Endocrine Abstracts

Loss of beta cell mass in the pancreas characterises type 1 and late-stage type 2 diabetes, resulting in a reduction of insulin levels. The pancreas has a very limited regenerative potential during homeostasis. Despite its quiescent nature, recent in vivo models suggest that a certain degree of regeneration and cellular interconversion is possible in the adult pancreas. The molecular regulation of this plasticity shares remarkable similarities with pancreas beta cell different...

Abstract Unavailable...

Abstract Unavailable...