Searchable abstracts of presentations at key conferences in endocrinology
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22nd European Congress of Endocrinology

05 Sep 2020 - 09 Sep 2020

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Europe's leading endocrinology congress showcasing the very best in the study and treatment of endocrine disorders.

ePoster Presentations

Pituitary and Neuroendocrinology

ea0070ep280 | Pituitary and Neuroendocrinology | ECE2020

Rare occurence of two metachronous bladder tumours, of which one is neuroendocrine

Iulia Greere Daniela Ioana , Burcea Iulia Florentina , Dusceac Roxana , Bottiglieri Luca , Poiana Catalina

Introduction: Neuroendocrine tumors (NETs) are rare tumors that originate in cells from the neural crest, widely distributed in the body. Genitourinary (GU) NETs occurring in the bladder represent less than 1% of these primary malignancies. We present the case of a patient with two metachronous bladder tumors, of which one is NET.Case report: Male patient, 52–year-old, ex–smoker, known with hypertension, dyslipidemia and benign prostatic hype...

ea0070ep281 | Pituitary and Neuroendocrinology | ECE2020

Inspection of the internal jugular vein pulse appears to be superior to impedance analysis for determination of volemia in a Hyponatremia outpatient clinic

Lopez Nevado Celia , Vadillo Sandra , Villareal Adriana , Ruiz Jorge , Cuesta Martin , Perez Candel Xavier , Barrio Elvira , Larrad Angelica , Calle Pascual Alfonso , Runkle Isabel

Measurement of electrical impedance has been proposed as a way to determine whether a hyponatremic patient is hypovolemic or euvolemic. We compare the usefulness of the physical examination (PE) with bioimpedance for determination of volemia in an outpatient hyponatremia clinic.Method: Descriptive prospective analysis. 11 patients attended at the hyponatremia clinic of a tertiary hospital were evaluated. Impedance was measured by a SECA, indicating the p...

ea0070ep282 | Pituitary and Neuroendocrinology | ECE2020

Pituitary metastasis as a rare cause of diabetes insipidus

Kalthoum Mehdi , Kandara Hajer , Adel Meriem , Jmel Manel , Gharbi Radhouen , Kammoun Ines

Introduction: The most common cause of diabetes insipidus is idiopathic. In some rare cases, it can be secondary to metastasis to hypothalamic–pituitary region.Case report: We report a case of 68-years-old female patient presented to our clinic with complaints of polyuria and polydipsia. She had medical history of breast adenocarcinoma 6 years ago treated with surgery, neoadjuvant radiotherapy and 8 cycles of chimiotherapy. On physical examination ...

ea0070ep283 | Pituitary and Neuroendocrinology | ECE2020

Severe hypoglycemia in diabetic patient with long lasting undiagnosed empty sella syndrome

Sausa Sintija , Seisuma Dace , Steina Liva , Pirags Valdis

A 45 year old female was referred to the Endocrinology department with complains of severe fatigue and weakness from basic daily activities, also irregular menstrual circle during last five years. Twelve years back she had twin pregnancy, premature delivery on 29th week, and absence of lactation. Afterwards she gradually lost 6 kg of her body weight and her menstrual circle become sparse and disappeared five years back. 1.5 years ago type 1 diabetes was diagnosed (C-peptide be...

ea0070ep284 | Pituitary and Neuroendocrinology | ECE2020

Secondary amenorrhea and large uterine myomas in a patient with acromegaly

Borozan Sanja , Sparavalo Rada

Menstrual irregularity is common in women with acromegaly, occurring in 40–84% of patients. Its pathogenesis is still not well established although it is usually attributed to prolactin excess and/or gonadotropin deficiency. Also, since the presence of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) receptors is demonstrated in the myometrium, a pathogenetic role of GH in the development of myoma is examined through different studies. Moreover, some of them ...

ea0070ep285 | Pituitary and Neuroendocrinology | ECE2020

Acromegaly and glucose metabolism – A case report

Denes Judit , Hargittay Csenge , Hubina Erika , Görömbey Zoltán , Oláh Dóra , Kovács László , Góth Miklós

Acromegaly is a rare disorder caused by growth hormone (GH) and insulin-like growth factor I (IGF-I) overproduction, associated with increased morbidity and mortality. It has different complications, among which insulin resistance, prediabetes and diabetes mellitus are substantial. GH affects glucose metabolism through different mechanisms. The therapy of GH overproduction (for example surgical or radiotherapy) improves glucose metabolism, while different types of medical ther...

ea0070ep286 | Pituitary and Neuroendocrinology | ECE2020

Macroprolactinoma in an adolescent girl with secondary amenorrhea – A case report

Venaki Evangelia , Kakoulidis Ioannis , Linardi Anastasia , Petychaki Foteini , Togias Stefanos , Michou Aikaterini , Ilias Ioannis , Koukkou Eftychia

Introduction: Prolactinomas are rarely found in adolescents under 15 (incidence 0.1/1.000.000). They account for 50% of all types of pituitary adenomas in childhood and adolescence (2% of intracranial tumors). The mean time from onset of symptoms to diagnosis is 2.4 years on average for girls. In cases of macroadenomas, TSH and GH deficiency may coexist. The gold standard primary therapy is dopamine agonists. In case of non-response, or the presence of large prolactinomas with...

ea0070ep287 | Pituitary and Neuroendocrinology | ECE2020

Obesity in endocrine connections- a finding of nonfunctional pituitary macroadenoma

Jakubíková Iva , Kratochvílová Simona , Brunová Jana , Hána Václav

Introduction: Spacious sellar area predisposes to late diagnosis of nonfunctional pituitary adenomas and in males even the functional ones such as prolactinomas. Rising prevalence of obesity is mainly associated with sedentary lifestyle and excess of food intake. Only in rare cases has endocrine etiology such as Cushing disease, hypothyroidism or hypothalamic disorders.Case-report: A 29-year-old man was admitted to our hospital for chest pain, with a hig...

ea0070ep288 | Pituitary and Neuroendocrinology | ECE2020

From visual disturbance to thyroid cancer: An unexpected journey

Barker Florence , Grant Bonnie , Stojanovic Nemanja , Hossain Belayat , Casey Edel , Hawkins Anna , Chawda Sajiv , Syed Imran , Pollock Jonathan , Pittathankal Antony , Nikookam Khash

A 28-year-old female presented to the optician with visual disturbance, lethargy and headaches, which were initially attributed to long hours of IT work. Despite a trial of eye exercises she experienced worsening colour vision and acuity in the right eye, hence a further consultation with an optometrist. Examination did not reveal a visual field defect. Visual acuity was 6/6 with 9/17 ishihara plates in the right eye and 5/6 with 17/17 ishihara plates in the left. A further re...

ea0070ep289 | Pituitary and Neuroendocrinology | ECE2020

Clinical and endocrinological evaluation of patients with empty sella

Nur Kebapci Medine , Kesebi Isganderov Duygu , Yorulmaz Goknur , Akalin Aysen , Efe Belgin

Empty sella (ES) is characterized by herniation of the subarachnoid space within the sella, compression and flattening of the pituitary gland. Stretching of the pituitary stalk may also be seen. Empty sella is a frequent finding (5–23%) in autopsy series while it is < 0.01% in persons who undergo medical attention. Meanwhile there is an increase in sellar emptiness with age. Regarding pathophysiology and etiology, it may be primary to the incompetence of the diaphrag...

ea0070ep290 | Pituitary and Neuroendocrinology | ECE2020

Clinical and hormonal pecularities of acromegaly patiernts from ukrainian centre

Khyzhnyak Oksana , Miroslava Mykytyuk , Roman Nikolaiev , Mykola Guk , Uirii Karachentsev , Tetiana Gavrysh

Introduction: Acromegaly (ACRO) is a rare disease of an excessive somatic growth and distorted proportions arising from hypersecretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). The aim Of this study is to investigate basic demographic parameters such as the age and gender related features, age at diagnosis of the disease, its clinical manifestations, biochemical control and structure of complications in Ukrainian patients with ACRO in a single neuroendoc...

ea0070ep291 | Pituitary and Neuroendocrinology | ECE2020

Cabergoline treatment: The ethics around side effects

Ratnasabapathy Risheka , Patel Bijal , Qayum Ambreen , Zaman Shamaila , Behary Preeshila , Meeran Karim , Martin Niamh

Cabergoline has long been used to treat prolactinomas for symptomatic, radiological and biochemical resolution of pituitary tumours. As clinicians we are well-versed at screening for physical side effects, but are we holistic enough? We present two cases illustrating the damaging social consequences of cabergoline treatment for prolactinomas.Case 1A 49-year-old married father of two presented with a seizure in April 2018. MRI showe...

ea0070ep292 | Pituitary and Neuroendocrinology | ECE2020

Quality of life in patients with Cushing’s syndrome in remission: 10-year follow-up

Santos Alicia , Resmini Eugenia , Martinez Momblan Mª Antonia , Medina Marc , Webb Susan

Introduction: Cushing’s syndrome (CS) has been associated with low quality of life, even after biochemical cure. However little data is available on long term follow-up. The aim of the study was to analyse 10-year follow-up of quality of life (QoL) in patients in remission of CS.Methods: 24 patients in remission of CS followed in Hospital Sant Pau were included in this study (3 men, 21 pituitary origin, 3 adrenal; mean baseline age 45.1 ± 14.1...

ea0070ep293 | Pituitary and Neuroendocrinology | ECE2020

Pasireotide LAR in acromegaly resistant to first generation somatostatin analogs – single-center prospective interventional study

Majos Agnieszka , Stelmachowska-Banaś Maria , Czajka-Oraniec Izabella , Zgliczyński Wojciech

Introduction: The treatment of choice in persistent acromegaly after transsphenoidal adenomectomy is pharmacological treatment with first generation somatostatin analogs. They are effective in 25% to 45% of patients. Second generation somatostatin analog – pasireotide seems to be more effective.Aim: The aim of the study was to assess the efficacy and safety of pasireotide LAR in acromegaly patients resistant to first generation somatostatin analogs...

ea0070ep294 | Pituitary and Neuroendocrinology | ECE2020

Challenges in management and pharmacotherapeutic strategy in patients with a prolactinoma and neuropsychosis; a case presentation and literature review

Moolla Ahmad , Hope David , Hill Neil , Meeran Karim

A 36-year-old male presented to the emergency department with a 24-hour history of mutism, paranoia and 3-day history of social withdrawal. He was unable to engage with healthcare professionals and the history was elicited from his mother. Due to a background of mild depression, an acute psychotic diagnosis was initially pursued. A CT scan on admission revealed a large pituitary lesion. A pituitary MRI scan thereafter demonstrated a large 25 × 30 × 18 mm sellar and s...

ea0070ep295 | Pituitary and Neuroendocrinology | ECE2020

Pre-operative full blood count, C-reactive protein and serum inflammation-based scores may predict aggressive or refractory disease in patients with pituitary adenomas

Marques Pedro , de Vries Friso , van Furth Wouter , Korbonits Marta , Biermasz Nienke , Pereira Alberto M

Introduction: Full blood count (FBC), C-reactive protein (CRP), albumin and serum inflammation-based scores reflect systemic inflammation and predict outcomes in oncological patients. While these are increasingly used in cancer, little is known in pituitary adenomas (PAs). We aimed to characterise FBC and inflammation-based scores in patients with PAs and investigate the usefulness of such parameters in predicting aggressive/refractory disease.Methods: W...

ea0070ep296 | Pituitary and Neuroendocrinology | ECE2020

Prevalence of hypocortisolism and replacement treatment after transsphenoidal surgery pituitary adenomas

del Mar Roca-Rodriguez Maria , Manuel Cornejo-Domínguez Jesús , Vidal-Suárez Álvaro , Muriel-Cueto Pedro , Iglesias-Lozano Irene , Gavilán-Villarejo Inmaculada , Aguilar-Diosdado Manuel

Aim: Evaluation of hypocortisolism and replacement treatment after transsphenoidal surgery pituitary adenomas and subsequent follow-up in Endocrinology offices.Material and methodWe conducted a retrospective intra-subject study of patients with pituitary adenomas who were undergone surgery. Clinical and analytical data were evaluated at baseline and after surgery between 2012–2018.Results: 30 patients (...

ea0070ep297 | Pituitary and Neuroendocrinology | ECE2020

Treatment outcomes of acromegaly: A single-centre experience

Snieskiene Aiste , Juskiene Rasa , Abraitiene Agne , Visockiene Zydrune

Introduction: The purpose of this study was to evaluate treatment options and effectiveness in patients with acromegaly.Methods: The study involved retrospective data collection from charts of 75 patients with acromegaly who was treated at Vilnius University Hospital Santaros klinikos.Results: Patient population consisted of 21 males (28%) and 54 females (72%), mean age at diagnosis 52 ± 13 years. In most of the cases, macroad...

ea0070ep298 | Pituitary and Neuroendocrinology | ECE2020

Dabigatran-induced pituitary apoplexy in young patient: A case report

Cosmina Mogos Iustina , Mitescu Andrea , Tulin Raluca

Introduction: Pituitary apoplexy is defined as the acute onset of clinical symptoms associated with hemorrhage or infarction within a normal pituitary gland or previously known pituitary adenoma.Case report: A 47-year-old hypertensive Caucasian male patient with a known pituitary macroadenoma and family history of pituitary adenomas, was treated with thromboprophylaxis after a meniscus surgery. He was on treatment with non-steroidal anti-inflammatory med...

ea0070ep299 | Pituitary and Neuroendocrinology | ECE2020

Non-functioning pituitary adenomas – clinical presentation and management, experience of a tertiary centre in Romania

Mustata Theodor , Martin Sorina , Mihop Delia , Predescu Andrada , Parfeni Ovidiu , Sirbu Anca , Barbu Carmen , Fica Simona

Background and Aim: Non-functioning pituitary adenomas (NFPAs) are hormonally inactive adenohypophyseal tumors. The absence of hormone hypersecretion and the lack of clinical manifestations delay the diagnosis and therefore symptoms of mass effect are frequently seen in NFPAs. The primary endpoint of this study was to evaluate the clinical presentation of patients with NFPAs and their therapeutic management. The secondary endpoint was to identify how gender and tumor size impa...

ea0070ep300 | Pituitary and Neuroendocrinology | ECE2020

Development of a digital patient-provider communication tool to facilitate shared decision making for patients with non-functioning pituitary adenomas: InvolveMe

Seljelid Berit , Abelsen Kari , Krabbe Line C. , Bollerslev Jens , Varsi Cecilie , Solberg Nes Lise , Børøsund Elin

Background: Patients report a variety of persisting symptoms that reduce their quality of life after treatment for non-functioning pituitary adenomas (NFPA). Digital tools have the potential to improve patient-provider communication and patient outcomes by giving opportunities for patients to report their current status, which can be helpful in recognizing symptoms and identifying needs. Mapping patients’ symptoms, needs and preferences prior to the consultation can aid ...

ea0070ep301 | Pituitary and Neuroendocrinology | ECE2020

Can you predict the success of surgery in cushing’s disease?

Moreno-Moreno Paloma , Soto-Moreno Alfonso , Fajardo-Montañana Carmen , Camara-Gómez Rosa , Luque Raul M , Ángeles Gálvez-Moreno María

Objective: Cushing’s disease (CD) is difficult to diagnose because of its rarity and because its most common symptoms can overlap with those of other more common conditions. Remission rates in the postoperative vary between 55–85%. Overall, the mean time to diagnosis was 38 months. The objective of this study was to describe whether there is any pre-surgical clinical data that predicts CD remission after TSS.Patients and Methods: Retrospectiv...

ea0070ep302 | Pituitary and Neuroendocrinology | ECE2020

Long-term outcomes of prolactinoma-related pregnancies

Tanrikulu Seher , Ciftci Dogansen Sema , Soyluk Selcukbiricik Ozlem , Yarman Sema

Objective: The aim of the study is to evaluate both the long-term consequences of exposure to dopamine agonists (CAB and BRC) at the beginning and during pregnancy, and the effects of pregnancy on remission.Methods: Thirty-seven prolactinoma patients who developed 58 pregnancies while receiving DAs treatment were included in this retrospective study. Age of gestation; both maximum residual tumor diameter and PRL levels before conception; the course of pr...

ea0070ep303 | Pituitary and Neuroendocrinology | ECE2020

Metastasis of lung cancer to two different endocrine organs

Sebile Dökmetaș Hatice , Dökmetaș Meriç , Kılıçlı Fatih , Cila Ayșenur , Olmușçelik Oktay

Both pituitary and adrenal gland metastases of lung cancer are very rare. A 79-year-old male patient with diabetes mellitus and hypertension was admitted to our hospital because of a mass in the lungs of the thorax CT. TSH: <0.005 UIU/ml (0.27–4.2), free T4: 0.794 ng/dl (0.93–1.7). Other pituitary hormones were also examined: FSH: 0.708 mIU/ml (1.5–12.4), LH: <0.1 mIU/ml (1.7–8.6), prolactin: 12.7 ng/ml (4.04–15.2), total testosterone: &#6...

ea0070ep304 | Pituitary and Neuroendocrinology | ECE2020

Bilateral inferior petrosal sinus sampling in a cohort of patients with acth dependent cushing´s syndrome in a tertiary hospital

María García Moreno Rosa , Moreno Parro Isabel , Ortiz Sánchez David , Frutos Remedios , Gómez Rioja Rubén , Álvarez Escolá Cristina

Objectives: To describe the results of the bilateral inferior petrosal sinus sampling (BIPSS) performed in our hospital for differential diagnosis between Cushing disease (CD) and ectopic ACTH secretion (EAS), and evaluate if CRH stimulation during this test improves its diagnostic accuracy.Material and Methods: We retrospectively review 29 BIPSS performed in 26 patients (4 men, 22 women), with mean age of 44.7 year-old (range 28–69), diagnosed wit...

ea0070ep305 | Pituitary and Neuroendocrinology | ECE2020

A case series of hypopituitarism presenting as nocturnal hypoglycemia in patients with type 2 diabetes mellitus

Gupta Vishal , Teli Vaishali

We describe four female patients with T2DM, presenting with nocturnal dizziness (ND), low capillary blood glucose & low BP, that was partially relieved with oral glucose & salt water. C1: MB 66 years, on background of hypertension (HT, valsartan + hydrochlorthiazide (HCT) + amlodipine (AM) ), hypothyroidism (T4D) (levothyroxine 700 mg/week) & IHD (pEF) presented, 3 years into her diagnosis, A1c 52 mmol/mol, with unsteady gait, frequent falls (normal-neurolo...

ea0070ep306 | Pituitary and Neuroendocrinology | ECE2020

Clinical description and management in a series of macroprolactinomas

García-García-Doncel Lourdes , Baena-Nieto Gloria , Marquez-Pardo Rosa

Introduction: The purpose of this study was to describe the clinical characteristics of patients with macroprolactinoma in a second level Hospital.Methods: Retrospective data collection of patients diagnosed with macroprolactinoma between 2002 and 2017 at Jerez University Hospital.Results: Complete Data were obtained from 22 patients. The mean age at diagnosis was 40.32 ± 18.3 years (men: 52.9 ± 14.2, women: 27.7 ± 1...

ea0070ep307 | Pituitary and Neuroendocrinology | ECE2020

Curability rate of cushing’s disease 1 year posttreatment

Verdes Andreea , Ghenoiu Sandra , Capatina Cristina , Poiana Catalina

Background: Cushing’s disease is characterized by chronic ACTH hypersecretion, leading to hyperplasia of the adrenal zonae reticularis and fasciculata and, therefore, increased secretion of cortisol, androgens and DOC. Cushing’s disease is the most common form of Cushing’s syndrome, being responsible for approximately 80% of reported cases.Aim: To evaluate the curability rate of Cushing’s disease 1 year postoperatively.<p clas...

ea0070ep308 | Pituitary and Neuroendocrinology | ECE2020

Insipidus diabetes and vaginal ulcers... evidence for the diagnosis of langerhans cell hypophysitis

Correia Sara , Melo Gustavo , Alves Helena , Almeida Lucia , João Oliveira Maria , Ramalho Diogo

Introduction: Langerhans Cell Histiocytosis (HCL) is a rare granulomatous disease, unknown etiology, with a wide clinical spectrum. The pituitary is affected in 25% of cases, with diabetes insipidus being the earliest and most frequent feature. Although it is more common in pediatric age, it can also be developed by adults.Clinical case: A 39-year-old, caucasian, woman presents with polydipsia with 5L/day of water and an appetite for cold drinks, polyuri...

ea0070ep309 | Pituitary and Neuroendocrinology | ECE2020

Functional gonadotroph adenoma

Besrour Chayma , Chadia Zouaoui , Amel Jaidane , Haroun Ouertani

Introduction: The pituitary adenoma is the most frequent begnin pituitary tumor. They are labeled based on their size, tumors smaller than 1 cm called microadenomas and tumors bigger than 1 cm called macroadenomas. Moreover, they can be functional or non functional. Among the functional ones, gonadotroph adenomas represent 15 to 20%.ObservationWe report the case of a 27 years old women, who consulted for secondary amenorrhea for 1 ...

ea0070ep310 | Pituitary and Neuroendocrinology | ECE2020

Familial X-linked kallman syndrome associated with ptosis, case series

Elamin Yasir , Hussain Al-Qahtani Mohammad , Mohammed Alabdrabalnabi Fatimah , Abdulwahed Al Saeed Zahra

Kallmann syndrome is a rare congenital hypogonadotropic hypogonadism with variable degrees of hyposomia to anosmia. This syndrome can be transmitted as autosomal dominant, autosomal recessive and X-linked inheritance pattern. We are reporting two cases of young male siblings (17 and 16 years old) who are the offspring of unrelated parents, presenting with delayed puberty and both were complaining of hyposmia. Their older brother, aged 24 years, was diagnosed with isolated hypo...

ea0070ep311 | Pituitary and Neuroendocrinology | ECE2020

The comparison of nocturnal and fasting ghrelin concentration in children with growth hormone deficiency and with idiopathic short stature

Stawerska Renata , Kolasa-Kicinska Marzena , Kołecka-Rajewska Sylwia , Smyczyńska Joanna , Hilczer Maciej , Lewinski Andrzej

Introduction: Ghrelin - a growth hormone (GH) secretagogue - presents a circadian rhythm with higher nocturnal concentration (similar to GH). As daily ghrelin production depended on food intake and nutritional state, we decided to assess ghrelin concentration at 60th at 90th minute after falling asleep and at 6:00 am (after 12 hours of fasting), and compare the results to determine the differences between nocturnal and morning ghrelin release in short children, both with idiop...

ea0070ep312 | Pituitary and Neuroendocrinology | ECE2020

Multiple endocrine neoplasia 1, 4 or simple concomitance ?

Chiriac Bianca , Christina Ungureanu Maria , Leustean Letitia , Rosu Andreea , Neagu Georgiana , Protop Madalina , Ambarus Ioana , Preda Cristina

Introduction: The association between pituitary adenoma and hyperparathyroidism is the main feature of multiple endocrine neoplasia (MEN) 1 but also for a novel MEN4 syndrome. Germline mutations in the cyclin-dependent kinase (CDK) inhibitor 1b gene (CDKN1B) were identified in patients with MEN4. The most common phenotype of the 19 established cases of MEN4 that have been described since now is primary hyperparathyroidism (PHPT) followed by pituitary adenomas. There are a limi...

ea0070ep313 | Pituitary and Neuroendocrinology | ECE2020

Radiotherapy in acromegaly: a single centre experience

Rezic Tanja , Skoric Polovina Tanja , Kraljevic Ivana , Solak Mirsala , Zibar Tomšić Karin , Balasko Anne-Marie , Dusek Tina , Heinrich Zdravko , Kastelan Darko

Background: Radiotherapy (conventional and/or radiosurgery) is an effective treatment option in patients with acromegaly when biochemical control of the disease cannot be achieved by medication and/or surgery. Purpose: The aim of our study was to evaluate the efficacy of gamma-knife radiosurgery or conventional radiotherapy in the treatment of GH-secreting pituitary adenomas.Materials and methods: We conducted a retrospective analysis of 22 acromegaly pa...

ea0070ep314 | Pituitary and Neuroendocrinology | ECE2020

Malabsorption of levothyroxine sodium tablet in a patient with neuroendocrine gastric tumor, follow-up

Boskovic Olivera , Smolovic Brigita , Lazovic Ranko

Multiple dose adjustments can sometimes be inefficient in reaching eumetabolic state in patients with hypothyroidism treated by levothyroxine sodium tablets.We report a case of 46-year-old female who has been on levothyroxine sodium tablet replacement therapy since 2004 without ever reaching eumetabolic state. As sellar MRI ruled out pituitary adenoma, investigation perform absorption test with 300 mg levothyroxine and test was positive in aspect of pres...

ea0070ep315 | Pituitary and Neuroendocrinology | ECE2020

What we found the hidden cause of SIADH?

Yin Yin , Htet Aung Htet , Simini Giulia , Alsabbagh Samer

A 74-year- old gentleman was found to be hyponatraemic when he returned from birds watch trip with cellulitis of lower legs. He was generally fit and well apart from hypertension for which he had been on Amlodipine and Irbesartan. He was admitted with severe hyponatremia in July 2019 and was diagnosed with idiopathic SIADH as evidence of low serum osmolality (252 mosm/kg), high urine sodium (41mmol/l) and high urine osmolality (657mmol/kg). His Amlodipine and Irbesartan were r...

ea0070ep316 | Pituitary and Neuroendocrinology | ECE2020

Aggressive evolution of a neuroendocrine tumors of the lung (Lu-NETs) - case report

Galesanu Corina

Background: Lu-NETs are a heterogeneous family of neoplasms ranging from quite indolent lesions with extremely aggressive tumors with very poor prognosis. These neuroendocrine entities are further summarized into two groups according to their biological aggressiveness: Well-differentiated: carcinoids typical (G1) and atypical (G2).Poorly-differentiate: SCLC (Combined) and LCNEC (Combined) (G3). Alarm signal on the aggressive evolution of the SCLCCase rep...

ea0070ep317 | Pituitary and Neuroendocrinology | ECE2020

Hypopituitarism and vitamin D deficiency in a patient with primary CD8+ T-cell deficiency.

Chehida Anaam Ben , Oueslati Ibtissem , Madhi Wiem , Yazidi Meriem , Khessairi Nadia , Chaker Fatma , Chihaoui Melika

Introduction: CD8+ T-cell deficiency is a feature of many chronic autoimmune diseases. Its association with vitamin D deficiency was described and it has been suggested that vitamin d deficiency contribute to the increase of the incidence and the progression of autoimmune diseases.Herein we report a case of hypopituitarism and vitamin D deficiency in a patient with CD8+ T-cell deficiency.Observation: A 28-year-old woman was...

ea0070ep318 | Pituitary and Neuroendocrinology | ECE2020

Silent corticotropic adenoma revealed by headache

Ijdda Sara , Bouizammarne Ilham , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Silent corticotropic adenoma (SCA) is defined by the absence of clinical manifestations of Cushing’s disease despite the presence of ACTH and/or its precursors in tumor cells. It is a rare entity that represents 10% of pituitary tumors. It is known for its increasing expansion. Its clinical presentation is dominated by symptoms of tumor mass effect. We report the case of a silent corticotropic adenoma revealed by headache.Case report:...

ea0070ep319 | Pituitary and Neuroendocrinology | ECE2020

Endocrine pathology hidden by IUD

Ichiche Malika , Laura Iconaru

Introduction: Amenorrhea is a condition resulting from dysfunction of the hypothalamus, pituitary, ovaries, uterus, or vagina. Hyperprolactinemia is a relatively common endocrine disorder that produces amenorrhea by suppressing hypothalamic GnRH secretion. We describe a patient who had a Levonorgestrel intrauterine device (UID) since 5 years and who presented with amenorrhea in association with a macroprolactinoma.Case report: A 45 year- old -woman prese...

ea0070ep320 | Pituitary and Neuroendocrinology | ECE2020

Lateralized sixth cranial nerve palsy after inferior petrosal sinus sampling

Helvacı Burçak , Houssein Mehdi , Dilek Dellal Fatma , Yuce Gokhan , Burçak Polat Şefika , Ersoy Reyhan

Introduction: Inferior petrosal sinus sampling (IPSS) is the gold standard test to differentiate Cushing’s disease from ectopic Cushing syndrome. IPSS may cause severe complications; however, overall rates are low. Subarachnoid hemorrhage (SAH) has been rarely reported after IPSS. Here we report a case who developed hypertensive emergency, left 6th cranial nerve palsy, and SAH after IPSS.Case: A sixty-two years-old female patient had a history of h...

ea0070ep321 | Pituitary and Neuroendocrinology | ECE2020

Infundibulo-hypophisitis with other metabolic disorders

Poshi Klodi , Ylli Agron , Haxhiraj Adela , Hysi Geri , Spahija Pranvera , Hyka Besa , Hoxha Violeta , Ylli Dorina , Kermaj Marjeta , Furrerraj Thanas , Toti Florian , Qehajaj Denisa

Introduction: Infundibulo - hypophisitis is a rare type neuroendocrine disorder characterized by autoimmune inflammation and various pituitary disfunction. It currently has no clear diagnosis criteria.We present the 26 years–old women, first diagnosed with infundibular neurohypophisitis with clinical Diabetes Insipidus and later with other metabolic disorders.Case description: The patient, female, 26 years old came in the emergency room with extrem...

ea0070ep322 | Pituitary and Neuroendocrinology | ECE2020

Heart failure as a first manifestation of acromegaly - A case report

Sagova Ivana , Pavai Dusan , Dragula Milan , Kantarova Daniela , Vanuga Anton , Vaňuga Peter

Acromegaly is a rare disease, which is mainly caused by benign tumour of the pituitary gland. Long-term presence of elevated growth hormone (GH) and insulin like growth factor 1 (IGF-1) levels accompanying this disease is associated with rheumatologic, cardiovascular, pulmonary and metabolic complications. Cardiovascular complications of acromegaly include a cardiomyopathy, arterial hypertension, arrhytmias, valvulopathy as well as endothelial dysfunction. Cardiovascular disea...

ea0070ep323 | Pituitary and Neuroendocrinology | ECE2020

Association of an empty sella and grave’s disease in a patient with acromegaly

Halloul Imen , Abdelkarim Mzoughi Asma Ben , Slim Ahlem , Saad Ghada , Othman Wafa Ben , Hasni Yosra , Maaroufi Amel , Kacem Njah Maha , Chaieb Molka , Ach Koussay

Introduction: Acromegaly is, in most cases, caused by growth hormone (GH) -secreting pituitary adenomas that lead to characteristic phenotypical changes. Its association with emty sella (ES) has been described and different theories has been given to explain such situation. Moreover, patients with acromegaly often develops different pathologies of the thyroid gland, however, the occurrence of grave’s disease (GD) is quite a rare situation. Here we report a case of a pati...

ea0070ep324 | Pituitary and Neuroendocrinology | ECE2020

Significant weight loss as an unusual presentation of empty sella – case report

Ene Cristina

Introduction: Unexplained weight loss is a cause for concern; it might indicate an underlying condition, usualy a catabolic state. In empty sella, the progressive loss of pituitary hormone secretion is usually a slow process, with symptoms varying from one person to another and depends on the underlying cause. Usually the weight remain relatively constant or we could have several arguments for weight gain.Case report: A 57 years old man with significant ...

ea0070ep325 | Pituitary and Neuroendocrinology | ECE2020

Screening for developmental neurotoxicity test using 46C cells

Mi Park Seon , Jeong Sunhwa , Lee Jae-Hwan , Jung Eui-Man , Jeung Eui-Bae

Developmental toxicity tests have been made by embryonic stem cell tests at the European Centre for the Validation of Alternative Methods or by embryonic body test in our laboratory. However, no neuronal-specific developmental toxicity test has been made yet. Therefore, this study was carried out using a 46C cell line, mouse embryonic stem cells with an endogenous Sox1-GFP reporter, to exploit the developmental neurotoxicity test. The expression of Sox1, a marker for neural pr...

ea0070ep326 | Pituitary and Neuroendocrinology | ECE2020

Therapeutic difficulties in the management of craniopharyngioma

Bouzid Aicha , Laloui Amina , Meskine Djamila

The craniopharyngioma is a benign tumor, curable but aggressive by its localization involving the vital and visual prognosis of the patients. Treated mainly by surgery associated with radiotherapy which allows high long-term survival but at the expense of significant side effects, it nevertheless poses a problem of therapeutic management. The aim of this study is to illustrate the therapeutic difficulties in the management of craniopharyngiomaPatients an...

ea0070ep327 | Pituitary and Neuroendocrinology | ECE2020

Conservative management of pituitary apoplexy – a case series

Trifanescu Raluca , Niculescu Dan Alexandru , Cristescu Alexandru , Alexandra Smarandoiu Georgiana , Dobre Ramona , Caragheorgheopol Andra , Hortopan Dan , Dumitrașcu Anda , Poiana Catalina

Introduction: Pituitary apoplexy is a rare complication in 2%-12% of pituitary adenomas, due to sudden hemorrhage or infarction. Patients with signs of meningeal irritation, important visual field defects, ocular paresis, decreased unilateral or bilateral visual acuity or altered consciousness are treated by neurosurgical intervention, while patients without these signs could be managed conservatively.Aim: To present a series of 4 cases with pituitary ap...

ea0070ep328 | Pituitary and Neuroendocrinology | ECE2020

Radiation therapy in the management of pituitary adenomas

Bouzid Aicha , Maataoui Abdelmoumen , Harid Abbas , Meskine Djamila

Despite advances in neurosurgical techniques, due to their size and their readily invasive nature, surgical resection of functional or non-functional pituitary macroadenomas is often only partial, justifying the use of any additional treatment (resumption of surgery, radiotherapy, treatment drug).Patients and Methods: 10 patients were included in the study (7 men middle-aged 56 and 3 women middle-aged 48). 4 patients followed for non-functional pituitary...

ea0070ep329 | Pituitary and Neuroendocrinology | ECE2020

A rare tumor at the adult of the hypophysis: Atipic teratoid rabdoid tumor

Sebile Dökmetaș Hatice , Çakır Aslı , Cila Ayșenur , Dökmetaș Meriç , Kılıçlı Fatih

Pituitary adenomas are the most common cause of pituitary lesions. Atypical teratoid rhabdoid tumors are rare aggressive tumors of the central nervous system and are generally seen in children younger than 2 years of age, but also rarely in adults. Only 18 cases have been reported with pituitary involvement to 2018. Median survival in these tumors in adults is 21 months and the cause of death is usually tumor recurrence or leptomeningeal spread. Although surgery, chemotherapy ...

ea0070ep330 | Pituitary and Neuroendocrinology | ECE2020

Panhypopituitarism as first manifestation in metastatic lung cancer

Homentcovschi Corina , Parfeni Ovidiu-Dumitru , Mourid Khadija , Craciun Luciana , Becheanu Gabreil , Spataru Dan , Weltz Luminita , Tudor Ioana

Introduction: Metastases in pituitary gland are extremely rare with a reported prevalence of 1% among all pituitary tumor resections and 1 to 3.6% among post-mortem studies (1). Breast and lung cancer are the most common sites of primary tumor that have been reported to metastasize in pituitary gland and about 7% of all metastases are symptomatic (2.3).Case report: A 62-year-old male with a 40-pack-year smoking history and no previous medical conditions ...

ea0070ep331 | Pituitary and Neuroendocrinology | ECE2020

GH deficiency in children with sickle cell anemia: About a case

Dorraelguiche Dorra , Jemel Manel , Anis Grassa , Kandara Hajer , Kammoun Ines

Introduction: Growth retardation in sickle cell children is common and multifactorial. Recent evidence suggests damage to the somatotropic axis. We report the case of a patient followed for homozygous sickle cell anemia and in whom we discover an associated GH deficiency.Observation: It is a 13 year old child followed for homozygous sickle cell anemia, splenectomized for 2 years, not polytransfused. We were sent to the hematology department before a dela...

ea0070ep332 | Pituitary and Neuroendocrinology | ECE2020

Can you predict the recurrence of cushing’s disease after surgery?

Moreno-Moreno Paloma , Camara-Gómez Rosa , Soto-Moreno Alfonso , Fajardo-Montañana Carmen , Luque Raul M , Ángeles Gálvez-Moreno María

Objective: Remission of Cushing’s disease (CD) in the postoperative vary between 55–85%, recurrence of up to 25%. Remission and recurrence rates vary dependent on tumor size and neurosurgical expertise. The objective of this study is to describe whether there are clinical data that help us to predece recurrence of CD after transsphenoidal surgery (TSS).Patients and Methods: Retrospective analysis of patients who underwent as TSS for CD. Varia...

ea0070ep333 | Pituitary and Neuroendocrinology | ECE2020

Pituitary metastasis from lung cancer: uncomon presentation

Anis Grassa , Jemel Manel , Salma Salhi , Kandara Hajer , Kammoun Ines

Background: Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as anterior pituitary deficiency. Although pituitary gland metastasis is rare, it is underestimated, as it is commonly misdiagnosed with pituitary gland adenoma due to the lack of clear r...

ea0070ep334 | Pituitary and Neuroendocrinology | ECE2020

Optimal cumulative dose of cabergoline does not appear to cause fibrotic pulmonary side effects in prolactinoma

Soyluk Selcukbiricik Ozlem , Bingol Zuleyha , Ciftci Dogansen Sema , Kurtulmus Neslihan , Tanrikulu Seher , Eryarman Sema

Introduction: Dopamine agonists (DAs) consisting of cabergoline (CAB) or bromocriptine is the primary therapy in prolactinomas. DAs are also used in Parkinson’s disease and restless leg syndrome with much higher doses. As a result of reports related to doses in these patients, it is known that long term use of DAs can lead to fibrotic syndromes affecting heart and lung. Cardiac valvulopathies are the most common investigated side effects but there are case reports of ple...

ea0070ep335 | Pituitary and Neuroendocrinology | ECE2020

Complications of acromegaly regarding GH concentrations

Amzar Daniela-Georgiana , Melania Balas , Ioana Golu , Mihaela Vlad , Cotoi Laura

Introduction: Acromegaly is a rare disease caused by excess production of growth hormone (GH) and is associated with multiple complications. The prevalence of associated complications and the mortality rate are associated with the duration of exposure to elevated GH levels, early diagnosis being imperative. Diagnosis of acromegaly is most frequently late, after several years of evolution, with the development of cardiovascular, respiratory, metabolic complications. The presenc...

ea0070ep336 | Pituitary and Neuroendocrinology | ECE2020

GH-secreting adenoma in peripubertal period

Amzar Adaniela-Georgiana , Balas Melania , Ioana Golu , Mihaela Vlad , Corina Paul , Cotoi Laura

Introduction: Gigantism represents a rare pathology in children, characterized by growth hormone (GH) excess, before epiphyseal fusion. It associates significant morbidity and decreased life expectancy, in lack of appropriate treatment.Case presentation: O.D., a male patient, 16 years old now, has been followed in our clinic since 2016, being diagnosed with gigantism in Bega Pediatric Clinic, at the age of 12 years 9 months. In 2014, the patient presente...

ea0070ep337 | Pituitary and Neuroendocrinology | ECE2020

The role of contrast-enhanced fast imaging employing steady - state acquisition (FIESTA) for postoperative residual tumor in pituitary adenoma

Kamada Kensaku , Matsuo Takayuki

Preoperative evaluation of pituitary macroadenoma tumor consistency is important for neurosurgery. Thus, we aimed to retrospectively assess the role of contrast-enhanced fast imaging employing steady - state acquisition (FIESTA) in predicting the tumor consistency of pituitary macroadenomas.Objectives: In endoscopic endonasal transsphenoidal surgery of pituitary adenoma, after the removal of the lower component of the tumor, the upper component does not ...

ea0070ep338 | Pituitary and Neuroendocrinology | ECE2020

Intracranial germinoma mimicking a pituitary macroadenoma

Ram Nanik

Background: Intracranial Germ Cell Tumors (GCTs) are thought to originate from error of primordial germ cells migration during embryonic development, manifesting during first and second decade of life and accounts for 3-5% of all intracranial tumors.Methods: We report a case of a 22-year-old patient who presented with progressive visual loss with polyuria and polydipsia, harboring an intracranial germ cell tumor.Case presentation: ...

ea0070ep339 | Pituitary and Neuroendocrinology | ECE2020

A case report: Pituitary granulomatosis with polyangiitis

Sebile Dökmetaș Hatice , Çavușoğlu Güneș , Kılıçlı Fatih , Can Meryem , Dökmetaș Meriç , Cila Ayșenur

Introduction: Granulomatosis with polyangiitis (GPA) is a systemic vasculitis with necrotizing granulomatous inflammation. Any organ including the pituitary can be involved. Here we report a patient diagnosed with GPA who had nearly complete resolution of pituitary mass after cyclophosphamide and methylprednisolone treatment.Case46 year old female patient was admitted to the hospital after being examined by several departments for ...

ea0070ep340 | Pituitary and Neuroendocrinology | ECE2020

The galant trial: a randomised placebo-controlled trial in patients with a gallium-68 dotatate pet positive, clinically non-functioning pituitary macroadenoma on the effect of lanreotide on tumour size

Boertien Tessel M. , Drent M.L. , Booij Jan , Majoie Charles B.L.M. , Stokkel Marcel P.M. , Hoogmoed Jantien , Pereira Alberto M , Biermasz Nienke , Simsek Suat , Veldman Ronald Groote , Tanck Michael W.T. , Fliers Eric , Bisschop Peter H.

Rationale: At present, there is no approved medical treatment for patients with clinically non-functioning pituitary adenoma. A number of open-label studies suggest that treatment with somatostatin analogues may prevent tumour progression in selected patients. In vivo assessment of somatostatin receptor status using 68Ga-DOTATATE PET could help to select patients responsive to treatment.Trial objective: To investigate the effect of the somatosta...

ea0070ep341 | Pituitary and Neuroendocrinology | ECE2020

Long-term-follow-up of patients with gastric bypass surgery secondary to craniopharyngioma associated hypothalamic obesity

Beiglböck Hannes , Fellinger Paul , Ranzenberger-Haider Tamara , Vila Greisa , Luger Anton , Kautzky-Willer Alexandra , Krebs Michael , Wolf Peter

Background: Patients being cured of craniopharyngioma (CP) often suffer from severe hypothalamic obesity due to tumor localization or therapeutic interventions, which has a major impact on increased mortality and reduced quality of life. Gastric bypass surgery (GBS) was suggested to be an effective therapeutic option for weight reduction in those patients. However, long-term changes in body weight and postsurgical complications are unknown.Methods: 5 pat...

ea0070ep342 | Pituitary and Neuroendocrinology | ECE2020

Cushing’s disease with negative mri: an overview of the experience of the endocrinology-diabetology-nutrition department of oujda’s Mohammed-VI university hospital- morocco

Assarrar Imane , Boujtat Khadija , Abir Tahri , Rouf Siham , Latrech Hanane

Introduction: Cushing’s disease is caused by endogenous hypercotisolism, due to the hypersecretion of the adenocorticotropic hormone (ACTH) by an ACTH-secreting pituitary adenoma. However, some patients with Cushing’s disease have no visible adenoma on MRI. The goal of this study is to review the clinical features, diagnosis and medical preparation of patients with Cushing’s disease.Material and Methods: A retrospective study including ...

ea0070ep343 | Pituitary and Neuroendocrinology | ECE2020

Vitamin B12 deficiency associated with multiple endocrine neoplasia type 1: About a case

Cherif Yousra , Derbal Samar , Laamouri Rihab , Rania Ghariani , Dahmene Fatma Ben , Maya Abdallah

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare disease, defined as a tumor developing in at least two endocrine glands including the anterior pituitary gland, the parathyroid glands and the duodeno-pancreatic endocrine tissue. This is an inherited disorder. However, sporadic cases account for 8–14%. We here report a case of MEN1 revealed by vitamin B12 deficiency.Observation: A 37-year-old young woman admitted to our department ...

ea0070ep344 | Pituitary and Neuroendocrinology | ECE2020

Pancreatic neuroendocine tumors and pheochromocytoma in vonhippel lindau disease

Halloul Imen , Othman Wafa Ben , Kacem Njah Maha , Saad Ghada , Benabdelkarim Mzoughi Asma , Maaroufi Amel , Chaieb Molka , Ach Koussay

Introduction: VonHippel Lindau (VHL) disease is an autosomal dominant disorder, responsible of the occurrence of multiple endocrine and non-endocrine lesions. When it comes to this hereditary syndrom., pheochromocytoma and pancreatic neuroendocrine tumors (pNET) require special monitoring and an appropriate treatment, The object of this case report is to highlight the different clinical presentation of the same lesion in the same patient and the difficulties in decisions&#8217...

ea0070ep345 | Pituitary and Neuroendocrinology | ECE2020

Recurrent abscesses as a rare, life-threatening clinical manifestation of Cushing disease

Stogowska Ewa , Łebkowska Agnieszka , Kościuszko Maria , Zieliński Grzegorz , Kowalska Irina , Karczewska-Kupczewska Monika

Introduction: Cushing disease, as a state of chronic hypercortisolism, causes diverse, often nonspecific symptoms, possibly delaying the proper diagnosis.Case report: A 59-year-old woman with the history of type 2 diabetes mellitus, hypertension, osteoporosis and multiannual history of recurrent hospitalizations because of life-threatening multi-sited soft tissue and muscle abscesses, was admitted to the Department of Internal Medicine and Metabolic Dise...

ea0070ep346 | Pituitary and Neuroendocrinology | ECE2020

The role of Octreotide in the treatment of acromegaly

Lekbello Megi , Husi Gerond , Ylli Agron

Acromegaly is a rare disorder with a high morbidity and mortality rate. The diagnosis is typically prolonged over time due to a slow and hidden development of the disease. Current medical therapy for the treatment of acromegaly involves the administration of somatostatin analogues that effectively suppress excess hormone secretion. The objective of this study was to investigate the efficacy of octreotide therapy in acromegalic. A total of 32 patients have been treated with Oct...

ea0070ep347 | Pituitary and Neuroendocrinology | ECE2020

Behaviour of the long-term clinical and analytical characteristics of a series of cases with hypopituitarism

Añez Roberto , Rivas Alejandra , Carlos Percovich Juan , Atencia Jose , Weber Bettina , Brox Noemí , Miguélez María , Gonzalez Laura , Muñoz Diego , Monereo Susana , García Centeno Rogelio

Aim: To describe the clinical and analytical characteristics of patients with hypopituitarism in the Endocrinology Department.Materials and methods: This was a descriptive, retrospective study with 70 patients diagnosed with hypopituitarism in the Endocrinology Department´s outpatient consultations with a follow-up of up to 44 years. The qualitative variables were expressed in frequencies and the quantitative variables showed a normal distribution e...

ea0070ep348 | Pituitary and Neuroendocrinology | ECE2020

A rare cause of ectopic cushing syndrome: Prostate cancer

Atmaca Murat , Temiz Cansu , Sebile Dökmetaș Hatice , Dökmetaș Meriç , Kiliçli Fatih

Objective: To report a rare cause of ectopic adrenocorticotropic hormone (ACTH) secretion leading to Cushing syndrome.Methods: We describe the clinical presentation and management of a case of Cushing syndrome attributable to ectopic ACTH secretion from small cell cancer of the prostate.Results: In a 74-year-old man developed hypocalemia and heart failure. He was found to have severe hypokalemia (serum potassium, 2.37 mEq/l). Hormo...

ea0070ep349 | Pituitary and Neuroendocrinology | ECE2020

Intravenous dexamethasone suppression test in cushing syndrome diagnosis: Three cases

Ince Urcan , Aydin Cevdet , Yildirim Deryol Hilal , Bestepe Nagihan , Topaloglu Oya , Berker Dilek

Introduction: Dexamethasone Suppression Test (DST) is a useful approach in diagnosis and differential diagnosis of Cushing Syndrome (CS) despite its limitations. One of the major limitations is the difficulty to provide standard suppression dose depending on the variability of gastrointestinal absorption. One solution is for this testing serum Dexamethasone levels or test it with intravenous (iv) Dexamethasone In this case, we examined 3 patients to whom we applied intravenous...

ea0070ep350 | Pituitary and Neuroendocrinology | ECE2020

Case report: the combination of acromegaly, primary hyperparathyroidism and colon cancer

Akdoğan Leyla , Serdar Deniz Muzaffer , Saçikara Muhammed , Nasiroğlu Narin , Ali Tam Abbas , Çuhaci Seyrek Neslihan

Introduction: Acromegaly is a chronic disease caused by excess growth hormone (GH) release from an adenoma caused by somatotroph cells of pituitary gland.In acromegaly, it is known that the risk of thyroid and colon cancer is increased 8 and 4 times, respectively, compared to the normal population.Moderate hypercalcemia, due to vitaminD activation, is seen in acromegaly, but overt hypercalcemia, generally secondary to primary hyperparathyroidism, is rare.Combination of acromeg...

ea0070ep351 | Pituitary and Neuroendocrinology | ECE2020

Cardiovascular risk factors in acromegaly: comparison between successful surgery with medical treatment

Egaña Zunzunegui Nerea , Bilbao Ismene , García Cristina , Aramburu Maite , Agea Leire , Olaizola Izaskun , Rojo Jorge , Yoldi Alfredo , Goena Miguel

Introduction: Acromegaly is an insidious disease caused by chronic GH and IGF-I hypersecretion associated with increased morbidity and mortality, mostly from cardiovascular complications. The aim of this study is to compare cardiovascular risk factors, between patients with medical treatment vs cured.Materials and methods: This is a retrospective study of 37 acromegalic patients, 21 well controlled with medical treatment (IGF-I within the normal range fo...

ea0070ep352 | Pituitary and Neuroendocrinology | ECE2020

Hypercortisolism in a patient with previous medullary thyroid carcinoma–is it paraneoplastic or co-existent cushing’s disease?

Carmen Giuca Diandra , Varlan Delia-Maria , Alexandra Smarandoiu Georgiana , Hortopan Dan , Caragheorgheopol Andra , Terzea Dana , Baciu Ionela , Trifanescu Raluca , Poiana Catalina

Introduction: Medullary thyroid carcinoma (MTC) accounts for 3-9% of all thyroid cancers and only 0.7% develop paraneoplastic Cushing’s syndrome. However, incidence of endogenous Cushing’s syndrome is also low (1–3/million population/year), with a female preponderance, pituitary mediated ACTH production being responsible for up to 80% of these cases.Aim: To present the difficulties in the differential diagnosis of ACTH dependent hyperco...

ea0070ep353 | Pituitary and Neuroendocrinology | ECE2020

Diagnosis of panhypopituitarism in adulthood - diagnostic and therapeutic challenges

Celia Lasca Livia , Lozovanu Vera , Kiraly Antonia , Georgescu Carmen , Alina Silaghi Cristina

Introduction: Combined pituitary hormone deficiency (CPHD) is characterized by impaired production of pituitary hormones. A possible cause are PROP-1 mutations (prophet of Pit-1 protein). It plays an essential role in the evolution of pituitary cells secreting GH, TSH, LH, FSH, prolactin; some patients may develop late ACTH deficiency. PROP 1 gene mutation is manifested with variable degrees of phenotype-genotype correlation, with growth failure as the first sign detected in e...

ea0070ep354 | Pituitary and Neuroendocrinology | ECE2020

Crooke’s cell adenoma and cushing disease: A severe case report

Vasques Miguel , Matos Lurdes , Sagarribay Amets , Pontinha Carlos , Mafra Manuela , Cerqueira Luís , Agapito Ana

Introduction: Cushing’s disease (CD) is a potentially fatal disease caused by corticotrophic adenoma of the pituitary gland. Crooke Cell Adenomas (CCA) are a rare variant characterized by cytoplasmic ring deposits of cytokeratin filaments. They are usually aggressive macroadenomas with a higher rate of recurrence and malignancy.Clinical case: A 36 year old man, with 34 kg weight gain and uncontrolled hypertension for 4 years presented at the Emerge...

ea0070ep355 | Pituitary and Neuroendocrinology | ECE2020

Craniopharyngiomas: experience of the endocrinology department EPH bologhine west of algiers

Bouzid Aicha , Gasri Salah , Laloui Amina , Meskine Djamila

Craniopharyngioma is a slow growing benign epithelial tumor, growing from the pituitary stalk or pituitary gland in the sellar and/or parasellar region. Despite its benignity, the quality of life of patients is most often altered, due to the endocrine, visual and neuro-intellectual sequelae linked to the tumor itself and/or its treatment, as well as a high rate of recurrence. local. Early diagnosis remains the determining factor in prognosis. The objective of this study is to ...

ea0070ep356 | Pituitary and Neuroendocrinology | ECE2020

Panhipopituitarism due to inoperable cavernous sinus meningioma

Andrada Predescu Florina , Mustata Theodor , Alexandru Elena , Sorina Martin Carmen , Simona Fica

Panhypopituitarism refers to decreased production of all of the pituitary hormones of the adenohypophysis with or without deficiency of neurohypophysis function. The development of the disorder is frequently insidious and the manifestations often depend on the etiology of the condition.Case report: In October 2019 a 57-year-old man collapsed in front of the hospital after being discharged from the cardiology clinic. The day before, he had undergone angio...

ea0070ep357 | Pituitary and Neuroendocrinology | ECE2020

Pituitary apoplexy

Bouzid Aicha , Aribi Imane , Meskine Djamila

Introduction: Pituitary apoplexy is a rare and potentially life-threatening endocrine and neurosurgical emergency, most often linked to hemorrhage or necrosis of a pituitary adenoma.Observation: We report the case of a 45 year old patient, with a history of chronic headache, hospitalized in the emergency setting for the management of meningeal syndrome with severe headache associated with vomiting, a significant drop in visual acuity, exophthalmos and pt...

ea0070ep358 | Pituitary and Neuroendocrinology | ECE2020

Unexpected diagnosis of ACTH dependent cushing syndrome in an old patient with hypertension, osteoporosis and newly diagnosed diabetes mellitus

Varlan Delia-Maria , Giuca Diandra , Caragheorgheopol Andra , Acsinte Delia , Grigore Iulia , Trifanescu Raluca , Poiana Catalina

Introduction: Cushing syndrome could be missed initially, especially when the presenting features are common in the general population. Before proceeding to the hormonal tests we have to consider that recent studies have shown that up to 50% of patients with CD have different degrees of altered glucose metabolism, up to 80% of CS patients have hypertension independently of their age and sex and hypercorticism changes bone structure and causes vertebral fractures in approximate...

ea0070ep359 | Pituitary and Neuroendocrinology | ECE2020

Ex juvantibus diagnosis of undifferentiated diffuse connective tissue disease

Daminova Lola , Skosyreva Olga , Sabirov Makhsud , Muminova Sitorakhon

The term “undifferentiated connective tissue disease” (UCTD) represents a stage of disease where clinical symptoms and serological abnormalities suggest autoimmune disease, but they are not sufficient to fulfill the diagnostic criteria of any well-established connective tissue disease (CTD). A 73-year-old man was referred to the 3rd hospital of Tashkent Medical Academy with signs of kidney lesion and the history of treatment at two other medical settings.<p cla...

ea0070ep360 | Pituitary and Neuroendocrinology | ECE2020

Carcinoid crisis after peptide receptor radionuclide therapy in patient with midgut neuroendocrine tumor.

Brodowska-Kania Dorota , Saracyn Marek , Kolodziej Maciej , Kowalski Lukasz , Kaminski Grzegorz

Background: Carcinoid crisis (CC) may rarely occur as a complication of general anesthesia/surgery or peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumor (NET). The incidence of CC as a complication of PRRT is underestimated and comes to 10% of all radioisotope therapies. Progressive organ dysfunction, decrease or increase in blood pressure SBP <80 mmHg or >180 mmHg, unexplained tachyarrhythmia with heart rate >120/ min, bronchoconstr...

ea0070ep361 | Pituitary and Neuroendocrinology | ECE2020

The management of acromegaly: experience of the endocrinology–diabetology department of oujda’s mohammed vi university hospital, morocco

Berrabeh Soumiya , Elmahraoui Ouafae , Bouali Houda , Rouf Siham , Latrech Hanane

Introduction: Acromegaly is a rare disease characterized by somatotropic hypersecretion. The disease is associated with multiple significant comorbidities and increased mortality. The purpose of this study is to describe the epidemiological, clinical, para-clinical and therapeutic features of Acromegaly disease.Patients and Methods: This is a retrospective study including 12 patients with acromegaly in the Endocrinology Diabetology Department of Oujda&#8...

ea0070ep362 | Pituitary and Neuroendocrinology | ECE2020

Management and outcomes of prolactinoma: follow-up of 40 patients

Alikhanian Inga , Grineva Elena , Tsoy Uliana , Belousova Lidiya , Dalmatova Anna , Cherebillo Vladislav , Gussaova Natalia

Introduction: Prolactinomas are the most common pituitary adenomas. Dopamine agonists (DAs) are the treatment of choice for prolactinomas. Patients with prolactinomas normally are treated in ambulatory. In some patients there are challenges in therapy, and they need to be hospitalized.Objective: To study the clinical features and outcomes of in-patients with prolactinoma.Materials and methods: A retrospective analysis of 40 hospita...

ea0070ep363 | Pituitary and Neuroendocrinology | ECE2020

Metastatic neuroendocrine tumor of unknown primary site with associated carcinoid syndrome in a young patient–a case report

Antonia Sima , Iulia Florentina Burcea , Mădălina Cristina Sorohan , Roxana Dușceac , Cătălina Poiană

Background: Neuroendocrine tumors (NETs) are relatively uncommon, accounting for 10 to 14 percent of all neuroendocrine neoplasms. Twelve percent to 22% of patiens are metastatic at presentation. The most frequent primary sites are the gastrointestinal tract (62–67%) and the lung (22–27%).Case presentation: We report the case of a 36-year-old female patient diagnosed with metastatic disease, with liver, lung and lymph nodes metastasis with un...

ea0070ep364 | Pituitary and Neuroendocrinology | ECE2020

Insulinoma localized by Ca-stimulation angiography: A case report

Halmi Sándor , Berta Eszter , Erdei Annamária , Lengyel Inez , Nagy Endre V. , Bodor Miklós

Introduction: Insulinoma is a rare tumor of the beta cells of the pancreas. The clinical manifestation is diverse with hypoglycemia and autonomic neurological symptoms. For diagnosis the Whipple’s triad needs to be present: signs of hypoglycemia, glucose level under 3 mmol/l and the cessation of symptoms after administration of iv. glucose. The fasting test confirms the diagnosis. The most commonly used imaging techniques that may localize the tumor are the abdominal ult...

ea0070ep365 | Pituitary and Neuroendocrinology | ECE2020

Acromegaly in young patients - treatment challenges, case presentation

Cotoi Laura , Melania Balas , Ioana Golu , Mihaela Vlad , Amzar Daniela-Georgiana

Introduction: Acromegaly is a debilitating, indolent disease that develops over several years due to extended exposure to elevated growth hormone (GH) levels. It is most commonly caused by somatotropinomas. It represents a rare pathology with an incidence of 3–14 cases per 1 million inhabitants and a prevalence of 40 to 90 cases per 1 million inhabitants. Pituitary adenomas respresent a challenging disease in young patients. Transphenoidal surgery is the best therapeutic...

ea0070ep366 | Pituitary and Neuroendocrinology | ECE2020

Recurrent cushing’s disease and pregnancy: A case report

Benothman Wafa , Saad Ghada , Halloul Imen , Ben Abdelkrim Asma , Hasni Yosra , Chaeib Molka , Kacem Maha , Maaroufi Amel , Ach Koussay

Introduction: Cushing’s disease (CD) is reported in 60-70% of all patients with Cushing’s syndrome (CS), but occurs only in approximately 33% of the reported CS cases in pregnancy. Nevertheless, despite its rarity, pregnancy in patients with CS can be troublesome because of the risk of maternal-fetal complications.Observation: A 28-year-old female patient was referred to our endocrinology department for a suspected CS with morphological alter...

ea0070ep367 | Pituitary and Neuroendocrinology | ECE2020

Diagnosis of multiple endocrine neoplasia type 1 in a patient with hypercalcemia and hyperprolactinemia

Sebile Dökmetaș Hatice , Yıldırım Ayșegül , Kılıçlı Fatih , Cila Ayșenur

Multiple endocrine neoplasia type 1 is a rare autosomal-dominant disorder. The most common endocrine tumors are parathyroid tumors, which cause hyperparathyroidism and hypercalcemia. Other tumors of MEN 1 include pituitary tumors for example prolactinomas and enteropancreatic tumors such as gastrinomas, insulinomas, VIPomas, carcinoid tumors. We report a case of a 31 year old male with MEN 1 presenting hypercalcemia with complaints of fatigue and weakness. On further questioni...

ea0070ep368 | Pituitary and Neuroendocrinology | ECE2020

ACTH-dependent cushing’s syndrome: an overview of the clinical features, diagnosis and treatment in the endocrinology-diabetology and nutrition department of oujda’s mohammed vi university hospital - morocco

Assarrar Imane , Boujtat Khadija , Abdellaoui Wahiba , Rouf Siham , Latrech Hanane

Introduction: Cushing’s syndrome is a rare condition, resulting from chronic exposure to excessive circulating levels of glucocorticoids. This condition is highly associated with complications such as cardiovascular and metabolic disorders. This study aims to review the clinical characteristics, diagnosis and treatment of patients with ACTH-dependent Cushing’s syndrome.Material and Methods: A descriptive and comparative study carried out in t...

ea0070ep369 | Pituitary and Neuroendocrinology | ECE2020

Family case of multiple endocrine neoplasia type 1 in belarusian population

Lushchyk Maxim , Kuzmenkova Elena , Korolenko Galina , Raduk Dmitri , Danilova Larissa I.

Introduction: Multiple endocrine neoplasia type 1 (MEN-1) is a rare, autosomal dominant inherited disorder, characterized by a high predisposition to develop a wide spectrum of endocrine and nonendocrine tumors, mostly of parathyroids, endocrine pancreas, and anterior pituitary.Methods: Analysis of clinical and laboratory data, family history of multiple endocrine neoplasia.Results: A 19-year-old woman with autoimmune thyroiditis a...

ea0070ep370 | Pituitary and Neuroendocrinology | ECE2020

Latrogenic cushing syndrome owing to topical steroids

Nijat Baș Veysel

Topical steroids are widely used by dermatologists and other physicians for the treatment of skin diseases such as diaper dermatitis. Iatrogenic Cushing syndrome may occur as an undesirable outcome of high-dose glucocorticoids treatments. This may also cause hypothalamus–hypophysis– adrenal axis suppression. While this situation may be caused more frequently with oral and topical glucocorticoid therapy, iatrogenic. Here, we report a 6 month-old boy with Cushing syn...

ea0070ep371 | Pituitary and Neuroendocrinology | ECE2020

ACTH-secreting pituitary macroadenomas about tow cases

Chafai Karima , Oumbiche Hamida , Amadou Coralie , Deburge Anne , Pochat Armelle , Bensbaa Rabah , Penfornis Alfred

Introduction: Cushing’s disease is a rare condition observed in about 8–10% of patients with pituitary tumor. In the majority of cases, corticotroph adenomas are small, intrasellar and less than 10mm in diameter, while macroadenomas occur in 4–10% of the patients. An observation of two clinical cases is reported. The observationCase number 1: a female patient aged 31, hospitalized for suspected Cushing’s dis...

ea0070ep372 | Pituitary and Neuroendocrinology | ECE2020

Pasireotide therapy in a patient with pituitary macroadenoma and asymptomatic acromegaly resistant to first generation somatostatin analogues

Concepción Terroba-Larumbe María , Palacio-Mures Jose Maria , Crespo-Soto Cristina , Ventosa-Viña Marta , Cuellar-Olmedo Luis , Acuña-Garcia Manuel , Anacabe-Goyogana Itziar , Areli Ticona-Spinoza Danay , Maria Delgado-Sanz Jose , Angel Rodriguez Garcia Javier

Introduction: Acromegaly increases morbidity and mortality and should be treated even in the asymptomatic phase. It is almost always caused by a GH-producing pituitary adenoma and although transsphenoidal surgery is the treatment of choice in most cases, in others, primary medical therapy is indicated.Clinical case: A 36-year-old female with a family history of thyroid functional pathology and diagnosed with micronodular goiter was evaluated in February ...

ea0070ep373 | Pituitary and Neuroendocrinology | ECE2020

Pituitary macroadenoma (co-secreting GH and Prolactin)

Qari Faiza

A 16 years old boy referred to neurosurgery due to sellar and suprasellar mass. He had a history of retro orbital headache in the last three years. he noticed increase in his height, enlargement of hands and feet. He had one year history of progressive decrease in vision mainly in the left. He did not enter puberty.Physical examinationsBMI 36 kg/m2 (more than 95 percentile), Tall height 190 (more than 97 percentile), Wei...