Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2021) 73 AEP60 | DOI: 10.1530/endoabs.73.AEP60

ECE2021 Audio Eposter Presentations Adrenal and Cardiovascular Endocrinology (80 abstracts)

Assessment of glucolipid metabolism in patients with nonfunctional adrenal incidentaloma

Jie Li 1 , Jiaxin Zhang 1 , Guimei Yang 1 , Xintong Hou 1 , Dan Yang 1 , Jing Yang 1 , Yi Zhang 2 & Yunfeng Liu 1


1First Hospital of Shanxi Medical University, Department of Endocrinology, Taiyuan, China; 2Shanxi Medical University, Department of Pharmacology, Taiyuan, China


Backgrounds

The study aimed to explore the characteristics of glucolipid metabolism in patients with nonfunctional adrenal incidentaloma(NFAI). And investigate the relationship between these factors and insulin resistance, islet beta cell function.

Methods

This study enrolled eight patients with nonfunctional adrenal incidentaloma and five healthy controls(HCs). These data were recorded including body measurements, blood biochemical indicators, and the body composition measured by double energy X-ray absorptiometry(DEXA) technique. In addition, blood glucose levels were indicated by flash glucose monitoring system, which better showed blood variability(GV) according to calculating related parameters and analyzinyg several period times including nocturnal, fasting, and postprandial periods. Furthermore, the correlation between glucolipid metabolism and insulin resistance, islet beta cell function were analyzed in the NFAI group.

Results

As compared with HCs, NFAI group showed higher BMI, larger waistline and wasist hip rate(WHR), and lower HDL-c(all P < 0.05). Besides, related indicators with regard to indicators of glucose metabolism and body fat distribution showed no significant difference compared with those of HCs. As for FGMS, all indices indicating GV were not found significant differences compared with those of HCs except lower PT1(the percentage of blood glucose values less than 3.9 mmol/l during the day). Furthermore, the correlation analysis revealed that HbA1c% and FINS were positively correlated with HOMA-IR index, while BMI, neck circumference and lean weight of trunk were negatively correlated with HOMA-β cell function( all P < 0.05).

Conclusion

Compered with HCs, there are abnormalities glucoliqid metabolism and fat distribution changes in patients with NFAI. And fat distribution affect function of islet cells.

Table 1. Parameters with statistical sense in NFAI and HCs
Parameters NFAI HCs P value
BMI(kg/m2) 26.44 ± 1.93 23.20 ± 1.82 0.012
Waistline(cm) 92.89 ± 5.61 75.56 ± 4.57 0.000
Hipline(cm) 102.15(101.28.103.78) 94.50(91.50.102.55) 0.127
Wasist hip rate(WHR) 0.89 ± 0.04 0.79 ± 0.02 0.000
HDL-C(mmol/l) 1.09 ± 0.23 1.63 ± 0.18 0.001
PT1 1.05 ± 1.15 6.76 ± 5.98 0.031
Table 2. The correlation analysis
HOMA-IR
R value P value
HbA1c(%) 0.771 0.025
FINS(mmol/l) 0.684 0.006
HOMA-β
  R value P value
BMI(kg/m2) –0.890 0.003
Neck circumference(cm) –0.767 0.026
Trunk lean mass(g) –0.851 0.007

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.