Searchable abstracts of presentations at key conferences in endocrinology
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48th Meeting of the British Society for Paediatric Endocrinology and Diabetes

Online, Virtual
24 Nov 2021 - 26 Nov 2021

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Oral Communications

Oral Communications 5

ea0078OC5.1 | Oral Communications 5 | BSPED2021

Evaluating UK Referral Criteria for Children with Short Stature in a Tertiary Paediatric Endocrinology Centre

White Gemma , Cosier Shakira , Andrews Afiya , Willemsen Ruben H. , Savage Martin O. , Storr Helen L.

Background: Childhood growth monitoring aims to identify growth failure and detect underlying pathology. According to UK guidance, height <-2.7 standard deviation score (SDS) (<0.4th percentile) is used as the referral threshold. Additional referral criteria include height deficit (HSDS-target height SDS) <-2.0 and height velocity (HV) SDS <-1.3. Lack of routine HV and mid-parental height calculation, combined with stricter cut-offs compared to other European c...

ea0078OC5.2 | Oral Communications 5 | BSPED2021

Evaluation of the discrepancy between free thyroxine (FT4) reference ranges and the impact on clinical investigation of central hypothyroidism

Vickery Susan , Joshi Supriya , Stock Sally , Hulse Tony

Introduction: Free thyroxine (FT4) assays are available on different commercial platforms where manufacturers provide different reference ranges. The lower limit of normal varies considerably between 8 and 13.9 pmol/l depending on the FT4 assay being used. There is concern about the validity of these reference ranges in paediatric populations, especially for the Roche FT4 assay; here there is a tendency for FT4 results to be below age-related lower limits of 13.9 or 13.6 pmol/...

ea0078OC5.3 | Oral Communications 5 | BSPED2021

An investigation of androgen-responsive non-coding RNAs in boys with atypical genitalia without genetic variants in the androgen receptor (AR)

Alimussina Malika , McMillan Martin , Chudleigh Sandra , McNeilly Jane D , Diver Louise A , McGowan Ruth , Tobias Edward S , Ahmed S Faisal

Introduction: Transcriptome analysis of peripheral blood mononuclear cells (PBMC) RNA has identified a set of androgen-responsive non-coding RNAs.Aim: To quantify the androgen-responsive gene expression and investigate its relationship to the testosterone (T) rise following hCG stimulation in boys with no genetic evidence of androgen insensitivity. Methods: Boys with suspected DSD who were evaluated at the Royal Hospital for Childr...

ea0078OC5.4 | Oral Communications 5 | BSPED2021

Virtual exercise sessions: An innovative way of promoting physical activity in children and young people with obesity

Clarke Ellie , Davies Sioned , Senniappan Senthil

The rising prevalence of childhood obesity is a major public health concern. Approximately 21% of children by the age of eleven are clinically obese, with a further 14% classed as overweight. The causes of obesity of childhood obesity are multifaceted, leading to a complex multi-disciplinary management approach. A high proportion of children and young people do not meet the recommended guidelines of a minimum of 60 minutes physical activity per day. In addition to the barrier&...

ea0078OC5.5 | Oral Communications 5 | BSPED2021

B-cell class switching in trans- and cis-gendered healthy young people is differentially influenced by sex hormones

Peckham Hannah , Rosser Elizabeth C , Radziszewska Anna , Robinson George , Martin-Gutierrez Lucia , De Gruijter Nina M , Jury Elizabeth C , Butler Gary E , Ciurtin Coziana

Cis-gender females are known to mount stronger humoral immune responses than cis-gender males. Little is known about the immunophenotypes of transgender individuals on gender-affirming hormonal treatment, despite growing evidence that hormones influence the immune system.Via the process of class-switch recombination (CSR), B-cell immunoglobulin isotype ‘switches’ from early IgM/IgD classes to IgG/IgA/IgE. Whilst important in infection/vaccine responses; switched isot...