BES2020 BES 2020 Early decline of androgen levels in healthy adult men: an effect of aging per se? A prospective cohort study (1 abstracts)
Early decline of androgen levels in healthy adult men: an effect of aging per se? A prospective cohort study
Banica Thiberiu 1 , Verroken Charlotte 1 , Reyns Tim 2 , Mahmoud Ahmed 1 , T’Sjoen Guy 1 , Fiers Tom 2 , Kaufman Jean-Marc 1 & Lapauw Bruno 1
1Department of Endocrinology, Ghent University Hospital, Ghent, Belgium; 2Department of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium
Background: Investigating longitudinal changes in serum androgen levels in healthy men in relation to (changes in) body composition, lifestyle factors and intercurrent illnesses.
Methods: Longitudinal observational study. 999 healthy men aged 24–46 years of whom 691 were re-evaluated after a mean period of 12 years. Serum SHBG, luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were measured using immuno-assays. Testosterone (T), estradiol (E2), dihydro-testosterone (DHT), androstenedione (Adione) were measured using LC-MS/MS, free T was calculated (cFT). Analyses adjusted for age, (changes in) BMI, lifestyle factors and intercurrent illnesses.
Findings: Baseline age was 34 ± 6 years. Mean BMI increased by 1.19 kg/m², T levels decreased by 14.2% (20.78 nmol/l vs 17.84 nmol/l), cFT by 19.1% (392.14 pmol/l vs 317.33 pmol/l), DHT by 15.6% (1.54 nmol/l vs. 1.30 nmol/l), and Adione by 10.7% (3.72 nmol/l vs 3.32 nmol/l; all P < 0.001). E2 did not change over time (P > 0.05). SHBG increased by 3.0% (39.8 nmol/l vs 41.04 nmol/l), LH by 5.8% (4.57 U/l vs 4.85 U/l) and FSH by 14.7% (4.31 U/l vs. 5.05 U/l) (all P < 0.001). For T, cFT, DHT, Adione and SHBG these longitudinal changes persisted after adjustment for confounders (all P < 0.001).
Funding: This study was supported by a grant from the Fund for Scientific Research – Flanders (FWO-Vlaanderen, Grant #G.0876.11).
Volume 71
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Endocrine Abstracts
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