ECE2020 ePoster Presentations Reproductive and Developmental Endocrinology (37 abstracts)
Diagnostic value of anti mullerian hormone for detecting polycystic ovary syndrome in Tunisian morbidly obese women
Rym Belaid 1 , Ibtissem Oueslati 1 , Hana BelhadjHassen 1 , Bassem Hammami 2 , Seif Boukriba 3 , Meriem Yazidi 1 , Wafa Grira 1 , Fatma Chaker 1 , Habiba Mizouni 3 , Moncef Feki 2 & Melika Chihaoui 1
1La Rabta Hospital, Department of Endocrinology, Tunis, Tunisia; 2La Rabta Hospital, Laboratory of Biochemistry, Tunis, Tunisia; 3La Rabta Hospital, Department of Radiology, Tunis, Tunisia
Introduction: The level of anti-Mullerian hormone (AMH) is considered by several authors as a marker of polycystic ovary syndrome (PCOS). However, data are lacking regarding the real role of AMH and its cut-off value for predicting the existence of PCOS in women with morbid obesity.
The aim of this study was to analyze the performance of the AMH assay in the diagnosis of PCOS in women with morbid obesity.
Patients and Methods: We conducted a cross-sectional study including 50 women of reproductive age with morbid obesity. Each patient underwent a clinical examination, biological and hormonal assays and an ovarian ultrasound between the third and fifth day of the menstrual cycle. PCOS was diagnosed according to the Rotterdam criteria.
Results: Participants had an average age of 34.2 ± 7.5 years. PCOS was diagnosed in 20 women (40%). No statistical differences were found between women with and without PCOS regarding age and anthropometric parameters. The mean AMH level was significantly higher in women with PCOS (3.4 ± 3.6 ng/ml vs 1.3 ± 1.2 ng/ml, P = 0.01). It was positively correlated with the Ferriman and Gallwey score (r = 0.49, P = 0.01), total testosterone levels (r = 0.52, P < 10-3) and the LH/FSH ratio (r = 0.29, P = 0.04). Furthermore, AMH level was not correlated with anthropometric parameters, nor the HOMA index, nor the volume of the ovaries nor the number of antral follicles. The area under the ROC curve of AMH in the diagnosis of PCOS was 0.71 ± 0.07, P = 0.01. An AMH level ≥ 5 ng/ml had a sensitivity of 20% and a specificity of 100%. In contrast, an AMH level ≥ 1 ng/ml was significantly associated with PCOS with an Odds Ratio of 4.9 (P = 0.02).
Conclusion: Our results showed an association between PCOS and AMH level in women with morbid obesity. However, specific thresholds for this population must be determined in order to improve the sensitivity and specificity of this hormonal marker.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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