Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2021

Edinburgh, United Kingdom
08 Nov 2021 - 10 Nov 2021

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Join us in Edinburgh for the flagship event of the Society for Endocrinology


Nuclear receptors in male reproduction

ea0077s2.1 | Nuclear receptors in male reproduction | SFEBES2021

Liver X Receptors (LXR)s and testicular function

Jarvis Sheba , Gethings Lee , Gadaleta Raffaella , Leach Damien , Claude Emmanuelle , Moschetta Antonio , Winston Robert , Williamson Catherine , Bevan Charlotte

Liver X receptors (LXRs) are are ligand-dependent transcription factors, members of the nuclear receptor superfamily of transcription factors. In humans two LXR isoforms exist, LXRα (NR1H3) and LXRβ (NR1H2). LXRα is expressed predominantly in metabolically active tissues, while LXRβ is expressed in the majority of tissues. They have long been known to have critical roles in regulation of lipid metabolism, particu...

ea0077s2.2 | Nuclear receptors in male reproduction | SFEBES2021

Bile acid metabolism and nuclear receptors in male reproduction

Volle David

Over the last decades, studies using pharmacological approaches and transgenic mouse models have defined the major roles of bile acids as signaling molecules. Bile acids control many physiological functions such as lipid homeostasis, glucose, and energy metabolisms. In the last years, bile acids have been demonstrated to control male reproductive function. Here, we will highlight the impacts of bile acids on testicular physiology fo...