Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2021) 77 P25 | DOI: 10.1530/endoabs.77.P25

SFEBES2021 Poster Presentations Bone and Calcium (22 abstracts)

Seasonal variations in circulating vitamin D appear gender dependent and may highlight a novel health inequality

Ian Laing 1 , Rebecca Allcock 1 , Michael Aitchison 1 , Karen Perkins 2 & Paul Wignall 1

1Royal Preston Hospital, Preston, United Kingdom; 2Royal Lancaster Infirmary, Lancaster, United Kingdom

Vitamin D is a pleotropic hormone with important actions in a wide variety of cell types. Whilst its role in the endocrine control of calcium metabolism via the active circulating metabolite 1,25- dihydroxy cholecalciferol is widely appreciated, other actions in a range of cells and tissues depend on activation of circulating 25-hydroxy vitamin D by intracrine mechanisms and paracrine actions which may be locally controlled. Of particular interest are the roles of vitamin D pertaining to innate immunity, the antimicrobial response and inflammation which are the focus of considerable study and debate. Dietary sources of vitamin D are generally inadequate and most vitamin D is produced by ultraviolet B exposure of the skin which at temperate latitudes is restricted to the summer months. We aimed to study the seasonal variation of vitamin D in our local adult population (>18y) in Preston Lancashire UK by examining vitamin D requests in our laboratory database. Twelve months of anonymised requests from primary care were retrieved from December 2018 to November 2019 and stratified by month and gender. Vitamin D was requested considerably more frequently in women than men. There was a noticeable seasonal variation in both sexes with the highest values in late summer (July to September) and the lowest values in winter (January to March). Except in July and August values were higher in women. Vitamin D deficiency was more common in men than women and more pronounced in the winter months. These observations suggest a hitherto unrecognised gender related health inequality and lend further support to the use of seasonally adjusted ranges when assessing vitamin D status.

Volume 77

Society for Endocrinology BES 2021

Edinburgh, United Kingdom
08 Nov 2021 - 10 Nov 2021

Society for Endocrinology 

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