Endocrine Abstracts

The philosophy of my research over the years has been to ask clinically relevant questions which will enhance the practice of decision making in endocrinology, based on scientific assessment of reasonable cohorts. In hitherto unpublished data, we have done work on the assessment of somatostatin responsive headaches in acromegaly and show that they persist over many years, may respond to radiotherapy and may also remain problematic even if acromegaly is cured. We have also look...

Why should we be suspicious of simple explanations in complex problems? The past decades have seen critical advances in understanding the regulation of growth hormone (GH) secretion. I spent many fruitful yers studying the actions of synthetic GH secretagogue, the GH releasing peptide-6 (GHRP-6), on human GH secretion. GHRP-6 mimicked GH releasing hormone (GHRH) but did not bind to GHRH receptor. Powerful joint action (synergism) of GHS/ GHRH was blocked in patients with hypot...