Searchable abstracts of presentations at key conferences in endocrinology
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Belgian Endocrine Society 2021

ea0079001 | Abstracts | BES2021

The STE-20 kinase TAOK3 regulates obesity-associated metabolism and type 2 immunity in murine adipose tissue

Bastiaan Maes , Farzaneh Fayazpour , Leen Catrysse , Guillaume Lornet , De Velde Evelien Van , Caroline De Wolf , Sofie De Prijck , Justine Van Moorleghem , Manon Vanheerswynghels , Kim Deswarte , Benedicte Descamps , Christian Vanhove , Hamida Hammad , Sophie Janssens , Bart N Lambrecht

Aim: Healthy adipose tissue contains numerous innate and adaptive immune cells that carry a type 2 cytokine immune signature, controlled by IL-33 and reflected by accumulation of ST2+ T regulatory cells (Tregs), type 2 innate lymphoid cells (ILC2s), and alternatively activated macrophages. These type 2 responses are lost in mice or humans on high-caloric diets that lead to obesity. Understanding how type 2 immunity is regulated in adipose tissue could contribute to ...

ea0079002 | Abstracts | BES2021

Identification of myokines potentially involved in the improvement of glucose homeostasis induced by bariatric surgery

Laura Orioli , Julien Derop , Mickael Canouil , Kiswendsida Sawadogo , Louise Deldicque , Pascale Lause , Marie de Barsy , Audrey Loumaye , Yannick Deswysen , Benoit Navez , Amelie Bonnefond , Jean-Paul Thissen

Background and aims: The contribution of myokines to improved glucose homeostasis induced by bariatric surgery is unknown. Our study aims to identify myokines potentially improving glucose homeostasis following bariatric surgery.Patients and methods: Obese insulin-resistant patients were evaluated before and 3 months after bariatric surgery, i.e. a sleeve gastrectomy or a Roux-en-Y gastric bypass (n62). Muscle biopsies were taken from vastus lat...

ea0079003 | Abstracts | BES2021

Gene expression signatures of target tissues in endocrine and non-endocrine autoimmune diseases. Présenté par Prof. Miriam Cnop

F Szymczak , M. L. Colli , M. J. Mamula , C Evans-Molina , D. L Eizirik

Objectives: Autoimmune diseases are typically studied with a focus on the immune system, and less attention is paid to responses of target tissues exposed to the immune assault. We aimed to evaluate, based on available bulk RNA sequencing data, whether inflammation induces similar molecular signatures in the target tissues of five autoimmune diseases, namely type 1 diabetes (T1D), Hashimoto’s thyroiditis (HT), rheumatoid arthritis (RA), multiple sclerosis (MS) and systemi...

ea0079004 | Abstracts | BES2021

Effect of glucocorticoid vs CRH treatment during sepsis on pituitary ACTH processing

Arno Teblick , Lauren De Bruyn , Perre Sarah Vander , Lies Langouche , Greet Van den Berghe

Purpose: Sepsis is hallmarked by high circulating glucocorticoids in face of low plasma adrenocorticotropic hormone (ACTH) (1). At the hypothalamic-pituitary level, ongoing stress-induced corticotropin-releasing hormone- (CRH) and arginine vasopressin- (AVP) driven expression of the ACTH-precursor POMC coincides with impaired proprotein convertase 1 (PC1/3)-mediated processing into ACTH, with ultimately leaching of unprocessed POMC into the circulation (2). Despite uncertainty...

ea0079005 | Abstracts | BES2021

Fragility fractures in postmenopausal women: development of 5-year prediction models using the FRISBEE study

Felicia Baleanu , Michel Moreau , Alexia Charles , Laura Iconaru , Rafik Karmali , Murielle Surquin , Florence Benoit , Aude Mugisha , Marianne Paesmans , Michel Rubinstein , Serge Rozenberg , Pierre Bergmann , Jean- Jacques Body

Context: Individualized fracture risk may help to select patients requiring a pharmacological treatment for osteoporosis. FRAX and the Garvan fracture risk calculators are the most used tools, though their external validation has shown significant differences in their risk prediction ability.Objective and Methods: Using data from the FRISBEE study, a cohort of 3560 post-menopausal women aged 60-85 years, we aimed to construct original 5-year fracture ris...

ea0079006 | Abstracts | BES2021

The potential role of androgens as early determinants of body composition and metabolic health

Thiberiu Banica , Bruno Lapauw

Introduction: Even in healthy men, androgen levels start decreasing from early adulthood and these decreases are more pronounced in men with an increasing body mass index (BMI). It is, however, unclear to what extent changes in other indices of body composition and metabolic health are associated with changes in sex steroid exposure in healthy men over time.Objective: Investigating longitudinal changes in body composition and metabolic health in relation...

ea0079007 | Abstracts | BES2021

Fasting plasma glucose level to determine the need for an OGTT to screen for gestational diabetes mellitus

Kaat Beunen , Astrid Neys , Paul Van Crombrugge , Carolien Moyson , Johan Verhaeghe , Sofie Vandeginste , Hilde Verlaenen , Chris Vercammen , Toon Maes , Els Dufraimont , Christophe De Block , Yves Jacquemyn , Farah Mekahli , Katrien De Clippel , Den Bruel Annick Van , Anne Loccufier , Annouschka Laenen , Roland Devlieger , Chantal Mathieu , Katrien Benhalima

Aims: To determine the fasting plasma glucose (FPG) level at which an oral glucose tolerance test (OGTT) could be avoided to screen for gestational diabetes (GDM) and to evaluate the characteristics of women across this FPG threshold.Methods: A multi-centric prospective cohort study (BEDIP-N) with 1843 women receiving screening for GDM with a 75g OGTT.Results: A FPG < 78 mg/dl was the FPG cut-off with the best trade-off to limi...

ea0079008 | Abstracts | BES2021

Fast-acting insulin aspart improves glucose control in a real-world setting: a 1-year multicenter study in people with type 1 diabetes using continuous glucose monitoring

Lisa Billion , Sara Charleer , Laurens Verbraeken , Mira Sterckx , Kato Vangelabbeek , Block Nathalie De , Charlien Janssen , Dessel Kristof Van , Eveline Dirinck , Frida Peiffer , Nancy Bolsens , Chantal Mathieu , Pieter Gillard , Christophe De Block

Background and Aims: To evaluate whether switching from traditional mealtime insulin analogs to fast-acting insulin aspart (Fiasp) in routine clinical practice is efficacious and safe in adult people with type 1 diabetes (PWD1) using intermittent or real-time continuous glucose monitoring (iCGM or rtCGM).Methods: Data from 438 adult PWD1 (60% men, age 44.6&pm;16.1 years, duration of diabetes 21.5&pm;14.0 years, iCGM/rtCGM: 391/47, injections/pump: 409/29...

ea0079009 | Abstracts | BES2021

Lipohypertrophy monitoring study (LIMO): effect of injection site rotation and education on glycemic control

N. Bochanen , K. Decochez , E. Heleu , J. Cuypers , C. Vercammen , P. Coremans , G. Vanhaverbeke , S. Shadid , B. Keymeulen , N. Bolsens , C De Block

Background and Aims: Incorrect injection technique can cause lipohypertrophy resulting in unpredictable insulin release. We aimed to assess the impact of a correct injection technique and lipohypertrophy on HbA1c, hypoglycemia and glucose variability.Methods: 171 insulin-injecting people with diabetes were prospectively evaluated for 6 months. 146 subjects completed the study (75 type 1, 71 type 2). They were provided extensive education concerning injec...

ea0079010 | Abstracts | BES2021

Changes in androgen profile in transgender women with or without gonadectomy

Sarah Collet , Meijer Delphine de , Sarah Nobels , Meltem Kiyar , Guy T'Sjoen

Objectives: The European Network for the Investigation of Gender Incongruence (ENIGI) is a multicenter prospective cohort study. All participants receive a standardized gender affirming treatment protocol including regular follow-up visits. The current study compared the changes in androgens upon starting hormone treatment and during follow-up in transgender women (TW) with or without gonadectomy by investigating serum total (TT), calculated free testosterone (cFT), DHEA, DHEA...

ea0079011 | Abstracts | BES2021

A cross-sectional analysis of the association between testosterone and biopsy-proven non-alcoholic fatty liver disease in 134 obese men

Herdt C De , Block C De , A Verrijken , Dessel K Van , S Francque , L Van Gaal , E Dirinck

Background and aims: Low levels of testosterone and non-alcoholic fatty liver disease (NAFLD) in obese men are both linked to the metabolic syndrome, but the independent association between testosterone and NAFLD needs to be elucidated. In this cross-sectional analysis the association between total testosterone (total T) and calculated free testosterone (cFT) on the one hand and NAFLD, non-alcoholic steatohepatitis (NASH) and fibrosis on the other hand was investigated in obes...

ea0079012 | Abstracts | BES2021

The impact of anti-androgen therapy on bone in men treated for paraphilia: a retrospective cohort study

Anais De Landtsheer , Lieslinde Bekaert , Leen Antonio , Dirk Vanderschueren

Background: Guidelines suggest treating paraphilias with androgen-deprivation therapy (ADT). However little evidence is available about the long-term impact on bone and how to manage this adverse event.Aim: The aim of this study is to assess the impact of ADT on bone mass and bone mineral density (BMD) in men treated for hypersexuality with cyproterone acetate (CPA) and GnRH agonists (GnRHa), and to evaluate the effect of treatment with bisphosphonates.<...

ea0079013 | Abstracts | BES2021

Let’s go beyond: The relationship between arterial stiffness and CGM-derived glycemic control in patients with type 1 diabetes

S. Helleputte , P. Calders , B. Lapauw , T. De Backer

Background: In patients with type 1 diabetes (T1D), arterial stiffness is a potential alternative biomarker for cardiovascular (CV) risk as it has recently shown important prognostic value in the development of CVD that is independent from traditional risk factors. Glycemic control by means of HbA1c is a main determinant of arterial stiffness progression, however the relationship with continuous glucose monitoring (CGM)-derived parameters such as time in range (TIR) has not be...

ea0079014 | Abstracts | BES2021

Estimated glucose disposal rate, non-alcoholic fatty liver disease and micro- and macrovascular complications in type 1 diabetes: Towards a new biomarker?

Jonathan Mertens , Jonas Weyler , Luisa Vonghia , Wilhelmus Kwanten , Eveline Dirinck , Sven Francque , Christophe De Block

Background and aims: Insulin resistance is increasingly prevalent in patients with type 1 diabetes (T1D). Insulin resistance is associated with both cardiovascular complications and non-alcoholic fatty liver disease (NAFLD), but its assessment is challenging in T1D due to the technical difficulties of the euglycaemic clamp technique. The estimated glucose disposal rate (eGDR) is a validated alternative to quantify insulin resistance in T1D, but its role in clinical practice is...

ea0079015 | Abstracts | BES2021

Factors associated with early postpartum weight retention in women with gestational diabetes

Caro Minschart , Loran Snoeks , Toon Maes , Block Christophe De , Pottelbergh Inge Van , Nele Myngheer , Pascale Abrams , Wouter Vinck , Liesbeth Leuridan , Chantal Mathieu , Jaak Billen , Christophe Matthys , Babs Weyn , Annouschka Laenen , Annick Bogaerts , Katrien Benhalima

Aims: To identify factors associated with early postpartum weight retention (PPWR) in women with recent gestational diabetes mellitus (GDM).Methods: Multicentric prospective study in women with a recent history of GDM based on the IADPSG criteria at the oral glucose tolerance test (OGTT) 6-16 weeks postpartum. Data obtained from electronic medical records, self-administered questionnaires, clinical examination and blood sample collection were used for th...

ea0079016 | Abstracts | BES2021

Characteristics, pregnancy outcomes and tolerance of screening tests according to the preference of women for the method of GDM screening

Lore Raets , Marie Vandewinkel , Paul Van Crombrugge , Carolien Moyson , Johan Verhaeghe , Sofie Vandeginste , Hilde Verlaenen , Chris Vercammen , Toon Maes , Els Dufraimont , Block Christophe De , Yves Jacquemyn , Farah Mekahli , Katrien De Clippel , Den Bruel Annick Van , Anne Loccufier , Annouschka Laenen , Roland Devlieger , Chantal Mathieu , Katrien Benhalima

Aims: To compare the characteristics, pregnancy outcomes and tolerance of screening tests between women who prefer a two-step screening strategy with a glucose challenge test (GCT), women who prefer an one-step screening strategy with an oral glucose tolerance test (OGTT) and women without clear preference for screening method for gestational diabetes mellitus (GDM). Methods: 1803 women from a Belgian multi-centric prospective cohort study (BEDIP-N study...

ea0079017 | Abstracts | BES2021

Prevalence of and risk factors for sexual dysfunctions in adults with type 1 or type 2 diabetes: Results from Diabetes MILES - Flanders

Cauwenberghe Jolijn Van , Paul Enzlin , Giesje Nefs , Johannes Ruige , Christel Hendrieckx , Christophe De Block , Frans Pouwer

Background and aims: The prevalence of sexual dysfunctions in people with diabetes is still debated and understudied in women. This study examines the prevalence of sexual dysfunction in men and women with type 1 or type 2 diabetes (T1D or T2D) and the associations with clinical and psychological variables.Methods: Adults with diabetes (n756) completed an online survey including questions on sexual functioning (adapted Short Sexual Functional Sc...

ea0079018 | Abstracts | BES2021

Risk for ketonaemia in type 1 diabetes pregnancies with sensor-augmented pump therapy with predictive low glucose suspend compared to low glucose suspend: an open-label crossover RCT

Nes Falco van , Chantal Mathieu , Annouschka Laenen , Pieter Gillard , Katrien Benhalima

Background: Little is known about the influence of the Predictive Low Glucose suspend (PLGS) function of Sensor Augmented Pump therapy on ketone production in patients with type 1 diabetes mellitus (T1DM), compared to the Low Glucose Suspend function. To evaluate the effect, we compared the frequency of elevated ketone levels, the duration of insulin infusion suspension, the glycaemic control and patient satisfaction between the two settings.Methodology:...

ea0079019 | Abstracts | BES2021

COVID-19 & Cushing’s disease in a patient with ACTH-secreting pituitary carcinoma

Jeroen M.K. de Filette , Bastiaan Sol , Gil Awada , Corina E. Andreescu , David Unuane , Duc Nam Nguyen , Sandrine Aspeslagh , Jan Poelaert , Brigitte Velkeniers , Bert Bravenboer

Background : The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of an unprecedented scale, with an ever-growing impact on healthcare systems. The clinical presentation of coronavirus disease 2019 (COVID-19) is diverse, ranging from asymptomatic illness to respiratory failure requiring admission to the intensive care unit (ICU). Risk factors for severe presentation include old age, male gender, underlying comorbidities such as metabolic syndr...

ea0079020 | Abstracts | BES2021

HLA-DR4/DR13 in a patient with durvalumab-induced thyroiditis

Filette de , M.K Jeroen , Rop Jonas De , Stephanie Andre , Lynn De Mey , Sandrine Aspeslagh , Rafik Karmali , der Auwera Bart J Van , Bert Bravenboer

Background: Immune checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 and its ligand (PD-1/PD-L1) are the current standard-of-care for many advanced cancers (1). This novel therapeutic approach comes with its costs in the form of immune-related adverse events (irAE). The underlying mechanisms are not yet fully understood. We explore the role of HLA in endocrinopathy related to ICI therapy using an interes...

ea0079021 | Abstracts | BES2021

Li-Fraumeni syndrome presenting as peripheral precocious puberty caused by a pure androgen-secreting adrenal adenoma

Sofie Ryckx , Jean De Schepper , Willem Staels

Introduction: Precocious puberty in boys is the development of secondary sexual characteristics before 9 years of age. Peripheral precocious puberty (PPP), as opposed to central precocious puberty (CPP), is caused by autonomous secretion of androgens or human chorionic gonadotropin (hCG). Testicular volume, penis size, growth velocity, gonadotropin and androgen levels, and bone age readings aid in diagnosing precocious puberty and in identifying its cause. Distinguishing CPP f...

ea0079022 | Abstracts | BES2021

Isomorphic (KOEBNER) phenomenon induced by insulin injections in psoriasis: a case report

Saartje Thijs , Corinne Degraeve , Peter Coremans

Introduction: Lipohypertrophy is by far the most common skin-related complication of insulin therapy. Less common dermatological complications of insulin injections include lipoatrophy, localized allergic reaction, subcutaneous abscess, localized amyloidosis and hyperpigmentation of the skin at the site of injection. We describe the Koebner phenomenon in an insulin requiring type 2 diabetic patient during a psoriasis flare-up.Case report: A 56-year old w...

ea0079023 | Abstracts | BES2021

Unusual cause of neonatal salt wasting syndrome in a female with subsequent primary amenorrhoea

Sebastien Verdickt , Marie Bex

Introduction: Congenital adrenal hyperplasia (CAH) is the most frequent cause of primary adrenal insufficiency (PAI) in infants and children. The list of genetic causes of PAI has grown extensively in recent years(1). Associated features can provide a clue to identify the underlying defect.Case presentation: A 21-year-old female was referred for endocrinological advice about pregnancy. She had been diagnosed with isolated aldosteron deficiency...

ea0079024 | Abstracts | BES2021

Therapy-resistant hypocalcemia in auto-immune polyendocrine syndrome type 1

Charlotte Verroken , Smet Stephanie De , Marianne Kerrebrouck , David Creytens , Guy T'Sjoen , Bruno Lapauw

A 22-year old female is followed at our department because of genetically confirmed autoimmune polyendocrine syndrome type 1 (APS-1). This was diagnosed at the age of 9 and in this patient characterized by autoimmune hypoparathyroidism, autoimmune hepatitis, autoimmune gastritis and premature ovarian insufficiency. Throughout childhood and puberty, the hypoparathyroidism was treated with moderate doses of calcium citrate (~3g/d) and calcitriol (~1.5µg/d), nevertheless res...

ea0079025 | Abstracts | BES2021

Hypoglycemia after initiation of CFTR modulator therapy in a cystic fibrosis patient without diabetes

Joke Vliebergh , Hakan Bor , Yskout Marie , Lieven Dupont , Natalie Lorent , Bleyenbergh Pascal Van , Pieter Gillard , der Schueren Bart Van , Ann Mertens , Chantal Mathieu , Roman Vangoitsenhoven

Background: Cystic fibrosis (CF) is a genetic disorder in which a dysfunctional cystic fibrosis transmembrane regulator (CFTR) chloride channel can result in multimorbidity, including severe respiratory disease and reduced pancreatic exocrine secretion and diabetes. Recently, CFTR modulator therapy, has emerged with the potential of improving respiratory function and remission of diabetes. The effect of CFTR modulator therapy on pancreatic function in patients without preexist...

ea0079026 | Abstracts | BES2021

Thinking beyond guidelines: an atypical case of adrenal incidentaloma

Joke Vliebergh , Cleynenbreugel Ben Van , Sascha Vermeer , Raf Sciot , Marie Bex

Background: An adrenal incidentaloma is defined as an adrenal mass larger than 1 cm, detected on imaging performed for an indication other than evaluation of adrenal disease. Following the European Society of Endocrinology clinical practice guideline, assessment of malignancy by imaging and hormone excess should be done simultaneously(1). To investigate whether an adrenal mass is functionally active, a thorough clinical examination is required, extended with a 1mg o...