ECE2021 Presented Eposters Presented ePosters 5: Thyroid (8 abstracts)
Pilot study with the luca device to optimize the diagnosis of thyroid cancer: preliminary results
Gloria Aranda Velazquez 1 , Lorenzo Cortese 2 , Sabina Ruiz 3 , Mattia Squarcia 4 , Felicia Hanzu 3 , Irene Halperin 3 , Davide Contini 5 , Alberto Dalla Mora 5 , Turgut Durduran 2 & Mireia Mora 3
1Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Group of Endocrine Disorders., Barcelona, Spain; 2Institut de Ciències Fotòniques (ICFO), Barcelona, Spain; 3Hospital Clinic, Endocrinology and Nutrition Department, Barcelona, Spain; 4Hospital Clinic, Radiology Department, Barcelona, Spain; 5Politecnico di Milano, Physic Department, Milan, Italy
Introduction
Diffuse optic techniques exploit the capability of penetration of near infrared light to investigate the properties and physiology of tissues. Based on this property, the LUCA device (Laser and Ultrasound Co-Analyzer of Thyroid nodules), a multi-modal device that combines two different diffuse optical techniques – time resolved and diffuse correlation spectroscopies – with ultrasound in the same transducer, has been developed with the aim of optimizing the study of the thyroid nodules.
Materials and Methods
Pilot study that included 11 controls without thyroid pathology (normal thyroid function and ultrasound with negative antibodies) and 31 patients with thyroid nodules (13 with benign nodules, 10 with multinodular goiter and 8 with malignant nodules all confirmed by histology study). All of them were assessed with the LUCA device, using a pre-established protocol. Measurement of both lobes and sternocleidomastoid muscles (MECM) was performed, in addition to nodule determination in patients. In the preliminary analysis using mixed linear effect models, 4 variables were assessed: total Hemoglobin concentration (THB), Tissue oxygen saturation (StO2), dispersion coefficient at a wavelength of 785 nm (µs) and blood flow index (BFI).
Results
The study in controls (54.5% women, 35.3 ± 6.2 years) showed that LUCA can differentiate between thyroid tissue and MECM (P <0.05 for the 4 variables). The study in patients with nodular pathology (77.4% women, 52.2 ± 2 years) has shown a wide variability of the variables studied. The study using ROC curve in patients with single nodules suggests that the model that combines µs of the nodule together with the difference in THB between the nodule and the ipsilateral MECM offers an AUC of 0.92 with a Sensitivity = 100% and Specificity = 77% to differentiate between benign and malignant nodules.
Conclusions
Although this is a preliminary analysis, current results suggest that diffuse optics could help to optimize the diagnosis of malignant thyroid nodules. The study needs to be expanded with other diffuse optics variables along with ultrasound variables.
This project has been carried out thanks to the granting of a HORIZON 2020, Nº: 688303.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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