Endocrine Abstracts

There is a plethora of information about the extragonadal expression of gonadotrophin receptors (R), i.e. for LH/hCG and FSH, many of the studies published in high-profile journals. LHCGR has been found to be expressed in almost all organs of the body, and FSHR is expressed in fat and bone tissues, as well as in multiple malignant tumours. On the basis of these findings it has been proposed that direct gonadotrophin action participat...

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Insulin-like peptide 3 (INSL3) is a peptide hormone secreted exclusively in boys and men by the mature Leydig cells of the testes. It acts through a unique G-protein-coupled receptor, called RXFP2. In the female INSL3 regulates ovarian antral follicle growth. Whereas INSL3 in the male foetus is responsible for the first phase of testicular descent, in the adult it appears to support spermatogenesis and bone health. Importantly, it is...