Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Symposia

Symposium 16: Splicing in endocrine-related cancers

ea0073s16.2 | Symposium 16: Splicing in endocrine-related cancers | ECE2021

Alternative splicing in breast cancer

Gahete Manuel D

The dysregulation of the splicing process has emerged as a novel hallmark of metabolic and tumor pathologies. Specifically, in breast cancer (BCa), which represents the most diagnosed cancer type among women worldwide, several oncogenic splicing variants have been reported to have a relevant pathophysiological role. This is the case of the splicing variants of HER2 gene, or the In1-ghrelin and SST5TMD4 isoforms, which exhibit oncogenic roles, increasing the malignancy, poor pr...