ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)
Chronic diabetic kidney disease, senescenceand cardiovascular disease
Beatriz Ugalde Abiega 1 , Iciar Martin Timon 1 , Inmaculada Moreno-Ruiz 1 , Elena Corchete Prats 2 , Isabel Huguet 1 , Susana Bacete Cebrián 1 , Javier Modamio 1 & Cristina Sevillano-Collantes 1
1Hospital Infanta Leonor, Endocrinology, Madrid, Spain; 2Hospital Infanta Leonor, Nephrology, Madrid, Spain
Cardiovascular disease (CVD) is more prevalent in patients with chronic kidney disease (CKD) and Diabetes mellitus (DM) than in the general population. Microparticles (MPs) released during cell activation and/or apoptosis could be biomarkers of CVD. These MPs, which show vascular damage, are named according to the injured cell, as endothelial (EMPs) or platelet (PMPs).
Aim
Assess the MPs plasma concentration in diabetic patients with or without nephropathy, and evaluate its correlation with the occurrence of CVD.
Patients and methods
A prospective, observational, transversal study in 46 diabetic patients from Infanta Leonor University Hospital. Total MPs, endothelial and platelet, were measured in all cases. The Chi-square test was used to compare qualitative variables, and a linear regression analysis with the MPs as a dependent variable. A P < 0.05 was considered significant.
Results
Out of the 46 patients, 27 (58.7%) were men, and 23 (50%) were on hemodialysis (HD). The average age was 64.9 (11.7) years old, patients on HD being older (P < 0.01). They also had a higher frequency of atrial fibrillation (P < 0.035), retinopathy, neuropathy, heart failure, peripheral artery disease and high blood pressure (HBP) (P < 0.01for all), than patients with normal glomerular filtration rate. They showed, as well, a higher number of total MPs (P < 0.01) and endothelial MPs (P < 0.01), with no difference of PMPs. The linear regression analysis to establish if the difference was a consequence of age or HD, showed that only HD was a determining factor for total MPs, but not for EMPs.
| Diabetic patients on HD (n = 23) | Diabetic patients with normal RR(n = 20) | Total DS o% | P | |
| Sex ♂ | 16(61.5%) | 11(55%) | 27(58.7%) | ns |
| Atrial fibrillation | 5(21%) | 0 | 5(11.6%) | 0.035 |
| Ischemic cardiopathology | 5(21.7%) | 4(20%) | 9(20.9%) | ns |
| Retinopathy | 20(76.9%) | 2(10%) | 22(51.2) | < 0.01 |
| Neuropathy | 17(73.9) | 1(5%) | 18(41.9) | < 0.01 |
| Heart Failure | 12(46.2%) | 0 | 12(27.9) | < 0.01 |
| Cerebral Vascular Stroke | 4(17.4%) | 0 | 4(9.3) | ns |
| Peripheral Artery Disease | 11(42.3%) | 1(5%) | 12(27.9) | < 0.01 |
| HBP | 23(100%) | 12(60%) | 35(81.4) | < 0.01 |
| Dislipemia | 23(100%) | 15(75%) | 31(72.1) | ns |
| Smokers | 4(17.4%) | 5(25%) | 9(20.9) | ns |
| Left ventricular hypertrophy | 19(82.6%) | 0 | 19(44.2) | < 0.01 |
| Diastolic dysfunction | 5(21.7%) | 0 | 8(18.6) | < 0.01 |
| Left ventricular dysfunction | 6(26.1%) | 3(15%) | 9(20.9) | < 0.01 |
| MP in total xμl | 33 004(7272) | 24 745(5791) | < 0.01 | |
| ME xμl | 191.2(218) | 62.8(1.9) | < 0.01 | |
| MP xμl | 701(639) | 441(310) | ns |
Conclusions
The increase in total MPs and EMPs observed in patients on HD with a higher number of CVD non-thrombogenic episodes in the diabetic population studied, could be related to the lack of MPs difference observed.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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