Searchable abstracts of presentations at key conferences in endocrinology
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UKI NETS 19th National Conference

ea0080p1 | Abstracts | UKINETS2021

Setting up of a national liver transplant programme for neuroendocrine tumour liver metastases in UK and Ireland: opportunities for clinical study and research

Shah Tahir , Moore Joanna , Venkataraman Hema , Caplin Martyn , Smith Stacey , O'Toole Dermot , Hoti Emir , Dasari Bobby , Ford Samuel , Mazzaferro Vincenzo , Gibbs Paul , Manas Derek , Isaac John , Thorburn Douglas

Background: Transplantation for cancer indications is evolving rapidly in UK and Ireland. Liver transplantation [LT] for unresectable neuroendocrine tumour liver metastases [NET LM] is one of three new cancer indications. It has the potential to significantly improve survival outcomes however, transplant benefit has likely been achieved only by highly experienced Centre(s). Since eligible patients for transplantation also have excellent prognosis with standard management, care...

ea0080p2 | Abstracts | UKINETS2021

Vitamin deficiencies in patients with neuroendocrine tumours

Sivananthan Mathoorika , Khan Mohid , Dowd Charlotte

Background: Neuroendocrine tumours (NETs) are a heterogenous group of slow growing tumours with an increasing incidence. Disease-related diarrhoea, surgery and medical treatment can lead to malabsorption, resulting in vitamin deficiencies.Objective: To establish the prevalence of vitamin deficiencies in patients with NETs.Method: Retrospective review of NET patients seen since 2014 in South Wales across 6 health boards. Deficiencie...

ea0080p3 | Abstracts | UKINETS2021

Sex differences and survival of neuroendocrine neoplasia in England 2012–2018

White Benjamin E , Chandrakumaran Kandiah , Wong Kwok , Rous Brian , van Hemelrijck Mieke , Srirajaskanthan Rajaventhan , Ramage John K

Introduction: Sex differences have been noted at different sites of Neuroendocrine Neoplasia in previous registry studies across different countries. Analysis of National Cancer Registry and Analysis Service (NCRAS) data can help to clarify the significance and importance of this factor in England. Aim: To examine neuroendocrine neoplasia incidence and survival by sex, site and stage. Method: A population-based, cohort study was pe...

ea0080p4 | Abstracts | UKINETS2021

The Impact of the Covid-19 Pandemic on Neuroendocrine (NET) services and patients: A quantitative and qualitative analysis

Seneviratne Dilini , Walsh Emma , Finnen John , Munir Alia

Introduction: The response to SARS-CoV-2 lead to interventions to mitigate the pandemic. We retrospectively analysed the effect of changes on key NET services. These included: change in clinic media, absolute change in numbers for endoscopy and bronchoscopy, nuclear imaging, SSA administration and PRRT numbers compared with 2019.Method: The NET database was analysed. Endoscopy rates on a monthly basis were reviewed. Two bespoke postal patient surveys wer...

ea0080p5 | Abstracts | UKINETS2021

Real world overall survival in patients with gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) in a large United Kingdom (UK) tertiary centre

Clement Dominique , Brown Sarah , Halim Mohammed , Dolly Saoirse , Kibriya Nabil , Howard Mark , Prachalias Andreas , Menon Krishna , Srinivasan Parthi , Ramage John , Srirajaskanthan Raj

Introduction: The incidence and prevalence of GEP-NENs is rising worldwide. NENs represent the group off well differentiated neuroendocrine tumours (NET) and poorly differentiated neuroendocrine carcinoma (NEC). NETs can be divided into grade 1 (G1), grade 2 (G2) and grade 3 (G3) based on histological parameters. There exist several studies regarding survival data but these are mainly based on national databases.Aim: To describe the real world overall su...

ea0080p6 | Abstracts | UKINETS2021

Earlier diagnosis of neuroendocrine tumours (NETs) through transformation of the south wales NET service

Gould Harriet , Amin Kapish , Karategos Thanos , Abbas Sarah , Taylor Rebecca , Cook Katherine , Powell Catherine , Hargest Rachel , Phillips Simon , Horwood James , Cornish Julie , Torkington Jared , Khan Mohid

Background: Neuroendocrine tumours (NETs) are heterogeneous cancers with varied survival, arising mainly from the gastroenteropancreatic tract. Delayed diagnosis and mislabelling are widely recognised internationally in midgut NETs with little data describing how to improve diagnosis times. In 2017, transformation of the South Wales NET Service included a change to a gastroenterology-led service model alongside education and forming working relationships with gastroenterologis...

ea0080p7 | Abstracts | UKINETS2021

Sex specific differences in overall survival in patients with pulmonary neuroendocrine neoplasms (NENs) in a large United Kingdom (UK) tertiary centre

Clement Dominique , Brown Sarah , Mulholland Nicola , Sarker Debashis , Giwa Mojisola , Koundouraki Antonia , Ramage John , Srirajaskanthan Raj

Introduction: Pulmonary NENs account for around 2% of all pulmonary malignancy. They are classified histologically into 4 types typical and atypical carcinoids which are generally well differentiated and large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC) which are poorly differentiated. Within the literature there are several reports regarding overall survival on small mainly surgical cohorts, but data for the UK population are lacking. Only a few...

ea0080p8 | Abstracts | UKINETS2021

A 10 year retrospective review of pulmonary neuroendocrine tumours (PulNETs/Carcinoids) in a european tumour centre of excellence

Uchambally Manjima , Munir Alia , Survana Kim , Finnen John

Introduction: Pulmonary neuroendocrine tumours (pulNETs) histologically encompass: small cell, large cell, typical (TC) and atypical carcinoid (AC). Diffuse idiopathic pulmonary neuroendocrine hyperplasia (DIPNECH) is a very rare condition but potentially progress to pulNET and is associated with MEN. Advances in treatment have modified management, and there have been recommendations to use Ki67 for grading. However there is a paucity of randomized studies.<p class="abstex...

ea0080p9 | Abstracts | UKINETS2021

Frontiers in Carcinoid Heart Disease

Denham Samuel , Singh Harjot , Oelofse Tessa , Karim Anwar , Rooney Stephen , Steeds Richard , Shah Tahir

The treatment of patients with carcinoid heart disease (CHD) presents substantial challenges due to the advanced multisystem nature of their disease. Intensive multidisciplinary collaboration and innovative techniques are often required in order to manage these patients. Here we describe two such cases from our institution. A 59-year old gentleman with metastatic NET and CHD was referred to our centre. Transoesophageal echocardiography demonstrated severe tricuspid regurgitati...

ea0080p10 | Abstracts | UKINETS2021

Addressing professional development needs in neuroendocrine cancer nursing

Jervis Nikie , Bouvier Catherine

Adult Neuroendocrine Cancer nursing is a highly specialised field where expertise in both knowledge and appropriate skills can make a significant contribution - ‘especially in the promotion and maintenance of high standards of practice, education for the patient’ and the application of safe evidence-based knowledge and skills ‘the patient requires when diagnosed with a rare disease’ (1). Whilst considered rare, Neuroendocrine Cancer has seen an exponential ...

ea0080p11 | Abstracts | UKINETS2021

Survey of neuroendocrine tumour patients’ experience of quality of care provided by a dedicated NET dietitian

Mair Reena , Bradley Elizabeth , Davis Nancy , Shah Tahir

Background: The Birmingham Neuroendocrine Tumour (NET) service has a full time dedicated NET Dietitian for outpatient and inpatient care since August 2020. An anonymised survey of patient experience was performed to identify ways in which we can improve the service for patients. 87 potential patients were identified. 8 had passed away. 79 questionnaires were sent out. 38 were returned via a self-addressed envelope.Results: • 53% of patients were fir...

ea0080p12 | Abstracts | UKINETS2021

Do patients with small bowel NET tend to be diagnosed late and with advanced disease?

Coldham Christopher , Humphries Sian , Shah Tahir

Patients with small bowel NET may present in a different way from other GPNET patients, with well-established disease and metastases. They may have long term symptoms that are well investigated but remain undiagnosed sometimes for years. To examine this supposition the presenting symptoms and outcomes of the first thirty patients with small bowel NET seen in 2018 were examined. Of these thirty patients eight were female and twenty-two were male with a median age of 64.5 years ...