ECE2021 Symposia Symposium 13: TGF-β signalling in ovaries in women with PCOS (3 abstracts)
LH-receptor activity and interaction with TGF-β family members in women with PCOS
Lisa Owens 1 , Stine Gry Kristensen 2 , Avi Lerner 1 , Aylin Hanyaloglu 1 , Kate Hardy 1 , Claus Yding Andersen 2 & Stephen Franks 1
1Institute of Reproductive & Developmental Biology, Imperial College London; 2Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital, University of Copenhagen
The luteinising hormone/chorionic gonadotropin receptor (LHCGR) plays an essential role in ovarian follicular function, mediating the action of LH on theca cell steroidogenesis and, in the preovulatory follicle, on granulosa cell (GC) steroid production and the ovulatory cascade. Following ovulation, LH (and CG) are responsible for maintenance and function of the corpus luteum. Arrested antral follicle development in PCOS is characterised by premature responsiveness of GCs to LH and recent studies in our laboratory have indicated that LHCGR mRNA is increased in GCs of small, human antral follicles (hSAFs). A similarly increased gene expression of LHCGR was observed in granulosa-lutein cells (GLCs) from PCOS women. Several previous studies point to the interaction of LH with members of the TGF-β family. TGF-β’s, activin, inhibins and AMH have all been implicated in modulating LH action in both theca and granulosa cells. In our recent study we found that aberrant expression of LHCGR in GCs of hSAFs in PCOS, was associated with increased expression of inhibin A, but not of inhibin B, AMH, AMH receptor 2 (AMHR2) or follistatin. Nevertheless, there are functional studies that implicate AMH in abnormalities of gonadotropin-induced steroidogenesis in women with PCOS and there remains considerable scope for further investigation in attempting to understand what role the interaction between gonadotropins and members of the TGF-β family has to play in the mechanism of anovulation in PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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