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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Audio Eposter Presentations

Calcium and Bone

ea0073aep81 | Calcium and Bone | ECE2021

Bone consequences of high dose denosumab to treat an aneurysmal bone cyst, an example of the European Reference Network support

Sindaco Giulia Del , Berlanga Pablo , Brugieres Laurence , Thebault Eric , Mantovani Giovanna , Wicart Philippe , Agnès Linglart

Aneurysmal bone cysts (ABCs) are rare pseudotumoral bone lesions with potential aggressive behavior due to the extensive destruction of surrounding bone. Besides surgery, denosumab has been investigated as a treatment for benign fibro-osseous lesions. As for ABCs, pediatric experience is limited, reporting mainly beneficial effects on lesions growth and associated pain. Some reports included well known side effects associated with denosumab, such as the rebound hypercalcemia a...

ea0073aep82 | Calcium and Bone | ECE2021

Correlation between parathyroid adenoma volume and markers of calcium-phosphate metabolism in patients with primary hyperparathyroidism

Yankova Inna , Ivanova Gergana , Shinkov Alexander , Kovatcheva Roussanka

IntroductionIn primary hyperparathyroidism (PHPT) the chronic overproduction of parathormone (PTH) is mostly due to a solitary adenoma.AimThe aim of our study was to examine the relationship between calcium-phosphate metabolism and the volume of the parathyroid adenoma (PTA) in patients with PHPT.Material and methodsThe study included 195 patients with biochemical...

ea0073aep83 | Calcium and Bone | ECE2021

Efficacy and safety of long-term treatment with monthly calcifediol soft capsules in vitamin D deficient patients

Esteban Jódar , Perez-Castrillon Jose Luis , Antonio Dueñas , Hernandez Gonzalo , Fernandez Nieves , Sandra Pamela Chinchilla Gallo

BackgroundVitamin D has shown to play a role in multiple diseases due to its skeletal and extraskeletal actions (such as immunomodulation). In this sense, vitamin D deficiency has become a worldwide health issue. Few supplementation guidelines mention calcifediol treatment, its optimal dosing and treatment duration, despite being the direct precursor of calcitriol and the biomarker of vitamin D status.Objectives<p class="abstex...

ea0073aep84 | Calcium and Bone | ECE2021

Non-nuclear cataracts in hypoparathyroidism are associated with biochemical control of the disease

Zavatta Guido , Tebben Peter , Clarke Bart L.

IntroductionA high calcium-phosphate product is thought to increase the risk of soft tissue calcification in hypoparathyroidism, including cataracts. Based on small case series, cataracts in hypoparathyroidism typically develop in the posterior subcapsular region of the lens. However, the mechanism of cataract formation is still not well understood.Materials and methodsIn a large cohort of 1014 patients with ...

ea0073aep85 | Calcium and Bone | ECE2021

Total and free vitamin D metabolites in female primary hyperparathyroidism patients

Meng Lingqiong , Su Chi , Shapses Sue A , Wang Xiangbing

BackgroundPrimary hyperparathyroidism (PHPT) is a common endocrine disorder accompanied by low total 25-hydroxyvitamin D [25(OH)D] levels. The 25(OH)D is converted to its biologically active form, 1.25-dihydroxyvitamin D [1.25(OH)2D] that then circulates as bound or free forms. Free 1.25(OH)2D concentrations in patients with PHPT have not previously been examined and understanding this is important to better assess vitamin ...

ea0073aep86 | Calcium and Bone | ECE2021

A rare case of hypercalcemia in pregnancy- a diagnostic conundrum

Ladha Tasneem , Moriarty Maura , Khan Shaila , Tan Min Yi , Vakilgilani Tannaz , Bravis Vassiliki , Sykes Lynne , Yu Christina , Comninos Alexander , Cox Jeremy , Robinson Stephen , Agha-Jaffar Rochan

Hypercalcaemia in pregnancy is a rare but important finding, given the associated potential risks to mother and baby. These include hypertension, pancreatitis, nephrolithiasis and renal failure in the mother and intrauterine growth restriction, neonatal hypoparathyroidism/hypocalcaemia and stillbirth in the baby (1). We present the case of a 26-year-old female with a background of PTH-independent hypercalcaemia of unknown aetiology. This was initially detected at age 6 months ...

ea0073aep87 | Calcium and Bone | ECE2021

Effect of parathyroidectomy on early diastolic dysfunction assessed with ventricular mass index in patients with primary hyperparathyroidism

Tzikos Georgios , Manani Christina , Chorti Aggeliki , Evaggelos Sykaras , Boura Evangelia , Adamidou Foteini , Pliakos Ioannis , Papavramidis Theodosios S.

IntroductionPrimary hyperparathyroidism (PHPT) is characterized by excessive secretion of parathyroid hormone (PTH) from one or more parathyroid glands. PTH has a central role in the regulation of calcium and phosphate and the classic disorder causes primarily hypercalcemia associated with renal and bone manifestations. Non-classical symptoms are also present including cardiovascular, gastrointestinal, psychiatric, neuro-cognitive disorders. Regarding ca...

ea0073aep88 | Calcium and Bone | ECE2021

Bone mineral density evolution following long-term simultaneous pancreas-kidney transplantation in type 1 diabetes

Sílvia Santos Monteiro , Santos Tiago Silva , Duarte Diana Borges , Pereira Catarina , Silva Filipa , Martins La Salete , Dores Jorge

IntroductionSimultaneous pancreas-kidney transplantation (PKT) has a beneficial effect on the evolution of chronic complications in type 1 diabetic (T1D) patients with terminal chronic kidney disease (CKD). However, the CKD-mineral and bone disorder (CKD-MBD) remains a frequent complication. There are a few studies addressing the long-term evolution of bone mineral density (BMD) in these patients.AimTo charac...

ea0073aep89 | Calcium and Bone | ECE2021

Normalization of SIAD-induced hyponatremia stimulates osteoblast function

Potasso Laura , Refardt Julie , Meier Christian , Christ-Crain Mirjam

BackgroundHyponatremia is associated with increased risk of bone fragility and fractures. In vitro studies suggest a role of hyponatremia in stimulating osteoclast activation, whereas other studies rather revealed a possible role of acute hyponatremia in impairing osteoblast function. We aimed to assess whether and how correction of hyponatremia in hospitalized patients with the syndrome of inappropriate antidiuresis (SIAD) has an impact on bone...

ea0073aep90 | Calcium and Bone | ECE2021

Fibrosis 4 score is associated with bone density measures in postmenopausal women

Armeni Eleni , Augoulea Areti , Paschou Stavroula , Palaiologou Anastasia , Kaparos Georgios , Panoulis Konstantinos , Lambrinoudaki Irene

IntroductionThe routine assessment of postmenopausal women involves screening for cardiometabolic risk factors and bone health. Evaluation of the liver function is not commonly performed, even though this could be easily performed with the use of indirect markers, such as the Fibrosis 4 score. Recent evidence supports an association between liver cirrhosis and bone turnover, affecting both the trabecular and the cortical bone. Therefore, we aimed to expl...

ea0073aep91 | Calcium and Bone | ECE2021

Primary hyperparathyroidism: Differences in presentation between older and younger patients

Kozamernik Katarina Mlekus , Jensterle Mojca , Luka Ležaic´ , Marko Hocˇevar , Jazbinsek Soncka , Remec Katarina , Janez Andrej , Tomaž Kocjan

IntroductionThe incidence of primary hyperparathyroidism (PHPT) increases with age; however, the clinical presentation might change with aging. We aimed to compare the clinical presentation of older and younger patients with PHPT.MethodsWe retrospectively analyzed the biochemical status, renal involvement, and bone mineral density (BMD) of patients who were diagnosed with PHPT at our endocrine clinic from 200...

ea0073aep92 | Calcium and Bone | ECE2021

Primary hyperparathyroidism – a contemporary picture based on 100 patients from the last decade

Boyanov Mihail , Bakalov Deniz , Karamfilova Vera , Gateva Antoaneta , Assyov Yavor , Zaharieva Emanuela , Atanasova Kirilina , Sheinkova Galina , Tsakova Adelina , Kamenov Zdravko

Primary hyperparathyroidism (PHPT) is being more and more frequently diagnosed.Objectiveto describe the clinical presentation and the main laboratory and imaging findings in a group of patients with PHPT diagnosed during the last 10 years. Materials and Methods: This was a retrospective cross-sectional study with data review from the last 10 years. Secondary causes for elevated PTH were excluded. The symptoms and signs of hypercalc...

ea0073aep93 | Calcium and Bone | ECE2021

Quantifying the real-world clinical and economic burden of chronic hypoparathyroidism on secondary care in England: A multi-arm, retrospective cohort study

Gittoes Neil , Iqbal Kamran , Marelli Claudio , Vintderdag Helene , Zouraq Ismail Azzabi , Were Jay , Dass Nin

BackgroundChronic hypoparathyroidism (hypoPT) predisposes patients to comorbidities such as cardiovascular/cerebrovascular disease, infection, mental illness, and renal impairment often associated with an increased burden to healthcare systems. Suboptimal disease control is common with standard therapy. The objective of this study was to quantify and assess differences in the clinical and economic burden on secondary care among patients with post-surgica...

ea0073aep94 | Calcium and Bone | ECE2021

’Primary hyperparathyroidism: Relationship between localisation of adenoma and calcium level’

Khan Huma , Wills Alice , Aung Theingi

AimTo assess relationship between serum calcium level and localization studies and management outcome.MethodologyRetrospective analysis of data for patients referred by primary care for hypercalcemia from 1/3/2019 to 1/3/2020 to the Endocrinology department at Royal Berkshire Hospital. The sample size was 63 which excluded normo-calcemic hyperparathyroidism as well as MEN1/2 patients.Re...

ea0073aep95 | Calcium and Bone | ECE2021

High dose short term glucocorticoid (gc) treatment seems to have no long term negative effect on bone mineral density (bmd) of newly diagnosed multiple sclerosis (ms) patients

Simeakis George , Saltiki Katerina , Fakas Nikolaos , Koutsikos John , Athanasiou Kostas , Papatheodorou George , Papatheodorou Athanasios , Zapanti Evangelia , Anagnostouli Maria , Alevizaki Maria , Terpos Evangelos

ObjectivesHigh-Dose-Intravenous-Steroid-Treatment-(HDIST) represents the first choice of treatment for MS relapses. Although chronic oral GC-administration is associated with bone loss there are still conflicting data regarding HDIST. Methods25 newly-diagnosed MS-patients (10-women) were prospectively enrolled meeting the following eligibility criteria: age 18–45 yrs, fully ambulatory, women with normal ...

ea0073aep96 | Calcium and Bone | ECE2021

Normocalcemic primary hyperparathyroidism – an early stage of hypercalcemic hyperparathyroidism?

Bárbara Filipa Araújo , Ferreira Sara Esteves , Rodrigues Teresa , Cátia Andreia Araújo , Lúcia Fadiga , Paiva Sandra , PAIVA Isabel

IntroductionPrimary hyperparathyroidism (PHPT) is a common endocrine disorder and classically associated with hypercalcemia (HHPT). There is a newest variant of PHPT, defined by normal albumin-corrected calcium levels - normocalcemic PHPT (NHPT) – which may represent an early stage of HHPT. Nevertheless, there is limited data on how this variant presents clinically and biochemically.AimTo evaluate the de...

ea0073aep97 | Calcium and Bone | ECE2021

Osteoporosis and prevalent vertebral fractures are associated with insulin resistance in non-diabetic postmenopausal women

Armeni Eleni , Augoulea Areti , Paschou Stavroula , Soureti Anastasia , Kaparos Georgios , Rizos Dimitrios , Antoniou Aris , Panoulis Konstantinos , Lambrinoudaki Irene

IntroductionRecent evidence suggests a possible link between prediabetes and lower density in postmenopausal populations. Moreover, earlier data suggest a link between diagnosis of diabetes and lower levels of bone density in women after the menopausal transition. We aimed to evaluate the possible association between insulin resistance and a diagnosis of lumbar or hip osteoporosis and/or prevalent fractures of the lumbar spine. Met...

ea0073aep98 | Calcium and Bone | ECE2021

The bone impact of body composition, adipokines and FGF23-Klotho axis in active acromegaly

Bilha Stefana , Matei Anca , Constantinescu Daniela , Pavel-Tanasa Mariana , Mogos-Cioncu Raluca , Cianga Petru , Preda Cristina , Branisteanu Dumitru D.

IntroductionBody composition (BC), adipokines and the fibroblast growth factor-23 (FGF23) - Klotho axis interfere with bone metabolism and also suffer important modifications in acromegaly. We aimed to investigate their influence upon bone in active acromegaly, compared to controls.MethodsWe performed a cross sectional study, investigating the adipokines (leptin, adiponectin, resistin) secretion pattern, BC p...

ea0073aep99 | Calcium and Bone | ECE2021

Recurrent primary hyperparathyroidism due to ectopic retropharygeal adenoma

Mouna Guermazi , Mouna Snoussi , Abir Derbel , Feten Frikha , Chifa Dammak , Salah Raida Ben , Sameh Marzouk , Zouhir Bahloul

IntroductionThe ectopic parathyroid adenoma (EPTA) is the most common cause of failed parathyroid surgery. Most often localisations are intra-thymic and intra-mediastinal adenomas. We report a rare presentation of a symptomatic parathyroid adenoma located in ectopic retropharyngeal position diagnosed after surgical treatment of primary hyperparathyroidism (PHPT).ObsevationA 42-year-old female was referred to ...

ea0073aep100 | Calcium and Bone | ECE2021

Denosumab rebound effect associated with breast cancer recurrence – a coincidence? Case report

Zajickova Katerina , Kasalicky Petr

Denosumab discontinuation leads to loss of bone mineral density (BMD) achieved with treatment and in some patients to multiple vertebral fractures (VFx). Beyond bone, antiresorptive agents such as denosumab may affect breast cancer biology. We report a 69-year-old woman treated with the aromatase inhibitor anastrazole for breast cancer who suffered from five spontaneous vertebral fractures after denosumab cessation. Initially, she received four years of ibandronate followed by...

ea0073aep101 | Calcium and Bone | ECE2021

Association of preoperative factors and postoperative hypocalcemia after parathyroidectomy for primary hyperparathyroidism

Aynetdinova Alina , Eremkina Anna , Olga Yu. Rebrova , Kovaleva Elena , Mokrysheva Natalia

BackgroundParathyroidectomy (PTE) is the basic treatment for symptomatic primary hyperparathyroidism (PHPT). It is also recommended for some asymptomatic patients. However, PTE can be followed by some complications such as postoperative hypocalcemia.AimTo evaluate association of demographic, clinical, laboratory factors, preoperative cholecalciferol supplementation and hypocalcemia after PTE in patients with ...

ea0073aep102 | Calcium and Bone | ECE2021

Which patients with primary hyperparathyroidism were not referred for surgery? A single-center experience

Jaksic Vlatka Pandzic , Majic Ana , Andric Jelena , Zrilic Anamarija , Oreski Ivan , Gulin Petar , Boscic Drago , Marusic Srecko

Although primary hyperparathyroidism (PHPT) can be successfully cured by parathyroidectomy (PTX) and indications for surgery are well defined, a considerable number of patients do not get operated on. By evaluating referrals for PTX in our academic hospital, we might improve our approach to the care of these patients. We retrospectively reviewed patients’ hospital records with newly diagnosed PHPT between 2014 and 2020. Biochemical and clinical parameters along with resul...

ea0073aep103 | Calcium and Bone | ECE2021

F18-choline PET/CT for primary hyperparathyroidism localization

Lobo Ines , Rojas Patricia Martin , Paola Parra Ramírez , Oscar Moreno Dom&237;nguez , Cristina Álvarez Escolá

ObjectiveSurgery is the only curative treatment for primary hyperparathyroidism. Minimally invasive parathyroidectomy is superior in terms of cure and complication rates and is less costly than inpatient bilateral cervical exploration. Preoperative localization of parathyroid adenoma by imaging is a requirement for outpatient minimally invasive surgery. One of the most frequently used imaging techniques for parathyroid adenoma localization is Tc99m-sesta...

ea0073aep104 | Calcium and Bone | ECE2021

Evaluation of bone quality by dxa-based bone strain index in primary hyperparathyroidism

Tabacco Gaia , Naciu Anda Mihaela , Messina Carmelo , Rinaudo Luca , Cesareo Roberto , Falcone Stefania , Manfrini Silvia , Napoli Nicola , Bilezikian John , Ulivieri Fabio Massimo , Palermo Andrea

BackgroudPrimary hyperparathyroidism (PHPT) is associated with impaired bone quality and increased fracture risk. Reliable tools for the evaluation of bone quality parameters are not yet clinically available. Bone Strain Index (BSI) is a new metric for bone strength based on Finite Element Analysis from lumbar spine and femoral neck dual X-ray absorptiometry images.AimTo assess the lumbar spine (LS), femoral ...

ea0073aep105 | Calcium and Bone | ECE2021

Ectopic parathyroid hormone as a rare aetiology of hypercalcemia with rhabdomyosarcoma: A new treatment strategy with Zoledronic Acid and Denosumab

Kilci Fatih , Demirsoy Ugur , Jones Jeremy H , Cizmecioglu-Jones Filiz Mine

IntroductionParaneoplastic hypercalcemia is extremely rare in the pediatric population, requiring urgent treatment. Pediatric malignancy-related hypercalcemia (PMRH) has been associated with rhabdomyosarcoma (RMS). Hypercalcemia with elevated parathyroid hormone (PTH), ectopic PTH secretion, is rarer (< 1% of cases). Reports of the use of Zoledronic Acid (ZA) as a second line bisphosphonate are limited. The monoclonal antibody, Denosumab, which inhib...

ea0073aep106 | Calcium and Bone | ECE2021

Mineral and bone disorders in patients after combined kidney-pancreas or kidney transplantation

Maganeva Irina , Larina Irina , Severina Anastasia , Aynetdinova Alina , Eremkina Anna , Shamkhalova Minara , Mokrysheva Natalia

BackgroundThe kidney or kidney-pancreas transplantation corrects many of the metabolic or biochemical abnormalities associated with chronic kidney disease (CKD); however, mineral bone disease (MBD) and cardiovascular pathology remain frequent in transplant recipients. This happens especially in patients who have long history of secondary hyperparathyroidism (SHPT), as well immunosuppressive therapy plays an important role in the progression of MBD.<p...

ea0073aep107 | Calcium and Bone | ECE2021

New variant of the casr gene (c.2459c > t) associated with primary hypoparathyrodism – a case report

Lavrador Mariana , Lages Adriana , Bárbara Araújo , Luísa Barros , Paiva Isabel

BackgroundAutosomal dominant hypocalcaemia, caused by either inherited or de novo mutations in calcium-sensing receptor gene (CASR), is biochemically characterized by the presence of hypocalcaemia, hypercalciuria and inappropriately low levels of PTH. Receptor-activating mutations induce an increase sensitivity to calcium by parathyroid and renal cells, leading to suppression of PTH synthesis and consequently hypocalcaemia. Clinical manifestations are va...

ea0073aep108 | Calcium and Bone | ECE2021

PET/CT with 11C-methionine in the diagnosis of primary hyperparathyroidism

Pogosian Karina , Karonova Tatiana , Yanevskaya Liubov , Berkovich Gleb , Tsoy Uliana , Ryzhkova Daria , Grineva Elena

BackgroundPrimary hyperparathyroidism (PHPT) is the third most common endocrine disorder mainly caused by a single parathyroid adenoma. The localization of the parathyroid adenoma is useful for increasing the recovery rate of PHPT, and reducing the complication rate. Conventional localization techniques include neck ultrasound, Tc99m-MIBI-SPECT and CT. However, each one of those has its limitations; particularly in cases of ectopic, or multiple parathyro...

ea0073aep109 | Calcium and Bone | ECE2021

Frequency of metabolic syndrome in Paget’s disease of bone

Erol Selvinaz , Sen Esra Cil , Ozturk Feyza Yener , M. Masum Canat , Alayci Birkan , Altuntas Yuksel

ObjectiveScanty data about glucose metabolism, hypertension and metabolic syndrome (MS) have been reported in Paget’s disease of bone (PDB) to be related with increased cardiovascular mortality. We aimed to determine prevalence of metabolic syndrome in PDB and to determine the relationship between metabolic syndrome and bone-specific alkaline phosphatase levels.Patients and methodsTwenty three patients w...

ea0073aep110 | Calcium and Bone | ECE2021

Is necessary long-term follow-up of all patients with primary sporadic hyperparathyroidism undergoing parathyroidectomy?

Castro Ana , Cruz Andrea , Rocío Revuelta , Vicente Almudena , Sastre Julia , Castro Enrique , Mollejo Manuela , Carrasco Miguel

IntroductionPost parathyroidectomy cure in primary hyperparathyroidism (PHPT) is defined as normocalcemia six months after surgery. The frequency of persistent or recurrent post-surgical disease according to lengthy follow-up studies varies between 1% and 14%.ObjectiveTo determine if there is a subset of patients with cure criteria 6–12 months after parathyroidectomy that would not require long-term foll...

ea0073aep111 | Calcium and Bone | ECE2021

The challenge of genetic workup in hypercalcaemia suspected hyperparathyroidism

Ellingham Hana , Albor Christo , Ibrahim Hassan , Hussain Ayaz , Hasnain Solat , Bashir Jawad

The commonest cause of hypercalcaemia is primary hyperparathyroidism (PHPTH). The diagnostic work up includes paired blood samples for serum corrected calcium, parathyroid hormone (PTH) and vitamin D levels. But in young patients, rare genetic conditions could be contributing towards hypercalcaemia and hence could produce a diagnostic challenge. We report hypercalcaemia work up in two young females where genetic tests were required.Case 1<p class="ab...

ea0073aep112 | Calcium and Bone | ECE2021

4D-CT – is it useful in Hyperparathyroidism?

Ivo Catarina , Vitória Duarte , David Veríssimo , João Silva , Luís Lopes , Passos Dolores , João Jácome de Castro , Marcelino Mafalda

IntroductionPrimary Hyperparathyroidism (PHPT) results from one or more parathyroid glands hyperfunction. It is recommended that the preoperative location of the parathyroid lesion be performed with cervical ultrasonography and sestamibi-scintigraphy. Recently 4-Dimensional Computed Tomography (4D-CT) has revealed anatomic, morphologic and functional precision for detecting those lesions, either for typical or ectopic location. This study evaluates the d...

ea0073aep113 | Calcium and Bone | ECE2021

The effect of food supplement with calcium and vitamin D3 administration on calcium homeostasis and falls incidence in patients with high fracture risk undergoing medical rehabilitation

Marchenkova Larisa , Vasileva Valeriia

BackgroundVitamin D and calcium deficiencies is of particular importance in older patients undergoing medical rehabilitation and having a high risk of fractures. Preventing falls and fractures, including during the course of rehabilitation, is an important challenge that can be addressed in these patients, in particular through improved nutrition and vitamin D and calcium supplementation.ObjectivesTo evaluate...

ea0073aep114 | Calcium and Bone | ECE2021

Vitamin D deficiency is a key element in COVID-19 hypocalcemia

Filippo Luigi Di , Allora Agnese , Formenti Anna Maria , Castellino Laura , Perticone Francesca , Locatelli Massimo , Frara Stefano , Giustina Andrea

Hypocalcemia has been recently identified as a major biochemical distinctive feature of COVID-19, predicting poor clinical outcomes. Besides the calcium-dependent viral mechanisms of action and the enhanced cellular permeability to calcium ions, we previously hypothesized that hypovitaminosis-D could be a predisposing factor to hypocalcemia. Actually, high prevalence of vitamin D (VD) deficiency in COVID-19 patients (pts) was reported by several studies, but, to date, only few...

ea0073aep115 | Calcium and Bone | ECE2021

Transient hypocalcaemia and definitive hypoparathyroidism after total thyroidectomy in Graves’ disease

Bruno Bouça , Amaral Sara , Vasques Miguel , Monteiro Nuno , Crespo Ana , José Coutinho , Tavares Paula , Bogalho Paula , José Silva-Nunes

IntroductionHypocalcaemia is a complication of total thyroidectomy (TT) and may be more frequent in patients with Graves’ disease. The reason for this increased risk is unclear and its occurrence has been associated with: ophthalmopathy severity, preoperative calcaemia and reimplantation of parathyroid glands.ObjectivesTo evaluate the risk factors for transient hypocalcaemia (TH) and definitive hypoparat...

ea0073aep116 | Calcium and Bone | ECE2021

European Registries for Rare Endocrine Conditions (EuRRECa): The use of an e-reporting tool for registering calcium and phosphate conditions

Ana Luisa Priego Zurita , Bryce Jillian , Ali Salma Rashid , Diana-Alexandra Ertl , Grasemann Corinna , Haeusler Gabriele , Rejnmark Lars , Ahmed Faisal , Natasha-Appelman Dijkstra , Agnès Linglart

IntroductionThe European Registries for Rare Endocrine Conditions (EuRRECa) project was launched in February 2018 and aims to support the needs of the endocrine and bone community by facilitating the collaboration between patients, health care professionals and researchers across Europe and beyond. It is closely linked to the European Reference Networks on Rare Endocrine Conditions (Endo-ERN) and Rare Bone Diseases (ERN BOND) with its registry EuRR-Bone....

ea0073aep117 | Calcium and Bone | ECE2021

Skeletal and bone defects in Turner syndrome

Bouichrat Nisrine , Najoua Messaoudi , Karrou Marouan , Mahroug Ikram , Rouf Siham , Latrech Hanane

IntroductionTurner syndrome is one of the most common chromosomal disorders, with a reported prevalence of 1/2500 live females. It is characterized by short stature, ovarian failure, malformative, autoimmune, skeletal and bone abnormalities. The objective of our work is to study the prevalence of skeletal and bone malformations in our Turnerian patients.Material and methodThis is a retrospective descriptive s...

ea0073aep118 | Calcium and Bone | ECE2021

A retrospective review of the management of skeletal effects following thyroid stimulating hormone suppression therapy (tshst) in patients treated for differentiated thyroid carcinoma (dtc)

Beeharry Deepa , Ahmed Simra , Sharma Dushyant

BackgroundThyrotropin Stimulating Hormone Suppression Therapy (TSHST) in Differentiated Thyroid cancer (DTC) patients can result in reduced bone mineral density (BMD) which is a potential serious problem [1]. Studies on the effects of TSHST on BMD have demonstrated conflicting results [2–5]. There is insufficient guidance regarding the degree and duration of TSHST in the context of skeletal effects despite multiple existing guidelines.<p class="...

ea0073aep119 | Calcium and Bone | ECE2021

Interest of the ’single photon emission tomography computed tomography’ in an atypical location of a parathyroid adenoma

Masmoudi Mohamed , Hasnaoui Mehdi , Lahmar Rihab , Guizani Rihab , Khalifa Mighri

ObjectiveIllustrate the interest of imaging: Single photo emission tomography or Computed tomography in the topographic diagnosis of parathyroid adenomas.ObservationA 67-year-old man, with renal lithiasis presenting a clinical-biological picture of primary hyperparathyroidism with renal bone and colic pain. PTH was 463.2 pg/ml, calcemia 3.4 mmol/l. Cervical ultrasound objectified a lesion suspected of parathy...

ea0073aep120 | Calcium and Bone | ECE2021

An unusual case of primary hyperparathyroidism due to hyperplasia resembling tertiary hyperparathyroidism

Mantega Michele , Mateen Abdul , Azam Sultana , Sharma Bhavna , Seechurn Shivashankar , Remedios Denis , Moonim Mufaddal , DiMarco Aimee , Rahman Mushtaqur

Primary hyperparathyroidism is a common endocrine condition; 80% due to a parathyroid adenoma. We present an unusual case of a 69-year old white European female, who presented first in 2012 with mild hypercalcaemia (< 2.8 mmol/l), osteoporosis, hypertension and type 2 diabetes. Pharmacotherapy included Bendroflumethiazide, but no phosphate supplements. Investigations revealed primary hyperparathyroidism and dual-modality scanning showed no evidence of an adenoma, although ...

ea0073aep121 | Calcium and Bone | ECE2021

The endocrine effects of lithium treatment. Report of a case

Ifigenia-Kostoglou Athanassiou , Giannopoulos Georgios , Athanassiou Lambros , Nomikos Alexandros , Fortis Athanasios , Kalogirou Thomais

Lithium is considered a mainstay treatment option for the management of bipolar affective disorder. However, lithium administration is characterized by endocrine effects. The aim was to present the case of a patient who was on treatment with lithium for many years for the management of bipolar affective disorder and presented with a large parathyroid adenoma causing clinical hyperparathyroidism with severe hypercalcemia who was successfully treated by surgical excision of the ...

ea0073aep122 | Calcium and Bone | ECE2021

Ectopic parathyroid adenomas: where to find them?

Reza Mahin , Hasnain Solat , Albor Christo , Hussain Ayaz , Ibrahim Hassan , Bashir Jawad

Hypercalcaemia due to primary hyperparathyroidism (PHPTH) is fully curable by parathyroidectomy. Occasionally recurrent hypercalcemia presents as a results of either residual adenoma, recurrent disease or an ectopic parathyroid gland. The most challenging cases are those with ectopic glands which are not identified on usual surgical neck exploration. We present a similar case that went through multiple surgeries for recurrent hypercalcemia. A 79-year-old lady initially was dia...

ea0073aep123 | Calcium and Bone | ECE2021

Prevalence, characteristics, and associated factors of Fahr’s syndrome in permanent hypoparathyroidism

Cherchir Faten , Oueslati Ibtissem , Yazidi Meriem , Boukriba Seif , Chaker Fatma , Mizouni Habiba , Chihaoui Melika

IntroductionFahr’s syndrome (FS) is a rare neurodegenerative disorder. It’s characterized by abnormal calcifications in basal ganglia and cerebral cortex inducing neuropsychiatric disorders and cognitive impairment. The aim of our study was to assess the prevalence of FS, its characteristics, and its associated factors in patients with permanent hypoparathyroidism.MethodsWe conducted a cross-section...

ea0073aep124 | Calcium and Bone | ECE2021

The natural history of hypoparathyroidism according to the database of endocrinology research centre

Kovaleva Elena , Eremkina Anna , Aynetdinova Alina , Mokrysheva Natalia

BackgroundHypoparathyroidism is a rare disorder characterized by hypocalcemia and hyperphosphatemia due to absent or inadequate parathyroid hormone secretion. Data on effective treatment strategies and predictors of long-term complications have only recently began to emerge. The epidemiological information regarding chronic hypoparathyroidism in Russia is strictly limited that prompted this research.AimsTo es...

ea0073aep125 | Calcium and Bone | ECE2021

Summer sunshine exposure and vitamin d status in young and middle age poles: is 30 ng/ml Vitamin D cut-off really suitable for the polish population?

Magdalena-Basinska Lewandowska , Lewinski Andrzej , Horzelski Wojciech , Skowronska-Jozwiak Elzbieta

BackgroundThere is no universal consensus regarding vitamin sufficiency status with values either above 20 ng/ml, or 30 ng/ml being quoted as denoting ’sufficient’ status. We have endeavoured to assess the effects of summer sunshine exposure on vitamin D status from a single GP practice in central Poland.Subjects and methodsWe measured concentrations of vitamin D, parathyroid hormone (PTH), creatini...

ea0073aep126 | Calcium and Bone | ECE2021

How frequent is vitamin D toxicity? Data from the national survey of endocrinologists in Russia

Pigarova Ekaterina , Povaliaeva Alexandra , Artem Yu. Zhukov , Glazieva Valentina , Dzeranova Larisa , Rozhinskaya Liudmila , Marova Eugenia , Belovalova Irina , Dedov Ivan

IntroductionClinical guidelines for the prevention and treatment of vitamin D deficiency in adults were formulated and implemented into clinical practice by the Russian association of endocrinologists in 2014. While having multiple health benefits, in some cases, prescribing vitamin D supplements may be accompanied by its toxicity, which has various manifestations and exert potentially dangerous health consequences.Aim<p class=...

ea0073aep127 | Calcium and Bone | ECE2021

Large parathyroid adenomas: unusual clinical characteristics

Anastasia-Konstantina Sakali , Bagias Christos , Thoda Pinelopi , Mparmpa Eleftheria , Pappa Dimitra , Georgiou Eleni , Gountios Ioannis , Tigas Stelios , Bargiota Alexandra

IntroductionThe differential diagnosis between benign and malignant parathyroid neoplasms may be challenging and should always be based on clinical and histological criteria. We are presenting a case series of three patients with clinical, biochemical and imaging findings supporting the presence of a malignant neoplasm but histological findings confirming the diagnosis of a parathyroid adenoma.Case 1A 24-year...

ea0073aep128 | Calcium and Bone | ECE2021

COVID-19 and impaired calcium metabolism upon admission to the hospital

Maganeva Irina , Eremkina Anna , Bibik Ekaterina , Gorbacheva Anna , Kovaleva Elena , Aynetdinova Alina , Mokrysheva Natalia

IntroductionThere is evidence of the interaction between the main parameters of calcium-phosphorus metabolism, vitamin D and the course of a new coronavirus infection. Moreover, hypocalcemia is one of the most frequent biochemical disorders and is associated with severity of the disease, increased likelihood of hospitalization, need for mechanical ventilation, and poor prognosis in COVID-19.ObjectiveTo estima...

ea0073aep129 | Calcium and Bone | ECE2021

CDC73 associated primary hyperparathyroidism and essential tremor

Eliška Svobodová , Rehorkova Pavla , Vcelak Josef , Moravcova Jitka , Havlinova Barbora , Gabalec Filip , Cap Jan

ObjectivePrimary hyperparathyroidism (PHPT) is a common endocrine disorder affecting 2% of the population aged 55 years or older. Primary hyperparathyroidism is due to parathyroid adenoma in about 85% of cases, parathyroid hyperplasia in about 15% of cases, and parathyroid carcinoma in less than 1% of cases. Familial parathyroid disorders are responsible for 10% of the PHPT cases and include among other disorders caused by parafibromin malfunction. Paraf...

ea0073aep130 | Calcium and Bone | ECE2021

The benign course of MEN I disease. Implications for treatment

Athanassiou Lambros , Kostoglou-Athanassiou Ifigenia , Spyropoulos Panagiotis , Xanthakou Eleni , Mascha Olga , Fortis Athanasios , Kalogirou Thomais , Athanassiou Panagiotis

MEN (multiple endocrine neoplasia) I disease represents a compilation of multiple endocrine neoplasms affecting a patient in the course of a life-time. It thus represents a phenotype which has survived over many years. Pituitary neoplasms, lipomas and parathyroid hyperplasia are observed in the disease. The aim was to describe a patient with MEN I disease who presented with lipomas and acromegaly in his early adulthood and developed primary hyperparathyroidism in his senior ye...

ea0073aep131 | Calcium and Bone | ECE2021

Hypercalciuria and associated mineral metabolism disorders in osteopenic/osteoporotic patients: effects of treatment with thiazide diuretics

Nicoli Federico , Dito Giorgia , Guabello Gregorio , Longhi Matteo , Corbetta Sabrina

Hypercalciuria may represent a challenge during the workup for osteoporosis management. The present study aimed: 1) to describe the phenotype associated with hypercalciuria in vitamin D-repleted (serum 25OHD > 20 ng/ml) osteopenic/osteoporotic patients, focusing on kidney, bone and mineral metabolic features; 2) to analyze the effects of thiazides and anti-resorptive drugs on urine calcium excretion (UCa) and mineral metabolism markers. Seventy patients (67 postmenopausal ...

ea0073aep132 | Calcium and Bone | ECE2021

Bone mineral density evolution after Denosumab withdrawal

Mª Rosa Alhambra Expósito , Ana Barrera-Martín , Ángel Rebollo-Román , José Manuel Quesada Gómez , Maria Angeles Galvez Moreno

IntroductionDenosumab (Dab) withdrawal is associated with a quick loss in bone mineral density (BMD) and a high risk of multiple vertebral fractures. It is still not stablished which strategy best prevents BMD loss after Dab discontinuation.AimCompare the use of bisphosphonates for one year after Dab withdrawal versus a tapering Dab regimen in terms of BMD and fracture occurrence.Method...

ea0073aep133 | Calcium and Bone | ECE2021

Serum and urinary calcium level in Latvian patients with sarcoidosis at the time of diagnosis – 2013–2018 data

Ruza Ieva , Plegermane Aiga

KeywordsSarcoidosis, serum, 24 h urine, calcium.IntroductionSarcoidosis is a systemic disease of unknown etiology that is defined by the formation of granulomas in different organ systems. Due to these pathologies, there may be an increase in serum and 24 h urine calcium that can have a clinical impact on the course of the disease.AimThe goal of this study was to ...

ea0073aep134 | Calcium and Bone | ECE2021

FGF23 secreting mesenchymal tumor of the foot: Localizing pitfalls

Sucaliuc Alina , Diana Anghel , Cristescu Ioan , Grigorie Daniel

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of chronic hypophosphatemia caused by the production of FGF23 in a typically small, benign, mesenchymal tumor. The diagnosis is often delayed and finding the tumor is sometimes challenging. We present a case of a 50 yrs old woman with TIO, referred to our clinic for progressive muscle weakness, diffuse bone pain and fractures, extensively investigated for 3 years. 2 years before admission she had a vertebroplas...

ea0073aep135 | Calcium and Bone | ECE2021

Osteoporosis treatment following osteoporotic fractures- data from a single medical center

Tell-Lebanon Osnat , Rosenblum Rachel Hava , Yaccobi Eyal , Ohana Nissim , Twito Orit , Rotman-Pikielny Pnina

BackgroundMost post-osteoporotic fracture patients do not receive osteoporosis treatment, although it reduces risks for additional fractures. This retrospective, observational study reviewed osteoporosis evaluation and treatment following typical osteoporotic fractures.MethodsWe identified patients with hip, vertebral, humerus or radius fractures, examined in Meir Medical Center, January-December 2017. Exclus...

ea0073aep136 | Calcium and Bone | ECE2021

Relationship between muscle function and trabecular bone score (TBS) in Type 2 diabetes mellitus

Ponce Maria Hayon , Martinez David Blanquez , Mª del Carmen Serrano Laguna , Maria Dolores Aviles Perez , Fontana Beatriz Garcia , Manuel Muñoz Torres

ContextThe incidence of Type 2 diabetes mellitus (T2DM) is increasing and muscle strength and function are reported to be decreased in patients with T2DM compared to healthy controls.However, the relation between bone and muscle remain unclear.ObjectiveOur aims was to examine bone health parameters [by Dual energy X-ray absorptiometry (DXA) and trabecular bone score (TBS)] and muscle strength (by hand grip) i...

ea0073aep137 | Calcium and Bone | ECE2021

Predictive factors for postoperative hypoparathyroidism after total thyroidectomy

Santos Tiago , André Carvalho , Cláudia Freitas , Raquel da Inez Correia , Costa Moreira da , Cardoso Maria Helena

IntroductionHypoparathyroidism (hypoPT) is one of the most complications after thyroid surgery, usually as transient hypocalcemia. Permanent hypoPT due to permanent parathyoid lesion, despite being less frequent, is associated to long term consequences for both objective and subjective well-being and should be prevented. Identifying predictive factors associated with post- thyroidectomy hypoPT is thereby crucial.Aim<p class="ab...

ea0073aep138 | Calcium and Bone | ECE2021

Continuous rhPTH(1–34) Treatment in Chronic Hypoparathyroidism

Saraiva Miguel , Chaves Ana Catarina , Guilherme Assunção , Saraiva Joana , Carvalho Rui

IntroductionHypoparathyroidism still remains the only hormone-deficiency related disorder whose standard treatment is not based on replacing the missing hormone. In the last few years, there has been growing evidence on the use of recombinant human PTH, mostly with subcutaneous injections of rhPTH(1–34). More recently, some clinicians have tried to administer teriparatide through a continuous delivery system using insulin pumps.<p class="abstext...

ea0073aep139 | Calcium and Bone | ECE2021

Metabolic disorders in patients with primary hyperparathyroidism

Bibik Ekaterina , Dobreva Ekaterina , Eremkina Anna , Aynetdinova Alina , Mokrysheva Natalya

BackgroundThe nonclassical complications of primary hyperparathyroidism (PHPT) can include metabolic syndrome associated with cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipidemia and other disorders are observed in patients with PHPT regardless of the severity of the disease. The aim of this study is to estimate metabolic parameters in patients with PHPT compared to...

ea0073aep140 | Calcium and Bone | ECE2021

Parathyroid crisis – a conspicuous case of hypercalcemia

Syeda Asma , coombs Nickolas , Mohammed Turab , Manne Madhuri

IntroductionParathyroid crisis (PC) is a very rare yet fatal clinical condition which mandates urgent intervention. We present a case of parathyroid crisis with severe symptomatic hypercalcemia and multi-organ involvement.Case descriptionA 63-year-old male presented with three days of generalized fatigue, abdominal pain and vomiting. Review of systems revealed constipation and symptoms suggestive of depressio...

ea0073aep141 | Calcium and Bone | ECE2021

Aggressive hypercalcaemia with recurrent giant parathyroid adenoma following three parathyroidectomies

Hussain Ayaz , Suri Ashwin , Ibrahim Hassan , Albor Christo , Hasnain Solat , Bashir Jawad

The incidence of recurrent primary hyperparathyroidism (PHPTH) (> 6 months from initial exploration) has been reported to be between 1–10%. Repeated neck explorations could be challenging for surgeons and ensuring normalised biochemistry is vital for peri-operative safety. Recurrent parathyroid adenomas can present with aggressive hypercalcaemia which can be challenging to control prior to surgery. We report a similar case below. A 72 year old lady had her first prese...

ea0073aep142 | Calcium and Bone | ECE2021

Height loss is almost 3 times more correlated with trabecular bone score than with bone mineral density

Peretianu Dan , Sarbu Adrian , Gavrila Catalin , Motoiu Serban , Stanciu Mihaela , Ranetti Aurelian , Paduraru Denis

AimTo show that height loss is more correlated with vetebral micoarchitecture than with Bone Mineral Density (BMD).Material and methodA. DEXA. Made with a GE-Lunar Prodigy Pro # 50 0074. Vertebral microarchitecture was investigated by Trabecular Bone Score (TBS). TBS software: TBS iNsight, version B. Patients. 784 patients, 737 (94%) women, 47 men. Only 38 under 50 years. Age average: 66.04 years. Wo...

ea0073aep143 | Calcium and Bone | ECE2021

Postsurgical hungry bone syndrome in unrecognized severe primary hyperparathyroidism: A case report

Ilijevska Cvetanka Volkanovska , Zivkovic Marija , Stevchevska Aleksandra , Otovikj Natasha Eftimovska , Hasan Taner , Mishevska Sasha Jovanovska

Parathyroidectomy for hyperparathyroidism can be complicated with development of Hungry Bone Syndrome (HBS), a constellation of profound hypocalcemia with hypomagnesemia and hypophosphatemia. The severity of this potential life-threatening condition is related to the extent of the parathyroid-mediated high-turnover bone disease. We present a case of a 59-year-old woman developing post-surgical HBS as a result of longstanding severe unrecognized primary hyperparathyroidism (PHP...

ea0073aep144 | Calcium and Bone | ECE2021

Quality of life changes in patients with primary hyperparathyroidism after parathyroidectomy: The usefulness of PHPQoL questionnaire in clinical practice

Gladkova Inna , Rusakov Vladimir , Chernikov Roman , Karelina Yulia , Nikitina Tatiana , Efremov Sergey , Ionova Tatiana

Primary hyperparathyroidism (PHPT) is a complex endoctinopathy that involves parathyroid glands which secreting too much parathyroid hormone and due to causes hypercalcemia effecting different organs and leading to significant quality of life (QoL) impairment. QoL assessment before and after surgery in patients with PHTP may be useful for comprehensive evaluation of the treatment effect, as well as for monitoring of the patient’ condition after surgery, including in real ...

ea0073aep145 | Calcium and Bone | ECE2021

Adjuvant endocrine therapy impact on bone health in premenopausal women with hormone receptor-positive breast cancer: Results of a case series

Lambrinoc Diana , Roxana Duşceac , Morea Alexandru , Cătălina Poiană

IntroductionAdjuvant endocrine therapy has an important role in the management of hormone receptor-positive (expressing oestrogen/progesterone receptors) early-stage breast cancer, reducing the risk of recurrence and improving associated mortality. The estradiol depletion produced by hormone therapy has detrimental effects on skeletal health, which can lead to low bone mineral density (BMD), altered bone microarchitecture and increased risk of fracture.<...

ea0073aep146 | Calcium and Bone | ECE2021

Parathyroid elastography―elastography evaluation algorithm

Cotoi Laura , Andreea Borlea , Cepeha Cristina Mihaela , Nicusor Pop , Daniela-Georgiana Amzar , Dana Stoian

IntroductionPrimary hyperparathyroidism is a common disorder of the parathyroid glands and the third most frequent endocrinopathy, especially among elderly women. Secondary hyperparathyroidism is a common complication of chronic kidney disease, associated with high cardiovascular morbidity and mortality. In both primary and secondary hyperparathyroidism, the need to correctly identify the parathyroid glands is mandatory for a better outcome. Elastography...

ea0073aep147 | Calcium and Bone | ECE2021

Topographic diagnosis of primary hyperparathyroidism

Bouzid Aicha , malha Azzouz , Meskine Djamila

IntroductionThe diagnosis of primary hyperparathyroidism (PHP) is essentially biological. Current imaging techniques (ultrasound and scintigraphy) make it possible to locate an adenoma in the majority of cases. The objective of this study is to clarify the place of imaging in the topographic diagnosis of hyperparathyroidism.Patients and methodsThis is a retrospective study including 40 patients with PHP who h...

ea0073aep148 | Calcium and Bone | ECE2021

Paraplegia: a serious consequence of treatment delay in hyperparathyroidism During the COVID-19 pandemic

Lopes Sara Campos , Carvalho Renata , Marques Sofia , Rocha Sofia , Viana Charlene , Marques Helena , José Pedro Pinto , Mário Reis , Cavadas Sofia , Pereira Ricardo S. , Monteiro Ana Margarida

BackgroundCurrently, serious complications of secondary hyperparathyroidism (sHPT) are rare due to early diagnosis and more effective treatments. These complications include osteitis fibrosa cystica, which is characterized by bone resorption and brown tumors. Depending on the location, they can cause pain or compressive symptoms.Case reportWe report a case of a 41-year-old black woman with a past medical hist...

ea0073aep149 | Calcium and Bone | ECE2021

Brown tumours resulting of secondary hyperparathyroidism in patients with chronic renal insufficiency

Masmoudi Mohamed , Guizani Rihab , Wadii Thabet , Nora Lamghari , Hasnaoui Mehdi , Khalifa Mighri

ObjectifBrown tumour is a rare focal bone lesion encountered in patients with uncontrolled hyperparathyroidism (HPT). This disease affects only 1.5% of patients with secondary HPT. This bone lesion can affect any part of the skeleton. The treatment is mainly medical based on reducing the rates of parathyroid hormone (PTH). Surgery is reserved for severe form of brown tumour or in case of uncontrolled level of PTH. The aim of our work is to illustrate the...

ea0073aep150 | Calcium and Bone | ECE2021

Symptomatic mastoidian brown tumor in a dialysed child

Anisia Miruna , Dumitru Teodora , Ungureanu Maria Christina , Preda Cristina , Magdalena Starcea , Leustean Letitia

Brown tumors (BT) consist of focal bone lesions, caused by increased osteoclastic activity and fibroblastic proliferation. They appear in chronic kidney disease (CKD) as a result of renal osteodystrophy with high bone turnover, due to secondary hyperparathyroidism. BT are composed of mononuclear stromal cells mixed with multinucleated giant cells and hemosiderin deposits, which give the characteristic brown colour. We present the case of a 13-year-old girl, with end-stage CKD ...

ea0073aep151 | Calcium and Bone | ECE2021

Phosphaturic mesenchymal tumour – diagnostic and therapeutic challenges

Zalewska Ewa , Monika Ploszaj-Neć , Bartosz Baścik , Szarmach Arkadiusz , Samson Lucjan , Piotr Łuczkiewicz , Katarzyna Goląbek-Dropiewska , Chmiel Joanna , Kardel-Reszkiewicz Ewelina , Kaniuka-Jakubowska Sonia , Sworczak Krzysztof

IntroductionTumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused mainly by a phosphaturic mesenchymal tumour (PMT) as a consequence of fibroblast growth factor 23 (FGF23) overproduction. The manifestation of TIO is mostly musculoskeletal. Locating the PMT is usually challenging and a successful surgical resection of the tumour leads to complete recovery.Case presentationA 42-year-old, Ca...

ea0073aep152 | Calcium and Bone | ECE2021

The relevance of the problem of osteoporosis for medical professionals working in the field of physical and rehabilitation medicine

Marchenkova Larisa

BackgroundThere is a high prevalence of osteoporosis (OP) among patients of the older age undergoing rehabilitation. Therefore, it is obvious that physicians working in the field of physical and rehabilitative medicine should be well oriented in this medical problem.Objectivesto study the relevance of the problem of osteoporosis (OP) for physicians working in the field of physical and rehabilitation medicine,...

ea0073aep153 | Calcium and Bone | ECE2021

Unexpected association of severe hypercalcemia and hypophosphatemia in a patient with chronic hypoparathyroidism: A case report

Vandi Giulia , Zavatta Guido , Repaci Andrea , Altieri Paola , Pagotto Uberto

Clinical vignetteA 65-year-old woman was hospitalized due to severe hypercalcemia (albumin-corrected calcium 16.9 mg/dl) associated with severe renal failure (creatinine 3.48 mg/ml), normal phosphate levels (3.9 mg/dl) and PTH < 5 pg/ml. Her past medical history included total thyroidectomy complicated by chronic hypoparathyroidism, for which she was followed by her primary care physician. One year before hospital admission, renal function was normal...

ea0073aep154 | Calcium and Bone | ECE2021

Male osteoporosis

Bouzid Aicha , Meskine Djamila , malha Azzouz

IntroductionOsteoporosis has generally been considered a female disease; this may explain why this pathology has focused less attention on men. While osteoporosis has been underestimated and poorly treated in female patients, the situation is even worse in male patients, despite the fact that up to one third of hip fractures are suffered by men.GoalTo assess the characteristics and risk factors associated wit...

ea0073aep155 | Calcium and Bone | ECE2021

8 cases of parathyroid cancer: One-center experience

Druzhkova Nataliya , Afanasieva Zinaida

IntroductionParathyroid carcinoma (PC) occurs in 0.5–5% of cases among patients with primary hyperparathyroidism (pHPT). The prognosis for patients with PC is variable and depends on the presence of local or distant metastases and the completeness of the initial surgery. About 50% of patients become recurrence of the disease and require palliative surgery and/or drug therapy aimed at correcting severe hypercalcemia.Objective</...