Endocrine Abstracts

Background: Vitamin D deficiency is a major public health problem in Ukraine. The aim of this cross-sectional study was to study the status of Vitamin D and parathyroid hormone (PTH) level in women of reproductive age in Carpathian region.

Materials and methods: A cross-sectional study was carried on a total of 416 nonpregnant and nonlactating women in the reproductive age group of 19–45 years during summer 2018. Demographic, socioeconomic class, and biochemical parameters for the estimation of serum 25(OH)D and PTH levels in women of reproductive age were studied. Serum 25(OH) D and PTH levels were estimated by chemiluminescent immunoassay (chemiluminescence) and colorimetric assay (Roche Cobas) technique.

Results: The mean age of individuals was 36 ± 8 years. The median values for serum 25(OH) D and PTH level was found to be 17.42 (8–52) ng/ml and 57.2 (27.5–83.1) pg/ml accordingly. Vitamin D level less than 30 ng/ml was detected in 389 (93.5%) of participants. Vitamin D insufficiency was found in 148 persons (38.0%), deficiency – in 241 (62.0%). Significantly higher 25(OH)D level was registered in younger age group (19–34 years) as compared to 35–45 age group. In the univariable model, vitamin D deficiency showed a significant inverse association with age and body mass index. Serum PTH level was in the normal range in 345 (82.9%) of the subjects and high level – in 17.1%. Negative correlation between levels of 25(OH)D and PTH (P = 0.02) was revealed.

Conclusions: There is a high prevalence of hypovitaminosis D among women of reproductive age. The risk of the development of osteoporosis and pregnancy-related complications in future is higher in these women.