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Endocrine Abstracts (2021) 73 PL3.1 | DOI: 10.1530/endoabs.73.PL3.1


Neoplasia and Endocrine Differentiation Research Group. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela. Santiago de Compostela, Spain. This has been an extraordinary year, where scientists have not been able to get close to the laboratory in many months. However, in the pituitary/hypothalamus we have outstanding contributions. Being at home does not mean stopping thinking, as highlighted by interesting reviews on the novelties in therapeutic peptides targeting GPCRs, new causes of hypopituitarism, DNA damage or pituitary stem cells. In pituitary tumours, use of several omics (mutations, genome alterations, mRNA expression, miRNA clustering, and methylation patterns) in a pangenomic study is a superb contribution, followed by other confirmatory studies allowing understanding of their cellular origin and pre-selection of patients responding better to analogs. At a functional level, we will highlight how the continued activation of the cAMP pathway increases the probability of DNA damage, how hypoxia activates PKA after repressing its regulatory subunits, and what is the molecular protein surface when GHRH activates its GHRHR receptor, obtained through cryo-EM studies. The GPR101 receptor mouse model explaining human pathology but also raising intriguing questions has been one of the milestones of this year. Single-cell RNA sequencing in normal tissue identifies the most abundant genes expressed in an individualized cell; collecting a sufficient number of unique cells it is possible to characterize the different populations of an organ. We have contributions in the changing populations during embryonic development of human pituitary, and several in populations of the mice hypothalamus. At a functional level, we have the role of histone H3 methyl-transferase in the development of GHRH neurons, a new relationship between lysosomes and primary cilium in the early stages of life with consequences in adiposity, or precocious puberty induction by protein signals or ceramides in animal models relevant to the human situation. New and surprising hypothalamic neural circuits in mice controlling metabolism, open exciting possibilities about its existence in humans.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

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