Endocrine Abstracts

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Thyroid hormone is long known for its profound effect on body temperature regulation. Patients suffering from hyperthyroidism display elevated body temperature and are sensitive to heat, while hypothyroid patients are cold sensitive. The precise regulation of body temperature by thyroid hormone, however, has been incompletely understood. In our recent studies, we have studied the thermogenic effects of the hormone in a mouse model in detail. We observed that the body temperatu...

Synthetic glucocorticoids (GCs) are widely used in clinical practise to treat various inflammatory disorders including rheumatoid arthritis, asthma and some malignancies. Although generally well tolerated, long-term, especially high dose use can lead to metabolic side effects. We have developed a mouse model of GC treatment in drinking water, using corticosterone (Cort, the endogenous GC in rodents), which recapitulates many of the side-effects in patients treated with GCs. Af...