Searchable abstracts of presentations at key conferences in endocrinology
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22nd European Congress of Endocrinology

05 Sep 2020 - 09 Sep 2020

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Europe's leading endocrinology congress showcasing the very best in the study and treatment of endocrine disorders.

ea0070ep411 | Thyroid | ECE2020

Severe hypothyroidism causing acute ileus and polyserositis

Kondrotiene Aiste , Jacinavicius Arturas , Barsiene Lina , Verkauskiene Rasa , Zilaitiene Birute

Introduction: Hypothyroidism is associated with a spectrum of symptoms affecting almost all bodily functions. We present a case of severe hypothyroidism with multiple body cavity effusions, volvulus of sigma creating ileus.Case report: A 70 year old female was admitted to emergency department with dyspnea, and acute abdominal pain. Physical examination was notable for anasarca, abdominal fluid wave, lower extremity pitting edema, hypotension. She did not...

ea0070ep412 | Thyroid | ECE2020

Late-onset endocrine opthalmopathy due to activation of occult Graves’ disease in a patient with toxic adenoma treated with radioiodine (Marine-Lenhart syndrome)

Askitis Dimitrios , Zissimopoulos Athanasios

Introduction: Hyperfunctioning thyroid nodules (toxic adenomas) comprise one of the most common causes of hyperthyroidism and are usually treated with therapeutic radioiodine administration (RAI). Coexistence of such nodules with Graves’ disease (GD) is a rare disorder (Marine-Lenhart syndrome) with a reported prevalence of approximately 2.7–4.1% in GD patients. We present a rare variant of this condition, featuring the case of a patient with hyperfunctioning nodul...

ea0070ep413 | Thyroid | ECE2020

Treating TSH or patient? A case of misleading TSH in a young patient

Mammadov Emin , Bercu Cristian

Background: Primary hypothyroidism diagnosis is mainly based on the TSH (thyroid-stimulating hormone) and free thyroxine (T4) levels. Following treatment initiation, the main lab test used for dose adjustment is TSH. However, there could be potential issues with TSH measurement.Case report: A young lady, 36, presented to our clinic in January 2019, being treated with Levothyroxine 175 mg daily, and having clinical signs and symptoms of thyrotoxicosis: ta...

ea0070ep414 | Thyroid | ECE2020

Myxoedema ascites: An unusual situation revealing Hypothyroidism

Mekni Sabrine , Nacef Ibtissem Ben , Rojbi Imen , Mhedhebi Chedi , Mchirgui Nadia , Lakhoua Youssef , Khiari Karima

Introduction: Clinical presentation of hypothyroidism is frequently insidious. Of the many non specific clinical signs of hypothyroidism, ascites is one of the less common manifestations reported and the diagnosis is often made late with this condition. Herein, we present the cases of isolated ascites revealing hypothyroidism in order to drow attention to hypothyroidism as an etiology of an unexplained isolated ascites.Observation: A 61-year-old diabetic...

ea0070ep415 | Thyroid | ECE2020

Iodine status in a group of pregnant women with chronic autoimmune thyroiditis having as provenience perimarine area of Romania

Olesea Scrinic , Seila Ibadula , Corina Delia , Eduard Circo

Objectives: Assessment of the utility of supplementing the iodine intake during pregnancy in women with chronic autoimmune thyroiditis (CAT) coming from the perimarine territory of Romania.Material and method: The study included 28 pregnant women in the first trimester of pregnancy, diagnosed with CAT. The following variables were evaluated: TSH, FT4, ATPO. The iodine status of pregnant women was analyzed by 2 methods: 1 – the value of the urinary ...

ea0070ep416 | Thyroid | ECE2020

Grave’ disease and Systemic lupus erythematosus association

Saafi Wiem , Guiga Ahmed , Mtira Abir , yehia Wissal Ben , Bouker Ahmed , Atig Amira , Gannouchi Neirouz

Introduction: Graves’ disease is an autoimmune disease that affects the thyroid gland and leads to a state of hyperthyroidism. This disease is caused by the production of antibodies that bind to and activate the thyroid-stimulating hormone (TSH) receptor. In some cases, Grave’ disease may be associated with other organ-specific or systemic autoimmune disorders. One of the most frequent multisystemic autoimmune disorders is Systemic lupus erythematosus (SLE). Many s...

ea0070ep417 | Thyroid | ECE2020

Refractory hypothyroidism: What else should be done?

Ozum Nursah , Yay Adnan , Yaman Miray , Ozsari Levent , Deniz Ferhat , Yonem Arif

The treatment of hypothyroidism is straightforward,replacing with orally L-thyroxine(LT4).However,some factors including malabsorption,pancreas and liver disorders,drug interactions,etc.,may impair the absorption of LT4,and cause therapy failures.In these circumstances,high doses of different oral formulae or parenterally given LT4 may be a solution. Here,we present a case of primary hypothyroidism,resistant to high doses of oral LT4 replacement but,responsive parenteral LT4 a...

ea0070ep418 | Thyroid | ECE2020

3-iodothyronamine (T1AM) is taken up and rapidly metabolized in cell culture medium only at low concentration

Saponaro Federica , Borsò Marco , Verlotta Sara , Bandini Lavinia , Saba Alessandro , Ghelardoni Sandra , Zucchi Riccardo

3-iodothyronamine (T1AM) is rapidly catabolized to iodothyroacetic acid after few hours by serum proteins. To avoid a rapid metabolism during any treatment, DMEM devoid of FBS has been used, inducing changes in the cell culture environmental. We evaluated the uptake and the metabolism of different concentrations of T1AM, in presence of supplemented medium, and the presence of 3-iodothyroacetic aldehyde (Ald), a putative intermediate of T1AM catabolism to TA1.<p ...

ea0070ep419 | Thyroid | ECE2020

Subclinical hyperthyroidism as a cause of atrial fibrillation

Athanassiou Lambros , Siarkos Evangelos , Fortis Athanasios , Kalogirou Thomais , Athanassiou Panagiotis , Kostoglou-Athanassiou Ifigenia

Introduction: Subclinical hyperthyroidism is a syndrome with vague clinical symptoms. It may cause tachycardia, loss of weight or no symptoms at all. Subclinical hyperthyroidism may occur in middle age and in the elderly. It may be related to the occurrence of atrial fibrillation. Subclinical hyperthyroidism may be the result of an autonomous goiter, may occur in the course of follow-up of hypothyroidism, as the needs for treatment may vary over time and substantially diminish...

ea0070ep420 | Thyroid | ECE2020

Autoimmunity in thyroid nodules referred for FNAB

Nistor Irina , Oprea Theodor-Eugen , Gabriela Duta Simona , Alice Albu , Sorina Martin Carmen , Sirbu Anca , Gabriela Barbu Carmen , Simona Fica

Introduction: The aim of the study was to evaluate the relevance of autoimmunity in the cytological results for the thyroid nodules referred to FNAB (fine-needle aspiration biopsy).Materials and methods: Our study included 590 patients who underwent FNAC in 615 nodules between December 2015 and January 2019. Besides demographic data and routine endocrine investigations (thyroid hormonal status, presence of autoimmunity, the actual or past use of levothyr...

ea0070ep421 | Thyroid | ECE2020

Screening of thyroid function in pregnant women in Bulgaria

Borissova Anna-Maria , Dakovska Lilia , Michaylova Eugenia , Trifonova Boyana

In Bulgaria there are epidemiological data for the population of 20–80 years for the frequency of thyroid dysfunction – 6.3% hypothyroidism and 3.7% hyperthyroidism (Bulgarian Society of Endocrinology, 2012). So far, there is no national data on the incidence of thyroid disorders in pregnant women, which is a major lack of the health care system and the purpose of this study is to fill this gap.Material and Methods: We studied 547 pregnant Bu...

ea0070ep422 | Thyroid | ECE2020

Ultrasound guided percutaneous laser ablation of thyroid nodules

Bajuk Nataša Bedernjak , Gaberscek Simona , Pirnat Edvard , Zaletel Katja

Background: Thyroid nodule is the most common endocrine disorder with the prevalence of more than 50% in adults. Majority of nodules are small in size and can be detected only by various imaging methods. Thyroid nodules are usually benign, asymptomatic, and do not need treatment. Growing and large symptomatic thyroid nodules are usually treated with thyroidectomy. Novel minimally invasive ablation techniques can be alternative to surgery. Percutaneous laser ablation is causing...

ea0070ep423 | Thyroid | ECE2020

Risk of developing hypothyroidism during pregnancy in women with autoimmune thyroid disease

Ollero M Dolores , Beroiz Ana Iriarte , Munarriz Alcuaz Patricia , Eguilaz Esparza Nerea , Zubiría Gortázar Juan , García Torres Javier

Women with positive thyroid autoimmunity are considered at risk of developing hypothyroidism in pregnancy, so monitoring thyroid function is recommended.Objective: To assess the risk of gestational hypothyroidism in pregnant women with autoimmune thyroid disease and normal thyrotropin (TSH) at the beginning of pregnancy.Methods: Retrospective review of data from pregnant women attended between April 2016 and October 2019. Women wit...

ea0070ep424 | Thyroid | ECE2020

Amiodarone induced thyrotoxicosis

Bystrianska Marianna , Bystriansky Adrian , Wildova Iveta

Background: Amiodarone induced thyrotoxicosis (AIT) is one of the most important and severe complications caused by amiodarone therapy. The multidisciplinary medical cooperation and combined therapeutic strategies are necessary in some cases.Aim: Analysis of patients suffered from AIT with focus on clinical picture, laboratory findings and possible therapeutic options.Methods and results: We performed retrospective analysis of 35 c...

ea0070ep425 | Thyroid | ECE2020

Upregulation of HLA class I and antiviral immune responses in graves’ disease

Weider Therese , Richardson Sarah , Morgan Noel G. , Paulsen Trond H. , Dahl-Jørgensen Knut , Hammerstad Sara S.

Background: Graves’ disease (GD) is a common autoimmune disease of unknown origin. Evidence of an association between autoimmune thyroid diseases and viral infections is, however, emerging. Human leukocyte antigen (HLA) class I presents both virally and self-derived antigens to circulating immune cells and plays a crucial role in the defense against viral infections. This study aimed to investigate the presence of enterovirus and HLA class I expression in a large GD coho...

ea0070ep426 | Thyroid | ECE2020

A rare case of isolated central hypothyroidism with thyroxine malabsorption

Badshah Amit , Khan Irfan , Singhal Parag

Introduction: Hypothyroidism remains a global problem with prevalence of 1–2% in iodine replete areas of the world. Primary or Autoimmune Hypothyroidism remains the most common type of hypothyroidism worldwide. Central (secondary) hypothyroidism (CH) because of pituitary/hypothalamic disorders is a rare cause of hypothyroidism with reported prevalence of 1:20.000 to 1:80.000 in the general population1. This makes CH about 1000 fold rarer than primary hypothyro...

ea0070ep427 | Thyroid | ECE2020

Thyroid function in pregnancy and atmospheric pollution

Ilias Ioannis , Kakoulidis Ioannis , Togias Stefanos , Stergiotis Stefanos , Michou Aikaterini , Lekkou Anastasia , Mastrodimou Vaso , Pappa Athina , Venaki Evangelia , Koukkou Eftychia

Introduction: Exposure to air pollution and in particular to nitrogen dioxide (NO2) or particulate pollutants less than 2.5 µm (PM2.5) or 10 µm (PM10) in diameter has been linked to thyroid (dys)function in pregnant women. The environmental degradation that has occurred in recent years in the region of Athens led us to a local study of air pollution against thyroid function in pregnant women in Athens. We hypothesized that there may be a dose-effect relati...

ea0070ep428 | Thyroid | ECE2020

The hypothyroid adrenals, transient thyro – adrenal failure – functional or real?

Waddankeri Swaraj

Background: Primary hypothyroidism is one of the most common endocrine disorder, prevalence is in the ranges of 3.8–10.9%. It has been estimated that about 42 million people in India suffer from thyroid diseases. At one end,with easier availability of the assays and better affordability we are now able to diagnose and treat hypothyroidism much earlier. At the other end, we are seeing patients with TSH > 100 at diagnosis, most of them done as a part of routine screeni...

ea0070ep429 | Thyroid | ECE2020

An audit of monitoring of fetus in pregnant women with hyperthyroidism

Quader Monzoor , Nayak Ananth , Masson Geraldine , Usman Saada , Varadhan Lakshminarayanan

Aim: Hyperthyroidism can affect pregnancy outcomes based on activity of the disease, ongoing use of anti-thyroid drugs (ATD) and TSH receptor antibody (TRAB) positivity. The aim of our audit was to analyse the outcomes of fetal monitoring in pregnant women with previous or current history of active hyperthyroidismMethods: The data on all patients with hyperthyroidism and pregnancy over 3 years was collected. The local guidelines recommend TRAB check at 2...

ea0070ep430 | Thyroid | ECE2020

Antithyroperoxydase autoantibody evolution in Hashimoto thyroiditis. Comparison between all re-evaluated patients and those over 10 years observation. January 2020

Peretianu Dan , Cristina Staicu Dana , Oprisan Bogdan

Aim: Most research teams analyze the evolution of patients with Hashimoto thyroiditis (HT) on syndromic basis (e.g., the thyroid function), not on pathogenic basis (the autoantibodies). Thus, most researchers refer to thyroid hormone evolution. In this study we re-analyzed (first in 2018) how evolve the antithyroid autoantibodies. Therefore, we analyzed the antithyroperoxydase antibodies (ATPO) evolutive patterns in patients with HT.Method: 1. ATPO level...

ea0070ep431 | Thyroid | ECE2020

Treatment of benign thyroid nodules in Spain with HIFU. Importance of its size, situation and painful sensation in the results. 18 month follow-up

Pablo Ortiz Remacha Pedro , Vidal Jové Joan

Objectives: Assess the response of benign thyroid nodules to HIFU treatment depending on their volume and localization. Know if the treatment is painful when sedation is not used.Methods: 66 patients with benign thyroid nodules (Bethesda Category II) were treated with HIFU (Echopulse Theraclion). They were grouped in 3 categories by maximal nodule diameter as assessed by echography. Group 1: nodule diameter between 14 and 20 mm; Group 2: between 21 and 3...

ea0070ep432 | Thyroid | ECE2020

Clinical approach after a Bethesda 4 result in a thyroid cytology

Alhambra Expósito Mª Rosa , Barrera-Martín Ana , Rebollo-Román Ángel , Segui-Azpilcueta Pedro , Ángeles Gálvez-Moreno María

Introduction: Thyroid nodules are a very common finding in sonographies (20–75% people). Criteria for clinical management and for cytological diagnosis (-Bethesda system) are well standardized. In spite of this, a gap of knowledge exists as far as management of Bethesda 4 is concerned.Aim: Evaluate the clinical approach of Bethesda 4 (B4) result in a thyroid cytology.Material and Methods: Retrospective study of thyroid nodule...

ea0070ep433 | Thyroid | ECE2020

The effectiveness of the thyroid disease screening program in pregnant women in the slovak republic 2016 compared to 2011

Bielik Matej , Bielik Jan , Kmečova Vladimira , Faktor Marian

Objectives: Thyroid screening in pregnancy has in Slovakia started in 2009 on the basis of a ministerial guidance for diagnosis and therapy of autoimmune diseases of thyroid gland in pregnant women. (source: Vestník MZ SR 39., 2009, pp. 33–39). Its effectiveness was analysed in 2016 and compared with a similar analysis from 2011. The analysis was aimed to verify the implementation rate of the Guidance in practice.Methods: Records from pregnant...

ea0070ep434 | Thyroid | ECE2020

Alteration in thyroid function in a sample of Egyptian female patients with breast cancer receiving adjuvant chemotherapy

Khairy Hany , Saad Mohamed , Mahmoud Laila , Mohamed Walid

Introduction: Chemotherapy, as a systemic therapy, is one of the most effective modalities for cancer treatment. However, the use of chemotherapeutic drugs in patients with breast cancer can lead to thyroid dysfunction. The aim of our work is to determine the influence of adjuvant chemotherapy on thyroid function in female patients with breast cancer after radical mastectomy and before radiotherapy.Materials and methods: Our study was conducted on 40 Egy...

ea0070ep435 | Thyroid | ECE2020

Significance of serum thyroglobulin levels in differentiated thyroid carcinoma patients with distant metastasis

Chang Yen-Hsiang

Background: Distant metastases develop in approximately 5–10% of patients with differentiated thyroid cancer (DTC). Nearly 70% of this subset will become radioiodine refractory (RAI-R) with a poor prognosis. Recently, the multikinase inhibitors (MKIs) showed promising results of treating these patients. It has become crucial to identify RAI-R DTC early. This study was conducted to identify the predictors of RAI-R disease in patients with distant metastasis secondary to d...

ea0070ep436 | Thyroid | ECE2020

Coexistent thyroid and lung cancers resembling flip flop phenomenon

Cavaco Daniela , Simões-Pereira Joana , Leite Valeriano

Introduction: Differentiated thyroid cancer (DTC) prognosis is usually favorable, even when metastatic radioiodine avid disease is present. Radioiodine-refractory disease, usually a sign of higher aggressiveness, can be detected by 18F-FDG-PET/CT. There is a reverse relationship between iodine and FDG accumulation in thyroid cancer lesions, the so-called ‘‘flip-flop’’ phenomenon: when thyroid cancer cells dedifferentiate they tend to lose the...

ea0070ep437 | Thyroid | ECE2020

The learning curve of a new thyroid fine-needle aspiration facility

Alexandru Niculescu Dan , Terzea Dana , Deacu Laura , Poiana Catalina

Fine-needle aspiration (FNA) is the best available technique for preoperative diagnosis of malignancy in thyroid nodules. Although its efficiency has been well described, the learning curve is underreported. We aimed to describe the learning curve of a new FNA facility (endocrinologist/pathologist) in a university based hospital.Methods: In February 2018 a new FNA facility was formed in our hospital comprising an endocrinologist with high experience in t...

ea0070ep438 | Thyroid | ECE2020

Determination of daily iodine consumption amount of people with nodular goitre and relationship with papillary thyroid cancer

Mantar Ferhan , Dökücü Feriha

Objective: There is a risk of malignancy in 5–10 percent of all thyroid nodules. The most common type of thyroid cancer is papillary thyroid cancer (PTC).There are some risk factors has been found in differentiated thyroid cancers like high iodine intake. However, in people with severe or moderate iodine nutritional deficiency (<75 µg/day),an increased risk of thyroid cancer was found 2.6 times higher than those with optimal iodine nutrition (150–299 &#181...

ea0070ep439 | Thyroid | ECE2020

Next generation sequencing of 12 gene panel in differentiated thyroid cancer

Bangaraiahgari Ramesh , Bhargav Panchangam Ramakanth , B Chakrapani , Mayilvaganan Sabaretnam , B Rajesh , Md Rafi , G Rakshith , Akshaya Ramesh D Lakshmi

Introduction: Next-generation sequencing (NGS) in thyroid cancer allows for high-throughput sequencing analysis of various genetic alterations and provides a useful information of tumor biology. NGS Studies on follicular differentiated thyroid cancer have been scanty from Indian subcontinent. In this context, we set out study the prevalence of a genetic panel wide somatic mutations in thyroid cancer.Material and Methods: This prospective study was conduc...

ea0070ep440 | Thyroid | ECE2020

The relationship between clinicopathological factors and recurrence risk of papillary thyroid cancer

Klimaite Raimonda , Dauksiene Dalia , Dauksa Albertas , Sarauskas Valdas , Verkauskiene Rasa , Zilaitiene Birute

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer, accounting for about 80% of all cases of thyroid cancer. 20 – year survival rate is about 90%. However, PTC can be aggressive – up to 30% of the patients have local renewal or systemic spread.Our objective was to evaluated the clinicopathological factors of recurrence in completely resected PTC patients.Methods: A r...

ea0070ep441 | Thyroid | ECE2020

Management difficulties in nodular goiter associated with hypopharynx infiltration – case report

Teodoriu Laura , Magdalena Boboc Andreea , Neagu Georgiana , Ioan Bianca , Rosu Andreea , Christina Ungureanu Maria , Preda Cristina

Introduction: The connection between the pharynx and thyroid is close, so in the situations of concomitance: thyroid nodules and pharynx infiltration is very difficult to establish the primary lesion. Extralaryngeal spread of laryngopharyngeal cancer to the thyroid gland can occur by three pathways: direct extension, lymphatic spread or hematogenous spread. Of these three mechanisms, direct extension is the main mechanism because of the close anatomical relationship of the thy...

ea0070ep442 | Thyroid | ECE2020

Anaplastic thyroid carcinoma: About 6 cases

Masmoudi Mohamed , Hasnaoui Mehdi , El Omri Malika , Thabet Wadii , Mighri Khalifa , Driss Nabil

Introduction: Anaplastic thyroid carcinoma also known as undifferentiated carcinoma is a rare and highly aggressive malignant tumor. It continues to rank as one of the deadliest diseases worldwide and carries a very poor prognosis. It is an aggressive locoregional disease with a high metastatic capacity. There is no agreement with regards to the best treatment.Material and Methods: We reporteded 6 cases of anaplastic thyroid carcinomas treated in the ENT...

ea0070ep443 | Thyroid | ECE2020

Medullary thyroid cancer, papillary thyroid microcarcinoma and Sarcoidosis: a curious association

Benothman Wafa , Salah Amani , Kacem Maha , Maaroufi Amel , Abdelkrim Asma Ben , Saad Ghada , Hasni Yosra , Chaeib Molka , Ach Koussay

Introduction: Medullary thyroid carcinoma (MTC) represents 3–10% of all thyroid cancer. The presence of papillary thyroid microcarcinoma (mPTC) in patients undergoing thyroidectomy for multinodular goiter has been reported as 3–7%.The occurrence of multiple thyroid cancers of different origin in one individual patient is a rare event. We report the case of synchronous papillary and medullary thyroid cancer developed in heterogynous recurrent ...

ea0070ep444 | Thyroid | ECE2020

Can platelet and neutrophil to lymphocyte ratios be used as predictive markers for malignancy in thyroidectomy patients?

Stefana Enache Oana , Martin Sorina , Mustata Theodor , Ion Oana , Chifulescu Andreea , Parfeni Ovidiu , Sirbu Anca , Barbu Carmen , Giulea Cosmin , Miron Adrian , Andrei Florin , Fica Simona

Objectives: In recent studies, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are being investigated as prognostic and diagnostic markers for many malignancies, including thyroid cancer. The aim of our study was to investigate if a relationship exists between NLR and PLR and thyroid cancer.Materials and methods: We retrospectively analysed the files of 953 patients who underwent thyroidectomy in our surgery department between...

ea0070ep445 | Thyroid | ECE2020

Clustering techniques for thyroid nodules malignancy inference in the era of personalized medicine

Giani Andrea , Borges de Souza Patricia , Bartoletti Stefania , Morselli Flavio , Conti Andrea , Chiara Zatelli Maria

Introduction: Thyroid nodules (TN) are common entities usually discovered during a physical exam or by chance with ultrasound (US) procedures performed for reasons different from thyroid check. The majority of nodules are benign, notwithstanding the growing incidence of thyroid cancer (TC), which increases much largely as compared to all other tumours each year and will be, presumably, the most incident malignancy in women after breast cancer. The clinical challenge relies on ...

ea0070ep446 | Thyroid | ECE2020

Prognostic factor of medullary thyroid carcinoma: Experience of one endocrine center

Kvachenyuk Andrey

Based on the medical records of 311 patients with medullary thyroid carcinoma (MTC) treated in the period 1979–2018, using the Kaplan-Meier method, it was found that the sporadic form and male patients are negative predictors of disease. Other is essential for patients with sporadic form of MTC, because sex has no prognostic value in patients with hereditary forms of the disease. The presence of metastases in regional lymph nodes or distant metastases is a poor prognosti...

ea0070ep447 | Thyroid | ECE2020

Mixed medullary-papillary thyroid carcinoma with mixed lymph node metastases

Guerreiro Vanessa , Costa Cláudia , Oliveira Joana , Santos Ana Paula , Farinha Mónica , Freitas Paula , Torres Isabel

Introduction: Medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) are two distinct neoplasms originating from follicular and parafolicular-C cells, respectively. These pathologies have always been considered different from each other in terms of their incidence, their cell origin and their histopathological features. Concurrent occurrence of MTC and PTC in the same patient is an unusual event and its occurrence as true mixed medullary-follicular-derived car...

ea0070ep448 | Thyroid | ECE2020

Relationship between basal thyroglobuline level before radioiodine treatment and therapeutic response in differentiated thyroid carcinoma

Toni García Marta , García Torres Javier , de Carlos Joaquín , Manuel Zubiría Juan , Ernaga Ander , Munarriz Alcuaz Patricia , Pineda Arribas Javier , Anda Emma

Objectives: We studied whether the postoperative serum thyroglobulin (TG) basal levels before treatment with I131 (baseline TG) could be related with the response to treatment. We consider the excellent response as the absence of clinical, biochemical disease (undetectable TG and anti-thyroglobulin antibodies AcTG negative) and/or structural disease.Material and Methods: This is an observational study that includes 100 patients with differentiated thyroi...

ea0070ep449 | Thyroid | ECE2020

Esophageal perforation due to thyroid lymphoma

Anagnostis Panagiotis , Vaitsi Konstantina , Tzelepi Keraso , Kalaitzis Efstratios

Introduction: Primary thyroid lymphoma (PTL) represents about 1–5% of thyroid malignancies and < 2% of extra-nodal lymphoma. The most common subtype is diffuse large B-cell lymphoma (DLBCL) (~ 50% of cases), followed by mucosa-associated lymphoid tissue (MALT) lymphoma, both non-Hodgkin’ lymphomas. sophageal perforation is a very rare complication during the course of PTL, characterized by poor prognosis.Case presentation: A 65-year-...

ea0070ep450 | Thyroid | ECE2020

Total thyroidectomy can still remain the method of choice in some Bethesda III FNAB cases

Lukas Jindrich

Background: Nonivasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and hyalinizing trabecular tumor (HTT) are a rare follicular- derived thyroid neoplasmas with indolent clinical behavior. These tumors are encapsulated or clearly delimited and distinguished by detail using histopathological criteria.Method: Description of two cases of these rarer tumors, classified on FNAB Bethesda III AUS/FLUS in the BSRTC 2017 and diagnosed...

ea0070ep451 | Thyroid | ECE2020

When levothyroxine is not enough- combination therapy with liothyronine

Veríssimo David , Reis de Almeida Luís , Monteiro Manuel , Dias Luís

Introduction: The treatment of central hypothyroidism with a combination of levothyroxine (T4) and liothyronine (T3) is not recommended for most patients since it does not show an advantage over T4L monotherapy. However, in certain patients who remain symptomatic under replacement therapy with T4L and thyroid stimulating hormone (TSH) within the reference values, combined treatment with T4 and T3 can be tested.Clinical case: Male, 39 years old, medical h...

ea0070ep452 | Thyroid | ECE2020

Ectopic thyroid nodules: Unusual localization

Laamouri Rihab , Nacef Ibtissem Ben , Mohamed Sadok Boudaya , Imen Rojbi , Karima Khiari

Introduction: Thyroid ectopy is uncommon pathology. The lingual area is the most frequent localization. The medaistinal localization is rare. We report in this article two cases illustrating this location.1st clinical case66-year-old woman operated on for benign breast cysts consulted for progressive chest pain. The clinical examination was without abnormalities. The standard biological assessment was normal. Cervicothoracic CT sca...

ea0070ep453 | Thyroid | ECE2020

Epidemiological aspects of medullary thyroid cancer as a component of multiple endocrine neoplasia type 2 in the Republic of Belarus

Dydyshka Yuliya , Shepelkevich Alla , Kondratovich Victor , Leonova Tatiana , Portyanko Anna , Subach Alena , Sosedkova Alexandra , Yurenia Alena , Chakhovich Tatsiana , Smirnov Sergey

Multiple endocrine neoplasia type 2 (MEN2) is a hereditary condition with an autosomal dominant type of inheritance. It is evident that MEN2 is characterized by the presence of Medullary Thyroid Cancer (MTC) as a permanent symptom, the combination of which with pheochromocytoma and parathyroid syndrome is referred to as MEN-2A syndrome. The aim of our study was the creation of a database of patients with MTC and analysis of the data.Materials and methods...

ea0070ep454 | Thyroid | ECE2020

Features of the radical treatment of medullary thyroid cancer in the republic of belarus

Dydyshka Yuliya , Shepelkevich Alla , Kondratovich Victor , Leonova Tatiana , Sosedkova Alexandra , Portyanko Anna , Subach Alena , Chakhovich Tatsiana , Smirnov Sergey , Yurenia Alena

The medical and social significance of the Multiple Endocrine Neoplasia type 2 (MEN2) is due to the severity of the manifestations of the disease components, namely the tumor process progression, a high risk of vascular accidents, pathological fractures of the femoral neck/spine, gastrointestinal bleeding, chronic renal failure. Late detection of pathology is associated with high mortality due to medullary thyroid cancer (MTC). Thus, the aim of the study was to establish the c...

ea0070ep455 | Thyroid | ECE2020

Features of thyroid state in patients with type 1 diabetes and chronic kidney disease receiving renal replacement therapy

Sazonava Alena , Mokhort Tatiana , Karlovich Natalia

Aims: Thyroid function changes are common endocrine disturbance among patients with chronic kidney disease (CKD), including those receiving renal replacement therapy (RRT). The purpose of the study was to study the effect of RRT on thyroid function in patients with type 1 diabetes (T1D).Materials and methods: Thyroid hormone examination was performed before and after hemodialysis procedures (HD) in 9 patients with T1D (3 men and 6 women). Mean age was 41...

ea0070ep456 | Thyroid | ECE2020

Anxiety disorders in patients with autoimmune thyroiditis

Onofriichuk Iuliia , Prystupiuk Maksym

To date, up to 35% of the young population (25–60 years) in developed countries are subject to anxiety disorders. The use of anti-anxiety agents in clinical practice does not always lead to a lasting effect. The study included patients who initially consulted a neurologist or psychotherapist. With panic attacks. On the Anxiety and Depression Rating Scale (HADS), all patients received 11 points or more. The use of anti-anxiety drugs gave a short-term effect with subsequen...

ea0070ep457 | Thyroid | ECE2020

The evaluation of hepcidin in patients with graves’ disease

Hernik Aleksandra , Szczepanek-Parulska Ewelina , Filipowicz Dorota , Ruchala Marek

Introduction: Hepcidin is an acute-phase protein and a key regulator of iron homeostasis. Anemia frequently occurs in patients with hyperthyroidism, while hepcidin may be a potential link.Objectives: Prospective evaluation of hepcidin serum concentration and other parameters related to Fe homeostasis in group of hyperthyroid patients in the course of Graves’ disease (GD) at diagnosis and after restoration of euthyroidism.Pati...

ea0070ep458 | Thyroid | ECE2020

Suspicious thyroid nodule in subacute thyroiditis

Fonseca Ricardo , Roque Catarina , Germano Ana , Sousa Raquel , Aldomiro Fernando

Background: Subacute thyroiditis is an inflammatory condition, most likely of viral origin, which typically presents wit low anterior neck pain, fever and transient thyrotoxicosis. Ultrasonography (US) usually shows a diffuse thyroid enlargement with ill-defined hypoechoic areas.Case: A 55-year old women was admitted in the emergency room, with 2 weeks of anterior neck pain, cervical compressive symptoms of dysphagia, fever and palpitations. On physical ...

ea0070ep459 | Thyroid | ECE2020

Variation of parameters of thyroid function during pregnancy

Mladenovic Violeta , Andjelkovic Marija , Gluvic Zoran , Mitrovic Milena

Introduction: The basic characteristics of metabolism in pregnancy are changes from anabolic to catabolic conditions. During early gestation, the fetus is dependent on maternal thyroid hormones that cross the placenta. Thyroid disease in pregnancy is a common clinical problem, at least 2–3% of women have thyroid dysfunction. Pre-conceptual education and appropriate diagnosis and treatment of thyroid dysfunction in early pregnancy are of great importance, with the aim of ...

ea0070ep460 | Thyroid | ECE2020

Volume changes of thyroid gland in Graves’disease after radioactive iodine treatment

Cepkova Jitka

Introduction: The study describes volume changes of thyroid gland in patients with Graves’disease (GD) after radioactive iodine treatment in the University hospital in Hradec Kralove.Patients and Methods: Retrospectively, we analyzed 66 patients with GD (57 women and 9 men, mean age 52 ± 13.4 years). Volume of thyroid gland was measured before and 1 year after application of radioactive iodine.Results: Total decrease of ...

ea0070ep461 | Thyroid | ECE2020

Immunoassay interference on thyroid functions tests during treatment with Nivolumab

Maria Paragliola Rosa , Corsello Andrea , Papi Giampaolo , Melfa Eleonora , Urbani Andrea , Pontecorvi Alfredo , Carrozza Cinzia , Maria Corsello Salvatore

Background: Immune checkpoint inhibitors (ICI), anticancer therapy blocking specific molecules expressed in tumor microenvironment, are associated to several endocrine side effects. In particular, the use of PD-1/PD-L1 inhibitors is related to a higher incidence of thyroid dysfunction. The most frequent form of thyrotoxicosis is a destructive thyroiditis, which can evolve into hypothyroidism.Patient findings:We report the case of an 85 years-old patient,...

ea0070ep462 | Thyroid | ECE2020

Thyroid nodules during connective tissue diseases

Laamouri Rihab , Derbal Samar , Cherif Yousra , Mayssem Jridi , Dahmene Fatma Ben , Maya Abdallah

Introduction: The association of thyroid nodules and connective tissue diseases (CTD) is not uncommon. The purpose of our work was to describe the clinical, biological and ultrasound characteristics of thyroid nodules during CTD.Materials and methods: It was a retrospective study (2015–2019) including records of patients with CTD and thyroid nodule in an internal medicine department at Ben Arous regional hospital. Informations regarding thyroid fun...

ea0070ep463 | Thyroid | ECE2020

Radioiodine therapy outcome in patient with toxicmultinodular goiter with concomitant hereditary hasharon hemoglobinopathy

Dzeytova Dali , SHklyaev Stanislav , Rumyantsev Pavel , Sheremeta Marina , Trukhin Alexey , Cvetaeva Nina , kozhedub Evgenij

Aim/introduction: The main purpose of this work was to describe a clinical case of thyrotoxicosis with concomitant HASHARON hemoglobinopathy scrutinizing whether the latter could hinder radioiodine therapy (RIT).Materials and methods: Patient H., 53 years old, diagnosed with moderate toxic diffuse multinodular goiter. Clinical manifestation of the disease were in summer 2018 (TSH – 0 mIU/ml). Medication with thyrozole (20 mg) was initiated. Thyroto...

ea0070ep464 | Thyroid | ECE2020

Functional and autoimmune implications in a group of patients with chronic autoimmune thyroiditis associating periodontal disease

Razvan Circo , Seila Ibadula , Cristina Gosu , Olesea Scrinic , Eduard Circo

Introduction: Periodontal disease (PD) is a disease with infectious determinism, initiating inflammatory and autoimmune processes, in intricate evolutionary stages, affecting 10% to 60% of adults.Objectives: Between chronic autoimmune thyroiditis (CAT) and PD there are observations regarding pathogenic interconditioning.Material and methodGroup 1 (n = 109 patients) comprised 84 women and 25 men. ...

ea0070ep465 | Thyroid | ECE2020

Down syndrome & metamorphosis of thyroid autoimmunity

Roque Catarina , Ferrinho Cátia , Limbert Clotilde , Raposo Luís , Sequeira Duarte João

Introduction: Patients with Down syndrome are vulnerable to autoimmune thyroid disease and progression from Graves’ disease (GD) to Hashimoto’ thyroiditis or vice-versa may be more frequently seen in this population, specially at a younger age. In the last years questions have been raised regarding the distinction of this metamorphic scenario from a single entity: autoimmune thyroiditis with TRAbs that trigger opposite functional actions.Case...

ea0070ep466 | Thyroid | ECE2020

Quality of life in patients with Graves’ orbitopathy

Boutzios Georgios , Kouvelioti Sofia , Papaoiconomou Eleni , Koukoulioti Eleni , Miliou Myrto , Tzioufas Athanasios

Introduction: Graves’ disease (GD) is an autoimmune thyroiditis frequently associated with development of Graves’ orbitopathy (GO). As a consequence, patients with GO experience impairment of quality of life (QoL) and social function. The aim of our study was to assess quality of life in patients with GO.Methods: This is a single-center observational study in an outpatient clinic of autoimmune endocrinopathies at a Tertiary, General, Universi...

ea0070ep467 | Thyroid | ECE2020

Diagnostic difficulties in patients with large goiter

Belyakov Ivan , Aleksandrov Yuri , Dyakiv Artem

The purpose was to study the possibility of various diagnostic methods in patients with large goiter. In 2016–2018 years 628 people with thyroid diseases was operated. In 69 cases the volume of the thyroid was 100–1200 cm3. The correlation between thyroid volume and age is weak (0.074033), the duration of the disease is high (0.732455). Evaluation of clinical signs was not difficult, but the examination data and symptoms did not give a adequate picture o...

ea0070ep468 | Thyroid | ECE2020

Etiological profile of hypothyroidism in Nepalese patients

Joshi Ansumali , Yonzon Priyadarshini , Tamang Sabeena

Background: Hypothyroidism is a common endocrine disorder. Common causes are autoimmune disease such as Hashimoto’ thyroiditis, surgical removal of the thyroid, drug induced and radioactive iodine (RAI) ablation.Aim: The aim of our study was to determine the etiology of hypothyroidism in Nepalese patients.Method: This is a retrospective study conducted in our opd from May 2015 to April 2019 in which data was collected from th...

ea0070ep469 | Thyroid | ECE2020

Nivolumab induced relapse of graves’ disease: A case report

Evranos Ogmen Berna , Ali Tam Abbas , Aydin Cevdet , Dirikoç Ahmet , Baser Husniye , Ersoy Reyhan , Cakir Bekir

Background: Immune checkpoint inhibitors, including anti-programmed cell death-1 (PD-1) antibodies, have become promising treatments for a variety of advanced malignancies. Nivolumab, an anti–PD-1 monoclonal Ab, is an effective treatment of unresectable metastatic melanoma, non–small cell lung cancer, renal cell carcinoma, head and neck cancer, Hodgkin lymphoma, and gastric cancer. These medicines can cause immune-related adverse events (irAEs), including endocrino...

ea0070ep470 | Thyroid | ECE2020

Thyroid Dysfunction in patients with HIV infection

Kalogeris Nikolaos , Herolidi Eleni , Moustaki Melpomeni , Dermetzoglou Alexandros , Loi Vasilikh , Vakali Eleni , Lioni Athina , Sakka Vissaria , Mangafas Nikolaos , Chini Maria , Vryonidou Andromahi

Background: The incidence of endocrine complications among patients with HIV infection has decreased over the last years owing to widespread administration of combined Antiretroviral Therapy (cART) at early stages of the disease. We conducted a prospective observational study aiming to characterize the effects of cART on thyroid function in a cohort of newly diagnosed treatment-naive male patients.Materials and methods: Male subjects diagnosed with HIV i...

ea0070ep471 | Thyroid | ECE2020

Risk factors in graves’ disease recurrence after treatment with radioactive iodine

Reis Guiomar Joana , Lemos Luís , Moreno Carolina , Catarino Diana , Fadiga Lúcia , Silva Diana , Vieira Inês , Lavrador Mariana , Costa Gracinda , Paiva Isabel

Introduction: Radioactive iodine (131I) therapy is a safe and cost-effective choice in Graves’ disease (GD). Usually only one treatment with 131I is sufficient, however, individual characteristics of the disease can lead to its recurrence. The aim of this study is to determinate the risk factors that influence the recurrence of GD after 131I.Materials and methods: Retrospective cohort study in 528 patients with GD who did <sup...

ea0070ep472 | Thyroid | ECE2020

Aberrant cervical thymus mimicking thyroid on ultrasonography: A case report

Masmoudi Mohamed , El Omri Malika , Hasnaoui Mehdi , Thabet Wadii , Mighri Khalifa , Driss Nabil

Introduction: An abnormally positioned thymus may either be aberrant or ectopic. Aberrant cervical thymus (ACT) is located along the normal pathway of descent of the thymus, with an attachment to mediastinal thymus via thymic tissue or fibrous cord in 50% of the cases. ACT is usually diagnosed within the first and second decade of life, and most lesions are cystic.Case report: We report a case of 9-year-old woman was referred to our hospital for the oper...

ea0070ep473 | Thyroid | ECE2020

Pseudomalabsorption as a cause of persistent hypothyroidism

Kamoun Elyes , Oueslati Ibtissem , Belaid Rym , Yazidi Meriem , Chaker Fatma , Khessairi Nadia , Chihaoui Melika

Introduction: Levothyroxine is the treatment of hypothyroidism, achieving normal thyroid stimulating hormone (TSH) levels. The optimal dose of Levothyroxine may be affected by several factors such as age, gender, body weight, patient’ compliance, some medical disorders and drugs intake. Persistent hypothyroidism secondary to non compliance is rare and represents a diagnostic challenge.The aim of this study was to describe cases with refractory hypo...

ea0070ep474 | Thyroid | ECE2020

Association of the rs12976445 MIR125A polymorphism with the clinical course of Graves’ disease in Russian population

Peikrishvili Natalia , Volkova Anna , Dora Svetlana

Introduction: Graves’ disease (GD) is an autoimmune disorder of the thyroid gland, which is characterisied by a breakdown in immune tolerance. The lymphocytic infiltration of the thyroid leads to production of autioantibodies targeting thyroid stimulating hormone receptor (TSHR). The clinical course of GD varies among patients and it is difficult to predict the relapse risk after antithyroid therapy withdrawal. It is believed that GD occurs due to genetic suspectibility ...

ea0070ep475 | Thyroid | ECE2020

Peculitaries of markers of thyroid homeostasis in patients with liver cirrhosis of non-viral ethiology

Chympoi Krystyna , Pashkovska Nataliia , Olinyk Oksana , Teleki Jana

The aim of this study was to assess thyroid homeostasis in patients with liver cirrhosis (LC) of non-viral etiology and analyze the association between serum thyroid parameters and A/C polymorphism in the deiodinase type 1 (DIO1) gene in these patients.Material and Methods: The study was conducted on 70 subjects: 50 patients with (LC) and 20 healthy controls. The thyroid homeostasis was evaluated by using «thyroid function tests», measurement o...

ea0070ep476 | Thyroid | ECE2020

Inaugural cardiothyreosis

Besrour Chayma , Chadia Zouaoui , Amel Jaidane , Haroun Ouertani

Introduction: Cardiothyreosis or thyrotoxic heart disease is the most dangerous complication of hyperthyroidism. This rare complication can be revealing and occurs mostly to fragile patients ; eldery or individuals with preexisting cardiac troubles.Observation: We report the case of a 59 years old male without medical history, who consulted the emergency for dyspnea and palpitations due to atrial fibrillation ( ACFA ) not well tolerated with both respira...

ea0070ep477 | Thyroid | ECE2020

Thyrotoxicosis and Tuberculosis (TB) related cervical lymphadenopathies: A case report

Almeida Lucia , Sousa Ana , Melo Gustavo , Ramalho Diogo , Correia Sara , Alves Helena , João Oliveira Maria

Introduction: Grave´s disease (GD) is the most prevalent cause of hyperthyroidism, leading to inflammation of the thyroid gland and sometimes to an enlargement of the nearest lymph nodes caused by that same inflammatory process. Peripheral lymphadenopathy of doubtful cause presents a diagnostic dilemma. There are many potential causes: biopsy is sometimes the best way to reach a definitive diagnosis. Tuberculous adenitis is usually regional and mainly affects nodes of the...

ea0070ep478 | Thyroid | ECE2020

Recurrent subacute thyroiditis case of an elderly patient

Hepsen Sema , Ucan Bekir , Akhanli Pinar , Kizilgul Muhammed , Cakal Erman

Introduction: Subacute thyroiditis (SAT) is the inflammatory disease of thyroid gland, which commonly affects middle-aged females. SAT is rarely seen in extreme age groups. Herein, we reported an 82-year-old patient presenting recurrent SAT.Case report: An 82-year-old female patient presented fever, neck pain, weakness, and dizziness. She had hypertension and peripheral vascular disease. She had a 2-week of symptom history and admitted to emergency servi...

ea0070ep479 | Thyroid | ECE2020

Investigation of aggregation disorders before and after levotyroxin therapy in patients with hashimato thyroiditis

Gizem Fener Nanișe , Sebile Dökmetaș Hatice , Kılıçlı Fatih , Çakan Demirel Burçin , Kaya Zeynep

Objective: Thyroid hormones are powerful mediators of numerous physiological and metabolic processes, including blood clotting, and thyroid dysfunction can adversely affect various stages in the coagulation cascade. Mean platelet volume (MPV) is used to measure platelet size and may indicate platelet activity. Studies have reported that increased MPV is associated with atherosclerotic lesions and cardiovascular diseases, and conflicting results have been reported for the relat...

ea0070ep480 | Thyroid | ECE2020

Laboratory and USG thyroid examinations in the period of 2010 to 2017 in the Slovak Republic

Bielik Jan , Spano Pavol , Bielik Matej

Objectives: Between 2010 to 2018, the number of patients with thyroid disease in the Slovak Republic grew by 43.4%. We investigated the development of physical, laboratory, USG thyroid examinations and economic costs over the period 2010–2017.Methods: The study was conducted using data from patient records of the General Health Insurance Company, which registered approximately 3,497,265 policyholders (66.13%) in 2010 and 3,238,500 policyholders (62...

ea0070ep481 | Thyroid | ECE2020

Is there genetic linkage between benign adenoma and papillary cancer of thyroid: A linkage study through braf and ras gene mutation study

Bangaraiahgari Ramesh , Bhargav Panchangam Ramakanth , Bangaraiahgari Rajesh , reddy Banala Rajkiran , Mohammad Rafi

Introduction: The adenoma- carcinoma sequence in thyroid nodules is an enigmatic phenomenon. Genomics is the only definitive modality to resolve this hypothesis. Adenomas and papillary carcinomas tend to have mutations in RAS and highly specific BRAF gene respectively. In this context, we set out study the prevalence of these somatic mutations in surgical tissue samples.Material and Methods: This prospective study was conducted on surgically managed thyr...

ea0070ep482 | Thyroid | ECE2020

Treatment with tyroisine kinase inhibitor in thyroid cancer: A single centre experience

Catarino Diana , Ribeiro Cristina , Saraiva Joana , Melo Miguel , Fadiga Lucia , Silva Diana , Guiomar Joana , Lavrador Mariana , Vieira Inês , Ferreira Sara , Araújo Cátia , Araújo Bárbara , Paiva Isabel

Introduction: Tyrosine kinase inhibitors (TKI) demonstrated clinically significant activity in radio iodine (RAI)-refractory differentiated thyroid cancer (DTC) and in locally recurrent, unresectable and metastatic medullary thyroid cancer (MTC). The natural history of MTC and DCT is quite variable with rates of disease progression ranging from a few months to many years. TKI can be associated with progression-free survival, but is not curative and the side effects may have a ...

ea0070ep483 | Thyroid | ECE2020

Thyroid metastases from clear cell renal carcinoma: Presentation of two unusual cases and literature review

Corina Pop-Radu Cristina

Clear cell renal carcinoma (CCRC) is a tumor with great metastatic capacity, although the presence of metastases in the thyroid gland is very uncommon. Therefore it is important to know the oncological background of the patient and to perform a complete immunohistochemical analysis of the thyroid lesion to obtain a correct diagnosis. Thyroidectomy can be considered in patients with no other metastasis or in those who present compressive symptoms as a palliative measure. We pre...

ea0070ep484 | Thyroid | ECE2020

Clinical presentation and prognosis of patients with medullary thyroid cancer

de Cicco Federica , Modica Roberta , Barba Livia , Bottiglieri Filomena , Minotta Roberto , Faggiano Antongiulio , Colao Annamaria

Medullary thyroid carcinoma (MTC) is a rare type of tumor that originates from parafollicular C-cells and accounts for 3–4% of all malignant thyroid neoplasms. MTC presents as sporadic (75–80%) or inherited tumors (20–25%). Hereditary MTC is part of multiple endocrine neoplasia type 2 (MEN2). Aim of the study was to describe clinical presentation, prognosis and therapy of sporadic MTC patients. Sixty-seven patients (pts) with histologically confirmed MTC refe...

ea0070ep485 | Thyroid | ECE2020

Anaplastic transformation of well differentiated carcinoma of the thyroid gland with muscle metastasis

Mia Klarisse Danga Justiene , Kasala Ruben

Introduction: Anaplastic thyroid carcinoma (ATC) is the most aggressive and invasive histological type of thyroid carcinomas. Frequently, upon diagnosis obstructive symptoms and loco-regional metastasis have already occurred. Presence of distant metastasis in the skeletal muscle in ATC is rare; and there are less than five documented cases reported worldwide.Case: A 68-year-old Filipino Male, presents with two-month history of pain on the right thigh. He...

ea0070ep486 | Thyroid | ECE2020

Clinical and epidemiological characteristics of thyroid papilar carcinoma at jerez hospital during a 3 years period (2017–2019)

Gloria Baena-Nieto Maria , Marquez-Pardo Rosa , García-García-Doncel Lourdes

Introduction: Papillary carcinoma is the most common form of well-differentiated thyroid cancer (80% of the total). In recent years there has been a significant progressive increase in prevalence.Objectives: The aim of the study was to evaluate the clinical characteristics of the newly diagnosed papillary thyroid carcinoma at the Sanitary Area of Jerez, as well as to analyze its incidence in recent years.Material and Methods: An ob...

ea0070ep487 | Thyroid | ECE2020

The association between thyroid anaplastic carcinoma and papilar carcinoma folicular version – longer life expectancy?

Nechita Mirela-Claudia , Tudurean-Olteanu Anca-Georgiana , Dumitru Teodora , Florescu Alexandru , Christina Ungureanu Maria

Introduction: Anaplastic thyroid carcinoma are highly aggressive solid tumors, with a median survival of less than 6 months after diagnosis. They typically occur in patients who are 65 years of age or older. On the other hand, papillary thyroid carcinoma and follicular thyroid carcinoma are generally indolent, with very few progressive cases.Case report: A 64-year-old patient with no significant pathological history, known with goiter for about 40 years ...

ea0070ep488 | Thyroid | ECE2020

Simultaneous papillary and medulary thyroid carcinoma – how to approach?

Martins Diana , Guelho Daniela , Vicente Nuno , Ventura Mara , Vieira Alexandra

Introduction: Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are distinct neoplasms, associated with different histological findings. Their coexistence in the same patient is a rare event, requiring a different clinical approach.Clinical case: A 72-year-old patient with no family history of thyroid disease, underwent total thyroidectomy in February 2019, due to toxic multinodular goitre, with no evidence of postoperative complica...

ea0070ep489 | Thyroid | ECE2020

Thyroglobulin vs imaging in late recurrent metastatic thyroid carcinoma

Ioana Arhire Amalia , Gabriela Barbu Carmen , Theodor Oprea

Introduction: As the incidence of thyroid cancer is increasing, so are the cases of recurrence with RAI refractory metastasis of thyroid differentiated cancer. We present such a caseCase report: A 77-year-old female with a medical history of papillary thyroid carcinoma recurrence 10 years after surgery with successful 3 RAI sessions and normal thyroid cancer markers after treatment until her recurrence a year ago, with TSH unstimulated thyroglobulin of 1...

ea0070ep490 | Thyroid | ECE2020

Solitary fibrous tumour of the thyroid, features of a very rare tumour: A case report

Dumitru Teodora , Hrisa Anamaria , Nechita Mirela-Claudia , Ciobanu Delia , Danila Radu , Ungureanu Maria-Christina

Introduction: Solitary fibrous tumor (SFT) is a sporadic tumor, commonly found in the pleural cavity. It is like a large well-circumscribed mass, arising from mesenchymal tissue, with spindle cells proliferation, arranged in various patterns. SFT of the thyroid is exceptionally rare, with only about 28 cases being reported in the international literaterature.A 34-year-old woman presented in the Department of Endocrinology with the diagnosis of a multinod...

ea0070ep491 | Thyroid | ECE2020

Incidentally discovered thyroid microcarcinomas in patients undergoing thyroid surgery for benign disease

Anda Apiñariz Emma , Ernaga Lorea Ander , Toni García Marta , Munarriz Alcuaz Patricia , Pineda Arribas Javier , Pablo Martínez De Esteban Juan , Eguilaz Esparza Nerea , Irigaray Ana

Objective: Incidentally discovered thyroid microcarcinomas (TMc) are tumors with a maximal diameter ≥1 cm, indetified during a detailed histopathology examination following a thyroidectomy performed for reasons not pertaining to malignancies of the thyroid gland.Methods: We included 1555 patients who underwent a total thyroidectomy for benign disease between January 2005 and December 2018. Patients with post-surgical pathology consistent with thyro...

ea0070ep492 | Thyroid | ECE2020

Clinical profile of patients with solitary thyroid nodules attending tertiary endocrine centre in Kathmandu, Nepal

Joshi Ansumali , Yonzon Priyadarshini , Rai Pavitra

Background: Thyroid nodules are common with annual increasing trends worldwide. 5% to 15% of the thyroid nodules is thyroid cancer. The prevalence of thyroid nodule is 3%–7% prevalence by palpation and 19%–67% by high resolution ultrasound. Thyroid nodules are more prevalent in women and older age group. More than 95% of all thyroid nodules are benign.Aim: The aim of this study is to assess the clinical profile of patients with solitary thyro...

ea0070ep493 | Thyroid | ECE2020

Prevalence of incidentally finding of papillary thyroid cancer among patients with sporadic medullary thyroid cancer

Boutzios Georgios , Tomara Nefeli , Kotsifa Evgenia , Koukoulioti Eleni , Terra Alexis , Kykalos Stylianos , Spartalis Eleftherios , Vagianos Konstantinos , Tsourouflis Gerasimos

Introduction: The coexistence of papillary thyroid cancer (PTC) and medullary TC (MTC) is rare. Previous retrospective studies have shown a prevalence up to 19%. The aim of our study was to assess the prevalence of PTC in patients with sporadic MTC.Methods: This is a single-center retrospective study of an endocrinology outpatient clinic at a Tertiary, General, University Hospital. Patients who had undergone total thyroidectomy with central neck compartm...

ea0070ep494 | Thyroid | ECE2020

Clinical profile of thyroid cancer patients attending a tertiary endocrine center in Nepal

Joshi Ansumali , Yonzon Priyadarshini , Sharma Thuma

Background: Thyroid cancer is the most common malignant disease of the endocrine system. Thyroid cancer represents above 1% of all malignancies. There is a paucity of data on thyroid cancer in Nepalese patients.Aim: The aim of this study is to explore clinical profile of thyroid cancer patients diagnosed and managed in our center.Methods: A total of 70 patients with thyroid cancer were included in the sample from March 2013 to Dece...

ea0070ep495 | Thyroid | ECE2020

Risk stratification of Bethesda III category thyroid nodules: Tertiary centers experience

Alseddeeqi Eiman

Background: AUS/FLUS (atypia/follicular lesion of undetermined significance) carries a malignancy risk reaching up to 50%. Based on the reported malignancy rate in a given population, the clinical practice towards such a category varies. We hereby identify clinical parameters for risk stratification to aid in decision making for either surgical referral or a clinical follow up.Our aim is to calculate the malignancy risk in Bethesda III category and to id...

ea0070ep496 | Thyroid | ECE2020

Thyroid malignancy among patients with thyroid nodules in the united arab emirates: A five-year retrospective tertiary centre analysis

Alseddeeqi Eiman

Objectives: Thyroid malignancy constitutes the sixth common cancer type in the United Arab Emirates (UAE). There are no epidemiological data outlining the prevalence of cancer in thyroid nodules, nor previous analysis of ultra-sonographic features correlating with thyroid malignancy in the UAE. This study aimed to estimate the prevalence of thyroid malignancy in patients with thyroid nodules and to describe the ultra-sonographic characteristics of thyroid nodules harbouring ma...

ea0070ep497 | Thyroid | ECE2020

Mandibular metastasis revealing a vesicular carcinoma of the thyroid: A case report

Bouchenna Amira , Adel Guidoum , Abdelghani Tibouk , Fatma Berkoune , Kablia Samia Ould

Introduction: Oral metastases are exceptional, representing about 1% of cancers of the oral region. The most common primary tumors are the lung in men and the breast in women. Thyroid carcinoma accounts for approximately 3% of all oral metastatic carcinomas.We are reporting a case.Observation: 65-year-old woman, followed for 35 years for a toxic large goiter at the expense of the right lobe under medical treatment, which consults f...

ea0070ep498 | Thyroid | ECE2020

A case of graves disease with hepatic dysfunction, thrombocytopenia and paralysis

Houssein Mehdi , Turan Kubra , Evranos Ogmen Berna , Aydin Cevdet , Ozdemir Didem , Faki Sevgul

Background: Graves’ disease is an autoimmune disease that is characterized by production of excess thyroid hormones by thyroid gland, which is called hyperthyroidism. Generally, clinical presentations of Graves’ disease range from asymptomatic disease to overt symptomatic hyperthyroidism with heat intolerance, tremor, palpitation, weight loss, and increased appetite. Single-cell lineage haematological abnormalities, such as anemia, leukopenia, and thrombocytopenia,...

ea0070ep499 | Thyroid | ECE2020

Endocrinopathies related to immune checkpoint inhibition: A clinical case presentation

Veríssimo David , Jácome de Castro Matilde , Ivo Catarina , Duarte Vitória , Marcelino Mafalda , Jácome de Castro João

Introduction: In the area of Immunotherapy, immunological checkpoints, such as CTLA-4, PD-1 or PD-L1, are membrane proteins involved in the immune response that, when inhibited, cause an increase in T cell activity and a consequent anti-tumor effect. However, this inhibition can also cause adverse effects, including endocrinopathies, such as thyroid dysfunction and hypophysitis.Clinical case: 59-year-old man, diagnosed with lung cancer, treated with nivo...

ea0070ep500 | Thyroid | ECE2020

Is it Graves orbitopathy?

Firme Ricardo , Morato Pedro , Morato Luiza , Morato Julia

Graves’ orbitopathy, is a rare and potentially sight-threatening ocular disease that sometimes occurs in patients with euthyroid or hypothyroid chronic autoimmune thyroiditis. We relate a case of a man with 53 years that have diabetes and hipertension and regular clinical exams with endocrinologist and oftalmologist. He developed a bilateral exoftalmia, larger at right eye, in 3 months of follow up, without another signs of thyrotoxicosis. After 2 years of follow up, the...

ea0070ep501 | Thyroid | ECE2020

Early diagnosis of acromegaly in chronic thyroiditis-case report

Stancu Ana-Maria , Gabriela Marin Alexandra , Beatrice Preda-Ivascu Monalisa , Mihai Daniel , Stancu Cristina , Badiu Corin

Introduction: Acromegaly is characterized by a pituitary adenoma with excess secretion of GH and IGF-1 hormones. More than 90% of the cases are diagnosed as macroadenomas, after 5 to 10 years of clinical manifestation.Case report: We present the case of a 49 years old man with minor thalassemia, hospitalized in endocrinology department for a routine check of chronic autoimmune thyroiditis. A careful anamnesis showed that in the last year the patient was ...

ea0070ep502 | Thyroid | ECE2020

Size does it matter?

Nikookam Yasmin , Grant Bonnie , Lee Yunni , Syed Imran , Pittathankal Antony , Hawkins Anna , Nikookam Khash

Introduction: Thyroid cancer is the most common malignant endocrine tumour and represents 1% of all malignancies. Cancer Research UK in 2015 reported 3528 new cases and 382 deaths with annual incidence of 5.1 and 1.9 per 100,000 women and men respectively. The incidence is increasing globally, mostly due to papillary thyroid cancer.Ultrasound is the preferred examination with recommended U1-U5 grading system +/- fine-needle aspiration cytology (FNAC)...

ea0070ep503 | Thyroid | ECE2020

‘Thank you for giving me my wife back’ – the role of liothyronine (T3) in primary hypothyroidism

Grant Bonnie , Purkayastha Nirupam , Tanday Raj , Hawkins Anna , Enriquez Nancy , William Augustine , Casey Edel , Nikookam Khash

The British Thyroid Association executive committee advised in 2015 that there was insufficient evidence that levothyroxine(T4) and liothyronine(T3) combination therapy was superior to levothyroxine monotherapy, which remains the standard treatment of primary hypothyroidism. It was considered an experimental approach in symptomatic patients on T4 therapy with a TSH level within normal range.We present a 47-year-old lady who had been diagnosed with primar...

ea0070ep504 | Thyroid | ECE2020

The relationship between thyroid function and lipid metabolism – is it so obvious?

Suwala Szymon , Junik Roman

Introduction: Thyrotropic hormone (TSH), triiodothyronine (fT3) and thyroxine (fT4) affect adipocytes and HMG-CoA hepatic reductase, indirectly regulating the body’s lipid metabolism. This mechanism is already known, however the principles of regulating lipid metabolism through thyroid metabolism constitute an important and a desirable element of scientific research in thyreology. Thyrotropic hormone (TSH), triiodothyronine (fT3) and thyroxine (fT4) affect adipocytes and...

ea0070ep505 | Thyroid | ECE2020

Hypothyroidism, a rare complication of nephrotic syndrome: A case report

Asbar Hind , Junior Louzollo-Kimbembe Rolly , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: During nephrotic syndromes, thyroid function abnormalities may be observed. Hypothyroidism due to loss of thyroid hormones or their binding proteins can be seen but remains a rare complication of nephrotic syndrome. We report the case of 22 year old patient admitted for massive proteinura with nephrotic syndrome that was complicated with hypothyroidism.Case report: We report the case of 22 year old patient who presented with generalized ede...

ea0070ep506 | Thyroid | ECE2020

Hashimoto’s tiroiditis, quervain’s disease and a suspicious nodule

Roque Catarina , Cunha Clara , Bello Carlos , Saraiva Catarina , Sequeira Duarte João

Introduction: The Quervain’s disease is an infrequent subacute thyroiditis (ST) that results in granulomatous infiltration of the gland’s parenchyma. Is usually diagnosed clinically based on cervical pain, systemic symptoms, altered thyroid function tests (TFTs) and history of upper respiratory tract infection. It is a benign self-limited condition that may share US features with malignancy which may result in improper therapy, including lobectomy.<p class="abs...

ea0070ep507 | Thyroid | ECE2020

What is responsible for subacute thyroiditis? Virus or immune system: A case report

Geneș Dilek , Pekkolay Zafer , Güven Mehmet , Şimșek Mehmet , Saraçoğlu Hüsna , Kemal Tuzcu Alpaslan

Background: Subacute thyroiditis (SAT) is a transient thyrotoxic state characterized by suppressed TSH and low uptake of iodine 123 on thyroid scanning. SAT is a self limiting, possibly viral and inflammatory thyroid disorder that is usually associated with thyroid pain and systemic symptoms. Many factors can cause SAT. Infections are considered the most common cause. Vaccines can also lead to SAT.Case report: A 46-year-old male with a history of type 1 ...

ea0070ep508 | Thyroid | ECE2020

The place of radioactive iodine remnant ablation in papillary thyroid microcarcinoma

Masmoudi Mohamed , Hasnaoui Mehdi , El Omri Malika , Lahmar Rihab , Mighri Khalifa , Driss Nabil

Introduction: Thyroid papillary microcarcinoma is a subtype of papillary carcinoma that included tumors with less than 10 mm diameter. Its therapeutic management is still a subject of controversy.Material and Methods: We conducted a retrospective study over 20 cases of papillary thyroid microcarcinoma at the ENT department of Tahar Sfar Hospital in Mahdia over 17 years (2000–2017).Results: We report 20 cases of papillary thyr...

ea0070ep509 | Thyroid | ECE2020

Chronic lymphocytic thyroiditis

Hasnaoui Mehdi , Masmoudi Mohamed , Belaid Takwa , Mighri Khalifa

Introduction: Chronic lymphocytic thyroiditis is an autoimmune pathology affecting 5% of the population. Treatment is most often medical based on hormone treatment. Sometimes thyroiditis will be associated with benign or malignant nodular pathologies requiring the use of surgery. The objective of this study is to describe the diagnostic, therapeutic and evolutionary features of this entity.Materials and methods: It is a retrospective study bringing 28 ca...

ea0070ep510 | Thyroid | ECE2020

Case report of a very unusual thyroid nodule

Penso Rona , Crespo Irene , José Dominguez Cañate Juan , Mola Laura , de Grado Teresa , Herraiz Lorea , Elena Mendoza Maria

Background: Branchial cleft cysts account for almost 20 percent of pediatric neck masses. They are usually present in late childhood or early adulthood, when a previously unrecognized cyst becomes infected. First branchial cleft cysts typically appear on the face near the auricle. Second branchial cleft cysts are the most common and they are usually located just inferior to the angle of the mandible and anterior to the sternocleidomastoid muscle. Third branchial cleft cysts ar...

ea0070ep511 | Thyroid | ECE2020

Concurrent central diabetes insipitus and thyroid hormone resistance syndrome

Kuo Sheng-Fong , Huang Bie-Yui

A 47-year-old male farmer presented to our endocrinology clinic in 2001 with progressive polyuria for half a year. He had a past history of left intracranial hemorrhage with right hemiparesis due to traumatic injury in November 1998 but recovered thereafter. He complained of urine output more than 10 000 c.c. per day. Routine urine check with SP. GRAVITY < 1.005 was noted ( Normal range: 1.005–1.030 ). Serum osmolality was 299 mosm/KgH2O (Normal range: 275...

ea0070ep512 | Thyroid | ECE2020

A rare complication of thyrotoxicosis: diabetic ketoacidosis

Condurache Dorina , Shah Dr Vinit

Graves’ disease is the most common cause of hyperthyroidism. It is well established that hyperthyroidism promotes a hypermetabolic state characterized by increased resting energy expenditure, increased lipolysis and gluconeogenesis. We describe a rare complication of thyrotoxicosis in a patient with type II diabetes on insulin, with no previous thyroid history. An 83 year old woman with type 2 diabetes on biphasic insulin presented with symptoms of polyuria, polydipsia a...

ea0070ep513 | Thyroid | ECE2020

Graves’ disease and papillary thyroid cancer: Clinical case

Volkova Natalya , Davidenko Ilya , Dzherieva Irina , Zibarev Alexander , Ganenko Lilia , Reshetnikov Igor , Sorokina Julia , Degtyareva Julia , Brovkina Snezhana

Background: Graves’ disease in combination with thyroid nodules is more common in women. However, more than one in three patients has carcinoma. Unfortunately, thyroid cancer is most frequently detected accidentally after a thyroidectomy for Graves’ disease, despite the wide possibilities of modern diagnostic methods.Clinical case: A 55-year women complained of discomfort in the neck, sweating, irritability, palpitation. From anamnesis: in 20...

ea0070ep514 | Thyroid | ECE2020

Management and evolution of papillary thyroid carcinoma in a patient with acromegaly

Vlad Mihaela , Cornianu Marioara , Balas Melania , Golu Ioana , Amzar Daniela-Georgiana , Varcus Flore

Background: Acromegaly is a chronic rare disease induced by persistent hypersecretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in adult patients. Several studies have associated acromegaly with an increased risk for developing different benign or malignant tumors.Case presentation: A 33-year old female patient was diagnosed with acromegaly due to a large pituitary macroadenoma, in 2009. In the same period, she was also diagnosed wi...

ea0070ep515 | Thyroid | ECE2020

Grave’s disease as a rare cause of pericardial effusion

Ludwine Bifoume Ndong Charlene , Ghizlane El Mghari Sana Rafi , Ansari Nawal El , Akrim Mohamed

Introduction: The auto immune’s diseases are also involved in the heart’s failure. Grave disease(GD) is an autoimmune thyroid disease that often linked by pericarditis. We report a case of an acute pericarditis that was also presumed to be associated with GD.Case report: A 59 years old who 10 pack years smoker. admitted for chest pain and shortness breathstage 3NYHA. At the investigation there was a progessive emaciation of 12 kg within 7 mon...

ea0070ep516 | Thyroid | ECE2020

Treatment of hypothyroidism does not affect whole-body oxidative stress, as measured by biomarkers of RNA and DNA damage

Ryom Riis Kamilla , Larsen Camilla , Winther Kristian H. , Larsen Emil L. , Ellervik Christina , Hegedüs Laszlo , Brix Thomas , Poulsen Henrik E. , Bonnema Steen J.

Background: Hyperthyroidism as well as hypothyroidism have been associated with oxidative stress, caused by an imbalance between pro-oxidants and antioxidants. Oxidative stress may damage the genomic apparatus and other cellular structures. Urinary excretion of 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), respectively, represent global RNA and DNA oxidation, thus reflecting oxidatively generated modification of nucleic acids in...

ea0070ep517 | Thyroid | ECE2020

Frequency of circulating antithyroid antibodies among the patients with thyroid diseases

Urinbaeva Dinara , Shamansurova Zulaykho , Ismailov Said

Background: Increasing of the level of circulating Antithyroid autoantibodies suggested about autoimmune destruction in thyroid gland and not always depends from thyroid status. We aimed to study the frequency of circulating antithyroid autoantibodies (ATAB) in people with the different thyroid diseases.Material and Methods: In 25 people with high level of circulating ATAB blood serum TSH, T3, T4, glucose, ALAT, protein, albumin levels were measured. Thy...

ea0070ep518 | Thyroid | ECE2020

Management of subclinical hyperthyroidism presented by several cases

Velkoska Nakova Valentina , Krstevska Brankica , Pemovska Gordana , Ahmeti Irfan , Milenkovic Tatjana

Subclinical hyperthyroidism (ScHyper) is a condition with suppressed TSH, and normal free T3 and free T4 hormones, affecting 10% of the population. There are two subgroups of patients, the first group with TSH lower than 0.1 U/l, and the second group with mildly suppressed TSH between 0.1 and the lower assay reference limit. The patients from the first group should be treated, but there is no evidence for therapy for the second group of patients.We prese...

ea0070ep519 | Thyroid | ECE2020

The Role of Selenium and Iodine on thyroid status in the first trimester of pregnancy

Upmale Sabine , Veisa Vija , Kalere Ieva , Šķesters Andrejs , Makrecka- Kūka Marina , Strēle Ieva , Dambrova Maija , Konrāde Ilze

Introduction: Pregnant women are at risk for selenium deficiency, which is known to maintain adequate function of immune system and thyroprotective enzymes. Same, iodine is an essential micronutrient for thyroid hormone synthesis and important endocrine regulator of early brain development. Our previous study revealed that 81% of pregnant women in Latvia have insufficient levels of iodine. The aim of the present study was to evaluate iodine and selenium supply during pregnancy...

ea0070ep520 | Thyroid | ECE2020

Magnitude of increase in levothyroxine requirements during pregnancy in women with pregestational hypothyroidism in navarra (Spain)

Munarriz Alcuaz Patricia , Eguilaz Esparza Nerea , Ernaga Ander , Ollero Garcia-Aulló Maria Dolores , Anda Apiñariz Emma , Beroiz Ana Iriarte , Echarri Ana Irigaray , Sainz De Los Terreros Errea Amaya

Introduction: Hypothyroidism during pregnancy has been asociated with adverse maternal and neonatal outcomes. During pregnancy, maternal levothyroxine (LT4) dose requirements increase. The aim of this study is to determine the increase of LT4 doses during pregnancy in pregestational hypothyroid women.Methods: We included 76 hypothyroid pregnant women. We analyzed analytical and clinical characteristics of these patients, as well as the increase of LT4 re...

ea0070ep521 | Thyroid | ECE2020

Radioiodine therapy and Graves’ disease

Lahousssaine Abainou , El Jadi Hamza , Idrissi Ayoub , Elhadri Sanae , Miftah Azelarab , Baizri Hicham

Used for the first time in 1941 in the United States by Hertz and Roberts for the treatment of hyperthyroidism in Grave’s Disease, radioactive active therapy (RAI) has been able to gain its place within the already existing therapeutic arsenal by being efficient, easy to use and minimally invasive. Our work is a retrospective study of 46 patients collected at the Department of Endocrinology, over a period of 7 years and half from January 1, 2011 to June 30, 2018. The pur...

ea0070ep522 | Thyroid | ECE2020

Autoimmune polyglandular syndrome type 3

Besrour Chayma , Nacef Ibtissem Ben , Imen Rojbi , Youssef Lakhoua , Nadia Mchirgui , Karima Khiari

Introduction: Autoimmune polyendocrine syndrome ( APS ) is a rare, inherited disorder, characterized by autoimmune thyroiditis with another organ specific autoimmune disease.ObservationWe report the case of 55 years old woman, descendant of a first degree consanguineous marriage, who presented at the age of 35 a premature ovarian insufficiency and alopecia. Eight months later, she developed a goiter with hyperthyroidism and the dia...

ea0070ep523 | Thyroid | ECE2020

Low TSH level and twin pregnancy. A case report

Kermaj Marjeta , Fureraj Thanas , Hoxha Violeta , Poshi Klodiana , Ylli Dorina , Hyka Besa , Zavalani Sara , Zaimi Irsa , Resuli Klotilda , Shkurti Adela , Ylli Agron

Introduction: Thyroid physiology changes during pregnancy so the use of pregnancy-specific reference ranges for TSH and FT4 in order to adequately diagnose gestational thyroid disease is necessary. According to literature, in twin pregnancy, TSH can be in low levels during first trimester due to a much higher and more sustained peak of hCG (TSH-like activity of human chorionic gonadotropin) but it will be normalized at the end of the second trimester or within 22 weeks. Hypere...

ea0070ep524 | Thyroid | ECE2020

Oncological disease mimicking endocrine pathology – a challenging case report

Kundzina-Steinberga Linda

Introduction: Patient with co existing oncological disease can easily be misunderstood by endocrinological pathology as hypothyroid, both representing similar appearances. The aim of this case report is to stress the importance of multidisciplinary teamwork, meaning of follow up, and increase knowledge about side effects of hormonal therapy which could affect endocrine system.Case report: A patient 55 years old female complaining about weakness, dry skin...

ea0070ep525 | Thyroid | ECE2020

Continuous enteral feeding in a extremely refractory dumping syndrome

Gonzalez Fernandez Mikel , Elena Lopez Alaminos Maria , Almendra Alvarado Rosas Karol , Serrano Urzaiz Leticia , Trincado Pablo , De Diego Garcia Patricia

Introduction: Dumping syndrome is a phenomenon produced by the alteration of the pyloric sphincter. It occurs in 20% of pyloroplasty or distal gastrectomies. The syndrome is attributed to the rapid emptying of the chyme in the intestine. The osmotic gradient attracts fluid to the intestine, and this releases vasoactive hormones, such as serotonin or vasoactive intestinal polypeptide.Case report: We present a 82-year-old woman with gastric intervention in...

ea0070ep526 | Thyroid | ECE2020

Central hypothyroidism secondary to oxcarbazepine therapy in children-a clinical case report

Mirica Alexandra , Mirica Radu , Monica Preda Diana , Loreta Paun Diana

Introduction: The change in thyroid parameters is described in the case of antiepileptic treatment in the pediatric population, due to interferences within the hypothalamo-pituitary-thyroid axis and due to the increase in the rate of hepatic metabolism of thyroid hormones.Case presentation: We present the case of a 10-year-old boy who addressed our outpatient pediatric endocrinology department for endocrine evaluation in the context of weight growth abou...

ea0070ep527 | Thyroid | ECE2020

Thyroid diseases and mastopathy

Vasyhina Irina , Danilova Larisa

Aim: To assess the thyroid and reproductive system status in 222 women with normal menstrual cycles.Material and Methods: Patients were referred for thyroid ultrasonography and concurrent breast ultrasonography. The 160 women were divided into two groups, based on the nature of the thyroid pathology.Results: The 1st group included 90 women with autoimmune thyroiditis (AIT), the median age was 36.00 [25.00; 50.00] years, the 2nd gro...

ea0070ep528 | Thyroid | ECE2020

Thyroid disorder in patients with spondylarthritis

Ali Khaoula Ben , Slouma Maroua , Dhahri Rym , Metoui Leila , Gharsallah Imen , Louzir Bassem

Background: The association between spondylarthritis and thyroid diseases is unclear. Few studies have examined this association and results remain unknown. We aimed to assess the frequency of thyroid disorders among patients with spondylarthritis.Methods: We performed a cross-sectional study including 50 patients with spondyloarthritis (SA) diagnosed according to ASAS criteria. The disease activity was assessed using ASDAS Free Thyroxine(FT4) and thyroi...

ea0070ep529 | Thyroid | ECE2020

Recurrent subacute thyroiditis associated with microscopic polyangiitis (ANCA positive vasculitis)

Lawrence Townsend Adam , Talapatra Indrajit , James Tymms David , Kumar Mohit

A 56 year old lady was investigated by her GP for arthralgia and found to be thyrotoxic (TSH < 0.01 mU/l, free T4 34.8 (10–20 pmol/l), TPO 50 (<35 IU/ml)). She gave a history of anterior uveitis some 20 years earlier. She was commenced on carbimazole and referred to the endocrinology clinic, where her thyroid function rapidly normalised and a biochemical diagnosis of subacute thyroiditis was made. Thyroid pertechnatate scan showed reduced uptake throughout the gl...

ea0070ep530 | Thyroid | ECE2020

Choice of diagnosis of solid form of papillary carcinoma in pathological investigation rather than fine needle aspiration

Tigishvili Lali , Tsomaia Keti , Khachapuridze Khatuna , Kekelidze Nino , Mchedlishvili Giorgi , Mchedlishvili Maya

Thyroid cancer in children at the age of 0–14 year is a rare case and according to 2018 y. sta-tistics, it comprise 4% of total endocrine system cancer. This article describes clinical case of 14 years old boy with the solid form of thyroid carcinoma and the diagnosis was based on the surgical tissue examination. According to planned ultrasound investigation 2 cm nodule was revealed in the left lobe of thyroid gland without involvement in lymph nodules. Blood test of TSH...

ea0070ep531 | Thyroid | ECE2020

Hurtle cell carcinoma: A case report

Abir Meherzi , Kdissa Amal , Mouna Belakhdher , Khalifa Mouna , Ghamam Monia , Wassim Kermani , Mohamed Abdelkefi

Background: Hürthle cell carcinoma or oncocytic carcinoma of the thyroid gland is an unusual and relatively rare type of differentiated thyroid cancer. It accounts for only about 3–10% of all differentiated thyroid cancers. Its diagnosis as well as its management remains a subject of controversies.Aim: The purpose of this paper is to describe clinical presentation as well as the difficulties we can affront within the diagnosis and the treatmen...

ea0070ep532 | Thyroid | ECE2020

The functional state of the parathyroid glands among patients with autoimmune thyroiditis with the presence of calcifications in the thyroid glands

Badalyan Emma , Badalyan Maria

Thirty five patients (33 women, 2 men) age 26–67 who had calcifications in the thyroid gland in a result of ultrasound examination, the levels of parathyroid hormone, vitamin D and microliters (Ca++, Mg++ and Phosphorus) have been determined as well. The level of 25(OH) in the studied groups were significantly reduced and was within the following range; 14 ± 7 ng/ml. Twenty five patients had hyperparathyroidism, which indicated ...