UKINETS2020 Poster Presentations (1) (16 abstracts)
Well-differentiated Gastroenteropancreatic G3 NET: Findings from a large single centre cohort
Kirstie Lithgow 1 , Hema Venkataraman 2 , Simon Hughes 2 , Husnain Shah 2 , Joanne Kemp-Blake 2 , Suzanne Vickrage 2 , Stacey Smith 2 , Sian Humphries 2 , Mona Elshafie 2 , Philipe Taniere 2 , Salvador Diaz-Cano 2 , Bobby Dasari 2 , Max Almond 2 , Sam Ford 2 , John Ayuk 2 , Shishir Shetty 2 , Tahir Shah2 & Ian Geh 2
1Cumming School of Medicine, Calgary, Canada; 2University of Birmingham NHS Foundation Trust, Birmingham, UK
Purpose: Neuroendocrine neoplasms are known to have heterogeneous biological behavior. G3 neuroendocrine tumours (NET G3) are characterized by well-differentiated morphology and Ki67>20%. The prognosis of this disease is understood to be intermediate between NET G2 and neuroendocrine carcinoma (NEC). Clinical management of NET G3 is challenging due to limited data to inform treatment strategies.
Methods: We describe clinical characteristics, treatment, and outcomes in a large single centre cohort of patients with gastroenteropancreatic NET G3. Data was reviewed from 26 cases managed at our institution from 2012 to 2019.
Results: Most commonly the site of the primary tumour was unknown and majority of cases with identifiable primaries originated in the GI tract. Majority of cases demonstrated somatostatin receptor avidity. Median Ki67 was 30%, and most cases had stage IV disease at diagnosis. Treatment options included surgery, somatostatin analogs (SSA), and chemotherapy with either platinum-based or temozolomide-based regimens. Estimated progression free survival was 4 months following initiation of SSA and 3 months following initiation of chemotherapy. Disease control was observed following treatment in 5/11 patients treated with chemotherapy. Estimated median survival was 19 months; estimated one year survival was 60% and estimated 2 year survival was 13%.
Conclusions: NET G3 is a heterogeneous group of tumours and patients which commonly have advanced disease at presentation. Prognosis is typically poor, though select cases may respond to treatment with SSA and/or chemotherapy. Further study is needed to compare efficacy of different treatment strategies for this disease.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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