ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2020) 70 EP456 | DOI: 10.1530/endoabs.70.EP456

Anxiety disorders in patients with autoimmune thyroiditis

Iuliia Onofriichuk1 & Maksym Prystupiuk2

1Kyiv City Clinical Hospital #4, Kyiv, Ukraine; 2Bogomolets NMU, Kyiv, Ukraine

To date, up to 35% of the young population (25–60 years) in developed countries are subject to anxiety disorders. The use of anti-anxiety agents in clinical practice does not always lead to a lasting effect. The study included patients who initially consulted a neurologist or psychotherapist. With panic attacks. On the Anxiety and Depression Rating Scale (HADS), all patients received 11 points or more. The use of anti-anxiety drugs gave a short-term effect with subsequent deterioration. The study group included 76 patients with anxiety disorders, men-29 (age 33.9 years), women-47 (age 31.7 years). The whole patient an ultrasound of the thyroid gland; to assess the state of thyroid function, the levels of thyroid-stimulating hormone, free T3 and T4 in serum were studied. In all patients, titers of antibodies to tyrnoglobulin and to thyroid peroxidase were determined. According to the results of ultrasound, it was revealed that the total thyroid gland in 55 (72%) patients was within the age norm, in 21 (28%) patients it exceeded the norm by no more than 20%. In 71 (95%) patients, an increase in the intensity of blood flow in the gland was recorded. According to laboratory results, 76 (100%) patients had free T3 (2.5–4.3 pg/ml) and free T4 (0.93–1.7 ng/dl), which is an indicator of the norm. The level of TSH in 44 (58%) patients was within the normal range (0.4–4.0 µMU/ml) and in 32 (42%) it was within the range of 4.1–6.5 µMU/ml. Tiroglobulin was normal in all patients. All patients had anti-TPO (35–1000 IU/ml). Patients with increased blood flow in the gland, but with normal TSH, 39 (44%) people were prescribed NSAID (ibuprofen 200 mg) twice a day for 14 days. NSAID (ibuprofen 200 mg) twice a day for 14 days and thyroxine at a dosage of 25–50 µg were prescribed to patients with increased blood flow in the gland and increased TSH 32 (42%). for 8 weeks. After that, an ultrasound of the thyroid gland and laboratory tests were performed. During the control, the blood flow in the gland decreased in 60 (79%) patients. TSH levels normalized in 30 (39%) patients. With the HADS scale in 71 (95%) patients, the anxiety level ranged from 4–8, which is a normal indicator, while patients did not receive anti-anxiety drugs. All patients with anxiety disorders need to check the function of the thyroid gland, since its disorders can lead to psycho-emotional disorders.

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