Endocrine Abstracts

An increasing number of transgender adolescents seeks medical care. After careful assessment and in the absence of contraindications, adolescents who have entered puberty, wish treatment and can provide informed consent can be treated with a GnRH analogue (GnRHa). This prevents further development of secondary sex characteristics incongruent with gender identity and provides the adolescent time to consider the option to undergo further gender affirming treatment. Studies on th...

The hypothalamic-pituitary-gonadal (HPG) axis is a dynamic endocrine axis, with three main periods of activity - in foetal life, during mini-puberty, and then from puberty into adult reproductive life. Between these periods the axis is dormant and thus difficult to assess, especially in mid-childhood. Inhibin B and anti-Mullerian hormone (AMH) are both markers of gonadal function - of Sertoli cells of the testes and granulosa cells of the ovary - and are very useful investigat...