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Belgian Endocrine Society 2020

Online, Online
11 Nov 2020 - 11 Nov 2020

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BES 2020

Fertility in men with 5-alpha reductase deficiency

ea0071028 | Fertility in men with 5-alpha reductase deficiency | BES2020

Fertility in men with 5-alpha reductase deficiency

Wout Devlies , Elisabet Van Loon , Steven Joniau , Frank Claessens , Leen Antonio , Dirk Vanderschueren

Introduction: 5 Alpha reductase deficiency (5-ARD) is a rare autosomal recessive disorder causing disturbance of sex development. 5 Alpha reductase is an enzyme involved in steroid metabolism, catalyzing testosterone into dihydrotestosterone (DHT), its potent form. 5-ARD therefore results in lower DHT and higher testosterone values. DHT is crucial for the differentiation of the urogenital sinus and genital tubercle into the external genitalia, urethra and prostate, while the v...