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Belgian Endocrine Society 2020

Online, Online
11 Nov 2020 - 11 Nov 2020

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BES 2020

Novel model of sex steroid deficiency in mice to study the physiological effects of delayed and suppressed puberty

ea0071002 | Novel model of sex steroid deficiency in mice to study the physiological effects of delayed and suppressed puberty | BES2020

Novel model of sex steroid deficiency in mice to study the physiological effects of delayed and suppressed puberty

Kim Na Ri , Rougin Khalil , Karel David , Leen Antonio , Dieter Schollaert , Ludo Deboel , HerckErik Van , Nele Wardenier , Martine Cools , Brigitte Decallonne , Frank Claessens , Vanessa Dubois , Dirk Vanderschueren

Background: Sex steroids are critical for skeletal development and maturation during puberty as well as skeletal maintenance during adult life. However, the exact time during puberty when sex steroids have the highest impact as well as the ability of bone to recover from transient sex steroid deficiency is unclear. The latter is highly relevant in the clinical context of delayed puberty, since the impact of a delayed pubertal onset on adult bone health remains elusive. Surgica...