Adrenal and Cardiovascular Endocrinology

ea0073aep1 | Adrenal and Cardiovascular Endocrinology | ECE2021

Adrenocortical carcinoma treatment in the Netherlands: An analysis from the Netherlands Cancer Registry from 2014 to 2019

Steenaard Rebecca , Rutjens Marieke , Haak Harm R.

BackgroundAdrenocortical carcinoma (ACC) is a rare disease with often poor prognosis. Previous research has shown that surgery in a Dutch Adrenal Network (DAN) center increases the chance of survival. We aim to explore the determinants and survival of patients with ACC recently treated in the Netherlands both within and outside DAN centers.MethodsWe analyzed retrospectively collected data from 172 adult patie...

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ea0073aep2 | Adrenal and Cardiovascular Endocrinology | ECE2021

Characteristics of pheochromocytomas/paragangliomas in Flemish population

Sofia Maria Lider Burciulescu , Guy T’Sjoen , Badiu Corin , Bruno Lapauw

IntroductionPheochromocytomas (PHEO) and paragangliomas (PGL) are rare neuroendocrine tumors of the autonomic nervous system, originating from neural crest. Despite the same embryological origin, there are some differences between them.AimWe searched for differences in method of discovery, clinical and biochemical phenotype, of sporadic vs hereditary PHEO/PGL in a cohort of Flemish patients.<p class="abst...

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ea0073aep3 | Adrenal and Cardiovascular Endocrinology | ECE2021

Effective metyrapon treatment of a case of neonatal cushing syndrome of unknown origin

Gacs Zsofia , Borbála Tobisch , Ágnes Sallai , Viktória Kemény , Butz Henriett , Varga Edit

Neonatal Cushing syndrome (CS) is a rather rare disease. The majority of these few cases are of ACTH dependent origin or caused by a unilateral adrenal tumour (carcinoma or adenoma), however ACTH independent bilateral hyperplasias stand for only a few percent of all cases. The management of neonatal CS depends on the underlying cause if found in time - of the disease. In the past the survival rate of children with CS was low, new and renewed medical attempts have improv...

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ea0073aep4 | Adrenal and Cardiovascular Endocrinology | ECE2021

Biomarkers of cardiovascular disease and inflammation in autoimmune addison’s disease with residual adrenocortical function

Åse Bjorvatn Sævik , Anna-Karin Åkerman , Methlie Paal , Quinkler Marcus , Anders Jørgensen , Charlotte Höybye , Debowska Aleksandra , Bjørn Gunnar Nedrebø , Dahle Anne Lise , Carlsen Siri , Tomkowicz Aneta , Synnøve Holte , Sollid Stina Therese , Nermoen Ingrid , Kaja Grønning , Dahlqvist Per , Grimnes Guri , Skov Jakob , Finnes Trine , Valland Susanna , Wahlberg Jeanette , Simunkova Katerina , Olle Kämpe , Husebye Eystein Sverre , Bensing Sophie , Marianne Øksnes

BackgroundResidual adrenocortical function (RAF) is present in one third of patients with autoimmune Addisons disease (AAD), yet its clinical significance remains unknown.ObjectiveTo investigate if biomarker profiles of cardiovascular disease and inflammation are different in patients with AAD and RAF compared to patients without RAF and healthy controls.Material and methods<p...

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ea0073aep5 | Adrenal and Cardiovascular Endocrinology | ECE2021

The role of Chchd2 protein in adrenal tumorigenesis

Moustogiannis Athanasios , Karapanagioti Angeliki , Nasiri-Ansari Narjes , Zografos Giorgos , Aggeli Chrysanthi , Kyriakopoulos Georgios , Choreftaki Theodosia , Philippou Anastassios , Kaltsas Gregory , Kassi Evanthia , Angelousi Anna

BackgroundRecent data have shown the anti-apoptotic effect of Chchd2 mitochondrial protein through the Bcl-2/Bax pathway in various cancers. Bax is regulated primarily by proteins-members of Bcl-2 family and mainly the Bcl-2 protein, which has been found to prevent Bax from accumulating in mitochondria. In response to apoptotic stimuli, Chchd2 decreases and loses its mitochondria localization accompanying by decreased Bcl-2/Bax interaction and increased ...

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ea0073aep6 | Adrenal and Cardiovascular Endocrinology | ECE2021

Salivary profiles of 11-oxygenated androgens follow a diurnal rhythm in patients with congenital adrenal hyperplasia

Nowotny Hanna F. , Auer Matthias K. , Lottspeich Christian , Schmidt Heinrich , Dubinski Ilja , Bidlingmaier Martin , Adaway Jo , Hawley James , Keevil Brian , Reisch Nicole

BackgroundRoutine biochemical assessment in patients with congenital adrenal hyperplasia (CAH) includes measurement of serum 17hydroxyprogesterone (17OHP), androstenedione (A4) and testosterone (T) and their metabolites in urine. Several studies have also described 11oxygenated 19carbon (110 × C19) steroids as a clinically relevant androgenetic source and highlighted their potential as markers for evaluation of adrenal androgen exc...

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ea0073aep7 | Adrenal and Cardiovascular Endocrinology | ECE2021

Unnecessary cosyntropin stimulation tests for nonclassic congenital adrenal hyperplasia (NCAH) – shall the cut-off value of 17-hydroxyprogesterone be revised?

Bartosz Domagala , Trofimiuk-Muldner Malgorzata , Krawczyk Anna , Joanna Topór-Kolkowska , Skalniak Anna , Przybylik-Mazurek Elwira , Pach Dorota , Hubalewska-Dydejczyk Alicja

Cosyntropin stimulation test is the gold diagnostic standard used to test for NCAH. Genetic testing is not currently considered to be the primary diagnostic tool for NCAH. Still, it may be helpful in establishing a diagnosis if other results are unequivocal or for genetic counselling purposes. The study aimed at verifying the currently accepted threshold of 17-hydroxyprogesterone (17OHP) level (3 2.0 ng/ml) at which a cosyntropin stimulation test should be performed...

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ea0073aep8 | Adrenal and Cardiovascular Endocrinology | ECE2021

Zona glomerulosa derived Klotho does not regulate aldosterone synthesis in young mice

Tang Cong , Xie Ye , Scapin Alessia , Loffing Dominique , Breault David , Loffing Johannes , Beuschlein Felix

Klotho (Kl), initially identified as an antiaging gene, plays a critical role in the regulation of renal and adrenal dependent fluid homeostasis. A previous study reported that haplodeficiency of Kl in mice resulted in increased aldosterone synthase (CYP11B2) expression, elevated plasma aldosterone and high blood pressure. This phenotype was presumed to result from diminished Kl expression in zona glomerulosa (zG) of the adrenal. To examine whether Kl expressed in zG is indeed...

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ea0073aep9 | Adrenal and Cardiovascular Endocrinology | ECE2021

Effects of adrenalectomy on arterial hypertension, glucose and lipid metabolism in patients with mild autonomous cortisol secretion: preliminary results of a Randomized Clinical Trial

Frigerio Sofia , Morelli Valentina , Aresta Carmen , Elena Passeri4 , Pugliese Flavia , Corbetta Sabrina , Scillitani Alfredo , Arosio Maura , Chiodini Iacopo

IntroductionThe management of patients with adrenal incidentaloma (AI) and mild autonomous cortisol secretion (MACS) is debated. This randomized study aimed to evaluate the effects of adrenalectomy on arterial hypertension (AH), glucose and lipid metabolism.MethodsWe consecutively evaluated 626 AI patients (referred to 3 Italian Centers between 06/2016 and 02/2020). According to the inclusion criteria, we enr...

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ea0073aep10 | Adrenal and Cardiovascular Endocrinology | ECE2021

A very rare case of extranodal lymphoma with adrenal and heart involvement

Papanastasiou Labrini , Skarakis Spyridon Nikitas , Michalis Eurydiki , Vardaka Maria , Lampropoulou Pinelopi , Lymperopoylos Konstantinos , Choreftaki Theodosia , Dimitriadi Anastasia , Perpinia Anastasia , Papadimitriou Eirini , Markou Athina , Marinakis Theodoros , Ioannis-Anastasios Vatalas , Kounadi Theodora

BackgroundExtranodal non-Hodgkin lymphoma (NHL) is a rare condition that accounts for less than one-third of patients with NHL at diagnosis. The heart or the endocrine organs (adrenals) involvement is extremely rare.ObjectiveWe report an unusual case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma) presenting with heart and bilateral adrenal involvement.Design...

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ea0073aep11 | Adrenal and Cardiovascular Endocrinology | ECE2021

The role of estimated glucose disposal rate as a predictor of insulin resistance, NAFLD and major adverse cardiovascular events in type 1 diabetes mellitus

Mertens Jonathan , Block Christophe De , Dirinck Eveline , Francque Sven

Background and AimsPeople with type 1 diabetes (T1D) have an increased risk of cardiovascular disease (CVD) despite insulin therapy to treat hyperglycaemia. Insulin resistance may be a contributing factor to CVD. Insulin resistance is strongly associated with NAFLD, which is increasingly linked to CVD. The estimated glucose disposal rate (eGDR) correlates well with the euglycemic clamp, which is the gold standard to assess insulin resistance in T1D, but ...

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ea0073aep12 | Adrenal and Cardiovascular Endocrinology | ECE2021

Niemann-Pick disease and endocrine disorders: A case report

Benothman Wafa , Kacem Maha , Saad Ghada , Khaldi Safa , Benabdelkrim Asma , Maaroufi Amel , Chaeib Molka , Hasni Yosra , Ach Koussay

IntroductionAcid sphingomyelinase-deficient NiemannPick disease (NPD) is a lysosomal lipid storage disorder. We report a new case of Hashimoto thyroiditis associated to primary adrenal insufficiency (PAI) likely of infiltrative process occurring in NPD type B patient.ObservationA 24-year-old Tunisian female patient was followed up in our endocrinology department for Hashimoto thyroiditis. Two years late...

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ea0073aep13 | Adrenal and Cardiovascular Endocrinology | ECE2021

Epidemiology, clinical course, and genetic analysis of pheochromocytomas/paragangliomas: A single centre tertiary care experience over 16 years from crete-greece

Chrysoulaki Maria , Fostira Florentia , Daraki Vasiliki , Betsi Grigoria , Sfakiotaki Maria , Mytilinaiou Maria , Bouki Katerina , Stathias Konstantinos , Spanakis Konstantinos , Panagiotis-Nikolaos Tsakalomatis , Eleni-Konstantina Syntzanaki , Kontolaimaki Kalliopi , Vamvoukaki Rodanthi , Nastos Konstantinos , Xekouki Paraskevi

BackgroundPheochromocytomas (PHOEs) and paragangliomas (PGLs) are rare neuroendocrine tumors originating from chromaffin cells. PHEO/PGL incidence ranges between 28/million, with 1049% of these tumors being detected incidentally during imaging performed for other reasons. Up to 40% of PHEOs/PGLs patients have disease-specific germline pathogenic variants. This study aimed to investigate the epidemiology, clinical course, and genetic backgroun...

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ea0073aep14 | Adrenal and Cardiovascular Endocrinology | ECE2021

Differential phenotype of bilateral macronodular adrenal hyperplasia and other bilateral adrenal lesions with associated subclinical hypercortisolism. Study of 98 patients

Rojano Nuria Bengoa , Maria Fernandez Argüeso , Pascual-Corrales Eider , José I. Botella-Carreter , Araujo-Castro Marta

PurposeTo evaluate the prevalence of bilateral macronodular adrenal hyperplasia (BMAH) in patients with adrenal incidentalomas (AIs) and analyse the differential phenotype of patients with BMAH compared to other bilateral adrenal lesions which do not meet BMAH definition (non-BMAH), with associated possible or confirmed autonomous cortisol secretion (ACS).MethodsRetrospective study of patients with AIs diagno...

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ea0073aep15 | Adrenal and Cardiovascular Endocrinology | ECE2021

Effect of retinoic acid on adrenal primary cultures from patients with Cushing’s disease

Giraldi Francesca Pecori , Sesta Antonella , Tapella Laura , Cassarino Maria Francesca , Castelli Luigi

Retinoic acid, a major modulator of adrenal development and differentiation, has also been shown to inhibit ACTH secretion by tumoral corticotropes. Recent clinical trials in patients with Cushings disease revealed that retinoic acid exerts beneficial effects in these patients (1, 2). Of note, the decrease in cortisol secretion during retinoic acid administration was more pronounced than the change in ACTH levels (1) suggesting a direct action at adrenal level. Aim of th...

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ea0073aep16 | Adrenal and Cardiovascular Endocrinology | ECE2021

Typical obese patient with an adrenal incidentaloma is a menopausal female with an unilateral nonfunctioning tumor – a single centre experience

Marina Ljiljana , Sojat Antoan Stefan , Vujovic Svetlana , Tancic-Gajic Milina , Arizanovic Zorana , Lazovic Jelena Milin , Kendereski Aleksandra , Dunja-Simona Petkovic , Saravinovska Kristina , Stankovic David , Rosic Natasa , Ivovic Miomira

IntroductionThe connection between obesity and tumorigenesis has been well established.AimThe aim of this study was to elucidate if there are any demographic and functional differences in adrenal incidentalomas (AI) with respect to different body mass index (BMI) categories.Patients and methodsThis was an observational, cross sectional study. The AI cohort consist...

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ea0073aep17 | Adrenal and Cardiovascular Endocrinology | ECE2021

Cost-effectiveness of empagliflozin plus metformin vs metformin alone as first-line therapy in patients with type 2 diabetes mellitus: An australian perspective

Abushanab Dina , Liew Danny , marquina Clara , Al-Badriyeh Daoud , Ademi Zanfina

BackgroundSodium-glucose cotransporter 2 (SGLT2) inhibitors are potentially an attractive option for initial combination therapy with metformin for type 2 diabetes mellitus (T2DM), which may help patients to achieve adequate glycaemic control and reduce cardiovascular disease (CVD). Empagliflozin has been shown to be superior compared to other SGLT2 inhibitors in reducing all-cause and cardiovascular mortality in patients with T2DM.<p class="abstext"...

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ea0073aep18 | Adrenal and Cardiovascular Endocrinology | ECE2021

Klinefelter syndrome: Beyond hypogonadism

Inês Vieira , Bastos Margarida , Luísa Ruas , Dírcea Rodrigues , Gomes Leonor , Paiva Isabel

IntroductionIn Klinefelter syndrome, hypergonadotropic hypogonadism is the most prominent endocrine-metabolic disorder. However, a higher prevalence of cardiovascular risk factors has also been reported.ObjectivesIn a sample of individuals with Klinefelter Syndrome (KS): to document the diagnostic context; to assess the prevalence of cardiovascular risk factors (CVRF) and compare it with a contr...

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ea0073aep19 | Adrenal and Cardiovascular Endocrinology | ECE2021

Aryl hydrocarbon receptor Interacting Protein (AIP) status in a functional adrenal adenoma occurring in a patient with a germline AIP mutation

Feola Tiziana , Capelli Roberta , Gianno Francesca , Compagnoni Chiara , Letizia Claudio , Toma Giorgio De , Ciardi Antonio , Vincentis Giuseppe De , Giangaspero Felice , Tessitore Alessandra , Marie-Lise Jaffrain-Rea

IntroductionAryl hydrocarbon receptor Interacting Protein (AIP), a pituitary tumour suppressing gene located in 11q13, is the most common predisposing gene for early-onset and familial acromegaly. Fifteen years after its identification, there is little evidence of AIP involvement in non-pituitary tumors. We had the opportunity to study AIP status in a cortisol-producing adenoma operated in an AIP mutation carrier.Case-report<p ...

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ea0073aep20 | Adrenal and Cardiovascular Endocrinology | ECE2021

The association between adrenal adenomas’ size, autonomous cortisol secretion and metabolic derangements

Bleier Jonathan , Pickovsky Jana , Fishman Boris , Dotan Zohar , Tirosh Amir , Shlomai Gadi

ObjectiveAutonomous cortisol secretion (ACS) is the most common hypersecretion syndrome present in patients diagnosed with adrenal incidentalomas (AI). ACS is associated with various metabolic derangements. Thus far, very few and mostly inconclusive data exists regarding the association between AIs radiological characteristics and hormonal functionality. In this study we assessed the associations between radiological characteristics of incidentally...

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ea0073aep21 | Adrenal and Cardiovascular Endocrinology | ECE2021

Metabolic and Inflammation markers in patients with mild autonomous cortisol secretion: preliminary results of a Randomized Clinical Trial

Morelli Valentina , Frigerio Sofia , Perego Silvia , Lombardi Giovanni , Aresta Carmen , Pugliese Flavia , Scillitani Alfredo , Arosio Maura , Corbetta Sabrina , Chiodini Iacopo

IntroductionIrisin is a molecule secreted from skeletal muscle and contributes to maintenance of metabolic homeostasis leading to increased energy expenditure and reducing the risk of obesity and diabetes. Literature data suggest that patients with Cushing disease have lower irisin values than controls and remission of hypercortisolism increases these values. Moreover, other plasma inflammation markers implicated in the pathogenesis of atherosclerosis, i...

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ea0073aep22 | Adrenal and Cardiovascular Endocrinology | ECE2021

Impact of adrenal insufficiency on female sexual function: A preliminary study

Zamponi Virginia , Mazzilli Rossella , Maggio Roberta , Lardo Pina , Olana Soraya , Pugliese Giuseppe , Faggiano Antongiulio , Stigliano Antonio

IntroductionAdrenal insufficiency is a clinical condition that leads to depletion of glucocorticoids, mineralocorticoids and androgens. While in men adrenal androgen deficiency is not clinically significant for testicular testosterone synthesis, in women so far androgen treatment is suggested for the reduction of libido and depression. However, no data is currently available on female sexual function.Primary endpoints<p class="...

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ea0073aep23 | Adrenal and Cardiovascular Endocrinology | ECE2021

Adrenal cysts – a rare entity

Nádia Mourinho Bala , Raposo Nuno , Sílvia Guerra , José Maria Aragüés , Valadas Cristina

IntroductionAdrenal cyst lesions are uncommon and only a few large series have been reported. The pathogenesis is unclear. Currently, adrenal cystic lesions are categorized into endothelial cysts, pseudocysts, epithelial cysts and parasitic cysts. In most cases they are found incidentally in asymptomatic patients or in patients with non-specific gastrointestinal symptoms. We describe three cases of adrenal cysts.Case report<p c...

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ea0073aep24 | Adrenal and Cardiovascular Endocrinology | ECE2021

One train may hide another: Scleromyositis in a patient with peripheral adrenal insufficiency

Abir Derbel , Mouna Snoussi , Mouna Guermazi , Feten Frikha , Chifa Dammak , Salah Raida Ben , Sameh Marzouk , Zouhir Bahloul

IntroductionPatients with primary adrenal insufficiency (PAI) may have musculoskeletal symptoms. However, the association of such endocrinopathy with scleromyositis is extremely rare and has not been reported formerly to our acknowledge. Herein we report this association.Case reportA 32-years old female with one year history of profound global weakness was referred to internal department in April 2006, for su...

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ea0073aep25 | Adrenal and Cardiovascular Endocrinology | ECE2021

Oral and dental manifestation of Allgrove syndrome: A case report

Dhoha Ben Salah , Charfi Hana , Mouna Elleuch , Wajdi Safi , Fatma Mnif , Mouna Mnif , Nadia Charfi , Nabila Rekik , Faten Hadj Kacem , Mohamed Abid

IntroductionTriple-A syndrome, also known as Allgrove syndrome, is a rare autosomal recessive disorder. It is a multisystemic disease with an estimated prevalence of 1 per 1 000 000 individuals The 3 features of this syndrome are achalasia, adrenal insufficiency, and alacrima. Recently, dental impairment has been the subject of several case reports and reviews. However, this abnormality remains under-diagnosed.Purpose<p class="...

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ea0073aep26 | Adrenal and Cardiovascular Endocrinology | ECE2021

Adrenal steroid profiling in the diagnostics of partial enzyme defects in the adrenals. Establishment of normal cut-off levels using LC-MS/MS

Grethe Åstrøm Ueland , Dahl Sandra R. , Methlie Paal , Husebye Eystein , Thorsby Per Medboe

BackgroundNon-classical congenial adrenal hyperplasia (NCCAH) is an important differential diagnosis in women with acne, hirsutism, menstrual abnormalities and infertility. To diagnose NCCAH can be challenging, and currently used cutoff levels are based on unstandardized immunological assays, no longer in use.ObjectiveDefine LC-MS/MS based cut-off levels for steroid hormones, to improve diagnosis of NCCAH and...

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ea0073aep27 | Adrenal and Cardiovascular Endocrinology | ECE2021

Clinical and pathological characteristics of pheochromocytoma and paraganglioma: Single center experience

Akcay Seckin , Korkmaz Fatma Nur , Culci Pelin Bagci , Özlem Üstay , Yavuz Dilek Gogas

AimPheochromocytoma and paraganglioma are rare neuroendocrine tumors, that can be diagnosed incidentally or with symptoms that may be confused with other diseases. In our study, we aimed to demonstrate our clinical biochemical and pathological experiences with pheochromocytoma and paraganglioma cases.MethodThe clinical, biochemical, radiological, and pathological data of a total of 79 patients diagnosed with ...

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ea0073aep28 | Adrenal and Cardiovascular Endocrinology | ECE2021

Effects of sorafenib, a tyrosin kinase inhibitor, on adrenocortical cancer cell line

Cerquetti Lidia , Bucci Barbara , Raffa Salvatore , Lardo Pina , Maggio Roberta , Simonini Chiara , Petrangeli Elisa , Toscano Vincenzo , Pugliese Giuseppe , Stigliano Antonio

The lack of an effective medical treatment for adrenocortical carcinoma (ACC) has prompted the, search for better treatment protocols for ACC neoplasms. Sorafenib, a tyrosine kinase inhibitor has exhibited effectiveness in the treatment of different human tumors. Therefore, the aim of this study was to understand the mechanism through which sorafenib acts on ACC, especially since treatment with sorafenib alone is sometimes unable to induce a long-lasting antiproliferative effe...

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ea0073aep29 | Adrenal and Cardiovascular Endocrinology | ECE2021

Incidental detection of adrenal hyperplasia and mortality in patients with suspected SARS-CoV-2 Infection

Reimondo Giuseppe , Solitro Federica , Puglisi Soraya , Casale Davide , Tiranti Giorgia Maria , Perini Anna , Cultrera Alessandra , Caramello Valeria , Boccuzzi Adriana , Pia Anna , Terzolo Massimo , Veltri Andrea

Many patients affected by SARS-CoV-2 disease (COVID) have associated comorbidities (arterial hypertension, obesity, diabetes mellitus, thrombophilia) that are also tied to autonomous cortisol secretion. However, the prevalence of diseases of the adrenal glands in COVID patients is presently unknown. Since the visualization of the adrenal glands is almost always available in chest CT performed in patients with suspected or confirmed SARS-CoV-2 infection, the evaluation of adren...

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ea0073aep30 | Adrenal and Cardiovascular Endocrinology | ECE2021

Repeated hormonal and radiological evaluation of hypertensive patients is necessary for correct primary aldosteronism diagnosis and treatment

Agnieszka Łebek-Szatan´ska , Leszczynska Dorota , Nowak Karolina , Tuszynska Agata , Zgliczynski Wojciech , Papierska Lucyna

BackgroundPrimary aldosteronism (PA) constitutes the most common form of hormonal hypertension. However, it is very often misdiagnosed and incorrectly managed. Detection rates are inadequately low and the interpretation of hormonal results is impossible in some patients. Subtype evaluation with its several limitations represents another problematic issue. We describe the cases of two young primary aldosteronism patients with complicated history and a few...

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ea0073aep31 | Adrenal and Cardiovascular Endocrinology | ECE2021

Unilateral extramedullary adrenal plasmocytoma: A case report

Bahar Nabila , Colard Martin , Vouche Michael , Lucidi Valerio , Bernard Corvilain , Driessens Natacha

We present the case of an octogenarian with a major history of lambda light chain myeloma which was treated by a first-line lenalidomide and dexamethasone from June 2018 to September 2019. Patient had also hypertension and valvular heart disease (mechanical valve and anticoagulation by acenocoumarol). In September 2019, a right adrenal mass was incidentally discovered by a renal ultrasonography made for acute kidney injury. The abdominal CT-scan confirmed the presence of a lar...

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ea0073aep32 | Adrenal and Cardiovascular Endocrinology | ECE2021

A rare association of pheochromocytoma, contralateral nonfunctioning adrenal adenoma, and renal angiomyolipoma

Naouar Raoua , Amor Bilel Ben , Sayadi Hanene , Salem Houda Ben , Bayar Ines , Héla Marmouch , Inès Khochteli

IntroductionBilateral adrenal incidentalomas represent about 15% of adrenal incidentalomas. Their investigation and management are less discussed and more challenging than unilateral incidentalome. A special attention is required because they are more likely to be pathologic. When associated with a synchronous extra-adrenal tumor, the first diagnosis is adrenal metastasis, but this is not always true. Here we present a rare association of pheochromocytom...

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ea0073aep33 | Adrenal and Cardiovascular Endocrinology | ECE2021

Initial therapy with empagliflozin in addition to metformin vs standard therapy alone for patients with type 2 diabetes mellitus and cardiovascular disease in qatar. A cost-effectiveness analysis

Abushanab Dina , Al-Badriyeh Daoud , Liew Danny , Ademi Zanfina

BackgroundSodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to reduce deaths and cardiovascular events in patients with type 2 diabetes mellitus (T2DM), but are currently not used as first-line therapy.ObjectiveTo evaluate the cost-effectiveness of introducing empagliflozin into the current standard care (metformin monotherapy) for patients with newly diagnosed T2DM and existing cardiovascular...

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ea0073aep34 | Adrenal and Cardiovascular Endocrinology | ECE2021

Metabolic, renal and cardiovascular status in patients with primary hyperaldosteronism

Cherchir Faten , Oueslati Ibtissem , Yazidi Meriem , Chaker Fatma , Chihaoui Melika

IntroductionPrimary hyperaldosteronism (PHA) is an increasingly prevalent cause of endocrine hypertension. It is characterized by unregulated aldosterone secretion with an excessive activation of mineralocorticoid receptors, inducing volume expansion, hypokalemia, endothelial dysfunction and fibrotic processes in the renal and cardiovascular systems. The aim of this study was to assess the metabolic, renal, and cardiovascular status in patients with prim...

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ea0073aep35 | Adrenal and Cardiovascular Endocrinology | ECE2021

24-Hour blood pressure profile in patients with adrenal insufficiency

Chifu Irina , Krause Kristina , Zetsche Adrian , Scheuermann Carolin , Burger-Stritt Stephanie , Hahner Stefanie

Introduction Retrospective analyses suggest that patients with adrenal insufficiency (AI) have an increased risk for cardiovascular diseases which was mainly attributed to non-physiological cortisol profiles and/or supraphysiological replacement doses.Material and methodsWe analyzed the 24-hour blood pressure (BP) profiles in patients with primary (PAI) and secondary (SAI) AI. BP threshold criteria for hypert...

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ea0073aep36 | Adrenal and Cardiovascular Endocrinology | ECE2021

The acute effects of milk intake on calcium homeostasis and cardiovascular outcome: A randomized, crossover trial in postmenopausal women

Espersen Rasmus , Rejnmark Lars

IntroductionThe importance of calcium intake from dairy has been investigated in several studies with discrepant results. Meta-analyses have shown beneficial effects of dairy intake on cardiovascular health with an inverse association between intake and cardiovascular disease. However, a recent trial has suggested an increase in blood pressure in the hours following intake of 1000 mg of calcium citrate compared with placebo. So far, it has not been inves...

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ea0073aep37 | Adrenal and Cardiovascular Endocrinology | ECE2021

Natural history of nonfunctioning adrenal incidentalomas: A 10-year longitudinal observational study

Jensterle Mojca , Tomaž Kocjan , Rakusa Matej , Janez Andrej , Popovic Peter , Podbregar Ana

ObjectiveThere are few data on long-term follow-up of patients with nonfunctioning adrenal incidentalomas (NFAIs). We aimed to determine the natural history of NFAI at 10 year follow-up. We also evaluated the associations between baseline body mass index (BMI) and changes of NFAIs and patients characteristics at follow-up period.DesignLongitudinal observational study.Patient...

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ea0073aep38 | Adrenal and Cardiovascular Endocrinology | ECE2021

Low-renin hypertension with normal or high aldosterone levels is a cause of severe hypertension, and can be diagnosed by applying endocrine society hyperaldosteronism guidelines

Xavier Pérez Candel , Ramos Elvira , Barrio Elvira , Jorge Gabriel Ruiz Sánchez , Martín Cuesta Hernández , Pazos Mario , Carreiro Sara Mera , Madrid Blanca Bernaldo , Calle Alfonso , Runkle Isabel

Low-renin hypertension (LRH) with normal or elevated aldosterone levels is considered part of the spectrum of aldosterone-associated hypertension, and can cause poorly-controlled hypertension. We studied patients diagnosed with LRH, comparing their clinical and biochemical characteristics with patients diagnosed with primary hyperaldosteronism (PHA). Methods Retrospective. Diagnosis in a general Endocrinology out-patient clinic ove...

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ea0073aep39 | Adrenal and Cardiovascular Endocrinology | ECE2021

Increasing incidence of primary aldosteronism – yet an underdiagnosed disorder

Gkaniatsa Eleftheria , Ekerstad Eva , Gavric Emanuela , Trimpou Penelope , Olsson Daniel S. , Johannsson Gudmundur , Ragnarsson Oskar

ContextPrimary aldosteronism (PA) is the most common cause of secondary hypertension. Yet, the incidence of PA in the population has not been studied.ObjectiveTo estimate the incidence of PA in western Sweden.Design and methodsPatients who had received a diagnostic code for PA between 1987 and 2016 were identified in the Swedish National Patient Registry. Assessme...

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ea0073aep40 | Adrenal and Cardiovascular Endocrinology | ECE2021

A Clinically silent, non-secretory phaeochromocytoma

Lewis Megan , Ahmed M Gharib Ahmed , Lambert Paul

Adrenal incidentalomata are a common finding on cross-sectional imaging of the abdomen. Further assessment is required to differentiate benign adrenal masses from adrenocortical carcinomas and hormone-secreting tumours. Phaeochromocytomas are rare catecholamine-secreting tumours arising from chromaffin cells of the adrenal medulla. They classically present with symptoms and signs of catecholamine excess including headache, sweating, hypertension and tachycardia. However, with ...

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ea0073aep41 | Adrenal and Cardiovascular Endocrinology | ECE2021

A case of adrenergic myocarditis in pheochromocytoma mimicking COVID-19 pneumonia

Adel Meriem , Rojbi Imen , Majdoub Marwa , Mchirgui Nadia , Lakhoua Youssef , Nacef Ibtissem Ben , Khiari Karima

IntroductionPheochromocytomas are rare catecholamine-producing neuroendocrine tumors derived from the sympathetic or parasympathetic nervous system. The clinical presentation of pheocromocytoma has varying forms, which makes diagnosing it challenging. Here, we report a case of Adrenergic cardiomyopathy mimicking COVID-19.Case reportA 40-year-old woman with a history of pulmonary edema during cesarean delivery...

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ea0073aep42 | Adrenal and Cardiovascular Endocrinology | ECE2021

A case of adrenal tuberculosis mimicking non-functioning adrenal incidentaloma

Hirani Dhruti , Ladha Tasneem , Khan Shaila , Hilal Zaib , Palazzo Fausto , Vakilgilani Tannaz

A 77 year old gentleman was referred to the endocrinology team following the incidental finding of an adrenal nodule on computer tomography (CT) colonography. Following this, dedicated CT of the adrenal showed a 4cm nodule with an attenuation of 30 Hounsfield Units. Biochemical investigation found no evidence of adrenal insufficiency or functional hormone production. Subsequent imaging by magnetic resonance imaging (MRI) and further CT showed stable appearances in size of the ...

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ea0073aep43 | Adrenal and Cardiovascular Endocrinology | ECE2021

Evaluation of metabolic profile and thyroid disease in non functional adrenal insidentaloma patients

Kural Ragip Fatih , Oruk Gonca , Kural Elif Ersen

AimNonfunctional adrenal incidentalomas (NFAIs) are often associated with a high prevalence of insulin resistance (IR). The relationship between IR and thyroid diseases, as well as, thyroid cancer (TC) in patients with NFAI is not yet understood. The aim of this study is to determine the frequency of thyroid disease and TC in NFAI patients and to investigate any possible association of thyroid disease with IR and metabolic disturbances in NFAI pati...

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ea0073aep44 | Adrenal and Cardiovascular Endocrinology | ECE2021

Bilateral adrenal masses caused by extramedullary hematopoiesis detected by 18F-FLT PET/CT

Korkmaz Fatma Nur , Özgür Demir , Ozkan Elgin , Araz Mine , Özlem Küçük , Ceyhan Koray , Demet Çorapçıog˘lu

IntroductionExtramedullary hematopoiesis (EMH) refers to hematopoiesis occurring outside the bone marrow. Pathologic EMH can be caused by thalassemias or disorders in the hematopoietic system. Sites of EMH can be widespread however, most common localizations are in the spleen, liver, and lymph nodeCase reportA 22-year-old male patient was referred to the endocrinology department for bilateral adrenal masses f...

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ea0073aep45 | Adrenal and Cardiovascular Endocrinology | ECE2021

The role of E47 in patients with endogenous cortisol excess

Zhang Wei , Nowotny Hanna F. , Zopp Stephanie , Bidlingmaier Martin , Reincke Martin , Uhlenhaut Henriette , Reisch Nicole

ContextE47 is a transcription factor mostly known for its role in B and T cell lineage commitment. Recently E47 was identified as a modulator of glucocorticoid receptor target genes, its loss protecting mice from metabolic adverse effects of glucocorticoids. Patients with Cushings syndrome (CS) suffer from an endogenous glucocorticoid excess due to tumour formation associated with a variety of metabolic comorbidities seriously affecting patients&#1...

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ea0073aep46 | Adrenal and Cardiovascular Endocrinology | ECE2021

High-normal serum uric acid levels in Type 2 diabetes patients with atherosclerotic cardiovascular diseases

Khalaf Rahma , Ali Zohra Hadj , Htira Yosra , Mami Faika Ben

Background and aimHyperuricemia is linked to a variety of diseases such as atherosclerotic cardiovascular disease (ASCVD). There are controversial data concerning the significance of high-normal values of serum uric acid (SUA) in patients with T2DM and cardiovascular disease. The aim of the study is to assess SUA levels in Type 2 diabetes mellitus (T2DM) patients with ASCVD.Patients and methodsThis retrospect...

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ea0073aep47 | Adrenal and Cardiovascular Endocrinology | ECE2021

Associations between the atherogenic index of plasma, cardiovascular and metabolic risk in patients with primary hyperaldosteronism

Cherchir Faten , Oueslati Ibtissem , Yazidi Meriem , Chaker Fatma , Chihaoui Melika

IntroductionPrimary hyperaldosteronism (PHA) represents the most common cause of secondary hypertension. It is associated with a high risk of cardiovascular diseases (CVD), suggesting that aldosterone is implicated in the development of early atherosclerosis. Clinical studies have shown that atherogenic index of plasma (AIP) predicts cardiovascular risk. The aim of this study was to assess the associations between atherogenic index of plasma and cardiova...

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ea0073aep48 | Adrenal and Cardiovascular Endocrinology | ECE2021

Lipid paradox in acute myocardial infarction

Correia Sara , Ramalho Diogo , Almeida Lucia , Alves Helena , Melo Gustavo , Maria João Oliveira

IntroductionSome studies have shown low-density lipoprotein cholesterol (LDL) and triglyceride (TG) levels were significantly lower in high-Killip (III + IV) patients compared with low-Killip (I + II) patients and in those who died after acute myocardial infarction (AMI) compared with those who survived beyond 30 days, which they called lipid paradox. Elevated levels of LDL and triglycerides are important risk factors for cardiovascular disease, ...

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ea0073aep49 | Adrenal and Cardiovascular Endocrinology | ECE2021

Hair cortisol levels in patients with adrenal incidentalomas compared to healthy controls

Athanasouli Fani , Mytareli Chrysoula , Andreadaki Evangelia , Petychaki Foteini , Savelli Akrivi , Asonitis Nikos , Anna Angelousi

BackgroundAdrenal incidentalomas (AI) are present in 310% of the general population. Up to 20% of them may have autonomous cortisol secretion (ACS). However, subclinical hypercortisolism isnt clearly defined. The 1mg dexamethasone suppression test (ODST) is the most widely accepted for the screening of these patients. Recent data suggest that hair cortisol should be considered as a routine test for the screening of Cushing syndrome.<p cla...

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ea0073aep50 | Adrenal and Cardiovascular Endocrinology | ECE2021

Incidentally diagnosed bilateral pheochromocytoma accompanied by urothelial carcinoma of the bladder

Tufekci Damla , Gunay Yasemin Emur , Demir Ahmet Suat , Bilginer Muhammet Cuneyt , Coskun Hulya , Nuhoglu Irfan , Ucuncu Ozge , Kocak Mustafa

IntroductionAdrenal abnormalities can be detected incidentally during the imaging performed for malignancies. These abnormalities may include adrenal pathological conditions independent of primary malignancies. Pheochromocytomas detected as part of some familial syndromes are often bilateral.In this report, we present a case of isolated sporadic bilateral pheochromocytoma that was incidentally detected during malignancy workup and staging, which is a rar...

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ea0073aep51 | Adrenal and Cardiovascular Endocrinology | ECE2021

Occult aldosteronoma mimicking degenerative spine disease

Sausa Sintija , Priede Zanda , Gardovskis Janis , Niciporuka Rita , Jukone Unda , Ivanova Santa , Pirags Valdis , Fokina Natalija

68 years old Caucasian women presented to the emergency department (ED) with complains of stiffness, intolerable pain in lumbosacral region and inability to walk for last two days. The common pain-relieving medications did not subdue her pain. The patient had experienced similar episodes for two years, provoked by remaining in fixed position or after having carbohydrate rich meal. Pain usually persisted for a few minutes and symptoms disappeared after light exercise. Her compl...

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ea0073aep52 | Adrenal and Cardiovascular Endocrinology | ECE2021

Oligosymptomatic positive SDHB gene mutation paraganglioma

Andra-Maria Olteanu , Capota Ruxandra , Dumitru Nicoleta , Diaconu Daniel , Ghemigian Adina

IntroductionEndocrinopathies represent about 13% of secondary hypertension.The non-head-neck paragangliomas are rare neuroendocrine tumors that arise from the ganglia of the sympathetic nervous system. About 75% are intra-adbdominal, thus they are often mistaken for adrenal pheocromocitoma.They usually secret normetanephrine and chromogranin A, which are responsible of 0.20.6% of secondary hypertension.Objective<p c...

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ea0073aep53 | Adrenal and Cardiovascular Endocrinology | ECE2021

Pheochromocytomas: Diagnosis, treatment and clinical outcomes

Derkaoui Nada , Imane Rami , Yakhlef Salma Ben , Rouf Siham , Latrech Hanane

IntroductionPheochromocytomas originate in the adrenal medulla. Although rare, they can be lethal through their cardiovascular complications. They may be sporadic or come in the context of hereditary syndroms. The aim of our work is to describe the clinical, biological and radiological features of these tumors and assess the clinical outcomes after surgical treatment.Materials and methodsOur study is retrospe...

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ea0073aep54 | Adrenal and Cardiovascular Endocrinology | ECE2021

Adrenal function recovery after successful surgery for Cushing

Marin Alexandra , Mihai Daniel , Caragheorgheopol Andra , Badiu Corin

BackgroundCushing syndrome (CS) is caused by prolonged exposure to elevated cortisol levels and its classified as either ACTH-dependent or ACTH independent CS. The most common form of endogenous ACTH CS is Cushing disease (CD); ACTH-independent CS is caused by various adrenal abnormalities. First-line therapy in CS is the resection of the underlying tumor in all cases. After surgical cure of CS, most patients develop transient secondary adrenal ins...

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ea0073aep55 | Adrenal and Cardiovascular Endocrinology | ECE2021

Pulmonary metastasis of a pure oncocytic adrenocortical neoplasm after a 2 years follow up

Wagner Clothilde , Mansour Sarah , Racolta Niculina , Keller Philippe , Rao Pramod , Marie-Claire Tortel , Lindner Veronique , Smagala Agnes

Oncocytic adrenocortical neoplasms (OAN) were first described by Kakimoto et al. in 1986. Since then, only 160 cases have been reported in the literature. There are 3 categories of OANs: pure oncocytic, mixed oncocytic and ordinary adrenocortical with focal oncocytic changes. Although the majority of OANs are considered benign tumors, certain OANs may present similar characteristics to adrenocortical carcinoma, correct histological caractherisation is therefore crucia...

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ea0073aep56 | Adrenal and Cardiovascular Endocrinology | ECE2021

Paraganglioma in pregnancy: The need for a multidisciplinary approach

Elvas Ana Rita , Bárbara Araújo , Couto Joana , Martins Raquel G. , Paiva Sandra , António Lobo , Santos Fernando , Paiva Isabel , Rodrigues Fernando

IntroductionParagangliomas (PGL) of the urinary bladder are an extremely rare entity. During pregnancy, PGL can carry higher risk of foetal and maternal mortality, which can be significantly reduced when the diagnosis is made antepartum and adequate multidisciplinary management and surveillance is started. However, despite clinical stability, delivery complications rates are still higher than in the general obstetric population.Cas...

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ea0073aep57 | Adrenal and Cardiovascular Endocrinology | ECE2021

The prevalence of metabolic and cardiovascular complications in patients with pheochromocytoma

Abidi Sahar , Khessairi Nadia , Jemaa Marwa Ben , Grira Wafa , Chaker Fatma , Chihaoui Melika

IntroductionPhaeochromocytomas are rare neuroendocrine tumors secreting high levels of catecholamines, able to exert serious metabolic and cardiovascular effects. Glucose intolerance are common complications that require an early recognition and treatment.MethodsA retrospective study was conducted to assess the prevalence of metabolic and cardiovascular complications in 35 patients diagnosed with pheochromocy...

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ea0073aep58 | Adrenal and Cardiovascular Endocrinology | ECE2021

Diabetes and adrenal incidentaloma

Jemaa Marwa , Khessairi Nadia , Abidi Sahar , Chaker Fatma , Grira Wafa , Chihaoui Melika

The term adrenal incidentaloma is referring to an adrenal mass discovered incidentally during an abdominal imaging exam not motivated by the exploration of an adrenal pathology. The prevalence of diabetes in incidentaloma is high therefore a cortisol secretion should be searched. This is a retrospective study conducted on 100 patients with adrenal incidentaloma. These patients are divided into two groups; the first group is made up of diabetics (G1: n = 31...

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ea0073aep59 | Adrenal and Cardiovascular Endocrinology | ECE2021

Computed tomography in diagnosis of non-functional adrenal adenoma

Chzhen Tatyana , Kiseleva Tatyana

BackgroundAdrenal incidentaloma (AI) is an adrenal mass discovered accidentally during abdominal or chest imaging techniques not aimed to adrenal gland assessment. The management of non-functional adrenal adenomas (NFAI) at least 4 cm is still a matter of debate as it is unclear whether imaging can be used to characterize their potential malignancy. Moreover, the risk of new hypersecretion in nonoperated tumors is uncertain. Our aim was to better charact...

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ea0073aep60 | Adrenal and Cardiovascular Endocrinology | ECE2021

Assessment of glucolipid metabolism in patients with nonfunctional adrenal incidentaloma

Li Jie , Zhang Jiaxin , Yang Guimei , Hou Xintong , Yang Dan , Yang Jing , Zhang Yi , Liu Yunfeng

BackgroundsThe study aimed to explore the characteristics of glucolipid metabolism in patients with nonfunctional adrenal incidentaloma(NFAI). And investigate the relationship between these factors and insulin resistance, islet beta cell function.MethodsThis study enrolled eight patients with nonfunctional adrenal incidentaloma and five healthy controls(HCs). These data were recorded including body measuremen...

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ea0073aep61 | Adrenal and Cardiovascular Endocrinology | ECE2021

Cushing’s syndrome induced galactorrhoea in a non - lactating female: clinical case

Klimaite Raimonda , Cyrolyte Saule , Meskinyte Ieva , Valickas Raimondas , Dauksa Albertas , Zilaitiene Birute

IntroductionIt has been observed that in patients with depression and anxiety disorders dopamine secretion is suppressed, therefore prolactin secretion increases. Prolonged hypercortisolemia causes a variety of psycho-emotional changes that may affect dopamine secretion.CaseA 36-year-old woman was admitted to the Hospital of Lithuanian University of Health Sciences Kauno Klinikos due to a 10-year-lasting gala...

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ea0073aep62 | Adrenal and Cardiovascular Endocrinology | ECE2021

Patients with congenital adrenal hyperplasia show an adverse cardiovascular risk profile compared to patients with autoimmune adrenalitis

Hannes Beiglböck , Magdalena Bögl , Fellinger Paul , Metz Matthaeus , Vila Greisa , Luger Anton , Trattnig Siegfried , Kautzky-Willer Alexandra , Krssak Martin , Krebs Michael , Peter Wolf

BackgroundDespite adequate hormone replacement therapy, evidence suggests an increased mortality in patients suffering from primary adrenal insufficiency, mainly because of cardiovascular diseases. Congenital adrenal hyperplasia (CAH) and autoimmune adrenalitis (AI) are two entities with a different pathophysiological background and might therefore show divergent cardiovascular risk profiles.Methods9 patients...

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ea0073aep63 | Adrenal and Cardiovascular Endocrinology | ECE2021

Prognostic factors in Adrenocortical Carcinoma: A single institution case-series

Parianos Christos , Kyriakopoulos Georgios , Kostakis Ioannis D. , Nasiri-Ansari Narjes , Aggeli Chrysanthi , Angelousi Anna , Choreftaki Theodosia , Papavassiliou Athanasios G. , Kaltsas Gregory , Zografos Giorgos , Kassi Evanthia

BackgroundAdrenocortical carcinoma (ACC) is a rare but very aggressive endocrine malignancy with poor survival. Histopathology is important for diagnosis, while in some cases immunohistochemical markers and gene profiling of the resected tumor may be superior to current staging systems to determine prognosis.AimHerein, we aimed to present the 20year experience at a tertiary Hospital in patients with ACCs and ...

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ea0073aep64 | Adrenal and Cardiovascular Endocrinology | ECE2021

The clinical, paraclinical, etiological and therapeutic profile of adrenal incidentalomas

Mouelhi Yasmine , Khessairi Nadia , Madhi Wiem , Yazidi Meriem , Grira Wafa , Chihaoui Melika

ObjectiveDescribe the clinical, paraclinical, etiological and therapeutic profile of adrenal incidentalomas.Material and methodsRetrospective study, conducted on 100 patients previously hospitalized in the endocrinology department of the university hospital center RABTA, following the fortuitous discovery of an adrenal mass over a period of 10 years.ResultsThe mea...

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ea0073aep65 | Adrenal and Cardiovascular Endocrinology | ECE2021

Nephrotic syndrome following resection of an adrenal incidentaloma: A case report

Batool Maria , Leen Eamon , Glavey Siobhan , Sreenan Seamus , Mcdermott John

A 69 year old man had a 5 cm right adrenal lesion discovered incidentally while being investigated for a deterioration in previously well-controlled hypertension. Routine investigations including serum albumin were normal. Further investigation confirmed a non-functioning adrenal lesion. MRI revealed a non-fat-containing T1 hyperintense indeterminate adrenal lesion with speckling of T2 hyperintensity, not typical for adenoma, hyperplasia, myelolipoma, haemangioma or pheo...

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ea0073aep66 | Adrenal and Cardiovascular Endocrinology | ECE2021

Recurrence of a malignant corticosadrenaloma

Pangui Henricia Laurinda , Haraj Nassim Essabah , Aziz Siham El , Chadli Asmaa

IntroductionThe adrenal cortex is a rare malignant tumor at the expense of the adrenal gland, very aggressive because of its invasion, its metastatic potential and its five (5) year survival at 40% with a high risk of locoregional relapse.Case presentationWe report the case of a 17-year-old patient with a history of long-term corticosteroid therapy over 3 years and secondary amenorrhea for 2 years, who was ad...

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ea0073aep67 | Adrenal and Cardiovascular Endocrinology | ECE2021

Diagnosing Cushing’s syndrome due to Ectopic ACTH secretion warrants high Index of Suspicion- phenotypical features may not always present

Siddique Rana , Brahma Anupam

Patients with Cushings syndrome usually have characteristic phenotypical features but this is not always true in case of Ectopic ACTH secretion. This is mainly because this develops more acutely and underlying malignancy can cause significant weight loss. We report a 71 years old male with background of Prostatic malignancy who was found to have new profound hypokalaemia which was resistant to treatment. There were no signs of Cushings syndrome but index of suspici...

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ea0073aep68 | Adrenal and Cardiovascular Endocrinology | ECE2021

Primary hyperaldosteronism. A clinical profile of the disease without arterial hypertension

Kostoglou-Athanassiou Ifigenia , Athanassiou Lambros , Spyropoulos Panagiotis , Xanthakou Eleni , Fortis Athanasios , Kalogirou Thomais , Athanassiou Panagiotis

Primary hyperaldosteronism may be due to an adrenal adenoma and is an increasingly recognized cause of secondary arterial hypertension. The disease causes hypokalemia and is usually treated surgically by excision of the adrenal adenoma. However, it appears that it may present with a clinical profile without arterial hypertension. The aim was to describe three cases of primary hyperaldosteronism who presented with hypokalemia and an adrenal adenoma with normal blood pressure. A...

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ea0073aep69 | Adrenal and Cardiovascular Endocrinology | ECE2021

Quality of life in children diagnosed with non-classic congenital adrenal hyperplasia

Maria João Ferreira , Moita Rita , Borges-Canha Marta , Silva Rita Santos , Ferreira Sofia , Costa Carla , Carvalho Davide , Cíntia Castro-Correia

IntroductionNon-classical congenital adrenal hyperplasia (NC-CAH) is a chronic disease characterized by excessive androgen production. Affected children may have their quality of life negatively affected by the awareness of a medical condition, symptoms of hyperandrogenism and the burden of daily medication administration. Pediatric Quality of Life Inventory 4.0 (PedsQL) is a validated tool to assess health-related QoL (HRQoL).Meth...

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ea0073aep70 | Adrenal and Cardiovascular Endocrinology | ECE2021

Metabolic profile and cardiovascular risk assessment in subclinical cushing’s syndrome

Salah Dhoha Ben , Missaoui Abdelmouhaymen , Elleuch Mouna , Trimeche Oumeyma , Mnif Fatma , Charfi Nadia , Mnif Mouna , Mejdoub Nabila , Faten Hadj Kacem , Mohamed Abid

IntroductionSubclinical Cushings syndrome (SCS) is an endocrine disorder characterized by an autonomous cortisol secretion in patients bearing adrenal adenomas in the absence of specific signs of hypercortisolism. The cortisol excess is known to be associated with metabolic comorbidities such as obesity, hypertension, glucose intolerance, and dyslipidemia increasing the incidence of cardiovascular events. The objective of this study was to describe...

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ea0073aep71 | Adrenal and Cardiovascular Endocrinology | ECE2021

The insulin tolerance test (ITT) in the assessment of the adrenal axis

Abidi Sahar , Grira Wafa , Khessairi Nadia , Oueslati Ibtissem , Yazidi Meriem , Chaker Fatma , Chihaoui Melika

IntroductionThe insulin tolerance test (ITT) is the gold standard for the assessment of the integrity of the hyopothalamo-pituitray adrenal axis. its major drawbacks are the mandatory presence of an experienced physician and continuous supervision to detect any complication. Our study aims to evaluate the indications and the outcomes of the ITT performed in our department.Patients and methodsWe conducte...

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ea0073aep72 | Adrenal and Cardiovascular Endocrinology | ECE2021

Metabolic impact of glucocorticoid substitution in Addison’s disease

Safi Wajdi , Salah Dhoha Ben , Elmoctar Sidina Mohamed , Mohamed Abdallahi Mohamed Ahmed , Charfi Nadia , Mnif Fatma , Rekik Nabila , Mnif Mouna , Kacem Faten Hadj , Abid Mohamed

IntroductionRecent studies in patients with Addisons disease have shown that this condition, even if treated, is fraught with significant morbidity and even excess mortality. The objective of our study was to determine the deleterious effects of long-term glucocorticoid replacement mainly on the metabolic level.MethodsRetrospective study, carried out at the Endocrinology and Diabetology Department of H&...

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ea0073aep73 | Adrenal and Cardiovascular Endocrinology | ECE2021

Late night salivary cortisol and Cushing’s syndrome

ARBI Kawthar El , mnif fatma , Naifar Manel , Zargni Asma , Boujelben Khouloud , Ayadi Fatma Makni , faten hadj kacem , mohamed Abid

IntroductionThe thresholds of late night salivary cortisol (LNSC) vary widely among studies due to differences in assay methodologies and in control groups. We aimed to verify the analytical performance of the LNSC by electrochimiluminescence assay (ECLIA) and to establish cut-off values of LNSC for the screening of Cushings syndrome (CS).MethodsPatients with suspected CS underwent screening tests inclu...

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ea0073aep74 | Adrenal and Cardiovascular Endocrinology | ECE2021

Spontaneous testicular necrosis revealing a pheochromocytoma

Wagner Clothilde , Bouldoires Bastien , Mansour Sarah , Racolta Niculina , Schneider Marc , Smagala Agnes

Pheochromocytoma is a rare tumor of the adrenal medulla, responsible for excessive secretion of catecholamines. Symptoms include the classic triad: headache, palpitations and sweating, usually accompanied by hypertension. We report the case of a pheochromocytoma diagnosed following an episode of testicular necrosis. A 72-year-old patient with history of psoriasis and prostate resection underwent emergency surgery for increased testicular pain suspicious of testicular tumor. Pa...

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ea0073aep75 | Adrenal and Cardiovascular Endocrinology | ECE2021

Bilateral pheochromocytoma in von hippel-lindau syndrome revealed by a hemangioblastoma

Kamoun Elyes , Rojbi Imen , Laamouri Rihab , Majdoub Marwa , Besrour Chayma , Lakhoua Youssef , Mchirgui Nadia , Nacef Ibtissem Ben , Khiari Karima

IntroductionVon Hippel-Lindau (VHL) syndrome is an autosomal dominant disease resulting in a susceptibility to develop central nervous system and retinal hemangioblastomas, endolymphatic sac tumors, renal clear cell carcinoma and pheochromocytoma. Pheochromocytoma occurs usually at a younger age and tends to be bilateral in VHL syndrome. Herein, we describe a case of VHL syndrome with cerebellar hemangioblastoma, bilateral pheochromocytoma and kidney tum...

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ea0073aep76 | Adrenal and Cardiovascular Endocrinology | ECE2021

Quality of life in patients with classical form of congenital adrenal hyperplasia- deficiency of 21 hydroxylase

Vrbikova Jana , Jitka Prajsova , Dragomirecka Eva

Literary data concerning quality of life in adult patients with classical form of 21 hydroxylase deficiency (21 CAH) are sparse and discrepant. Our aim thus was to explore quality of life in a group of young adults with 21CAH attending regularly tertiary reference care centre. We used WHOQuOL Bref questionnaire and we administered it to 45 21 CAH patients of age 28.6 ± 8 yrs and we compared the results with the data from 111 age matched controls from healthy Czech populat...

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ea0073aep77 | Adrenal and Cardiovascular Endocrinology | ECE2021

Hyperthermia differentially affects cortisol and aldosterone secretion under stimulated conditions

Donlon Padraig , Mullen Nathan , Warde Kate , Bottiglieri Anna , Cappiello Grazia , Farina Laura , Basel Matthew , Martin O’Halloran , Prakash Punit , Paula O’Shea , Dennedy Michael Conall

IntroductionPrimary Aldosteronism (PA) is the commonest secondary cause of hypertension. Mainstay therapy, adrenalectomy resects both hypersecreting and adjacent normal tissue. It is therefore only suitable for patients with unilateral disease (40% cases), whom are surgical candidates. Thermal therapy presents a plausible minimally invasive therapy, to target and disrupt hypersecreting aldosterone producing adenomas (APA), while also preserving adjacent ...

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ea0073aep78 | Adrenal and Cardiovascular Endocrinology | ECE2021

Bilateral adrenal leiomyoma mimicking adrenal malignancy: A rare case report

Jajah Mohammad Bilal , Hassan Asim , Elamin Mohammed Haj , Almalki Abdulkareem

BackgroundAdrenal leiomyoma is a rare benign soft tissue tumor, it is even more unusual if presenting bilaterally; 21 cases have been reported in the literature and only six had bilateral involvement; 5 in the pediatric population and only one in an adult patient. Radiological appearance may frequently be confused with malignancy especially if large, calcified and with central necrosis. We report a rare case of bilateral, large, calcified, non-functionin...

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ea0073aep79 | Adrenal and Cardiovascular Endocrinology | ECE2021

Hypokalemia in a patient with severe SARS-CoV-2 infection

Ifigenia Kostoglou Athanasiou , Nikolakopoulou Sofia , Konstantinou Alexandra , Athanassiou Lambros , Spyrantis Alexandros , Olga-Maria Spyropoulou , Mascha Olga , Samaras Charilaos , Bliziotis Ioannis , Athanassiou Panagiotis

Hypokalemia has been observed in cases of the new SARS-CoV-2 infection. It has been suggested that hypokalemia may be a sensitive biomarker of disease severity and the requirement for invasive mechanical ventilation requirement in COVID-19 pneumonia. The aim was to describe the case of a patient with severe SARS-CoV-2 pneumonia who developed severe hypokalemia. A patient, male, aged 52, presented with fever and dry cough. He was found to be positive for the SARS-CoV-2 infectio...

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ea0073aep80 | Adrenal and Cardiovascular Endocrinology | ECE2021

A giant nonfunctioning adrenocortical carcinoma: A case report

Besrour Chayma , Rojbi Imen , Majdoub Marwa , Laamouri Rihab , Kamoun Elyes , Lakhoua Youssef , Mchirgui Nadia , Nacef Ibtissem Ben , Khiari Karima

IntroductionThe adrenocortical carcinoma(ACC) is a rare malignant tumor arising from the adrenal cortex, it is usually associated to abnormal hormone secretion, but sometimes it is nonfunctioning, leading to a delayed diagnosis with a locally advanced and/or a metastatic disease. ObservationWe report the case of a 42 year-old woman with no medical history who consulted for chronic epigastralgia. On physical e...

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European Congress of Endocrinology 2021

BiosciAbstracts