Endocrine Abstracts

Introduction: Publications suggesting that thyroid nodules might be associated with insulin resistance (IR) and metabolic syndrome are quite interesting. The aim of the work is to analyze the association between anthropometric indicators IR and insulin-like growth factor-1 (IGF-1) in patients with nodular goiter. Methods Examined 73 patients with euthyroid single-node (n=34) and multinodular goiter (n=39), age (51.0±10.6) years; determining WC, WC/HC, BMI, WHtR, ABSI, BFD, BRI, CI, AVI, BAI, IGF-1. Thyroid volume, its structure, number, size, and location of foci were assessed by an ultrasonic complex.

Results: In the total group IGF-1 is associated with BMI (r= -0.30; P=0.016), WC (r= -0.26; P=0.036), WHtR (r= -0.30); P=0.020), AVI (r= -0.27; P=0.03), ABSI (r= -0.31; P=0.015), BFD (r= 0.27; P=0.033)), BRI (r= 0.29; P=0.02) and BAI (r= 0.36; P=0.004); thyroid volume is associated with age (r= 0.35; P=0.009), WC/HC (r= 0.43; P=0.001), BFD (r= 0.26; P=0.06) and CI (r= 0.31; P=0.02). In patients with BMI≥35 kg/m² thyroid volume is associated with BMI (r= 0.71; P=0.049). In patients with IGF-1 above the sex-age norm, thyroid volume is associated with WC/HC (r= 0.71; P=0.01), BAI (r= 0.66; P=0.03) and BFD (r= -0.52; P=0.01). It has been found that BAI explains 82.37% of the variance of IGF-1 in the general group and more than 90% of the variance of its level in groups of patients with nodular goiter with high IGF-1 with/without obesity. ConclusionPatients with nodular goiter with IGF-1 above the sex-age norm have significantly higher values of anthropometric indicators IR compared with patients with a normal level of this indicator. In patients with obesity, thyroid volume is significantly associated with BMI. BRI (R²=81.14%) is a predictor of increased thyroid volume in patients with IGF-1 high levels and obesity.