid | ECE2020

Severe toxic reaction on thiamazole in a patient with hyperthyreoidism

Jambrović Martina , Maric Andreja , Mikolaj Kiric Maja

Female patient (56 y) with hyperthyroidism (start TSH 0.01 mIU/l; fT3 15.8 pmol/l; fT4 39.4 pmol/l) one month after initiation of thiamazole therapy (10 mg 3 × 1/1 week, then 2 × 1) came to the emergency room with symptoms of sweating, palpitations, nervousness, itching, fever (37.6 C), icterus. In medical history: oesophageal achalasia surgery 5 years ago, non-smoker. Therapy: thiamazole, bisoprolol, alprazolam. Initially in laboratory findi...

ea0070aep901 | Thyroid | ECE2020

How various doses of iodine effect on thyroid gland in pregnant and lactating women, on the example of regional studies in russian federation?

Rybakova Anastasia , Platonova Nadezhda , Troshina Ekaterina , Abdulhabirova Fatima

Relevance: Question of standards of iodine intake in pregnant and lactating women remains relevant.Aim of study: to determine status and function of thyroid gland in pregnant and lactating women with and without antibodies to thyroid gland, on the background of taking different doses of iodine in 3 different regions of Russia with different iodine status.Materials and methods: This study included 414 women in the different trimeste...

ea0070aep902 | Thyroid | ECE2020

Association between lipid and thyroid function parametersin premenopausal euthyroid healthy women and women on levothyroxine replacement therapy

Argatska Antoaneta , Nonchev Boyan

Introduction: The relationship between thyroid function tests and lipid parameters is still under hot discussion. According to current recommendations thyroid stimulating hormone (TSH) levels should preferably be below 2.5 mIU/l in healthy women of childbearing age as well as in women on levothyroxine treatment.Aim: To compare lipid levels and atherogenic indices in premenopausal euthyroid healthy women and women with autoimmune thyroiditis (AIT) on levo...

ea0070aep903 | Thyroid | ECE2020

The effect of ramadan fasting on thyroid function tests: A study of patients on thyroxine replacement therapy

Alkaf Budour , Ali Tomader , Bakir Ali , Lessan Nader

Background: Ramadan fasting entails abstinence of food and drink from dawn to sunset for 30 days. Medication timing also changes; for patients with hypothyroidism this can be a challenge as levothyroxine (LT4) is normally taken on an empty stomach and at least half an hour before breakfast. Complying with this advice during Ramadan is impractical for religious and social reasons. Adverse changes in thyroid function in patients with hypothyroidism have been observed. Whether an...

ea0070aep904 | Thyroid | ECE2020

Non-thyroidal illness syndrome in patients admitted for acute disease and its relationship to survival

Siarkos Evangelos , Athanassiou Lambros , Spyropoulou Olga-Maria , Mascha Olga , Samaras Charilaos , Athanassiou Panagiotis , Kostoglou-Athanassiou Ifigenia

Introduction: Non-thyroidal illness syndrome or low T3 syndrome is an alteration of thyroid hormone levels which occurs as a reaction to acute disease. It is characterized by low TSH levels and low T3 and T4 levels. It is transient. The severity of its expression may be related to the severity of the acute disease. It affects patients hospitalized for acute disease in the department of medicine or surgery and in the acute care unit.<p class...

ea0070aep905 | Thyroid | ECE2020

Spurious thyroid function test results due to interference: Consider concealed biotin in health supplements

Kyung Kim Hee , Hee Yoon Jee , Ram Hong A , Kang Ho-Cheol

Biotin is used in many hormone immunoassays as an immobilizing system as streptavidin binds biotin with high affinity. Recently, cases with spurious results from biotin interference have been increasing due to widespread use of vitamin supplements containing biotin. We report two cases of erroneously high total T3 levels caused by biotin interference.Case 1: A 88-year-old female who had total thyroidectomy for papillary thyroid cancer 10 years ago and ha...

ea0070aep906 | Thyroid | ECE2020

The effect of selenium supplementation and gluten-free diet in patients with subclinical hypothyroidism affected by autoimmune thyroiditis

Velija Asimi Zelija , Hadzovic-Dzuvo Almira , Al Tawil Djinan

Introduction: Ongoing scientific research indicates that there is a dangerous link between eating foods that contain gluten and Hashimoto’s thyroiditis (HT). Gluten can be an irritant to HT by creating inflammation in the thyroid gland. Selenium, an important oligoelement, is a component of the antioxidant system. Over the last decade, it has been ever more frequently discussed in the context of thyroid disorders. The purpose of this study was to highlight the positive r...

ea0070aep907 | Thyroid | ECE2020

Iodine sufficiency among school age children of Minsk region (Belarus) in 2018

Mokhort Tatsiana , Kolomiets Natalia , Petrenko Sergey , Mokhort Alena , Fedorenko Ekaterina

Background: The problem of iodine deficiency in Belarus remains topical, due to the historical understanding of iodine deficiency in the environment. As a result, the Republic of Belarus has developed and since 2000 implemented a strategy for iodine deficiency elimination, based on the use of iodized salt and food fortification.Aims: To determine iodine status in children living in Minsk region.Materials and methods: The study incl...

ea0070aep908 | Thyroid | ECE2020

The use of different sodium/potassium perchlorate regimes could affect response time in the treatment of amiodarone-induced thyrotoxicosis

Pazos Mario , Cuesta Martín , Pallarés Raquel , Ramos Elvira , Barrio Elvira , Puebla Virginia , De Miguel Paz , Ángel Díaz Jose , Calle Alfonso , Runkle Isabelle

Introduction: In the treatment of amiodarone-induced type I or mixed thyrotoxicosis, sodium or potassium perchlorate is often associated to thionamides, when the latter are insufficient for a prompt control of thyroid hormone secretion. Perchlorate competes with iodine for entrance into the follicular cell, and also induces a discharge of iodine from these cells with each administration. We compare the effect of 3 different regimes of perchlorate with methimazole on control of...

ea0070aep909 | Thyroid | ECE2020

Plasma levels of Th17 associated cytokines in patients with autoimmune thyroid disease

Zake Tatjana , Kalere Ieva , Upmale Sabine , Gersone Gita , Konrade Ilze

Introduction and aim: Cytokines play a crucial role in modulating immune response in both Hashimoto’s thyroiditis (HT) and Graves’ disease (GD). They may contribute to drive the autoimmune response skewing toward the Th17 phenotype and away from Th1 or Th2 phenotypes. Recent studies revealed an essential role of Th17 cells and their cytokines in the development of autoimmune thyroid diseases (AITD). However, participation of Th17 cells in the pathogenesis of GD is ...

ea0070aep910 | Thyroid | ECE2020

The use of single dose of rituximab in combination with radiotherapy, in the treatment of Graves’ Orbitopathy – clinical observations

Gojny Łukasz , Moskwa Agnieszka , Bolanowski Marek , Daroszewski Jacek

The treatment of orbitopathy in the course of Graves’ disease (GO, Graves’ Orbitopathy) still remains a serious therapeutic challenge. Modification of risk factors is considered to be the most important and the most effective method of treatment of benign GO. Treatment with intravenous glucocorticosteroid preparations remains the first-line therapy for moderate- to severe GO but is insufficient in some patients. Radiotherapy has been used in active GO therapy for d...

ea0070aep911 | Thyroid | ECE2020

Insulin resistance, lipid profile and low-grade inflammation in Hashimoto thyroiditis

Afonso Marta , Neves Celestino , Sérgio Neves João , Pereira Miguel , Luís Medina José , Delgado Luís , Carvalho Davide

Background: Hashimoto thyroiditis (HT) is the most common autoimmune disease and patients may present different levels of thyroid dysfunction. The association between hypothyroidism and cardiovascular events is well established. However, it remains unclear how mild thyroid dysfunction, autoimmunity and chronic inflammation in HT contribute to an increased cardiovascular risk in euthyroid patients and in subclinical hypothyrodism. Therefore, this study aims to assess insulin re...

ea0070aep912 | Thyroid | ECE2020

Thyroid arterial embolization for refractory amiodarone-induced thyrotoxicosis in a patient with congenital heart disease

Bouça Bruno , Cláudia Martins Ana , Bogalho Paula , de Sousa Lídia , Bilhim Tiago , Veloso Gomes Filipe , Coimbra Élia , Agapito Ana

Introduction: Amiodarone-induced thyrotoxicosis (AIT) in patients with congenital heart disease (CHD) has an estimated cumulative incidence of 13–21%, and prompt reversal to euthyroidism is crucial in these patients. We present a case of refractory AIT in a patient with CHD who was treated with thyroid arterial embolization (TAE).Clinical case: A 34-year-old male with complex cyanotic CHD (great vessels transposition, interventricular communication...

ea0070aep913 | Thyroid | ECE2020

Effect of increased levothyroxine dose on depressive mood in older adults undergoing thyroid hormone replacement therapy

Hoon Moon Jae , Won Han Ji , Jung Oh Tae , Hee Choi Sung , Lim Soo , Woong Kim Ki , Chul Jang Hak

Background: Depressive mood consequent to hypothyroidism can be reversed with levothyroxine (LT4) replacement therapy. However, it is unclear whether increasing LT4 dose confers additional mood benefits.Methods: This was a single-blind before-and-after study of 26 patients with hypothyroidism who were aged 65 years or older and undergoing LT4 replacement therapy. Geriatric Depression Scale (GDS-K) and Hyperthyroid Symptom Scale (HSS-K) were assessed at b...

ea0070aep914 | Thyroid | ECE2020

Thyroid imaging in the management of anti-PD1/PD-L1 induced thyrotoxicosis

Brancatella Alessandro , Lupi Isabella , Viola Nicola , Sgrò Daniele , Antonangeli Lucia , Montanelli Lucia , Sardella Chiara , Brogioni Sandra , Ricci Debora , Bianchi Francesca , Piaggi Paolo , Santini Ferruccio , Marcocci Claudio , Latrofa Francesco

Context: Thyrotoxicosis is the most common endocrine adverse event due totreatment with anti-PD1 and anti-PD-L1. The most common form is destructive thyrotoxicosis whereas persistent, supposedly autoimmune hyperthyroidism (Graves’ hyperthyroidism) is rare. The possible role of thyroid imaging (neck ultrasound and scintigraphy) in the differential diagnosis has never evaluated.Aim: To evaluate the usefulness of neck ultrasound and 99Tc- s...

ea0070aep915 | Thyroid | ECE2020

Follicular fluid progesterone in thyroid autoantibodies positive women and assisted reproductive technology outcome

Medenica Sanja , Garalejic Eliana , Arsic Biljana , Medjo Biljana , Bojovic Jovic Dragana , Abazovic Dzihan , Vukovic Rade , Vujosevic Snezana , Zarkovic Milos

Objective: Progesterone (P4) is essential for successful embryo implantation and preventing miscarriage. The strong connection between thyroid autoimmunity (TAI) and infertility is highlighted in literature. Follicular fluid (FF) is important for the oocyte maturation. The aim of the study was to assess the influence of FF P4 in TAI positive women on assisted reproductive technology (ART) outcome.Methods: The study included 52 women undergoing ART. Befor...

ea0070aep916 | Thyroid | ECE2020

Subclinical hypothyroidism and non-alcoholic fatty liver disease: A systematic review and meta-analysis

Guzman-Prado Yuli , Samson Ondrej

Introduction: Hypothyroidism has been reported as an important factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) but studies about the relation between subclinical hypothyroidism and NAFLD have shown contradictory findings. The aim of this study was to conduct a systematic review and meta-analysis exploring the association between subclinical hypothyroidism and NAFLD.Methods: MEDLINE, EMBASE, Cochrane Library and sources for grey li...

ea0070aep917 | Thyroid | ECE2020

Total thyroidectomy for amiodarone-induced thyrotoxicosis: Identification of the surgical candidates and preparation to surgery

Cappellani Daniele , Papini Piermarco , Maria Di Certo Agostino , Mantuano Michele , Manetti Luca , Materazzi Gabriele , Bartalena Luigi , Bogazzi Fausto

Background: Amiodarone-induced thyrotoxicosis (AIT) is a challenging disease associated with increased morbidity and mortality. The European Thyroid Association guidelines define the role for total thyroidectomy in the management of AIT. However, these recommendations were based on small series, which often lead to heterogeneous results and, importantly, did not identify patients who may benefit from surgery.Materials and methods: Observational longitudi...

ea0070aep918 | Thyroid | ECE2020

PEG precipitation of TSH in subclinical hypothyroidism. A study of 398 samples in real-world setting

Mammadov Emin , Bercu Cristian , Dinescu Mihaela , Vasile Ileanu Bogdan , Neamtu Corina

Background: Hypothyroidism is defined as an elevated TSH (thyroid-stimulating hormone) and/or decreased free thyroxine (FT4) levels. Levothyroxine is now one of the most widely prescribed medications. However, treatment indications are controversial in subclinical hypothyroidism, defined as high TSH with normal T4 levels. Methods: We performed a cross-sectional study reviewing the blood samples received in our Laboratory for TSH determination during the ...

ea0070aep919 | Thyroid | ECE2020

The effects of naringenin on NRF2 and antioxidant enzymes expressions in the thyroids of the old-aged Wistar rats

Miler Marko , Živanović Jasmina , Ajdžanović Vladimir , Šošić-Jurjević Branka , Marković Zorica , Milošević Verica

Citrus flavanone naringenin (NAR) is a potent antioxidant with ability to change pituitary-thyroid function. NAR increases concentration of thyroid-stimulating hormone (TSH) in serum by increasing Sirtuin1 expression in the pituitary thyrotrophs and improves thyroid hormonogenesis capacity in old-aged rats. Thyroid hormone production is followed by generation of large quantities of reactive oxygen species (ROS) which are essential for iodine organification. A master regulator ...

ea0070aep920 | Thyroid | ECE2020

Retrospective analysis of low risk thyroid cancers. Total thyroidectomy or lobectomy is the optimal approach for follow up?

Hella Zoltán , Vass László , Csapó Zsolt , László Kovács Gábor

Background: Differentiated thyroid cancer (DTC) <1 cm without risk factors require only lobectomy, and there is no need for radioiodine remnant ablation (RRA). The approach for surgery and RRA after surgery is less clearly defined for tumours measuring 1–4 cm.Objectives: We aimed to evaluate the surgical approaches of DTC in stages pT1–2 in a moderate iodine deficient area. We compared our data to the current European Thyroid As...

ea0070aep921 | Thyroid | ECE2020

Early diagnosis of medullary thyroid cancer in case of low serum calcitonin: Role of calcitonin measurement in fine-needle aspiration washout fluid

Greco Carla , Madeo Bruno , Rochira Vincenzo , Cristina De Santis Maria , Brigante Giulia

Background: Screening serum calcitonin (sCT) measurement in patients with thyroid nodules is still debated. Moreover, sCt cutoffs for medullary thyroid carcinoma (MTC) are not univocally defined. Also, sensitivity of cytology by fine needle aspiration biopsy (FNAb) has been demonstrated to detect approximately half of MTCs. Ct measurement in fine-needle aspiration washout fluid (Ct-FNAb) has high sensitivity and specificity and is helpful in case of non-diagnostic cytology&#18...

ea0070aep922 | Thyroid | ECE2020

Impact ofhypothyroidism on early preneoplastic changes at the transcriptomic level in mammalian cells

Hanusek Karolina , Duda Monika , Piekiełko-Witkowska Agnieszka

Introduction: Studies suggest that disturbed thyroid hormones (TH) homeostasis may lead to increased cancer risk. However, the exact role of TH in cancerogenesis is unknown. We have previously identified 15 genes linked with TH signaling in 7 cancer types and 10.967 cancer patients. Here, we investigated the influence of hypothyroidism on the expression of these 15 genes in rat tissues/organs from which the previously identified, TH-related cancer types originate.<p class=...

ea0070aep923 | Thyroid | ECE2020

Adverse effects of tyrosine kinase inhibitors in advanced thyroid carcinoma – a summary of 10-year experience

Krajewska Jolanta , Kukulska Aleksandra , Paliczka-Cieslik Ewa , Gawlik Tomasz , Olczyk Tomasz , Ledwon Aleksandra , Michalik Barbara , Kropinska Aleksadra , Handkiewicz-Junak Daria , Jarzab Barbara

Introduction: To date, only four tyrosine kinase inhibitors (TKIs) have demonstrated beneficial effect on progression free survival in advanced medullary thyroid cancer (MTC; vandetanib and cabozantinib) andradioiodine-refractory differentiated thyroid cancer (RR-DTC; sorafenib and lenvatinib). However, there is still lack of unequivocal proofs of their significant impact on overall survival. Therefore, treatment-related side effects and their potential impact on quality of li...

ea0070aep924 | Thyroid | ECE2020

Octreotide and pasireotide effects on medullary thyroid carcinoma (MTC) cells growth, migration and invasion

Catalano Rosa , Mangili Federica , Giardino Elena , Maria Barbieri Anna , Treppiedi Donatella , Dolci Alessia , Contarino Andrea , Spada Anna , Arosio Maura , Mantovani Giovanna , Peverelli Erika

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor of the parafollicular thyroid C cells. Although somatostatin (SS) receptors (SSTs) are expressed by MTCs, treatment with octreotide, specific for SST2, has shown poor efficacy in reducing MTC proliferation, whereas pasireotide, a multi-receptor SS analogue with preferential binding to SST5, has recently demonstrated antiproliferative effects in persistent postoperative MTCs. In vitro data in human MTC ce...

ea0070aep925 | Thyroid | ECE2020

Basal and stimulated calcitonin: Different experience on liaison and cobas assays

Băetu Mara , Drăghici Alexandru , Pădure Adriana , Caragheorgheopol Andra , Badiu Corin

Introduction: The determination of basal and stimulated calcitonin (CT) is very important for the precocious diagnosis of medullary thyroid carcinoma (MTC) and for its dynamic follow-up. Unfortunately, monitoring is difficult when using assays with different detection systems. Our objective was to identify the correction factor between the reagents for CT measurement on the LiaisonXL and Cobase 601 assays (immunochemiluminescence, respectively electro-immunochemiluminescence)....

ea0070aep926 | Thyroid | ECE2020

The value of contrast-enhanced 18F-FDG PET/CT for indication of loco-regional surgery in radioiodine-refractory differentiated thyroid cancer

Koranda Pavel , Mocnakova Marketa , Frysak Zdenek , Hudson Lenka

Aim/Introduction: Contrast-enhanced 18F-FDG PET/CT is an effective diagnostic procedure enabling a precise localization of remnants or recurrences in patients with radioiodine-negative differentiated thyroid carcinomas (DTCs). The detection of this lesions allows to cure patients without detectable distant metastases using a loco-regional surgical treatment. The aim of this study was to assess the influence of 18F-FDG PET/CT on indication of this type of ...

ea0070aep927 | Thyroid | ECE2020

Association between multifocality and one-year post-surgery response to treatment in papillary thyroid cancer

Monzón Mendiolea Andoni , Paja Fano Miguel , Leyre Martínez Martínez Adela , Merlo Pascual Ignacio , Araceli Calles Romero Laura , Covadonga Iglesias Hernández Natalia , Oleaga Alday Amelia

Introduction: American Thyroid Association (ATA) guidelines suggest considering hemithyroidectomy in patients with unifocal well-differentiated thyroid tumours,smaller than 4 cm, withoutpreoperative evidence of extrathyroidal extension (ETE) nor lymph node metastases. Although multifocal microcarcinomas are considered to increase the risk of structural disease recurrence from 1%–2% to 4%–6% compared to unifocal microcarcinomas, the ATA guidelines do not sugges...

ea0070aep928 | Thyroid | ECE2020

Usefulness of tissular heterogeneity analysis measured by elastography in the characterization of tyroid nodules

Sevillano Jiménez Maria , Ravé García Reyes , Socorro García García Clara , Torres Cuadro Alberto , Asunción Martínez Brocca María , Martín Hernández Tomas

Objectives: To assess whether the degree of heterogeneity of thyroid nodules defined by their elastographic characteristics is related to the cytological diagnosis and ultrasound classification of risk of malignancy.Material and Methods: Observational, prospective study. 101 thyroid nodules were analysed by quantitative elastographic analysis (shear-wave), measuring the stiffness of the lesion by global elastography and its standard deviation (s.d.</...

ea0070aep929 | Thyroid | ECE2020

No important salivary gland damage following radioiodine remnant ablation

Krcalova Eva , Horacek Jiri , Gabalec Filip , Zak Pavel , Dolezal Jiri

Radioiodine (131I, RAI) has traditionally been used in thyroid cancer treatment but its benefitshould be balanced against possible risks. Among them, salivary gland dysfunction has oftenbeen discussed, although the reported data have been inconsistent. While some authors reported functional changes following higher (mostly cumulative) activities, there have been scarce data on the activity of 3.7 GBq (100 mCi) that is most commonly used for RAI remnant ablation...

ea0070aep930 | Thyroid | ECE2020

Graves’ disease in assocation with metastatic malignant struma ovarii: A descriptive case

Lai Ray , Lim Brenda , Chiang Brenda , Chew Daniel

Introduction: Malignant struma ovarii is a rare disease, for which risk factors and prognostic features are not well-defined. We present a patient with concomitant Graves’ disease and metastatic follicular thyroid cancer arising from struma ovarii, and discuss the possible mechanism of this association.Clinical case: A 43 year old woman undergoing follow-up for Graves’ disease (GD) presented with an enlarging left lower abdominal mass. She ha...

ea0070aep931 | Thyroid | ECE2020

Evaluation of miRNA-222, –146b, –181b as possible diagnostic markers in patients with papillary thyroid carcinoma

Kondrotiene Aiste , Pamedytyte Daina , Simanaviciene Vaida , Dauksiene Dalia , Zvirbliene Aurelija , Kazokaite Mintaute , Klimaite Raimonda , Sarauskas Valdas , Daukša Albertas , Verkauskiene Rasa , Zilaitiene Birute

Introduction: The sensitivity and specificity of biomarkers which have been used in clinical practice for diagnosis of papillary thyroid carcinoma (PTC) are low. It is essential to develop novel diagnostic biomarkers for PTC.Objective: We aimed to explore the expression levels of miR-222, – 146b, –181b in PTC tissue and plasma samples and to compare with benign thyroid nodules (BTN).Methods: We collected plasma samples ...

ea0070aep932 | Thyroid | ECE2020

Comparative assessment of several ultrasound imaging systems

Aleksandrov Yuriy , Yanovskaya Elena , Timofeeva Lubov

The purpose of the study was to evaluate the diagnostic capabilities of systems for assessing ultrasound thyroid imagines. The object of the study was 754 patients with thyroid nodules. Research methods: ultrasound in the framework of image evaluation systems TIRADS, EU-TIRADS, ARC-TI-RADS, BTA, TI-RADS K. For statistical analysis of systems and criteria was performed multidimensional statistical modeling using cluster, factor, discriminant, variance, and ROC analysis. The stu...

ea0070aep933 | Thyroid | ECE2020

Thyroid hormone resistance and succesful gestation with unaffected fetus: A case report

Eugenia López Valverde María , Manzanares Cordova Rossana , Rodriguez Pilar , Inés Velasco López María

Thyroid hormone resistance (THR) is a rare dominantly inherited syndrome characterized by a reduced response of target tissues to thyroid hormone receptor. In most cases, THR is related to mutations in the thyroid hormone receptor beta gene (THRb). Management may be challenging in cases of gestation. Here we report the case of a pregnant patient with a possible not previously described mutation and negative genotype fetus.Case report: Thirty-two year old...

ea0070aep934 | Thyroid | ECE2020

Myasthenia gravis associated with Graves’ disease: About three cases

Majdoub Marwa , Rojbi Imen , Mekni Sabrine , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

Introduction: The coexistence of Grave disease [GD] and Myasthenia gravis [MG] may present a diagnostic dilemma especially concerning ocular manifestations. 3–10% of myasthenic patients exhibit GD, while MG is reported in only <1% of patients with thyroid disorder.Observation:Case 1: A 32-year-old woman, with a medical history of vitiligo, was diagnosed with GD. Immunology revealed positive anti-thyroid peroxidase antibod...

ea0070aep935 | Thyroid | ECE2020

Thyroglossal duct cyst papillary thyroid cancer in a 40-year-old female: Case report

Dabrowska Anna , Dudka Jaroslaw

Introduction: The thyroglossal duct develops during thyroid gland formation and usually involutes at 7–10 weeks gestation. Its residue can lead to formation of cysts as well as to develop neoplasms within the mass.Case report: A 40-year-old woman was admitted to Department of Otolaryngology because of an enlarging midline neck mass for the last few months, without other worrisome symptoms. A neck ultrasound and CT scan showed a cystic lesion with s...

ea0070aep936 | Thyroid | ECE2020

Primary percutaneous coronary intervention induced thyroid storm and acute coronary syndrome: A case report

Bjekic Macut Jelica , Zdravkovic Marija , Vukasin Tamara , Ivanovic Nebojsa , Crevar-Marinovic Slobodanka , Sasa Hinic

Background: Thyroid storm is an extreme disorder that occurs in case of severe thyrotoxicosis. This is a life-threatening condition with mortality rates up to 10–20%. A typical dose of iodinated contrast media (ICM) contains approximately 13.500 µg of free iodide and 15 to 60 g of bound iodine, which represents an acute iodide load of 90 to several hundred thousand times the recommended daily intake of 150 µg. As a result of sudden exposure to high iodide loads...

ea0070aep937 | Thyroid | ECE2020

Hashimoto’s thyroiditis in a patient with IgG4 related disease

Husnina Matali Nur , Lin Chong Pui

Introduction: Immunoglobulin G4 related disease (IgG4-RD) is an immune-mediated fibro-inflammatory condition and is a widely recognised multi-organ system disease. The prevalence of IgG4-RD is 6/100 000, but it is likely to be underestimated. IgG4-RD is characterised by elevated serum levels of IgG4 and IgG4-positive lymphoplasmacytic infiltrative lesions in the body. Recent reports suggest disease involvement in various organs including thyroid and orbital tissues. Thyroid di...

ea0070aep938 | Thyroid | ECE2020

Severe hypothyroidism secondary to Hashimoto’s thyroiditis and its implications for surgery

Yu Xinming , Soong Elaine , Li Mengye , Majeed Joohi

Background: The prevalence of hypothyroidism is around 1–2% in the UK. Hashimoto’s thyroiditis is thought to cause 0.1–2% of overt disease and 10–15% of subclinical hypothyroidism. This case presents a patient with severe hypothyroidism, secondary to Hashimoto’s thyroiditis, found incidentally on a surgical admission. The case study discusses the challenges and management of severe hypothyroidism in the need for an acute surgical intervention....

ea0070aep939 | Thyroid | ECE2020

Cardiovascular clinical presentation of inpatients with overt hyperthyroidism – a retrospective study in 250 patients

Szterenlicht Yael M. , Frankel Meir , Tolkin Lior , Sylvetsky Noa , Munter Gabriel

Background: The clinical presentation of hyperthyroidism has been studied in the ambulatory caresetting. Our hospital performs a TSH test for all newly admitted patients.Aim: To describe the clinical presentation of patients with overt hyperthyroidism during hospitalization and to study the association between thyroid hormone levels and the clinical picture.Methods: A retrospective study of 250 hospitalized patients from an 11-year...

ea0070aep940 | Thyroid | ECE2020

Hyaluronan in part mediates IL-1beta-induced inflammation in human thyrocytes by up-regulating TLR-4 and CD44 receptors

Ruggeri Rosaria , Teresa Vicchio Maria , Campennì Alfredo , Campo Salvatore , Trimarchi Francesco , Cannavo’ Salvatore , D’Ascola Angela

Background: The expression of thyroid-specific genes [thyroglobulin (Tg) and sodium iodide symporter (NIS)] is modulated by several cytokines (IL-1, IFNγ, TGF-ß) and it is down-regulated in Hashimoto’s thyroiditis (HT). Also, lymphocytic infiltration and inflammation in HT results in intra-thyroidal accumulation of hyaluronan (HA). During inflammation, HA can be degraded into small fragments, able to up-regulate pro-inflammatory genes by stimulating the toll-li...

ea0070aep941 | Thyroid | ECE2020

Thyroid hormone levels is not associated with non-alcoholic fatty liver disease in euthyroid subjects

Jeong Kim Hye

Backgroud: Recent studies have shown an association between thyroid hormone levels and non-alcoholic fatty liver disease(NAFLD). However, there have been some inconsistencies between studies. Here, we evaluated the relationship between thyroid hormone levels and NAFLDin euthyroid subjects.Methods: A retrospective analysis of 27.719 euthyroid subjects who participated in comprehensive health examinations was performed. Subjects were grouped acco...

ea0070aep942 | Thyroid | ECE2020

Predictive value of free triiodothyronine within normal range on cardiovascular events in a Chinese cohort with coronary artery disease: Direct effect and mediation effect by TG

Wen Jun , Su Fei , Li Xuan , Wu Na-Qiong , Gao Ying , Liu Geng , Dong Qian , Tang Yi-Da , Li Jian-Jun , Guo Yuan-Lin

Background and aims: Coronary artery disease (CAD) plays an important role in global mortality worldwide. Risk assessment for patients with CAD through free triiodothyronine (FT3) remains unclear. Therefore, we aimed to investigate the impact of FT3 on the prognosis of patients with CAD.Methods: A total of 0 patients with CAD and available FT3 data, and without overt thyroid disease were enrolled in this study and grouped by tertiles. The primary outcome...

ea0070aep943 | Thyroid | ECE2020

Serum levels of myostatin in patients with hyperthyroidism or euthyroidism

Tseng Fen-Yu

Objective: Myostatin may negatively regulate skeletal muscle mass. Serum myostatin levels have positive associations with obesity and insulin resistance. Thyroid dysfunction may affect body weight, energy expenditure, and glucose metabolism. We evaluated the serum myostatin levels in different thyroid function statuses.Subjects and methods: We recruited 30 newly-diagnosed hyperthyroid (HY) patients and treated them with anti-thyroid regimens as clinicall...

ea0070aep944 | Thyroid | ECE2020

Hypercalcitonemia in a patient with micronodular goiter and adrenal nodular hyperplasia-diagnosis challenge

Nicoleta Cima Luminita , Soare Iulia , Lambrescu Ioana , Vadana Alexandra , Martin Sorina , Fica Simona

Introduction: Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma (MCT). Still, several physiologic and pathologic conditions other than MCT have been associated with increased levels of calcitonin, including neuroendocrine tumors that can ectopically secrete calcitonin.Case report: We present the case of a 78-year old female patient, incidentally diagnosed with multinodular goiter when performing Doppler ultrasou...

ea0070aep945 | Thyroid | ECE2020

MMP-9 1562 C/T polymorphism may be associated with an increased susceptibility to develop micropapillary thyroid cancer but not more advanced tumours

Dobrescu Ruxandra , Schipor Sorina , Picu Catalina , Manda Dana , Caragheorgheopol Andra , Badiu Corin

Background: Matrix metalloproteinase-9 (MMP-9) is an important mediator of invasion and metastasis in neoplasia. The single nucleotide 1562 C/T polymorphism in the promoter region of the MMP-9 genewas shown to increase gene expression and was studied as a susceptibility factor for various cancers.Aim: We aimed to evaluate the impact of the MMP-9 promoter genotype on the risk of developing papillary thyroid cancer (PTC) and to correlate cancer patient gen...

ea0070aep946 | Thyroid | ECE2020

Papillary thyroid cancer with biochemical incomplete response: Clinico-pathological characteristics and disease outcome

Steinschneider Miriam , Asly Mustafa , Markus Efrat , Koren Shlomit , Tkacheva Inna , Benbassat Carlos , Muallem-Kalmovich Limor , Hirsch Dania

Objective: Althoughmost Papillary Thyroid Cancer (PTC) patients with biochemical incomplete response (BIR) to primary therapy have a good clinical outcome, some will develop disease progression. We aim to study baseline characteristics and long-term outcomes of PTC patients with BIR.Methods: Of 1049 PTC patients treated at 2 tertiary medical centers, 795 (75.8%) had excellent, 91 (8.7%) biochemical incomplete, 139 (13.2%) structural incomplete and 24 (2....

ea0070aep947 | Thyroid | ECE2020

The outcomes of thyroglobulin monitoring by high-sensitivity tests after treatment of differentiated thyroid cancer

Makolina Natalya , Platonova Nadezhda , Troshina Ekaterina , Melnichenko Galina

The goal was todetermine the optimal methods of postoperative monitoring of serum thyroglobulin (Tg) in differentiated thyroid cancer (DTC). This research intended to compare the prognostic value of immunometric methods with different functional sensitivity (FS) for Tg measurement for detecting recurrent disease.Design: During 2010–2012 years, 76 patients with treated DTC (a total thyroidectomy and adjuvant radioiodine therapy) were included. All p...

ea0070aep948 | Thyroid | ECE2020

Next generation sequencing of 12-gene panel Molecular profiling of Thyroid cancer: An indian study

Bangaraiahgari Ramesh , Bhargav Panchangam Ramakanth , Mayilvaganan Sabaretnam , G Rakshith , B Rajesh , Md Rafi , Akshaya Ramesh D Lakshmi , V Akhila , Shetty M Shiran , T Shreshta , P Sweeya

Introduction: Next-generation sequencing (NGS) in thyroid cancer allows for high-throughput sequencing analysis of various genetic alterations and provides a useful information of tumor biology. NGS Studies on follicular differentiated thyroid cancer have been scantyfrom Indian subcontinent. In this context, we set out study the prevalence of a genetic panel wide somatic mutations in thyroid cancer.Material and Methods: This prospective study was conduct...

ea0070aep949 | Thyroid | ECE2020

Medullary thyroid cancer follow-up in a tertiary center

Apaydin Tugce , Imre Eren , Gogas Yavuz Dilek

Introduction: Although medullary thyroid cancer (MTC) constitutes 2–4% of all thyroid cancers, it is associated with higher mortality compared to differentiated thyroid carcinomas. Here we present long term clinical results of medullary carcinoma patients’ follow-up in our center.Methods and results: MTC was detected in 27 (3.73%) patients of 850 thyroid cancer cases who were followed-up between 2004 and 2020 at the Marmara University School ...

ea0070aep950 | Thyroid | ECE2020

Is Poorly diffentiated thyroid cancer a bridge between well differentiated and anaplastic cancer – Genomic perspective

Bhargav Panchangam Ramakanth , Bangaraiahgari Ramesh , Bangaraiahgari Rajesh , Md Rafi , Reddy B Rajkiran , Mayilvaganan Sabaretnam , G Rakshith , Akshaya Ramesh Devanapalli Lakshmi , Vemula Akhila , Shetty M Shiran , T Shreshta , P Sweeya

Introduction: Poorly differentiated thyroid cancer (PDC) is a relatively rare form of differentiated thyroid caner with intermediate prognosis between well differentiated (WDTC) and anaplastic cancers (ATC). But, this finding is debatable in literature. Genomics is the one of definitive modalities to resolve this conundrum. ATC tends to express P53 and KMT2D mutations frequently, while WDTC have no such mutations. Similar studies are scanty in PDC. In this context, we set out ...

ea0070aep951 | Thyroid | ECE2020

The importance of molecular-genetic examination in a patient with sonographically suspected but cytologically benign thyroid nodule

Laburda Milos , Vondra Karel , Pekova Barbora , Dvorakova Sarka , Sykorova Vlasta , Moravcova Jitka , Vaclavikova Eliska , kuklik Miloslav , Vcelak Josef , Bendlova Bela , Drozenova Jana

Introduction: Differential diagnosis of thyroid nodules is one of the most frequently solved problems in the endocrinological practice. It is always necessary to determine their biological nature, which will decide about further therapeutic procedure, especially about early surgery in case of proven malignancy. In addition to sonographic examination and fine needle aspiration biopsy (FNAB), now we can also use the possibilities of molecular-genetic examination.<p class="ab...

ea0070aep952 | Thyroid | ECE2020

Intraoperative navigation of the parathyroid glands in the surgical treatment of highly differentiated thyroid cancer

Vozdvizhenskii Mikhail , Orlov Andrey , Makhonin Aleksandr , Stadler Vladimir , Matyash Yana

Topicality: The most common cancer of the endocrine system is thyroid cancer. The main method of treatment for highly differentiated thyroid cancer is surgical.A special place among the complications of surgical treatment of thyroid cancer according to the severity of manifestation and the complexity of prevention is occupied by postoperative hypoparathyroidism.The purpose of the study.Minimize the risk of da...

ea0070aep953 | Thyroid | ECE2020

Diagnostic patterns of relapsed differentiated thyroid cancer (DTC) and the efficacy of rescue therapies (ERUDIT Study)

Sambo Marcel , Navarro Elena , Aller Javier , Guadalix Sonsoles , Zafón Carlos , González Cristina , Santamaría Javier , González Marcelino , Puig Manel , Galofré Juan C. , Argüelles Iñaki , Vallejo Juan A. , Pubul Virginia , Santos Rita , Llanos Marta , Crespo Guillermo , Segura Ángel , Navarro Miguel , Gajate Pablo , Valdivia Javier , López Carlos , Castelo Beatriz , Villanueva María J. , Araujo Fábia , Orcajo Lorenzo , Rodríguez-Villanueva Julio

Introduction: Advanced differentiated thyroid carcinoma (aDTC) – herein defined as locally unresectable or metastatic disease – is one of the most common late-stage endocrine neoplasias. However, available data about its natural history is limited. ERUDIT is a multicenter, observational, retrospective study of patients diagnosed with aDTC in Spain and Portugal. The study describes its natural history from the initial diagnosis until the advanced stages of disease, ...

ea0070aep954 | Thyroid | ECE2020

TNM 8th edition in thyroid cancer staging: Is there an improvement in predicting recurrence?

Cellini Miriam , Alice Manzardo Olimpia , Indirli Rita , Dolci Alessia , Colombo Paolo , Carrone Flaminia , Lavezzi Elisabetta , Mantovani Giovanna , Mazziotti Gherardo , Arosio Maura , Lania Andrea

TNM 8th edition introduces changes in the staging of patients with differentiated thyroid carcinoma (DTC). This study aims at assessing the ability of TNM 8th edition in predicting structural recurrence of DTC.480 DTC patients were retrospectively evaluated by 7th and 8th editions of TNM staging systems in relationship with risk stratification, response to therapy and recurrence of disease as defined by 2015 American Thyroid Association (ATA) guidelines. As compared to the 7th...

ea0070aep955 | Thyroid | ECE2020

A study of the relationship between RET/PTC and Cyclin D1 expression of the thyroid under autoimmune thyroiditis and Papillary thyroid carcinoma (PTC): Clinical-pathological correlation

Gvianishvili Tamuna , Gogiashvili Liana , Tsagareli Zurab , Velijanashvili Mariam

Our research subject is to study the importance of some favorable molecular biological markers for prognosis of premalignant characteristics of Hashimoto’s thyroiditis (HT) parenchyma. To clarify the pathogenetic link between these two pathologies (HT, PTC), we choose markers, indicating, at the one hand, on the tumor cell cycle, such Cyclin D1, at the second hand, RET/PTC rearrangement in HT, in order to determine molecular changes, connecting Hashimoto’s thyroidi...

ea0070aep956 | Thyroid | ECE2020

Medullary Thyroid Carcinoma (MTC); unusual metastatic sites. Two case reports

Kazakou Paraskevi , Simeakis George , Alevizaki Maria , Saltiki Katerina

Background: MTC tends to metastasize early in the course of the disease affecting usually regional lymph nodes; in 7–23% of patients distant metastases may be present at diagnosis (common metastatic sites:liver, lungs, bone). We present two MTC cases with unusual metastases to the breast, pancreas and mandible.Case presentation: Patient No 1A 48-year-old female was diagnosed with MTC in 1990. Total thyroidectomy was performed...

ea0070aep957 | Thyroid | ECE2020

A novel method for detecting autoantibody to wd repeat domain 1: Clinical application for differentiating papillary thyroid carcinoma with poor clinical outcome

Izawa Shoichiro , Matsuzawa Kazuhiko , Matsumoto Kazuhisa , Fukaya Kenji , Fukuhara Takahiro , Wakahara Makoto , Koga Atsuro , Hino Tomoya , Yamamoto Kazuhiro

Background: Papillary thyroid carcinoma (PTC) is known as the most common histological subtype of thyroid carcinoma. The prognosis of PTC is generally favorable. However, small number of patients with PTC progressed with distant metastasis and invasion to adjacent organs. New diagnostic tool for early detection of PTC with poor outcome is desired. We previously reported that autoantibody to WD repeat domain 1 (AWA) in the serum was associated with the existence of undifferenti...

ea0070aep958 | Thyroid | ECE2020

The profile of patients with hyperthyroidism at a tertiary health care center in the oriental region of northeastern Morrocco: – A study of 186 cases -

Ben Yakhlef Salma , Nada Derkaoui , Bouichrat Nisrine , Rouf Siham , Latrech Hanane

Introduction: Hyperthyroidism is characterised by an increased hormone synthesis, with non-specific and pleomorphic clinical features. Management strategy, depends entirely on the etiological status ; as part of an holistic vision. The purpose of this study is to shed light on epidemiological, clinical, etiological and therapeutic aspects of hyperthyroidism in Endocrinology & Diabetology department of Oujda’s Mohammed VI university hospital.<p class="abstext...

ea0070aep959 | Thyroid | ECE2020

Features of large intestinal microbiota of patients with hypothyroidism

Piddubna Antonina , Pashkovska Nataliia , Koval Galina , Pankiv Ivan , Marchuk Yulia , Abramova Nataliia , Tsaryk Iryna

Introduction: The prevalence of manifest hypothyroidism by various data is 0.2–2%, sub-clinical – up to 3% in men and up to 10% in women, and in people over 70 years old – 13–14%. The presence of concomitant gastrointestinal diseases significantly limits the possibility of hypothyroidism compensation; these patients need higher doses of levothyroxine. According to a number of researchers, hypothyroidism is often accompanied by small intestinal bacterial...

ea0070aep960 | Thyroid | ECE2020

Comparative characteristics of NAD(P) – dependent dehydrogenases in blood lymphocytes and neutrophils in patients with Graves’ disease

Dudina Margarita , Dogadin Sergey , Savchenko Andrey , Gvozdev Ivan

Background: Thyroid hormones participate in maturation, differentiation and triggering of immunity, but little is known about the modulating role of thyroid hormones on intracellular enzymatic reactions of immune cells and their role in immunopathogenesis of Graves’ disease (GD).Methods: The activity of NAD(P)-dependent dehydrogenases in lymphocytes and neutrophils ofperipheral blood was studied in a group of 145 women with GD, 53 (36.5%) pati...

ea0070aep961 | Thyroid | ECE2020

Chronic autoimmune thyroiditis and hypovitaminosis D – mammary eco-structural implications

Seila Ibadula , Olesea Scrinic , Eduard Circo

Introduction: Benign breast disease is the most common reason for senology consultation.Objectives: To investigate the possible involvement of thyroid autoimmunity and hypovitaminosis D in the development of mammary echo-structural lesions.Method: The BI-RADS score was assigned to categories 1–4 characteristic of benign mastopathy, in three groups of patients: Group 1 (n=167) – with chronic autoimmune thyro...

ea0070aep962 | Thyroid | ECE2020

Renal malfunction in patients with primary hypothyroidism

Didushko Oksana , Cherniavska Iryna

Aim: Study the correlation between leptin and renal malfunction in patients with primary hypothyroidism (PH).Methods: 161 patients suffering from PH took part in the investigation. Criteria of choice were as follows: patients’ age from 36 to 60 and presence of PH. Presence of any acute or chronic renal disease or ischemic heart disease was the criteria of exclusion. The diagnosis was made on the basis of complaints, family history, typical clinical...

ea0070aep963 | Thyroid | ECE2020

The possibilities of sonography in the diagnosis of thyroid nodules

Aleksandrov Yuriy , Belyakov Ivan , Sokolova Ekaterina

Purpose: To study the possibilities of sonoelastography (SEG) in the diagnosis of thyroid tumors. Materials and methods: in 123 patients (27 with papillary thyroid cancer, 45 with thyroid adenomas, and 51 with colloid goiter), different versions of SEG were used at the preoperative stage: compression sonoelastography (CEG) and point shear wave elastography (ARFI). Together with the staining assessment, quantitative parameters were determined: the speed of the transverse wave (...

ea0070aep964 | Thyroid | ECE2020

Efficacy & safety of total thyroidectomy as preferred primary treatment option for Graves’ disease

Mallette Katlin , Christian Francis , Caspar-Bell Gudrun

Graves’ disease is a common autoimmune condition, and the most common cause of hyperthyroidism. A number of definitive treatment options for this disease exist, including radioiodine (RI) and surgery. Surgery is often reserved for patients for whom RI is contraindicated or who have previously failed other treatments, including radioactive iodine ablation (RIA). The aim of this study was to assess the efficacy and safety of total thyroidectomy at our institution as a pref...

ea0070aep965 | Thyroid | ECE2020

Constitutive activation of Nrf2 antioxidant pathway leads to age-dependent goiter and compensated hypothyroidism in mice

Chartoumpekis Dionysios , Ziros Panos , Renaud Cédric , Bongiovanni Massimo , Habeos Ioannis , Liao Xiao-Hui , Refetoff Samuel , Kopp Peter , Brix Klaudia , Sykiotis Gerasimos

Background: KEAP1 gene (Kelch-like ECH-associated protein 1) that encodes the main inhibitor of nuclear factor erythroid 2-related transcription factor 2 (Nrf2), a central mediator of antioxidant responses, has been found to be one of the mutated genes that lead to familial multinodular goiter (MNG). The proposed association of KEAP1 with familial MNG is based on only two loss-of-function mutations in respective Japanese families. To date, there is no experim...

ea0070aep966 | Thyroid | ECE2020

Low serum IL-17A in pregnancy during second trimester is associated with an increased risk of subclinical hypothyroidism

Yang Qian , Li Xiaoying , Liu Jun , Zha Bingbing

Problem: Interleukin-17A (IL-17A) has a role in sustaining normal pregnancy. IL-17A isalso associated with thyroid autoimmunity during pregnancy. This study sought to investigate whether IL-17A is a risk factor for thyroid dysfunction during pregnancy without thyroid autoimmunity.Methods of study: The study comprised 216 pregnant women with negative thyroid peroxidase antibody (TPOAb) andthyroglobulin antibodies (TGAb) during the second trimesterwho prov...

ea0070aep967 | Thyroid | ECE2020

Management and outcomes of graves’ disease – a retrospective audit

Soong Elaine , Phoo Mon Kyaw Myat , Majeed Joohi

Background: Graves’ disease is a common cause of thyrotoxicosis,especially amongst females. In the UK,initial treatment is usually with anti-thyroid drugs, using either a ‘block and replace’ or a titrating regime. A meta-analysis suggests about 50% chance of relapse after the initial course of treatment and may then require definitive cure with radioactive iodine or surgery.Method: A retrospective audit of patients with Graves’ di...

ea0070aep968 | Thyroid | ECE2020

Evaluation of 24-hour electrocardiogram parameters in patients with graves disease before and after anti-thyroid therapy

Akkus Gamze , Sokmen Yeliz , Yilmaz Mehmet , Bekler Ozkan , Akkus Oguz

Background: We aimed prospectively investigate the laboratory and electrocardiographic parameters (hearth rate, QRS, QT, QTc, Tpe, Tpe/QTc, arrhythmia prevalance) in patients with graves disease before and after antithyroid therapy.Methods: 71 patients (48 female, 23 male), age between 18–50 (mean ± s.d.: 36.48 ± 12.20) with GD were included into the study. Patients treated with antithyroid therapy (thionamids and/or surgical the...

ea0070aep969 | Thyroid | ECE2020

Reducing unnecessary thyroid fine needle aspiration using ACR--TIRADS system

Alhambra Expósito Mª Rosa , Barrera-Martín Ana , Rebollo-Román Ángel , Segui-Azpilcueta Pedro , Ángeles Gálvez-Moreno María

Introduction: Thyroid ultrasound is the main technique to study this gland’s pathology. ACR TI-RADS system evaluates the malignancy risk in thyroid nodules according to their sonographic features and stablishes the size in which to perform fine needle aspiration (FNA) for its cytological study. Nodules diagnosed as Bethesda category 4 (B4) means are follicular neoplasms or suspicious for follicular neoplasms.Aim: Determine the pathology diagnosis o...

ea0070aep970 | Thyroid | ECE2020

Falsely elevated FT4 measurements with an electrochemiluminescent assay

Pappa Athina , Ilias Ioannis , Kakoulidis Ioannis , Koukkou Eftychia

Introduction: Recently Roche Diagnostics (Rotkreuz, Switzerland) introduced the third generation of its Elecsys free thyroxine (FT4 iii) assay (in Greece from February 2019 onwards). The new assay is considered to have reduced biotin interference compared to its previous version (Ft4 ii). Kits of the FT4 ii assay are still available (and valid) according to the manufacturer’s expiration date. Using the FT4 ii assay per the manufacturer’s instructions we noticed FT4...

ea0070aep971 | Thyroid | ECE2020

Role of thyroid ultrasonography in egyptian patients with hashimoto`s thyroiditis; a pilot study

William Z. Hanna Hany , El Haddad Hemmat E. , Salam Randa , Abdel Halim Radwa M , Rizzo C. , Abou-Youssef Hazem S.

Background: Hashimoto’s thyroiditis (HT) is considered the most common autoimmune disease and the predominant cause of hypothyroidism in iodine sufficient countries. HT may appear clinically in approximately 0.1–2% of the population.Aim: The study in hand aimed at assessing the role of thyroid ultrasonography in the diagnosis of HT patients discriminating them from other causes of hypothyroidism. A scoring system of sonographic findings was a...

ea0070aep972 | Thyroid | ECE2020

Determinants of the health related quality of life of adult filipinos with differentiated thyroid cancer

Bernardo Diane , Jimeno Cecilia , Jason Li Ralph

Objective: This study aims to investigate clinical and demographic variables associated with HRQoL as measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core Questionnaire (EORTC QLQ C30) Tagalog and the Thyroid Cancer-Specific Quality of Life Questionnaire (TCS QLQ) Tagalog.Methodology: 234 adult Filipinos with histopathologic-confirmed diagnosis of DTCafter thyroidectomy with or without radioactive ...

ea0070aep973 | Thyroid | ECE2020

Diagnostic value of Bethesda system for reporting thyroid cytopathology in patients with prior thyroid surgery

Faki Sevgul , Karahmetli Gulsum , Kilic Yazgan Aylin , Kiliç Mehmet , Topaloglu Oya , Ozdemir Didem , Ersoy Reyhan , Cakir Bekir

Background: Fine needle aspiration biopsy (FNAB) and Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) have proven to be the most valuable diagnostic procedure for preoperative discrimination of benign and malignant thyroid nodules. Thyroid surgery may cause regional scarring and some degree of fibrotic process which may result in problems when collecting FNAB samples and evaluating the cellular abnormalities. In this study, we aimed to determine whether the Bethesd...

ea0070aep974 | Thyroid | ECE2020

Humoral changes during resolution of short term severe hypothyroidism

Gergics Marin , Pham-Dobor Greta , Horváth-Szalai Zoltán , Kőszegi Tamás , Mezosi Emese , Bajnok Laszlo

Introduction: Significant hyponatremia may evolve in hypothyroidism, when however, elevated ADH levels have not been consistently demonstrated. On the other hand, it was shown that thyroid hormone substitution suppresses ADH, and its surrogate marker copeptin secretion. The aim of our present study was to investigate the possible humoral changes in a special model of resolution of short term severe hypothyroidism in differentiated thyroid cancer (DTC) patients.<p class="ab...

ea0070aep975 | Thyroid | ECE2020

The concordance between ultrasonographic EU-TIRADS and cytologic bethesda criteria of thyroid nodules

Laukiene Romena , Sileikaite Kotryna

Objective: The aim of this study was to evaluate the capability of the thyroid nodule ultrasonography criteria of the European Thyroid Imaging and Reporting Data System (EU-TIRADS) to predict fine needle aspiration cytology results categorised by The Bethesda system.Methods: A retrospective analysis was made out of 310 cases of an outpatient clinic over a period of 1 year (2018.03–2019.03). We compared single-specialist-performed thyroid nodule ult...

ea0070aep976 | Thyroid | ECE2020

Association of a medullary thyroid carcinoma, a papillary thyroid carcinoma and a renal carcinoma: Towards a new neoplastic syndrome?

Halloul Imen , Mensi Sihem , Ezzine Abir , Marzouk Hajer , Dardouri Tahani , Ben Fredj Maha , Nouira Manel , Chatti Kawthar

Introduction: Multiple primary cancers are a rare entity; however their incidence is increasing due to advances in diagnostic methods and surveillance strategies. The coexistence in the same patient of several primary malignant tumors has been described in the literature with a frequency varying from 5.5% to 8.5%.The aim of this observation is to report a case associating 3 neoplasias:medullary thyroid carcinoma (MTC), papillary thyroid carcinoma (PTC) a...

ea0070aep977 | Thyroid | ECE2020

Risk factors of disease recurrence among Filipino patients with low-risk papillary thyroid carcinoma in manila doctors hospital: A retrospective cohort study

Hernandez Edrome , Eunice Lustestica Kaye , Erika Rubion Lou , Nicodemus Nemencio

Background: New emerging studies demonstrated that mortality from thyroid cancer and disease recurrence was significantly higher among Filipinos compared with other ethnic groups. However, exact mechanisms which could explain these findings among Filipino patients remain to be poorly understood. The risk factors associated with disease recurrence among adult Filipino patients with low-risk papillary thyroid cancer in Manila Doctors Hospital was assessed in this study.<p cl...

ea0070aep978 | Thyroid | ECE2020

Large ‘forgotten goiter’ in the thoracic cavity – a case report

Paczkowska Katarzyna , Rolla Małgorzata , Elbaum Michał , Jędrzejuk Diana , Bolanowski Marek , Daroszewski Jacek

Introduction: ‘Forgotten goiter’ is defined as a mediastinal thyroid mass discovered after total thyroidectomy. It is a rare clinical finding, usually asymptomatic.Case report: 88-years old woman was admitted to the Endocrinology Department with a suspicion of the retrosternal goiter. In her medical history there was thyroidectomy performed 16 years before because of multinodular goiter and she had recurrent lower respiratory tract infections...

ea0070aep979 | Thyroid | ECE2020

Primary Thyroid Teratoma – a rare diagnosis

Mourinho Bala Nádia , Guerra Sílvia , Cordeiro Raposo Nuno , Oliveira Helena , Madureira Rosa , Valadas Cristina

Introduction: A teratoma is a rare type of tumor deriving from the germ layer cells (ectoderm, mesoderm and endoderm), typically benign, more frequent in infants. Adult onset teratomas are most commonly gonadal cell tumors. Extra--gonadal teratomas generally affect the midline, most frequently anterior mediastinum, retroperitoneum, pineal and suprasellar area. Head and neck teratomas are an extremely rare entity and represent only 0.47–6% of all cases.<p class="abste...

ea0070aep980 | Thyroid | ECE2020

Secondary intrathyroid localization of a pulmonary papillary carcinoma

Hasnaoui Mehdi , Masmoudi Mohamed , Belaid Takwa , Mighri Khalifa

Introduction: Intrathyroid metastases are rare (less than 1% of thyroid cancers). They can be synchronous or metachronous. The origin of primary cancer is variable; the kidney, lung, stomach and breast being the most described sites.Through this case, we describe the diagnostic difficulties that the pathologist may encounter in the identification of these metastases.Materials and methods: We report a case of intrathyroid metastasis...

ea0070aep981 | Thyroid | ECE2020

Rhabdomyolysis from severe hypothyroidism – A case report

Haxhiraj Adela , Hoxha Violeta , Husi Gerond , Shehaj Larisa , Bolleku Erjola , Ylli Agron

Introduction: Hypothyroidism can cause various degrees of muscular disorders. It can lead to symptoms such as myalgia, weakness, fatigue and in rare cases to extreme muscular damage such as rhabdomyolysis, a potential life-threatening complication. We present the case of a 53 years old patient with acute renal failure due to rhabdomyolysis from severe hypothyroidism.Case description: The patient, a male from Albania was first admitted to the Emergency Ro...

ea0070aep982 | Thyroid | ECE2020

Exophtalmos in a hyperthyroid patient – it’s not always Graves ophthalmopathy

Martin Sorina , Mustata Theodor , Predescu Andrada , Fica Simona

Background: Hyperthyroidismcan be associated withorbitopathy that manifests as exophtalmos due to orbital tissue inflammation. Usually the diagnosis is straight forward when an autoimmune thyroid disorder is present, but conditions mimicking Graves orbitopathy can pose a diagnostic challenge.Case report: We report the case of a 51 year old caucasian woman who was referred to our clinic with asymmetrical exophtalmos in november 2019. The patient stated th...

ea0070aep983 | Thyroid | ECE2020

Hurthle cell carcinoma – A case report

Tare Rajmonda , Lumi Ema , Puca Entela , Lapardhaja Adriana , Toti Florian

Introduction: Hurthle cell carcinoma was considered to be a variant of follicular thyroid cancer. However, recent clinical and molecular studies clearly indicate that Hurthle cell cancer is a distinct tumor type. Histologically, it is characterized by the presence of a cell population of ‘oncocytes’, mostly eosinophilic oxyphilic cells and abundant cytoplasm,closely packed mitochondria, and round oval nuclei with prominent nucleoli. Unlike follicular thyroid cancer...

ea0070aep984 | Thyroid | ECE2020

The flight of the thyroid- the butterfly effect

Kapoor Ashutosh

Introduction: Dual nivolumab and ipilimumab immunotherapy has the potential of causing an immune-mediated thyrotoxicosis, precipitating thyroid storm.Case details: A 62-year-old Caucasian woman with a history of Lung Carcinoma (Non small Cell Lung Carcinoma) presented to the emergency department, with a 3-day history of intractable nausea, severe headache, vomiting and anxiety.She had been initiated on dual nivolumab and ipilimumab...

ea0070aep985 | Thyroid | ECE2020

A correlation study between histological results and thyroid ultrasound findings. The EU TI-RADS classification

Masmoudi Mohamed , El Omri Malika , Hasnaoui Mehdi , Lahmar Rihab , Mighri Khalifa , Driss Nabil

Introduction: The management of patients with nodular goiter and thyroid neoplasms is one of the most important problems in modern thyroidology. There are several classifications based on thyroid ultrasound for selecting suspected malignant thyroid nodules. The Thyroid Imaging Reporting and Data System (TI-RADS) classification is an easy to apply for thyroid lesions, which might be helpful in clinical practice for the initial assessment of the thyroid lesion risk of malignancy...

ea0070aep986 | Thyroid | ECE2020

A retrospective 5-year follow-up study on the outcomes of radiofrequency ablation for the treatment of benign thyroid nodules

Zuolo Giulia , Giudici Fabiola , Marco Cavallaro , Calabrò Veronica , Bruno Fabris , Stacul Fulvio , Bernardi Stella

Background: During the last decade, radiofrequency ablation (RFA) has emerged as a reliable alternative to surgery for the treatment of benign symptomatic thyroid nodules in terms of effectiveness and safety.Aim: The aim of this study were: (i) to evaluate the long-term efficacy (5 years) of RFA for the treatment of benign thyroid nodules, in terms oftechnical success and nodule regrowth, and (ii) to identify the predictive factors of t...

ea0070aep987 | Thyroid | ECE2020

Is there a place for Thyroid Scintigraphy with Technetium 99 m in the exploration of congenital hypothyroidism in the absence of Iode 123

Mensi Sihem , Halloul Imen , Ezzine Abir , Sfar Raja , Nouira Manel , Chatti Khawther

Introduction: With a prevalence of about one in 3000 newborns, congenital hypothyroidism (CH) is the leading cause of preventable mental retardation and growth failure. The objective of this work is to clarify the contribution of thyroid scintigraphy (TS) using technetium 99 m for the diagnosis of CH and this through the experience of the nuclear medicine department in Sahloul university Hospital.Materials and methods: This is a retrospective study inclu...

ea0070aep988 | Thyroid | ECE2020

Clinical scoring systems fare poorly among elderly patients in diagnosing primary hypothyroidism

Singla Varun , John Mary , Jagan Jacob Jubbin

Background: Clinical scoring systems were used traditionally in the diagnosis of hypothyroidism before biochemical diagnosis became the norm. There are two well validated clinical scoring systems (Billewicz and Zulewski) for diagnosing hypothyroidism. Both these scores were validated in younger patients with hypothyroidism and may not be useful in older patients. We conducted this study to determine the clinical utility of these two scoring systems among patients over the age ...

ea0070aep989 | Thyroid | ECE2020

Effect of cholecalciferol treatment on insulin sensitivity in patients with chronic autoimmune thyroiditis

Pankiv Volodymyr , Yuzvenko Tetiana

Background: Effects of vitamin D on immune cells might affect diabetes mellitus (DM) development since inflammatory factors have been linked to insulin resistance (IR). The aim of this study was to investigate the effect of cholesterol treatment on insulin sensitivity metabolic markers in patients with chronic autoimmune thyroiditis.Materials and methods: In this double-blind, randomized, placebo-controlled trial, which was conducted from May to Septembe...

ea0070aep990 | Thyroid | ECE2020

The introduction of endoscopic techniques in thyroid surgery

Radziyeuski Igar

Introduction: Endoscopic surgery has found wide application in many areas of medicine in a short: endocrinology is no exception. The main advantages of endoscopic access to the thyroid gland are the possibility of conducting endovideoscopy, a low traumatic surgical intervention, shortening of the inpatient treatment duration, periods of incapacity for work, and cosmetic effectsGoal: Determine the appropriateness of using endoscopic technologies in compar...

ea0070aep991 | Thyroid | ECE2020

Efficacy of radioactive iodine in treatment of graves’ disease

Varma Buddharaju P , kalawat Tekchand , Ganta Sandeep , patil Avinash , Deepthi Mani , K Raghavendra , V Suresh , Sachan Alok

Background: Radioactive iodine 131I (RAI) treatment is an effective definitive treatment of hyperthyroidism, used as a first line or second line treatment.Aims and objectives1. To evaluate the response of RAI therapy in Graves’ disease.2. To determine any factors predicting treatment failure.Study design: Retrospective study: Materials and methods: Clinical ...

ea0070aep992 | Thyroid | ECE2020

Thyroid cancer recurrence risk after transplantation: Single center experience

Turhan İyidir Özlem , Gülsoy Kırnap Nazlı , Pınar Altay Feride , Kırnap Mahir , Bașcıl Tütüncü Neslihan , Haberal Mehmet

Introduction: There is little data about the influence of immunosuppression on the recurrence rate of thyroid cancer. We aimed to evaluate the risk of recurrence and mortality of thyroid cancer after solid organ transplantation.Patients and Methods: We retrospectively evaluated 802 kidney and 283 liver transplant recipients who underwent transplantation between January 1999 and May 2019 in Bașkent University. We identified 14 patients with thyroid c...

ea0070aep993 | Thyroid | ECE2020

125I radioactive seed localization (RSL) in surgery of cervical metastasis of thyroid cancer

Jesús García González Juan , Martín Hernández Tomás , Domínguez Rabadán Rocío , Reyes Ravé García María , Rodríguez Vera Pablo

Introduction: The aim of this work is the evaluation of usefulness of radioactive seed localization (RSL) for the detection of cervical recurrence of thyroid cancer in order to improve the surgical outcome.Material and method: Six patients with thyroid cancer with cervical recurrences evidenced by ultrasound, cytology/Tg-FNAB were selected for this procedure. A 125I seed was placed in the metastatic lesion using a needle guided by ultrasound. ...

ea0070aep994 | Thyroid | ECE2020

Cystic cervical lymphadenopathy revealing thyroid papillary carcinoma

Hasnaoui Mehdi , Masmoudi Mohamed , Belaid Takwa , Mighri Khalifa

Introduction: Cervical lymphadenopathy is a frequent reason for ENT consultation. In most cases the diagnosis is easy based on clinical, radiological and cytopathological data. However, in some situations, the diagnosis remains pending. The objective of this work is to study the possible difficulties face to a chronic cystic cervical lymphadenopathy.Materials and methods: It is a retrospective study bringing 4 cases of cervical cystic lymphadenopathy rev...

ea0070aep995 | Thyroid | ECE2020

Performance of a dual-component molecular assay in cytologically indeterminate thyroid nodules

Sponziello Marialuisa , Verrienti Antonella , Pecce Valeria , Abballe Luana , Grani Giorgio , Ramundo Valeria , Fadda Guido , Brunelli Chiara , Durante Cosimo , Filetti Sebastiano

Background: Deciding whether patients with a cytologically indeterminate thyroid nodule should be referred for surgery or for active surveillance is an important challenge for clinicians. The aim of this study was to evaluate the performance of a novel dual-component molecular assay as an ancillary molecular method for resolving indeterminate thyroid nodule cytology.Methods: We selected 156 thyroid nodules from those that had undergone both FNA cytology ...

ea0070aep996 | Thyroid | ECE2020

Comparison of therapeutic radioiodine dose to ablation response in differentiated thyroid cancer patients with cut-off serum thyroglobulin level after two weeks of levothyroxine withdrawal

SONG Heesung , Young Lee Ji

Purpose: This retrospective study is evaluated the efficacy of three doses of I-131 (1110 MBq vs 3700 MBq vs 5550 MBq) in differentiated thyroid carcinoma patients with cut-off serum thyroglobulin (TG) level after two weeks of thyroid hormone withdrawal for postoperative thyroid remnant ablation.Methods: A total of 97 patients with differentiated thyroid cancer treated with total thyroidectomy and radioactive iodine (RAI) therapy...

ea0070aep997 | Thyroid | ECE2020

Case report: Myocardial Infarction after 9 month treatmentwith a tyrosine kinase inhibitor (TKI) with Anti-VEGF receptor activity

González Lázaro Paloma , Contreras Pascual Cristina , Montalbán Méndez Cristina , Moreno Tirado Antonio , Javier Gomez Alfonso Francisco , del Val Zaballos Florentino , Silva Fernández Julia , Gomez Garcia Ines

Introduction: TKIs including anti-VEGF receptor activity have been approved for the treatment of patients with radioiodine resistant thyroid carcinomas. For lenvatinib arterial thromboembolic events are listed as adverse events of special interest. In the phase III study of SELECT trial, arterial thromboembolic events were reported in 3% of lenvatinib-treated patients and 1% in the placebo group. Most of the patients had predisposing factors. Only one myocardial infarct was re...

ea0070aep998 | Thyroid | ECE2020

Mental health in children and adolescents with graves disease

Muratova Shakhlo

Aim: To study the thyroid and cognitive status and psycho-emotional health of children and adolescents with Graves’ disease (GD).Materials and methods: 37 children and adolescents with GD examined in the Republican Medical Center of Endocrinology (Uzbekistan). The control group consisted of 19 healthy children and adolescents. Thyroid status was determined using a closed-type immunochemistry analyzer Cobas e411 Hitachi from HoffmanLeRoche (Switzerl...

ea0070aep999 | Thyroid | ECE2020

Pembrolizumab inducing thyroid diseases: Are there differences between patients treated for lung carcinomas and those for lymphomas?

Lo Preiato Valentina , Buganè Anna , Casadei Beatrice , Salvagni Stefania , Argnani Lisa , Ardizzoni Andrea , Luigi Zinzani Pier , Pagotto Uberto

Background: In the last years, Pembrolizumab has been used to treat solid and lymphatic neoplasms, showing improved patients’ survival. Due to its mechanism of action, Pembrolizumab may be responsible of several immune-related adverse events (irAEs). The most frequent endocrine-irAEs reported are thyroid diseases.Aims: The aim of this study was to evaluate differences in thyroid disease incidence and presentation between patients treated for lung c...

ea0070aep1000 | Thyroid | ECE2020

Long-noncoding RAN negatively regulated by thyroid hormone to suppress tumorigenesis

Lin Kwang-Huei , Lin Yang-Hsiang , Wu Meng-Han

Long non-coding RNAs (lncRNAs) are a class of non-protein coding transcripts longer than 200 nucleotides that regulate complex cellular functions, such as cell growth, differentiation, metabolism, and metastasis. Thyroid hormone (T3) and its receptor (TR) are involved in cancer progression. To identify T3/TR-related lncRNAs that are differentially expressed in HCC, lncRNA expression profile screening was performed using the SYBR Green-based quantitative reverse transcription-P...