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Endocrine Abstracts (2021) 73 PEP7.1 | DOI: 10.1530/endoabs.73.PEP7.1

ECE2021 Presented Eposters Presented ePosters 7: Diabetes, Obesity, Metabolism and Nutrition (8 abstracts)

Effects of testosterone therapy on morphology and grade of NAFLD in obese men with functional hypogonadism and type 2 diabetes

Kristina Groti Antonic

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University Medical Center Ljubljana, Department of Endocrinology, Diabetes and Metabolic Diseases, Ljubljana, Slovenia


Aims

Non-alcoholic fatty liver disease (NAFLD) is emerging as a public health issue worldwide, is highly prevalent in patients with type 2 diabetes (T2D), and is linked to obesity, insulin resistance and atherogenic dyslipidemia. We aimed to evaluate effects of testosterone therapy (TTh) on morphology and grade of NAFLD in obese men with functional hypogonadism (FH) and T2D.

Research design and methods

55 obese males with FH and T2D participated in a two-year (first year double-blind, placebo-controlled study, second year follow-up) clinical trial. Total, calculated free and calculated bioavailable testosterone levels, fasting plasma glucose, glycated hemoglobin A1c, lipids (total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides), prostate specific antigen, routine blood tests (complete blood count, electrolytes, urea, creatinine, liver tests) were assessed at baseline, 12 and 24 months. Liver ultrasounds for NAFLD grade assessments were performed at the beginning and after two years. T-test and Wilcoxon’s signed rank were used to detect changes from baseline. Normality of distribution of data was assessed with ShapiroWilk test.

Results

Participants were randomized into two groups. Group T (n = 28) received 1000 mg testosterone undecanoate (TU) both years of the study while group P (n = 27) received placebo first year and TU second year. Liver assessment showed improvement in NAFLD grades at statistically significant level (P <0.001) after two years of TRT. TTh normalized testosterone levels in both groups within first year and stayed in normal range after the second year of the study. No adverse events (prostate carcinoma, cardiovascular events) or side effects of TRT have been observed over the two-year course of this trial.

Conclusions

Two-year therapy with testosterone undecanoate normalized serum testosterone levels, reduced NAFLD grade, and quells the symptoms of hypogonadism in obese men with functional hypogonadism and T2D.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

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