Searchable abstracts of presentations at key conferences in endocrinology
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ESE Young Endocrinologists and Scientists (EYES) Annual Meeting

ea0075m01 | Metabolic Bone | EYES2021

Effect of perinatal nutritional patterns on skeletal properties in adult Wistar rat offspring

Mili Nikoletta , Eleftheriades Makarios , Paschou Stavroula , Syggelos Nikolaos , Augoulea Areti , Armeni Eleni , Kaparos George , Palaiologou Anastasia , Panoulis Konstantinos , Vafai Homeira , Dontas Ismene , Marinou Katerina , Vaggos George , Raptou Panagiota , Vlahos Nikolaos , Lambrinoudaki* Irene , Nicolaides* Kypros H

Objectives: This study aimed to assess the results of different perinatal nutritional patterns on skeletal development and insulin regulation of one-year-old Wistar rats.Methods: Three different diet regiments [Control Diet, (CD), food-restricted (FR), or fat-fed (FF)] were randomly provided to sixty-seven primigravid rats from the 12th till the 21st gestational date when they gave birth and throughout the 25-day lactation period. According to...

ea0075m02 | Metabolic Bone | EYES2021

Unmasking of subclinical sarcoidosis due to cholecalciferol overdose: A case report

Baratam Hari Kiran , Kalra Pramila

Background: Hypercalcemia is not uncommon in granulomatous disorders, especially sarcoidosis and tuberculosis. Prevalence in sarcoidosis may be 2-63%, depending on the population studied. Uncontrolled synthesis of 1,25-dihydroxyvitamin-D by the macrophages is the underlying mechanism. Here we present a case of hypercalcemia, initially thought to be due to hypervitaminosis-D but later diagnosed to have sarcoidosis.Case Presentation: This 49-year-old gentl...

ea0075m03 | Metabolic Bone | EYES2021

Management of a rare life-threatening parathyroid carcinoma

Zelano Lorenzo , Maggio Ettore , Veleno Miriam , Mura Chiara , Morgante Cesare , Antonio Rota Carlo , Pontecorvi Alfredo

Background: Parathyroid carcinoma (PC) is rare, usually presenting with hyperparathyroidism and severe hypercalcemia. A standardized diagnostic, prognostic and therapeutic approach has not been provided yet and TNM staging algorithm is not universally accepted. Surgery is the first-choice treatment and is the only effective therapy to control hypercalcaemia. Chemo- or radio-therapy, local treatments or novel drugs should be reserved to selected cases.Cas...

ea0075m04 | Metabolic Bone | EYES2021

The elderly patients with very high dose vitamin D level: Often present with normocalcemia

Batman Adnan , Altuntas Yuksel

Objective: We aimed to determine the risk of hypercalcemia in a geriatric population with very high dose levels of 25-hydroxy-vitamin D (25(OH)D)Patients and Method: This study was designed as a retrospective, cross-sectional two-center study for examining the elderly patients with very high 25(OH)D levels (>88ng/ml) between January 2014 and December 2019. After recruitment, subgroup analyses of the patients were performed based on their calcium and ...

ea0075m05 | Metabolic Bone | EYES2021

A case report of bisphosphonate induced osteonecrosis of jaw

Kolla Bharathi , PR Manjunath , Boya Harshitha , Acharya Himamshu

Introduction: Bisphosphonates are widely used to treat osteoporosis, hypercalcemia of malignancy and multiple myeloma. Albeit rare, bisphosphonate induced osteonecrosis of jaw is serious adverse event which significantly affects quality of life. Clinical presentation includes gingival ulceration, exposed necrotic bone in the oral cavity. In severe cases it may cause spontaneous pain, tooth mobility and pathological fractures.Case Report: A 70-year-old ma...

ea0075m06 | Metabolic Bone | EYES2021

Osteogenesis imperfecta- A novel pathogenic variant

Sriramaneni Nikitha , Selvan Chitra , Acharya N Himamshu , Naushad Altaf Ali

Background: Osteogenesis imperfecta is a systemic connective tissue disorder characterized by low bone mass and bone fragility leading to low-trauma fractures or fractures in atypical locations. Extraskeletal manifestations may include dental anomalies, blue-gray sclera, hearing loss, joint hypermobility, muscle weakness, cardiovascular and pulmonary complications.Case presentation: A 7year old boy presented with a history of fracture right femur 1 month...

ea0075m07 | Metabolic Bone | EYES2021

Familial hypocalciuric hypercalcaemia or primary hyperparathyroidism?

Hirwa Kagabo , Patel Nishchil , Biaye Abraham , Flanagan Daniel

Background: Primary hyperparathyroidism is the commonest cause of hypercalcemia. Current guidelines advise to rule out familial hypocalciuric hypercalcemia (FHH) when evaluating hypercalcemia. It is widely considered that FHH is associated with low urine calcium creatinine clearance ratio (CCCR). However, low CCCR can also occur in Primary hyperparathyroidism.Case: A 30 years lady presented with hypercalcemia and high parathyroid hormone (PTH). She had a...

ea0075m08 | Metabolic Bone | EYES2021

Safety and efficacy of PTH 1-34 and 1-84 therapy in chronic hypoparathyroidism: a meta-analysis of prospective trials

Hasenmajer Valeria , Puliani Giulia , Sada Valentina , Tarantino Chiara , Lenzi Andrea , Isidori Andrea

Introduction: Hypoparathyroidism is the only endocrine deficiency for which replacement therapy with the missing hormone is not part of the clinical practice. High quality evidence on the use of PTH 1-34 or PTH 1-84 in hypoparathyroidism is missing.Objective: We aim to evaluate the efficacy and safety of PTH 1-34 and PTH 1-84, and to compare the two treatments when possible.Methods: We searched databases up to March 2021 for random...

ea0075m09 | Metabolic Bone | EYES2021

Vitamin D and geriatric syndromes in centenarians

Savicheva Anna , Eruslanova Ksenia , Dudinskaya Ekaterina , Matchekhina Luba

Aim of the study: To assess vitamin D levels in centenarians and its interaction with the most common geriatric syndromesMaterials and Methods: It was a longitudinal study, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and МOCA scores. QoL questionnaires were used as well. In all pat...

ea0075m10 | Metabolic Bone | EYES2021

Vitamin D status and phosphorus-calcium metabolism in children with congenital epidermolysis bullosa

Pronina Irina , Pronina Irina Yu. , Makarova Svetlana G. , Murashkin Nikolay N. , Yasakov Dmitry S. , Vershinina Marina G.

Introduction: Congenital dystrophic epidermolysis bullosa (CDEB) is a rare genetic multisystem disease. Life expectancy of the patients has increased and the prevention of the delayed complications including osteoporosis has become relevant.Aim of the study: To study vitamin D status and phosphorus-calcium metabolism in the children with CDEB.Methods and materials: The study included 32 patients with CDEB, aged from 7 months to 18 ...

ea0075m11 | Metabolic Bone | EYES2021

Elastography in hyperparathyroidism – decision algorithm

Cotoi Laura , Borlea Andreea , Amzăr Daniela , Sporea Ioan , Schiller Adalbert , Schiller Oana , Nicuşor Pop Gheorghe , Dana Stoian

Background: Primary hyperparathyroidism is a common disorder of the parathyroid glands and the third most frequent endocrinopathy, especially among elderly women. Secondary hyper-parathyroidism is a common complication of chronic kidney disease, associated with high cardiovascular morbidity and mortality. In both primary and secondary hyperparathyroidism, the need to correctly identify the parathyroid glands is mandatory for a better outcome. Elastography can be an effective t...

ea0075m12 | Metabolic Bone | EYES2021

Management considerations for adults with x-linked hypophosphatemia: A case report

Thadani Puja , Khan Uzma , Murthy Narasimha , Rao Ranganatha , Sankar Sailesh , Randeva Harpal

Background: X-linked hypophosphatemia (XLH) is a rare, hereditary, progressive musculoskeletal disorder. Prompt diagnosis and treatment in childhood ensures adequate bone matrix mineralization and skeletal growth. There is no consensus on indications for treatment in adult patients.Case Presentation: A 25 year old female was referred to endocrinology with a right ankle fragility fracture. She was known to have XLH, diagnosed in Poland at the age of 1 yea...

ea0075m13 | Metabolic Bone | EYES2021

Hypoparathyroidism after total thyroidectomy in a woman who underwent to bariatric surgery: A case report

Maggio Ettore , Veleno Miriam , Rossi Laura , Novizio Roberto , Emanuele Rizzo Gaetano , Morgante Cesare , Locantore Pietro

Background: Hypoparathyroidism (HypoPT) is characterized by low calcium and parathyroid hormone (PTH), often secondary to thyroid surgery. Treatment consists in activated vitamin D and calcium supplementation. Such treatment may be difficult in patients with malabsorption as calcium usually requires an acid environmental to dissolve, while calcitriol needs an intact intestine for a full absorption.Case report: A 36-year old woman had a history of sleeve ...