Diabetes, Obesity, Metabolism and Nutrition | 0073 | ECE2021 | European Congress of Endocrinology 2021

ea0073aep156 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The association of vitamin D with peripheral neuropathy among prediabetic individuals and the effect of vitamin D supplementation

Halawa Mohamed Reda , Ahmed Iman , Abouelezz Nahla Fawzy , Hendawy Laila Mohamed , Abdelaziz Naira Hany , Mohamed Nagwa Roshdy

BackgroundVitamin D deficiency seems to be more prevalent among diabetic patients with distal symmetrical polyneuropathy. Besides, those patients have a lower pain threshold; there is a shortage of data concerning pre-diabetic individuals with peripheral neuropathy (PN).AimFirst, to study the association of vitamin D deficiency with PN severity. Second, to determine the effect of vitamin D supplementation on ...

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ea0073aep157 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Lipid accumulation product can accurately rule out, but not rule in non-alcoholic fatty liver disease in type 1 diabetes

Mertens Jonathan , Dirinck Eveline , Vonghia Luisa , Francque Sven , Block Christophe De

IntroductionLipid accumulation product (LAP), an index based on waist circumference (WC) and serum triglyceride levels, is associated with the presence and severity of non-alcoholic fatty liver disease (NAFLD). However, its potential as a risk marker of NAFLD in subjects with type 1 diabetes (T1D) has not been studied yet.AimsThis study evaluated the ability of LAP to estimate the presence of NAFLD in adults ...

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ea0073aep158 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Assessment of serum adiponectin levels in patients with type 1 diabetes and chronic kidney disease

Sazonava Alena , Mokhort Tatsiana , Karlovich Natalia

AimsDiabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD). Renal impairment may affect not only glycemic control, but also metabolism of biologically active cytokines such as adiponectin. Taking into account multiple effects of adiponectin the purpose of the study was to assess its changes in patients with type 1 diabetes (T1D) and comorbid CKD.Materials and methodsWe recruited 129 pati...

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ea0073aep159 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Pharmacogenetics of metformin in polycystic ovary syndrome and type 2 diabetes mellitus

Strasser Moritz , Schweighofer Natascha , Obermayer Anna , Borzan Valentin , Haudum Christoph , Lerchbaum Elisabeth , Trummer Christian , Dimai Hans , Sourij Caren , Sourij Harald , Pieber Thomas , Obermayer-Pietsch Barbara

BackgroundMetformin is a widely used and effective agent in type 2 diabetes mellitus (T2DM) and polycystic ovary syndrome (PCOS). Yet, the mechanisms of action and the occurrence of side effects (e.g. abdominal bloating and pain), are still poorly understood. Since organic cation transporters (OCTs) are responsible for the hepatic and renal transport of metformin, we investigated a series of short nucleotide polymorphisms (SNPs) in the OCT genes in PCOS ...

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ea0073aep160 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Could we use SGLT2 inhibitors without serious concern in the elderly?

Ihintza Larrañaga , Vives Cristina Goena , Maria Magdalena Arteaga Ossa , Alvaro Jorge Rojo , Laura Mañas Alonso , Ovejero Laura Quintas , Begoña Maíz Alcorta , Rodrigo Ana Moreno , Nerea Andrés Imaz , Irene Larrañaga Gomez , Villar Ruth Agirrezabalaga , Abasolo Amaia Aspiazu , Suarez Teresa Arana , Dadebat Naroa Rico , Amaia Cristina Armentia Del Pozo , Irizar Sara Diez , Tijero Naroa Gomez , Jose Francisco Egido Arroyo

BackgroundTherapeutic experience with SGLT2i is limited in the elderly. Its initiation is not recommended in patients over 85 years based on volume depletion risk. The aim of this study is to analyze clinical efficacy and safety of SGLT2i in elder T2DM patients.MethodsThis observational retrospective study included 544 T2DM subjects who initiated SGLT2i as add-on treatment between February 20182019 and ...

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ea0073aep161 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

An analysis of flash glucose monitoring (FGM) data on insulin-treated patients with diabetes: Effects of COVID-19 lockdown

Ashraf Tanveer , Helal Radwa , Majeed Maria , Lessan Nader

IntroductionFollowing the WHO declaration of COVID-19 as a pandemic and as many countries around the world, the United Arab Emirates government introduced gradual measures to stop the spread of the virus placing the country in a state of almost complete-lockdown. We report the impact of these restrictions on glucose control in patients with type 1 diabetes (T1D) and type 2 diabetes (T2D) on insulin therapy.Methods<p class="abst...

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ea0073aep162 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effects of long-term testosterone therapy on anthropometric parameters in men with functional hypogonadism and obesity: 12-year observational data from a controlled registry study in a urological setting

Saad Farid , Haider Karim Sultan , Haider Ahmad

BackgroundWhile almost all studies consistently show reduction of waist circumference as a result of testosterone therapy (TTh), effects on body weight are inconsistent and may depend on treatment duration, route of administration, and adherence.Material and methodsAfter excluding men with primary hypogonadism, 476 men with functional, symptomatic hypogonadism were obese. 281 men received testosterone undecan...

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ea0073aep163 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Semaglutide reduces fat accumulation in the tongue of obese women with polycystic ovary syndrome: A randomized, placebo-controlled prospective study

Jensterle Mojca , Ferjan Simona , Vovk Andrej , Battelino Tadej , Rizzo Manfredi , Janez Andrej

ObjectiveFat depot in the tongue that represents 2530% of the total tongue mass is largely unaddressed. It correlates with body mass index. The response to weight reduction induced by different anti-obesity modalities may vary between body fat compartments. Semaglutide, a long acting GLP-1 receptor agonist (GLP-1 RA), has the potential to reduce body mass with at least 2 to 3 times greater weight reduction than other studied GLP-1 RAs. This is the ...

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ea0073aep164 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The short-term effect of surgical and pharmacological intervention in obesity caused by MC4R deficiency: A single centre experience

Radha Saradalekshmi Koramannil , Fojas Esphie Grace , Ali Tomader , Suliman Sara GI , Lessan Nader

IntroductionMelanocortin-4-receptor (MC4R) deficiency is the commonest of the rare monogenic forms of obesity. Bariatric surgery (BS) is the most efficacious treatment modality in the more common polygenic obesity. Effect of surgical and drug treatment in obesity due to MC4R deficiency is not well-established.AimWe aimed to explore the effects of BS and drug treatment among the confirmed cases of ...

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ea0073aep165 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Circulating microRNAs as predictive tool of the effectiveness of lifestyle intervention for weight loss

Clemente-Postigo Mercedes , Coin-Araguez Leticia , Jose Carlos Fernández-García , Alcaide-Torres Juan A , Bekay Rajaa El , Bernal-Lopez Maria Rosa , Macias-Gonzalez Manuel , Tinahones Francisco J

Background and aimsLifestyle modifications based on diet and exercise are common strategies for the treatment and prevention of obesity and related comorbidities. However, not all patients respond equally to similar weight loss intervention which compromise patient adherence. Strategies for predicting the individual response are required for improving intervention efficiency by personalized recommendations. microRNAs (miRNAs), small RNA particles which r...

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ea0073aep166 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The ecology of the microbiome in children with obesity is associated to insulin resistance anddiet composition

Ricotti Roberta , Archero Francesca , Landoni Valentina , Mancioppi Valentina , Caputo Marina , Bellone Simonetta , Solito Arianna , Antoniotti Valentina , Gamalero Elisa , Massa Nadia , Mignone Flavio , Cavaletto Maria , Agosti Emanuela , Bona Elisa , Prodam Flavia

IntroductionIn the pediatric population, the progression of obesity-related diseases can be delayed or prevented through lifestyle changes, including the promotion of a Mediterranean-like dietary (MD) pattern.ObjectiveWe aimed to evaluate the gut microbiome ecology in relation to dietary and clinical parameters in the pediatric subjects with obesity recruited at baseline in a protocol on an educational traini...

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ea0073aep167 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Amniotic membrane treatment of an oxidative stress murine chronic diabetic wound model

Panayi Adriana , Wu Mengfan , Liu Qinxin , Karvar Mehran , Aoki Shimpo , Endo Yori , Ma Chenhao , Hamaguchi Ryoko , Orgill Dennis

BackgroundTo date, available animal models have failed to replicate the complex pathophysiology of chronic diabetic wounds. In a recent study we administered a regimen of antioxidant enzyme inhibitors (AIE) to develop a reliable and effective murine model. Here we use this model to test the efficacy of an amniotic membrane (AM) scaffold.Methods30 db/db mice received a pre-established AIE regimen and a 1 &#215...

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ea0073aep168 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Use of the thrombolysis in myocardial infarction risk score for heart failure in diabetes in a type 2 diabetes mellitus outpatient population

Ramalho Diogo , Correia Sara , Almeida Lucia , Alves Helena , Melo Gustavo , Maria João Oliveira

BackgroundType 2 Diabetes Mellitus (T2DM) and Heart Failure (HF) are two directly related diseases associated with considerable morbimortality. The prevalence of HF in T2DM populations is up to 20%, 4 times higher than the general population. Additionally, health-related quality of life, hospitalizations for HF (HHF) and mortality risk are more common when both are present. Hence, HHF risk assessment in T2DM patients may lead to prompt preventive interve...

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ea0073aep169 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Glycemic control and complication rate through pregnancy and thirteen-years post-partum in women with microalbuminuria (type 1 diabetes T1DM)

Asatiani Natalia , Kurashvili Ramaz , Inashvili Ekaterine , Shelestova Elena , Kopaleishvili Ana

The aim of the present work was to assess the degree of glycemic control and complications rate through pregnancy and thirteen-years post-partum in women with microalbuminuria (T1DM).Materials and methodsIn total 191 patients with T1DM were enrolled in the study. Based on albuminuria levels in the 1st trimester women were separated into 2 groups (Gr.). Gr.1 116 women with normoalbuminuria, Gr.2 75 women wit...

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ea0073aep170 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Impact of social isolation and quarantine on the course of diabetes mellitus and its complications during Covid 19 pandemic in Adjara Region Country of Georgia

Jashi Liana , Dundua Ketevan , Kvanchakhadze Rusudan , Nizharadze Nino

BackgroundSARS-CoV-2 infection produces greater morbidity and mortality in people with cardiovascular disease, diabetes, and obesity. Quarantine and social distancing are necessary measures to prevent the virus from spreading but also lead to elevated levels of loneliness and social isolation. The aim of the study was to research impact of Social isolation and quarantine on compensation of diabetes and on progression of its complications.<p class="ab...

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ea0073aep171 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Risk factors of cardiovascular autonomic neuropathy in patients with prediabetes and coronary artery disease

Stepura Olena , Zherdova Nadiia , Georgy Manko vs ky , Mankovsky Borys

BackgroundCardiovascular autonomic neuropathy (CAN) is a chronic complication associated with high risk of cardiovascular morbidity and mortality either in patients with diabetes mellitus and prediabetes. However, risk factors of CAN in patients with prediabetes and coronary artery disease (CAD) was not fully investigated.AimsThe aim of this study was to investigate risk factors of CAN in patients with predia...

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ea0073aep172 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

NaKATPase activity regulated by glycemia level in patients with DM

Shamansurova Zulaykho , Saatov Talat , Tsoy Arina

IntroductionNaKATPase is membrane bound enzyme, necessary for maintenance of the cell potential and volume, ion flow, neuronal signal transduction. Previous studies showed decreasing of its activity in patients with diabetes mellitus (DM). Mechanisms regulated enzymes activity in DM is not clear yet. We proposed that glycemia is a main regulator of NaKATPase activity in erythrocytes at the DM.Material and methods<p class="abste...

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ea0073aep173 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Hirata’s disease (Insulin autoimmune syndrome) in an Egyptian female patient: A case report

Halawany Salah El

IntroductionInsulin autoimmune syndrome (IAS), is rare cause of hyper-insulinemic hypoglycemia due to production of autoantibodies against the endogenous insulin in persons not formerly received insulin with no evidence of pancreatic lesions. Most described cases were in Asian peoples and this is the first case reported from Egypt.Case reportA 64-year-old Egyptian female presented with repeated postprandial h...

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ea0073aep174 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Severe postprandial hypoglycemia as a possible sequel of COVID-19

Ricardo de León Durango , Alba Hernández Lázaro , Paula Maria Fernandez-Trujillo-Comenge , Kuzior Agnieszka , Nivelo-Rivadeneira Manuel Esteban , Santana-Suarez Ana Delia , Acosta-Calero Carmen , Arnas-Leon Claudia , Gonzalez-Diaz Paula , Martinez-Martin Francisco Javier

IntroductionCOVID-19 is an evolving disease and its clinical picture is constantly being updated. Severe hypoglycemia has not been usually recognized as a COVID-19 symptom (except when caused by hydroxychloroquine toxicity) but in our patient it has been apparently triggered by the disease.MethodsReview of the patients records and the relevant literature.Clinical case<p class=...

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ea0073aep175 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Increased anxiety, depression and body dysmorphia in women with polycystic ovary syndrome: Results from blue morpho survey

Sheikh Jameela , Hebbar Meghnaa , Zia Nawal , Wicks Saskia , Jayaprakash Sindoora , Narendran Alisha , Khalil Halimah , Melson Eka , Busby Maureen , Tahrani Abd , Hillman Sarah , Chapman Rachel , Gleeson Helena , Singh Ruchira , Robinson Lynne , Manolopoulos Konstantinos , Gillett Caroline DT , Thangaratinam Shakila , Arlt Wiebke , Kempegowda Punith

BackgroundPolycystic Ovary Syndrome (PCOS) is a common reproductive, endocrine and metabolic disorder. The UK National Institute of Health and Care Excellence (NICE) recommends evaluating emotional wellbeing in women with PCOS. Therefore, we conducted a health service evaluation to assess emotional wellbeing.MethodsWe invited women with PCOS via social media to complete an online survey in September 2020, sup...

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ea0073aep176 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

COVID-19 and diabetes: Impact on emergency department demand by diabetic patients. experience from a portuguese center

Maria João Ferreira , Pedro Jorge , José Luis Castedo , Pereira Fernando , Carvalho Davide , Tiago Guimarães

IntroductionCOVID-19 is an emerging disease caused by the new coronavirus (SARS-CoV-2) that has overburdened healthcare worldwide. In Portugal, schedule appointments were cancelled, postponed or changed to tele-consultation. The objective of the study is to assess the impact of the pandemic on the use of Emergency Department (ED) by diabetic patients.Material and methodsRetrospective monocentric study of the ...

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ea0073aep177 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

ER stress and toxic soluble misfolded proteins are present in diabetes and diabetic ketoacidosis in a sex dependent-manner

Furtado Janara , Bearss Nicole R. , Mccarthy Cameron G , Nazzal Munier , Hoffman William B. , Wenceslau Camilla F.

IntroductionDiabetes, a metabolic disease, is responsible for 1.6 million deaths each year. Type 2 diabetes (T2D) is the most common type (90%) that usually occurs in adults. Type 1 diabetes (T1D) an autoimmune disorder, affects more children and adolescents. Diabetic Ketoacidosis (DKA) is the most common acute cause of morbidity and mortality in youth with T1D. Soluble protein oligomers (SPOs), are a class of misfolded toxic proteins released during end...

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ea0073aep178 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

High prevalence of 1^st trimester gestational diabetes mellitus in polish women is accompanied by insulin resistance similar to pcos cohort

Lewandowski Krysztof , Gluchowska Monika , Garnysz Karolina , Horzelski Wojciech , Lewinski Andrzej

Back groundBoth pregnancy and polycystic ovary syndrome (PCOS) constitute insulin-resistant states, while gestational diabetes (GDM) is associated with adverse pregnancy outcomes. Though screening for GDM is typically performed later in pregnancy, some women demonstrate significant insulin resistance (IR) and develop GDM even in 1st trimester. We have endeavoured to compare surrogate IR indices in 1st trimester pregnant women and in...

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ea0073aep179 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Mother’s education with type 1 diabetes and the risk of some neonatal outcomes

Prylutskaya Veranika , Skryplionak Tatsiana , Solntsava Anzhalika , Shyshko Yuliya

AimTo evaluate some neonatal outcomes, depending on the level of education of the mother with type 1 diabetes (T1DM).Materials and methodsA retrospective single-center study was carried out among 430 children from mothers with T1DM, who were born in 2015-2020 years. Taking into account the level of education of mothers, newborns were divided into 3 observation groups. The first group (Gr1) consisted of 70 chi...

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ea0073aep180 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Vitamin B12 status and maternal-fetal outcomes among women with gestational diabetes

Gutu Olga , Natércia Candeias , António Afonso , Silva-Nunes Jose

IntroductionVitamin B12 (vB12) deficiency has been associated with a plethora of hematologic, neurologic and metabolic abnormalities. In pregnant women, several studies have demonstrated an association with a greater maternal body mass index (BMI), maternal and offspring insulin resistance, gestational diabetes mellitus (GDM) and even later type 2 diabetes.Aim of the studyEvaluation of maternal and fetal outc...

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ea0073aep181 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Glucagon levels in women with Alzheimer’s disease

Vankova Marketa , Vcelak Josef , Vejrazkova Daniela , Bendlova Bela

Alzheimers disease (AD) is a neurodegenerative disease that manifests itself in the gradual loss of cognitive and behavioral functions. In humans, glucagon is processed in pancreatic alpha cells located next to insulin-secreting beta cells, suggesting a local interaction. Glucagon is also produced in the intestinal L-cells and in small amounts in the hypothalamus. The main function of glucagon is to counteract the effects of insulin and thus maintain balanced blood gluco...

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ea0073aep182 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Glycemic control in patients with different types of diabetes mellitus in Ukraine

Globa Eugenia , Nataliya Zelinska

IntroductionThe aim of this study, which was conducted for the first time in Ukraine, was to analyze a glycemic control in patients with different types of diabetes mellitus (DM), including neonatal (ND) and maturity onset diabetes of the young (MODY) and changing their treatment after the results of genetic testing.Materials and methodsThe Ukrainian Pediatric Diabetes Register was established in 2002 and inc...

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ea0073aep183 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Increase in PUFA and in protein intake leads to reduction of liver fat independently of weight loss in 12 months: the NutriAct trial

Pletsch-Borba Laura , Wernicke Charlotte , Apostoloupoulou Konstantina , Spira Dominik , Pohrt Anne , Hornemann Silke , Gerbracht Christiana , Pfeiffer Andreas , Spranger Joachim , Mai Knut

BackgroundLong-term effects of an increase in unsaturated fatty acids and protein on changes in intrahepatocellular lipids (IHL) are still unclear. We aimed to explore the impact of changes in individual macronutrients on IHL changes within the NutriAct intervention trial over 12 months in middle-aged and elderly subjects (5080 yrs) at risk for age-related diseases.DesignIn the NutriAct randomized contr...

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ea0073aep184 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Diabetes mellitus is associated with a higher relative risk for Parkinson’s disease in women than in men

Deischinger Carola , Dervic Elma , Kaleta Michaela , Klimek Peter , Kautzky-Willer Alexandra

IntroductionIn general, the risk to develop Parkinsons disease (PD) is higher in men compared to women. Besides male sex and genetics, research suggests diabetes mellitus (DM) is a risk factor for PD as well. In this population-level study, we aimed at investigating the sex-specific impact of DM on the risk of developing PD.Research design and methodsMedical claims data were analyzed in a cross-sectiona...

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ea0073aep185 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Anemia in diabetes and pre-diabetes with normal kidney function: Prevalence and long- term association with morbidity and mortality

Erez Daniel , Shaefler Coral , Roitman Eytan , Levy Sigal , Ellis Martin , Dovrish Zamir , Twito Orit

BackgroundAlthough anemia was previously described as a complication of diabetes mellitus (DM), its prevalence and prognostic meaning in patients with DM and pre-DM with normal kidney function was not thoroughly investigated.MethodsA retrospective analysis of patients with DM and pre-DM referred to the endocrine institute in Meir medical center during 2015. Patients with estimated glomerular filtration ...

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ea0073aep186 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Cardiorenal outcomes and T2DM control in new users of SGLT2 inhibitors in combination therapy

Ihintza Larrañaga , Vives Cristina Goena , Maria Magdalena Arteaga Ossa , Jose Francisco Egido Arroyo , Begoña Maíz Alcorta , Laura Mañas Alonso , Ovejero Laura Quintas , Rodrigo Ana Moreno , Nerea Andrés Imaz , Amaia Cristina Armentia Del Pozo , Abasolo Amaia Aspiazu , Villar Ruth Agirrezabalaga , Irene Larrañaga Gomez , Irizar Sara Diez , Suarez Teresa Arana , Dadebat Naroa Rico , Josu Pérez Yéboles

Introduction and objectivesSGT2i have changed the paradigm of T2DM management. Last guidelines insist on the importance of using newer glucose-lowering drugs with a demonstrated reduction in cardiovascular events (CVE). The aim of this study is twofold: to describe CVE, heart failure (HF) and renal function evolution; and to assess its efficacy in non-selected patients with T2DM initiating SGLT2iMaterial and methods<p class="ab...

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ea0073aep187 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Free T4 is associated with exenatide-related weight loss in patients with type 2 diabetes mellitus

Ömercan Topaloğlu , Didem Yıldız Toksöz

IntroductionExenatide may provide weight loss in type 2 diabetes mellitus (T2D) via agonistic effect on GLP1 receptor. There is no study showing associations between free T4(fT4) and exenatide-related weight loss in T2D. We aimed to reveal the association between fT4 and exenatide-related weight loss, and change in thyroid functions with exenatide in euthyroid adult patients with T2D and obesity.Materials and Methods<p class="a...

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ea0073aep188 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Feasibility study of IoT telemonitoring for elderly patients with type 2 diabetes mellitus: Results of the Greek pilot of the ACTIVAGE multicenter randomised control trial

Dafoulas George , Karaberi Christina , Segkouli Sofia , Dimakopoulos George , Votis Konstantinos , Tzovaras Dimitrios , Bargiota Alexandra

IntroductionThe aim of the present feasibility study was to examine the impact of an Internet of Things (IoT) telemonitoring program, for elderly patients with type 2 diabetes mellitus (DMT2) on glycemic control.MethodsIn this feasibility, prospective, randomized, single-blinded, multicenter study elderly patients with DMT2 capable to use the IoT telemonitoring device, with an HbA1c > 7.5 were followed-up...

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ea0073aep189 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Type 1 Diabetes and physical activity – which are the barriers to its practice and what is therole of therapeutic education?

Juliana Marques-Sá , Lopes Sara Campos , Santos Maria Joana

*These authors contributed equally to this work.BackgroundRegular physical activity has a crucial role in the control of Type 1 Diabetes (T1D). Insecurity in the management of insulin therapy and fear for dysglycemia are barriers to the practice of exercise in T1D.AimTo identify barriers to regular physical activity in adult patients with T1D; to evaluate the impact of two ed...

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ea0073aep190 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The effect of increasing soluble diatery fibre content of meals on postprandial glycaemic and c-peptide response

Idris Muhammad Aliyu , Sabir Anas Ahmad , Ohwovoriole Augustine Efedaye

BackgroundMedical nutrition therapy is often the initial step in the management of Prediabetes and diabetes mellitus. Postprandial glycaemia contributes significantly to the glycaemic control of patients with diabetes mellitus. The beneficial effects of soluble dietary fibre in reducing postprandial glycaemia have been established. The 2017 global burden of disease (GBD) report shows that 97.000 deaths result from low fibre intake. Despite the this, the ...

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ea0073aep191 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Erythrocytosis in a patient on sodium glucose cotransporter-2 inhibitor

Byrne Shane , Nor Mohammad Aiman , Crotty Gerard , Kyithar Ma Pyeh

BackgroundSodium glucose cotransporter-2 (SGLT-2) inhibitors have proven valuable in the management of type 2 diabetes. These agents are particularly effective in reducing hospitalisations with heart failure and cardiovascular mortality. Adverse effects are primarily centred on urogenital infections and hypovolaemia. Here, we report the case of a patient who developed asymptomatic erythrocytosis while taking empagliflozin.Case repo...

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ea0073aep192 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Investigation of 5 alpha reductase-1 and aromatase enzyme levels, gene expressions and kisspeptin and nesfatin-1 levels in male patients with metabolic syndrome and hypogonadism

Halil Güner , Yaylali Guzin , Mücahit Seçme , İbrahim Açıkbaş , Hande Şenol

Metabolic syndrome-associated hypogonadism is an important problem in men and is thought to occur by complex pathogenetic pathways. 26 men with metabolic syndrome-related hypogonadism, 26 men with metabolic syndrome with normal testosterone levels, and 26 healthy men were included in this study to examine the factors that may affect these pathogenetic pathways. Plasma nesfatin-1, kisspeptin, 5 alpha reductase-1 and aromatase levels and plasma 5 alpha reductase-1 and aromatase ...

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ea0073aep193 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Comparative analysis of the methods for differential diagnosis of non-diabetic hypoglycemia (NDH): Beta-hydroxybutyrate and glucagon test

Yukina Marina , Nuralieva Nurana , Troshina Ekaterina

Introductionsome authors propose to conduct consistently two additional tests for differential diagnosis (DD) of NDH with the main purpose to confirm or exclude the autonomous hyperinsulinemia (AH; insulinoma): determination the capillary beta-hydroxybutyrate (BHB) during prolonged fasting test (FT), and glucagon test (GT) at the moment of hypoglycemia. GT is more labor-intensive, high-cost and lead to potential complications. Therefore, we assumed that ...

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ea0073aep194 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Hedonic rating of sucrose is sub-regionally associated with striatal dopamine transporter in humans

Pak Kyoungjune , Seo Seongho , Lee Myung Jun , Kim Keunyoung , Suh Sunghwan , Lee Jeehyun , Kim Injoo

Eating behavior is determined by both homeostatic and hedonic values. We investigated the association of hedonic value with striatal dopamine transporter (DAT) availability sub-regionally. An intravenous bolus injection of 18F-FP-CIT was administered after the infusion of glucose or placebo, and the emission data were acquired over 90 mins. DAT availability, binding potential (BPND), were measured via the simplified reference tissue method. Subje...

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ea0073aep195 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

glycaemic control in patients with Gestational Diabetes requiring betamethasone – a quality improvement project with intravenous insulin infusion protocol

Malik Ihtisham

Administration of antenatal steroids for foetal lung maturity is considered for all women at risk for preterm birth before 37 weeks. Administration of two doses of betamethasone 12 mg intramuscularly, 24 hours apart may result in a deterioration of glycaemic control for 23 days in patients with gestational diabetes (GDM), thereby potentially affecting foetal wellbeing. Current practice was noted to be inconsistent, and a protocol was drawn up for variable rate insulin in...

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ea0073aep196 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Combined vildagliptin + metformin therapy can increase telomerase activity in patients with type 2 diabetes

Dudinskaya Ekaterina , Matchekhina Lubov , Strazhesko Irina , Tkacheva Olga

IntroductionMetformin and vildagliptin are the medications amongst first-line treatment options in type 2 diabetes patients. Few recent studies have explained positive pleotropic effects of metformin therapy by telomerase activation and telomeres length in leukocytes preservation. Knowing the primary role of insulin-signalling pathway in insulin resistance development and physiology of ageing, it is possible to suggest, that one of the protective mechani...

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ea0073aep197 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Maternally inherited diabetes and deafness, associated with a novel mitochondrial mutation, complicated by sever hypertriglyceridemia: Case report

Rekik Nabila , Gherissi Wiem , salah Dhoha Ben , Salah Ameni , Mnif Mona , Mnif Fatma , Hadjkacem Faten , Charfi Nedia , Elleuch Mona , Abid Mohamed

IntroductionMitochondrial diseases are a clinically heterogeneous group of disorders that arise as a result of dysfunction of the mitochondrial respiratory chain.it is genetically heterogeneous diseases characterized by multisystem involvement. Thus, its clinical description is incomplete. The aim of this case report is to highlight the association between mitochondrial diabetes and severe hypertriglyceridemia. In this study, we describe the case of a 22...

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ea0073aep198 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Elderly patients with Type 2 Diabetes and Covid-19: the impact of glycemic control on the outcomes

Cátia Andreia Araújo , Bárbara Filipa Araújo , Melo Miguel , Baptista Carla , Paiva Sandra , Paiva Isabel

IntroductionDiabetes mellitus (DM) is one of the major comorbidities in patients with Coronavirus disease (COVID-19) leading to poorer outcomes. Previous evidence showed that poorly-controlled hyperglycemia increases the severity and mortality of COVID-19. Nevertheless, there is limited data on the role of in-hospital glucose control on the outcomes of elderly patients with type 2 diabetes mellitus (T2DM).Objective<p class="abs...

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ea0073aep199 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Diabetes mellitus and COVID-19 – The bidirectional impact

Inês Manique , Alexandra Abegão Matias , Rego Teresa , Sabino Teresa , Bouca Bruno , Ana Cláudia Martins , Mihon Claudia , António Panarra , José Silva-Nunes

IntroductionSARS-CoV2 infection can worsen glycemic control regardless of history of Diabetes mellitus (DM) and may precipitate new-onset diabetes (NOD). DM is also a risk factor for a greater severity of COVID-19. At-admission hyperglycemia (AH) is a known predictor of critical illness in other diseases.AimsAssess the impact of AH, regardless of the presence of DM, on the severity of COVID-19 inpatients....

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ea0073aep200 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

IL-18 in the Glucose Continuum

Nedeva Iveta , Gateva Antoaneta , Assyov Yavor , Karamfilova Vera , Velikova Tsvetelina , Yamanishi Kyosuke , Kamenov Zdravko , Okamura Haruki

BackgroundBoth obesity and diabetes are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. The aim of the present study was to investigate the circulating levels of IL-18 in different stages of glucose dysregulation from obesity through prediabetes to newly diagnosed diabetesMethodsIL-18 levels were determined using a commercia...

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ea0073aep201 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Liraglutide for weight management in syndromic obesity: effects in overgrowth adult Beckwith–Wiedemann syndrome

Caputo Marina , Daffara Tommaso , Bellone Simonetta , Mancioppi Valentina , Marzullo Paolo , Aimaretti Gianluca , Prodam Flavia

ContextGenetic obesity, including syndromic and non-syndromic forms, represent a minority of cases but gene dysregulations make their management particularly difficult. Among them, BeckwithWiedemann syndrome (BWS) is a multisystem human genomic imprinting disorder characterized by overgrowth, macroglossia, abdominal wall defects, hemi hyperplasia, enlarged abdominal organs, and an increased risk of embryonal tumours. The syndrome is caused by genet...

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ea0073aep202 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Role of circulating cell-free deoxyribonucleic acid in the management of obese patients with breast cancer: Diagnostic impact, prognosis and relationship with obesity

Chiboub Marwa , Mnif Fatma , Benothman Wafa , Kais Chaaben , Mohamed Abid , Boutheina Cherif

IntroductionCirculating cell-free deoxyribonucleic acid (cfDNA) is a topical subject that has proven its place in oncology. However, its regular use is always compromised by the relatively high cost of the technique. The objective of our study is to determine the usefulness of cfDNA in the management of obese patients with breast cancer as well as its prognostic impact.MethodsUsing real-time multiplex polymer...

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ea0073aep203 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Is there an association between sex steroids and biopsy-proven non-alcoholic fatty liver disease in obese men? A cross-sectional analysis of 134 men

Herdt Carlien De , Block Christophe De , Kristof Van Dessel , An Verrijken , Francque Sven , Dirinck Eveline

Background and aimsLow levels of testosterone and non-alcoholic fatty liver disease (NAFLD) in obese men are both linked to the metabolic syndrome, but the independent association between testosterone and NAFLD needs to be elucidated. In this cross-sectional analysis the association between total testosterone (total T) and calculated free testosterone (cFT) on the one hand and NAFLD, non-alcoholic steatohepatitis (NASH) and fibrosis on the other hand was...

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ea0073aep204 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The role of vitamin D deficiency in the development of latent autoimmune diabetes in adults

Tsaryk Iryna , Pashkovska Nataliia

IntroductionVitamin D deficiency is recognized as a global problem worldwide. Today, there is information about the relationship between vitamin D levels and the pathogenetic links in the development of classic forms of diabetes mellitus (DM). In particular, vitamin D deficiency has been shown to cause insulin deficiency, progression of insulin resistance, and β-cell dysfunction. There is growing evidence that vitamin D deficiency may be a risk fact...

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ea0073aep205 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Prevalence of erectile dysfunction among the subjects with type 2 diabetes mellitus in the indian state of punjab

Talwar Vipan , Talwar Gourav

BackgroundErectile Dysfunction (ED) is one of the most common sexual dysfunction occurring in men with Type 2 diabetes mellitus (T2DM) but its evaluation is often neglected in routine clinical practice. There is hardly any data on the prevalence of ED among the males with Type 2 diabetes mellitus in the Indian state of Punjab.AimsThis cross sectional study was conducted to find out the frequency and risk fact...

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ea0073aep206 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The effect of renin-angiotensin-aldosterone system inhibitors on binary and continuous renal outcomes in subgroups of patients with diabetes: an extensive meta-analysis

Alsalemi Noor , Elftouh Naoual , Louis Maudeline , Sadowski Cheryl , Jean-Philippe Lafrance

IntroductionDiabetic nephropathy is the leading cause of end-stage-kidney disease (ESKD). Clinical practice guidelines recommend prescribing reninangiotensin aldosterone system inhibitors (RAASi) to prevent diabetic nephropathy at any stage. We conducted this extensive meta-analysis to compare the effects of RAASi with placebo and other antihypertensives in adults with diabetes on binary and continuous renal outcomes to provide a comprehensive revi...

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ea0073aep207 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Correction of oxidative stress in experimental diabetes mellitus by means of natural antioxidants

Saatov Talat , Mustafakulov Mukhammadjon , Irgasheva Sanobarkhon , Ibragimov Zafar , Ibragimova Elvira , Ishanhodjaev Tokhir , Zainutdinov Bakhodyr , Samarkhodjaeva Nigora , Abdullakhodjaeva Nodira

Associated with the increased generation of free radicals and reduced activity of antioxidant system, oxidative stress is a pathogenetic mechanism underlying the onset of diabetic complications. Antioxidants are known to facilitate normalization of lipid peroxidation, composition, structures and functions of biological membranes. Antioxidants are universal membrane-trophic agents protecting against damaging factors. Plant antioxidants play a significant role in treatment of di...

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ea0073aep208 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Clinical and biochemical differences in diabetic ketoacidosis in people with type 1 and type 2 diabetes mellitus

Ooi Emma , Rengarajan Lakshmi , Melson Eka , Thomas Lucretia , Johnson Agnes , Zhou Dengyi , Wallett Lucy , Ghosh Sandip , Narendran Parth , Kempegowda Punith

IntroductionOnce thought to typify type 1 diabetes mellitus (T1DM), diabetic ketoacidosis (DKA) in people with type 2 diabetes mellitus (T2DM) is also now increasingly recognized. We explored the clinical and biochemical differences in DKA in the two types of diabetes.MethodsThis retrospective cohort study included all the DKA episodes from April 2014 to September 2020 at a large tertiary care centre in West ...

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ea0073aep209 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Clinical and biochemical assessment of erectile dysfunction in men with type 1 diabetes

Hakiri Ghofrane , Ounaissa Kamilia , Mahrez Achwek , Dridi Manel , Sebai Imen , Abdessalam Haifa , Brahim Asma Ben , Yahiaoui Rym , Amrouche Chiraz

BackgroundErectile Dysfunction (ED) is a common complication of diabetes, but also one of the most underdiagnosed. ED is considered a vascular impairment that shares many risk factors with cardiovascular disease (CVD) and could be an early marker of systemic endothelial dysfunction. The aim of our study is to assess the prevalence and risk factors for ED by using the International Index of Erectile Function- 5 (IIEF-5) in type 1 diabetic men undergoing a...

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ea0073aep210 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Diabetic bullosis: about 2 cases

Chabchoub Imen , Elleuch Mouna , Salah Dhoha Ben , Safi Wajdi , Charfi Nadia , Mnif Mouna , Faten Hadj Kacem , Mejdoub Nabila , Mohamed Abid

IntroductionDermatological manifestations associated with diabetes affect approximately 30% of patients. Diabetic Bullosis is a rare complication of diabetes. It is a rare bullous dermatosis charecterised by the occurrence of bubbles on healthy skin with variable levels of cleavage.ObjectiveWe propose to study the epidemiological, clinical and evolutionary characteristics of Diabetic Bullosis in diabetic pati...

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ea0073aep211 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Selective sodium-glucose cotransporter inhibitors 2 (isglt2) in patients with high risk of amputation

Mª del Carmen Serrano Laguna , Verónica Ávila Rubio , Sara León Utrero , Pablo José López-Ibarra Lozano

IntroductionThe use of iSGLT2 remains controversial in diabetic patients with peripheral arterial disease.ObjectivesAssess metabolic effect and risk of amputations of iSGLT2 in diabetic patients treated in the Multidisciplinary Unit of Diabetic Foot (MUDF) comparatively with a control group.Design and methodsRetrospective observational study in which the patients ...

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ea0073aep212 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Influence of diabetes in heart failure with preserved ejection fraction

Borges-Canha Marta , Francisco Vasques-Nóvoa , Saraiva Francisca , Leite Ana Rita , Oliveira Ana Cristina , Neves Joao Sergio , Hafe Madalena von , Vale Catarina , Carvalho Davide , Adelino F. Leite-Moreira

IntroductionHeart Failure with Preserved Ejection Fraction (HFpEF) denotes a growing challenge due to the population aging and the rising prevalence of cardiovascular risk factors.AimWe aimed to evaluate the influence of the diagnosis of diabetes mellitus (DM) on the signs and symptoms, comorbidities and echocardiographic and vascular evaluation of patients with HFpEF in a stable phase....

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ea0073aep213 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Analysis of lipid profile in a sample of patients with type 1 diabetes (T1D)

Fuentes-Damas Miguel , Garcia Carmen Hernandez , Jose Ignacio Martinez Montoro , Valero Andrea Fernandez , Francisco Tinahones Madueño

IntroductionDyslipidemia is a major cardiovascular risk factor, being its detection and control essential due to risk of serious complications. Numerous trials have demonstrated its relationship with T2D, but it has not been so well studied in T1D.ObjectiveTo obtain information about relationship between dyslipidemia and T1D and analyze its prevalence and control in a sample of patients.<p class="abstext"...

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ea0073aep214 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

ABSTRACT WITHDRAWN...

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ea0073aep215 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Rare case of fluoroquinolone induced hypoglycaemia

Etchie Laju , Anwar Mehreen , Fernando Devaka , Poduval Ashok , Muraleedharan Vakkat

We would like to present an interesting unusual case of fluoroquinolone induced hypoglycaemia. As per FDA Adverse Event reporting System and medical literature published between 19872017, fluoroquinolones are said to have caused about 67 cases of life-threatening hypoglycaemic coma including 13 deaths and 9 permanent disabling injuries, most cases were associated with levofloxacin. Its hypoglycaemic effect is more common in elderly population who are on oral hypoglycaemi...

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ea0073aep216 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Microvascular complications in type 1 diabetes diagnosed during adulthood: prevalence and predictive factors

Faten Hadj Kacem , Boujelben Khouloud , Twaheerah Allymamod Bibi , Kawthar El Arbi , Nadia Charfi , Fatma Mnif , Mouna Mnif , Nabila Rekik , Mohamed Abid

IntroductionType 1 diabetes (T1D), also known as juvenile diabetes, commonly occurs in young individuals. However, autoimmune diabetes may be diagnosed in the elderly, with different clinical and biological aspects. The aim of our study is to identify the prevalence of and risk factors for microvascular complications related to T1D diagnosed during adulthood.Patients and methodsA retrospective study, from 201...

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ea0073aep217 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

In the context of acute disease does the same hyperlactatemia cut-off point hold similar meaning in patients with and without Diabetes mellitus? A retrospective study

Inês Vieira , Petrova Maja , José Moura

IntroductionHyperlactatemia is defined by a lactate value > 2 mmol/l and a lactate value above > 4 mmol/l is commonly used to define more severe hyperlactatemia. It is a common disorder in critically ill patients, associated with adverse prognosis. Diabetes mellitus (DM), however, can also be associated with increased lactate levels at baseline.ObjectivesTo document the development of severe hyperlact...

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ea0073aep218 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Utilisation of fibrosis-4 (fib-4 score) for screening non-alcoholic fatty liver disease (nafld) in women with type 2 diabetes (t2dm) in real world setting

Padhye Dakshata , Tanna Snehal , James Aleyamma , Nair Nithya

IntroductionLimited evidence exists for hepatic fibrosis in Type 2 Diabetes (T2DM). NAFLD is an independent risk factor for incident diabetes with trends towards increased risk in women.MethodsWe conducted a cross-sectional, retrospective analysis in 438 women with T2DM.FIB-4 score was used to estimate extent of incidental finding of liver fibrosis.ResultsMean fib...

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ea0073aep219 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Comparative evaluation of dapagliflozin and empagliflozin influence on the biomarkers of fibrosis and inflammation in patients with type 2 diabetes and very-high risk of cardiovascular events

Lebedev Denis , Babenko Alina

Recently, sodium-glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated cardioprotective effects. However, findings for major adverse CV events (MACE) outcomes with dapagliflozin are not concordant with the empagliflozin studies and the possible mechanisms of cardioprotective effects are not fully understood. The aim of the study was to compare the two distinct SGLT2i, empagliflozin and dapagliflozin, in their influence on the biomarkers of fibrosis and inflammation.</p...

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ea0073aep220 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Visceral adiposity index and atherogenic index of plasma: Simple markers of insulin resistance in type 2 diabetic patients

Kardi Asma , Oueslati Ibtissem , Yazidi Meriem , Hammami Bassem , Boukhayatia Fatma , Chaker Fatma , Feki Moncef , Chihaoui Melika

IntroductionHomeostasis model assessment for insulin resistance (HOMA-IR) is widely used as a marker of insulin resistance. However, it reminds an expensive maker requiring insulin dosage. Several studies tried to found simple alternative predictors of insulin resistance such as triglycerides to HDL-C ratio with conflicting reported findings. The aim of our study was to investigate the usefulness of the atherogenic index of plasma (AIP) and the visceral ...

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ea0073aep221 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Plasma angiopoietin-like 4 protein: Long term evolution after 3 different techniques of bariatric surgery

Guillermo Velasco de Cos , Diaz-Faes Angela Gonzalez , Ruiz Armando Guerra , Maguregui Ricardo Batanero , Lopez Elena Gonzalez , Coral Montalbán Carrasco , Bernardo Alio Lavín Gómez , María Teresa García-Unzueta , Luis Alberto Vázquez Salvi

Introduction Angiopoietin-like 4 protein (ANGPTL-4) is importantly produced in adipose tissue, mediates the inhibition of lipoprotein-lipase and has been recently related with the risk of atherosclerosis and type 2 diabetes (T2D). Bariatric surgery has demonstrated improvements in lipid profile, T2D and cardiovascular risk. But information about ANGPTL-4 circulating levels in severe obesity and after bariatric surgery is scarce.Obj...

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ea0073aep222 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Insulin resistance in association with cardiovascular risk factors and thyroid function

Kazukauskiene Nijole , Podlipskyte Aurelija , Varoneckas Giedrius , Narseta Mickuviene

Insulin resistance (IR) occurs as part of a cluster of cardiovascular-metabolic abnormalities. Given the seriousness of the cardiovascular diseases data there is the increasing burden of diabetes.The aim of the study was to investigate insulin resistant in association with cardiovascular risk factors among 4584-year-old citizens of Palanga.MethodsA randomized epidemiological study was performed with 850...

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ea0073aep223 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Free T4 level may be associated with insulin requirement in gestational diabetes mellitus

Ömercan Topaloğlu , Uzun Mehmet

IntroductionGestational diabetes mellitus (GDM) may frequently be overcome by nutrition therapy alone, but insulin regimen may be necessary in about 30 % of the patients with GDM. It was known that thyroid hormones were associated with glucose metabolism. Therefore, we aimed to investigate the association of fT4 level with insulin requirement in euthyroid pregnant women with GDM.Materials and methodsWe consec...

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ea0073aep224 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Treatment transition in a recently described HNF4a-MODY variant: Better late than never?

Barbosa Mariana , Lemos Manuel C. , Fernandes Vera

IntroductionMaturity Onset Diabetes of the Young (MODY) type 1 is characterized by mutations in hepatocyte nuclear factor 4a (HNF4a) gene, leading to progressive dysfunction of pancreatic beta-cells with optimal response to sulphonylurea treatment. However, most of these patients are initially misdiagnosed as having type 1 diabetes and inappropriately treated with insulin. Data on adequate transferring from insulin to sulphonylureas following gen...

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ea0073aep225 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The effect of obesity on the association between type 2 diabetes mellitus and polycystic ovary syndrome: a meta-analysis of observational studies

Anagnostis Panagiotis , Paparodis Rodis , Bosdou Julia , Bothou Christina , Macut Djuro P. , Goulis Dimitrios , Livadas Sarantis

ObjectiveThe exact risk of type 2 diabetes in women with polycystic ovary syndrome (PCOS) is unknown. It is also unclear if obesity independently increases the risk in this population. The aim of this study was to systematically review and synthesize the best available evidence regarding the association between PCOS and type 2 diabetes, stratified according to obesity status.MethodsA comprehensive search was ...

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ea0073aep226 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Features of bacterial metabolism of the colon in patients with type 2 diabetes mellitus (T2D) and non-alcoholic fatty liver disease (NAFLD)

Silvestrova Svetlana , Larissa Zvenigorodskaya , Alexander Petrakov

The key factor in the pathogenesis of both T2D and NAFLD is insulin resistance, which causes the lipids accumulation in hepatocytes and an increase of the lipid peroxidation, the production of reactive oxygen species and the development of inflammation. It has been shown that the main metabolic products of the saccharolytic microflora-short-chain fatty acids (SCFA), such as acetic (Ac), propionic (Pr) and butyric (Bu), can have an anti-inflammatory effect through their suppres...

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ea0073aep227 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Diabetes and cftr gene mutations: Prevalence and correlation in patients with cystic fibrosis

Mireia García-Ramírez , Ángel Rebollo-Román , Moreno-Moreno Paloma , Carlos-Manuel Alzás-Teomiro , Alfonso Calañas-Continente

AimTo establish a relationship between the severity associated with cystic fibrosis transmembrane conductance regulator protein (CFTR) mutations and the prevalence of abnormal glucose tolerance and diabetes in patients diagnosed with cystic fibrosis (CF).MethodsObservational, cross-sectional, clinical research in patients with CF evaluated at Hospital Universitario Reina Sofía (Córdoba).<p class...

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ea0073aep228 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Association of IDO polymorphism with oxidative status, metabolic control and inflammation in patients with type 2 diabetes mellitus

Neves Marta , Bicho Manuel , Santos Ana Carolina , João F. Raposo , Valente Ana

IntroductionThe Indoleamine 2.3-dioxygenase (IDO) is an enzyme involved in tryptophan metabolism, encoded by the IDO1 gene in humans. In Caucasians, the rs9657182 polymorphism of IDO gene was found to be associated with neurobehavioral complications, especially depression. Several studies in Type 2 Diabetes Mellitus (T2DM) describe psychological factors as barriers to the successful implementation of a healthy eating plan. According to our knowledge ther...

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ea0073aep229 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Treatment of psoriasis in patients with type 2 diabetes

Brutskaya-Stempkovskaya Elena , Shepelkevich Alla , Sushinski Vadim , Dydyshka Yuliya , Plotnikova Anastasia

Skin diseases in patients with type 2 diabetes mellitus (T2DM) are increased. Patients with T2DM and psoriasis have an increased risk of psoriasis exacerbations.Objective: to study the influence of T2DM on the psoriasis treatment.Materials and methodsWe studied hospitalized patients with T2D and psoriasis in dermatological clinic during 5 years (n = 47) - the main group. Compar...

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ea0073aep230 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Use of continuous glucose monitoring for control assessment in type 2 diabetes patients

Totomirova Tzvetelina , Arnaudova Mila , Lazova Maria

Continuous Glucose Monitoring (CGM) is proved to be useful for dose adjustment in patients treated with multiple insulin injection regimens or with continuous subcutaneous insulin infusion. CGM give precise information about glucose variability in type 1 diabetes but are rarely used in type 2 patients. We assessed continuous glucose monitoring systems (CGMs) as control assessment tool in patients with type 2 diabetes receiving different treatment regimens. We studied 85 patien...

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ea0073aep231 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Factors influencing pregnancy planning of women with diabetes

Ouafidi Btissam , Miski Fatiha El , Sabah Moukhlis , Maryem Bouab , Lamrissi Amine , Fichtali Karima , Bouhiya Said

IntroductionFor diabetics, preparation for pregnancy is essential; it allows conception in the best conditions, in order to reduce the risk of fetal malformation and abortion. The objective of this study is to determine the factors involved in pregnancy planning.Materials and methodsDescriptive retrospective study, including 200 patients with pre-gestational diabetes followed in the department of gynecology a...

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ea0073aep232 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Long-term testosterone therapy improves lipid profile in men with functional hypogonadism and overweight or obesity: 12-year observational data from a controlled registry study in a urological setting

Saad Farid , Haider Karim Sultan , Haider Ahmad

BackgroundEffects of testosterone therapy (TTh) on lipid parameters are inconsistent and may depend on treatment duration, route of administration, and adherence. While in short-term studies, testosterone usually lowers HDL, long-term studies seem to increase HDL. Total cholesterol, LDL and triglycerides are either reduced by TTh, or effects are neutral.Material and methodsAfter excluding men with primary hyp...

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ea0073aep233 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Efficacy and safety of gp40081 (insulin aspart biphasic 30) compared to novomix 30 flexpen in type 2 diabetes mellitus patients

Isaeva Julia , Makarenko Igor , Vinderskaya Galina , Magruk Maksim , Drai Roman

IntroductionA biosimilar is a biological medicinal product that shows high similarity to another already approved medicine product containing biotechnology-derived protein as active substance. The similarity depends on the biosimilar development program that includes comparative studies of physical and chemical properties, in vitro pharmacodynamics, pharmacokinetics and pharmacodynamics in humans. Insulin aspart biphasic 30 is one of the most co...

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ea0073aep234 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Vildagliptin is a safe and powerful oral antidiabetic drug for elderly adults with type 2 diabetes

Mahapatra Hariballav , 2 Laxminarayan Mahapatra , Khuntia Monalisa , Sahoo Abhay Kumar , Sucharita Soumya

DPP4 inhibitors are special class of drugs that not only improve metabolism in a glucose dependant manner, but also suppress the glucagon axis. Due to its glucose dependant insulinotropic action, vildagliptin is thought to be relatively safe for people who are at risk of developing low glucose episodes. We studied the glucose lowering potential and hypoglycemic effects of vildagliptin among elderly diabetics who were uncontrolled with at least 2 oral antidiabetic medications. ...

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ea0073aep235 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The relation between cortisol and anthropometric measurements throughout lifespan: A systematic review and meta-analysis

Eline van der Valk , Abawi Ozair , Mohseni Mostafa , Abdelmoumen Amir , Wester Vincent , Bibian van der Voorn , Iyer Anand , Erica van den Akker , Hoeks Sanne , Rijke Yolanda de , Stalder Tobias , Rossum Elisabeth van

IntroductionRecently, cross-sectional studies report associations between long-term glucocorticoid levels in scalp hair (HairGC) and obesity. However, there is a wide variation in studied outcomes and associations, possibly caused by differences in population characteristics, e.g. age, sex, dispersion of adiposity, and used laboratory methods. The aim of this systematic review and meta-analysis was to investigate the relation between HairGC and anthropom...

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ea0073aep236 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The intensity of menopausal hot flushes is associated with values of the hepatic steatosis index

Armeni Eleni , Augoulea Areti , Paschou Stavroula , Karagkouni Iliana , Mili Nikoletta , Kontou Lorena , Kaparos Georgios , Rizos Dimitrios , Panoskaltsis Theo , Lambrinoudaki Irene

IntroductionMenopausal transition is associated with an increase in the cardiovascular risk, possibly related with the sharp decrease of estrogen levels. Menopausal symptoms and more specifically hot flushes have been previously linked with an increase in cardiovascular risk. On the other hand, non-alcoholic fatty liver disease is considered as another presentation of the metabolic syndrome, conferring additional cardiovascular risk to the affected indiv...

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ea0073aep237 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Elevated circulating cell-free deoxyribonucleic acid in obese individuals

Chiboub Marwa , Mnif Fatma , Gargouri Imen , Chaaben Kais , Mohamed Abid , Boutheina Cherif

IntroductionAltered levels of circulating cell-free deoxyribonucleic acid (ccf DNA) have been found in several pathologies and might have a diagnostic value. With the steadily growing number of studies in the issues related to obesity research, it is proven, that obesity might be related to wide number of body disorders. In the current opinion, we hypothesized that there is a correlation between obesity and elevated cfDNA levels in the circulation.<p...

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ea0073aep238 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effect of a 16-week physical activity program on body composition and aerobic capacity parameters in a population of obese youth

Safi Wajdi , Mejdoub Nabila Rekik , Mohamed Abdellahi Mohamed Ahmed , S. Regaieg , M. Kamoun , H. Elleuch , H. Rebai , M. Mnif Feki , N. Charfi , Abid Mohamed

IntroductionThe prevalence of childhood obesity continues to increase nowadays but also its long-term complications, particularly metabolic and cardiovascular, and this is due in large part to all the current modern conditions and means that promote sedentary lifestyle and lack of physical activityMaterial and methodsWe developed a 16-week aerobic exercise program (four 60-minute sessions per week at 70...

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ea0073aep239 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The efficacy of complex kinesiotherapy in weight loss and improving of carbohydrate metabolism in obesity patients

Vasileva Valeriia , Marchenkova Larisa , Eryomushkin Mikchail

Aim of the study was to estimate the effect of complex with 4 kinesiotherapy methods on body weight loss and carbohydrate metabolism in patients with obesity.Material and methods. 80 people were enrolled in the study. 40 people in the first group (G1) -5463 years old with obesity (mean age 57 [54;63] years, weight 100.5 [89.5;114.8]kg, BMI 35.6 [32.8;43.2] kg/m2, waist circumference WC 105.5 [100.3...

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ea0073aep240 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Impact of sleeve gastrectomy on uric acid metabolism in a Tunisian obese group

Imene Hedfi , Mahjoub Faten , Amor Nadia Ben , Mizouri Ramla , Olfa Berriche , Henda Jamoussi

IntroductionFacing the repeated failures of the medical management of obesity, bariatric surgery offers a promising therapeutic option in terms of achieving weight loss and metabolic benefits. Our study aimed to assess the impact of sleeve gastrectomy on uric acid metabolism in obese subjects.MethodsThis was a repeated retrospective cross-sectional study including 40 obese patients who were followed up at the...

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ea0073aep241 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

GLP-1 receptor agonists and bariatric surgery in nonalcoholic steatohepatitis

Soraya León , María Dolores Alcántara-Laguna , Maria José Molina , Alfonso Jesús Calañas Continente , Concepción Muñoz , Maria Angeles Galvez Moreno , Aura D. Herrera-Martínez

RationaleObesity is associated with multiple comorbidities including nonalcoholic steatohepatitis (NASH). Despite its association with increased morbidity and mortality, treatment options are limited. Some studies have suggested that glucagon-like peptide-1 receptor agonists (aGLP-1) are associated with NASH resolution. Additionally, the effects of bariatric surgery on NASH-associated liver fibrosis are controversial.Methods<p ...

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ea0073aep242 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Post hip-fracture rehabilitation outcomes of diabetic and non-diabetic elderly patients

Ben-Joseph Ronen , luboshitz Barak , Heffez-Ayzenfeld Rachel , Twito Orit

BackgroundAlthough patients with diabetes mellitus (DM) are at higher risk of hip fracture, data regarding the effect of DM on rehabilitation outcomes is limited.MethodsA retrospective population-based study was conducted comparing diabetic and non-diabetic elderly patients with a recent hip fracture who were admitted to a geriatric rehabilitation facility during 20142019. The Functional Independence Me...

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ea0073aep243 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Impact of supervised physical activity on cardiovascular autonomic status in type 2 diabetes patients

Stirane Laura , Stirans Karlis , Pahirko Leonora , Mednieks Janis , Sokolovska Jelizaveta

BackgroundCardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus (DM) that is strongly associated with increased risk of cardiovascular mortality. The significance of CAN has not been fully appreciated. Treatment of CAN includes physical activity.AimTo detect CAN status and measure the influence of physical activity on the autonomic nervous system using cardiovascular autonomic refl...

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ea0073aep244 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Optimization of surgical treatment of patients with diabetic foot syndrome

Andrew Burak

BackgroundThe development of purulent-necrotic complications of the lower extremities is one of the most dangerous complications of diabetes. According to the Internationale Diabetes Federation, the number of hospitalized patients with foot lesions due to diabetes is 2547%, and subsequently causing high amputations in 12% of such patients. That is why the comprehensive approach of the surgeon and endocrinologist is the key to successful treatment o...

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ea0073aep245 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Necrotizing external otitis in diabetic patients: Role of imaging

Masmoudi Mohamed , Hasnaoui Mehdi , Sara Lazid , Wadii Thabet , Khalifa Mighri

PurposeTo describe the role of imaging in diagnosis and detection of complications of necrotising external otitis in diabetic patients.Material and methodsOur retrospective study included 43 diabetic patients who suffered from necrotising external otitis, from 1992 to 2020. All our patients had CT scan of the temporal bones and the brain. MRI was performed in 4 cases.Results<p class...

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ea0073aep246 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Risk factors associated with diabetic foot amputation among patients hospitalized for diabetic foot ulcer in a public hospital

Gutu Olga , Vasques Miguel , Inês Manique , Amaral Sara , Bruno Bouça , Prokop Joanna , Ana Cláudia Martins , António Afonso , José Neves , Silva-Nunes Jose

IntroductionDiabetic foot is one of the most devastating of chronic complications of diabetes mellitus (DM) and is responsible for about 25% of hospitalizations. Worldwide, the diabetic foot represents the main cause of non-traumatic lower limb amputation.Aim of the studyIdentification of risk factors for foot amputation among in patients hospitalized for diabetic foot in a tertiary public hospital in Portuga...

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ea0073aep247 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Clinical characteristics and outcomes of elderly type 2 diabetic patients with SARS-COV2 infection: a retrospective single centre study

Bárbara Filipa Araújo , Cátia Andreia Araújo , Melo Miguel , Lavrador Mariana , Elvas Ana Rita , Diana Alexandra Festas Silva , Guiomar Joana Reis , Paiva Sandra , PAIVA Isabel

IntroductionDiabetes mellitus (DM) and older age are frequent comorbidities as well as factors associated with poorer outcomes in patients with Coronavirus disease (COVID-19). The reason for worse prognosis in patients with diabetes is likely to be multifactorial.Objectives We aimed to evaluate clinical characteristics and their impact on the outcomes of elderly patients with and without DM hospitalized with ...

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ea0073aep248 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effect of coronavirus disease on the clinical course of diabeticketoacidosis (DKA) in people with type 1 and type 2 diabetes

Melson Eka , Kempegowda Punith , Johnson Agnes , Wallett Lucy , Thomas Lucretia , Zhou Dengyi , Holmes Catherine , Juszczak Agata , Karamat Muhammad , Ghosh Sandip , Hanif Wasim , Narendran Parth , Bellary Srikanth

IntroductionCoronavirus disease (COVID-19) in people with diabetes is associated with a disproportionately worse prognosis. DKA is an acute complication of diabetes with a mortality rate of approximately 0.67%. Little is known about natural history of DKA in the presence of COVID-19 infection. This study aimed to explore the effects of COVID-19 infection on presentation, clinical course and outcome in patients presenting with DKA.M...

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ea0073aep249 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Efficacy of liraglutide in weight reduction in a patient with HAIR-AN syndrome - case report

Wasyluk Weronika , Joanna Świrska , Matyjaszek-Matuszek Beata , Zwolak Agnieszka

HAIR-AN is a rarely recognized syndrome which is characterized by hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). In the course of the syndrome, anovulation and metabolic disorders can develop, too. It is therefore suggested by some authors that HAIR-AN is an extreme phenotype of the polycystic ovary syndrome (PCOS). Generally, considering wide spectrum of metabolic and endocrine disorders which can be associated with the syndrome, it still remain...

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ea0073aep250 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Evaluation of the results of weight loss at 1 year after bariatric surgery at the regional university hospital of malaga

Silvia Patricia Alonso Gallardo , Viyey Kishore Doulatram Gamgaram , José Abuín Fernández , Marin Montserrat Gonzalo , Sergio Valdés Hernández

IntroductionMorbid obesity is a very prevalent disease, bariatric surgery being a fundamental pillar in its treatment.ObjectiveTo analyze the results of weight loss at 1 year in patients operated on gastric bypass and sleeve at the Regional University Hospital (HRU) of Malaga.MethodsRetrospective observational study, with a follow-up period of 1 year, of 215 patie...

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ea0073aep251 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Bupropion/naltrexone associated psoriasis in an obese patient

Sara Campos Lopes* , Regina Caldas* , Maria José Guimarães , Areal Joana , Alves Marta , Pereira Teresa

*These authors contributed equally to this workIntroductionThe prevalence of obesity has risen dramatically worldwide in the last three decades. Due to this obesity pandemic, a growing demand for weight-loss drugs has emerged. The increased use of these drugs has consequently lead to an increase in the report of adverse reactions.Case reportA 45-year-old woman with past medical history ...

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ea0073aep252 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Inhibition of ATG3 ameliorates liver steatosis by increasing SIRT1 in an autophagic-independent action

Novoa Eva , Nátalia da Silva Lima , Marcos Férnandez Fondevila , Buque Xabier , María Jesús González Rellán , Uxía Fernández Paz , María García Vence , María del Pilar Chantada Vázquez , Bravo Susana , Patricia Marañon , Escudero Adriana , Leiva Magdalena , Fidalgo Miguel , Gomes Pedro , Claret Marc , Sabio Guadalupe , Rey Marta Varela , Delgado Teresa , Miguel López , Carlos Diéguez , María Martínez Chantar , Carmelo García Monzon , Agueda González Rodríguez , Aspichueta Patricia , Rubén Nogueiras Pozo

Background and aimsNonalcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases including nonalcoholic steatohepatitis (NASH), liver cirrhosis and liver cancer. One of the numerous molecules participating in the development of liver steatosis is p63. Although p63 is mainly known for its roles as a tumor suppressor and cell maintenance and renewal, we ha...

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ea0073aep253 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Association between obesity and anxiety: A cross-sectional study in Sfax, Southern Tunisia

Mejdoub Yosra , Maamri Hanen , Salah Dhoha Ben , Ketata Nouha , Mondher Kassis , Sourour Kammoun , Elleuch Mouna , Dammak Jamel , Jdidi Jihen , Mohamed Abid

IntroductionObesity is recognized to be one of the greatest public health problems worldwide. In addition to physical health problems, obesity is also linked to an increased risk of mental health disorders such as anxiety. The objective of this study was to determine the prevalence of anxiety in obese adults and the factors associated with anxiety in this population.MethodsWe conducted a cross-sectional study...

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ea0073aep254 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Characterization of glycemic profile and glucose-lowering treatment in hospitalized patients of a central hospital by main diagnosis and length of stay

Patrícia Rosinha , Teixeira Sofia , Cláudia Amaral , Cardoso Helena

IntroductionGlycemic control during hospitalization has an impact on the length of hospital stay (LOS) and infection rates. This knowledge has led to a growing concern with hyperglycemia and its repercussions.ObjectivesThis study aims to evaluate the glycemic profile and diabetes mellitus (DM) treatment paradigm of hospitalized patients in a central hospital by main diagnosis and LOS.Me...

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ea0073aep255 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Audit on GLP-1 mimetics monitoring in East Kent university hospitals UK

Musa Abdelmajid , Alkundi Alamin

Aims/objectivesThe aims of the audit were to assess the monitoring of GLP-1 analogues if they were in accordance in monitoring to National institute of clinical excellence guidelines and appropriate in continuation and 6 months review with these guidelines.MethodsA retrospective audit of 81 patients with Type 2 diabetes who were taking GLP-1 analogues between January 2010 and July 2019 at East Kent university...

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ea0073aep256 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Real-world experience of Evolocumab for treatment of hyperlipidemia in an outpatient population

Iqbal Sajid , Tikriti Alia Al , Buckley Adam

BackgroundUse of Evolocumab as a monotherapy or in combination with other lipid lowering drugs reduces LDL-C by up to 60% in patients with or without familial hypercholesterolemia (FH), diabetes mellitus (DM), or coronary artery disease (CAD). Data regarding the efficacy of PCSK9 inhibitors in MENA populations is lacking.MethodRetrospective case review of all patients initiated on Evolocumab treatment at Impe...

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ea0073aep257 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The optimal HbA1c threshold for predicting diabetes mellitus defined by OGTT in a high-risk population in Algiers about 500 cases

Belkacem Samira

IntroductionType 2 diabetes mellitus chronic hyperglycemia resulting from a defect in the secretion of insulin or the action of insulin or from these two associated abnormalities.Aim of the studyTo try to establish an optimal threshold of HbA1C to predict diabetes mellitus on a sample of Algiers population not known to be diabetic but at high risk compared to the gold standard OGPO.Meth...

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ea0073aep258 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

HbA1c threshold to predict prediabetes in a non-diabetic population but high risk of diabetes

Belkacem Samira

IntroductionWhen we talk about the prevalence of diabetes on a planetary scale, we can speak of a global epidemic or even a pandemic. Its prevalence continues to increase and the detection of individuals at risk of developing this disease remains a major concern.Aim of the studyTo attempt to establish standards for HbA1c by assessing the validity of this test in the diagnosis of pre-diabetic conditions and in...

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ea0073aep259 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Clinical and immunological profile of newly diagnosed diabetic patients in a cohort of young adults of national hepatitis C Virus survey in Egypt

Hendawy Laila , Halawa Mohamed , Eid Yara , Elhalawany Salah , Hegab Ahmed

BackgroundType 2 diabetes has traditionally been considered a disease affecting older age groups. In recent years, however, Type 2 diabetes has become increasingly common in children, adolescents and young adults.Aim of the workTo estimate the prevalence of T2D among a sample of Egyptian youth aged (1830) and to highlight the challenges in differentiating T1D from T2D in early onset diabetes depending o...

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ea0073aep260 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The role of bile acids in the pathogenesis of non-alcoholic fatty liver disease and type 2 diabetes mellitus

Larissa Zvenigorodskaya , Alexander Petrakov , Tamara Nilova , Mikhail Shinkin

Bile acids (BA) regulate glucose and lipid metabolism, provide bile flow, increase lipase activity by 1015 times. With the development of inflammation, violations occur in the membrane proteins of glucose transporters.AimDetermine the total pool of bile acids in NAFLD with diabetes mellitus (DM) and impaired glucose tolerance (IGT). Determine the content of inflammation markers lipoprotein-associated phospholipase (Lp-PLA2), ...

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ea0073aep261 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Self-Management Behavior of the Patients with Type 2 Diabetes: A Cross-Sectional Survey in the Eastern European population (Belarus)

Yaroma Andrei , Danilova Larissa I.

BackgroundThe prevention of complications and improvement of metabolic control and state of health in diabetes cannot be effective only with medications. And now we need to develop different approaches not only up to date pharmacological treatment of diabetes, but change the Self-Management Behavior among patients with Type 2 Diabetes.AimsTo assess the current status of diabetic self-management behavio...

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ea0073aep262 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Retinol-binding protein in the diagnosis nafld and type 2 diabets

Larissa Zvenigorodskaya , Tamara Nilova , Alexander Petrakov , Varvanina Galina , Mikhail Shinkin

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes andnon-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates th...

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ea0073aep263 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Study on INS gene rs689 polymorphism in patients with diabetes mellitus genetic burden

Saatov Talat , Ibragimova Elvira , Ibragimov Zafar , Alimova Nasiba , Ishanhodjaev Tokhir , Zainutdinov Bakhodyr , Tashtemirov Abdunabi , Babaev Kudrat , Shamansurova Zulaykho

Testing for genetic markers is a promising approach in early diagnosis of type 1 diabetes mellitus (DM1). Of all DM1-associated genes and genetic loci, after HLA class II, insulin promoter gene confers the highest risk for the onset of disease with the burdened familial history for diabetes mellitus.Materials and methodsGenealogical analysis was used to identify the hereditary nature of the disease. DNA samples from 94 Uzbek patien...

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ea0073aep264 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Treatment recommendations for dapagliflozin across a cardio-renal and viscero metabolic (crv-m) continuum: an expert consensus delphi study

Das Ashok , Awasthi Rajeev , Sahay Manisha , Sahoo Abhay , Hazra Prakash , Kapoor Nitin , Tiwaskar Mangesh , Bhandarkar Prashant , Sahay Rakesh , Bhattacharya Saptarshi , Saboo Banshi , Pandit Kaushik , Kishor Kamal , Marwah Tiven , Agrawal Navneet , Sharma Kamal , Khanna Umesh , Bantwal Ganapathi , Joshi Ameya , Kerkar Prafulla , Kalra Sanjay

IntroductionDapagliflozin is sub-optimally utilised in the real world. There is a lack of a comprehensive collaborative guidance for a practical approach to manage patients with cardiometabolic, renometabolic and viscerometabolic disorders. Patients across the CRV-M continuum includes patients with varied clinical profiles.MethodsTwo round Delphi study was conducted using a virtual online-digital connect appr...

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ea0073aep265 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Acute fatty liver of pregnancy masquerading as diabetic ketoacidosis

Anwar Mehreen , thant Yamin , Sardar Muhammad Shoaib Khan , Muhammad Athar Iqbal Khan

Acute fatty liver of pregnancy (AFLP) is a rare obstetric metabolic emergency (UK incidence 1/20.000 maternities) which typically presents in 3rd trimester or postpartum and has a high maternal and foetal mortality and morbidity (UK Maternal mortality 1.8%, perinatal mortality 104/1000 births). Diagnosis can be delayed due to lack of set diagnostic criteria, rarity and overlapping clinical presentation with many other obstetric metabolic pathologies. Urgent delivery...

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ea0073aep266 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

To assess the glucose metabolism using the flash glucose monitoring system (FGMS) in patients with hormone replacement therapy for hypopituitarism

Jiaxin Zhang1 , Qiong He1 , Minmin Han1 , Jie Li1 , Dan Yang1 , Xintong Hou1 , Guimei Yang1 , Jing Yang1 , Yunfeng Liu1 , Yi Zhang2

BackgroundHormone replacement therapy is often used for hypopituitarism, which leads to dysglycemia. This study is conducted to assess the glucose metabolism conditions using the flash glucose monitoring system (FGMS) in patients with hormone replacement therapy.MethodSeven patients who were diagnosed as hypopituitarism and treated with glucocorticoids and L-Thyroxine were qualified to participate in this stu...

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ea0073aep267 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

p63 induces the fibrosis in NASH

Fondevila Marcos F , Novoa Eva , Uxía Fernández , María J González-Rellán , Lima Natalia , Begoña Porteiro , Juan Cuñarro , Tovar Sulay , Fidalgo Miguel , Martinez-Chantar Maria Luz , Sabio Guadalupe , Marcos Miguel , Lopez Miguel , Dieguez Carlos , Rubén Nogueiras

p53 family controls several metabolic and cellular functions. The p63 member regulates lipid metabolism in hepatocytes and contributes to the development of liver steatosis. Here we show that p63 plays an important role in liver fibrosis. P63 is upregulated in patients with NASH, correlating positively with fibrosis score and collagen 1a1 expression. P63 expression is also increased in different animal models of diet-induced NASH and chemically induced liver fibrosis. Mice wit...

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ea0073aep268 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Challenges in availability of insulin in Malwa region of Madhya Pradesh, INDIA during COVID-19 lockdown and its impact on perceived stress in patients

Saboo Bharat

IntroductionThere are large number of patients of diabetes who require insulin to control their blood sugar. During the covid 19 lockdown, many medicines were not easily available and insulin being a life-saving and necessary medicines requires smooth availability. Non availability of insulin causes sugar fluctuations and anxiety in minds of patients and attendants and can affect well-being.MethodsWe surveyed...

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ea0073aep269 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Factors predictive of glycemic control of pregnant diabetic women

Miski Fatiha El , Ouafidi Btissam , Sabah Moukhlis , Maryem Bouab , lamrissi Amine , Fichtali Karima , Bouhiya Said

IntroductionDiabetic pregnancy is an at-risk pregnancy, hence the importance of perfect glycemic control. The objective of this study is to evaluate glycemic control of pregnant women and these intervening factors.Materials and methodsOur study is prospective observational and analytical, including 300 patients with diabetic pregnancy followed in the obstetric gynecology department of Ibn Rochd hospital in Ca...

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ea0073aep270 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Correlation between cystatin C and cardiovascular risk factor in patients with type 2 diabetes mellitus without kidney disease

Risovic Ivona , Vlastimir Vlatkovic2 , Pejicic Snjezana Popovic , Grbic Aleksandra , Malesevic Gabrijela

IntroductionDiabetes mellitus (DM) is considered as equivalent to cardiovascular disease (CVD), so the intensive control of all risk factors for CVD in patients with DM is recommended. Risk factors for CVD include: dyslipidemia, hypertension, smoking, family history of CVD and albuminuria. In addition to being a sensitive and reliable marker for evaluation of kidney function, research suggests that cystatin C may be a useful predictor for the detection a...

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ea0073aep271 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Role of diabetic autonomic neuropathy in development of diabetic cardiomyopathy in patients with diabetes

Pejicic Snjezana Popovic , Pejicic Nina , Malesevic Gabrijela , Stankovic Valentina Soldat , Risovic Ivona

AimDiabetic cardiomyopathy (DC) is congestive heart failure developed in diabetic patients, without coronary, hypertensive, valvular nor myocardial alcoholic disease. Aim of this stady was to confirm if presence of diabetic autonomic neuropathy (DAN) is correlating with development of DC in patients with diabetes.MethodsWe have evaluated 90 examinees: 30 of them with diabetes type 1(T1D), 30 with diabetes typ...

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ea0073aep272 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Influence of nutritional status on clinical outcomes among hospitalized patients with covid-19

Keyla María Dotres Fallat , Nicolau Joana , Corao Luisa Ayala , Pilar Sanchís Cortés , Irene Rodríguez Rodríguez , Ana Gloria Soler Beunza , Romano Andrea Pompeo , Lluís Masmiquel Comas

Background and aimsSeveral factors that worsen the prognosis of the new coronavirus SARS-CoV-2 have been identified, such as obesity or diabetes. However, despite that nutrition may change in a lockdown situation, little is known about the influence of malnutrition among subjects hospitalized due to COVID-19. Our study aimed to assess whether the presence of malnutrition among patients admitted due to COVID-19 had any impact on clinical outcomes compared...

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ea0073aep273 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Acute hyperglycemic emergencies during lockdown: COVID-19 collateral damage

Bárbara Filipa Araújo , Cátia Andreia Araújo , Lavrador Mariana , Elvas Ana Rita , Paiva Sandra , PAIVA Isabel

IntroductionIn march 2020, the COVID-19 pandemic registered its first cases in Portugal, leading the government to impose lockdown, in order to prevent the spread of cases. With social isolation and outpatient activity being ceased, there was an increase in mortality of non-COVID patients. The lockdown recommendations are in contradiction with comprehensive diabetes care and reflected in less regular patient-provider interactions, which in some cases con...

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ea0073aep274 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Sex-specific variations in lipid concentrations following a low-fat diet are mediated by vitamin D status: a 12-week prospective dietary intervention study among Christian Orthodox fasters

Karras Spyridon , Koufakis Theocharis , Adamidou Lilian , Dimakopoulos Georgios , Karalazou Paraskevi , Thisiadou Katerina , Bais Alkiviadis , Tzotzas Themistoklis , Makedou Kali , Manthou Eleni , Kotsa Kalliopi

BackgroundOrthodox religious fasting (OF) is a variation of the classical Mediterranean Diet during which meat and other animal products are restricted, whereas fish are occasionally and sea food are always allowed. The aim of this prospective study was to assess sex-specific differences in changes of lipid concentrations in a cohort of metabolically healthy adults following OF and investigate a potential role of vitamin D status in mediating these varia...

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ea0073aep275 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Low-density lipoprotein cholesterol target achievement in patients with diabetes

Hakiri Ghofrane , Htira Yosra , Dridi Manel , Ali Zohra Hadj , Mami Faika Ben

BackgroundDiabetes is often associated with other cardiovascular (CV) risk factors such as dyslipidemia, wich increases the risk of degenerative disease and contributes to elevate morbi-mortality in these patients. The aim of this study was to assess the CV risk level of diabetic patients and to determine the rate of lipid targets achievement.Methodsit was a descriptive cross-sectional study including 100 dia...

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ea0073aep276 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Heterozygous familial hypercholesterolemia with intolerance to PCSK9 inhibitors

Saraiva Miguel , Palma Pedro , José Alexandre Queirós , Palma Isabel

IntroductionHeterozygous familial hypercholesterolemia is one of the most common genetic disorders and it is associated with an at least ten times higher risk of coronary heart disease. Frequently, it is necessary to medicate the patients with PCSK9 inhibitors (PCSK9i) so they can reach LDL-c target values. In Portugal, the only evolocumab is available and the most commonly reported adverse effects are local pruritus and upper airway symptoms.<p clas...

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ea0073aep277 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Frequency of obesity among individuals with spondylarthritis

Khaoula Ben Ali , Slouma Maroua , Zouaoui Chadia , Gharsallah Imen

BackgroundSpondylarthritis may be associated with substantial burden of comorbidities, which can increase the cardiovascular risk. Obesity if associated with spondylarthritis not only can rise the risk of a possible heart disease but it may also deteriorate their functional prognosis.ObjectivesThe main target of this study was to evaluate the frequency of obesity in spondylarthritis patients.<p class="abs...

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ea0073aep278 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Response to direct antiviral agents in chronic hepatitis C in patients with metabolic syndrome

Soumaya Mrabet , raida harbi , Akkari Imen , Elhem Ben Jazia

IntroductionDirect antiviral agents (DAAs) are a real revolution in the treatment of chronic hepatitis c (CHC). It is a short-term treatment with few side effects. Insulin resistance in patients with metabolic syndrome, causes the onset of steatosis, contributes to the progression to cirrhosis and decreases the chances of a response to treatment. The aim of our study was to evaluate the response to DAAs in patients with metablic syndrome.<p class="ab...

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ea0073aep279 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The gut microbiota phylotypes in obese patients with arterial hypertension and pre-diabetes

Koval Sergiy , Snihurska Iryna , Yushko Kostiantyn

Gut microbiota, its phylotypes, the Firmicutes/Bacteroidetes ratio can play important role in the pathogenesis of arterial hypertension, obesity and metabolic disorders. The aim of the study was to evaluate the content of the main phylotypes of the gut microbiota (Firmicutes, Bacteroidetes and Actinobacteria), the Firmicutes/Bacteroidetes ratio in patients with arterial hypertension, abdominal obesity and pre-diabetes.Materials and...

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ea0073aep280 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effects of Glucagon-Like-Peptide-1 analogue treatment in genetic obesity

Welling Mila , Groot Cornelis de , Kleinendorst Lotte , Bibian van der Voorn , Burgerhart Jansteven , Eline van der Valk , Haelst Mieke van , Erica van den Akker , Rossum Elisabeth van

IntroductionObesity is highly prevalent, comes with serious health burden and is difficult to treat. In a minority, there is a genetic cause for the obesity. In these patients, therapy-resistant obesity is often observed despite intensive lifestyle treatment. Moreover, it is still unclear whether bariatric surgery is less successful in genetic obesity. Liraglutide is a Glucagon-Like-Peptide-1 (GLP-1) receptor agonist or GLP-1 analogue, showing positive e...

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ea0073aep281 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effect of elevated hemoglobin A1c on complication rates after bariatric surgery: a retrospective cohort study

Theel Willy , Wiebolt Janneke , Eskes Silvia , Klessens Francoise

ObjectiveThe aim of this study is to evaluate whether an increased preoperative hemoglobin A1c (HbA1c) is a risk factor for postoperative complications.MethodsWe retrospectively reviewed a database of patients who underwent a laparoscopic sleeve gastrectomy or a laparoscopic gastric bypass. The database was split into two cohort according to the preoperative HbA1c (> or ≤ 7 mmol/l).<p class="abs...

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ea0073aep282 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Role of sarcopenia in cognitive function in patients with morbid obesity before bariatric surgery

Andreu Simó-Servat , Ibarra Montserrat , Libran Mireia , Valverde Maite , Perea Veronica , Luis García-Pascual , Orois Aida , Carmen Quirós , Casas Laura , Maria Jose Barahona Constanzo

AimObesity was shown to be related to global cognitive decline, being especially altered the executive function and the information processing speed. Additionally, sarcopenic obesity (SO) was associated independently with a deterioration in global cognition, executive function, information processing speed, global memory and cerebral atrophy in patients > 65 years. However, at present there is no data regarding the role of sarcopenia in the cognitive...

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ea0073aep283 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Diabetic nephropathy in absence of diabetic retinopathy in type 2 diabetes mellitus patients

Khalaf Rahma , Ali Zohra Hadj , Htira Yosra , Mami Faika Ben

BackgroundThere is a well-recognized association between diabetic retinopathy (DN) and diabetic nephropathy (DN), in which nephropathy without retinopathy is rare but retinopathy without nephropathy is common.AimTo highlight the discordance between retinopathy and nephropathy and describe a series of patients with diabetic nephropathy who had no evidence of diabetic retinopathy.Methods<...

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ea0073aep284 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Management of emphysematous pyelonephritis: Report of Two Cases

Bel Hadj Sliman Chayma , Ayari Sabrina , Najla Bchir , Chadia Zouaoui , Haroun Ouertani

IntroductionEmphysematous pyelonephritis (EPN) is a necrotizing infection of the renal parenchyma which occurs preferentially in diabetics and is fraught with heavy mortality. Adequate therapeutic management is controversial: medical or surgical, conservative or radical. We report two observations of emphysematous pyelonephritis in two female diabetic patients, aged 58 and 50 years old, respectively.Observation<p class="abstext...

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ea0073aep285 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Association of metabolic syndrome and hepatic steatosis in type 2 diabetics

Malki Abdessamad , Najoua Messaoudi , Assarrar Imane , Rouf Siham , Latrech Hanane

IntroductionMetabolic steatopathy or non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) are common diseases that regularly coexist and can act in synergy by increasing the risk of metabolic complications and cardiovascular events. NAFLD seems to be frequently associated with metabolic risk factors reflecting the metabolic syndrome. The aim of this study is to analyse the characteristics of this association in type 2 diabetics.<p cla...

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ea0073aep286 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Brain perfusion in patients with type 1 diabetes and cognitive dysfunction

Matveeva Mariia , Samoilova Julia , Tonkih Olga

Purpose of the studyEvaluation of cerebral microcirculation using contrast and non-contrast magnetic resonance perfusion in patients with type 1 diabetes and cognitive dysfunction.Material and methodsThe study complied with generally accepted ethical rules. The study included 45 patients with type 1 diabetes mellitus with cognitive dysfunction and 20 patients without. All patients were continuously monitored ...

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ea0073aep287 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Predictive factors associated with diabetic kidney disease in adult-onset Type 1 Diabetes

Faten Hadj Kacem , Boujelben Khouloud , Twaheerah Allymamod Bibi , Wajdi Safi , Fatma Mnif , Mouna Mnif , Nadia Charfi , Nabila Rekik , Mohamed Abid

IntroductionUncontrolled hyperglycemia of diabetes is a common cause of renal failure and diabetic nephropathy, which is also called diabetic kidney disease (DKD). Despite improvements in the management of type 1 diabetes (T1D), progression of diabetic nephropathy remains unpredictable and associated with high morbidity and mortality. The objective of this study is to assess the prevalence and risk factors for diabetic kidney disease among adults-onset T...

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ea0073aep288 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The impact of printed educational materials on knowledge in women with gestational diabetes mellitus

Staynova Radiana , Vasileva Emanuela

AimTo evaluate the impact of printed educational materials on knowledge in women with gestational diabetes mellitus (GDM).Materials and methodsA randomized controlled trial was performed among women with GDM. A total of 135 pregnant women with GDM who attended antenatal clinic were randomly assigned to either an intervention (45 pregnant women) or a control group (90 pregnant women). The women from interventi...

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ea0073aep289 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The effect of empagliflozin on main cardiovascular risk factors in patients with type 2 diabetes with normal and excessive body weight

Didushko Oksana , Kobrynska Olena

AimStudy the efficacy of empagliflozin effects on main cardiovascular risk factors in non-insulin-dependent diabetic patients with normal and excessive body weight.Objectives60 patients with type 2 diabetes who have been taking metformin for at least 6 months but havent reached the target level of glycated haemoglobin (HbA1c), as well as 10 healthy individuals were examined. Depending on the prescribed ...

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ea0073aep290 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Gestational diabetes:predicting factors for switch to insulin

Bargaoui Zeineb , Ali Zohra Haj , Salem Amal , Htira Yosra , Mami Faika Ben

IntroductionInsulin therapy in gestational diabetes (GD) is the second line of therapy after failure of diet rules (DR). The aim of our study was to determine the predictive factors for switching to insulin in gestational diabetes.MethodThis is a descriptive cross-sectional retrospective study, including 82 patient files followed at the gestational diabetes unit of the National nutrition institute.<p clas...

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ea0073aep291 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Clinical research out of insulin glargine u300 in type 1 diabetes mellitus patients with frequent hypoglycemia: a real world experience

Kisioglu Savas Volkan , Demir Ahmet Suat , Tufekci Damla , Gunay Yasemin Emur , Coskun Hulya , Ucuncu Ozge , Nuhoglu Irfan , Kocak Mustafa , Karakullukcu Serdar , Ersoz Halil Onder

Aims/IntroductionWe aimed to see whether Insulin Glargine U300 can provide better blood glucose control while reducing hypoglycemia in a more homogeneous population compared to previous studies.Materials and methodsFor evaluation of FBG, HbA1c and weight at 6 months and all variables final, observation windows of 120240 days (48 months) and 240480 days (916 months) after Insulin Glargi...

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ea0073aep292 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

A survey of nutritional issues in type 2 diabetes among patients in khorezm region of uzbekistan

Rakhmetova Malika

Purpose of the studyIn Uzbekistan, more than 80% of patients with type 2 diabetes mellitus have uncompensated diabetes, including those receiving adequate free drug therapy. This is mainly due to the neglect of non-drug measures and unhealthy diets. The purpose of the study was to establish the reasons for patients non-compliance with nutritional rationalization prescriptions, on the example of the Diabetes School at Khorezm Regional Endocrinology ...

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ea0073aep293 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effectiveness of semaglutide in obese patients with type 2 diabetes. a six-month clinical experience

Andrea Fernández Valero , José Ignacio Martínez Montoro , Ana María Gómez Pérez , Damas-Fuentes Miguel , Francisco José Tinahones Madueño

IntroductionSemaglutide is a glucagon-like peptide-1 receptor agonist which has shown important benefits in patients with type 2 diabetes mellitus (T2DM) in randomized clinical trials. Its commercialization in Spain began in May of 2019. The main purpose of this study was to analyze the effectiveness of this drug into routine clinical practice in patients with T2DM with a body-mass index above 30 kg/m2.Matherial and meth...

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ea0073aep294 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD

Mitrovic Bojan , Samardzic Vladimir , Gluvic Zoran , Tomasevic Ratko , Obradovic Milan , Sudar-Milovanovic Emina , Isenovic Esma R.

IntroductionNon-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome (MetS). Hence, it is frequently associated with type 2 diabetes mellitus (T2DM). The low-grade inflammation associated with NAFLD usually explained the changes in serum iron metabolism. This study aims to assess the link between liver steatosis severity and serum iron, ferritin, and transferrin levels.Material and methods<p class="abstext...

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ea0073aep295 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Risk factors for diabetes mellitus in a high-risk population: About 500 cases

Belkacem Samira

IntroductionThe prevalence of diabetes and pre-diabetes is steadily increasing. It affects 3 new cases every 10 seconds and more than 6 million per year. Objective: to determine the risk factors associated with diabetes in an Algiers population not known to be diabetic but at high risk.Methods500 patients aged 40 and over consulting at the level of primary care structures, volunteers but at high risk of diabe...

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ea0073aep296 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Newly diagnosed diabetes in pregnancy among bulgarian pregnant women - national screening in 2019

Trifonova Boyana , Anna-Maria Borissova , Dakovska Lilia , Michaylova Eugenia , Vukov Mircho

According to the FIGO (2015) and later WHO (2019) classifications, hyperglycaemia detected for the first time during pregnancy may be associated with Diabetes In Pregnancy (DIP) or Gestational Diabetes mellitus (GDM).AimTo specify the frequency and type of newly diagnosed diabetes during pregnancy in the Bulgarian population of women.MaterialWe studied 547 pregnant women with a mean age...

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ea0073aep297 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effect of yog nidra on the self-estimated levels of stress and epworth sleep score in t2dm patient.

Saboo Bharat , Saboo Shweta , Sharma Hemant

IntroductionStress and anxiety have become major killers in our developed and devloping countries both. Literature has shown reluction in stress results in better owerall well being. lack of sleep is also a contibutor to stress.In T2DM patients this becomes even more important as the have higher oxidative stress, Yoga Nidra is already prescribed by scholars in several countries because of its potential to activate the parasympathetic nervous system and p...

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ea0073aep298 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

ABSTRACT WITHDRAWN...

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ea0073aep299 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Microbiota disorders in type 2 diabetes and obese patients

Larissa Zvenigorodskaya , Mikhail Shinkin , Akopova Anna , Silvestrova Svetlana

AimTo assess the effect of Zakofalk in complex therapy in patients with type 2 diabetes and obesity.Materials and methodsWe examined 68 patients with type 2 diabetes and 28 with obesity (body mass index over 30 kg/m2). The control group consisted of 20 people. The groups were comparable in terms of age, sex, and antihyperglycemic therapy. In addition to a thorough clinical examination of all study ...

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ea0073aep300 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Evaluation of international experience in the management of patients with diabetes mellitus after liver transplantation

Mikhail Shinkin , Larissa Zvenigorodskaya , Akopova Anna , Mkrtumyan Ashot

AimAnalyze a number of foreign sources to assess the risks of developing post-transplant diabetes mellitus (PTSD).Materials and methodsIn total, we analyzed more than 70 sources from Western Europe, East Asia and South Africa. Pancreatic β-cell dysfunction, impaired insulin secretion associated with the use of calcineurin inhibitors and inhibitors of the mammalian target of rapamycin complex 1 (mTORC1), ...

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ea0073aep301 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Nutritional status of Tunisian women followed for gestational diabetes

Salem Amal , Ali Zohra Haj , Bargaoui zeineb , Htira Yosra , Mami Faika Ben

IntroductionThe respect of dietetic rules constitutes the cornerstone of the management of gestational diabetes (GD). The aim of our study was to describe the spontaneous food intake in Tunisian women followed for GD.MethodsThis is a descriptive and retrospective study, including 82 patients followed at the gestational diabetes unit of the National Institute of Nutrition. We analyzed: age, pre-conceptional bo...

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ea0073aep302 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The role of diabetes in the clinical presentation and prognosis of bell palsy

Masmoudi Mohamed , Hasnaoui Mehdi , Lahmar Rihab , Lazid Sara , Khalifa Mighri

Objectiveto analyze the clinical presentation and prognosis of Bells palsy in diabetic patients.Materiel and methodsThis retrospective study included 76 diabetic patients with Bell s palsy in the ENT department of Tahar Sfar Mahdia; Tunisia from January 1988 to December 2018. The system of House-Brackmann was used for assessing the severity of nerve damage.Results<p clas...

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ea0073aep303 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Poor glycemic control in type 2 diabetes: From eating behavior to therapeutic inertia

Draoui Najat , Tahri Abir , Assarrar Imane , Rouf Siham , Latrech Hanane

IntroductionAdherence to therapy is a common problem, predominating mainly in patients with chronic diseases like diabetes, and it is often associated with inappropriate eating behavior, both of these factors can lead to a poor glycemic control, and of cause a high levels glycated hemoglobin.ObjectivesEvaluate the impact of various parameters (age, gender, duration of diabetes, socio-economic status, polymedi...

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ea0073aep304 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Impact of diabetes mellitus on survival in upper aerodigestive tract squamous cell carcinoma

Masmoudi Mohamed , Hasnaoui Mehdi , Khalifa Mighri , Wadii Thabet , Guizani Rihab

IntroductionAssociation between diabetes mellitus and cancer outcomes has been demonstrated in several cancer sites. Data for upper aerodigestive tract carcinoma are limited. Our aim is to study the impact of diabetes mellitus on survival in upper aerodigestive tract squamous cell carcinoma.Material and methodsA retrospective study of 130 patients treated for upper aerodigestive tract squamous cell carcinoma,...

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ea0073aep305 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Comparing impact of SGLT2 inhibitors and GLP-1 agonists on lipid profile among the patients with diabetes mellitus Type 2. Results of a prospective 18-week observational study

Bostoganashvili Nestan , Kvanchakhadze Rusudan , Mikadze Ketevan , Panchulidze Manoni

BackgroundIn Georgia, significantly huge number of patients with Diabetes Mellitus Type 2 (DMT2) suffer from cardiovascular diseases (CVD) and obesity. Since, dyslipidemia is one of major factors, leading to cardiovascular (CV) mortality, it is crucial to investigate the effects of relatively novel hypoglycemic agents- Sodium Glucose Cotransporter 2 (SGLT2) inhibitors (Dapagliflozin) or Glucagon like peptide 1 (GLP-1) agonists (Liraglutide) on lipid prof...

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ea0073aep306 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Nutritional impact of tobacco in diabetic patients

Elleuch Mouna , Asma Gorchene , Salah Dhoha Ben , Boujelben Khouloud , Moalla Nour , Mnif Fatma , Charfi Nadia , Majdoub Nabila Rekik , Mnif Mouna , Faten Hadj Kacem , Mohamed Abid

BackgroundIts well known that smoking and diabetes are direct causes for serious health problems such as cancer, and atherosclerosis. It is suggested that smoking indirectly leads to atherosclerosis by influencing nutrient intakes as smokers tend to eat more fat and carbohydrates and less mono unsaturated fats and fiber than non-smokers. But no studies assessed the impact of tobacco on nutrition in diabetic patients.Aim<p...

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ea0073aep307 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Characteristics and Prevalence of diagnosed type 1 diabetes among Tunisian adults

Faten Hadj Kacem , Boujelben Khouloud , Twaheerah Allymamod Bibi , Dhouha Ben Salah , Nadia Charfi , Fatma Mnif , Mouna Mnif , Nabila Rekik , Mouna Elleuch , Mohamed Abid

IntroductionDiabetes mellitus is a serious metabolic disease, described by the World Health Organization as a global epidemic. An alarming increase in its prevalence among adults is observed in Tunisia as everywhere else in the world. Because type 2 diabetes preponderates among adults, few epidemiological studies focused on type 1 diabetes (T1D) that occurs during the adulthood. The aim of this study is to determine the prevalence of DT1 among Tunisian a...

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ea0073aep308 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Screening for dyslipidemia in diabetic patients in a town in the Moroccan desert: the town of Es-Smara. Screening for dyslipidemia in diabetic patients in a town in the Moroccan desert: The town of Es-Smara

Ijdda Sara , Rafi Sana , Mghari Ghizlane El , Ansari Nawal El

IntroductionIn diabetes, lipid abnormalities are frequent and pronounced and are an important factor in increased cardiovascular risk, especially in type 2 diabetics, mostly in combination with other risk factors. The aim of this work is to highlight the prevalence of dyslipidemia in a considerable population of diabetics in Es-Smara.Patients and methodsAs part of a multidisciplinary medical caravan carried o...

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ea0073aep309 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Achieving target values for measures for peripheral arterial disease, nephropathy and dyslipidemia in type 2 diabetes- two year assessment

Rohatgi Ragini , Ghodke Sonali , Alfred Daisy

ObjectiveT2DM is a major risk factor of peripheral artery disease, leading to increased morbidity and mortality as well as an accelerated disease course. Microalbuminuria is an indicator for overt nephropathy and early cardiovascular diseaseMethodsWe analysed data from outpatients attending a comprehensive diabetes care centre (n = 202), from 2019 till 2020, who had any of values beyond normal target...

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ea0073aep310 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Vitamin D levels in a cohort of patients with SARS-CoV-2 infection and relationship with disease outcome

Ifigenia Kostoglou Athanasiou , Sofia Nikolakopoulou , Konstantinou Alexandra , Athanassiou Lambros , Spyrantis Alexandros , Olga-Maria Spyropoulou , Mascha Olga , Samaras Charilaos , Bliziotis Ioannis , Athanassiou Panagiotis

Infection with the new SARS-CoV-2 or Covid-19 virus has a variable course. It may run as a mild disease or may cause severe pneumonia necessitating hospitalization. Vitamin D has immunostimulatory action and causes the release of substances necessary for combating an infection. Therefore, the relationship of vitamin D with the SARS-CoV-2 virus is under scientific evaluation. The aim was to measure vitamin D levels in a cohort of patients hospitalized with SARS-CoV-2 infection....

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ea0073aep311 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Impact of the COVID pandemic and lockdown in the glycemic and weight control of patients with type 1 and type 2 diabetes – data from a Portuguese hospital

Franco Sara , Bastos Filipa C. , Ana Gonçalves Ferreira , Barbosa David , Ricardo Capitão , Costa Maria Manuel , Luiz Henrique Vara , Manita Isabel , Cordeiro Maria Carlos , Luísa Raimundo , Portugal Jorge

IntroductionDue to the COVID pandemic, Portugal was forced to start lockdown on March 18 th that lasted until June 1st. Lockdown caused a lot of changes in the daily activities of the Portuguese people, such as eating habits, exercise, time spent at home and stress management. After the lockdown people noticed difficult access to healthcare.ObjectiveOur aim was to evaluate if these changes had an i...

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ea0073aep312 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

An unusual case of hypoglycaemia

Nasir Sadia , Kazmi Syed Kashif , Khan Sidrah , Krishnan Singhan

We report a 77 year old male who presented to the respiratory clinic with episodes of periodic sweating. These episodes were associated nausea. They came on with exercise and always occurred before meals. The resolving factor noted by the patient was food intake and no features suggestive of reactive hypoglycaemia were noted. His past medical history was significant for hypertension, mild bronchiectasis, mild to moderate obstructive sleep apnea requiring CPAP therapy and ische...

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ea0073aep313 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Features of the course of metabolic syndrome in latent autoimmune diabetes in adults

Pashkovska Nataliia , Tsaryk Iryna , Koval Galina , Pankiv Ivan , Piddubna Antonina , Marchuk Yuliya , Abramova Nataliia

IntroductionLatent autoimmune diabetes in adults (LADA) is a specific type of diabetes mellitus (DM), the prevalence of which varies from 4% to 14%. Although LADA combines the pathogenetic and clinical features of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM), the latest recommendations of the American Diabetes Association refer it to T1DM (ADA, 2021). Given that this variant of diabetes is also similar to T2DM, the risk of metabolic syndrome (M...

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ea0073aep314 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Evolution of the parameters of liver function after sleeve gastrectomy

Imene Hedfi , Lajili Olfa , Mahjoub Faten , Amor Nadia Ben , Mizouri Ramla , Olfa Berriche , Henda Jamoussi

IntroductionObesity is an undeniable global health problem that has taken on epidemic proportions in both developed and developing countries. Bariatric surgery offers a promising therapeutic option mostly in the face of frequent failures of dietary management of obesity. Our study aimed to describe the evolution of parameters of liver function after sleeve gastrectomy.MethodsIt was a retrospective study inclu...

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ea0073aep315 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Diabetic peripheral neuropathy: Predictive factors and management

Malki Abdessamad , Loukili Mohamed Aymane , Jamal Anouar , Rouf Siham , Latrech Hanane

IntroductionDiabetic peripheral neuropathy is a common degenerative complication of diabetes. The aim of our work is to focus on the prevalence of this complication in relation to the imbalance of diabetes in type 2 diabetics (T2DM).Materials and methodsThis is a retrospective study, including 202 type 2 diabetic patients hospitalized in an Endocrinology-Diabetology department, over a 6-year time period. All ...

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ea0073aep316 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Chronic diabetic kidney disease, senescenceand cardiovascular disease

Abiega Beatriz Ugalde , Timon Iciar Martin , Moreno-Ruiz Inmaculada , Prats Elena Corchete , Huguet Isabel , Susana Bacete Cebrián , Modamio Javier , Sevillano-Collantes Cristina

Cardiovascular disease (CVD) is more prevalent in patients with chronic kidney disease (CKD) and Diabetes mellitus (DM) than in the general population. Microparticles (MPs) released during cell activation and/or apoptosis could be biomarkers of CVD. These MPs, which show vascular damage, are named according to the injured cell, as endothelial (EMPs) or platelet (PMPs).AimAssess the MPs plasma concentration in diabetic pati...

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ea0073aep317 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Peculiarities of type 2 diabetes in men with androgenic deficiency

Skuridina Daria , Demidova Tatyana

RelevanceAndrogenic deficiency is an important pathogenetic element in the development of metabolic syndrome and cardiovascular diseases in men. It has been proven that in male patients with type 2 diabetes, hypogonadism develops much more often.ObjectiveTo study the features of the course of type 2 diabetes mellitus (T2DM) in men with androgen deficiency. Research objectives: 1. To estimate the incidence of ...

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ea0073aep318 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Influence of depression on glycemic control in patients with typ1 diabetes

Pejicic Snjezana Popovic , Pejicic Nina , Malesevic Gabrijela , Stankovic Valentina Soldat , Dojcinovic Tamara

AimDepression in diabetic patients is related to low quality of life, inadequate abiding by diabetes diet, physical activity and drug therapy.Aim of the stady is determine the presence of depression and its impact on the level of metabolic control of the disease; impact of structured education on the level of knowledge and HbA1c in patient with diabetes type 1 (T1D)MethodsThe study included 38 patients with T...

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ea0073aep319 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Angiotensin-converting enzyme gene (i/d) polymorphism in association with the diabetic nephropathy

Hasan Taner , Trajkovska Ivana , Nedeska Natasha , Ilijevska Cvetanka Volkanovska , Josifovska Slavica

Polymorphisms in the Angiotensin-converting enzyme (ACE) gene have been associated with development of diabetic nephropathy (DN), a major microvascular complication of the type 2 diabetes mellitus (T2DM). Since the genetic predisposition plays an important role in development of DN in patients with T2DM, genetic testing might largely contribute to better assessment of the risk of DN in such patients. The aim of this study is to investigate the association of the ACE gene I/D p...

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ea0073aep320 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Bruns–garland syndrome as the first presentation of type 2 diabetes – a report of two cases from Sri Lanka

Wijewickrama Piyumi , Ambawatte Sathyajith , Gunarathne Kamal , Somasundaram Noel P

IntroductionDiabetes mellitus (DM) is a global health issue. Sri Lanka has the second highest diabetes prevalence at 2079 years in South-East-Asia (1). Diabetic-radiculoplexus-neuropathy is a rare entity causing significant disability, also known as diabetic amyotrophy and Bruns-Garland syndrome, occurring due to immune mediated microvasculitis (2). Although Diabetic-lumbo-sacral-radiculoplexes-neuropathy (DLRPN) is well described, Diabetic-cervica...

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ea0073aep321 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Immune thrombocytopenia presenting with celiac disease and Hashimoto’s Thyroiditis in type 2 diabetes patient: A case report

Khalaf Rahma , Ali Zohra Hadj , Htira Yosra , Mami Faika Ben

IntroductionThe combination of at least three autoimmune diseases in the same patient is defined as multiple autoimmune syndrome. Recent studies demonstrated a higher prevalence of celiac disease in patients with immune thrombocytopenia when compared to the general population. Here we report the occurrence of celiac disease, Hashimotos disease and immune thrombocytopenia in type 2 diabetes patient.Case report<p class="abs...

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ea0073aep322 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

A retrospective analysis of clinical manifestations of patients with acute intermittent porphyria: three case reports and literature review

Li Qingyang , Ren Yi , Yang Jing

BackgroundAcute intermittent porphyria (AIP), a rare autosomal-dominant inherited disorder, caused by pathogenic mutations in the gene encoding porphobilinogen deaminase (PBGD). To explore its clinical characteristics, we investigated three patients with AIP admitted to our hospital.MethodsIn this study, patients successfully diagnosed with AIP and treated at the First Hospital of Shanxi Medical University si...

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ea0073aep323 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Identification of a novel mutation of the abcc8 gene in a greek subject with mody12

Kanti Georgia , Papanastasiou Labrini , Sertedaki Amalia , Glikofridi Spyridoula , Gantenbein Christina Kanaka , Kounadi Theodora

IntroductionMaturity-onset diabetes of the young (MODY) constitutes a group of clinically and genetically heterogeneous monogenic forms of diabetes, characterized by beta-cell dysfunction. It describes an autosomal dominantly inherited disorder, caused by mutations in different genes, characterized by noninsulin-dependent diabetes commonly diagnosed at a young age. Fourteen MODY subtypes have been reported, often misdiagnosed as type 1 or 2 d...

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ea0073aep324 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Diabetes, a harbinger of pancreatic tumor

Mehrzi Amal , Jemel Manel , Madhbouh Meriem , Chatti Hiba , Madhi Wiem , Kammoun Ines

IntroductionPancreatic cancer is one of the cancers of the digestive tract for which the prognosis has not been improved in terms of early diagnosis. Recent diabetes can be indicative of this pathology.ObservationA 56-year-old man with no notable pathological history who has presented for 04 months a deterioration in general condition with weight loss. On clinical examination: BMI: 17 kg/m2. In bio...

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ea0073aep325 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Association of glucocorticoid receptor gene polymorphism A3669G (9β) with lower glucose concentration 2 hours after OGTT in patients during chronic glucocorticoid treatment

Nowak Karolina , Sobalska-Kwapis Marta , Zgliczynski Wojciech , Papierska Lucyna

Background23% of the general population is chronically treated with glucocorticoids (GCs). Modification of the structure and/or function of the glucocorticoid receptor (GR) due to its polymorphisms may result in increased (GC S bclI, N363S) or decreased (GC I A3669G, ER22/23EK) sensitivity to GCs. To date, whether such modulation of cells response to GCs can be associated with presence or absence of the side effect...

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ea0073aep326 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

A case of hypertriglyceridemia after the use of tamoxifen

Gunay Yasemin Emur , Tufekci Damla , Ahmet suat Demır , Bilginer Muhammet Cuneyt , Coskun Hulya , Nuhoglu Irfan , Ucuncu Ozge , Kocak Mustafa

IntroductionTamoxifen is a selective estrogen receptor modulator used in the treatment of estrogen/progesterone receptor-positive breast cancer. Due to the increased frequency of breast cancer in the premenopausal period, the use of tamoxifen is quite common in patients with hormone receptor positivity. Although it is a commonly-used drug, the number of cases with elevated triglyceride levels is very few. Here, we present a case with severe hypertriglyce...

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ea0073aep327 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The impact of violated production of vascular endothelial growth factor expression on thyroid hormones metabolism in obese patients

Abramova Nataliia , Pashkovska Nataliia , Marchuk Yuliya , Pankiv Ivan , Piddubna Antonina , Koval Galina , Tsaryk Iryna

IntroductionObesity is an important medical and social problem of our time, because its prevalence is growing rapidly and affects about 30% of the adult population of the planet. Obesity is characterized by an increase in the expression of cytokines that cause endothelial damage. It is known that prohormone thyroxine (T4) is converted into 5 times more active triiodothyronine (T3) in peripheral organs (such as live...

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ea0073aep328 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Non alcoholic steatohepatitis related cirrhosis and hepatocellulair carcinoma: A ten years rerospective study

Soumaya Mrabet , Raida Harbi , Akkari Imen , Elhem Ben Jazia

IntroductionCurrently, the incidence of metabolic steatopathies is clearly increasing. Unlike simple fatty liver disease, non-alcoholic steatohepatitis (NASH) can progress to cirrhosis and hepatocellular carcinoma (HCC). The aim of our study was to determine the factors associated with these complications in patients with NASH.MethodsThis is a retrospective study including all cirrhotic patients followed betw...

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ea0073aep329 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The role of obesity management in the reversal of type 2 diabetes mellitus

Omer Tahir

The prevalence of Type 2 Diabetes Mellitus (T2DM) is drastically rising globally. It is projected to rise to close to 600 million in 2 decades. This rise parallels the increased prevalence of obesity which is estimated to rise to over 1 billion obese individuals by the year 2025. The association between the Body Mass Index (BMI) and type 2 Diabetes is well recognised. Raised BMI is a major predictor of the risk of T2DM. T2DM is associated with multiple complications and it wie...

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ea0073aep330 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Study on oxidative stress parameters in obesity associated insulin resistance and diabetes mellitus

Saatov Talat , Irgasheva Sanobarkhon , Ibragimov Zafar , Ibragimova Elvira , Ishanhodjaev Tokhir , Zainutdinov Bakhodyr , Mustafakulov Mukhammadjon , Alimov Timur , Maksutova Nigora , Shamansurova Zulaykho

Obesity of varying severities can be seen in the vast majority of patients with type 2 diabetes mellitus (DM2). Oxidative stress is considered as a key pathogenetic link in the formation of metabolic disorders in obesity. The work was initiated to assess intensity of oxidative stress in obese patients with DM2.Materials and methodsThe patients were divided into 3 groups. Patients with DM2 and BMI > 30 kg/m2 were incl...

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ea0073aep331 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Do metabolic syndrome and diabetes affect skin autofluorescence in patients with morbid obesity?

Apaydin Tugce , Yavuz Dilek Gogas

PurposeObesity, diabetes mellitus, and metabolic syndrome (MetS) have been known to be associated with increased skin autofluorescence (SAF). In patients with MetS, higher SAF measurements were found to be associated with an increased number of the components of MetS. In this cross-sectional study, we aimed to evaluate the association of MetS and its components with skin autofluorescence in severely obese patients and to examine whether diabetes or...

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ea0073aep332 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Prevalence of obesity and its association with metabolic diseases in women from low-and-middle income countries (LMICs): A systematic review and meta-analysis

Rocha Thais , Melson Eka , Zamora Javier , Borja M. Fernandez-Felix , Soby Soha , Betran Ana Pilar , Arlt Wiebke , Thangaratinam Shakila

IntroductionObesity is a global health challenge, with more than 50% of the world´s obese population residing in LMICs. Although adiposity is a well-known major risk factor for noncommunicable diseases (NCDs) such as hypertension, and diabetes mellitus, the delivery of effective NCDs interventions is still a challenge to health systems. About 85% of the NCDs premature deaths occur in LMICs. Obesity is more prevalent in women than men, however the bu...

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ea0073aep333 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Adherence to the mediterranean diet and metabolic syndrome: Potential relationship in patients candidates for bariatric surgery

Sara León Utrero , Mª del Carmen Andreo López , Torres Enrique Redondo , Mª del Carmen Serrano Laguna , Mª Luisa Fernández Soto

ObjectiveTo study the possible relationship between adherence to the Mediterranean diet and the metabolic syndrome. Material and methods: Retrospective observational study of patients evaluated in a prebariatric surgery consultation between November 2017 and November 2019, who were given a questionnaire of adherence to a Mediterranean diet. Anthropometric and analytical parameters related to the metabolic syn...

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ea0073aep334 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Antipsychotic induced obesity in schizophrenia and GLP-1 analog treatment? – A case-report

Iva Jakubíková , Martin Haluzík MD DSc

IntroductionSchizophrenia is one of the seven most disabling diseases according to World Health Organization. The most potent antipsychotic drugs clozapine and olanzapine are associated with excessive weight gain. Premature deaths in schizophrenia and shorter life expectancy are mainly caused by obesity-related cardiovascular diseases. Obesity itself is associated with brain deterioration, cognitive decline and overall worse quality of life. GLP-1 recept...

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ea0073aep335 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Trends in dietary food groups and DASH score among adults: A longitudinal study from tehran lipid and glucose study, 2006–2017

Aghayan Maryam , Hossainpour Somayeh , mirmiran Parvin

BackgroundTo examine the secular trends of dietary food groups and diet quality among adults, overall and by sex, education, and occupation status.MethodsThis study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS). Demographic and anthropometric measurements were gathered using standard questionnaires. In terms of socioeconomic information, participants were divided into two gro...

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ea0073aep336 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

A case of post-partum diabetic ketoacidosis in a patient with gestational diabetes mellitus

Jadoon Nauman

BackgroundThere is ample data linking GDM to risk of type 2 diabetes mellitus postpartum, however, development of type 1 diabetes mellitus and presentation with DKA is rare especially few weeks postpartum.CaseA 28 year old female 4 month postpartum was admitted to hospital with rapid weight loss and osmotic symptoms. She did not have any past medical history of note, with history of T2DM in both mother and fa...

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ea0073aep337 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

A challenging presentation of Catamenial DKA

Ahmed Nabeel

A 34-year-old T1DM nurse was admitted with a history of recurrent episodes of DKA. In the current admission at our hospital, on detailed history she reported of getting DKA almost every month when her menses would start. She would be following the sick day rules of DKA but it wouldnt help prevent her going into DKA. No other precipitating factors were found. She was diagnosed as a case of Catamenial DKA and was started on OCPs to see how what effect it would have o...

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ea0073aep338 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Management of cervicofacial odontogenic cellulitis in diabetics

Masmoudi Mohamed , Hasnaoui Mehdi , Sara Lazid , Lahmar Rihab , Khalifa Mighri

ObjectiveTo summarize the characteristics and treatment experience of cervicofacial odontogenic cellulitis in diabetic patients and to provide clinical basis for the diagnosis and treatment.Material and methodRetrospectively analysed 50 cases of cervicofacial cellulitis in diabetics in the ENT department of Taher Sfar Mahdia, Tunisia from from january 2015 to december 2018.Results<p...

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ea0073aep339 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Predictors of masked hypertension in type 2 diabetics

Wajdi Safi , Faten Hadj Kacem , Charfi Hana , Dorra Ghorbel , Mouna Elleuch , Khouloud Boujelben , Faten Triki , Fatma Mnif , Nadia Charfi , Mouna Mnif Feki , Nabila Rekik , Samir Kammoun , Mohamed Abid

IntroductionMasked arterial hypertension (HTAM) is a relatively recently described entity which gives patients with it the same cardiovascular risk as permanent hypertension. In this context, we report a prospective study including 53 patients in order to determine the prevalence and predictive factors of HTAM in diabetics.MethodsDescriptive prospective study of 53 patients treated in the endocrinology Diabet...

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ea0073aep340 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Management of carpal tunnel syndrome in diabetic patients

Elarem Soumaya , Salah Aymen Haj , Haddada Ikram , Kerkeni Hajer , Said Wafa , Sghir Mouna , Kessomtini Wassia

IntroductionCarpal tunnel syndrome (CTS) is the most common compressive neuropathy in upper limb. Although most causes are idiopathic, CTS may be associated with some systemic conditions such as diabetes mellitus (DM). The aim of this study was to describe conservative procedures used in physical medicine and rehabilitation in the management of CTS.Patients and methodsWe carried out a descriptive retrospectiv...

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ea0073aep341 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Prevention of cardiovascular risk in the elderly with diabetes

Abir Tlili , Lassoued Najoua , Senda Rebai , Wafa Alaya , Baha Zantour , Habib Sfar Mohamed

IntroductionCardiovascular disease is the leading cause of death ahead of infectious diseases and cancers. The frequency of morbidity and mortality associated with cardiovascular diseases increases in the elderly and their management becomes more difficult. Hence an early and adequate management of cardiovascular risk factors is needed. The objective of this work was to determine the cardiovascular risk factors in elderly diabetics and to assess the qual...

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ea0073aep342 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The effects of COVID-19 pandemic lockdown on metabolic control of people with diabetes

Adile Begum Bahcecioglu Mutlu , Sahin Mustafa , Asena Gökçay Canpolat , Corapcioglu Demet

AimsDuring April and May 2020 in Turkey, changing priorities in the health system and some restrictions on daily life in order to prevent the spread of SARS-CoV-2 infection may worsen metabolic control of people with diabetes. We aimed to investigate whether glycemic dysregulation or disturbance of lipid metabolism occur in people with diabetes during the lockdown period.MethodsThis retrospective study includ...

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ea0073aep343 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The effect of Covid-19 pandemic lockdown on the blood glucose regulation of diabetic patients; one center experience

Gunay Yasemin Emur , Coskun Hulya , Unal Egemen , Tufekci Damla , Demir Ahmet Suat , Bilginer Muhammet Cuneyt , Ucuncu Ozge , Nuhoglu Irfan , Kocak Mustafa

AimThe COVID-19 pandemic has affected the whole world, reducing hospital admissions of patients with chronic diseases. This study aims to evaluate the effects of difficulties experienced by diabetic patients in diabetes management on blood glucose regulation during the COVID-19 pandemic lockdown.MethodsThis study included 93 diabetic patients followed up in Endocrinology and Metabolic Diseases Clinic of Karad...

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ea0073aep344 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Hypoglycemia in non-diabetic patients

Najoua Messaoudi , Bouichrat Nisrine , Derkaoui Nada , Karrou Marouan , Imane Rami , Rouf Siham , Latrech Hanane

Keywords: Hypoglycemia- non-diabetic patientsIntroductionHypoglycemia in non-diabetic patients is a rare entity, diagnosed by the presence of Whipples triad (plasma glucose concentration less than 50 mg/dl, neuroglycopenic-symptoms, and resolution of symptoms after the correction of hypoglycemia). It may be secondary to several etiologies, including tumors that may be malignant. Prolonged supervised fasting is frequently used...

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ea0073aep345 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The functional status of the thyroid gland in pregnant women with gestational diabetes mellitus

Ushanova Fatima , Demidova Tatyana

Background and aimsGestational diabetes mellitus (GDM) is a disease manifested by hyperglycemia, first diagnosed during pregnancy, which usually resolves after delivery. In GDM, there is a risk of adverse effects in both a mother and a fetus. Thyroid hormones (TG) play a huge role in the proper development of the child. Given the high prevalence of thyroid pathology and disorders of carbohydrate metabolism during pregnancy, the study of the relationship ...

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ea0073aep346 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Use and effectiveness of dapagliflozin in type 1 diabetes: Clinical experience data of six months

José Ignacio Martínez Montoro , Andrea Fernández Valero , Fuentes Miguel Damas , José Luis Pinzón Martín , Tinahones Francisco J

IntroductionSodium-glucose cotransporter-2 inhibitors (SGLT2i) are a new class of oral antidiabetic drugs used for the treatment of type 2 diabetes mellitus. Recently, the SGLT2i dapagliflozin was approved for use in type 1 diabetes (T1DM) as an add-on to insulin therapy.Material and methodsWe conducted a retrospective observational study which included demographic and clinical-analytical data from 16 patient...

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ea0073aep347 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Growth factors in trophic disorders in diabetics

Pangui Henricia Laurinda , Amal Mjabber , Haraj Nassim Essabah , Aziz Siham El , Chadli Asmaa

IntroductionEpidermal growth factors accelerate healing in lesions of trophic disorders.MethodsThis is a prospective study carried out between February and June 2019 in the endocrinology and metabolic diseases department, involving 6 patients admitted for diabetic foot progressing for more than 3 months without healing after conventional treatment. Having received the injections of growth factors of the EGF t...

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ea0073aep348 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The impact of functional insulin therapy on the psychological aspect of type 1 diabetics

Bammou Sanaa , Abderrahmane Ait Yahya , Sana Rafi , Ghizlane El Mghari , Nawal El Ansari

IntroductionFunctional insulin therapy is an educational method that is part of a strategy to intensify type 1 diabetes in order to optimize the balance of diabetes while improving the psychological aspect of the patient. The aim of this study is to assess the impact of functional insulin therapy on the psychological aspect of type 1 diabetics.Patients and methodThis is a retrospective and analytical descript...

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ea0073aep349 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Implementation of flash glucose monitoring system in a regional hospital in the province of Cordoba

Ana Barrera Martín , Mª del Carmen Serrano Laguna , Rocío Domínguez Rabadán , María Ángeles Gálvez Moreno

IntroductionThe development of flash glucose monitoring system (FGM) has led to a change in the paradigm of diabetes control, beyond the evaluation of glycosylated hemoglobin (HbA1c). FGM allows to improve control of type 1 diabetes mellitus (T1DM) and the quality of life of patients.ObjectiveDescribe the baseline characteristics of patients with T1DM in a regional hospital in the southern area of the provinc...

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ea0073aep350 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Dietary beliefs and behavior of pregnant women with diabetes

Maryem Bouab , Sabah Moukhlis , Ouafidi Btissam , Miski Fatiha El , Lamrissi Amine , Fichtali Karima , Bouhiya Said

IntroductionPregnant women with diabetes are prone to overeating and decreased physical activity, both sources of glycemic disorder. The objective of our study is to evaluate these dietary beliefs in order to improve the management of diabetes.Materials and methodsProspective observational study, including 100 patients with diabetic pregnancy followed in the department of gynecology and obstetrics of the ibn ...

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ea0073aep351 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Seasonal changes of 25(OH) vitamin D among elderly patients

Nowak Justyna , Jabczyk Marzena , Barbara Zubelewicz-Szkodzinska

IntroductionVitamin D plays an important role in human physiology. It is synthesis mainly by the skin during sun exposure. Elderly population are at risk to develop vitamin D deficiency caused by many factors (reduced sunlight exposure, impaired skin synthesis and hydroxylation in the liver and kidney as well as decreased dietary intake and impaired intestinal absorption).AimThe purpose of the study was to as...

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ea0073aep352 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Bullosis diabeticorum

Khelifi Dayssem , Bacha Takwa , Jones Meriem , Litaiem Noureddine , Zeglaoui Faten

IntroductionSkin damage is common in diabetes. They can be classified into three groups: dermatoses associated with diabetes, acute and chronic skin complications of diabetes and dermatoses associated with antidiabetic treatments. Bullosis in diabetics, also called Bullosis diabeticorum, is one of the cutaneous complications of diabetes. It is a rare bullous dermatosis particular by its exclusive occurrence in diabetics.Observation...

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ea0073aep353 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Screening for obstructive sleep apnoea in type 2 diabetes subjects using STOP-BANG questionnaire

Talwar Vipan , Talwar Gourav

IntroductionThe association between Obstructive sleep apnoea (OSA) and type 2 diabetes mellitus (T2DM) is well known and this combination imposes a higher risk of complications in the affected indvidual. Polysomnography which is a gold standard for diagnosing OSA is not universally available, so many of the patients with OSA remain undiagnosed. A questionnaire-based OSA screening for risk stratification can help early detection of OSA in T2DM.<p clas...

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ea0073aep354 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Predictors of the development of androgen deficiency in men with type 2 diabetes mellitus

Vaschenko Elena

The aim of the study is the search of predictors of the development of androgen deficiency in men with 1 diabetes mellitus type 2. The study included 243 men with type 2 diabetes mellitus aged 3555 years. The median age of men was 39.00 [30.00; 45.00] years, the median duration of diabetes mellitus type 2 was 12.00 [7.00; 22.00] years. As a result of the research, it was found that an increase in the patients age significantly increased the risk of developing andro...

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ea0073aep355 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Mucormycosis of the ENT sphere in diabetic subjects: About 4 observations

Bellakhdhar Mouna , Belaid Takwa , Monia Ghammam , A Ben Abdelkarim , A Yaakoub , Abir Mahrezi , Wassim kermani , Koussay El Euch , A Fathallah , Mohamed Abdelkafi

IntroductionMucormycosis is a rare and often fatal fungal infection which is caused by a group of molds called mucormycetes.It usually occurs in immunocompromised subjects and especially diabetics. The aim of our work is to specify the epidemiological, clinical and therapeutic characteristics of ENT mucormycosis in diabetic subjects.Material and methodsA retrospective study included 4 diabetic patients with E...

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ea0073aep356 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Obesity before and during pregnancy-a powerful risk factor for hyperglycemia in pregnant Bulgarian women

Trifonova Boyana

The epidemic of obesity, as well as the reduced physical activity are a complex of reasons for the increase in the frequency of Glucose tolerance disorders. The aim was to analyze the frequency and role of Obesity/Overweight for the development of Hyperglycemia in the Bulgarian population of pregnant women.MaterialWe screened 547 pregnant women, mean age 30.49 ± 5.12 years, divided into two groups: with Hyperglycemia (n</e...

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ea0073aep357 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Isolation of nerve growth factor in blood specimens from patients with type 1 diabetes mellitus

Saatov Talat , Artykbaeva Gulnora , Yalalova Ilmira , Mamadjanov Akhmadjon

Physiological role of nerve growth factor (NGF) was characterized for the sensory and vegetative nervous systems, as well as for the central, endocrine and immune systems. The growth simulator and a cytokine, NGF is known to be involved in the metabolism of various pathological conditions. Recent clinical and academic studies among patients with diabetes mellitus, insulin resistance and Alzheimers disease have brought to light previously unreported cell and pathological ...

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ea0073aep358 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Impact of diabetes on liver fibrosis in chronic hepatitis C

Soumaya Mrabet , Raida Harbi , Akkari Imen , Elhem Ben Jazia

IntroductionChronic hepatitis C (CHC) is associated with an increased incidence of insulin resistance and diabetes mellitus. Obesity and insulin resistance are associated with faster progression of fibrosis in these patients. The aim of our study was to assess the impact of diabetes on the severity of hepatic fibrosis in patients followed for CHC.MethodsThis is a retrospective study conducted between January ...

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ea0073aep359 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Type 2 diabetes in young people About 30 cases preliminary results

Ornella Marline Yvonne Dinghat , Haraj Nassim Essabah , Aziz Siham El , Chadli Asmaa

IntroductionType 2 diabetes has long been considered a disease of overweight adults. However, its incidence is increasing rapidly in children and adolescents along with that of overweight and obesity. The aim of this study was to assess the prevalence and clinical profile of type 2 diabetes in young subjects.Materials and methodsDescriptive prospective study from January 2019 to August 2020 including 30 diabe...

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ea0073aep360 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Dunnigan syndrome in Central South Africa: A case report

Thabiso Rafaki Petrus Mofokeng , Poswa Nontsikelelo

IntroductionFamilial partial lipodystrophy type 2 is caused by several pathogenic variants of lamin LMN gene. Males and females are equally affected by the autosomal recessive condition which manifests before age 2. They gradually loose fat in the upper and lower extremities as well as the gluteal area.CaseWe present a 31 year old female athlete who presented with oligomenorrhoea, diabetes mellitus, and sever...

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ea0073aep361 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Syndromic mitochondrial diabetes: About three Tunisian families

Safi Wajdi , Tabbebi Mouna , Kacem Faten Hadj , Charfi Hana , Chiraz Zayani2 , Salah Dhouha Ben , Feki Mouna Mnif , Fakhfakh Faiza , Abid Mohamed

IntroductionMitochondrial diabetes (DM) is characterized by a broad spectrum of phenotypic and genotypic involvement. Among 86 patients with DM, we chose to study the peculiarities of syndromic DM diagnosed in three families in order to be able to establish a correlation between this diversity of phenotypic expression and the biomolecular substratum of the mitochondrial genome.ResultsThese are four patients (...

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ea0073aep362 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Clinical features of patients with diabetic ketoacidosis and acute pancreatitis

Salah Dhouha Ben , Zargni Asma , Elleuch Mouna , Gherissi Wiem , Mnif Fatma , Charfi Nedia , Mnif Mouna , Majdoub Nabila Rekik , Faten Hadj Kacem , Mohamed Abid

IntroductionAcute pancreatitis (AP) is the most common affection of the pancreas, it often leads to glycemic disorders. On the other hand, diabetic ketoacidosis (DKA) is associated with nonspecific increase in serum amylase levels. The aim of this study was to evaluate the clinical characteristics of acute AP concomitant with DKA.MethodsWe conducted a retrospective and descriptive analysis of clinical records...

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ea0073aep363 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Solid pseudopapillarytumor of the pancreas: Report of a special case

Kacem Faten Haj , Salah Ameni , Elmokhtar Sidina Med , Elleuch Mouna , Salah Dhouha Ben , Mnif Fatma , Mnif Mouna , Rekik Nabila , Charfi Nadia , Abid Mohamed

IntroductionSolid pseudopapillary tumors (SPT) of the pancreas area rare exocrine pancreatic tumor behaving in a low-grade fashion, with limited local invasion risk and a rare metastatic evolution. They mainly affect young women. Their etiopathogenesis remains uncertain. We report the case of a 15-year-old boy, having congenital anomalies, who presented a solid and pseudopapillarytumour of the pancreas.Case report<p class="abst...

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ea0073aep364 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Characteristics of the metabolic syndrome in the elderly with diabetes

Abir Tlili , Lassoued Najoua , Senda Rebai , Wafa Alaya , Baha Zantour , Habib Sfar Mohamed

IntroductionThe metabolic syndrome (MS) presents a major public health problem, especially in elderly diabetics. The objective of this study is to assess the frequency and characteristics of MS in elderly diabetics.Patients and methodsRetrospective study of 94 diabetic subjects over the age of 65 years who were hospitalized in the endocrinology department of Mahdia or followed at the outpatient clinic between...

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ea0073aep365 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Diabetic retinopathy: prevalence and risk factors in a type 2 diabetic population

Safi Eya , Htira Yosra , Dridi Manel , Achwak Mehrez , Hakiri Ghofrane , Sabrine Zribi , Ali Zohra Hadj , Mami Feika Ben

IntroductionOne of the major complications of diabetes that can lead to blindness is diabetic retinopathy. The objective of our work is to determine the prevalence of this complication in a type 2 diabetic population as well as its various risk factors.Methods:This is a retrospective study including 100 type 2 diabetic patients followed up in the C department of nutrition and diabetology at the Na...

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ea0073aep366 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Diabetes-related knowledge among type 2 diabetic patients in Sfax, south Tunisia

Mejdoub Yosra , Ayedi Kawthar , Salah Dhoha Ben , Elleuch Mouna , Maamri Hanen , Dammak Jamel , Jdidi Jihen , Mohamed Abid

IntroductionType 2 diabetes mellitus is a major non communicable disease which needs continuous and improved interventions. Knowledge assessment studies are useful for providing baselines for healthcare policies and educational programs.Aim of this studyTo evaluate diabetes-related knowledge among type 2 diabetes patients.MethodsA cross sectional study was conduct...

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ea0073aep367 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Quality improvement project on pilot joint diabetes-renal clinics in a district general hospital in United Kingdom

Subbiah Kasi , Mahmood Aizzah , Perumal Samundeeshwari , Chitalia Nihil , Mohandas Cynthia

Diabetes is the leading cause of end stage renal failure. So, identifying patients at risk and intensifying management of blood pressure, lipids and glycaemic control can reduce and delay progression to organ replacement therapy. The aim of our study was to determine whether our pilot 3 monthly joint diabetes-renal clinics set up in April 2018 was able to achieve targets outlined by national guidelines and whether patient satisfaction and improved outcomes could lead to furthe...

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ea0073aep368 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Type 1 diabetes and Klinfelter syndrome: A case report

Rihab Ajili , Hasni Yosra , Asma Ben Abdelkarim , Ghada Saad , Maha Kacem , Amal Maaroufi , Molka Chaieb , Koussay Ach

IntroductionKlinfelter syndrome (SK) is the most common sex chromosome disorder. Affected males carry an additional × chromosome, which results in male hypogonadism, obesity and an insulin resistance field explaining the frequent association of KS and type 2 diabetes. However, cases of type 1 diabetes (T1D) in KS are rarely reported in the literature. We report a case.ObservationThis is a 31-year-old pat...

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ea0073aep369 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Seasonal variation of diagnosis of Type 1 diabetes mellitus: A real phenomenon-Preliminary results

Yakhlef Salma Ben , Najoua Messaoudi , Derkaoui Nada , Rouf Siham , Latrech Hanane

IntroductionDiabetes is a growing health concern, considered as a worldwilde multifactorial public health challenge especially in developping countries. The concept of seasonality in T1DM diagnosis, has been suggested by different studies, implying the existence of several environmental factors as triggers and potentiators of β-cell destruction. The purpose of this study is to elucidate epidemiological profile and the seasonal variation of type 1 di...

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ea0073aep370 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The peculiarities of diabetes in the elderly

Jamal Anouar , Loukili Mohamed Aymane , Malki Abdessamad , Rouf Siham , Latrech Hanane

IntroductionThe number of elderly diabetics continues to increase and represent a large and great fraction of the elderly and diabetics. Thus the objective of our study is to show the particularities in this population.Materials and MethodsThis is a retrospective study included 107 type 2 diabetic patients aged 65 years and older hospitalized in an Endocrinology-Diabetology and Nutrition department of Mohamd ...

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ea0073aep371 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Epidemiological aspects and therapeutic conduct necrosant fungal ear infections: about 20 cases

Ghammem Monia , Chouchane Lobna , Bellakhdher Mouna , Lahmar Rihab , Kermani Wassim , Abdelkafi Mohamed

AimsNecrotizing external otitis (NEO) is osteomyelitis of the base of the skull. Previously Pseudomonas Aeruginosa was incriminated in 90% of cases. However, fungal NEO have been emerging in recent years. It is a pathology that occurs primarily in immunocompromised terrain such as diabetic and may affect the patients functional and vital prognosis.Materials and methodsA retrospective study of 20 cases o...

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ea0073aep372 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Atypical presentation of Type 1 diabetes mellitus

Niven Mark , Kafri Esther , Nissim Elizabeth , Dubin Ina

IntroductionDiabetic ketoacidosis (DKA) is associated with Type 1 diabetes mellitus (T1DM), whilst hyperglycemic hyperosmolar state (HHS) with Type 2 (T2DM). HHS has been well described as a presentation of T1DM in children, but not in adults. We present present a case of T1DM presenting in a young adult as HHS, with severe hyperglycemia but without acidosis.Case reportA 21 year old male presented with a 4 5 ...

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ea0073aep373 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Diabetic ketoacidosis precipitated by COVID-19 in patient without respiratory symptoms: 2 case reports

Lassoued Najoua , Rihab Ajili , Senda Rebai , Jihen Chelli , Baha Zantour , Habib Sfar Mohamed

IntroductionDiabetes mellitus (DM) is one of the risk factors associated with severe illness in Coronavirus disease 2019 (COVID-19) leading to increased hospital admissions and mortality. COVID-19 can precipitate hyperglycemic emergencies like diabetic ketoacidosis (DKA) in patients with DM. We report 2 cases of diabetic ketoacidosis (DKA) secondary to COVID-19 with an atypical clinical picture mainly made up of neurological disorders without respiratory...

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ea0073aep374 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Wolfram syndrome: A diagnostic challenge

Khelifi Dayssem , Debbabi Wided , Kharrat Issam , Samet Slim

IntroductionWolfram syndrome (also known as DIDMOAD syndrome) is a rare, genetic, endocrine disorder characterized by the early onset of diabetes mellitus and optic atrophy. It is frequently associated with diabetes insipidus, deafness and neurological signs.ObservationA 26-year-old woman was burn out of a consanguineous marriage. Diabetes mellitus was revealed at the age of 6 by ketoacidosis, treated from th...

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ea0073aep375 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Iatrogenic hypercalcemia and depression. A case report

Kermaj Marjeta , Elezi Edlira , Xhindi Marsela , Ylli Agron

IntroductionCalcium is an important metabolite. Abnormal blood calcium levels can affect brain function resulting in clinical signs. Iatrogenic hypercalcemia is a disorder rarely described in literature and there are few reported cases of association with neuropsychiatric manifestations. Psychiatric symptoms and abnormal physical symptoms are usually observed with a serum calcium level above 12 mg/dl. Our case report findings suggest the importance of co...

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ea0073aep376 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Pancreatic cancer masquerading as uncontrolled diabetes

Phyo Nyein Ei , Moodley Praneshan , Platt Geraldine Quintero

We describe the case of a 77 year old male admitted with acute confusion. He had a background of Type 2 Diabetes Mellitus, alcohol excess, hypertension, and was a heavy smoker. A venous blood gas showed a high anion gap metabolic acidosis (pH 7.327, a modestly elevated lactate at 1.3), a glucose level of > 27.8 mmol/l, with a capillary ketone level of 5.0 mmol/l. His calculated serum osmolality was 276 mmol/kg, although account was not taken of the possibility of concomita...

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ea0073aep377 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The estimation of comorbid endocrine and metabolic disorders based on CIRS score in emergency workers of the Chernobyl accident having cardiovascular diseases

Belyi David , Nastina Olena , Sydorenko Gennadyi , Gabulavichene Zhanna , Kursina Nataly , Bilaya Victoriya , Bazyka Olexander , Kovaliov Olexander

Objective was to analyze the place of endocrine and metabolic disorders among other comorbid diseases in the Chernobyl accident emergency workers (EW) who had cardiovascular diseases as main pathology.Materials and methodsThe health state was analyzed in 420 male EW, who worked at the Chernobyl NPP at 19861987 yrs, and 188 males not exposed to ionizing radiation (the control group, CG). Patients of both groups had a hospital ...

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ea0073aep378 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Prescription of Statins in the elderly with diabetes

Abir Tlili , Lassoued Najoua , Rihab Ajili , Wafa Alaya , Baha Zantour , Habib Sfar Mohamed

IntroductionThe prevalence of cardiovascular disease in the elderly is very important. The prevention of cardiovascular risk is essential in order to avoid the morbidity and mortality associated with these diseases. The objective of this study was therefore to assess the frequency of prescription of statins in elderly with diabetes and to analyze the benefit risk ratio of this prescription.Patients and methods<p class="abstext"...

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