Endocrine Abstracts

Background and aimsMonogenic forms of diabetes caused by a single gene defect include maturity onset diabetes of the young (MODY), neonatal diabetes mellitus and syndromic forms. They are estimated to account for 1–3% of all diabetes cases, but the prevalence is higher among pediatric patients without islet autoantibodies (AAB). Despite presenting with insulin deficiency, many patients can be treated with anti-hyperglycaemic agents to stimulate the...

ObjectiveTo study the predictive value of autoantibodies in progression to type 1 (T1DM) and type 2 (T2DM) diabetes after gestational diabetes (GDM) in a 23-year follow-up study. BackgroundWomen with GDM are at high risk for T2DM later in life, but also the risk of T1DM is increased. We have previously reported a prospective 6-year cohort study showing an association of islet cell and glutamic acid decarboxyl...

BackgroundPrevalence of hypogonadism has been reported as high as 50% in men with T2DM and/or obesity. ADA and AACE Guidelines recommend assessment of hypogonadism in men with T2DM and obesity.Material and methodsIn a registry of 865 men with hypogonadism, 361 men (41.7%) had T2DM. 183 received TU 1000 mg/12 weeks (T-group), 178 opted against treatment (CTRL). Changes over time between groups were compared an...

Universal reach of diabetes care and assurance of minimum standard of care is a milestone yet to be achieved. Application of artificial intelligence/machine learning (AI/ML) for diabetes care can help solve both these aspects of diabetes care.ObjectiveCreating a clinical decision support system using AI/ML approach for predicting best anti-diabetes drug class to be introduced to help optimally manage glycaemic control in people liv...

Background Maturity Onset Diabetes of the Young (MODY) constitutes a genetically and clinically heterogeneous type of Monogenic Diabetes (MD), characterized by early onset of hyperglycemia, autosomal dominant inheritance and defect in β-cell insulin secretion. To date, various MODY subtypes have been reported, each one of a distinct genetic etiology. Materials and methods A total of 114 patients of Greek orig...

Insulin is a major endocrine hormone able to regulate whole-body energy disposal and lipid metabolism. Particularly, insulin stimulates the renewal of the adipose tissue (AT) via activation of insulin receptors (IR) consisting of two splicing variants: a short isoform (IRa) involved in cell proliferation, and a long isoform (IRb) mainly implicated in metabolic responses. The contribution of these isoforms to the AT expansion is still poorly understood. We investigated the expr...