BSPED2021 Poster Presentations Miscellaneous (6 abstracts)
Can playing a computer game assess muscle function? Using ability captured through interactive video evaluation (ACTIVE) in duchenne muscular dystrophy
Joseph McElvaney 1 , Claire Wood 1,2 , Kieren G Hollingsworth 1 , Eric Hughes 1 , Robert Muni Lofra 1,3 , Anna Mayhew 1,3 , Jassi Sodhi 1,3 , Meredith James 1,3 , Tim Cheetham 1,2 & Volker Straub 1,3
1Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; 2Department of Paediatric Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom; 3John Walton Muscular Dystrophy Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
Introduction: Duchenne muscular dystrophy (DMD) is associated with progressive decline in muscle function and loss of ambulation in the teenage years. Objective assessments of upper limb performance are required but functional assessments and magnetic resonance imaging (MRI) are time consuming and costly. ACTIVE-seated (Ability Captured Through Interactive Video Evaluation) is a fun, inexpensive, movement tracking video game that can measure Functional Reaching Volume (FRV).
Aim: To establish whether data obtained using ACTIVE-seated are comparable to measures of muscle performance and pathology using functional assessment and MRI.
Methods: Data were obtained from 15 adolescent boys with DMD on 3 occasions (clinical trial NCT02571205). ACTIVE-seated output (FRV - lower, middle and upper) was compared with Performance of Upper Limb 2.0 (PUL), Brooke Upper Extremity Scale, myometry and MRI (arm fat fraction, using 3-point Dixon and T2 relaxation).
Results: Data at 1 year were analysed. ACTIVE-seated correlated with Brooke score (P=0.0275) and was related to whole arm PUL values (r=0.941,P < 0.0005), fat fraction (r=-0.6923,P=0.01226) and contractile cross-sectional area (r=0.5769,P=0.0390). Lower FRV had close associations with grip myometry (r=1.7909,P=0.0037). Upper FRV correlated closely with shoulder PUL (r=0.89713,P < 0.0005) and shoulder abduction myometry (r=0.7063, P=0.0102). There was no association with T2 relaxation time (P=0.5879) which acted as a control in this context.
Conclusion: The close relationship between ACTIVE-seated data and traditional functional assessments as well as quantitative arm muscle MRI suggests that it may be a useful addition to existing assessment tools.
Volume 78
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