Pituitary and Neuroendocrinology | 0081 | ECE2022 | European Congress of Endocrinology 2022

ea0081ep640 | Pituitary and Neuroendocrinology | ECE2022

A method for evaluating the results of brain 18F-FDG PET/CT in the diagnosis of MRI-negative ACTH-producing pituitary adenomas.

Tsoy Uliana , Kuritsyna Natalia , Savello Alexander , Cherebillo Vladislav , Ryzhkov Anton , Grineva Elena , Ryzhkova Daria

Background: Detection of MRI-negative ACTH-producing pituitary adenomas is a challenge inthe management of patients with Cushings disease. There are some data on theability of pituitary adenomas to accumulate 18F-fluorodeoxyglucose during the 18F-FDG positron emission tomography and computer tomography (18F-FDG PET/CT). Aim: To study the potential of using a standardized uptake value (SUV) and a tumor &...

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ea0081ep641 | Pituitary and Neuroendocrinology | ECE2022

Patient with pregnancy and possible MEN 2b syndrome: case report

Lobashova Veranika , Kuzmenkova Elena , Dydyshka Yuliya , Shepelkevich Alla

Background: MEN 2b is a highly penetrant disease with an autosomal dominant pattern of inheritance. It includes medullary thyroid carcinoma, pheochromocytomas, and multiple mucosal neuromata. The common feature of all of these tumors is a neuroectodermal origin. Although the clinical phenotype is present in all patients, individual manifestations have a variable presentation and are age dependent. Aim.: We report a case of a patient with possible MEN 2b ...

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ea0081ep642 | Pituitary and Neuroendocrinology | ECE2022

Circulating plasma microRNA in patients with ACTH-dependent cushing’s syndrome.

Malygina Anastasia , Belaya Zhanna , Solodovnikov Alexander , Nikitin Alexey , Koshkin Philipp , Sitkin Ivan , Pikunov Michael , Khandaeva Patimat , Lutsenko Alexander , Trukhina Diana , Lapshina Anastasia , Grigoriev Andrey , Melnichenko Galina , Dedov Ivan

Introduction: Recent studies have shown that microRNA could serve as biomarkers in various types of cancer and other diseases. Aim: To reveal microRNA that differ in patients with Cushings diseases (CD) and Ectopic ACTH-syndrome (EAS) to form a specific panel for differential diagnosis of ACTH-dependent Cushings syndrome (CS).Materials and Methods: Plasma samples from both sinuses and cubital vein were drained during in...

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ea0081ep643 | Pituitary and Neuroendocrinology | ECE2022

Primary hyperparathyroidism response to the somatostatin analogue therapy in a patient with MEN1 syndrome: A case report

Yakovenko Kseniia , Pogosian Karina , Ryzhkova Daria , Belousova Lidiia , Karonova Tatiana , Grineva Elena , Tsoy Uliana

Background: Management of primary hyperparathyroidism (PHPT) in Multiple Endocrine Neoplasia type 1 syndrome (MEN 1) is still a challenge. PHPT developing in MEN 1 is characterized by the involvement of all parathyroid glands. Therefore, by modern guidelines, total or subtotal removal of the parathyroid glands is recommended. But this approach often leads to the development of hypoparathyroidism, adequate correction of which is not always possible. Drug therapy of recurrent PH...

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ea0081ep644 | Pituitary and Neuroendocrinology | ECE2022

Dynamics copeptin and apelin in patients before and after transnasal adenomectomy and their relationship with the development of postoperative hyponatremia

Fargieva Khava , Katamadze Nino , Dzeranova Larisa , Pigarova Ekaterina , Przhiyalkovskaya Elena , Griroriev Andrey , Mokrysheva Natalia

Introduction: Transnasal adenomectomy is the main treatment for various pituitary adenomas. The hypothalamic-pituitary region is the site of synthesis and secretion of several hormones that have a direct effect on sodium-water metabolism, which leads to its frequent violation with the development of central diabetes insipidus and severe transient hyponatremia, the latter of which is the second most important cause of rehospitalization in the postoperative period. Currently, th...

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ea0081ep645 | Pituitary and Neuroendocrinology | ECE2022

Hyponatremia, central diabetes insipidus after transnasal adenometomy and its’ risk factors

Mikhaylova Darya , Dzeranova Larisa , Yu. Rebrova Olga , Pigarova Ekaterina , Rozhinskaya Ludmila , Grigoriev Andrey , Ivashenko Oksana , Azizyan Vilen

Objectives: To assess the frequencies of hyponatremia and central diabetes insipidus (CDI) after transnasal adenomectomy and to identify its risk factors.Patients and methods: The study included 152 patients aged 18 to 65 years (median [Q1; Q3] 40 [31; 52]) who underwent endoscopic endonasal transsphenoidal surgery due to Cushings disease, acromegaly, prolactinoma, non-functioning pituitary adenoma, thyreotropinoma or Nelsons syndrome at Endo...

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ea0081ep646 | Pituitary and Neuroendocrinology | ECE2022

A clinical case of hypogonadism and anosmia associated with a new mutation of the KAL1/ANOS1 gene: a preliminary report

Del Prete Michela , Sacco Gianleone Di , Bonomi Marco , Vignati Federico , Muratori Fabrizio , Persani Luca

Introduction: Kallmann syndrome (KS) is a genetic condition characterized by the association of anosmia or hyposmia and GnRH deficiency resulting in congenital hypogonadotropic hypogonadism (CHH). Different genes can be implicated in KS, and the most frequent allelic variant occurs in the KAL1/ANOS1 gene in the X-linked form. Differential diagnosis is often made with other rare genetic diseases as CHARGE syndrome (CS) that includes hypogonadism, hyposmia and several organ defe...

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ea0081ep647 | Pituitary and Neuroendocrinology | ECE2022

Sellar plasmacytoma revealing a multiple myeloma.

Hamoudi Samia , Achir Safia , Mimouni Safia

Introduction: The sellar plasmacytoma, an exceptional localization that can be solitary or associated with a multiple myeloma. We report the case of a sellar mass wrongly diagnosed as an invasive non-functional pituitary adenoma, the diagnosis was rectified postoperatively by the anatomopathological study.Case description: A 44 year old female patient, with history of cholecystectomy and megaloblastic anemia, was referred to our center for management of ...

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ea0081ep648 | Pituitary and Neuroendocrinology | ECE2022

Medical treatment of active acromegaly - the results from the Croatian Acromegaly Registry

Sambula Lana , Solak Mirsala , Kraljevic Ivana , Popovac Hrvoje , Polovina Tanja Skoric , Zibar Tomšić Karin , Dusek Tina , Balasko Annemarie , Kastelan Darko

Background: The aim of this study was to evaluate the outcomes of medical treatment in patients with active acromegaly.Material and Methods: We performed a retrospective analysis of 163 patients (101 female, age at diagnosis 47.2&pm;13.4 years) treated between 1990 and 2020., of which 53 were on medical treatment (32.5%). Remission rate after pituitary surgery was 66.5% (n=105/158; 5 patients refused surgery). Patients who did not achieve remiss...

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ea0081ep649 | Pituitary and Neuroendocrinology | ECE2022

Lipid accumulation product (LAP) as surrogate marker of fatty liver in patients with Cushing’s disease (CD)

Miljic Dragana , Djurdjevic Sandra Pekic , Doknic Mirjana , Stojanovic Marko , Djurovic Marina Nikolic , Jemuovic Zvezdana , Radovic Sara , Radić Nevena , Petakov Milan

Introduction: The most common etiology of endogenous Cushings syndrome (CS) is Cushings disease (CD). Patients with CS also represent a model of patients with metabolic syndrome (MetS) with associated increased cardiovascular morbidity and mortality. Insulin resistance and obesity, two major characteristics of CS, lead to the accumulation of triglycerides within hepatocytes and formation of fatty liver in these patients.Aim: To evaluate the p...

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ea0081ep650 | Pituitary and Neuroendocrinology | ECE2022

Hypopituitarism in patients with pituitary macroadenomas - the prevalence and prognostic factors

Krivosheeva Yulya , Ilovayskaya Irena

Hypopituitarism due to pituitary lesions may have unclear clinical manifestations, and for its diagnosis it is necessary to conduct a hormonal examination. There are clinical recommendations to conduct a hormonal investigation in all cases of pituitary tumors > 6 mm that seems to be uncertain.The objective to evaluate the frequency of hypopituitarism in patients with pituitary macroadenomas with different hormonal activity and to identify its possibl...

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ea0081ep651 | Pituitary and Neuroendocrinology | ECE2022

Unusual evolution of a non-functionning pituitary adenoma

Hasni Yosra , Arem Marwa El , Elfekih Hamza , saafi wiem , Slimane Abdelhafidh , Maaroufi Amel , Kacem Maha , Chaieb Molka Chadli , Ach Koussay

Introduction: Pituitary neuroendocrine tumors (PitNET) represent 15.5% of primary brain tumors and they can be clinically functioning or non-functioning. Although they are mostly benign, PitNET may be invasive in 30-45% of cases and aggressive in at least 15%. Here, we report the case of a patient who presented a multiple and rapid recurrence of a non-functional pituitary macroadenoma.Observation: A 42-year-old man was admitted initially for headaches, m...

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ea0081ep652 | Pituitary and Neuroendocrinology | ECE2022

Isolated ACTH deficiency with unusual clinical presentation and normal morning cortisol levels

Ibrahim Hassan , Fox Natalie , Bashir Heba , Rathore Ali

A 74-year-old male presented to hospital following an episode of brief loss of consciousness and several hours of post ictal confusion. There was no witnessed seizure activity, tongue biting, or incontinence. His past medical history included SCC right scalp, TIA and primary hypothyroidism. He had been commenced on Cemiplimab (immunotherapy) for metastatic SCC seven months before. On assessment, he appeared well and general examination including neurological examination was no...

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ea0081ep653 | Pituitary and Neuroendocrinology | ECE2022

The impact of Sheehan Syndrome on bone mineral density

Salah Ameni , Maaroufi Amel , Ajili Rihab , Saad Ghada , Hasni Yosra , Ach Koussay

Introduction: Sheehan syndrome (SS), or postpartum pituitary necrosis, is a complete or dissociated adeno-pituitary insufficiency due to hypovolemia secondary to excessive blood loss during or after delivery. Although few studies have investigated osteoporosis in isolated hormone deficiencies, the relationship between SS and osteoporosis has not been investigated in large series of SS. In this study, we aimed to evaluate bone mineral density (BMD) in patients with SS.<p cl...

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ea0081ep654 | Pituitary and Neuroendocrinology | ECE2022

Drug-induced galactorrhea and gynecomastia: a case report

Jurkutė Erika , Masilionis Tomas , Kondrotienė Aistė , Žilaitienė Birutė , Verkauskienė Rasa

Introduction: Finding the cause of gynecomastia and galactorrhea can be challenging, hence one of the most important cornerstones is detailed case history. Hereby we present gynecomastia and galactorrhea case, caused by drug abuse.Case: A 24-year-old male, 3 years suffering from gynecomastia and galactorrhea, came for an endocrinologist consultation in 2020. As known from documentation laboratory blood results, lungs X-ray and abdominal ultrasound did no...

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ea0081ep655 | Pituitary and Neuroendocrinology | ECE2022

Somatostatin analogues in the treatment of a patient with acromegaly - possible positive effects on concomitant epilepsy (a clinical case)

Seferyan Sergey , Zakharova Polina , Ilovayskaya Irena

Somatostatin may act as a neurotransmitter in the neural network. It&grave;s associated with a possible long-term effect on calcium channels and, as a result, on the membrane potential of the cell. Bradycardia due to somatostatin analogues use could be a clinical demonstration of such effect. We would like to present a clinical case of a female patient with acromegaly and possible positive effect of octreotide treatment on concomitant epilepsy. From 2000 (age 40) a woman...

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ea0081ep656 | Pituitary and Neuroendocrinology | ECE2022

Delayed diagnosis of pituitary stalk interruption syndrome in a 26-years-old patient

Abderrahim Yosra , Fadia Boubaker , Charfi Hana , Abid Arige , Mrabet Houcem , Baha Zantour , Lassoued Najoua , Wafa Alaya , Habib Sfar Mohamed

Introduction: Pituitary stalk interruption syndrome (PSIS) is a rare congenital pituitary defect with an estimated incidence of 0.5 per 100,00 births. This syndrome has heterogeneous clinical presentations with varying degrees of pituitary hormones deficiencies. PSIS is commonly diagnosed during neonatal period and infancy. However, when symptoms are not evident or overlooked, the diagnosis could be delayed exposing the patient to acute, such as acute adrenal insufficiency, an...

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ea0081ep657 | Pituitary and Neuroendocrinology | ECE2022

Pathomorphological markers of somatotroph neuroendocrine tumors predicting the treatment outcome in acromegaly

Tomasik Agnieszka , Stelmachowska-Banaś Maria , Maksymowicz Maria , Czajka-Oraniec Izabella , Raczkiewicz Dorota , Zieliński Grzegorz , Kunicki Jacek , Zgliczyński Wojciech

Background: Transsphenoidal adenomectomy of GH-secreting pituitary tumour is a first-line treatment of acromegaly. Pharmacological treatment is recommended if surgery did not lead to disease remission. Pathological assessment of postoperative tissue provides clinicians with valuable information on the disease course.Aim: The aim of this study was to assess whether clinical, imaging, and pathological characteristics can predict surgical remission and resp...

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ea0081ep658 | Pituitary and Neuroendocrinology | ECE2022

Two cases: hemorrhagic rathke cleft cysts mimicking a hemorrhagic adenoma

Sebile Dokmetaş Hatice , Bayramgil Ayberk , Dokmetaş Meric , Kılıclı Fatih , Dorukhan Cavuşoğlu Guneş , Karaipek Ku bra , Gul Yildirim Kizilkaya Ayşe

Introduction: Rathke Cleft Cysts(RCCs) are benign cysts arising from the remnants of Rathkes pouch. The most common symptoms are visual field disorders, headache, and pituitary dysfunction. Case 1: A 26-year-old male was admitted with headache that started 4 days ago. Cranial MRI revealed an appearance mimicking a hemorrhagic adenoma in pituitary. Pituitary hormones were found as normally. Pituitary MRI showed a 12x10x10 mm hemorrhagic RCCs located...

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ea0081ep659 | Pituitary and Neuroendocrinology | ECE2022

Central precocious puberty on pituitary adenoma : about a case report

Rifai Kaoutar , Farah Kamel , Iraqi Hind , Hassan El Gharbi Mohamed

Introduction: Central precocious puberty (CPP) is a frequent reason for consultation in pediatrics. It is defined as the development of sexual characteristics before the age of 8 years in girls and 9 years in boys. Pediatric pituitary adenomas are rare. We report the case of a patient who presented with central precocious puberty on pituitary adenoma.Observation: This is a patient aged 7 years and 6 months, without any particular history, having consulte...

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ea0081ep660 | Pituitary and Neuroendocrinology | ECE2022

Automated data extraction of structured clinical correspondence with SNOMED coding to assess regional epidemiology of common pituitary conditions

Hao Alan Yap Shao , Graveling Alex , Abraham Prakash , Philip Sam

Introduction: Pituitary disorders are associated with increased mortality and morbidity. Data on the prevalence of pituitary disorders is scarce. Formal routine coding of diagnoses in outpatient endocrine practice lags behind medical coding of inpatients. Standardised coding could improve our understanding of disease burden and highlight areas of increasing need within our services.Objective: Automatically extract and assign SNOMED codes for endocrine di...

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ea0081ep661 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly-related cardiovascular morbidity In Tunisian Patients: Prevalence and clinical peculiarities

Akid Faten Haj Kacem , Belabed Wafa , Ahmed Mohamed Abdellahi , Elleuch Mouna , Salah Dhoha Ben , Mnif Fatma , Mejdoub Nabila , Abid Mohamed

Background and Aims: Cardiometabolic comorbidity is a well-established complication related to GH hypersecretion. Several studies have highlighted an increased cardiovascular risk in this population. The objective of the current work was to investigate the cardiovascular complications in Tunisian patients diagnosed with acromegaly.Patients and Method: We conducted a retrospective study that included all patients diagnosed with acromegaly who have been fo...

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ea0081ep662 | Pituitary and Neuroendocrinology | ECE2022

The frequency of water and electrolyte disorders after transnasal surgery for adenomas of the hypothalamic-pituitary region: what does active control of blood sodium level give?

Fargieva Khava , Mikhailova Daria , Ivashenko Oksana , Azizyan Vilen , Grigoriev Andrey , Sergeev Arkadiy , Przhiyalkovskaya Elena , Ekaterina Pigarova , Dzeranova Larisa , Mokrysheva Natalya

Introduction: Water-electrolyte disorders are serious complications after transnasal adenomectomy for formations of the hypothalamic-pituitary region. The purpose of this work was to evaluate the incidence of postoperative hyponatremia in the tactics of active control of sodium levels in the blood.Materials and methods: The study included the results of a dynamic study of blood sodium levels in 53 patients (mean age 46.6 years [min 19; max 68]) with pitu...

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ea0081ep663 | Pituitary and Neuroendocrinology | ECE2022

Hypothalamic syndrome secondary to systemic sarcoidosis

Vicente Gil Boix Jose , Soler Guillermo Serra , Font Mercedes Noval , Cubas Javier Bodoque , Raczkowski Meritxell Vin es , Sanmartin Sanchez Alicia , Tofe Povedano Santiago , Ribas Elena Mena , Marcet Mercedes Codina , Alcolea Josefina Olivares , Palou Francisca Caimari , Macazaga Vicente Pereg , ArguElles Imenez Inaki

Introduction: Sarcoidosis is a rare systemic disease where clusters of immune cells form granulomas in various organs of the body. Its prevalence ranges from 1-40 per 100,000 people in Europe. Neurological involvement of the disease occurs in 5-10% of cases, with the hypothalamus-pituitary gland being one of the most commonly affected structures.Clinical Case: A 36-year-old male with a history of hypertension, obesity, asthma and OSAS. He went to the eme...

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ea0081ep664 | Pituitary and Neuroendocrinology | ECE2022

Peak cortisol level on synacthen stimulation test in cushing’s disease

Ali Rashid Razan , Boot Christopher S , James Andy , Mamoojee Yaasir

Background: Diagnostic work-up for Cushing s syndrome (CS) can be challenging, with variable performance characteristics on screening tests. We were recently referred a young female patient with Cushings disease (CD) due to a microadenoma. She presented with a seizure and initial biochemical work-up included a Synacthen stimulation test (SST). Her peak cortisol rose to over 1,000 nmol/l. Exaggerated response during SST is expected in hyperestrogenic states due to e...

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ea0081ep665 | Pituitary and Neuroendocrinology | ECE2022

Giant prolactinomas: a descriptive study and prognostic analysis

Elleuch Mouna , Frikha Hamdi , Fatma Loukil , Salah Dhoha Ben , Souhir Maalej , Mnif Mouna , Mnif Fatma , Charfi Nadia , Majdoub Nabila Rekik , Akid Faten Haj Kacem , Abid Mohamed

Introduction: Giant prolactinomas (GP), defined as prolactinomas ≥4 cm in maximum dimension, are uncommon, with reported prevalence of 2 to 3% of all prolactinomas. Aim: The aim of this study is to describe clinical and paraclinical characteristics of GP and to identify predictors of therapeutic response.Matherials and methods: A retrospective, single-center, descriptive study including 18 patients with GP followed at the end...

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ea0081ep666 | Pituitary and Neuroendocrinology | ECE2022

Pharmacokinetic profile of cabergoline in patients with dopamine agonist resistant prolactinomas: a pilot study

Shutova Aleksandra , Fedorova Natalia , Vorotnikova Svetlana , Ioutsi Vitalii , Panov Juriy , Pigarova Ekaterina , Dzeranova Larisa , Troshina Ekaterina

Introduction: Approximately 20% of patients with prolactinomas do not respond satisfactory (resistant) even to high dose dopamine agonist treatment. Worth noticing that there are no clear prognostic signs of treatments resistance as well as its etiology is a subject of discussion. Aim: The aim of our study was to assessabsorption and metabolism of cabergoline in patients with dopamine agonist-resistant prolactinomas.Materials...

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ea0081ep667 | Pituitary and Neuroendocrinology | ECE2022

Male pituitary-gonadal axis function in obstructive sleep apnoea syndrome: the effect of continuous positive airway pressure

Leigh Richard , Hamon Siobha n , McWeeney Michael , O'Loughlin Aonghus , O'Shea Paula

Background: Obstructive sleep apnoea syndrome (OSAS) is common; disproportionately affecting the overweight and obese. Continuous positive airway pressure (CPAP) is the first-line treatment for moderate to severe OSAS. Clinical equipoise exists as to whether CPAP treatment directly affects pituitary-gonadal hormone synthesis.Study Aim: This study aimed to determine the effect of CPAP treatment on gonadotropins, prolactin, sex-hormone binding-globulin (SH...

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ea0081ep668 | Pituitary and Neuroendocrinology | ECE2022

A multicenter retrospective study on a large cohort of patients with primary empty sella: hormonal and neuroradiological features over a long follow-up

Carosi Giulia , Brunetti Alessandro , Mangone Alessandra , Baldelli Roberto , Tresoldi Alberto , Sindaco Giulia Del , Lavezzi Elisabetta , Sala Elisa , Mungari Roberta , Fatti Letizia Maria , Galazzi Elena , Ferrante Emanuele , Indirli Rita , Biamonte Emilia , Arosio Maura , Cozzi Renato , Gerardo Antonio Lania Andrea , Mazziotti Gherardo , Mantovani Giovanna

Background: primary empty sella (ES) represents a frequent finding (up to 35% of the general population). According to the literature, the prevalence of hypopituitarism in ES ranges between 19-52%. Data on the natural history of ES over a long time, especially in incidental ES, are still lacking and the management can be challenging.Objective: our primary aim was to assess in a large cohort of patients with ES the prevalence and determinants of hypopitui...

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ea0081ep669 | Pituitary and Neuroendocrinology | ECE2022

Predictors of surgical outcome and early criteria of remission in acromegaly

Astafyeva Ludmila , Shkarubo Alexsey , Sameh R.A. Ibrahim , Badmaeva Inna , Sidneva Yuliya , Strunina Julia , Kutin Maxim , Fomicev Dmitrii , Sharipov Oleg , Andreev Dmitrii , Chernov Ilya , Kalinin Pavel

Objective: To analyze the remission factors of surgical treatment of acromegaly Methods: A retrospective study involving 227 patients with acromegaly: 143 (63%) women and 84 (37%) men were operated via trassphenoidal endoscopic approach for pituitary adenoma removal between the periods of 2018-2021. The average age was 45 years [36.00, 56.00]. 118 patients had 6 months follow-up period (3-40 months). The IGF-1 index used for the evaluation, which was cal...

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ea0081ep670 | Pituitary and Neuroendocrinology | ECE2022

Xantho-granulomatous hypophysitis: analysis of clinical, biochemical, radiological and etiological characteristics

Miljic Dragana , Djurdjevic Sandra Pekic , Doknic Mirjana , Stojanovic Marko , Djurovic Marina Nikolic , Jemuovic Zvezdana , Milojevic Toplica , Milicevic Mihailo , Gacic Emilija Manojlovic , Jovanovic Jovan , Medenica Sanja , Petakov Milan

Introduction: Xanthomatous hypophysitis (XH) is characterized by inflammatory infiltration of the pituitary gland in which lipid laden macrophages predominate. It can be primary (3% of all primary hypophysitis) and secondary arising in the setting of other lesions: craniopharyngioma, Rathkes cleft cyst (RCC), adenomas (with subclinical apoplexy). It is more common in women and younger people. The clinical presentation is similar to pituitary tumors and may prese...

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ea0081ep671 | Pituitary and Neuroendocrinology | ECE2022

The many faces of Granulomatosis with Polyangitis(GPA) presenting with Diabetes Inspidus, visual disturbances, epistaxis and haematuria

Mlawa Gideon , Meneissy Noha , Patel Shrini , Saleem Muhammad , Khan Zahid , Islam Saiful , Gunnell Rachel , Rehmani Hassan , Low Barney , Bashir Mahamud

Introduction: Granulomatosis with polyangiitis (GPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis of both small and medium-sized vessels. Pituitary involvement in GPA is uncommon and few cases have been previously reported. Isolated pituitary involvement in GPA is rare and 96% of cases are associated with other organ involvement. GPA commonly affects the upper respiratory tract (93%), lungs (73%) and kidneys (67%).Case...

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ea0081ep672 | Pituitary and Neuroendocrinology | ECE2022

Service evaluation of endocrine and surgical outcomes post-pituitary surgery for non-functioning pituitary macroadenomas (NFPAs) in a subset of patients

Ikegwu Rosemary , Mathad Nijaguna , Hempenstall Jonathan , Knysak Alicja , Al-Mrayat Ma'en

Background: Non-functioning pituitary adenomas (NFPAs) are the most common pituitary macroadenomas with a prevalence of 7-22 per 100,000 population. As they are non-secretory, they tend to present late with visual disturbances, headaches or hormonal deficiencies. Surgery is the main treatment for NFPAs, particularly endoscopic transsphenoidal surgery which can be associated with surgical and endocrine complications.Aims: To compare pre- and post-operativ...

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ea0081ep673 | Pituitary and Neuroendocrinology | ECE2022

Growth hormone (GH) replacement therapy (GHRT) in patients with adult GH deficiency (AGHD) aged ≥60 years: data from NordiNet® IOS and the ANSWER Program

M. Weber Matthias , B. Gordon Murray , Hoybye Charlotte , H. Olsen Anne , Kelepouris Nicky , Nedjatian Navid , M.K. Biller Beverly

Introduction: There are limited data on the effectiveness and safety of GHRT in older patients with AGHD. We compared real-world GHRT outcomes in older (aged ≥60 years) vs middle-aged (35<60 years) adults.Methods: NordiNet® IOS (NCT00960128) and ANSWER (NCT01009905) were non-interventional studies investigating long-term effectiveness and safety of GHRT with Norditropin® (somatropin, Novo Nordisk). Safety was assessed in the ful...

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ea0081ep674 | Pituitary and Neuroendocrinology | ECE2022

Cushing’s disease and health-related quality of life: a cure for all dimensions?

Duarte Diana Borges , Puga Francisca , Ribeiro Isabel , Amaral Claudia

-Diana Borges Duarte and Francisca Puga are joint first authors and contributed equallyBackground: As therapeutic options improve for Cushings disease (CD), most patients can now achieve control or cure of hypercortisolism. However, persistent complaints are often reported. Evaluation of health-related quality of life (HR-QoL) can highlight impairments beyond the stricter clinical aspects. Our aim was to evaluate HR-QoL with a specific focus on men...

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ea0081ep675 | Pituitary and Neuroendocrinology | ECE2022

Association between acromegaly and papillary thyroid cancer: A case series

Anne-Marie Stefan Andreea , Ioana Dumitriu Roxana , Iulia-Florentina Burcea , Raluca Trifănescu , Niculescu Dan Alexandru , Poiana Catalina

Background: Acromegaly is a rare disorder caused by hypersecretion of growth-hormone (GH) and insulin-like growth factor (IGF-1), the underlying lesion being most frequently a pituitary adenoma. This disease is associated with a higher risk of malignancy. We describe the clinical and biochemical particularities in a series of patients with acromegaly and papillary thyroid carcinoma (PTC).Case study: Out of 311 acromegalic patients, five cases that associ...

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ea0081ep676 | Pituitary and Neuroendocrinology | ECE2022

Idiopathic isolated adrenocorticotropic hormone deficiency

Komzia Paraskevi , Gogakos Apostolos , Kalograni Fanny , Tsoutsas Georgios , Kita Marina , Efstathiadou Zoi

Introduction: Idiopathic Isolated Adrenocorticotropic hormone (ACTH) deficiency (IIAD) is a rare cause of secondary adrenal insufficiency. It can present with a variety of clinical symptoms, mainly chronic fatigue and euvolemic hyponatraemia, and may coexist with autoimmune disease, most commonly Hashimotos thyroiditis. Radiographically, an empty sella turcica image can be seen. We present 3 cases of isolated ACTH deficiency.Case 1: A 47-year-old w...

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ea0081ep677 | Pituitary and Neuroendocrinology | ECE2022

Role of new peptide biomarkers in metabolic profiling of adult growth hormone deficiency patients: preliminary data on neudesin and its relationship with LEAP-2

Vergani Edoardo , Bruno Carmine , Gavotti Cesare , Oliva Alessandro , Curro Diego , Mancini Antonio

Patients affected by adult growth hormone deficiency (aGHD) show worse metabolic profile, with insulin-resistance, increased total cholesterol, LDL, triglycerides, reduced HDL, and higher risk of developing type 2 diabetes mellitus and cardiovascular complications. Adult GHD and metabolic syndrome (MetS) are closely related to each other, since they share the previous depicted clinical features, while obese MetS patients display lower IGF-1 levels due to a functional reduction...

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ea0081ep678 | Pituitary and Neuroendocrinology | ECE2022

Incipient adrenal crisis following ChAdOx1 SARS-CoV-2 vaccination in a patient with undiagnosed isolated adrenocorticotropic hormone deficiency

Thewjitcharoen Yotsapon , Saiwaew Natthakan , Prasartkaew Hussamon , Nakasatien Soontaree , Himathongkam Thep

Background: Isolated adrenocorticotropic hormone (ACTH) deficiency is a rare entity defined by secondary adrenal insufficiency and normal secretion of all other pituitary hormones. Delays in adrenal insufficiency (AI) diagnosis frequently encounter among older patients because of non-specific symptoms. The occurrences of actual or incipient adrenal crises following coronavirus disease 2019 (COVID-19) vaccine administration are increasingly reported over the last year after vac...

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ea0081ep679 | Pituitary and Neuroendocrinology | ECE2022

ACTH-GH pituitary adenoma in an adolescent: a Case Report

Abidi Sahar , Wafa Grira , Khessairi Nadia , Oueslati Ibtissem , Yazidi Meriem , Chaker Fatma , Chihaoui Melika

Plurihormonal pituitary adenomas represent 10-15% of all functioning pituitary adenomas. Functioning ACTH-GH pituitary adenomas constitute an extremely rare entity. Most patients present a clinically manifested acromegaly and subclinical Cushings disease. We present the case of a 14 years old female who referred to the endocrinology department for inaugural diabetic ketosis. She had a six-month history of amenorrhea and headaches. On examination, she had facial dysmporph...

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ea0081ep680 | Pituitary and Neuroendocrinology | ECE2022

Pituitary adenoma associated with intracavernous meningioma: Case report

Lachkhem Aicha , Yahi Abdelkader , Lounes Haffaf , Katia Benabdelatif , Staifi Ahcen , Derradji Hakim , Ourrad Elmountassir , Samia Ould Kablia

Introduction: Pituitary adenoma and meningioma are the most benign tumors in the central nervous system (meningioma 35,9%, pituitary tumor: 15,5%). Pituitary adenoma associated with meningioma without a history of radiotherapy is extremely rare.Case: A 70 years old man operated for post-traumatic subdural hematoma in whom the brain MRI (magnetic resonance imaging) had also shown a macroadenoma, completed with an MRI of the sellar region which were confir...

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ea0081ep681 | Pituitary and Neuroendocrinology | ECE2022

Severe hyponatremia after coronary angiogram - the link between ischemic cardiac disease and hypopituitarism

Ene Cristina , Nour-Dinca Angelica , Bica Dorin , Enyedi Mihaly

Background: Hyponatremia in not uncommon in elderly. Common causes include medication, heart, kidney and liver diseases, digestive loses, syndrome of inappropriate anti-diuretic hormone. Hormonal imbalances are sometimes overlooked. Sudden onset after a recently invasive procedure could challenge the diagnostic.Methods: We present a case report of a severe hyponatremia diagnosed after a coronary angiogram. It is a rare case of hypopituitarism secondary t...

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ea0081ep682 | Pituitary and Neuroendocrinology | ECE2022

A 29 year old woman with aggressive acromegaly as a single manifestation of multiple endocrine neoplasia type 1

Dolores Moure Maria , Catalan Gregorio , Pomposo Inigo , Badiola Miren , Miret Iker , Castano Luis , Gaztambide Sonia

Introduction: Parathyroid tumors are the most common (90%) and usually the first manifestation feature of MEN1 syndrome. The occurrence of anterior pituitary tumors in MEN1 syndrome may range between 10% and 60%. Pituitary involvement includes the initial manifestation of MEN1 syndrome in 10% to 25% of individuals and usually show more aggressive behavior; 20% secrete prolactin, fewer than 10% secrete GH, 5% secrete ACTH, and the remainder appear to ...

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ea0081ep683 | Pituitary and Neuroendocrinology | ECE2022

Pituitary Coma? Discordant pituitary biochemistry after consumption of a commercially available ‘Sleep Activator’.

Phillips Benjamin , Kumar Mohit

We present a case of discordant pituitary biochemistry which resolved after discontinuing a commercially available combination vitamin supplement. A 35 year-old man presented following an episode of headache and dizziness, preceding collapse and possible seizure activity. Investigations revealed deranged pituitary function: TSH 0.02 mU/l (0.35-5.50), fT4 3.6 pmol/l (10.0-20.0), 9 am cortisol 18 nmol/l (200-500), testosterone >52 nmol/l (8.4-28.7), FSH <0.3 U/l (1.0-18....

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ea0081ep684 | Pituitary and Neuroendocrinology | ECE2022

Two case: hemorrhagic rathke cleft cysts mimicking a hemorrhagic adenoma

Sebile Dokmetas H. , Bayramgil Ayberk , Dokmetaş Meric , Kılıclı Fatih , Dorukhan Cavuşoğlu Guneş , Karaipek Ku bra , Gul Yildirim Kizilkaya Ayşe

Introduction: Rathke Cleft Cysts(RCCs) are benign cysts arising from the remnants of Rathkes pouch. The most common symptoms are visual field disorders, headache, and pituitary dysfunction. Case 1: A 26-year-old male was admitted with headache that started 4 days ago. Cranial MRI revealed an appearance mimicking a hemorrhagic adenoma in pituitary. Pituitary hormones were found as normally. Pituitary MRI showed a 12 x 10 x 10 mm hemorrhagic RCCs loc...

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ea0081ep685 | Pituitary and Neuroendocrinology | ECE2022

Ectopic Neurohypophysis

Sebile Dokmetaş Hatice , Dorukhan Cavuşoğlu Guneş , Dokmetaş Meric , Kılıclı Fatih , Bayramgil Ayberk , Karaipek Kubra

Introduction: Ectopic neurohypophysis is a congenital abnormality related to faulty embryogenesis resulting in incomplete caudal extension of the infundibulum. It may present itself with symptoms of growth hormone deficiency or panhypopituitarism and patients require replacement treatment for panhypopituitarism.Case Presentation: Our female patient was shorter (138 cm) than her peers and did not menstruate at the age of 19 when she first...

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ea0081ep686 | Pituitary and Neuroendocrinology | ECE2022

Case report: pituitary macroadenoma with thyroid stimulating hormone (TSH) and growth hormone (GH) co-secretion

Voon Tong Chin , Low Yen Nee , Ooi Eng Hui , Alias Azliana binti

Introduction: The prevalence of pituitary adenoma is estimated to be 17% and about half secrete a distinct hormone. Prolactin secretion is the commonest, followed by GH or adrenocorticotropic hormone (ACTH). TSH producing pituitary adenoma is rare and occurs in less than 1% of pituitary adenomas. We report a challenging case of a 30-year-old man who presented with TSH and GH secreting pituitary macroadenoma with mass effect. Case Report: A 30-year-old ma...

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ea0081ep687 | Pituitary and Neuroendocrinology | ECE2022

Primary Empty Sella Syndrome revealed by a growth retardation : about 14 cases

Faraoun Khadra , Fatiha Mohammedi

Background: Empty sella turcica (EST) is characterized by the passage of cerebrospinal fluid (CSF) into the sella turcica through the sellar diaphragm. The aim of our work is to study the clinical and hormonal characteristics of patients with EST discovered due to height delay.Patients and methods: Descriptive study on 14 patient files. Data studied : history, anthropometry, endocrine deficits and associated pathologies.Results/Dis...

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ea0081ep688 | Pituitary and Neuroendocrinology | ECE2022

Rupture of the pituitary stalk : clinical, para-clinical and evolutionary aspects of 9 patients followed in the Endocrinology department, Oran University Hospital.

Faraoun Khadra , Fatiha Mohammedi

Background: The non-traumatic pituitary stalk interruption syndrome described after the advent of MRI is a congenital pituitary abnormality, often responsible for pituitary insufficiency revealed during the neonatal period. We note 9 cases of late diagnostic during the exploration of growth retardation.Patients and methods: Descriptive cross-sectional study on files of 9 patients, 5 boys and 4 girls with an average age of 10.5 years (range 3 and 18 years...

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ea0081ep689 | Pituitary and Neuroendocrinology | ECE2022

Hypopituitarism caused by intravascular large B cell lymphoma (IVLBCL)

Vashakmadze Natia

Intravascular Large B-Cell lymphoma (IVLBCL) is an extremely rare type of non-Hodgkin lymphoma involving the growth of lymphoma cells within the vessel lumen without lymphadenopathy. As disease has various modes of presentation and is exceptionally rare, IVLBCL is often diagnosed postmortem. Herein, we report a case of IVLBCL with hypopituitarism, an extremely rare complication, that was successfully treated with chemotherapy. 60 years old woman noticed redness of the abdomen,...

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ea0081ep690 | Pituitary and Neuroendocrinology | ECE2022

Complete remision of nelson´s syndrome with cabergoline treatment

Egana Zunzunegui Nerea , Ortega Cristina Elias , Nebreda Inmaculada Venegas , Achucarro Ane Amilibia , Garay Ismene Bilbao , Calafell Maite Aramburu , Delgado Cristina Garcia , Arrieta Alfredo Yoldi

Introduction: Nelson´s Syndrome is defined as the presence of an enlarging pituitary tumor associated with elevated fasting plasma ACTH levels and hyperpigmentation in patients submitted to bilateral adrenalectomy for the treatment of Cushing´s disease. Case Report: We present a case of a 48 y/o woman who in 2015, was diagnosed of Cushings disease and underwent transsphenoidal adenomectomy but remission was not achieved, so the patient wa...

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ea0081ep691 | Pituitary and Neuroendocrinology | ECE2022

Genomic and epigenomic aspects of Aspirin antitumoral effect in pituitary adenoma

Szabo Borbala , Krokker Lilla , Meszaros Katalin , Saskői Eva , Nemeth Krisztina , Szabo Pal , Szucs Nikolette , Czirjak Sandor , Patocs Attila , Butz Henriett

Background: In our previous works the interdependence of DNA demethylation with proliferation and differentiation of pituitary neuroendocrine tumours (PitNET) and the inhibitory effect of Aspirin on pituitary cell proliferation were demonstrated. Although the role of Aspirin in epigenetic regulation was described in other malignancies, its correlation with pituitary tumorigenesis is currently unknown.Our objective: was to investigate the genomic and epig...

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ea0081ep692 | Pituitary and Neuroendocrinology | ECE2022

Soluble alpha klotho in blood is a new and highly stable biomarker

Ribeiro de Oliveira Longo Schweizer Junia , Haenelt Michael , Schilbach Katharina , Stormann Sylvere , Schopohl Jochen , Bidlingmaier Martin

Background: Soluble alpha klotho (sαKL) is a circulating protein that has been linked to the growth hormone (GH) axis. We previously showed its association to disease activity in patients with acromegaly, with considerable robustness towards biological confounders. However, there is scarce data in literature regarding the analytical performance of the assay, and pre-analytical stability of sαKL in blood samples. Objective: We aimed to evaluate ...

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ea0081ep693 | Pituitary and Neuroendocrinology | ECE2022

Influence of Desmopressin treatment in patients undergoing surgery for cushing’s disease

Moreno-Moreno Paloma , Rebollo-Roman Angel , Leon-Idougourram Soraya , Teomiro Carlos Manuel Alza s , Angeles Galvez-Moreno Maria

Objective: ACTH-secreting pituitary tumors (ACTHomas) express vasopressin (AVP) receptors. AVP receptors are also present in other types of cancer, exerting different effects on tumor growth depending on the receptor subtype. AVP type 1 receptors (V1a and V1b) are associated with stimulation of cell proliferation, AVP receptor type 2 (V2r) is associated with antiproliferative effects. Desmopressin (DAVP) is a synthetic analog of AVP that acts as a selective agonist for V2r, wh...

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ea0081ep694 | Pituitary and Neuroendocrinology | ECE2022

Evaluation of the effectiveness of patients with acromegaly treatment (according to the moscow register)

Antsiferov Mikhail , Alekseeva Tatiana , Pronin Evgenii , Ionova Olga , Goldman Elena , Orlova Ekaterina , Matosyan Karina

The aim: To determine the prognostic parameters affecting the course of acromegaly (A.) and the effectiveness of drug therapy (MT).Matherials and methods: 779 patients of A. [218 men (28%)] aged 60 (48/69) years, [Me(25%/75%)] were included in the Moscow register. The prevalence of A. in Moscow is 61.6; the incidence is 4.0 cases/million inhabitants. The treatment algorithm included surgical aid (495 patients), primary (I) or secondary (II) MT (584) and ...

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ea0081ep695 | Pituitary and Neuroendocrinology | ECE2022

Epidemiological description of 20 years of experience in the management of insulinomas in a third level hospital

Maricel Rivas Montenegro Alejandra , Ramos Roberto Jose An ez , Belinchon Sergio Santos , Gonzalez Fernandez Laura , Moreno Diego Mun oz , Fernandez Fernandez Elisa , Salas Marcel Sambo , Hualpa Juan Carlos Percovich , Gonzalez Albarran Olga , Garcia Centeno Rogelio

Introduction: Insulinoma, despite its low incidence of 0.4%, it is the most common functioning pancreatic neuroendocrine tumor. Most are benign, solitary and sporadic. Around 10% can be malignant and 5-10% are part of MEN-1. On certain occasions, the differential diagnosis is difficult when there is a history of Diabetes Mellitus (DM). Our objective was to describe clinical-epidemiological data and its diagnostic-therapeutic management.Materials and Meth...

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ea0081ep696 | Pituitary and Neuroendocrinology | ECE2022

AQP2 gene mutation C.450T>A in a Tunisian family

Mnif Fatma , Charfi Hana , Abdelhedi Fatma , Bouassida Malek , Akid Faten Haj Kacem , Salah Dhoha Ben , Mnif Mouna , Charfi Nadia , MAJDOUB NABILA REKIK , Elleuch Mouna , Kammoun Hassen , Abid Mohamed

Introduction: The nephrogenic diabetes insipidus (DI) is an entity to be known. It is essential to know its etiologies and especially its therapeutic modalities which are different from those of the central DI. The familial nature of the disease should suggest a genetic origin. In our paper, we are presenting the case of a Tunisian family with genetic nephrogenic DI.Case reports: Our family had a history of neglected polyuro-polydipsic syndrome (PPS), de...

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ea0081ep697 | Pituitary and Neuroendocrinology | ECE2022

Endocrine dysfunction secondary to pituitary tuberculoma: a case report

Mnif Fatma , Charfi Hana , Salah Dhoha Ben , Akid Faten Haj Kacem , Charfi Nadia , Majdoub Nabila Rekik , Mnif Mouna , Elleuch Mouna , Abid Mohamed

Introduction: Tuberculosis is an infectious disease that involves any organ. However, the primary pituitary tuberculosis is an extremely rare disease. Intracranial tuberculomas account for 0,15-5% of intracranial space-occupying lesions, of which pituitary as the primary site, and easily misdiagnosed as pituitary adenoma. In this setting, the late diagnosis can result in permanent endocrine dysfunction. We hereby report the case of a patient with pituita...

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ea0081ep698 | Pituitary and Neuroendocrinology | ECE2022

Age and puberty based IGF-1 normative data in healthy children from North India.

Malhotra Bhanu , Teja Kv Ravi , Bhadada Sanjay , Rastogi Ashu , Bhansali Anil , Sachdeva Naresh , Minz Ranjana Walker , Walia Rama , Prakash Mahesh , Aggarwal Arun Kumar , Dewan Gajinder , Das Liza , Monaghan Philip , Trainer Peter , Korbonits Marta , Marwaha Raman Kumar , Dutta Pinaki

Context: Serum IGF-1 levels are of paramount importance for diagnosis and management of growth related disorders. The reference range of IGF- 1 should be ethnicity and Tanner specific. Indian data on the same is scarce and there is a need to develop the same.Objective: To develop age, sex and Tanner based normative reference range of serum IGF-1 level for Indian children and correlate the same with peri-pubertal hormonal parameters.<p class="abstext"...

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ea0081ep699 | Pituitary and Neuroendocrinology | ECE2022

Pituitary adenomas characteristics in patients with multiple endocrine neoplasia type 1, its phenocopies and sporadic acromegaly

Trukhina Diana , Mamedova Elizaveta , Lapshina Anastasia , Nikitin Alexey , Koshkin Philipp , Azizyan Vilen , Grigoriev Andrey , Belaya Zhanna , Melnichenko Galina

Multiple endocrine neoplasia type 1(MEN1) is a hereditary condition caused by mutations in the MEN1 gene, which encodes menin protein. The syndrome predisposes to the development of tumors in both endocrine and non-endocrine systems. In patients with MEN1, pituitary adenomas (PA) occur in approximately 40% of all cases. If patient has MEN1 phenotype with no mutations in MEN1 gene, the condition is regarded as a phenocopy. The reason of several endocrine MEN1-...

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ea0081ep700 | Pituitary and Neuroendocrinology | ECE2022

A Delphi panel of Italian endocrinologists to define the unmet needs on the current management of Cushing’s Syndrome

Pivonello Rosario , Carla Scaroni , Polistena Barbara , Migliore Antonio , Giustina Andrea

Introduction: Cushings Syndrome (CS) requires an accurate diagnosis, patient-tailored treatments and long-term management. To define the unmet needs of patients with CS, a consensus among a panel of Italian endocrinologists was promoted. The panel involved 57 specialists with expertise in CS management.Methods: The endocrinologists were identified by convenience sampling. The survey was built around a set of statements formulated after literature r...

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ea0081ep701 | Pituitary and Neuroendocrinology | ECE2022

Age at the diagnosis or age at the onset of symptoms- which should be taken into consideration in patients with early-onset acromegaly- pilot study

Godlewska Magdalena , Bogusławska Anna , Kluczyński Łukasz , Rzepka Ewelina , Hubalewska-Dydejczyk Alicja , Gilis-Januszewska Aleksandra

Introduction: The group of young adults with acromegaly, despite initial reports about their aggressive course of disease, has not been thoroughly characterized. Aim: Our aim was to investigate the differences between the patients with early-onset acromegaly and with onset in older age. Material and methods: Consecutive patients diagnosed with acromegaly between 01.2014 and 12.2021 were included in this retrospective study, approve...

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ea0081ep702 | Pituitary and Neuroendocrinology | ECE2022

Giant pituitary adenomas in children and adolescents: clinical presentation, management and long-term outcome

Giuffrida Giuseppe , giovinazzo salvatore , Alessi Ylenia , Ragonese Marta , Cotta Oana Ruxandra , Angileri Filippo Flavio , Ferrau Francesco , Cannavo Salvatore

Background: Pituitary adenomas in children/adolescents represent around 3% of all intracranial neoplasms. They are more frequently hormone-secreting lesions, usually diagnosed in early childhood and late adolescence. Female gender is generally prevalent, because of most evident symptoms (i.e., irregular periods, galactorrhea, etc.). Giant pituitary adenomas (GA) very rarely occur in pediatric age, posing frequent challenges in their management.Patients a...

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ea0081ep703 | Pituitary and Neuroendocrinology | ECE2022

The clinical implication of macroprolactinemia detection using PEG 6000 in a group of women of childbearing-age with hyperprolactinemia in sub-Saharan Africa: experience of a tertiary hospital

Ongmeb Boli Anne , Francine Mendane Ekobena , Martine Etoa Etoga , FEUTSEU Charly , Samba Esther Aristide Mbono , Amazia Falmata , Eric Noel Djahmeni , Arnaud Ndi Manga , Claude Katte Jean , Mesmin Dehayem , Jocelyne Ama Moor Vicky , Eugene Sobngwi

Introduction: Macroprolactin (MacroPRL), a variant of human prolactin may interfere with hormonal assay and falsely increase serum prolactin levels. Therefore, failure to identify macroprolactinemia can lead to inappropriate investigations and treatment in women who are already susceptible to anxiety and stress. We aimed to identify macroprolactinemia among women of childbearing age with hyperprolactinemia.Materials and methods: We conducted a cross-sect...

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ea0081ep704 | Pituitary and Neuroendocrinology | ECE2022

Cessation of GH secretion in acromegaly without medical or surgical intervetion; Covid-postponed surgery was escaped

Erdei Annamaria , Daniel Eszter , Gazdag Annamaria , Griger Miha ly , Nagy Edit B , Nagy Endre V

Introduction: Acromegaly is usually caused by pituitary macroadenoma producing excess growth hormone. Treatment options include surgery to remove the tumor, medications, and radiation therapy.Case report: A 39-year-old woman has been referred to the endocrine clinic with suspected acromegaly in December 2019. Surgery for benign ovarian cyst, endometriosis, amenorrhoea, unsuccessful in vitro fertilisations were present in her medical history. She complain...

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ea0081ep705 | Pituitary and Neuroendocrinology | ECE2022

When we count Ki67 in a gonadotropinoma- matters- case report

Costache Outas Mariana

We report the case of a 49 y.o male with an incidental sphenoidal-sellar tumour discovered during a cerebral CT scan during the workup of a medium to severe SARS COV 2 infection. The cerebral MRI describes an invasive tumour located in the sellar region and sphenoidal sinus extended around the right optic nerve and into both cavernous sinuses. An emergency biopsy from the sphenoidal extension of the tumour revealed a neuroendocrine tumour. The reported diagnostic was ol...

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ea0081ep706 | Pituitary and Neuroendocrinology | ECE2022

The septo-optic dysplasia associated with adipsic hypernatremia

Mezoued Mouna , Amine Habouchi , Khadidja Bessaid , Azzouz Malha

Introduction: SOD is a rare congenital anomaly, with an incidence of 1 in 10 000 live births, the adipsic hypernatremia is a rare osmoregulation Disorder observed in SOD.Case report: We report a case of a 28 months infant, the eldest of a sibling group of 2 children, referred by the pediatrician for exploration of a staturo-ponderal delay. At clinical examination we found a harmonious staturo-ponderal delay and a median line anomaly of development a...

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ea0081ep707 | Pituitary and Neuroendocrinology | ECE2022

Hyperprolactinemia and connective tissue diseases: which significance of such exceptional association?

Yahyaoui Arij Ezzouhour , Kefi Asma , Abdelghani Khaoula Ben , Euch Mounira El , Sassi Syrine , Turki Sami , Abderrahim Ezzeddine

Introduction: Dermatomyositis is a chronic, idiopathic inflammatory myopathy that can overlap with rheumatoid arthritis. The immunostimulatory effect of prolactin is suggested by many authors. Herein we report an original association of hyperprolactinemia with a scarce condition: dermatomyositis-rheumatoid arthritis overlap in a young woman. Case description: A 26-year-old woman with no significant medical history was referred to our department to invest...

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ea0081ep708 | Pituitary and Neuroendocrinology | ECE2022

A Rare Case of Isolated ACTH deficiency, Possible cause: long-term use of opioid analgesics for severe Migraine management/Opioid-induced adrenal insufficiency (OIAI) (?)

Zavrashvili Nino , Chanturishvili Ketevan , Gvazava Ketevan , Margvelashvili Natia , Shonia Natia

Context: Hypothalamic-pituitary-adrenal axis (HPA) may be disrupted by drugs, including opioids. Opioids are widely used for treatment of acute and chronic pain, but they also carry a wide range of adverse effects. Opioid receptors are present in the pituitary gland and hypothalamus and chronic use of opioids may lead to adrenal insufficiency because of central suppression of the hypothalamic-pituitary-adrenal axis (HPA).Case Presentation: We report a 26...

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ea0081ep709 | Pituitary and Neuroendocrinology | ECE2022

A rare association of Neurofibromatosis type 2 and hypopituitarism

Ghram Lina , Gharbi Radhouen , Essayeh Sawsen , KANDARA Hajer , Jemel Manel , KAMMOUN Ines

Introduction: Neurofibromatosis type 2 (NF2) is an autosomal dominant genetic disorder that cause a growth of noncancerous tumors in the nervous system, it associates cranial schwannomas, meningiomas, and skin and ophthalmologic lesions. It is a rare condition and its association with an intrasellar arachnoidocele has not been reported yet. We report the case of a patient who presents a NF2 associated with hypopituitarism related to an intrasellar arachnoidocele.<p class="...

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ea0081ep710 | Pituitary and Neuroendocrinology | ECE2022

Langerhans cell histiocytosis revealed by an isolated central diabetes insipidus in an adult

Chaima Halladja , Achir Safia , Belheddad Zina , MIMOUNI SAFIA

Introduction: Langerhans cell histiocytosis (LCH) is a systemic disorder characterized by clonal proliferation of immature dendritic cells observed mainly in children. The affection of the sellar region in adults with central diabetes insipidus as the first manifestation of the disease is extremely rare creating a problem of etiological diagnosis especially when central diabetes insipidus (CDI) is apparently isolated.Case description: A 21-year-old man w...

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ea0081ep711 | Pituitary and Neuroendocrinology | ECE2022

Pituitary adenoma in the young adult

Zarraa Lamiae , Wahiba Abdellaoui , Assarrar Imane , Rouf Siham , Latrech Hanane

Introduction & Background: Pituitary adenomas represent 10-25% of all intracranial tumors. Their incidence is higher between the ages of 40-60 years and less frequent in young adults. The objective of this work was to evaluate the prevalence as well as the clinical and etiological profile of pituitary adenomas in young adults.Key words : pituitary adenoma- yount adult.Material and methods: Retrospective descriptive study of 21 ...

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ea0081ep712 | Pituitary and Neuroendocrinology | ECE2022

Evolution from recurrent cushing’s disease to pituitary carcinoma

Anisia Miruna , Dumitru Teodora , Stoica Alexandra , Ungureanu Maria Christina , Preda Cristina , Rotariu Daniel , Leustean Letitia

Introduction: ACTH-secreting pituitary adenomas occasionally present as aggressive pituitary tumors (APT), with invasion of surrounding structures, rapid growth, resistance to conventional therapies and multiple recurrences. In rare cases they can progress to pituitary carcinomas (PC) in several years, diagnosis being made upon the documentation of systemic or central nervous system (CNS) metastatic spread. Among pituitary carcinomas, the most common malignant subtypes are lac...

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ea0081ep713 | Pituitary and Neuroendocrinology | ECE2022

Bronchial carcinoma as debut in MEN-1 Syndrome

Justel Enriquez Alicia , Torcal Carolina Knott , Blanco Sara Jime nez , Moreno Victor Navas , Marazuela Monica

Background: Neuroendocrine tumors present in the MEN-1 syndrome are usually located in pancreatic islets and more than 10% appear de novo, affecting any age group. The debut of a carcinoid tumor is rare, with a prevalence of 2% of bronchial carcinoid tumors. Materials and methods: We present the case of a 49-year-old woman referred from the Oncology clinic for the assessment of thyroid incidentalomas found in a follow-up CT scan of multifocal bronchial c...

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ea0081ep714 | Pituitary and Neuroendocrinology | ECE2022

Block and replacement therapy of a patient with Cushing’s disease and aggressive complications: a case report

Tănasie Denisa-Isabella , Simona Andreea Găloiu , Caragheorgheopol Andra , Corneci Cristina , Baloseanu Nicoleta , Poiana Catalina

Introduction: We describe a patient with Cushings disease caused by a pituitary macroadenoma treated by double transsphenoidal surgery, stereotactic radiosurgery and steroidogenesis inhibitors and also the challenging management of a patient with multiple comorbidities, including chronic leg ulcers, which are related to increased morbidity and health costs.Case report: In October 2019, a 67-year-old patient presented with intense headache, left tem...

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ea0081ep715 | Pituitary and Neuroendocrinology | ECE2022

Growth hormone leading to faster recovery in pure motor Guillain-Barre syndrome: report of the first off-label use in one patient

Amereller Felix , Jochen Schopohl , Sylvere Stormann , Martin Bidlingmaier , Peter Rieckmann , Philipp Gulde

Background: Although the prognosis inGuillain-Barré syndrome (GBS) is generally good, the protracted and sometimes incomplete recovery is a heavy burden for patients. Animal studies suggest that treatment with growth hormone (GH) could stimulate myelin repair and thus accelerate functional recovery in acute polyneuropathy. We report on the first use of GH in GBS.Objective: To monitor safety and tolerability as well as to evaluate the effect of off-l...

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ea0081ep716 | Pituitary and Neuroendocrinology | ECE2022

Pituitary Hyperplasia secondary to Severe Primary Hypothyroidism

Esdaile Harriet , Alameri Majid , Alnuaimi Abdulla , Martin Niamh , Meeran Karim

Introduction: Thyrotroph pituitary hyperplasia in context of severe primary hypothyroidism is rare and usually occurs due to loss of thyroxine feedback inhibition and overproduction of thyrotropin-releasing hormone, leading to pituitary gland enlargement. Pituitary hyperplasia caused by primary hypothyroidism responds well to thyroid hormone replacement therapy and rarely requires surgical intervention. Case presentation: A 42-year-old female with backgr...

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ea0081ep717 | Pituitary and Neuroendocrinology | ECE2022

An aggressive macroprolactinoma in young boy about a case.

Ludwine Bifoume Ndong Charlene , Jaafari Fatima Zahra El , Rafi Sana , Mghari Ghizlane El , Ansari Nawal El

Introduction: Pituitary adenomas are a rare condition in children and young people. The prolactinoma represents the most frequent of them. We report a case of an atypically evolution of aggressive macroprolactinoma in young patient.Case: Its about a boy of 14 years old with previous history of headache from 5 years without visual disturbance. He was admitted for intracranial hypertension syndrome. In clinical examination no dysmorphic syndrome, a g...

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ea0081ep718 | Pituitary and Neuroendocrinology | ECE2022

Abstract Withdrawn...

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ea0081ep719 | Pituitary and Neuroendocrinology | ECE2022

FSH- secreting pituitary microadenoma and ovarian hyperstimulation

Andrei Marian , Cima Luminita Nicoleta , Tarna Mihaela , Iliescu Marina , Simona Fica

Introduction: The prevalence of functioning gonadotropinoma is difficult to assess since most of reports are case reports. Gonadotropinomas rarely lead to a noticeable clinical syndrome. They usually produce symptoms associated with mass effect such as headaches, visual field impairment and hormonal deficiencies.Case report: We present the case of a 38 years old women diagnosed in 2017 with microprolactinoma. She had elevated prolactin level (108 ng/ml) ...

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ea0081ep720 | Pituitary and Neuroendocrinology | ECE2022

Clinical and laboratory features and management of pituitary apoplexy: Case series

Ozer Ozge , Kebapci Medine Nur , Akalın Aysen , Efe Belgin , Yorulmaz Goknur

Introduction: Pituitary apoplexy (PA) is a clinical emergency resulting from acute ischemia or bleeding of the pituitary gland. Complaints of patients are usuallay headache and vision problems. We tried to discuss the reasons for presentation, pituitary imaging and hormones of patients.Patients and Methods: 10 patients (5 men and 5 women), median age 53 years at diagnosis were retrospectively reviewed. FSH, LH, estradiol/testosterone, GH, IGF1, TSH, FT4,...

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ea0081ep721 | Pituitary and Neuroendocrinology | ECE2022

A case of pituitary hyperplasia in a patient with neurofibromatosis type 1.

Cherchir Faten , Oueslati Ibtissem , Yazidi Meriem , Chihaoui Melika

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with diverse manifestations. Patients with NF1 are particularly prone to developing tumors of the central nervous system (CNS) and endocrine disorders. Herein we report a case of pituitary hyperplasia in a woman with NF1.Observation: A 55-year-old woman was referred to our department for the exploration of recurrent hypoglycemia. Her past medical history included NF1, asthma t...

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ea0081ep722 | Pituitary and Neuroendocrinology | ECE2022

Assessment of the thyroid status in acromegaly patients

Yuksel Bahar Gokce Sezgin , Yorulmaz Goknur , Kalkan Ahmet Toygar , Kebapci Medine Nur , Akalin Aysen , Efe Belgin

Acromegaly is a rare disease associated with hypersecretion of growth hormone due to adenoma of somatotroph cells in the pituitary gland, with elevated morbidity and mortality. Acromegaly and thyroid diseases show high co-occurrence. In our study; we aimed to determine the relationship between disease activity at the time of admission and after treatment with the presence of goiter, presence of nodules, and possible accompanying thyroid malignancy in 119 patients with acromega...

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ea0081ep723 | Pituitary and Neuroendocrinology | ECE2022

Digestive complications of acromegaly : about 40 cases

Rihab Ajili , Ameni Salah , Yosra Hasni , Baha Zantour , Habib Sfar , Koussay Ach

Introduction: Acromegaly is a rare hormonal condition that results from an excess amount of growth hormone (GH) in the body. A variety of complications have been reported in patients with acromegaly including cardiovascular diseases, diabetes mellitus or respiratory disorders. In addition, Acromegaly is associated with gastrointestinal complications. The aim of this study was to evaluate gastrointestinal complications and their impact on the quality of life among patients suff...

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ea0081ep724 | Pituitary and Neuroendocrinology | ECE2022

Short-term and long-term surgical remission of acromegaly in a tertiary medical center

Lutsenko Alexander , Belaya Zhanna , Przhiyalkovskaya Elena , Rozhinskaya Liudmila , Grigoriev Andrey , Azizyan Vilen , Melnichenko Galina

Background: Surgical outcomes in patients with acromegaly are highly dependent on a surgeons level of expertise, as the majority of patients present with macroadenomas at diagnosis.Aim: To assess remission rates in patients with acromegaly admitted to a tertiary medical center.Materials and methods: We included patients admitted to the neuroendocrinology and bone disease department with no previous radiation therapy or curren...

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ea0081ep725 | Pituitary and Neuroendocrinology | ECE2022

Decreased quality of life in adult patients with sheehan syndrome

Salah Ameni , Maaroufi Amel , Ajili Rihab , Saad Ghada , Hasni Yosra , Ach Koussay

Introduction: Sheehan Syndrome (SS) is the oldest known cause of non-tumor acquired anterior pituitary insufficiency in women. The incidence of SS would probably have decreased in recent decades in developed countries thanks to the development of obstetric care. However, it still remains a public health problem in developing countries. In addition, it constitutes a chronic disabling pathology and is strongly linked to an alteration of the quality of life. In this study we aime...

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ea0081ep726 | Pituitary and Neuroendocrinology | ECE2022

Predictive factors of biological remission in patients with prolactinoma treated with dopamine agonists

Elleuch Mouna , Frikha Hamdi , Fatma Loukil , Salah Dhoha Ben , Souissi Matiem , Mnif Fatma , Mnif Mouna , Charfi Nadia , Majdoub Nabila Rekik , Akid Faten Haj Kacem , Abid Mohamed

Introduction and aim: Dopamine agonists (DA) are prescribed as first-line treatment for prolactinomas and are generally effective and well tolerated. However, the degree and quickness of therapeutic response is variable among patients. The aim of this work is to study the predictive factors of biological remission in patients with prolactinoma treated with DA. Methods: A single-center, retrospective and analytical study of patients with prolactinoma foll...

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ea0081ep727 | Pituitary and Neuroendocrinology | ECE2022

Challenging management of giant prolactinomas in men: from efficient small dose of cabergoline to SSA, neurosurgery and Temozolomide

Gilis-Januszewska Aleksandra , Bogusławska Anna , Godlewska Magdalena , Kluczyński Łukasz , Hubalewska-Dydejczyk Alicja

Giant prolactinomas are very rare and constitute 2-3% of all lactotroph PitNETs with male preponderance. We present a case series of five male patients with giant prolactinomas with various clinical presentation. Case 1: A 66-year-old male hospitalized due to left peripheral facial palsy. In computer tomography (CT) pituitary mass (41 x 43 x 64 mm) invading cavernous/sphenoid sinuses/carotid arteries/optic chiasm was visualized. Bitemporal hemianopia/hea...

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ea0081ep728 | Pituitary and Neuroendocrinology | ECE2022

The incidence of hyperprolactinemia in patients with breast cancer.

Khalimova Zamira , Gumarova Aliya

Objectives: To study the relationship between hyperprolactinemia and various forms of breast cancer in women of fertile age.Methods and materials: The study included 100 breast cancer patients, aged 25 to 43 years (mean age 34.5 &pm; 1.4 years). The patients were divided into 2 groups: Group I 33 patients with hyperprolactinemia, which corresponded to 33%. Group II 67 patients with breast cancer without hyperprolactinemia, which corresponded to 67%. Clin...

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ea0081ep729 | Pituitary and Neuroendocrinology | ECE2022

Case report: a challenging gastrinoma in a patient with renal cell carcinoma

Ioana Paduraru Alina , Burcea Iulia Florentina , Poiana Catalina

Introduction: Gastrinomas are rare neuroendocrine tumours (NETs) that arise from enterochromaffin-like cells and produce gastrin. Most are discovered in the duodenum and pancreas. The clear cell type of renal cell carcinoma (RCC) is known for the expression of gastrin-releasing peptide receptor (GRP-R) and some studies have shown GRP can stimulate tumor cell proliferation and neoangiogenesis. Therefore, we present a case with metachronous development of renal cell carcinoma an...

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ea0081ep730 | Pituitary and Neuroendocrinology | ECE2022

Hypogonatropic hypogonadism with craniopharyngioma in adults before and after surgery.

Klockova Irina , Astafieva Ludmila , Kalinin Pavel , Kutin Maksim , Konovalov Aleksandr

Craniopharyngiomas (CF) - a benign tumor of the embryologic origin. The surgical method of treatment is the basic.Objective: to estimate incidence of hypogonatropic hypogonadism before and after surgical treatment of CF at different topographical variations, and after the preservation of the pituitary stalk. Methods: The research involved 79 patients older than 18 years (41 women and 38 men) with a mean age - 40 [17; 69] with a ver...

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ea0081ep731 | Pituitary and Neuroendocrinology | ECE2022

Antioxidant and protective effect of estradiol in liver functions of aged female rats

Kumar Pardeep , Baquer Najma

Background: The objective of this study was to observe the changes in activity of antioxidant enzymes, hepatic glucose homeostasis, lipogenic enzymes and lipid metabolism, serum lipid profile and liver function occurring in livers of female rats of 3, 12 and 24 months age groups, and to see whether these changes are restored to 3 months control levels rats after exogenous administration of steroid hormone estrogens (17-β-estradiol, E2).Methods: The ...

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ea0081ep732 | Pituitary and Neuroendocrinology | ECE2022

Rare case of cushing with papillary thyroid cancer

Fathy Marwa , Hassan Farouk , Salam Randa

Introduction: Papillary thyroid carcinoma is the most common type of thyroid cancer (70-80% of all thyroid cancer). It is a differentiated type of carcinoma, it affects women between 30-60 years old, 3 times more often than males. Clinical outcome in patients with differentiated thyroid carcinoma is often favorable. Glucocorticoids (GC) play major role in the physiologic stress response. However chronic exposure to glucocorticoids as seen in Cushings disease (CD) has det...

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ea0081ep733 | Pituitary and Neuroendocrinology | ECE2022

Analysis of the causes and frequency of discrepancies between GH and IGF-1 levels in patients with acromegaly based on the polish register of acromegaly patients

Ostrowska Magdalena , Tomasik Agnieszka , Zgliczyński Wojciech , Glinicki Piotr

Introduction: Acromegaly is a rare disease of the pituitary gland. Both GH and IGF-1 levels are of key importance for monitoring of treatment effects in patients with acromegaly. In some patients, divergent results of measurements of these hormones are observed. Purpose: The purpose of the study was to estimate frequency of GH and IGF-1 inconsistencies in the population of patients with acromegaly included in the Polish Register of Acromegaly Patients, a...

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ea0081ep734 | Pituitary and Neuroendocrinology | ECE2022

Metabolic and inflammatory parameters for baseline characterization and treatment outcome of prolactinoma patients

Hofbauer Susanna , Ernst Matthias , Horka Laura , Seidenberg Samuel , Regli Lucas , Serra Carlo , Beuschlein Felix , Erlic Zoran

Background: Prolactinomas (PRL) are pituitary adenomas mainly characterized by hyperprolactinemia. In addition to the endocrine effects of prolactin, metabolic alterations have been described in PRL patients. Changes in inflammatory parameters have recently been identified in pituitary adenoma patients. Since both, metabolic (MM) and inflammatory markers (IM) showed promising results in characterization/prognosis of tumor patients, it is tempting to speculate whether those mig...

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ea0081ep735 | Pituitary and Neuroendocrinology | ECE2022

Endocrine treatment of anabolic-androgenic steroid induced hypogonadism in males: A pilot study

Christian Bordado Henriksen Hans , Palmstrom Jorgensen Anders , Bjornebekk Astrid , Neupane Sudan Prasad , A. Havnes Ingrid

Background and aims: Non-prescribed use of anabolic-androgenic steroids (AAS) is associated with a wide range of health risks including AAS-induced hypogonadism (ASIH) caused by negative feedback suppression on the hypothalamic-pituitary-gonadal (HPG) axis. Testicular function might be reduced for months up to years after AAS-cessation, increasing the risk of developing fatigue, decreased libido, erectile dysfunction, infertility, sleep disorder, depression and anxiety. There ...

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ea0081ep736 | Pituitary and Neuroendocrinology | ECE2022

MRI intensity and pituitary volume predict adult-onset growth hormone deficiency in patients with obesity and overweight: a new potential tool guiding subsequent diagnostic testing

Masi Davide , Risi Renata , Balena Angela , Caputi Alessandra , Spoltore Maria Elena , Rossetti Rebecca , Watanabe Mikiko , Tozzi Rossella , Gangitano Elena , Curreli Mariaignazia , Mariani Stefania , Lenzi Andrea , Gnessi Lucio , Lubrano Carla

Background: Reduced growth hormone (GH) secretory capacity is common in patients with obesity and metabolic derangements. The prevalence of GH deficiency (GHD) in this population is difficult to establish. Magnetic Resonance Imaging (MRI) pituitary findings may reflect specific endocrine alterations, as for GHD which is associated with lower pituitary height and volume (PV).Purpose: Our aim was to identify the pituitary morphological alterations predicti...

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ea0081ep737 | Pituitary and Neuroendocrinology | ECE2022

Pituitary autoimmunity and hormonal changes in patients with severe obesity

Carbone Carla , Botta Graziella , Cirillo Paolo , Longo Miriam , Carotenuto Raffaela , Forestiere Daniela , Tolone Salvatore , Docimo Ludovico , Maiorino Maria Ida , Bellastella Giuseppe , Esposito Katherine

Background and aim: Obesity is associated with a dysregulation of the immune system which can result in a predisposition to the development of autoimmune diseases. The aim of this cross-sectional study was to evaluate anti-pituitary antibodies (APA) in severe obese patients, in order to identify a possible role of the immune system in obesity and to correlate these antibodies with pituitary hormone changes found in obese patients.Matherials and methods: ...

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ea0081ep738 | Pituitary and Neuroendocrinology | ECE2022

Visual impairment in the empty sella syndrome

Fatma Mnif , Zargni Asma , Arbi Kawthar El , Akid Faten Haj Kacem , Salah Dhoha Ben , Charfi Nadia , Mnif Mouna , Majdoub Nabila Rekik , Elleuch Mouna , Abid Mohamed

Introduction: Empty sella syndrome (ESS) is a rare condition in which the sella turcica is partially or completely filled with cerebrospinal fluid. It can be primary or secondary. Ophthalmologic involvement is rare in primary empty sella Syndrome. It is described in only 1.6 to 16% of cases. Patients and methods: We report a retrospective study of 46 cases of ESS collected in the endocrinology department over the period from 1991 to 2020. The clinical an...

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ea0081ep739 | Pituitary and Neuroendocrinology | ECE2022

Giant pituitary adenomas: about 15 cases

Zarraa Lamiae , Berrabeh Soumiya , Assarrar Imane , ROUF Siham , Latrech Hanane

Key Words: Giant pituitary adenomaIntroduction & Background: Giant pituitary adenomas are uncommon tumors defined by a tumor diameter ≥ 4 cm. Their prevalence estimated at 6-10% of all pituitary adenomas, whose clinical characteristics and prognosis are not well known. The purpose of this work was to evaluate the prevalence as well as the clinical and evolutionary characteristics of giant pituitary adenomas in our series.<p class="ab...

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ea0081ep740 | Pituitary and Neuroendocrinology | ECE2022

The changing features of a corticotroph PITNET: from silent to Cushing’s disease - case report

Andrei Emilescu Radu , Burcea Iulia Florentina , Dumitriu Roxana Ioana , Nicoleta Năstase Valeria , Ciubotaru Gheorghe Vasile , Gabriela Tătăranu Liga , Poiană Cătalina

Introduction: The spectrum of corticotroph cell pituitary adenomas is very wide, silent corticotroph adenomas (SCAs) being a rare subtype with positive immunohistochemistry for adrenocorticotropic hormone (ACTH), without causing Cushings disease. SCAs may exhibit a more aggressive behavior, and the changing of the clinical phenotype towards Cushings disease is described. Case report: We present the case of a 74 years old, ex-smoker, hypertens...

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ea0081ep741 | Pituitary and Neuroendocrinology | ECE2022

Growth hormone deficiency due to a rare central nervous system tumor

Gabriela Duta Simona , Pavel Sebastian , Stoica Sergiu , Fica Simona

Introduction: Short stature is a common reason for pediatric endocrine evaluation and it can have a variety of causes, including constitutional, genetic short stature, dysmorphic syndromes, chronic illnesses and also endocrine disorders. Growth hormone deficiency accounts for 8% of the cases and it can be isolated or associated with other pituitary hormones deficiencies, congenital or acquired, such as in central nervous system tumors.Case report: A 15-y...

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ea0081ep742 | Pituitary and Neuroendocrinology | ECE2022

Hypophysitis and reversible hypopituitarism developed after COVID-19 infection - a clinical case report.

Gorbova Natalia , Rozhinskaya Liudmila , Vladimirova Viktoria , Belaya Zhanna

Aim: To present a clinical case of reversible hypopituitarism due to hypophysitis developed after COVID-19 infection.Materials and methods: A patient with residual clinical manifestations of hypopituitarism underwent clinical evaluation at the time of symptoms of hypopituitarism and in follow-up. Morning serum cortisol (171-536 nmol/l) was measured by electrochemiluminescence immunoassay. Morning ACTH (7.2-63.3 pg/ml), prolactin (66-436 mU/l), TSH (0.25-...

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ea0081ep743 | Pituitary and Neuroendocrinology | ECE2022

Pituitary apoplexy and Staphylococcus infection in a previously undiagnosed macroadenoma

Alexandra Pirga Iulia

Background: Pituitary apoplexy is a rare clinical syndrome, caused by hemorrhagic or ischemic necrosis of the pituitary gland. It is often associated with an existing pituitary adenoma, especially nonfunctioning tumors. Pituitary apoplexy may mimic the clinical findings of an infectious meningoencephalitis. Case report: A 57-year-old man was admitted to the emergency department following sudden onset of severe headaches, fever, chills, and signs of menin...

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ea0081ep744 | Pituitary and Neuroendocrinology | ECE2022

Vanishing Pituitary tumour in a postpartum patient - a diagnostic dilemma

Meneissy Noha , Hosni Moustafa , Hossain Belayet , Low Barney , Bell Janessa , Halder Writaja , Falconer Debbie , Patel Shrini , Saleem Muhammad , Islam Saiful , Hussain Musarat , Howes Jessica , Rehmani Hassan , Mlawa Gideon , Qin Catherine

Introduction: Resolution of pituitary tumour without surgical intervention is rare. The mechanism of spontaneous resolution of pituitary adenoma is unclear but may be explained by either pituitary apoplexy or hypophysitis responding to steroids. Bray BP, et al(2021) reported the case of vanishing pituitary mass due pituitary apoplexy. Park SM, et al (2014) reported 22 cases of pituitary mass due hypophysititis which improved mostly with medical therapy.C...

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ea0081ep745 | Pituitary and Neuroendocrinology | ECE2022

Cardio-metabolic and articular complications of somatotropic adenomas in a single-center study

Faraoun Khadra , Fatiha Mohammedi

Introduction/Objective: Chronic exposure to hypersomatotropism exposes to multiple co-morbidities, rarely reversible, which can worsen both functional and vital prognosis and impair quality of life. The aim of our work is to list the different complications of acromegaly at the time of diagnosis.Patients and methods: Descriptive cross-sectional study concerning 81 patients with somatotropic adenomas followed in the Endocrinology department of the Oran Un...

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ea0081ep746 | Pituitary and Neuroendocrinology | ECE2022

Hormonal profile of pituitary adenomas

Faraoun Khadra , Fatiha Mohammedi

Background: Pituitary adenomas (PA) or endocrine pituitary tumors are the most common pituitary tumors. Our goal is to assess their hormonal profile.Patients and methods: Our study is observational, multicenter, with prospective and retrospective data collection. Data entry and analysis was performed by CDC (USA) EPI Info version 6, SPSS20, Statistica10, Medcalc12.Results: Concerning the hormonal profile of the 475 PA collected, 77...

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ea0081ep747 | Pituitary and Neuroendocrinology | ECE2022

Delayed Diagnosis of Cushing’s Disease Manifested in Adolescence

A. Vaychulis Irina

Diagnosis of Cushings syndrome (CS) can be challenging, particularly in mild cases or in cyclic disease, because of the variable, non-specific clinical manifestations and the overlap with more common medical problems. Female patient was referred to our clinic in Dec 2015, at the age of 18 years, presented with headaches, arterial hypertension (AH), excessive body hair growth, irregular menstrual periods, sleep disturbances and mood fluctuations. She smoked, but denied us...

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ea0081ep748 | Pituitary and Neuroendocrinology | ECE2022

Clinical, paraclinical and genetic features of diabetes insipidus

Mnif Fatma , Charfi Hana , Abdelhedi Fatma , Bouassida Malek , Elleuch Mouna , Salah Dhoha Ben , Mnif Mouna , Majdoub Nabila Rekik , Charfi Nadia , Akid Faten Haj Kacem , Kammoun Hassen , Abid Mohamed

Introduction: Diabetes insipidus (DI) is a rare pathology. The advent of hypothalamic-pituitary MRI has made it possible to make a positive diagnosis by avoiding the water restriction test (WRT). The etiological diagnosis is still a challenge in view of the diversity of diseases involved, which influences the therapeutic management and prognosis.Work Objectives: The objectives of our work were to describe the clinical, paraclinical and genetic features o...

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ea0081ep749 | Pituitary and Neuroendocrinology | ECE2022

Hypopituitarism revealing small cell pulmonary carcinoma: an original case report

Tekaya Asma , Kefi Asma , Abdelghani Khaoula Ben , Sassi Cyrine , Turki Sami , Euch Mounira El , Abderrahim Ezzedine

Background: Anterior pituitary insufficiency or anterior hypopituitarism is a defect in the secretion of one or more of the pituitary hormones (ACTH, TSH, FSH and LH, GHand prolactin). It is a rare condition. A variety of diseases may be the cause, the most common being adenoma. In rare cases, it can be a clinical presentation of metastatic disease. Herein, we describe a case of a pituitary metastasis revealing a lung carcinoma in a 61-year old man.Case ...

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ea0081ep750 | Pituitary and Neuroendocrinology | ECE2022

Neurosarcoidosis and pituitary metastasis of a small cell carcinoma: an unusual association

Mnif Fatma , Charfi Hana , Elleuch Mouna , Salah Dhoha Ben , Charfi Nadia , Mnif Mouna , Majdoub Nabila Rekik , Akid Faten Haj Kacem , Abid Mohamed

Introduction: Pituitary stalk thickening (PST) is often identified on magnetic resonance imaging (MRI), either incidentally or during diagnostic workup of hypopituitarism. Currently, there is no unified standard for the definition of PST. As a reference, a pituitary stalk with width over 3 mm has been used as the diagnostic criterion for PST in recent years. The disease spectrum of PST is quite diverse and can be grouped into three broad categories: neoplastic, inflammatory an...

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ea0081ep751 | Pituitary and Neuroendocrinology | ECE2022

Immunohistochemichal expression of ephrin receptor (EPH)-A4, -A5, -B2 and -B5 in pituitary lesions

Papadimitriou Eirini , Kyriakopoulos Georgios , Barkas Konstantinos , Gkalonakis Ioannis , Pantoula Panagiota , Theocharis Stamatios , Kaltsas Gregory , Alexandraki Krystallenia

Introduction: Ephrin receptors (EPHs) compose the largest known subfamily of receptors tyrosine kinases and are bound and interact with EPHs-interacting proteins (Ephrins). They have a role in tumor growth, invasion, angiogenesis and metastasis of several neoplasms. Aim of the study was to investigate the expression of EPH-A4, -A5, -B2 and -B5 in pituitary lesions. Material and Methods: Our study group consisted of 18 patients (9 males with median age 54...

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ea0081ep752 | Pituitary and Neuroendocrinology | ECE2022

Clinical presentation of non-functioning pituitary tumors: the experience at a tertiary care hospital in Portugal

Ines Alexandre Maria , Gomes Ana , Nobre Ema Lacerda , Marques Pedro , Bugalho Maria Joao

Introduction: Clinically non-functioning pituitary tumors (NFPTs) lack clinical or biochemical evidence of pituitary hormone excess. Their clinical presentation is heterogeneous, including mass effect-related symptoms and/or hypopituitarism, or even no symptoms in incidentally-detected NFPTs. We aimed to evaluate the clinical presentation spectrum of NFPTs in a cohort of patients managed at our hospital.Methods: Clinical, demographic, biochemical and ima...

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ea0081ep753 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly: a rare disease with multiple, complex complications

Istrate Andra Cristiana , Leustean Letitia , Ungureanu Maria- Christina , Teodoriu Laura , Bilha Stefana , Florescu Alexandru , Preda Cristina

Introduction: Acromegaly is a rare, challenging disease that if not appropriately treated can lead to numerous complications. Some of the most frequent complications are cardiovascular (hypertension, secondary cardiomyopathy, arrhythmias, valvulopathies, heart failure) and metabolic (secondary diabetes, various alterations of the lipid metabolisms). Aim: The aim is to asses the impact of long-term acromegaly on the cardiovascular system and glucide and l...

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ea0081ep754 | Pituitary and Neuroendocrinology | ECE2022

Early diagnostic tools in milder forms of central hypothyroidism in patients harbouring a pituitary adenoma: cross-sectional study on 142 patients from a single tertiary center

Galazzi Elena , Nicoli Federico , Carrara Silvia , Milan Chiara , Fatti Letizia Maria , Moro Mirella , Persani Luca

Introduction: Milder forms of central hypothyroidism (CeH) are still challenging to diagnose due to absence of gold standards, wide variability of fT4 values and aspecificity of symptoms. We aimed to find diagnostic clues at diagnosis (pituitary lesion dimensions, other hormonal deficit) and during long-term follow-up, guiding the clinician to a precocious diagnosis of CeH.Study: 142 patients harbouring a pituitary adenoma with complete pituitary assessm...

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ea0081ep755 | Pituitary and Neuroendocrinology | ECE2022

Pituitary adenomas and pregnancy: descriptive observational study

Veleno Miriam , Menotti Sara , Giampietro Antonella , Chiloiro Sabrina , Pontecorvi Alfredo , Marinis Laura De , Bianchi Antonio

Introduction: Pregnancy results in a significant change in pituitary gland size and function.Due to this physiological adaptation, management of pituitary adenomas during pregnancy represents a particularly complex challenge. Aim of this study was to focus on a single referral institution experience with special attention to this subgroup of patients: pregnant woman affected by pituitary adenoma.Materials and methods: This is a des...

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ea0081ep756 | Pituitary and Neuroendocrinology | ECE2022

Clinical & Epidemiological characteristics of patients undergoing pituitary-related surgeries in a tertiary care centre in Sri Lanka

Wijewickrama Piyumi , Ambawatte Sathyajith , Sumanatilleke Manilka , Garusinghe Chaminda , Garusinghe Sanjeewa , Attanayake Deepal , Kularatne H.K. de. S , Saman Wadanambi , Somasundaram Noel P

Introduction: For clinically relevant sellar masses, early identification and effective endocrine & surgical management is the key. National Hospital of Sri Lanka (NHSL), which is the largest tertiary care centre in Sri Lanka, manages a wide variety of patients with sellar/supra-sellar pathologies, regularly conducting pituitary related surgeries. The aim of the current study was to determine epidemiological and clinical characteristics as well as immediate post-operative ...

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ea0081ep757 | Pituitary and Neuroendocrinology | ECE2022

Fluid and sodium disorders in patients undergoing pituitary related surgeries in a tertiary care centre in Sri Lanka, with associations and risk factors; a prospective, observational study

Wijewickrama Piyumi , Ambawatte Sathyajith , Sumanatilleke Manilka , Garusinghe Chaminda , Kamaladasa Kasun , Somasundaram Noel P

Introduction: Fluid and sodium disorders are a relatively frequent occurrence after sellar/supra-sellar surgeries. National Hospital of Sri Lanka (NHSL) is the main tertiary care centre in Sri Lanka, conducting regular pituitary surgeries. Methods: A prospective cross-sectional study was conducted in all adults (above 15-years) undergoing pituitary-related surgeries in NHSL over 18 months from September 2019. The relationship between demographic factors,...

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ea0081ep758 | Pituitary and Neuroendocrinology | ECE2022

Severe growth retardation due to pituitary stalk agenesis: a case report

Rifai Kaoutar , Azriouil Manale , Kamel Farah , Elmoatamid Kaoutar , Guissi Loubna , Iraqi Hinde , Gharbi Mohamed Elhassan

Introduction: Growth retardation is considered severe when the height of the child is -3 standard deviation (SD) below the average height in reference to the growth curves of children of the same sex and age. Pituitary stalk interruption syndrome (PSIS) is one of the most common conditions in children with short stature.Case report: We report the case of a 12-years old boy with no clinical history of perinatal injury or traumatic birth, who was admitted ...

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ea0081ep759 | Pituitary and Neuroendocrinology | ECE2022

About two cases of adipsic hypernatremia in adults, one with proven blood antibodies against subfornical organ (SFOAb).

Charfi Lilia , Dupuis Hippolyte , Lucile Szuwarski , Christine Gillot , Akari Utsunomiya , Vantyghem Marie-Christine

Adipsic hypernatremia, a rare hypothalamic disorder characterized by a loss of thirst in response to hypernatremia is more often reported in children. An autoimmune mechanism has been recently demonstrated. We report two cases.Case1: A lean 67-year-old female, with a history of multilocular sclerosis, was admitted, for severe hypernatremia (162 mmol/l) with low ADH level (0.5 pmol/l; N: 0.5-2). She did not complain of thirst, despite ideomotor slowing an...

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ea0081ep760 | Pituitary and Neuroendocrinology | ECE2022

Features of the incidence of postoperative complications in patients with transsphenoidal pituitary adenectomy

Inomova Gulmira , Halimova Zamira , Kuldasheva Yayrahon

Target.: To study the incidence of postoperative complications in patients with transsphenoidal pituitary adenoectomy.Materials and research methods: 180 cases of PA subjected to T&Rcy;&Acy; for the period from 2018 to 2020 were analyzed. Of these, 102 (56.6) women, 78 (43.3) men, patients were divided into two alternative groups: the first group - 93 (51.6%) patients with macroadenomas - 42 (45.2%) men, women 51 (54.8%), the second (comparison group) - ...

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ea0081ep761 | Pituitary and Neuroendocrinology | ECE2022

Skeletal complications in Cushing’s disease (CD)

Miljic Dragana , Djurdjevic Sandra Pekic , Doknic Mirjana , Stojanovic Marko , Djurovic Marina Nikolic , Jemuovic Zvezdana , Radić Nevena , Radovic Sara , Petakov Milan

Introduction: Structural and functional damage of the skeletal system resulting in fractures is a common complication of CD. Due to major effect of glucocorticoids on the trabecular bone, vertebral fractures are a common and severe complication which can lead to disability.Goal: To investigate the prevalence of skeletal complications (osteoporosis, osteopenia, presence of fragility fractures) in patients with Cushings disease, as well as gain insig...

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ea0081ep762 | Pituitary and Neuroendocrinology | ECE2022

Feasibility and effectiveness of switching patients with acromegaly receiving long-acting octreotide to lanreotide (Somatulin Autogel)

Zanozina Olga

Medical therapy of patients with acromegaly is an important addition to surgical treatment or an alternative to it when it is impossible to use the latter. Long-acting synthetic analogues of somatostatin (octreotide and lanreotide) act on the same subtypes of somatostatin receptors, but the drugs have been shown to differ in efficacy and tolerability.Objective: to achieve complete clinical and laboratory remission in patients with acromegaly, which did n...

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ea0081ep763 | Pituitary and Neuroendocrinology | ECE2022

Abstract Withdrawn...

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ea0081ep764 | Pituitary and Neuroendocrinology | ECE2022

Clinical characteristics, treatment and outcomes of well-differentiated gastroenteropancreatic G3 NET

Opalinska Marta , Staszczak Anna Sowa , Kurzyńska Anna , Morawiec-Sławek Karolina , Stefańska Agnieszka , Hubalewska-Dydejczyk Alicja

Background: Although gastroenteropancreatic neuroendocrine tumors G3 (GEP-NET G3) and neuroendocrine cancers (GEP-NEC G3) are characterized in histopathological examination by Ki67>20% or >20 mitoses/10HPF their management and prognosis is substantially different. Despite the WHO introduces the novel well-differentiated neuroendocrine tumour of high grade (NET G3) classification in 2017 the clinical management of them is still challenging due to high NET G3 heterogenei...

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ea0081ep765 | Pituitary and Neuroendocrinology | ECE2022

Head and neck paragangliomas: the belfast trust experience

Darrat Milad , Bailie Neil , Hampton Susie , Cooke Stephen , Weir Philip , Lau Louis , Herron Brian , Morrison Patrick J , Johnston Philip

Background: Head and neck paragangliomas (HNPGL) are rare, usually benign slow-growing tumours arising from neural crest-derived tissue. Definitive treatment strategies for HNPGL have not been clearly defined.Aims: To provide a comprehensive review of our institutional experience of the clinical features, investigations, management and follow up of this cohort.Methods: Baseline clinical information was taken from a prospectively ma...

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ea0081ep766 | Pituitary and Neuroendocrinology | ECE2022

A paradox in clinical practice: the case of a hidden tubercoloma

Parolin Matteo , Parisotto Matteo , uliana ambra , Sartorato Paola , Menis Ernesto De

Introduction: A potential cause of panhypopituitarism could be cerebral tubercular lesions, that are often misdiagnosed. Hormonal effects could be related directly to primary tubercular lesions, or after starting antitubercular therapy. Paradoxical reaction (PR) in tuberculosis is defined as clinical or radiological worsening of pre-existing tuberculous lesions or development of new lesions after beginning an appropriate antitubercular therapy (ATT). It has been suggested that...

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ea0081ep767 | Pituitary and Neuroendocrinology | ECE2022

‘The efficiency of the treatment by Sandostatin-Lar in patients with non-functional pituitary macroadenomas’

Mirtukhtaeva Malika , Grossman Ashley , Leekha Nitin , Akbutaev Alisher , Yulduz Urmanova

The purpose of the study: Is to study the efficiency of the treatment by Sandostatin-Lar in patients with non-functional pituitary macroadenomas (NFPA) Material and methods.: Under our observation there were 20 patients with NFPA, of whom women were 8, men - 12. The average age of patients was 29,2/36.4 years. All patients were subjected to transnasal adenomectomy of pituitary gland (TAG) in our clinic. The whole patients were performed by research compl...

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ea0081ep768 | Pituitary and Neuroendocrinology | ECE2022

Clinical, paraclinical, therapeutic and evolution profile of pituitary adenomas: about 92 cases

Abdellaoui Wahiba , Assarrar Imane , Zarraa Lamiae , Berrabeh Soumiya , Rouf Siham , Latrech Hanane

Introduction: Pituitary adenomas represent about 10 to 20% of all intracranial tumors. They are usually classified according to their size into pico-adenomas, micro-adenomas and macro-adenomas, but can also be classified according to their secretory properties into secreting or nonfunctional adenomas. In this study, we describe the clinica, paraclinica, therapeutic and evolution features of pituitary adenomas in our center.Material and methods: A retrosp...

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ea0081ep769 | Pituitary and Neuroendocrinology | ECE2022

A challenging case of sheehan syndrome

Rita Elvas Ana , Vieira Ine s , Melo Miguel , Rodrigues Di rcea , Gomes Maria Leonor , Paiva Isabel

Introduction: Sheehan Syndrome (SS) is a cause of hypopituitarism resulting from postpartum pituitary infarction. Its frequency is decreasing worldwide, particularly in developed countries due to advances in obstetric care. Case report: A 50-year-old female patient was admitted to the emergency department with complains of progressive pain in the lower hemithorax and abdomen. She also referred constipation, weight gain and asthenia. The initial laborator...

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ea0081ep770 | Pituitary and Neuroendocrinology | ECE2022

A case with primary autoimmune hypothyroidism causing pituitary enlargement mimicking pituitary macroadenoma and secondary adrenal insufficiency

Burak Yaşar Mustafa , Alak Zehra Yagmur Sahin , Guller Pinar Uzgec , Guclu Metin , Aydemir Fatih , Kiyici Sinem

Introduction: In primary hypothyroidism, the increase in TRH may cause hyperplasia in the pituitary gland. It has been reported that long-standing hypothyroidism might also cause irreversible pituitary damage, which may lead to a deficiency in one or more pituitary hormones. Herein, we report a case with primary autoimmune hypothyroidism causing pituitary enlargement mimicking pituitary macroadenoma and secondary adrenal insufficiency. Case: A 17-year-ol...

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ea0081ep771 | Pituitary and Neuroendocrinology | ECE2022

The management of hypophysitis in Covid-19

Menotti Sara , Veleno Miriam , Giampietro Antonella , Chiloiro Sabrina , Mattogno Pier Paolo , Giorgio D'Alessandris Quintino , Lauretti Liverana , Gaudino Simona , Doglietto Francesco , Pontecorvi Alfredo , Marinis Laura De , Bianchi Antonio

Introduction: Literature has already described some cases of hypophysitis related to acute respiratory syndrome coronavirus 2 (SARS-Cov2). The pituitary is indeed target for the virus due to the angiotensin-converting-enzyme-2 expression. Hypophysitis patients present with mass effect and pituitary dysfunction related symptoms. ACTH and TSH deficiencies are the most reported, along with central diabetes insipidus (CDI). The best way to manage these hypophysitis is still undefi...

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ea0081ep772 | Pituitary and Neuroendocrinology | ECE2022

Case of a giant prolactinoma presenting as a clival mass

Uzgec Guller Pinar , Burak Yaşar Mustafa , Alak Zehra Yagmur Sahin , Guclu Metin , Aydemir Fatih , Kiyici Sinem

Introduction: Giant prolactinomas are rare tumors accounting for 216% of all prolactinomas. They may be aggressive and invasive. Rarely, they might not have a suprasellar component and grow downward. Such extension can make it difficult to distinguish pituitary adenoma from other skull base tumors. We present a case that was considered to be chordoma based on clinical and radiological imaging features, but was diagnosed as prolactinoma by pituitary biopsy.<p class="a...

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ea0081ep773 | Pituitary and Neuroendocrinology | ECE2022

Clinical and paraclinical features of pituitary metastases: Report of five cases

Chehaider Cyrine , Oueslati Ibtissem , Yazidi Meriem , Chihaoui Melika

Introduction: The sellar region is known as a low-risk brain metastasis area. The prevalence of pituitary metastasis represents 1% of all surgical tumors of the pituitary gland. In most cases, pituitary metastasis is identified in patients with a prior history of cancer. In a few cases, it can reveal the primary tumor. The aim of this study was to assess clinical and paraclinical features of pituitary metastasis. Methods: This was a retrospective and des...

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ea0081ep774 | Pituitary and Neuroendocrinology | ECE2022

Cushing’s syndrome due to adrenocorticotropic hormone-secreting metastatic neuroendocrine pancreatic tumor: diagnostic workup and management

Cosentino Giada , Manetti Luca , Marconcini Giulia , Boggi Ugo , Marconcini Riccardo , Lupi Isabella , Cappellani Daniele , Urbani Claudio , Bogazzi Fausto

We report the clinical history of a 21-years old young female who, in February 2021, presented abdominal pain and biliary vomiting that lasted for two months. An esophagus-gastroduodenoscopy revealed a duodenal ulcerative lesion and proton pump inhibitory therapy was started with clinical benefit. One month later, the patient presented a facial acneiform rush with hirsutism for which she was referred to our attention. An abdominal MRI documented a well-circumscribed hyper-vasc...

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ea0081ep775 | Pituitary and Neuroendocrinology | ECE2022

Distribution of E- and N-cadherin in subgroups of non-functioning pituitary neuroendocrine tumours

Astrid Berland Oystese Kristin , Casar-Borota Olivera , Berg-Johnsen Jon , Berg Jens Petter , Bollerslev Jens

Purpose: Clinically Non-Functioning Pituitary Neuroendocrine Tumours (NF-PitNETs) present a varying degree of aggressiveness, and reliable prognostic markers are lacking. We aimed to characterize the distribution of E- and N-cadherin in corticotroph, PIT1 and null-cell NF-PitNETs, and link it to the clinical course of the tumours.Methods: We investigated the distribution of E- and N-cadherin by immunohistochemistry in a retrospective cohort of thirty tum...

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ea0081ep776 | Pituitary and Neuroendocrinology | ECE2022

Primary cilia in Pituitary neuroendocrine tumours and their association with aggressiveness

Martinez-Hernandez Rebeca , Serrano-Somavilla Ana , Sampedro-Nunez Miguel , Calatayud Mari a , Vicente Almudena , Garcia-de-Casasola Gonzalo , Sanz-Garcia Ancor , Puig-Domingo Manel , Marazuela Monica

Purpose: Although growing evidence supports the role of primary cilia (PC) in the regulation of cancer development, their possible role has not yet been studied in pituitary neuroendocrine tumours (PitNETs). The study of cilia could serve as a diagnostic tool providing new insights into the mechanisms of tumorigenesis and aggressiveness of PitNETs. Methods: A total of 86 patients with PitNETs (28 functioning and 58 non-functioning [NF-PitNETs]) and 12 co...

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ea0081ep777 | Pituitary and Neuroendocrinology | ECE2022

Cushing’s disease in MEN 4 syndrome

Rebrova Dina , Zgoda Ekaterina , Krasnov Leonid , Rusakov Vladimir , Sleptsov Ilya , Chernikov Roman , Semenov Arseny , Fedorov Elisey , Chinchuk Igor , Sablin Ilya , Shihmagomedov Shamil , Shcherbakov Ilya

In 2000 female, 28 y.o., admitted endocrinologist with headache, high blood pressure, dark skin and muscle weakness. Lab data showed high levels of ACTH and cortisol, low potassium level. According to MRI scans, pituitary gland seemed normal. On CT in right adrenal was found 32 mm mass with the native density of 20 HU. Diagnosed ACTH-dependent Cushing syndrome (CS). As Mitotane was not available in Russia at that time, she received ketokonazole due to progression of CS but it ...

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ea0081ep778 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly with negative pituitary magnetic resonance imaging: a case report

Grassa Anis , Oueslati Ibtissem , Yazidi Meriem , Kamoun Elyes , Chihaoui Melika

Introduction: Acromegaly is a rare endocrine disorder. In 95% of cases, it is caused by a GH-secreting pituitary adenoma. Rarely, acromegaly is due to ectopic production of GH or growth hormone-releasing hormone (GHRH). Herein, we report a case of acromegaly with negative pituitary magnetic resonance imaging (MRI) and discuss its possible etiology and management.Observation: A 75-year-old woman was referred to our department for the exploration of acquir...

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ea0081ep779 | Pituitary and Neuroendocrinology | ECE2022

TSH-secreting pituitary neuroendocrine tumor revealed after total thyroidectomy, a case study

Khadidja Bessaid , Mezoued Mouna

Introduction: TSH-secreting pituitary neuroendocrine tumor (TSH-PitNET) is the rarest pituitary tumors. Most TSH-PitNETs are secreting, with a biological profile of inappropriate TSH secretion (moderately elevated TSH, elevated FT3 and FT4).Observation: We report the case of a 69-year-old patient, with a history of total thyroidectomy in 2014 for multinodular goiter, hospitalized for suspected levothyroxine pseudo-malabsorption. Despite doses above 2 &#1...

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ea0081ep780 | Pituitary and Neuroendocrinology | ECE2022

Null cell adenoma with low Ki-67 presenting as recurrent pituitary mass

Tiu Leo , Montano Carolyn

Background: Approximately one-third of pituitary adenomas are identified as nonfunctioning pituitary adenomas (NFPA) which have a heterogenous profile and an increased potential for relapse one to five years after pituitary surgery. In a retrospective analysis by Almeida et al, multiple surgical resections, elevated ki-67 and cavernous sinus invasion were predictive of recurrence. They typically present with symptoms of mass effect and most are macroadenomas at time of diagnos...

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ea0081ep781 | Pituitary and Neuroendocrinology | ECE2022

Discordant GH and IGF-1 values in a surgically treated acromegaly patient: a management conundrum

Mustata Theodor , Martin Carmen Sorina , Parfeni Ovidiu , Dumea Bianca , Predescu Florina Andrada , Simona Fica

Introduction: Remission after transsphenoidal surgery in patients with acromegaly is confirmed by biochemical assays of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Although their levels are usually closely correlated, discordant results of these tests have been noted, making the follow-up of acromegaly patients particularly challenging.Case report: We present the case of a 35 year old female diagnosed with acromegaly at the age of 32 ye...

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ea0081ep782 | Pituitary and Neuroendocrinology | ECE2022

Screening of IGF-1 level in patients with Prolactinomas

Ukhanova Yulia , Ilovayskaya Irena

Objective: to determine the need for screening for IGF-1 levels in patients with prolactinomas and without obvious symptoms of acromegaly. Matherials and methods: A pilot cross-sectional study, based on the analysis of medical records of patients with confirmed prolactinoma, who applied to the Moscow Regional Research and Clinical Institute named by M.F. Vladimirsky. A total of 88 patients were included in the study. The frequency of studying the level o...

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ea0081ep783 | Pituitary and Neuroendocrinology | ECE2022

Polyuria-polydipsia in an athletic teenager

Rosu Mihaela , Baleanu Felicia , Georgiana Taujan , Kosmopoulou Olga , Papadopoulou Blerta , Gambini Luiza , Laura Iconaru

Introduction: Central diabetes insipidus is characterized by partial or total ADH deficit of various origins. The clinical picture is dominated by massive polyuria with diluted urine, increased thirst and daily water consumption reaching impressive quantities. Case report: We report the case of a 16 year-old male teenager presenting with excessive thirst and water intake of 8 -10 l/day and voiding large quantities of diluted urine. Symptoms started gradu...

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ea0081ep784 | Pituitary and Neuroendocrinology | ECE2022

A novel population of activated cytotoxic T cells infiltrate pituitary neuroendocrine tumour subytpes

Mazzitelli Oriana , Ebejer Jean Paul , Pace Nikolai Paul , Gruppetta Mark , Vassallo Josanne , Saliba David

Non-functional pituitary adenomas (NFPA) are non-hormone secreting pituitary tumours while growth hormone-secreting pituitary adenomas (GHPA) are active pituitary tumours causing acromegaly. Since immunotherapy is becoming the preferred therapeutic strategy in cancers, understanding the diversity of immune cells infiltrating the tumour microenvironment is warranted. However, little is known about the immune landscape of pituitary tumours. We validated an acoustic-assisted hydr...

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ea0081ep785 | Pituitary and Neuroendocrinology | ECE2022

Clinical case of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) with uncertain localization

Pigarova Ekaterina , Dzeranova Larisa , Katamadze Nino , Fargieva Khava , Malysheva Natalya , Nikankina Larisa , Przhiyalkovskaya Elena

Introduction: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is characterized by hypotonic and euvolemic hyponatremia along with urinary hyperosmolarity, resulting from antidiuretic hormone (ADH) release in the absence of adequate stimuli.Case report: A 59-year-old woman, presented with complaints of constant thirst, general weakness, memory loss, episodes accompanied by headaches, leg cramps, increased blood pressure. From the a...

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ea0081ep786 | Pituitary and Neuroendocrinology | ECE2022

Epidemiological data of prolactinomas in the Republic of Uzbekistan

Khalimova Zamira , Safarova Mijgona

Objective: To create a national register of prolactin-secreting pituitary adenomas to assess the prevalence of various forms and the effectiveness of therapy.Material and research methods: National register of patients with pituitary prolactinomas in the Republic of Uzbekistan, includes 172 cases with pituitary prolactinomas, of which 61% (105 women) and 37.2% (64 men), aged 17-74 years, mean age 38.5 &pm; 12.6 years and 3 (1.7%) children and adolescents...

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ea0081ep787 | Pituitary and Neuroendocrinology | ECE2022

The Nelson’s Syndrom (about 3 cases)

Steve Kamgain Simeu Lionel , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: The Nelsons syndrom (NS) is defined by the development of an ACTH pituitary adenoma. Complication of bilateral adrenalectomy performed in some cases of Cushings disease.We report the observation of three patients.Case1: 34-year-old patient, followed for Cushings disease with pituitary microadenoma, having undergone pituitary surgery, then bilateral adrenalectomy due to surgical failure. Presented two...

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ea0081ep788 | Pituitary and Neuroendocrinology | ECE2022

Case report in a patient with insulinoma

Cheshlaroska Markushoska Katerina , Todorova Biljana , Cheshlaroska Hristina , Jovanoska Belma Bilaloglu

Introduction: An insulinoma is a neuroendocrine tumor, deriving mainly from pancreatic islet cells, that constantly produces insulin even when blood sugar is very low. Insulinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. Biochemical diagnosis of insulinoma is established during prolonged fasting test (up to 72 hours) in 95 % of patients, 90-95% of insulinomas can be diagnosed during 48 hours of prolonged fasting. After biochemical co...

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ea0081ep789 | Pituitary and Neuroendocrinology | ECE2022

GH provocative tests stimulate the growth in children without GH deficiency

Tortora Anna , Marotta Vincenzo , Izzo Giulia , Rocco Domenico , Clemente Gennaro , Vitale Mario

Introduction: GH deficiency (GHD) is a clinical disorder characterized by pathological short stature in the child, altered body composition, impaired psychological well-being and reduced quality of life. These alterations are almost always reversible after recombinant human GH (rhGH) administration, which is currently the only accepted treatment for the subjects with GHD. Secretory dysfunction is confirmed when GH peak does not reach the established cut-off in at least two dif...

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ea0081ep790 | Pituitary and Neuroendocrinology | ECE2022

Sarcopenia and frailty in acromegalic patients

Ugur Kader , Eryeşil Hasan , Fazıl Akkoc Ramazan , Karatas Ahmet

Introduction: Acromegaly is a clinical syndrome associated with excess growth hormone. The present study aimed to investigate sarcopenia and frailty, which could affect mortality and morbidity, in patients with acromegaly.Method: Twenty outpatients diagnosed with acromegaly were included in the study. The hand muscle strength of the patients was measured by electronic hand dynamometer (Model EH101, Zhongshan Camry Electronic Co. Ltd. China). Computed tom...

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ea0081ep791 | Pituitary and Neuroendocrinology | ECE2022

A mini case series of hypophysitis with atypical presentation

Dilara Tekin Uzman Rukiye , Aksoy Ş eyma , Burhan Sebnem , Niyazoğlu Mutlu , Şuheda Hatipoğlu Esra

Introduction: Hypophysitis is a rare condition characterized by inflamation of the pituitary gland, causing mass effect and hypopituitarism. The incidence is estimated to be 1in9 million/year. The diagnosis of hypophysitis is based on clinical and laboratory findings, imaging methods and histopathology in selected cases. The aim of the treatment is to eliminate the compression effects of the mass and to treat hypopituitarsim. The first choice in medical treatment is immunsupre...

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ea0081ep792 | Pituitary and Neuroendocrinology | ECE2022

The natural course of hypopituitarism at diagnosis and following therapy in non-functioning pituitary macroadenomas

Hussein Ziad , Marcus Hani J , Grieve Joan , Dorward Neil , Bouloux Peirre , Baldeweg Stephanie

Background: Non-functioning pituitary macroadenomas (NFPMs) may present with hypopituitarism. Pituitary surgery and radiotherapy pose an additional risk to pituitary function.Aims: The aim of this study was to assess the incidence of hypopituitarism pre-operatively and the impact of surgery and radiotherapy on pituitary function. Methods: All patients treated with surgery and radiotherapy for NFPMs between 1987 and 2018 with more t...

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ea0081ep793 | Pituitary and Neuroendocrinology | ECE2022

Importance of neurosurgical expertise and multidisciplinary approach in pituitary patients

Pederzoli Simone , Monzani Maria Laura , Vincentis Sara De , Madeo Bruno , Diazzi Chiara , Rochira Vincenzo

Background: Multidisciplinary approach to pituitary disease is highly recommended; it requires a close relationship between expert pituitary surgeons and endocrinologists together with several specialists (e.g. neuroradiologists) in order to provide a high-level standard of care. Although there is evidence that neurosurgeons expertise is a key element to achieve better outcomes, also endocrinologists role is fundamental but it may sometimes encounter real-life barr...

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ea0081ep794 | Pituitary and Neuroendocrinology | ECE2022

Pituitary deficiencies after brain injury: a practical approach to evaluation and management

Wexler Tamara

While increasing attention is being paid to the health effects of brain injury, the role that neuroendocrine dysfunction may play in patients health after traumatic brain injury (TBI) remains underappreciated. Pituitary deficiencies are seen at a high rate in patients who have sustained TBI, with reports of chronic pituitary dysfunction in 15-60% of adults after TBI, and up to 42% of children and adolescents. Deficiencies may resolve over time, or develop years after inj...

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ea0081ep795 | Pituitary and Neuroendocrinology | ECE2022

Response to classic dynamic tests of a corticotropinoma due to Nelson’s syndrome

Adamidou Foteini , Komzia Paraskevi , Divaris Efstathios , Panagiotou Athanasios , Kita Marina

Introduction: Nelsons syndrome is a rare complication of Cushings disease treated with bilateral adrenalectomy. There is no effective medical treatment yet. Nelsons patients respond to hypothalamic stimuli distinctly from patients with Cushings disease and those with Addisons disease. We describe the responses to standard ACTH stimulation tests in a patient with Nelsons syndrome.Case report: A 42-year-old woman present...

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ea0081ep796 | Pituitary and Neuroendocrinology | ECE2022

Incidental discovery of pituitary insufficiency after non-pituitary surgery

Khutsishvili Tamari , Lomtadze Irine , Baratashvili Miranda

Introduction: Pituitary Insufficiency is life threatening condition, that can lead or manifest by any stressful situation (surgery, infections, intoxication and etc) Case report: A 70-year-old man diagnosed with Bladder Cancer had underwent surgery - Cystoplasty. The operation was performed without complications, but, after the intervention, the general condition of the patient sharply declined. There appeared strong general weakness, blurred consciousne...

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ea0081ep797 | Pituitary and Neuroendocrinology | ECE2022

Severe heart failure in a young male with unrecognized hypopituitarism

Caric Bojana , Stojanovic Marko , Malesevic Gabrijela , Nikolić Siniša , Grbic Aleksandra , Miljić Dragana

Background: The partial or complete hypopituitarism is described as late complication of hemorrhagic fever with renal syndrome (HFRS). Imaging methods of pituitary gland examination in the chronic phase showed pituitary atrophy, but a precise pathogenic mechanism that causes pituitary damage in HRFS remains unclear. While hypopituitarism in HFRS is rarely described, cardiac failure as a known complication of hypopituitarism is even more rarely described. We present a case of s...

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ea0081ep798 | Pituitary and Neuroendocrinology | ECE2022

Silent somatropic adenoma in young girl about a case

Ludwine Bifoume Ndong Charlene , Zahra El Jaafari Fatima , Rafi Sana , Mghari Ghizlane EL , Ansari Nawal EL

Introduction: Clinically non-secreting pituitary adenomas are rare in children We report a case of a silent somatotropic adenoma revealed by anatomopathology.Case: A 13 year-old patient with no prior history of sudden onset intracranial hypertension syndrome. Clinical examination showed no dysmorphic Syndrome, no galactorrhea, no delay or statutory advance, Tanner P1S3. The MRI reveals a heterogeneous tumor process intra and suprasellar of 30 mm *15 mm o...

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ea0081ep799 | Pituitary and Neuroendocrinology | ECE2022

Endocrine dysfunction in hemochromatosis

Salem Maram Ben , Grira Wafa , Khessairi Nadia , Yazidi Meriem , Chihaoui Melika

Introduction: Hemochromatosis is associated with iron overload that is responsible of iron deposit causing multiple organ dysfunctions which affects especially endocrine glands.Methods: We report four cases of pituitary hemochromatosis responsible of endocrine dysfunction. Results: Three women and one man were included, aged respectively 28, 19, 26 and 35 years old. These patients were suffering from ß-thalassemia and treated ...

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ea0081ep800 | Pituitary and Neuroendocrinology | ECE2022

Hyperprolactinemia, thyrotropic and corticotropic insufficiency in a patient with end-stage renal failure

Mouelhi Yasmine , Khessairi Nadia , Terzi Ameni , Yazidi Meriem , Chihaoui Melika

Introduction: Hyperprolactinemia is a condition of elevated prolactin levels in blood which could be physiological, pathological, or idiopathic in origin. Some cases of hyperprolactinemia have been reported in patients with renal failure. We present a case of hyperprolactinemia, thyrotropic and corticotropic insufficiency in a patient with end-stage renal failure.Case presentation: The patient was 27 years old, with a history of hypertension, renal insuf...

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ea0081ep801 | Pituitary and Neuroendocrinology | ECE2022

PE in Surgically Treated Cushing’s Disease: A Case Report

Gvazava Ketevan , Zavrashvili Nino , Chanturishvili Ketevan Shonia Natia , Margvelashvili Natia , Gvazava Qetevan , Zavrashvili Nino , Margvelashvili Natia , Shonia Natia , Chanturishvili Ketevan

Title: Pulmonary Embolism in Surgically Treated Cushings Disease: A Case ReportAuthors: Qetevan Gvazava1, Nino Zavrashvili1, Natia Margvelashvili2, Natia Shonia2, Ketevan Chanturishvili2 Endocrinology Department, Tbilisi Institute of MedicineBackground: Cushings disease is the most common cause of Cushings syndrome but can be very difficult to diagnose and to treat. as we know it has numerous health effects on pat...

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ea0081ep802 | Pituitary and Neuroendocrinology | ECE2022

Hypothalamic neuropeptides as biomarkers for water-electrolyte disturbances

Katamadze Nino , Shutova Aleksandra , Pigarova Ekaterina , Dzeranova Larisa , Fargieva Khava

Hypothalamic neuropeptides as biomarkers for water-electrolyte disturbances. Introduction Diabetes insipidus is a rare condition characterized by excretion of large amounts of dilute urine and increased thirst. Nephrogenic diabetes insipidus (NDI) is caused by the inability of the kidneys to concentrate urine in response to vasopressin.Aim: The aim of our case report is to present the patient with NDI and to report the data on physiological changes in hy...

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ea0081ep803 | Pituitary and Neuroendocrinology | ECE2022

Hashimoto’s encephalopathy : a case report

Mhamdi Zineb , Rifai Kaoutar , Iraqi Hinde , Gharbi Mohamed Hassan

Introduction: Hashimotos encephalopathy or SREAT (steroid-responsive encephalopathy associated with auto-immune thyroiditis) is a rare autoimmune disorder that is particularly corticosensitive and whose pathogenesis remains poorly understood. It is associated with high levels of antithyroid antibodies in plasma and/or CSF. Clinical manifestations are deceptive and may include cognitive and behavioral disturbances, seizures or abnormal movements.Cas...

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ea0081ep804 | Pituitary and Neuroendocrinology | ECE2022

Gestational diabetes insipidus: about a case

Elkhomri Amal , Salma Bensbaa , Haraj Nassim Essabah , Siham El aziz , Chadli Asma

Introduction: Diabetes insipidus during pregnancy is rare (4/100,000 pregnancies) generally occurring in the last two trimesters. It can be a previous diabetes insipidus, revealed by pregnancy, or a gestational diabetes insipidus. It would be secondary to the plasma degradation of antidiuretic hormone by placental vasopressinase.Observation: We report the case of a 34-year-old patient, with no history of head trauma, radiation, infiltrative or autoimmune...

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ea0081ep805 | Pituitary and Neuroendocrinology | ECE2022

Endocrinopathy behind the facemask

Nyunt Sandhi , Avari Parizad , Tarigopula Giridhar , Martin Niamh , Mitchell Catherine , Ling Yong Yong

A 44-year-old gentleman presented to the Emergency Department with a 2-week history of fevers and rigors. Past medical history was unremarkable other than an earlier diagnosis of hypertension. He was noted to have new onset atrial fibrillation with rapid ventricular response, and a new diagnosis of hypertrophic obstructive cardiomyopathy (HOCM) was made on echocardiography. In addition, a vegetation was identified on the mitral valve. Treatment for infective endocarditis (Stre...

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ea0081ep806 | Pituitary and Neuroendocrinology | ECE2022

Pituitary hypertrophy secondary to primary hypothyroidism (one case report)

Steve Kamgain Simeu Lionel , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: There are several causes of sellar and suprasellar mass, and pituitary hyperplasia secondary to primary hypothyroidism has been reported in the literature.Case report: 20-year-old patient, born from a consanguineous marriage, presenting with failure to thrive. Patient reporting no tumor syndrom. Clinical examination: Height at 88 cm (<-4 SD), weight at 18 kg (<3rd percentile), BMI at 23 kg/m2. TANNER at G2P0, micropenis length of 5 ...

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ea0081ep807 | Pituitary and Neuroendocrinology | ECE2022

Giant prolactinoma in an adolescent girl revealed by visual impairment

Asbar Hind , Ouakrim Hind , Rafi Sana , Mghari Ghizlane El , Ansari Nawal El

Introduction: Pituitary adenomas are rare in infants and adolescents. Prolactinomas account for 50% of these pituitary adenomas. In adolescent girls, it is usually a microprolactinoma revealed by puberty delay or amenorrhea. We report a rare case of a macroprolactinoma in an adolescent girl revealed by visual impairment.Case presentation: A 15-year-old adolescent girl presented with loss of vision over a long period of time. Magnetic resonance imaging re...

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ea0081ep808 | Pituitary and Neuroendocrinology | ECE2022

Inappropriate antidiuretic hormone secretion syndrome associated with covid 19 pneumonia

Mezzi Amani , Bchir Najla , Chedia Zouaoui , yosra abderrahim , anaam chhida , Haroun Ouertani

Introduction: Hyponatremia is a commonly associated with atypical pneumonia. One of its pathophysiological mechanisms is inappropriate antidiuretic hormone secretion(SIADH). We describe the case of a patient presenting an SIADH caused by COVID19 infection.Observation: We report a case of a 70-year-old man, known to have well-controlled hypertension, with a medical history of cavums neoplasia treated with radiotherapy and hypothyroidism post thyroid...

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ea0081ep809 | Pituitary and Neuroendocrinology | ECE2022

Association between uncontrolled acromegaly and nasopharyngeal tumor-case presentation

Nicoleta Nastase Valeria , Iulia-Florentina Burcea , Ceausu Amalia Raluca , Cimpean Anca Maria , Raica Marius , Poiana Catalina

Introduction: Acromegaly is characterized by elevated levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), most often due to a pituitary tumor. Persistent high levels of these hormones lead to a constellation of signs and symptoms and systemic complications associated with increased mortality. A potential association between acromegaly and cancer has been hypothesized regarding colorectal, thyroid, and prostate cancers, but there are few or no descriptions f...

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ea0081ep810 | Pituitary and Neuroendocrinology | ECE2022

Hypopituitarism in adults - the importance of clinical suspicion

Rita Elvas Ana , Lavrador Mariana , Melo Miguel , Barros Lui sa , Gomes Maria Leonor , Paiva Isabel

Introduction: Hypopituitarism is a rare entity that can have different aetiologies. Symptoms are usually progressive and non-specific; therefore, many patients are underdiagnosed and untreated. We present a clinical case of a patient presenting septic shock, hyponatremia and central hypothyroidism.Case report: A 46-year-old man was admitted in ICU for septic shock of unknown origin and multiorgan failure. Hormonal profile showed central hypothyroidism, p...

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ea0081ep811 | Pituitary and Neuroendocrinology | ECE2022

Non-functional pituitary adenomas: clinical and paraclinical aspects

Grassa Anis , Chehaider Cyrine , Khessairi Nadia , Yazidi Meriem , Oueslati Ibtissem , Chihaoui Melika

Introduction: Non-functional pituitary adenomas (NFPAs) represent 30% of all pituitary adenomas and not associated with clinical evidence of hormonal hypersecretion. The aim of our study was to describe the clinical and paraclinical aspects of NFPAs.Methods: This is a retrospective descriptive study concerning 40 patients who were hospitalized in the endocrinology department of Rabta hospital in Tunis between January 2014 and December 2020. Clinical and ...

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ea0081ep812 | Pituitary and Neuroendocrinology | ECE2022

Hypopituitarism induced Radiotherapy for nasopharyngeal carcinoma: a case report

Adel Meriem , Nacef Ibtissem Ben , Kamoun Elyes , Mekni Sabrine , Lakhoua Youssef , Mchirgui Nadia , Rojbi Imen , Khiari Karima

Introduction: Since the hypothalamic-puituitary axis (HPA) is a radiosensitive region, cranial radiotherapy for head and neck malignancies represents a major risk factor for the development of endocrine complications particularly hypopituitarism.Case report: A 22 years old girl with a history of a undifferentiated carcinoma of nasopharyngeal type UCNT at the age of 09 years old treated with radiotherapy and chemotherapy was referred to the endocrinology ...

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ea0081ep813 | Pituitary and Neuroendocrinology | ECE2022

Cushing Disease with COVID-19: Protective or Dangerous?

Yagmur Sahin Alak Zehra , Guller Pinar Uzgec , Burak Yaşar Mustafa , Guclu Metin , Aydemir Fatih , KIYICI Sinem

Introduction: Coronavirus disease-19 (COVID-19) pandemic renders high morbidity and mortality. Glucocorticoid excess is characterized by increased susceptibility to infections due to impairment of the innate and adaptive immune system. Manifestations of Cushing disease (CD) including diabetes mellitus (DM), hypertension, and obesity are risk factors for severe COVID-19 disease. We present three CD patients with different clinical courses of COVID-19. The patients general...

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ea0081ep814 | Pituitary and Neuroendocrinology | ECE2022

Exploring a new entity of monotherapy pembrolizumab-associated hypophysitis

Balti Eric , Verhaeghe Sarah , Kruse Vibeke , Roels Stijn , Coremans Peter

Background: There are increasing number of reports on immune checkpoint inhibitors induced adverse events including hypophysitis. Hypophysitis tends to occur more with CytotoxicT-lymphocyte-associated protein 4 inhibitors (12-15% of cases) which is a different entity compared to those associated to anti-program death 1 (anti-PD1) inhibitors.Aim: We describe a case of pembrolizumab-associated hypophysitis and conduct a discussion based on a systematic rev...

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ea0081ep815 | Pituitary and Neuroendocrinology | ECE2022

The impact of adenoma size on the clinical course of acromegaly : a comparative study

Akid Faten Haj Kacem , Belabed Wafa , Missaoui Abdelmouhaymen , Salah Dhoha Ben , Elleuch Mouna , Mnif Fatma , Mejdoub Nabila , Abid Mohamed

Introduction: Acromegaly is a chronic, slowly progressing disease caused in most cases by growth hormone (GH)- producing pituitary adenoma. This rare disorder is associated with a spectrum of various clinical manifestations and treatment outcomes differ between patients. The aim of this study was to evaluate the impact of adenoma size on comorbidities and biochemical status at the diagnosis of disease.Methods: This is a one-centre cohort study conducted ...

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ea0081ep816 | Pituitary and Neuroendocrinology | ECE2022

Clinical and demographic features of acromegaly in tunisian patients: a monocentric retrospective study

Akid Faten Haj Kacem , Belabed Wafa , Salah Dhoha Ben , Missaoui Abdelmouhaymen , Mnif Fatma , Elleuch Mouna , Mejdoub Nabila , Abid Mohamed

Background and Aims: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and distorted proportions. The objective of the current work was to investigate the clinical and demographic features of acromegaly in Mediterranean patients.Patients and Method: From 1997 to 2021, 29 patients with acromegaly were diagnosed and followed up...

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ea0081ep817 | Pituitary and Neuroendocrinology | ECE2022

Pituitary Stalk Interruption Syndrome in a 22-year old Filipino Male : A case report

Kei Bariuad-Garcia Irene , Paz Cecille Dela

Background: Pituitary Stalk Interruption Syndrome (PSIS) is a rare congenital anomaly affecting the pituitary gland with characteristic MRI findings of small or absent anterior pituitary gland, misplaced or absent posterior pituitary gland and very thin or interrupted pituitary stalk (1). Patients with PSIS often presents with signs and symptoms of either isolated growth hormone deficiency or multiple anterior pituitary hormone deficiency and symptoms differ according to age a...

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ea0081ep818 | Pituitary and Neuroendocrinology | ECE2022

Hypopituitarism in tropical countries

Ega Lakshman kumar , sahay rakesh , kudugunti neelaveni

Background: Etiology of hypopituitarism differs in tropical countries compared to the West and includes pituitary abscess, snake bite, HIV infection, Sheehan syndrome, road traffic accidents, iron overload states etc.Aims and Objectives: The present case series highlights the spectrum of hypopituitarism in tropical countries.Case Details: 1. C1: 23 y/o female presented with loss of consciousness, unrecordable BP and hypoglycemia. H...

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ea0081ep819 | Pituitary and Neuroendocrinology | ECE2022

Demonstration of the effects of asprosin on the sense of smell in female rats with hidden cookie test

Dila Oz Zeynep , Zorlu Go khan , Tan Fatih , Avcu Gaye Go ksu , Kacar Emine , Yasar Abdullah , Serhatlioglu Ihsan , Kelestimur Haluk , Yilmaz Bayram

Purpose: Asprosin is a novel glucogenic adipokine produced by the fibrillin 1 (FBN1) gene that is generated and released by white adipose tissue during fasting. Asprosin hormone has been shown to improve the sense of smell in wild-type mice by activating the OLFR734 receptor and decreasing the time it takes for them to discover hidden food. The purpose of this study was to determine the effects of asprosin on the sense of smell in female rats through the use of a hidden cookie...

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ea0081ep820 | Pituitary and Neuroendocrinology | ECE2022

Pre-validation study of alternative developmental neurotoxicity test using Sox1-GFP cell.

Kim YongIn , Jeong Sunhwa , Lee Jimin , Kim KangMin , Lee Minsu , Jeung Eui-Bae

The chemically induced disturbance during the neurodevelopment stage could cause a serious disease. In vivo study is useful to discriminate against neurotoxic substances but is time-consuming and ethically problematic. So, we have previously established, developmental neurotoxicity test (DNT) in vitro method using Sox1-GFP. In this study we aimed to increase the predictability of discriminant function. The equation was statistically improved using thirty addi...

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ea0081ep821 | Pituitary and Neuroendocrinology | ECE2022

Preference of acromegaly patients for treatment attributes in Spain

Fajardo-Montanana Carmen , Alvarez Escola Cristina , Biagetti Betina , Centeno Rogelio Garci a , Ciriza Raquel , Sanchez Laura , Diaz Marcos

Background: Acromegaly is a slowly progressive rare disease caused by an increase in growth hormone secretion that causes a subsequent rise in insulin-like growth factor (IGF-1), both contributing to the excessive growth of the extremities, soft tissues and organs, in addition to other comorbidities directly interfering with patients quality of life. Acromegaly patients are concerned about their disease and their treatments, however, publications about patients opi...

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ea0081ep822 | Pituitary and Neuroendocrinology | ECE2022

Sheehan Syndrome effects on cardiovascular risk

Salah Ameni , Maaroufi Amel , Ajili Rihab , Benabdelkarim Asma , Njah Maha Kacem , Hasni Yosra , Ach Koussay

Introduction: Sheehan syndrome has been for a long time the most frequent cause of hypopituitarism among women in developing countries, including Tunisia. Apart from hormonal deficits caused by SS, young women with SS are exposed to an increased risk of cardiovascular mortality. In this study, we aimed to evaluate the cardiovascular risk in patients with SS. Patients and methods This is a descriptive cross-sectional study. It was carried out in the Endocrinology department of ...

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ea0081ep823 | Pituitary and Neuroendocrinology | ECE2022

Prevalence of benign and malignant tumors in patients with acromegaly

Plotuna Iulia-Ştefania , Amzar Daniela-Georgiana , Balas Melania , Golu Ioana , Vlad Mihaela

Introduction: Acromegaly is an endocrine disease associated with an abnormal growth-hormone (GH) and insulin-like growth factor 1 (IGF-1) excess. Multiple studies demonstrated an association between these factors and pathways that play a major role in tumor proliferation, survival and resistance to anti-cancer therapies in many human malignancies.Objectives: We wanted to study the incidence and types of tumors which are associated with Acromegaly.<p ...

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ea0081ep824 | Pituitary and Neuroendocrinology | ECE2022

What factors predict a favorable response to hormonal therapy in congenital growth hormone deficiency?

Rekik Majdoub Nabila , ARBI Kawthar El , Zargni Asma , Salah Dhoha Ben , Benothman Wafa , Elleuch Mouna , Fatma Mnif , Charfi Nadia , Mnif Mouna , Akid Faten Haj Kacem , Abid Mohamed

Introduction: Growth hormone (GH) treatment in congenital growth hormone deficiency (CGHD) is indicated to improve the prognosis of the statural prognosis. The aim of this study is to identify the predictive factors of a favorable response to GH therapy.Patients & Methods: This is a retrospective study, conducted over a period of 27 years, including 30 patients with CGHD treated with hormonal therapy.Results: The CGHD was diagn...

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ea0081ep825 | Pituitary and Neuroendocrinology | ECE2022

Binasal hemianopsia with pituitary adenoma in a 15-year-old girl

Kamoun Elyes , Rojbi Imen , Mekni Sabrine , Smadhi Houaida , Lakhoua Youssef , Ben Nacef Ibtissem , Khiari Karima

Introduction: Pituitary adenomas represent 10 to 20% of intracranial tumors. In children, craniopharyngioma are the most common tumor of the sellar region. The symptoms can include headache, vomiting, pituitary deficiency and in pituitary adenomas, hormonal excess. The visual examination can find a visual field defect such as a bitemporal hemianopsia. We present a rare case of a pituitary adenoma in a 15-year-old girl with binasal hemianopsia.Observation...

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ea0081ep826 | Pituitary and Neuroendocrinology | ECE2022

Looking for a safe and effective drug: the troubled journey of a Cushing’s Disease patient

Milioto Angelo , Cocchiara Francesco , Corica Giuliana , Khorrami Keyvan , Nista Federica , Criminelli Diego , Zona Gianluigi , Ferone Diego , Gatto Federico

Cushings Disease (CD) is severe clinical condition due to an ACTH-secreting pituitary tumor. Here we present the case of a 25-years old male who came to our attention for hypertension, moon face, acanthosis nigricans, abdominal purple striae and central obesity. The diagnosis of CD was based on the presence of high plasma cortisol after dexamethasone suppression test and elevated urinary free cortisol levels (UFC, 6-fold higher the upper limit of normality (ULN)). The pi...

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ea0081ep827 | Pituitary and Neuroendocrinology | ECE2022

Management of SIADH in patients with acute admissions to hospital: a single centre experience

Shah Vinit , Neale Francesca , Condurache Dorina , Baleswaran Saranya , Price Amy , Seetho Ian

Background: Hyponatraemia is a common electrolyte abnormality that is associated with significant morbidity and mortality in patients admitted to hospital. Fluid restriction is the recommended treatment option for syndrome of inappropriate antidiuretic hormone secretion (SIADH), a common cause of hyponatraemia with limited evidence for alternative treatment options. The aim of our study was to share the experience of our hospital in the successful management of SIADH where we ...

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ea0081ep828 | Pituitary and Neuroendocrinology | ECE2022

The third case report of pituitary apoplexy complicated by a subarachnoid hemorrhage and ventricular extension

De Herdt Carlien , Niels Kamerling , Block Christophe De

Introduction: Pituitary apoplexy is a rare endocrine emergency due to hemorrhage of the pituitary gland. The clinical presentation depends on the extent of bleeding and can deteriorate into a life-threatening condition if complicated by a subarachnoid hemorrhage, as previously described in 2 cases.Case Description: A 60-year-old woman presented herself at the emergency department because of confusion for several hours. Clinical examination revealed aniso...

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ea0081ep829 | Pituitary and Neuroendocrinology | ECE2022

Hormonal and regional complications of craniopharyngomas

Faraoun Khadra , Farida Chentli

Background: The craniopharyngioma is a non-endocrine tumor, developed along the infundibulo-pituitary axis, from the 3rd ventricle to sphenoid, histologically benign but locally invasive. It is a tumor with serious complications because of its location, its considerable potential for extension, its tendency to recur, and its adhesions to neighbouring structures. Our aim is to assess hormonal, neuro-ophthalmological and metabolic complications at the diagnosis of cra...

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ea0081ep830 | Pituitary and Neuroendocrinology | ECE2022

‘Features of cardiovascular complications in patients with cushing syndrome in the republic of uzbekistan (register data)’

Jabborova Gavhar , Khalimova Zamira

The purpose of the study: Is to study features of cardiovascular complications in patients with Cushing syndrome in the Republic of Uzbekistan (RUz).Material and research methods: In the period of 2002 to 2021, 317 patients were installed with the following clinical forms of Cushing syndrome (CS): 1) ACTH-dependent CS (ACTH-DCS) - 258 (81.3%) patients, of which women -174 (54.8%), men - 84 (26.4%), 2) ACTH independent CS (ACTH-iCS) -51 patients (16.08%) ...

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ea0081ep831 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly in the elderly patients

Khelifi Dayssem , Khessairi Nadia , Terzi Ameni , Grira Wafa , Chihaoui Melika

Introduction: Pituitary adenomas in people over 65 represent less than 10% of all pituitary adenomas, 80% of which are non-functional. Somatotropic adenomas remain very rare. The interest of our study is to describe the clinical, paraclinical and therapeutic profile of cases of senile acromegaly.Patients and methods: This is a retrospective study of four senile acromegaly patients followed in our endocrinologys department.Res...

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ea0081ep832 | Pituitary and Neuroendocrinology | ECE2022

Features of the incidence of postoperative complications in patients with transsphenoidal pituitary adenectomy

Inomova Gulmira , Khalimova Zamira

Target: To study the incidence of postoperative complications in patients with transsphenoidal pituitary adenoectomy.Materials and research methods: 180 cases of PA subjected to T&Rcy;&Acy; for the period from 2018 to 2020 were analyzed. Of these, 102 (56.6) women, 78 (43.3) men, patients were divided into two alternative groups: the first group - 93 (51.6%) patients with macroadenomas - 42 (45.2%) men, women 51 (54.8%), the second (comparison group) - 8...

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ea0081ep833 | Pituitary and Neuroendocrinology | ECE2022

‘The frequency of postoperative hypopituitarism in patients with non-functional pituitary adenomas (NFPA) after transnasal hypophysectomy’

Mirtukhtaeva Malika , Yulduz Urmanova

The purpose of the study: is to study the frequency of postoperative hypopituitarism after transnasal hypophysectomy (THE) in patients with pituitary adenomas.Material and methods: Under our observation there were 24 patients with NFPA, of whom women were 14, men - 10. The average age of patients was 36.4 years. Total of 24 patients were performed for the period from 2016 to 2021 33 surgery in the neurosurgery department., of which THE - 32, 1 - bifronta...

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ea0081ep834 | Pituitary and Neuroendocrinology | ECE2022

‘Case of re-growth of aggressive giant non-functional pituitary adenoma with panhypopituitarysm in 28-years old woman’

Yulduz Urmanova , Mirtukhtaeva Malika

The purpose of the study: Is to research case of re-growth of non-functional giant pituitary adenoma (NFPA) with panhypopituitarysm in 28-years old womanMaterial and research methods: Patient Karimova N, was born in 1994 in Namangan region. Clinical diagnosis: Non-functional giant pituitary adenoma with total variant of growth. Status after transnasal selective adenomphysisectomy (12.04.16). Re-growth of tumor. Second transnasal selective adenomphysisect...

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ea0081ep835 | Pituitary and Neuroendocrinology | ECE2022

Cushing syndrome and disease: A doctor of philosophy study conducted by a patient

McBride Margaret

Introduction: Prior to and since the onset of my Doctorate study in 2019, a plethora of on-going research including my own has been conducted into the diagnosis, treatment, and management of Cushing syndrome (CS), and disease (CD). These conditions continue to challenge physicians not only in the diagnosis but how to treat their patients. The wide clinical spectrum of CS and CD produces a medical dilemma as patients symptoms, can vary. The typical Cushingoid features whi...

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ea0081ep836 | Pituitary and Neuroendocrinology | ECE2022

Metabolic abnormalities profile of non-functioning pituitary adenomas

Abdellaoui Wahiba , Assarrar Imane , Zarraa Lamiae , Berrabeh Soumiya , Rouf Siham , Latrech Hanane

Introduction: Metabolic abnormalities are common in pituitary adenomas and metabolic targeting is becoming a new therapeutic approach to the management of most tumor pathologies, especially pituitary tumors. The objective of this work was to assess the metabolic profile of non-functioning pituitary adenomas.Material and methods: A retrospective and descriptive study, over a period of 6 years, conducted in the Endocrinology-Diabetology and Nutrition depar...

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ea0081ep837 | Pituitary and Neuroendocrinology | ECE2022

Kallmann’s Syndrome: case report

Aziz Rokya Abdel , Moustafa Heba , Sultan Soad , Salam Randa , Garhi Ola El , Tohamy Iman , Taraby Aya , Nashat Amira

Introduction: Kallmann syndrome, a rare genetic disorder, refers to the association between hypogonadotropic hypogonadism and anosmia or hyposmia due to abnormal migration of olfactory axons and gonadotropin-releasing hormone producing neurons It can be autosomal dominant, autosomal recessive, or X-linked inheritance.Case report: A 16-year-old male student, presented to endocrinology unit with delayed puberty. He was born to consanguineous parents and ha...

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ea0081ep838 | Pituitary and Neuroendocrinology | ECE2022

‘The functional status of pituitary-gonads-cortex axis in women on fertile age with ACTH-depended Cushing syndrome’

Khalimova Zamira , Irgasheva Oydin

Aim: to study the functional status of pituitary-gonades-cortex (PGC) axis in women with Cushing syndrome (CS)Materials and methods: Weevaluated 25 women with ACTH-depended CS without other associated pathology. Mean age of patients was 28,3 years-old\. All patients have complaints to amenorrhea and primary infertility. Control group constituted by 20 healthy women with same age All patients underwent clinical and biochemical evaluations including...

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ea0081ep839 | Pituitary and Neuroendocrinology | ECE2022

Diagnosis of Kallmann syndrome in adulthood

Kamoun Elyes , Mekni Sabrine , Adel Meriem , Rojbi Imen , Ben Nacef Ibtissem , Mchirgui Nadia , Khiari Karima

Introduction: Kallmann syndrome is a rare genetic condition characterized by the association of a hypogonadotropic hypogonadism and anosmia. It results from the failure of GnRH cells to migrate to the hypothalamus and lack of development of the olfactory bulb. The main symptom of Kallmann syndrome is delayed or incomplete puberty usually associated with an impaired sense of smell. We herein describe a case of Kallmann syndrome discovered at the age of 57 years old.<p class...

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ea0081ep840 | Pituitary and Neuroendocrinology | ECE2022

Evaluation of neuroendocrine dysfunction in the diagnosis of depressive and non-depressive alcohol-dependent persons

Guha Shaibal , Shankar Anand , Das Amit Kr , Kumar Subhash

Introduction: Acute and chronic alcohol intake and alcohol withdrawal induce dysfunction of neuroendocrine and other regulatory systems. The expression neuroendocrine dysfunction alludes to an assortment of conditions brought about by imbalances in the bodys chemical creation straightforwardly connected with the pituitary, nerve center, and their tomahawks following TBI.Aims: This study aimed to assess a possible hypothalamo-pituitary-a...

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ea0081ep841 | Pituitary and Neuroendocrinology | ECE2022

Descriptive study of the acromegaly disease activity according to ACRODAT® in a tertiary Hospital in Spain

Carlos Percovich Hualpa Juan , Anez Roberto , Centeno Rogelio Garci a , Fernandez Laura Gonzalez , Munoz Diego , Montenegro Alejandra Maricel Rivas , Fernandez Fernandez Elisa , Guerrero Crystal , Gonzalez Albarran Olga

Background: The goals of acromegaly treatment are to achieve long-term biochemical control, control tumor size and decrease the risk of developing systemic comorbidities. Moreover, from the patients perspective, symptoms and QoL are critical parameters of disease control and should be assessed routinely. To aid in the global clinical management of acromegaly, a holistic clinical decision support tool, the Acromegaly Disease Activity Tool (ACRODAT®) was developed.</p...

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ea0081ep842 | Pituitary and Neuroendocrinology | ECE2022

Central precocious puberty in a young boy associated with bilateral optic pathway glioma in neurofibromatosis Type 1: a case report

Saleem Muhammad , Farooq Saad , Ulhaq Imran

Background and Importance: Precocious puberty refers to sexual characteristics development before the normal age for its development. Neurofibromatosis Type 1 is an autosomal dominant condition with wide spectrum of clinical phenotype of which precocious puberty is common. This case report highlights the importance of recognizing this disease in patient presenting with precocious puberty and screening for optic pathway gliomas should be done and treat it to prevent the future ...

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ea0081ep843 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly-related dysmorphic syndrome In Mediterranean Patients: A monocentric retrospective Survey

Akid Faten Haj Kacem , Belabed Wafa , Mouna Elleuch , Chehaidar Cyrine , Salah Dhoha Ben , Mnif Fatma , Mejdoub Nabila , Abid Mohamed

Background and Aims: Acromegaly is an insidious disease related to hypersecretion of growth hormone (GH) that leads to several cardiovascular, respiratory, and metabolic comorbidities. The onset of dysmorphic body changes is one of the earliest signs of this condition. The objective of the current work was to describe the clinical manifestations of dysmorphic modifications characterizing Mediterranean patients diagnosed with acromegaly.Patients and Metho...

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ea0081ep844 | Pituitary and Neuroendocrinology | ECE2022

Cushing’s disease in a 14 year old child: A real diagnostic and therapeutic challenge

Souleima Trigui , Najoua Lassoued , Houcem Mrabet , Fedia Boubaker , Wafa Alaya , Hbib Sfar Mohamed

Introduction: Cushings disease (CD) is a rare but serious pathology in children and adolescents. It differs from adult pathology by the mode of presentation and management. We report a case of CD in a 14-year-old child whose diagnosis was confirmed only after 2 years.Observation: This was a 14-year-old female patient with a family history of consanguineous marriage and personal history of nephrotic syndrome who presented with delayed stature, delay...

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ea0081ep845 | Pituitary and Neuroendocrinology | ECE2022

Clinical, biological and radiological particularities of acromegaly: Experience of the Endocrinology Department of the EPH Bologhine of West Algiers

Bouzid Aicha , Kherrab Hanane , Djamila Meskine , Azzouz Malha

Introduction: Acromegaly is caused by chronic hypersecretion of GH and IGF-1. Chronically elevated GH and IGF-1 levels lead to a complex spectrum of signs.Objectives: To describe the clinical, hormonal and radiological profile of acromegaly at the time of diagnosis.Materials and methods: Retrospective study including 67 patients hospitalized in the Endocrinology Department of the EPH BologhineResults: There w...

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ea0081ep846 | Pituitary and Neuroendocrinology | ECE2022

Case report: Kallmann syndrome associated with a non-functional pituitary microadenoma

Bammou Sanaa , Rafi Sana , MGHARI Ghizlane EL , ANSARI Nawal EL

Introduction: Kallmann syndrome (KS) is a rare disorder. It is now designated as olfactogenital dysplasia with an association between agenesis of the olfactory bulbs and hypogonadism. The association of KS with a pituitary microadenoma has not been well described in the literature.Case report: Its a 16-year-old and 6 months, admitted for evaluation of a micropenis, he has as ATCDs an orchidopexy performed at the age of 3 years, infertility in the m...

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ea0081ep847 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly revealed by pituitary apoplexy : a case report About 2 cases

Bouzid Aicha , Kherrab Hanane , Djamila Meskine , Azzouz Malha

Introduction: Pituitary apoplexy is a rare endocrine emergency that can occur due to pituitary infarction or hemorrhage. There are conflicting data regarding the type of pituitary adenoma prone to apoplexy. Prolactinomas seem to have the highest risk. We report 2 cases of apoplexy of a somatotropic adenoma not medically treatedCase 1: Patient aged 45 years, with a history of chronic headaches, hospitalized in the emergency room for management of a mening...

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ea0081ep848 | Pituitary and Neuroendocrinology | ECE2022

Chronic diarrhea: the diagnostic process

Floroskoufi Paraskevi , Vourlioaki Eirini , George Papazoglou , Koukias Stergos , Stamataki Aikaterini

Introduction: Neuroendocrine tumors (NETs) are a heterogeneous group of rare neoplasms that originate from endocrine cells with the ability to secrete amines and hormonal polypeptides. Pancreatic neuroendocrine tumors (PNETs) can be functional or non-functional. Functional PNETs secrete common hormones such as gastrin, insulin and glucagon and much less frequent hormones such as vasoactive intestinal peptide (VIP). Their clinical characteristics depend on the peptide secreted....

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ea0081ep849 | Pituitary and Neuroendocrinology | ECE2022

Features of a clinical flow and diagnostics of patients with the family anamnesis of inactive adenomas of hypophysis (IAH)

Xolova Dilorom

Objective was to study features of clinical semiology, their value for differential diagnostics in population of patients with the sporadic and family IAH anamnesis.Materials and methods.: 71 IAH patients with intracellar adenoma of a hypophysis. Patients with IAH were divided into two alternative groups: the 1st group - 50 (70,4 %) patients with environmental factors without the burdened family anamnesis and 2nd - 21 (29,6 %) with the burdened family an...

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ea0081ep850 | Pituitary and Neuroendocrinology | ECE2022

Polyuro-polydipsia syndrome revealing a craniopharyngioma in a 60-year-old female patient following a surgery

Mhamdi Zineb , Amira Ikram , Rifai Kaoutar , Iraqi Hinde , El Hassan Gharbi Mohamed

Introduction: Craniopharyngioma is a benign, slow-growing epithelial tumor of embryonic origin, originating in the pituitary stem or pituitary gland and developing in the sellar and/or suprasellar region. It is characterized by its considerable potential for extension, its tendency to recur, and its adhesions to surrounding structures.Case report: We report the case of a 60-year-old female patient with secondary amenorrhea at the age of 38 years, neglect...

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