Hot topics (including COVID-19)

ea0070aep1001 | Hot topics (including COVID-19) | ECE2020

Obstructive sleep apnea in primary aldosteronism is associated with cortisol cosecretion

Heinrich Daniel , Adolf Christian , Handgriff Laura , Schneider Holger , Nirschl Nina , Obster Elisabeth , Sturm Lisa , Wang Xiao , Bidlingmaier Martin , Wildgruber Moritz , Ladurner Roland , Beuschlein Felix , Reincke Martin

Background: Primary aldosteronism (PA) is a secondary form of arterial hypertension that – in case of unilateral disease – can be cured by surgery. Multiple studies have shown that PA patients are at higher risk to suffer from cardiovascular events and to develop metabolic diseases. Two thirds of patients with PA suffer from obstructive sleep apnea (OSA). A bi-directional, pathophysiological interplay between OSA and PA has been proposed, with focus on overnight ro...

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ea0070aep1002 | Hot topics (including COVID-19) | ECE2020

Intact endothelial epoxyeicosatrienoic acids pathway in primary aldosteronism – the route to new treatment strategies?

Fruehbuss Laura , Meng Yao , Sun Jing , Gonzalez Marques Jair , Koletzko Berthold , Mederos Y Schnitzler Michael , Gudermann Thomas , Beuschlein Felix , Ann Williams Tracy , Heinrich Daniel , Adolf Christian , Reincke Martin , Schneider Holger

Rationale: Endothelial dysfunction (ED) is a hallmark of primary aldosteronism and paves the way for subsequent atherosclerotic disease. Past research has confirmed that one factor involved in ED is disturbed nitric oxide (NO) signalling. Since defects in NO release alone cannot explain the whole effect, we set out to address the role of endothelial CYP-expoygenase products (epoxyeicosatrienoic acids, EETs) in aldosterone-mediated endothelial dysfunction.<p class="abstext"...

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ea0070aep1003 | Hot topics (including COVID-19) | ECE2020

The NOS3 and CYBA gene polymorphisms are associated with subclinical atherosclerosis and arterial stiffness in premenopausal women

Armeni Eleni , Chatzivasileiou Panagiota , Stergiotis Stefanos , Rizos Demetrios , Kaparos Georgios , Augoulea Areti , Alexandrou Andreas , Georgiopoulos Georgios , Laina Aggeliki , Stamatelopoulos Kimon , Lambrinoudaki Irene

Introduction: Differences in the prevalence and prognosis of cardiovascular disease have been linked with gender specific risk factors as well as the differential impact of sex hormones. Moreover, specific genetic polymorphisms may increase further the risk of cardiovascular disease development. Polymorphisms of genes encoding the NADPH/NADPH oxidase system and the endothelial nitric oxide synthase (eNOS) have been associated with atherosclerosis in the general population, but...

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ea0070aep1004 | Hot topics (including COVID-19) | ECE2020

Impact of covid-19 pandemic on psychophysical stress in patients with adrenal insufficiency: The corti-covid study

Martino Marianna , Aboud Nairus , Fabio Cola Marco , Giancola Giulia , Ciarloni Alessandro , Salvio Gianmaria , Arnaldi Giorgio

Background: COVID-19 pandemic is a novel, potentially adverse condition for patients with adrenal insufficiency (AI), whose life expectancy and quality of life (QoL) are impaired due to their risk of infections and stress-triggered acute events. Therapeutic usefulness of glucocorticoids in COVID-19 is debated, but infected AI patients require prompt replacement tailoring.Objectives: In a cohort of AI patients, to assess:– the...

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ea0070aep1005 | Hot topics (including COVID-19) | ECE2020

Adrenal insufficiency at the time of COVID-19: A retrospective study

Carosi Giulia , Morelli Valentina , Del Sindaco Giulia , Cremaschi Arianna , Frigerio Sofia , Rodari Giulia , Indirli Rita , Liliana Serban Andreea , Profka Eriselda , Mungari Roberta , Resi Veronica , Orsi Emanuela , Ferrante Emanuele , Dolci Alessia , Giavoli Claudia , Arosio Maura , Mantovani Giovanna

Background: COVID-19 represents a global health emergency and infected patients with chronic diseases often present a severe impairment. Adrenal insufficiency (AI) is supposed to be associated with an increased risk of infections which could trigger adrenal crisis. Our primary aim was to evaluate the incidence of COVID-19 symptoms and complications in AI patients.Materials and methods: We conducted a retrospective case-control study, in 279 patients with...

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ea0070aep1006 | Hot topics (including COVID-19) | ECE2020

Variable mineralocorticoid function in autoimmune Addison’s disease – a case report

De Rop Jonas , Unuane David , Velkeniers Brigitte

Autoimmune Addison’s disease (AAD) is widely believed to be associated with total loss of endogenous mineralocorticoid and glucocorticoid production and secretion, due to cell-mediated immune destruction. Therefore, patients with AAD are prescribed lifelong mineralocorticoid and glucocorticoid replacement therapy. We present a case of a 69 year old women known with polyglandular autoimmune disease type 2 (hypothyroidism, Addison’s disease and premature ovarian fail...

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ea0070aep1007 | Hot topics (including COVID-19) | ECE2020

Testosterone levels were independently associated to sub-clinical atherosclerosis in men with chronic spinal cord injury

D’Andrea Settimio , Castellini Chiara , Totaro Maria , Parisi Antonio , Francavilla Felice , Francavilla Sandro , Barbonetti Arcangelo

Background: Men suffering from spinal cord injury (SCI) were at increased risk for cardiovascular diseases (CVD). SCI subjects showed an higher value of carotid intima media thickness (cIMT) at ultrasound, a surrogate markers of sub-clinical atherosclerosis. Furthermore, SCI men exhibited an higher prevalence of androgen deficiency compared to general population.Objectives: To investigate the relationship between total testosterone (TT) levels and cIMT i...

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ea0070aep1008 | Hot topics (including COVID-19) | ECE2020

The association between systolic blood pressure reduction during clonidine suppression testing and the decrease in plasma catecholamines and metanephrines

Golani Tiran , Fishman Boris , Sharabi Yehonatan , Olswang-Kutz Yael , Leibowitz Avshalom , Grossman Ehud , Shlomai Gadi

Background: Borderline isolatednorepinephrine (NE) and normetanephrine (NMT) elevation is common among patients with suspected pheochromocytoma and paraganglioma (PPGL). The clonidine suppression test (CST) may help establish the etiology in these cases. Prolonged laboratory processing and/or paucity of reliable biochemical assaysmay limit the utility of CST. The aim of this study was to evaluate whether blood pressure (BP) reduction during CST is associated with alterations i...

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ea0070aep1009 | Hot topics (including COVID-19) | ECE2020

Assessment of the awareness of cancer screening in patients with diabetes mellitus

ozkan Cigdem

Objective: Cancer is an important public health problem. Cancer screening is effective method in fight against cancer. In addition to an increased risk for cancer incidence there is some evidence in the literature reporting that patients with diabetes have a lower rate of cancer screening and survival than non-diabetic patients. In this study, we aimed to assess the awareness of cancer screening programmes in diabetic patients who admitted to our outpatient clinic.<p class...

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ea0070aep1010 | Hot topics (including COVID-19) | ECE2020

Clinical presentation variations of pheochromocytomas

Maria Lider Burciulescu Sofia , Livia Gheorghiu Monica , Bojoga Andreea , Badiu Corin

Introduction: Pheochromocytoma (PCC) has a wide spectrum of clinical manifestations, from insidious disease to extreme symptoms. Various mechanisms of catecholamine and other mediators actions were related to the diversity of PCC presentation.Aim: We describe a retrospective study, of patients with PCC from a tertiary hospital, focusing on clinical and biochemical characteristics of PCC depending on means of discovery.Material and ...

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ea0070aep1011 | Hot topics (including COVID-19) | ECE2020

A case of posaconazole associated adrenal insufficiency developing in the course of acute myeloid leukemia

Fevzi Degirmenciler Ridvan , Metan Gokhan , Ozcebe Osman , Gonul Iremli Burcin , Erbas Tomris

Posaconazole is a member of triazole antifungal family. It is frequently used prophylaxis and treatment in invasive fungal infections. Among the azole group antifungals, ketoconazole is well known to affect steroidogenesis through cytochrome P450 enzymes, however, posaconazole-induced adrenal insufficiency has been reported in only two cases in the literature. Here, we present our case of adrenal insufficiency induced by posaconazole.A 54-year-old male a...

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ea0070aep1012 | Hot topics (including COVID-19) | ECE2020

Subclinical atherosclerosis is associated with anti-mullerian hormone levels in reproductively women

Armeni Eleni , Stergiotis Stefanos , Chatzivasileiou Panagiota , Augoulea Areti , Anagnostis Panagiotis , Rizos Demetrios , Kaparos George , Alexandrou Andreas , Georgiopoulos Georgios , Kontogiannis Christos , Stamatelopoulos Kimon , Lambrinoudaki Irene

Introduction: The prevalence of cardiovascular disease in reproductively active women has received limited attention. Recent data indicated possible adverse effect of non-typical obstetrical risk factors with regards to cardiovascular function. We aimed to evaluate the potential association between anti-mullerian hormone (AMH), a known marker of ovarian reserve, with subclinical atherosclerosis in young premenopausal women.Methods: This was a cross-secti...

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ea0070aep1013 | Hot topics (including COVID-19) | ECE2020

A composite pheochromocytoma inneurofibromatosis type 1: A case report

Fatma Loukil , Sara Pinto , Sopio Tatulashivili , Lea Carlier , Helène Bihan

Introduction: The composite pheochromocytoma is a rare adrenal medullatumour that combines a pheochromocytome and a neuroblastic tumour. We present the case of a composite phenochromocytoma discovered in a patient with neurofibromatosis type 1.Case report: Patient aged 64 years referred to our department by his dermatologist for the exploration of a left adrenal mass discovered during the practice of a CT scan and then an 18F-FDG MRImade as part of an ex...

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ea0070aep1014 | Hot topics (including COVID-19) | ECE2020

Control of hypercorticism during paraneoplastic Cushing’s syndrome secondary to atypical carcinoid tumor of the lung (about one case)

Mezoued Mouna , Azzoug Said

Te paraneoplastic Cushing’s syndrome represents 9 to 18% of ACTH-dependent endogenous hypercorticisms; which poses, in clinical practice, two types of problems:– on the one hand, the differential diagnosis with Cushing’s disease, when well differentiated and morphologically undetectable endocrine tumors are involved.– on the other hand, the control of hypercortism, most often major in metastatic neuroendocri...

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ea0070aep1015 | Hot topics (including COVID-19) | ECE2020

Primary adrenal insufficiency secondary to COVID-19 infection: A case report

Gomes Porras Mariana , García Moreno Rosa , Zapatero Larrauri Myriam , Martin Rojas Patricia , Parra Ramírez Paola

Introduction: Bilateral adrenal hemorrhage (BAH) is a rare clinical condition (estimated incidence between 0.14% –1.8%, according to postmortem studies) and life-threatening due to the development of adrenal crisis, after the destruction of 90% of each adrenal gland. A mortality rate of 15% has been reported despite treatment, but it depends on the severity of the underlying condition, reaching 90% in cases of sepsis, or even higher if it is not diagnosed quickly enough....

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ea0070aep1016 | Hot topics (including COVID-19) | ECE2020

Clinical and hormonal features of the manifestation of various forms of congenital adrenal hyperplasia in children

Rudkova Ekaterina , Solntsava Anzhalika

Medical History of thirty five patients aged from one to sixteen years diagnosed with CAH have been analyzed in the Republican Center for Pediatric Endocrinology. Among the thirty five patients participating in the study (boys–fifty seven percent, girls –forty-three) seventy-one percent is with salt wasting form (SWF), twenty-two percent with virilising form (VF), three percent with non-classical form (NF). The mean weight SDS at birth is minus eight hund...

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ea0070aep1017 | Hot topics (including COVID-19) | ECE2020

Clinical aging manifestations of cortisol secreting adrenal adenoma

Alimoukhamedova Gulrukh , Khalimova Zamira

The objective was to study clinical aging peculiarities of manifestation period of cortisol secreting adrenal adenoma.Materials and methods: Forty five patients with cortisol-secreting adrenal adenoma served the basis for the study. In that group of patients there were 11 (24.4%) men and 34 (75.6%) women, with the average age 27.5 ± 10.5 years old. Out of forty five patients 5 (11.2%) were children. All patients had common clinical, biochemical, hor...

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ea0070aep1018 | Hot topics (including COVID-19) | ECE2020

18 Flour-Cholin-PET-CTis the supreme tool to localize ultrasound and mibi-’negative’ parathyroid adenomas – intraoperative correlation and 12 month postoperative results

Smaxwil Constantin , Philipp Aschoff , Mirjam Busch , Joachim Wagner , Julia Altmeier , Oswald Ploner , Andreas Zielke

Background: To characterize the diagnostic performance of 18-Fluoroethylcholine-PET-CT (FCH-PET-CT) to localize parathyroid adenomas (PA) in primary hyperparathyroidism (pHPT) when ultrasound (US) and MIBI-Scan (MibiS) fail to localize – intraoperative correlation and one-year follow up.Method: Beginning in 07/2017 18-FCH-PET was employed in patients with proven pHPT in whom US and MS delivered either incongruent or negative findings. All patients ...

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ea0070aep1019 | Hot topics (including COVID-19) | ECE2020

A global natural history study of Fibrodysplasia Ossificans Progressiva (FOP): 12-month outcomes

Mukaddam Mona Al , Pignolo Robert J. , Baujat Geneviève , Brown Matthew A , De Cunto Carmen , Di Rocco Maja , Hsiao Edward C. , Keen Richard , Le Quan Sang Kim-Hanh , Strahs Andrew , Marino Rose , Kaplan Frederick S

Background: FOP is an ultra-rare, severely disabling genetic disorder characterised by cumulative heterotopic ossification (HO), often preceded by episodic flare-ups, leading to physical disability and early death. Initial misdiagnosis can occur in ~90% of individuals leading to unnecessary, often harmful interventions. FOP is diagnosed and managed by multiple specialists, including endocrinologists.Objective: A prospective, 36-month, global natural...

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ea0070aep1020 | Hot topics (including COVID-19) | ECE2020

Elastographic techniques in localizing parathyroid adenomas

Cotoi Laura , amzar daniela-georgiana , Andreea Borlea , Cepeha Cristina , Dana Stoian

Introduction: Primary hyperparathyroidism (PHPT) is the third most frequent endocrinopathy, after type 2 diabetes mellitus and thyroid disease. It is most commonly caused by an overactive parathyroid gland resulting in high serum parathormone (PTH) concentrations and consequent high serum calcium concentrations. PHPT is nowadays commonly asymptomatic, with high prevalence among postmenopausal women (female – male ration 3–4:1).Materials and m...

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ea0070aep1021 | Hot topics (including COVID-19) | ECE2020

Association of osteoprotegerin 1181G > C and 245T > G polymorphisms and diabetic Charcot osteoarthropathy in Egyptian patients

Zakaria Basma , Gawish Hanan , Elfarahaty Reham , Tarshoby Manal

Aim: Egypt is among the world’s top 10 countries in terms of the highest number of people with diabetes. Charcot foot is a serious complication that affect bones, joints, and soft tissues of the foot or ankle. Although the etiology is linked to different inflammatory markers, yet not clear. Recently, an association between two polymorphisms (1181G > C and 245T > G) of the osteoprotegerin (OPG) gene and Charcot was suggested. The aim of this study was to explore p...

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ea0070aep1022 | Hot topics (including COVID-19) | ECE2020

miRNAs regulating BDNF and BDNFas in adipose tissue: Potential link between obesity and mood disorders

Lhamyani Said , Clemente Mercedes , Gentile Adriana , Chacón Pedro , Javier Pavón Francisco , José Tinahones Francisco , Olveira Gabriel , El Bekay Rajaa

Background and aim: Obesity (Ob) is tightly associated with metabolic diseases such as type 2 diabetes (DT2) andinsulin resistance (IR). Furthermore, obesity has been identified as one of the primary causes of mood disorders (MDs) including depression. Several studies have demonstrated the link between Ob, adiposity, neuroinflammation and MDs. The Brain-Derived Neurotrophic Factor (BDNF) and its regulator, the non-coding RNA BDNF antisense RNA (BDNFas), play an import...

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ea0070aep1023 | Hot topics (including COVID-19) | ECE2020

Vitamin D status and its associations with clinical and laboratory parameters in patients with Addison’s disease

Zawadzka Karolina , Matwiej Katarzyna , Sokołowski Grzegorz , Trofimiuk-Müldner Małgorzata , Skalniak Anna , Hubalewska-Dydejczyk Alicja

Introduction: The autoimmune process is currently the most common cause ofthe primary adrenal insufficiency cases in developed countries. The complexity of this process consists of genetic, immunological and environmental factors. It has been proven that vitamin D (VD) inhibits the production of inflammatory cytokines and can modulate immune-regulatory mechanisms.Purpose: The aim of our study was to evaluate the prevalence of VD insufficiencyin...

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ea0070aep1024 | Hot topics (including COVID-19) | ECE2020

Severe hypercalcemia in infants, a report of three cases

Kebaili Raoudha , Nesrine Jaballah , Tilouche Samia , Boughamoura Lamia

Introduction: Hypercalcemia in newborns and infants is often iatrogenic. Clinical signs are correlated with the degree of hypercalcemia and can lead to sever complications through dehydration, neurological disorders, convulsions and cardiac rythm disorders. The objective of our work is to study the clinical, biological, etiological and therapeutic aspects of hypercalcemia in infants.Material and Methods: Retrospective study on 3 patients hospitalized in ...

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ea0070aep1025 | Hot topics (including COVID-19) | ECE2020

Medications used by individuals with fibrodysplasia ossificans progressiva (FOP): Data from a global natural history study

C. Hsiao Edward , Al Mukaddam Mona , Baujat Geneviève , De Cunto Carmen , Keen Richard , J Pignolo Robert , Harnett Kathleen , Marino Rose , Kaplan Frederick S

Background: FOP is an ultra-rare genetic disorder characterised by episodic progressive heterotopic ossification (HO) and flare-ups, causing cumulative disability and early death. FOP is diagnosed and managed by multiple specialists, including endocrinologists. There are no established disease-modifying therapies to prevent HO in FOP. Treatment guidelines for symptomatic relief of FOP have recently been published by the International Clinical Council on FOP (ICC).1<...

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ea0070aep1026 | Hot topics (including COVID-19) | ECE2020

Anthropometric, metabolic and immunological parameters in children with type 1 diabetes mellitus and coexisting autoimmune disorders

Volkova Natalia , Solntsava Anzhalika

Objective: to assess the effects of associated autoimmune diseases on diabetes control, growth, lipid profile in children with type 1 diabetes mellitus (T1DM) and to determine the most predictive genetic, immune and metabolic risk factors of polyglandular autoimmunity in children with T1DM.Material and Methods: 89 children with combined autoimmune pathology (main group, age 11.82 ± 3.68 years) and 100 patients with isolated T1DM (control group, age ...

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ea0070aep1027 | Hot topics (including COVID-19) | ECE2020

Utilising internet of things and artificial intelligence to enable twin precision treatment for reversal of type 2 Diabetes

Shamanna Paramesh , Damodharan Suresh , Saboo Banshi , Chawla Rajeev , Mohammed Jahangir , Mohamed Maluk , Thajudeen Mohamad

Introduction: We evaluated Twin Precision Treatment (TPT) approach, a cluster of Internet of Things (IoT) and Artificial Intelligence (AI), validated biosensors and Continuous Glucose Monitoring (CGM) through Ambulatory Glucose Profile (AGP) integrated with machine learning algorithms, enabling physicians to empower patients to reverse diabetes.Methods: 64 T2DM (19 males, 45 female), registered on Twin Health TM service, managed by standard care of appro...

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ea0070aep1028 | Hot topics (including COVID-19) | ECE2020

A call for cardiologists and diabetologists to embrace neurological investigation for diabetic neuropathy in cardiovascular risk stratification

Tesic Dragan , Andric Dragica , Mitrovic Milena , Vukovic Bojan , Tomic Mirjana

Background: In the 2019 ESC Guidelines on diabetes, pre-diabetes and cardiovascular diseases, only retinopathy appears as a target organ damage as a parameter for stratification patients into very high-risk group. The aim of study was to check the strength of association between DN and isolated DR groups with cardiovascular complications.Methods: Chronic kidney disease (CKD) was defined by eGFR ≤ 59 ml/min/1.73 m2 and proteinuria (P...

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ea0070aep1029 | Hot topics (including COVID-19) | ECE2020

EndogenousInterleukin production by the skin cells (keratinocytes and fibroblasts) cocultured with mononuclears of patients with type 2 diabetes mellitusand type 2 diabetes with chronic foot ulcers in a 3D culture model

Mashkova Maryia , Mokhort Tatsiana , Goranov Vitaly

Our research focused on the role of immune mechanisms in diabetic foot ulcers development and impaired healing. The AIM of this study was to evaluate endogenous interleukin (IL1,4,6,8) production to the culture medium by the skin cells (keratinocytes and fibroblasts) cocultured with mononuclears of patients with type 2 diabetes mellitus (T2DM) and T2DM with chronic foot ulcers (DFU) in a 3D culture model.Materials and methods: A multilayer 3D immunocompe...

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ea0070aep1030 | Hot topics (including COVID-19) | ECE2020

Variants of hyperlipidemia in obese children are gender and insulin resistance dependent

Chaychenko Tetyana , Kharkova Mariia , Rybka Olena

Background: Insulin resistance and dyslipidemia inobese subjectsare important for predicting future cardiovascular risk. Purpose of the study was to analyze the lipid profile of obese children depending on gender and insulin resistance status.Subjects and methods: 247 overweight and obese children (160 boys and 87 girls) aged 2 to 18 y.o. were examined in the pediatric endocrinology department. Lipids assessment included measurement of total cholest...

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ea0070aep1031 | Hot topics (including COVID-19) | ECE2020

Type 2 diabetics with high risk of foot amputation: Role of sodium-glucose co-transporter inhibitors

Serrano Laguna Mª del Carmen , León Utrero Sara , Hayón Ponce María , Redondo Torres Enrique , José López Ibarra Pablo

Introduction: The use of iSGLT2 continues to be controversial in diabetic patients with peripheral arterial disease.Objectives: Assess the metabolic effect and the risk of amputations of iSGLT2 in diabetic patients cared for in the Multidisciplinary Diabetic Foot Unit (MDFU) compared to a control group.Material and Methods: A retrospective observational study where patients attended at the MDFU from December 2017 to January 2020 we...

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ea0070aep1032 | Hot topics (including COVID-19) | ECE2020

Association between variants in clock genes and type 2 diabetes in an elderly greek population

Tsekmekidou Xanthippi , Tsetsos Fotis , Koufakis Theocharis , Grammatiki Maria , Georgitsi Marianthi , Roumeliotis Athanasios , Panagoutsos Stylianos , Thodis Elias , Theodoridis Marios , Papanas Nikolaos , Papazoglou Dimitrios , Pasadakis Ploumis , Paschou Peristera , Zebekakis Pantelis , Kotsa Kalliopi

Background: Recent data suggest that disturbances in circadian clock functioning are implicated in the pathogenesis of type 2 diabetes (T2D), through alterations in plasma glucose levels, insulin secretion and sensitivity, energy intake, and genomic expression in liver and pancreas. This study aimed to assess a potential association between variants in clock genes and T2D risk in a population of Greek elderly people.Methods: In a case-control design, 125...

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ea0070aep1033 | Hot topics (including COVID-19) | ECE2020

Prolonged Metformin intake is associated with decreased thyroid nodular growth in obese

Lushchyk Maxim , Grigorovich Artur , Tuzava Hanna , Ameliyanovich Maxim , Mosse Irma , Drozd Valentina , Danilova Larissa I

Obesity and weight excess is a widespread condition all over the world, as well as thyroid nodular disease. Screening studies in different populations prove a higher frequency of nodular thyroid formations of various nature in overweight individuals.Aim: In our study, we evaluated the dynamics of the volume of dominant and non-dominant nodular formations, as well as their sonographic structure in overweight patients with prediabetes in the groups with tw...

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ea0070aep1034 | Hot topics (including COVID-19) | ECE2020

Characterization of dyslipidaemia and association of lipoprotein(A) plasma levels with metabolic control in young adults with type 1 diabetes

Inácio Isabel , Ferrreira Sara , Rosinha Patrícia , Azevedo Teresa , Alves Márcia , Dantas Rosa , Balsa Ana Margarida , Guimarães Joana

Introduction: The 2019 European Society of Cardiology/European Atherosclerosis Society lipid guidelines changed the cardiovascular risk categories and LDL-C goals, and suggests that lipoprotein(a) [Lp(a)] measurement should be considered at least once in adult person’s lifetime. Although young people with type 1 diabetes (T1DM) without major cardiovascular risk factors (CVRF) were previously considered to be at low or moderate risk, they are at least at moderate risk bas...

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ea0070aep1035 | Hot topics (including COVID-19) | ECE2020

Polygenic risk scorecaptures 11% of of type 2 diabetes variability in latvian population

Pečulis Raitis , Reščenko Raimonds , Pīrāgs Valdis , Konrāde Ilze , Kloviņš Jānis

Type 2 diabetes (T2D) is a multi factorial disease with increased prevalence globally. The risk of developing T2D is determined by the interaction of genetic and environmental factors. Over the decades of research, hundreds of T2D genetic susceptibility markers (mostly single nucleotide polymorphisms or SNP) have been discovered. Yet generally their contribution to increased T2D risk is small and have negligible value in clinical practice to aid T2D treatment, categorize patie...

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ea0070aep1036 | Hot topics (including COVID-19) | ECE2020

Insights on ghrelin immunohistochemistry: Variations between intrinsic molecular subtypes of breast cancers

Armasu Ioana , Ciobanu-Apostol Delia-Gabriela , Ianole Victor , Preda Cristina , Vasiliu Ioana , Stana Bogdan , Alexandru Pohaci-Antonesei Catalin , Mihaela Barbu Roxana , Bild Walther , Lacramioara Serban Ionela

Introduction: Ghrelin, a peptide hormone produced in the stomach, stimulates secretion of growth hormone and regulates appetite and energy homeostasis. Various other effects attributed to ghrelin may contribute to many aspects of cancer development and progression.Material and Methods: Using polyclonal antibody immunohistochemistry, we assessed (by intensity scoring) the immunolocalization of ghrelin in 70 tissue samples, and described particularities wi...

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ea0070aep1037 | Hot topics (including COVID-19) | ECE2020

Management of glucose profile throughout strict COVID-19 lockdown by patients with type 1 Diabetes prone to hypoglycemia using sensor-augmented pump

Viñals Clara , Mesa Alex , Roca Daria , Vidal Mercè , Pueyo Irene , Conget Ignacio , Giménez Marga

Aims: Spain has been one of the worst affected countries by the COVID-19 pandemic. A very strict lockdown at home was imposed with a tough restriction of mobility. We aimed to evaluate the impact of this exceptional scenario on glucose profile of patients with type 1 diabetes (T1D) prone to hypoglycemia using sensor-augmented pump (SAP).Methods: Patients with T1D prone to hypoglycemia using SAP (640G Medtronic Minimed) for at least 6 months under the fun...

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ea0070aep1038 | Hot topics (including COVID-19) | ECE2020

Gestational diabetes as unusual presentation of maternally inherited diabetes and deafness (MIDD)

Akbar Ali Uzair , Sajjad Sadiq Muhammad , Ann Brosnan Dr. Elizabeth , Aamir Shahzad Muhammad

Maternally inherited diabetes and deafness (MIDD) is rare subtype and monogenic form of adult onset diabetes caused from point mutation at position 3243 of mitochondrial DNA. The name indicates the main features of disease including diabetes and sensorineural hearing loss. About one percent of people with diabetes can have MIDD but the diagnosis can be challenging and needs high clinical suspicion on basis of family history, clinical features of diabetes, deafness and unusual ...

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ea0070aep1039 | Hot topics (including COVID-19) | ECE2020

Impact of obesity on types of myocardial infarction

Gin Julian , Wilson Andrew

Introduction: Obesity is an independent risk factor of coronary artery disease, and it has also been shown to be associated with increased survival in some instances such as myocardial infarction – dubbed the ‘Obesity Paradox’. However, there is a paucity of studies identifying the type of myocardial infarction – non-ST-segment elevation MI (NSTEMI) or ST-segment MI (STEMI) – that may be differentially prevalant according to BMI (body mass index) ...

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ea0070aep1040 | Hot topics (including COVID-19) | ECE2020

Differences in health-related quality of life between type 1 and type 2 diabetic patients in Austria

Al-taie Nawras , Stingl Harald , Maftei Delia

Background and aim: Improving the quality of life is one of the main goals of treating diabetic patients in addition to manage glycaemic control and diabetes complications. The study aim was to assess and compare the quality of life among Austrian patients with type 1 and type 2 diabetes mellitus using the German version of the World Health Organization Quality of Life-BREF instrument (WHOQOL-BREF).Methods and Materials: This was an observational study t...

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ea0070aep1041 | Hot topics (including COVID-19) | ECE2020

Assessment of association between VDR variants and type 2 diabetes in an elderly greek population

Tsekmekidou Xanthippi , Tsetsos Fotis , Koufakis Theocharis , Grammatiki Maria , Georgitsi Marianthi , Roumeliotis Athanasios , Panagoutsos Stylianos , Thodis Elias , Theodoridis Marios , Papanas Nikolaos , Papazoglou Dimitrios , Pasadakis Ploumis , Paschou Peristera , Zebekakis Pantelis , Kotsa Kalliopi

Background: Vitamin D receptor (VDR) in the presence of active calcitriol (1.25--dihydroxy vitamin D) acts as a transcription factor that modulates the gene expression oftransport proteins, which are involved in calcium metabolism. Accumulating evidence suggest apotential implication of vitamin D deficiency in the pathogenesis of diabetes mellitus. We aimed toassess whether variants in the VDR gene contribute to risk of Type 2 Diabetes Mellitus (T2DM).<p class="ab...

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ea0070aep1042 | Hot topics (including COVID-19) | ECE2020

A case of intentional overdose of insulin glargine and lispro treated with hydrocortisone

Boddhula Sowmya , Tam Matthew , Falciglia Mercedes

Introduction: Patients with diabetes have nearly twice the risk of depression compared to general population. Prolonged hypoglycemia can occur with insulin overdose and treatment involves correction of hypoglycemia with oral or intravenous glucose supplementation, with glucagon or octreotide in some cases. Glucocorticoids are not routinely administered but can be used as an adjunct in severe cases. We present a case of intentional insulin overdose in a young diabetic patient w...

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ea0070aep1043 | Hot topics (including COVID-19) | ECE2020

Trabecular bone score and insulin resistance in type 2 diabetes mellitus

Hayon Ponce Maria , Serrano Laguna Mª del Carmen , Aviles Perez Maria Dolores , Fontana Beatriz Garcia , Salvatierra Sheila Gonzalez , Becerra García Diego , Muñoz Torres Manuel

Introduction: Trabecular Bone Score (TBS) is a new non-invasive method to evaluate trabecular bone quality at the lumbar spine. The literature has contradictory results concerning the influence of insulin resistance and adipose tissue on bone, for this reason it is of interest to evaluate factors that determine bone health and risk of fracture in patients with T2DM.Objective: To analyze the relationship between insulin resistance and adipose tissue with ...

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ea0070aep1044 | Hot topics (including COVID-19) | ECE2020

Incidence of large-for-gestational age newborns is still elevated in women with type 1 diabetes in good glycaemic control

de Valk Harold W. , Lisa A Oosterwijk

Introduction: Glycemic control has a major effect on fetal growth in women with type 1 diabetes mellitus (DM1), worse control leading to increased growth (large for gestational age (LGA) or very large for gestational age (VLGA) fetus). Current guidelines promote strict control (HbA1c ≤ 48 mmol/mol) before and during pregnancy. Continuous glucose monitoring (CGM) has been instrumental in achieving this goal. We performed a retrospective chart review of pregnancy outcomes ...

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ea0070aep1045 | Hot topics (including COVID-19) | ECE2020

Abstract unavailable...

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ea0070aep1046 | Hot topics (including COVID-19) | ECE2020

The association of glomerular filtration rate with coronary artery disease in type 2 diabetic patients

Kazemijahromi Mitra , Samimagham HamidReza , Farshidi Hossein , Nikparvar Marzieh , Arabi Mohsen

Background and aim: Chronic Kidney Disease and Diabetes Mellitus can influenceCoronary Artery Disease (CAD) independently. The aim of this study was to evaluate the association of Glomerular Filtration Rate (GFR) and Coronary Artery Disease in type 2 diabetic patients. (T2DM)Methods: This cross sectional study evaluated 362 T2DM patients with clinical presentation of CAD whose documents were registered in angiography center during 18 months. GFR was meas...

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ea0070aep1047 | Hot topics (including COVID-19) | ECE2020

Prediction of weight loss response to liraglutide

Mosikian Anna , Alekseenko Tatiana , Martjanova Maria , Babenko Alina

Background: Obesity is a significant risk factor for type 2 diabetes mellitus (T2D), hypertension and ischemic heart disease development. Moreover, in patients with already diagnosed T2D, obesity puts a crimp in achievement of glycemic target. Thus, body weight reduction is important both to prevent T2D and to treat it successfully. However lifestyle habits, diet and physical activity are the key factors of T2D prevention and treatment, eating disorders and disturbed appetite ...

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ea0070aep1048 | Hot topics (including COVID-19) | ECE2020

Diabetes and COVID-19

Miguel Peteiro Miranda Carlos , Jorge Ortez Toro Jose , Sanz Martín Borja , Román Gimeno Sergio , Urdaiz Borque Rosana , Tabuenca Ana Agudo , Gimeno Orna Jose Antonio

Background: Although obesity and has been associated with COVID-19 mortality, the absolute and relative risks for Type 2 diabetes (DM2) is unknown. The aim of this study was to analyse metabolic characteristics of patients infected by COVID-19 hospitalised and evaluate whether DM2 have an impact in this group of patients.Methods: We retrospectively analysed data of COVID-19 patients hospitalized to a large academic hospital system in Zaragoza between Mar...

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ea0070aep1049 | Hot topics (including COVID-19) | ECE2020

Diabetic emergencies during COVID-19 –A multi-centre experience

Qamar Sulmaaz , Aziz Umaira , Nasir Sadia , Armeni Eleni , Zosmer Maya , Joseph Tobin , Crawley Eleanor , Tutty Susan , Lynch Jo , Bouloux Pierre , Yousseif Ahmed , Khan Sidrah , Menon Ravi , Nethaji Chidambaram , Karra Efthimia

Introduction: Diabetes mellitus is as a major contributor to disease severity and mortality in patients with Covid-19 infection, as the estimated increase in risk of death in hospitalised patients is 3.5-times (for T1DM) and 2.03-times (for T2DM).This retrospective analysis recruited 35 patients from three London hospitals who presented with diabetic emergencies i.e. diabetic ketoacidosis (DKA), Hyperglycaemic hyperosmolar state( HHS), presence of ketone...

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ea0070aep1050 | Hot topics (including COVID-19) | ECE2020

The impact of strict COVID-19 lockdown in spain on glycemic profiles in patients with type 1 Diabetes prone to hypoglycemia using standalone continuous glucose monitoring

Mesa Alex , Viñals Clara , Pueyo Irene , Roca Daria , Vidal Mercè , Giménez Marga , Conget Ignacio

Aims: Spain has been one of the worst affected countries by the COVID-19 pandemic. A very strict lockdown at home was imposed with a tough restriction of mobility. We aimed to evaluate the impact of this exceptional scenario on glucose profile of patients with type 1 diabetes (T1D) prone to hypoglycemia using standalone continuous glucose monitoring.Methods: Patients with T1D prone to hypoglycemia using multiple daily injections and either a Dexcom G5 or...

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ea0070aep1051 | Hot topics (including COVID-19) | ECE2020

Clinical characteristics and outcomes of COVID-19 hospitalized patients with diabetes in the United Kingdom: A retrospective single centre study

Alkundi Alamin , Mahmoud Ibrahim , Musa Abdelmajid , Naveed Saima , Alshawwaf Mohammed

Aim: To describe the clinical characteristics and outcomes of hospitalized COVID-19 patients with diabetes.Methods: A retrospective cross-sectional study was conducted among patients admitted to the William. Harvey Hospital in England between March 10th and May10th, 2020 with a laboratory confirmed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), known as COVID19. Variation in characteristics, length of stay in hospital, diabetes status, dur...

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ea0070aep1052 | Hot topics (including COVID-19) | ECE2020

Characteristics and outcomes in COVID –19 with Type 2 diabetes as compared with patients without diabetes – Retrospective single center cohort study

Gosavi Rajesh , Mitra Sajal , Aher Archana , Holay Madhuri , Patil Somraj , Assudani Deepanshu

Introduction: COVID 19 is now a global pandemic. Diabetes is postulated to be a risk factor for mortality due to COVID –19Methods: We retrospectively evaluated the inpatient medical record data, of patients admitted over last two months in a public hospital in Central India to compare the attributes of mortality in patients without T2DM and with T2DM including their glycemic clinical characteristics. Unpaired t – test and Fisher’s exact...

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ea0070aep1053 | Hot topics (including COVID-19) | ECE2020

Case of steroid diabetes in a female with the hemophagocytic syndrome and panniculitis of Weber-Kristen

Antonyuk Olena

39-year old female reported usage of methylprednisolone (20–80 mg daily) for three months since the last decade of January 2020. She received methylprednisolone for controlling of panniculitis of Weber-Kristen (diagnosis was proved twice histologically in Ukraine and Austria. Before starting steroid therapy, there was no glucose impairment in her history. The patient has different complaints, including fatigue, increased body temperature, hypersensitivity of the skin, vo...

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ea0070aep1054 | Hot topics (including COVID-19) | ECE2020

A pilot trial for silymarin in prediabetic patients with preclinical liver disease: Focus on insulin resistance

Javier Martinez-Martin Francisco , Kuzior Agnieszka , Maria Fernandez-Trujillo-Comenge Paula , Hernandez-Lazaro Alba , Quintana-Arroyo Sara , Arnas-Leon Claudia , Acosta-Calero Carmen , Gonzalez Díaz Paula , Perdomo-Herrera Esperanza , Lucía Tocino-Hernandez Alba

Introduction: Silymarin is a standardized extract of the milk thistle (Sylibum marianum) seeds, containing a mixture of flavonolignans: silybinin, isosilybinin, silycristin, silydianin, and others. It is used in the treatment of toxic liver damage and as adjunctive therapy in chronic hepatitis and cirrhosis. Recent studies have shown a potential benefit in the treatment of diabetes mellitus and non-alcoholic fatty liver disease. We undertook to study the effect of silymarin on...

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ea0070aep1055 | Hot topics (including COVID-19) | ECE2020

The effects of selective activation of kisspeptin neurons in hypothalamic arcuate nucleus on energy metabolism in mice

Li Qian , Liu Qinyu , Huang Guifeng , Lin Wei , Chen Gang , Wen Junping

Objectives: This study aims to determine which metabolic tissue is involved in the process of kisspeptin neurons regulate energy metabolism so that it may provide a novel therapy for metabolic related diseases such as obesity.Methods: Kiss1-CreGFP mice were used in this study. And we selectively activated kisspeptin neurons by using Designer-receptors-exclusively-activated-by-designer-drugs (DREADDs) technology. Mice were bilaterally injected with the Cr...

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ea0070aep1056 | Hot topics (including COVID-19) | ECE2020

Levels of lymphocytes subpopulations in peripheral blood among patients with diabetes mellitus type 2

Ganeva Silviya , Todorova Katya , Lukanov Tsvetan , Rayanova Ginka , Bajeva Svetla

Aim of the study was to investigate the lymphocytes (lymph) subpopulations as a part of immune response in peripheral blood among the patients with Diabetes mellitus type 2 (DMT2).Patients and methods: A prospective, cross-sectional, comparative, ‘case-control’ study was conducted among 70 patients with DMT2. The levels of lymph subtypes[-general nonspecific T-lymph (CD3+); T-helper lymph (CD4+); T--cytotoxic lymph (CD8+), natural...

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ea0070aep1057 | Hot topics (including COVID-19) | ECE2020

Role of insulin aspart fiasp in patients with diabetes mellitus

León Utrero Sara , Serrano Laguna M del Carmen , Redondo Torres Enrique , Piedrola Maroto Gonzalo , Quesada Charneco Miguel

Introduction: Postprandial glycemic control is complex as well as insufficient. Its impact on global metabolic control (HbA1c) is controversial with various works that support its influence in terms of glycemic variability and genesis of micro and/or macrovascular complications. Fiasp due to its special formulation allows a more effective control of postprandial glycemia being an interesting alternative to the rapid-acting insulin analogavailable.Objecti...

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ea0070aep1058 | Hot topics (including COVID-19) | ECE2020

Changes in metabolic control and body composition with Semaglutide sc in patients with type 2 diabetes mellitus

Redondo Enrique , Serrano Mª Carmen , Leon Sara , Andreo Mª Carmen , Sebastian Luisa , Quesada Miguel , Lopez-Ibarra Pablo

Objectives: aGLP1 have been positioned as an effective and safe treatment in patients with Type 2 Diabetes Mellitus (DM2). The objective was to evaluate the changes metabolic and body composition at 6 months after initiation with Semaglutide weekly subcutaneous added to its basic treatment in patients with DM2.Material and Methods: Prospective observational study. Treatment was started in 42 patients with DM2, with weekly subcutaneous Semaglutide with a ...

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ea0070aep1059 | Hot topics (including COVID-19) | ECE2020

Coronary heart disease and diabetes mellitus type II in emergency workers of the Chernobyl accident

Belyi David , Nastina Olena , Gabulavichene Zhanna , Sidorenko Gennedyi , Kursina Nataly , Bazyka Olexander

Objective: The study was focused on evaluation of coronary heart disease (CHD) and diabetes mellitus type II (DM) onset in emergency workers (EW) who took part in elimination of the Chornobyl accident in 1986 year.Materials and methods: The EW (n = 443, males) and 172 males not exposed to ionizing radiation (the control group, CG) were involved in the study in 2013–2019. EW absorbed doses of irradiation changed from 4.3 till 710 cGy. D...

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ea0070aep1060 | Hot topics (including COVID-19) | ECE2020

Risk factors for foot ulceration among adult patients with diabetes on chronic hemodialysis in Dakahlia governorate, egypt

Al-Nakeeb Ahmed , State Omnia , Tarshoby Manal , Kyrillos Fady

Background: Although risk factors for diabetic foot ulceration (DFU) have been extensively studied in patients with diabetes in Egypt, there is surprisingly limited evidence among those on chronic hemodialysis (CHD).Aims: To investigate the risk factors for foot ulceration in adult patients with diabetes with end stage renal disease on hemodialysis in Dakahlia Governorate central hemodialysis units.Patients and methods: This Cross-...

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ea0070aep1061 | Hot topics (including COVID-19) | ECE2020

The first case report of Pembrolizumab inducing thyroiditis and hypophysitis

Abdel Rahman Maraqa Sima , McMahon Robert , Pinjala Anusha , Arce Gastelum Alheli , Zena Mohsen

Pembrolizumab is a monoclonal antibody (ab) that exerts antineoplastic effects by inhibiting the immunoevasive effects PD-1 grants cancer cells. It’s used to treat several forms of cancer, including melanoma and non-small cell lung cancer. Despite the promise pembrolizumab has demonstrated, it has been associated with immune-related adverse events. In this report, we describe the first case of both thyroiditis and hypophysitis occurring during active pembrolizumab t...

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ea0070aep1062 | Hot topics (including COVID-19) | ECE2020

The emotional outbreak of (endocrine) cancer patients during COVID-19 pandemic

Falcone Rosa , Grani Giorgio , Ramundo Valeria , Melcarne Rossella , Giacomelli Laura , Filetti Sebastiano , Durante Cosimo

Background: The 2019 coronavirus disease (COVID-19) pandemic is a public health emergency and raises the issue of psychological and physical resilience in more vulnerable patients. We investigated the emotional impact of the SARS-CoV-2 spread among cancer patients, followed at our Institution in Italy, after the restrictive measures imposed by the government and the disruption of planned clinical activities.Methods: From March 18th to April 1st, 2020, we...

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ea0070aep1063 | Hot topics (including COVID-19) | ECE2020

Neuromyelitis optica presenting as intractable hiccoughs and SIADH: A Case Report

Qamar Sulmaaz , Armeni Eleni , Mainuddin Md , Hotton Gary , Menon Ravi

Neuromyelitis Optica (NMO) is a neuro-inflammatory condition usually presenting with optic nerve and spinal cord events, caused by autoimmunity to Aquaporin 4 (AQ4) channels in the central nervous system (CNS). The high density of AQ4 channels in the hypothalamus and area postrema mean that NMO can occasionally present with atypical features. We present a 56-year old South Asian man, who presented with hiccoughs and Syndrome of inappropriate antidiuretic hormone (SIADH ) and w...

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ea0070aep1064 | Hot topics (including COVID-19) | ECE2020

Pharmacokinetics and pharmacodynamics of macimorelin acetate (AEZS-130) in paediatric patients with suspected growth hormone deficiency (GHD)

Csákváry Violetta , Muzsnai Agota , Raduk Dmitri , Chaychenko Tetyana , Bentz Damholt Birgitte , Bakhtadze Bagci Ekaterine , Teifel Michael , Ammer Nicola

Growth hormone deficiency (GHD) in children is a rare, aetiologically diverse condition that results in growth failure and short stature. Inadequate response to two different growth hormone stimulation tests (GHST) is required for the diagnosis of GHD. Macimorelin acetate, a potent, orally administered growth hormone (GH) secretagogue, is approved by the FDA and EMA for the diagnosis of adult GHD. Study AEZS-130-P01 is the first of two studies to investigate macimorelin acetat...

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ea0070aep1065 | Hot topics (including COVID-19) | ECE2020

Efficacy and safety of long-acting pasireotide in acromegalic patients in the real life: The reappraisal of the first-dose follow-up visit

Urbani Claudio , Dassie Francesca , Zampetti Benedetta , Maria Di Certo Agostino , Cozzi Renato , Maffei Pietro , Bogazzi Fausto

Background: Pasireotide is a multi-ligand somatostatin analogue licensed in a long-acting release formulation (PAS-LAR) for the treatment of acromegaly. The real-life reports with PAS-LAR are still scanty.Objectives: To assess the efficacy and safety of PAS-LAR in patients with acromegaly.Patients and methods: Prospective observational multi-centre study enrolling acromegalics evaluated before (baseline) and 1, 6, 12, 24, and 36 mo...

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ea0070aep1066 | Hot topics (including COVID-19) | ECE2020

Effect of long term rhgh treatment on bone mineral density in patients with childhood onset growth hormone deficiency

Dassie Francesca , Spinazze Alice , Russo Lucia , Parolin Matteo , Mioni Roberto , Maffei Pietro , Zaccaria Marco , Vettor Roberto , De Carlo Eugenio

Background: RhGH treatment in adults with childhood onset growth hormone deficiency (COGHD) affect bone metabolism over time according to gender and age. A long-term study of bone mass density (BMD) in young-middle age hypopituitary patients with COGHD may better highlight possible benefits of therapy and improve clinical follow up.Methods: We enrolled 40 adults (age range during follow-up: 16.8–36 years, F: 38%) with COGHD with at least 20 years o...

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ea0070aep1067 | Hot topics (including COVID-19) | ECE2020

Androgen deprivation therapy for prostate cancer with GnRH agonists: Metabolic consequences

Gritskevich Elena , Demidova Tatyana

Objective: To assess metabolic disorders and thyroid function in patients with prostate cancer, who were treated with gonadotropin-releasing hormone(GnRH) agonist. Study design follow-up study.Materials and methods: 102 patients were enrolled to the study, 99 subjects were followed up till the study completion. The mean age was 69 years old (95% confidence range: 61.5–79.2 years old). To assess thyroid function, thyroid-stimulating hormone (TSH) an...

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ea0070aep1068 | Hot topics (including COVID-19) | ECE2020

Abstract unavailable...

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ea0070aep1069 | Hot topics (including COVID-19) | ECE2020

The role of growth hormone device optimisation in patient-reported outcomes: Real-world evidence from South Korea

Lee Ji-Eun , Lee Kee-Hyoung , Park Mi Jung , Yang Seung , Young Kim Eun , Rhie Young-Jun , Jung Min-Ho , Yang Aram , Kim Shin-Hye , Yoojin Chung Lindsey , Young Ko Su , Ju Lee Young , Nedjatian Navid , Yeong Chung Woo

Growth hormone (GH) therapy (GHT) requires long-term commitment to daily sc GH injections that may present adherence challenges. Patient preference and adherence have been shown to be affected by delivery devices in association with convenience of administration, level of injection-site pain, confidence in correct dose administration and satisfaction with the device. This survey investigated if switching GH device – from NordiLet/others to NordiFlex – improved pati...

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ea0070aep1070 | Hot topics (including COVID-19) | ECE2020

Efficacy of lanreotide autogel for chinese patients with active acromegaly with or without prior pituitary surgery: A post hoc analysis of the Lantern study

An zhenmei , Lei Ting , Duan lian , Zhang Lihui , Zhou Su , Shi Xiaofeng , Feng Gu

Background: Previous studies have yielded conflicting results on biochemical control with medical therapy in patients with or without prior pituitary surgery. The LANTERN study (NCT02493517) demonstrated that lanreotide autogel (LAN ATG) was non-inferior to lanreotide prolonged release (LAN PR) in Chinese patients with active acromegaly. This post hoc analysis of the LANTERN study aimed to explore the efficacy of LAN ATG in patients with or without prior pituitary surgery....

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ea0070aep1071 | Hot topics (including COVID-19) | ECE2020

Outcomes of pituitary apoplexy: A comparison of microadenomas and macroadenomas

Nakhleh Afif , Sviri Gill , Shehadeh Naim , Assalia Naffaa Mai , Hochberg Irit

Introduction: Apoplexy of pituitary microadenomas is rare and not well documented in the literature. We aimed to assess the clinical characteristics of apoplexy of pituitary microadenomas compared to that of macroadenomas.Design: A single-center retrospective longitudinal cohort study.Methods: We retrieved clinical records of patients over 18 years old, hospitalized in Rambam hospital (Haifa, Israel) between 1.1.2001–31.10.20...

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ea0070aep1072 | Hot topics (including COVID-19) | ECE2020

Pregnancy outcomes in acromegaly: A single tertiary center case series

Gonul Iremli Burcin , Hanife Oguz Seda , Firlatan Busra , Dagdelen Selcuk , Erbas Tomris

Introduction: Pregnancy occurs relatively rare women with acromegaly. However, in recent years, pregnancy has become more likely to occur in acromegalic women possibly due to improvements in acromegaly treatment, and advanced assisted reproduction techniques.Methods: In this case series, we retrospectively analyzed 11 pregnancies of 8 acromegalic women followed in the university hospital in a time range between 2009–2019. Data were obtained from pa...

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ea0070aep1073 | Hot topics (including COVID-19) | ECE2020

A randomized-controlled trial of tesomet resulted in significant weight loss in hypopituitary patients with hypothalamic obesity

Huynh Kim , Klose Marianne , Krogsgaard Kim , Drejer Jorgen , Byberg Sarah , Madsbad Sten , Magkos Faidon , Aharaz Abdellatif , Edsberg Berit , Astrup Arne , Feldt-Rasmussen Ulla

Background and objective: Hypothalamic obesity is characterized by rapid and severe weight-gain with increased risk of cardiovascular and metabolic disorders. Currently, there are no approved or effective pharmacological treatments and conventional weight management remain largely ineffective in hypothalamic obesity. This trial investigated safety and efficacy of Tesomet (0.5 mg tesofensine and 50 mg metoprolol) in hypopituitary patients with hypothalamic obesity.<p class=...

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ea0070aep1074 | Hot topics (including COVID-19) | ECE2020

ACROCOVID: An international survey on care for acromegaly during the COVID-19 era

Giustina Andrea , Mario Cesana Bruno , Marks Muriël , Mortini Pietro , Khawaja Sheila , Fleseriu Maria

The COVID-19 pandemic is significantly affecting the care of chronic conditions globally. Acromegaly is a rare chronic condition with a prevalence ranging between 2.8–13.7 cases/100.000 people. Acromegaly management requires a multidisciplinary team of health care professionals (HCPs), mainly including endocrinologists, neurosurgeons, and specialized endocrine nurses. Frequent consultations, particularly during early stages of the disease, and pre/post-surgery are necess...

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ea0070aep1075 | Hot topics (including COVID-19) | ECE2020

COVID-19 and hypopituitarism. Experience from an endocrine center in a high-impact area

loli Paola , Frara Stefano , Pasquali Riccardo , Di Filippo Luigi , Rovere Querini Patrizia , Giustina Andrea

SARS-CoV-2 has rapidly spread from China throughout the world leading to a pandemic. COVID-19 can be severe enough to cause hospitalization and death. Many patients with endocrine disorders share many of the recognized risk factors for severe disease and have potential additional risks due to corticosteroid replacement therapy or alteration in blood electrolytes. We here report three cases of COVID-19 in patients with post-surgical hypopituitarism and documented hypocortisolem...

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ea0070aep1076 | Hot topics (including COVID-19) | ECE2020

Outcome squares integrating efficacy and safety, as applied to functioning pituitary adenoma surgery

de Vries Friso , Lobatto Daniel , Verstegen Marco , Schutte Pieter , Notting Irene , Kruit Mark , Ahmed Fasial , Pereira Alberto M , van Furth Wouter , Biermasz Nienke

Background: Transsphenoidal surgery is standard care in the treatment of hormone-secreting pituitary adenomas. Current clinician-reported surgical outcome measures are one-dimensional, typically focussing primarily on complete or partial resection and secondarily on complication rates. However, outcomes are best reflected by the delicate balance of efficacy and complications at patient level. This study proposes a novel way to classify outcome, integrating efficacy and safety ...

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ea0070aep1077 | Hot topics (including COVID-19) | ECE2020

Pituitary apoplexy in the elderly: About 3 cases

Drissi Oudghiri Meryem , Motaib Imane , Elamari Saloua , Chadli Asmaa

Introduction: Pituitary apoplexy is a rare clinical syndrome related to abrupt hemorrhage and/or infarction of the pituitary gland,usually occurring in patients with pre-existing pituitary disease. it is an endocrine emergency requiring rapid diagnosis and appropriate management.Observation: We report the observation of three patients.Case 1: This is a 72 year old patient, without any particular pathological history, who presented ...

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ea0070aep1078 | Hot topics (including COVID-19) | ECE2020

First results of a desmopressin test in forecasting of relapse acth-dependent cushing syndrome undergoing tss

Mirsaidova Umida A , Halimova Zamira

Hypercorticism is a syndrome caused by extended and very high exposure of glucocorticoids to the body. ACTH-dependent Cushing’s syndrome develops as a result of the overproduction of adrenocorticotropic hormone by the pituitary adenoma. The main treatment for ACTH-dependent Cushing’s is transnasal transsphenoidal removal of the pituitary adenoma. A the same time, the recurrence rate of Cushing syndrome is observed up to 3% during the year and up to 3% –22% of...

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ea0070aep1079 | Hot topics (including COVID-19) | ECE2020

The histological structure of giant non functional pituitary adenomas with invasive growth

Yulduz Urmanova , Mirtukhtaeva Malika

Aim of the research – to study the histological structure of non functional pituitary giant adenomas (NFPA).Materials and methods: We observed 17 patients with giant NFPA, among them 5 male and 6 female, mean age 37.8. All patients were undergone surgical treatment by transsphenoidal access in Center of Endocrinology of MoH RU in neurosurgery department during 2019–2020 year. All patients were undergone the spectrum of analyses, including end...

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ea0070aep1080 | Hot topics (including COVID-19) | ECE2020

Gender differences of growth hormone and insulin-like growth factor-1 in patients with acromegaly after radiation therapy

Issaeva Saodat , Khalimova Zamira , Kholikova Adliya , Safarova Shokhsanam

Purpose of the study: To determine the gender differences in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in patients with somatotropic pituitary adenomas after radiation therapy (RT).Materials and research methods: The object of the study is 94 patients with acromegaly receiving RT in a total dose of 45–50 gray. Of these, 26 (27.7%) are men and 68 (72.3%) are women. The peak manifestation of acromegaly in the total sample was in th...

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ea0070aep1081 | Hot topics (including COVID-19) | ECE2020

Efficacy of lanreotide autogel in Chinese patients with acromegaly according to tumor size: A post hoc analysis of the LANTERN study

An Zhenmei , Lei Ting , Duan lian , Zhang Lihui , Zhou Su , Shi Xiaofeng , Feng Gu

Background: The LANTERN study (NCT02493517) has demonstrated that lanreotide autogel (LAN ATG) was non-inferior to lanreotide prolonged release (LAN PR) in Chinese patients with active acromegaly. This post hoc analysis of the LANTERN study assessed the impact of tumor size on treatment effect.Design: In the LANTERN study, LAN ATG was started at 90 mg and subsequently titrated according to GH and IGF-1 levels for 32 weeks. Tumor diameters > 10 mm wer...

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ea0070aep1082 | Hot topics (including COVID-19) | ECE2020

Somapacitan dose–IGF-I–response and impact of starting dose levels in adults with growth hormone deficiency – a model-based analysis

Juul Kildemoes Rasmus , Viig Overgaard Rune , Højby Rasmussen Michael

In patients with adult growth hormone deficiency (AGHD), the dose of growth hormone (GH) replacement is individualised based on clinical outcome, insulin-like growth factor-I (IGF-I) levels and adverse reactions. The aim of this analysis was to characterise dose–IGFI–response for somapacitan, a long-acting reversible albumin-binding GH derivative, and to derive expected IGF-I levels for various starting doses. Somapacitan dose–IGF-I–response analysis wa...

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ea0070aep1083 | Hot topics (including COVID-19) | ECE2020

Monitoring of weekly IGF-I levels during long-acting growth hormone therapy with somapacitan

Juul Kildemoes Rasmus , Højby Rasmussen Michael , Agersø Henrik , Viig Overgaard Rune

Somapacitan is a long-acting growth hormone (GH) derivative designed for once-weekly subcutaneous administration. Correct assessment of insulin-like growth factor-I (IGF-I) levels is essential during treatment of GH deficiency (GHD) and must account for fluctuations over a dosing interval. We evaluated whether reliable estimates of weekly mean and peak IGF-I could be obtained from a single IGF-I sample. A population pharmacokinetic/pharmacodynamic model was available from phar...

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ea0070aep1084 | Hot topics (including COVID-19) | ECE2020

Diagnostic of erdheim chester histiocytosis 9 years after!

Mezoued Mouna , B Benabes , Azzoug Said

Erdheim Chester disease (ECD) is a non langheransian rare histiocytosis, with around 500 cases described worldwide since its discovery for the first time in 1930 by Jakob Erdheim et William Chester. It is a multivisceral disease, characterized by a proliferation of abnormal histocytes CD68 positive and CD1a negative, including a retroperitoneal and perirenal fibrosis, a peri-aortitis, an osteosclerosis of the lower limbs and sometime an exophthalmia or an diabetes insipidus. H...

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ea0070aep1085 | Hot topics (including COVID-19) | ECE2020

The course and predictors of postoperative diabetes insipidus

Mikhaylova Darya , Dzeranova Larisa , Yu. Rebrova Olga , Pigarova Ekaterina , Rozhinskaya Ludmila , Grigoriev Andrey , Azizyan Vilen , Ivashenko Oksana

The course and predictors of postoperative diabetes insipidus.Objectives: To evaluate the course and predictors of permanent and transient postoperative diabetes insipidus (DI).Patients and Methods: The study included 152 patients undergoing endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40. 73 patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inacti...

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ea0070aep1086 | Hot topics (including COVID-19) | ECE2020

Influence of radiation therapy on patients with acromegaly depending on the age of patients

Khalimova Zamira , Issaeva Saodat

Aim: To evaluate the effectiveness of radiation therapy (RT) in patients with acromegaly, depending on the age of patients and the activity of pituitary adenomas.Materials and methods: The subject of the study were 50 patients (women-36, men-14) with acromegaly who received gammatherapy in a total dose of 45–60 Gr of 20–25 fractions every other day. The duration of the disease was 15 years on average. In general, the age of patients rang...

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ea0070aep1087 | Hot topics (including COVID-19) | ECE2020

Carotid ultrasound assessment in patients with acromegaly

Wang Yawen , Hammersen Stefanie , Moskopp Dag

Objective: Acromegaly is characterized by chronic hypersecretion of growth hormone (GH) with increased concentration of IGF-1. It is known that patients with acromegaly have a high risk of developing cardiovascular diseases. We evaluated vascular changes by performing echodoppler ultrasonography in our series of patients.Methods: Ultrasonographywas performed on 10 patients within one week after transsphenoidal surgery. The study includes 6 male and 4 fem...

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ea0070aep1088 | Hot topics (including COVID-19) | ECE2020

Cushing’s disease recurrence during peripartum period: A case report

Fellipe Carvalho Viola Luiz , Muniz Raquel , Stefanello Lariana , Massucati Negri Maurício , Warszawski Leila

Introduction: Even with a high incidence of infertility owing to the suppressive effects of hypercortisolism in the gonadal axis, either associated or not to hyperandrogenism and ovulatory dysfunction, Cushing’s syndrome (CS) during pregnancy has been reported. This could be due to a greater rate of CS among women in reproductive age; however, it is a rare condition, with fewer than 200 cases reported in the literature. In general, CS affects 2–25 people to every 1...

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ea0070aep1089 | Hot topics (including COVID-19) | ECE2020

A homozygous hypomorphic BRCA2 variant in primary ovarian insufficiency without cancer or Fanconi anemia trait

Heddar Abdelkader , Sandrine Caburet , Elodie Dardillac , Héléne Creux , Marie Lambert , Gabriel Livera , Lopez Bernard S , Misrahi Micheline

BRCA2, is a gene with a critical role in DNA repair and homologous recombination in somatic cells. Patients with BRCA2 biallelic mutations develop Fanconi Anemia (FA), a severe life-threatening condition characterized by pancytopenia and multiple malformations and malignancies, while women with monoallelic alteration are at high risk to develop breast or ovarian cancer (up to 60%). Primary Ovarian insufficiency (POI) affects 1% of women under forty and is a publi...

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ea0070aep1090 | Hot topics (including COVID-19) | ECE2020

Climacteric symptoms and stress management techniques in peri- and early postmenopausal women

Armeni Eleni , Augoulea Areti , Palaiologou Anastasia , Christidi Foteini , Soureti Anastasia , Alexandrou Andreas , Panoulis Konstantinos , Chroussos Georgios , Zervas Ioannis , Lambrinoudaki Irene

Introduction: The hypothalamic-pituitary-ovarian and/or adrenal axis as well as the autonomous nervous system affect significantly the intensity of menopausal symptoms Pre-existing levels of stress may affect the individual perception of menopausal symptoms. We aimed to evaluate the efficacy of a structured stress management program to reduce levels of stress and severity of climacteric symptoms, in a sample of middle-aged Greek women.Methods: The sample...

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ea0070aep1091 | Hot topics (including COVID-19) | ECE2020

Low FT3 serum values are associated with markers of disease severity, evaluated during the acute phase of COVID-19

Sciacchitano Salvatore , Giovagnoli Simonetta , D’Ascanio Michela , De Dominicis Chiara , Laghi Andrea , Anibaldi Paolo , De Vitis Claudia , Petrucca Andrea , Amodeo Rachele , Simmaco Maurizio , Napoli Christian , Mancini Rita , Ricci Alberto

Low T3 syndrome is a frequent finding in patients with critical illness, particularly in those admitted to intensive care units. It is generally considered an adaptive state of thyroid hormone (TH) economy, but many evidences indicate that it may represent a negative prognostic factor too. The prevalence and clinical relevance of the Low T3 syndrome in coronavirus infections has not been evaluated yet. We have measured thyroid hormone levels and analyzed anamnestic, epidemiolo...

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ea0070aep1092 | Hot topics (including COVID-19) | ECE2020

Cholesterol and Graves’ Orbitopathy (GO): ‘A new decision-making algorithm based on baseline low density lipoprotein cholesterol (LDLc) and early GO clinical response to parenteral corticosteroids’

Naselli Adriano , Moretti Diletta , Regalbuto Concetto , Luisa Arpi Maria , Logiudice Fabrizio , Frasca Francesco , Belfiore Antonino , Le Moli Rosario

Introduction: Parenteral corticosteroids (PC) are effective for the treatment of active moderate to severe (AMS) Graves’orbitopathy(GO). A correlation of GO activity with cholesterol has been described. No evidences are available about cholesterol levels and the clinical efficacy of PC in AMS-GO.Aim: Was to detect the predictive role of cholesterol on medium term clinical outcome of PC therapy in AMS-GO.Methods: We studied 87...

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ea0070aep1093 | Hot topics (including COVID-19) | ECE2020

Autoimmune thyroiditis has a protective role on papillary thyroid cancer: Insights from a new mouse model

Pani Fabiana , Yasuda Yoshinori , Di Dalmazi Giulia , Gabrielson Kathleen , Chalan Paulina , Mariotti Stefano , Caturegli Patrizio

The relationship between papillary thyroid cancer (PTC) and autoimmune thyroiditis remains controversial. To gain mechanistic insights, we developed a mouse model by combining three strains: BRAFv600E knock-in and TPO-CRE-ER transgenic to induce PTC upon tamoxifen injection, and NOD.H2h4 congenic to induce thyroiditis upon iodine administration.A total of 113 mice of the desired genotype (BRAF mutant homozygous, CRE transgenic hemiz...

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ea0070aep1094 | Hot topics (including COVID-19) | ECE2020

Identification of thyroid disease in pregnant women varies by analytical method and type of thyroid function test

Linding Andersen Stine , Astrup Christensen Peter , Knøsgaard Louise , Andersen Stig , Handberg Aase , Bo Hansen Annebirthe , Vestergaard Peter

Objective: Physiological alterations challenge the assessment of maternal thyroid function in pregnancy. It remains uncertain how the reference ranges vary by week of pregnancy, and how the classification of maternal thyroid disease vary by analytical method and type of thyroid function test.Method: Consecutively collectedserum samples from 6.282 pregnant women in the North Denmark Region, 2011–2013, were used for the measurement of thyrotropin (TS...

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ea0070aep1095 | Hot topics (including COVID-19) | ECE2020

Low serum IL-17A in pregnancy during second trimester is associated with an increased risk of subclinical hypothyroidism

Yang Qian , Zha Bingbing

Problem: Interleukin-17A (IL-17A) has a role in sustaining normal pregnancy. IL-17A is also associated with thyroid autoimmunity during pregnancy. This study sought to investigate whether IL-17A is a risk factor for thyroid dysfunction during pregnancyin women negative for thyroid autoantibodies.Methods of study: The study comprised 216 pregnant women with negative thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) during the second tr...

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ea0070aep1096 | Hot topics (including COVID-19) | ECE2020

Limited genetic overlap between Hashimoto´s thyroiditis and Graves´ disease in Swedish twins: A population-based study

Skov Jakob , Calissendorff Jan , Eriksson Daniel , Ludvigsson Jonas , Magnusson Patrik , Kämpe Olle , Bensing Sophie , Kuja-Halkola Ralf

Background: Hashimoto´s thyroiditis (HT) and Graves´ disease (GD) are known co-aggregate in families, but the magnitude and nature of a shared etiology is unknown. The aim of this study was to estimate the shared genetic influence on these diseases. In addition, we sought to examine if the heritability of HT and GD differs between men and women.Methods: We used national health registries to identify cases of HT and GD in a cohort of 110 814 Swe...

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ea0070aep1097 | Hot topics (including COVID-19) | ECE2020

Central hypothyroidism: Are patients undertreated?

Marlier Joke , Bruno Lapauw , T’sjoen Guy , Defreyne Justine

Introduction: Thyroid hormone (TH) replacement therapy in patients with central hypothyroidism (CHT) cannot be reliably guided by TSH levels. Guidelines suggest substitution doses between 1.2–1.6 µg/kg body weight, aiming for free thyroxine levels (fT4) prior to intake in the upper part of normal. However, variability in TH metabolism, concomitant treatments and inaccurate interpretation of TSH levels still puts patients with CHT at risk for inappropriate substituti...

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ea0070aep1098 | Hot topics (including COVID-19) | ECE2020

Rho-kinase (ROCK1 and ROCK2) gene polymorphisms in patients with Graves’ disease

Tabur Suzan , Oguz Elif , Demiryurek Tuncay

Graves’ disease (GD) is an autoimmune disease caused by autoantibodies binding to and activating the thyroid-stimulating hormone receptor (TSHR). Chronic stimulation of the TSHR results in a hyperactive thyroid gland and hyperthyroidism. The purpose of this study was to determine the association between Rho-kinase (ROCK1 and ROCK2) gene polymorphisms and GD in a Turkish population. A total of 142 patients with HT and 163 healthy control subjects were in...

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ea0070aep1099 | Hot topics (including COVID-19) | ECE2020

Data retrieval to provide thyroid hormone reference ranges and setpoints upon individualized characteristics

Tabesh Hadi , Hemmati Mostafa , Bazrafshan Hamidreza

Clinicians recognize patients persistently experience residual symptoms of thyrotoxicosis or hypothyroidism etc. despite having achieved circulating levels of TSH and FT4 within the conventional normal ranges. In fact, many pathological conditions affect preferred TSH and FT4. In addition, evidences indicate that the laboratory-quoted normal thyroid hormones as well as TSH reference range could not be always appropriate for everyone in clinical practice. In neonates, infants, ...

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ea0070aep1100 | Hot topics (including COVID-19) | ECE2020

The impact of strain elastography and 4d doppler in improving the presurgical evaluation of thyroid nodules with intermediate cytology results

Borlea Andreea , Mihaela Cepeha Cristina , Sporea Ioan , Cotoi Laura , Dana Stoian

Fine needle aspiration (FNA) is recommended for diagnosing thyroid nodules with suspicious ultrasound (US) features. Bethesda categories III and IV have conflicting management approaches: follow-up or thyroidectomy. This study aimed to evaluate a multimodal US assessment of the lesions in order to clarify the therapeutic strategy in intermediate cytology cases. 64 successive Bethesda III or IV cases were included. US evaluation consisted of greyscale US, qualitative strain ela...

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ea0070aep1101 | Hot topics (including COVID-19) | ECE2020

Measurement of calcitonin in nodular thyroid disease approach: The experience of a tertiary centre

Benido Silva Vânia , Teresa Pereira Maria , Carlos Oliveira José , Freitas Cláudia , Helena Cardoso Maria

Introduction: It is universally accepted that calcitonin (CT), a hormone secreted by the parafollicular cells of the thyroid, is a specific, sensitive and early marker of Medullary Thyroid Carcinoma (CMT), with higher diagnostic accuracy than fine needle aspiration biopsy(FNAB). However, the routine measurement of serum CT during assessment of nodular thyroid disease (NTD) remains controversial due to rarity of this cancer and possible false positive results.<p class="abst...

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ea0070aep1102 | Hot topics (including COVID-19) | ECE2020

Microarray profile of B cells from Graves’ disease patients reveals biomarkers of proliferation

Li Xiaoying , Zha Bingbing , Yang Qian

B lymphocytes are the source of autoantibodies against the thyroid--stimulating hormone receptor (TSHR) in Graves’ disease (GD). Characterization of autoimmune B-cell expression profiles might enable a better understanding of GD pathogenesis. To reveal this, the expression levels of long noncoding RNAs (lncRNAs) and mRNAs (genes) in purified B cells from patients with newly diagnosed GD and healthy individuals were compared using microarrays, which elucidated 604 differe...

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ea0070aep1103 | Hot topics (including COVID-19) | ECE2020

Application of fuzzy logic controller to optimize thyroid hormone replacement therapy

Tabesh Hadi , Hemmati Mostafa , Bazrafshan Hamidreza

Conventionally, physicians adjust LT4 dose by clinical estimation based on their experiences and available guidelines; however, no computational algorithm exists to support their decisions. The objective of this study is to build an artificial decision support system utilizing fuzzy logic to propose a proper LT4 dosage regimen. We used THYROSIM software as the model of human thyroid hormone regulation to simulate a virtual thyroidectomized patient, setting the secretion rates ...

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ea0070aep1104 | Hot topics (including COVID-19) | ECE2020

Hypothyroidism in utero suppresses pituitary-adrenal function in the ovine fetus near term: Implications for fetal maturation and the timing of birth

Camm Emily , Inzani Isabella , De Blasio Miles , Davies Katie , Lloyd India , Peter Wooding F. B. , Fowden Abigail , Forhead Alison

Development of the fetal hypothalamic-pituitary-adrenal (HPA) axis is important for normal maturation of the fetus and the timing of parturition. In hypothyroid fetuses, gestational length may be prolonged and maturational processes delayed, although the role of the HPA axis is unknown. This study investigated the effects of hypothyroidism before birth on the structure and function of the anterior pituitary and adrenal glands in fetal sheep near term.All...

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ea0070aep1105 | Hot topics (including COVID-19) | ECE2020

MTHFR C677T polymorphism frequency and DNA methylation status in Georgian population with non-autoimmune hypothyroidism

Kvaratskhelia Tamar , Abzianidze Elene , Kakulia Mzeona , Surmava Sandro , Asatiani Ketevan , Kvaratskhelia Eka

Introduction: Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism results in thermolabile, reduced functioning enzyme and predicts hyperhomocisteinemia and altered DNA methylation. On the other hand, several studies indicated a higher plasma homocysteine (Hcy) levels in patients with primary hypothyroidism than in healthy, euthyroid individuals, including some experimental studies that indicated decreased MTHFR activity in hypothyroid patients. We cond...

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ea0070aep1106 | Hot topics (including COVID-19) | ECE2020

Dietary interventions for the treatment and management of autoimmune thyroid disease: A systematic review and meta-analysis

Correia Jorge , Meraj Hafsa , Ahmad Maaz , Mariela Marroquin Ramirez Lucia , Gómez Corral Laura , Genton Graf Laurence , Pataky Zoltan

Background: There is evidence that dietary interventions can reduce antibody levels in patients with autoimmune thyroid disease (ATD), which can have a beneficial effect on the clinical manifestations of the disease. The aim of this study was to review the literature regarding the different types of dietary supplementations and their effectiveness in the management of ATDs.Methods: Using a predefined search strategy, four databases were searched (PubMed,...

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ea0070aep1107 | Hot topics (including COVID-19) | ECE2020

Prevalence of thyroid disease in end-stage renal disease patients

Cotoi Laura , Amzar Daniela-Georgiana , Andreea Borlea , Cepeha Cristina , Dana Stoian

Introduction: Chronic kidney disease is a rising cause of morbidity and mortality in developed countries, including end-stage renal disease (ESRD). Endocrine disorders are highly common endocrine complications among patients with chronic kidney disease, including those receiving dialysis. The prevalence of thyroid comorbidities in patients with chronic kidney disease is documented higher than in normal population.Materials and methods: A cross-sectional ...

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ea0070aep1108 | Hot topics (including COVID-19) | ECE2020

Elastographic patterns in the evolution of Graves’ disease: An observational study

Mihaela Cepeha Cristina , Paul Corina , Andreea Borlea , Cotoi Laura , Dana Stoian

Introduction: The most common cause of hyperthytoidism is considered to be Graves disease (also known as Basedow disease), an autoimuune disorder. The most recent technique developed for measuring the tissue elasticity is considered to be sonographic elastography.Aim: This study was conducted in order to determinate if any significant changes could be encountered in the elastographic patterns of the different evolutive stages of Graves’ disease.</p...

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ea0070aep1109 | Hot topics (including COVID-19) | ECE2020

Thyroid imaging reporting and data systems (TI-RADS) and advanced ultrasound techniques: Compared stratification of the cancer risk

Borlea Andreea , Cotoi Laura , Sporea Ioan , Mihaela Cepeha Cristina , Dana Stoian

The prevalence of thyroid nodules is increasing in the general population, thus detecting the ones at risk represents the main concern in clinical practice. The aim of the study was to compare four important Thyroid Imaging and Reporting Data Systems (TI-RADS) and assess how elastography and 4D Color Doppler vascularity evaluation improve the estimation of the malignancy risk. 133 nodules were evaluated by means of conventional ultrasound (US), elastography and 4D Doppler. All...

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ea0070aep1110 | Hot topics (including COVID-19) | ECE2020

The value of real-time strain elastography in the assessment of diffuse thyroid pathology

Mihaela Cepeha Cristina , Paul Corina , Andreea Borlea , Cotoi Laura , Dana Stoian

Introduction: Autoimmune thyroid diseases are among of the most important causes of thyroid disfunction. Chronic Autoimmune Thyroiditis (CAT)and Graves’ Disease (GD) are the major causes of hypothyroidism and hyperthyroidism, respectively.Aim: The aim of this studywas to evaluate the efficiency of strain elastography in the differential diagnosis of Chronic Autoimmune Thyroiditis (CAT) and Graves’ disease.Material:...

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22nd European Congress of Endocrinology

BiosciAbstracts