Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 72 | UKINETS2020 | Next issue

UKI NETS 18th National Conference

ea0072p1 | (1) | UKINETS2020

Post-operative NETest scores detect residual NET disease and accurately predicts tumor recurrence in R0

Modlin Irvin , Kidd Mark , Oberg Kjell , Falconi Massimo , Luigi Filosso5 Pier , Frilling Andrea , Malczewska Anna , Salem Ronald , Toumpanakis Christos , Laskaratos Faidon-Marios , Partelli Stefano , Roffinella Matteo , Arx Claudia von , Kos-Kudla Beata , Bodei Lisa , Drozdov Ignat , Kitz Alexandra

Introduction: Surgery is the only cure for neuroendocrine tumor (NET) disease. R0 resection is critical for successful tumor resection. Early detection of residual disease is key for optimal management. Both imaging and current biomarkers have intrinsic limitations and are largely ineffective up to 3 months post-surgery. NETest, a multigene blood biomarker test, identifies NETs with >90% accuracy. We hypothesized that surgery would decrease NETest levels and that elevated scor...

ea0072p2 | (1) | UKINETS2020

Survey of challenges in access to diagnostics and treatment for neuroendocrine tumor (NET) patients (SCAN) – UK and Ireland vs global diagnosis of NETs

Bouvier Catherine , McDonnell Mark , Rodien-Louw Christine , Genechten Dirk Van , Leyden Simone , Gellerman Elyse , Dureja Sugandha , Kolarova Teodora

Background: Neuroendocrine tumors are uncommon and complex neoplasms with increasing incidence and prevalence worldwide. SCAN assessed global delivery of healthcare to NET patients.Methods: During Sept-Nov 2019, 2359 NET patients/carers and 436 healthcare professionals (HCPs) from 68 countries completed an online survey, available in 14 languages.Results: 12% NET patients/carers were from United Kingdom (UK) [279/2359], 5% from Ire...

ea0072p3 | (1) | UKINETS2020

Circulating biomarkers to predict progression-free survival in patients with neuroendocrine tumours received 177Lu-DOTATATE

Chen Luohai , Gnanasegaran Gopinath , Mandair Dalvinder , Toumpanakis Christos , Caplin Martyn , Navalkisoor Shaunak

Background: 177Lu-DOTATATE is increasingly used in patients with advanced neuroendocrine tumour (NET). However, few circulating biomarkers are available to predict progression-free survival (PFS) of patients received 177Lu-DOTATATE.Materials and methods: Clinicopathological data and data of baseline circulating biomarkers including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), e...

ea0072p4 | (1) | UKINETS2020

Telotristat in the management of Carcinoid diarrhoea – real world experience of patients from an ENETs centre of excellence in Neuroendocrine tumours.

Khanna Amardeep , Cianci Nicole , Abbas Shah Husnain , Goel Ashish , Jebril Asma , Chauhan Jessica , Pipe Michelle , Shetty Shishir , Weston Christopher , Venkataraman Hema , Smith Stacey , Vickrage Suzanne , Kemp-Blake Joanne , Shah Tahir

Carcinoid syndrome occurs in 20% patients, presenting with flushing, abdominal pain, diarrhoea, and wheeze and can be challenging to manage. The standard of care for carcinoid syndrome is somatostatin analogues (SSAs) with add-on Creon, codeine and loperamide therapy. Nonetheless, half of patients experience debilitating diarrhoea. Telotristat-ethyl is a peripheral tryptophan-hydroxylase inhibitor approved for treatment of diarrhoea, supported by Phase 3 clinical trials but la...

ea0072p5 | (1) | UKINETS2020

Allelic deletion of chromosome 18 is common in intra-abdominal neuroendocrine neoplasms

Gohil Shailesh , Hastings Rob , Shaw Jacqui , Levy Miles

Introduction: Our knowledge of the genomic background of neuroendocrine neoplasms (NENs) is rapidly expanding with more widespread use of sequencing technologies. Although known to be mutationally quiet compared to some other malignancies, many NENs harbour somatic copy number alterations (SCNAs), however the significance of these are unclear.Aims: We sought to identify SCNAs in a cohort of patients with NENs.Methods: Whole exome s...

ea0072p6 | (1) | UKINETS2020

Metachronous neuroendocrine neoplasms in England 2013–2015

White Benjamin E , Genus Tracey , Bouvier Catherine , Ramage John K , Srirajaskanthan Rajaventhan

Introduction: The aetiology of NENs vary; some are sporadic, others familial. An association between index NENs of the mid gut (ileum and colon) with subsequent colorectal primaries has been reported.Aim: We determined to evaluate the relationship between the diagnosis of an index primary malignancy and subsequent diagnosis of NEN.Methods: A population-based retrospective cohort study was under taken for persons with NEN diagnosis ...

ea0072p7 | (1) | UKINETS2020

Carcinoid heart surgery: Review of outcomes from a single large centre

Maclean Rory , Cope Jack , Hota Shweta , Mulholland Nicola , Ramage John , Wendler Olaf , Srirajaskanthan Raj

Introduction: Up to half of patients with carcinoid syndrome develop carcinoid heart disease; this is thought to be mediated by serotonin from disordered tryptophan metabolism. Valve degeneration can lead to right heart failure which drives morbidity and mortality in this patient population. Surgical replacement of affected valves is an effective therapy. Peptide receptor radiotargeted therapy (PRRT) has demonstrated better progression-free survival compared to high dose sando...

ea0072p8 | (1) | UKINETS2020

The prevalence of depression and anxiety among neuroendocrine tumour and general gastroenterology outpatients and the psychometric validity of emotional thermometers

Linton Kirsty , Newton Hannah , Harris Sophie , Lancastle Deborah , John Bev , Vick Tracey , Rees Janice , Hewett Rhys , Khan Mohid , Tahor Tayyeb

Background: Depression and anxiety are frequently associated with functional gastrointestinal disorders (FGID), inducing personal suffering and a decreased quality of life. There is limited data in patients with NETs. Therefore, adequate research identifying the prevalence of these mood disorders among GI patients and NETs are necessary to inform holistic clinical management. Further, due to the nature of hospital clinics being fast-paced, quick and effective screening tools a...

ea0072p9 | (1) | UKINETS2020

Zoom-ing in on natters: Neuroendocrine cancer UK (NCUK) patient support groups during COVID pandemic

Jervis Nikie , Bouvier Catherine

Background: NHS England’s Five Year Forward View refers to peer support as one of the ‘slow burn, high impact’ interventions that should be seen as ‘essential’ to the future of healthcare services, with evidence pointing to benefits in both physical and psychosocial well-being of attendees and potential cost savings to healthcare through improved health condition self-management. However the COVID pandemic has meant that groups cannot currently meet fa...

ea0072p10 | (1) | UKINETS2020

Are outcomes of patients with advanced well-differentiated GEP-NETs on somatostatin analogues similar, irrespective of tracer uptake on 68gallium DOTA SSTR peptide PET CT scans?

Shah Dinakshi , Loveland Oliver , Chander Amarjot , Westwood Tom , Manoharan Prakash , Mansoor Was , Lamarca Angela , Hubner Richard A , Valle Juan W , McNamara Mairead G

Background: Neuroendocrine tumours (NETs) are a rare and heterogeneous group of neoplasms that mainly originate from the gastroenteropancreatic tract (GEP-NETs). The vast majority of NETs tend to overexpress somatostatin receptors (SSTRs), which can be targeted by somatostatin analogues (SSAs). 68Gallium DOTA SSTR peptide positron emission tracer computed tomography (68Ga PET-CT) has emerged as superior to other imaging modalities in identifying SSTRs. Th...

ea0072p11 | (1) | UKINETS2020

The discontinuation of interferon-alfa for the treatment of metastatic NET: A case amongst many of poorer patient outcomes?

Fenn Ricky , Pawsey Alexander , Kapur Gaurav

Interferon alfa-2a was discontinued in June 2020. Here we present a case of an unfortunate patient for whom this change has dramatically impacted the course of her illness. A 64-year-old woman initially presented in 2007 with refractory hypertension and was found to have a phaeochromocytoma which was resected. Metastatic recurrence of her disease in the liver and vertebrae was confirmed by CT/MRI in 2014 following rising catecholamines on monitoring. Her MIBG scan in early 201...

ea0072p12 | (1) | UKINETS2020

A new diagnosis of both a pituitary TSH-oma and a metastaticneuroendocrine tumour

Boharoon Hessa , Ansari Mustafa Al , Sharma Rohini , Bravis Vasiliki , Wernig Florian

We report a new diagnosis of a pituitary TSH-oma together with a metastaticneuroendocrine tumour. A 61 year old man presented with a 3-year history of diarrhoea. His past medical history includes paroxysmal atrial fibrillation, for which he has had an ablation in the past. He takes no regular medications. Initial investigations were suggestive of hyperthyroidism in the context of unusual thyroid function test results (elevated freeT4 and freeT3 with elevated TSH). A pituitary ...

ea0072p13 | (1) | UKINETS2020

Well-differentiated Gastroenteropancreatic G3 NET: Findings from a large single centre cohort

Lithgow Kirstie , Venkataraman Hema , Hughes Simon , Shah Husnain , Kemp-Blake Joanne , Vickrage Suzanne , Smith Stacey , Humphries Sian , Elshafie Mona , Taniere Philipe , Diaz-Cano Salvador , Dasari Bobby , Almond Max , Ford Sam , Ayuk John , Shetty Shishir , Shah Tahir , Geh Ian

Purpose: Neuroendocrine neoplasms are known to have heterogeneous biological behavior. G3 neuroendocrine tumours (NET G3) are characterized by well-differentiated morphology and Ki67>20%. The prognosis of this disease is understood to be intermediate between NET G2 and neuroendocrine carcinoma (NEC). Clinical management of NET G3 is challenging due to limited data to inform treatment strategies.Methods: We describe clinical characteristics, treatment, an...

ea0072p14 | (1) | UKINETS2020

Effective multimodality therapy for a metastatic insulin-secreting pancreatic neuroendocrine tumour (NET): A case report

Ting Jonathan , Kapiris Matthaios , Prachalias Andreas , Velusamy Anand , McGowan Barbara , Carroll Paul , Miquel Rosa , Thillai Kiruthikah , Sarker Debashis

A 23-year-old woman presented in May 2018 with acute left-sided hemiparesis following increasingly frequent episodes of morning drowsiness with associated weight loss. She had no significant past medical history or family history. Brain imaging excluded intracranial pathology. Blood tests during a spontaneous hypoglycaemic episode (1.5 mmol/l) identified significant hyperinsulinaemic hypoglycaemia [insulin 392 pmol/l (18–173) and C-peptide 3913 pmol/l (370–1470)]. MR...

ea0072p15 | (1) | UKINETS2020

Specialist dietetic input in the south wales NET clinic: Patient outcomes

Dowd Charlotte , Powell Catherine , Taylor Rebecca , Cook Kathryn , Blackhouse Jennifer , Khan MS

Background: Nutritional data in NETs is lacking. There are a range of gastrointestinal issues which can be related to the NET, treatment, surgical intervention, or pre-existing diseases1. Many of these can have nutritional consequences or be improved through altering diet with the support of a specialist dietitian.From October 2018, a gastrointestinal specialist dietitian joined the weekly clinic for 12 months. The aim of the service evaluatio...

ea0072p16 | (1) | UKINETS2020

Mixed neuroendocrine-non-endocrine neoplasms (MiNEN): A case of pancreatic acinar – neuroendocrine carcinoma of large cell type

Clifton Emilie , Karampera Christina , Zen Yoh , Thillai Kiruthikah , Sarker Debashis

Background: MiNEN are a rare histological subgroup defined by the association of at least two morphologically different neoplastic components, including one neuroendocrine. The diagnosis and therapeutic management of MiNEN is considered challenging resulting from the rarity and heterogeneity of this subgroup.Case: We present the case of a 68-year-old Caucasian male who attended the emergency department with symptomatic hypoglycaemia on a background of po...