Endocrine Abstracts

Introduction: Autoimmune polyglandular syndromes (APS) are affected by a primary lesion of 2 or more peripheral endocrine glands with the development of their insufficiency. Examination of people suffering from a disease, which may be part of combined autoimmune endocrinopathies.

The aim

To study the features of the course APS.

Materials and methods: Patient M., 11 years old with complaints of increased blood glucose, general weakness, thirst, dry mouth, dry skin, pain in the upper abdomen. Nausea, disturbed stool. Headache and dizziness. From the anamnesis: sick with type 1 diabetes for 5 years. Receives insulin therapy: NPX – 9 + 7 IU. Short acting – 3 + 3 + 31U. Laboratory and instrumental methods: GBA, GUA, A1C, ALT, AST, TTH, T4, cortisol, hepatitis B, C and Triglycerides.

Results: During laboratory and instrumental examinations were detected, subclinical hypothyroid and transaminase elevation. The results of laboratory studies: Hb Al c – 11.8, AST – 105 U/l, ALT 84 U/l, T4 free – 1.06 ng/dl, TTH – 7.12 mIU/l. Urinary cortisol 26.1 nmol/l, 26.8 nmol/l in blood.

Conclusion: Based on the data of anamnesis, physical examination, laboratory and instrumental studies, the following diagnosis – autoimmune polyglandular syndrome. In addition to insulin therapy, a cortef has been added to the treatment for chronic adrenal insufficiency, hepatoprotectors to eliminate the symptoms of autoimmune hepatitis.