ECE2020 Audio ePoster Presentations Reproductive and Developmental Endocrinology (79 abstracts)
Background: In severe obesity, hypogonadism in men and androgen excess in women are frequently observed. Sex hormones play an important role in body composition, glucose and lipid metabolism. Bariatric surgery is the most effective treatment strategy to combat morbid obesity. However, if preoperative gonadal dysfunction impacts weight loss and metabolic improvements after surgery is not known.
Methods: 49 men and 104 women were included in a retrospective analysis. Anthropometric characteristics, glucose and lipid metabolism and androgen concentrations were assessed preoperatively and 17.9 ± 11 or 19.3 ± 12 monthspostoperatively in men and women. Men with and without preoperative hypogonadism (HYPO vs CONmale), as well as women with or without preoperative hyperandrogenemia (HYPER vs CONfemale) were compared.
Results: Inmen preoperative hypogonadism was present in 55%, linked to a higher BMI (HYPO 50 ± 6 kg/m2 vs CONmale44 ± 5 kg/m2, P = 0.001). Bariatric surgery results incomparablechanges in BMI in HYPO and CONmale(–16 ± 6 kg/m2 vs –14 ± 5 kg/m2, P = 0.30) and similar improvements in glucose and lipid metabolism. Weight loss reversed hypogonadism in 93%. In women androgen excess was present in 22%, independent of preoperative BMI (CONfemale 44 ± 7 kg/m2 vs HYPER45 ± 7 kg/m2, P = 0.57). Changes in BMI and metabolic improvements were comparable in HYPER and CONfemale (–15 ± 6 kg/m2 vs –15 ± 5 kg/m2, P = 0.88)after bariatric surgery. Hyperandrogenemia was reversed in 61%.
Conclusions: Despite being frequently observed, hypogonadism in men and androgen excess in women have no impact on postsurgical improvements in body weight, glucose and lipid metabolism. Weight reduction resulted in reversal of hypogonadism in almost all men and of hyperandrogenemia in the majority of women.
05 Sep 2020 - 09 Sep 2020