Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

ea0081ep944 | Thyroid | ECE2022

Tension-free thyroidectomy (TFT) may reduce the complication rate in thyroid surgery: experience of the first 120 cases

Sleptsov Ilya , Chernikov Roman , Sablin Ilya , Pushkaruk Alexander , Fedotov Yuri

Background and aims: The safety of thyroid surgery in terms of recurrent laryngeal nerve palsy and hypoparathyroidism was increasing in the last decade. In this study, we present a new method of tension-free thyroidectomy (TFT), which could be used to further decrease the complication rate after thyroidectomy.Patients and Methods: TFT is based on the medial approach to the recurrent laryngeal nerve (RLN) and the parathyroid glands after the division of i...

ea0081ep945 | Thyroid | ECE2022

Radiofrequency ablation for benign thyroid nodules of 650 patients: long-term follow-up

Solovov Vyacheslav , Ablekova Olga

Purpose: The objective of this study was to evaluate the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treating of benign thyroid nodules both autonomously functioning thyroid nodules (AFN) and symptomatic ones.Material and Methods: The retrospective analysis included the results of treatment of 650 patients with benign tumors of the thyroid gland in the Samara Oncology Center since 2014 year. 182 (28 %) patients had aut...

ea0081ep946 | Thyroid | ECE2022

Decrease the functional activity of adaptive immunity cells one month after radioiodine therapy for Graves’ diseaseDecrease the functional activity of adaptive immunity cells one month after radioiodine therapy for Graves’ disease

Savchenko Andrey , Dudina Margarita , Dogadin Sergey A. , Borisov Alexandr , Fomina Daria , Belenyuk Vasiliy

Introduction: Radioactive iodine (RAI) for Graves’ disease (GD) was reported to have specific immune effects. The ability of T and B lymphocytes to cooperatively interaction during the immune response may be impaired in GD patients eligible for RAI therapy. We aimed at investigating cellular subsets involved in functional activity of adaptive immunity cellsone month after RAI therapy in patients with GD.Materials and methods: Thirty-six women with G...

ea0081ep947 | Thyroid | ECE2022

Myocardial Ischemia precipitating thyroid storm diagnosed during storm recovery through Wellen’s wave: An ECG for an eye

Patra Shinjan , Roy Ayan , Priya Anu , Kaushik Atul

Introduction: Thyroid storm is a major life-threatening condition in a patient of thyrotoxicosis which can precipitate the cardiovascular morbidity in forms of tachycardia, arrythmia and congestive heart failure. It can be precipitated by acute coronary syndrome. Most literatures have reported acute coronary syndromes during the presentation itself but we describe an unique case where the diagnosis was possible after the resolution of the thyroid storm.C...

ea0081ep948 | Thyroid | ECE2022

Immune checkpoint inhibitors induced myxedema coma

Sebile Dokmetaş Hatice , Dokmetaş Meric , Bayramgil Ayberk , Karaipek Ku bra , Dorukhan Cavuşoğlu Guneş , Temiz Cansu , İdrisoğlu Cem , Kılıclı Fatih , Bilici Ahmet

Introduction: Myxedema coma is very rare and its mortality is quite high. It is even rarer to occur due to an immune checkpoint inhibitor.Case: A 69-year-old patient presented with complaints of dyspnea, fatigue, edema, and hypotension. He had diabetes mellitus, hypertension, and metastatic lung cancer diagnosis. Three weeks ago, he had taken the 10th cycle of atezolizumab for lung cancer, which he had been taking for 7 months. The patient’s body te...

ea0081ep949 | Thyroid | ECE2022

Subacute thyroiditis in patients after COVID-19 infections at the outpatient stage

Shyshko Volha , Malakhava Darya , Yurenia Alena

Introduction: SARS-COV-2 is a new infection with little known consequences. As data accumulated, it became known that the thyroid gland is also affected as a result of infection. During the reconvalescence period, some patients developed severe thyrotoxicosis, which did not have the classic clinical picture of subacute thyroiditis or autoimmune.Aim: To study the course of subacute thyroiditis in patients after infection with COVID-19.<p class="abstex...

ea0081ep950 | Thyroid | ECE2022

Therapeutic plasmapheresis to induce euthyroidism prior to thyroidectomy

Mee Cheng Wee , Kuan YC

Use of therapeutic plasmapheresis in hyperthyroidism is mainly described in thyroid storm when traditional measures fail. Patients with hyperthyroidism who respond poorly or suffer adverse effects to conventional antithyroid therapies, which then need to be stopped, can have persistently high levels of thyroxine and at risk of a full blown thyroid storm. Hence an alternative treatment to achieve euthyroidism followed by thyroidectomy as definitive therapy is vital. We report h...

ea0081ep951 | Thyroid | ECE2022

Ocular manifestations of Graves’ disease

Sonda Kammoun , Mona Rekik , Sofien Affes , Akid Faten Haj Kacem , Saloua Ben Amor , Amira Trigui

Introduction: Graves’ ophthalmopathy, also called Graves’ orbitopathy, is a potentially sight-threatening ocular disease that has puzzled physicians and scientists for nearly two centuries. Generally occurring in patients with hyperthyroidism or a history of hyperthyroidism due to Graves’ disease, Graves’ ophthalmopathy is also known as thyroid-associated ophthalmopathy or thyroid eye disease, because it sometimes occurs in patients with euthyroid or hypoth...

ea0081ep952 | Thyroid | ECE2022

Thyroid-associated orbitopathy exacerbation following COVID-19

Saafi Wiem , Saad Ghada , Elfekih Hamza , Allegue Sinda , Maaroufi Amel , Kacem Maha , Chaieb Molka Chadli , Hasni Yosra , Ach Koussay

Introduction: Thyroid-associated orbitopathy is an autoimmune disease of the retroocular tissues commonly associated with Graves’ disease (GD) and rarely reported in Hashimoto’s thyroiditis (HT). GD and HT are autoimmune thyroid disease which are sometimes hard to distinguish from one another and their association in one person is rarely described. Here, we report a case of an exacerbation of thyroid-associated orbitopathy in a patient with GD following a SARS-CoV-2 ...

ea0081ep953 | Thyroid | ECE2022

Risk of malignancy of indeterminate thyroid nodules: an Italian single-center cohort study

Cera Gianluca , Novizio Roberto , Corsello Andrea , Rossi Esther Diana , Locantore Pietro , Pontecorvi Alfredo

Background: In 2014 a new Italian classification system of thyroid cytology divided the indeterminate TIR3 category in two groups, TIR3A and TIR3B, aiming to reduce unnecessary thyroidectomies. The reported risk of malignancy is: TIR3A: <10%, suggesting follow-up and possible FNA repetition after 6 months, and TIR3B: 15-30%, recommending surgery.Objectives: We aimed to: evaluate the histological prevalence of malignancy in TIR3A and TIR3B nodules in ...

ea0081ep954 | Thyroid | ECE2022

The level of neutrophil reactive oxygen species in euthyroid and relapse patients with Graves’ hyperthyroidism

Dudina Margarita , Savchenko Andrey , Dogadin Sergey A. , Gvozdev Ivan

Introduction: Graves’ disease (GD) is organ-specific autoimmune-inflammatory disorder characterized by a complex pathogenesis. The inflammatory process is dominated by an imbalance of the antioxidant-oxidant mechanism, increased production of reactive oxygen species (ROS), which can potentiate the cytotoxicity of neutrophils and sustain the autoimmune process and perpetuate the disease. Aim: to study the level of ROS synthesis by peripheral blood neutrophils in patients w...

ea0081ep955 | Thyroid | ECE2022

Association between hyperthyroidism caused by Graves’ disease and subjective sleep disorders

Matsumoto Kazuhisa , Izawa Shoichiro , Fukaya Kenji , Matsuda Eriko , Fujiyama Misato , Matsuzawa Kazuhiko , Okura Tsuyoshi , Kato Masahiko , Taniguchi Shin-ichi , Yamamoto Kazuhiro

Background and objective: Sleep disorders (SDs) are classified into subjective and objective SDs, and subjective SDs are directly related to quality of life. According to previous studies, Graves’ disease (GD) causes SDs, especially insomnia. However, the characteristics of subjective SDs and its clinical course after hyperthyroidism normalization remain unclear. Additionally, the factors involved in subjective SDs with hyperthyroidism in GD remain unclear. Hyperthyroidis...

ea0081ep956 | Thyroid | ECE2022

Dosing study of brand vs. generic levothyroxine in well-controlled primary hypothyroidism

Kamoun Elyes , Jemel Manel , Gharbi Radhouen , Mkaouer Samir , Kandara Hajer , Kammoun Ines

Introduction: Most brand-name drugs do not differ that much from their generic counterparts, so switching between the two is not an issue. Levothyroxine, however, is an exception. The question of generic equivalency of levothyroxine products has remained unanswered for several decades. The purpose of the present study was to learn whether there is a difference of dosage between brand-name and generic levothyroxine in patient with well controlled primary hypothyroidism<p cl...

ea0081ep957 | Thyroid | ECE2022

Did well-controlled hypothyroid patients have necessary good compliance?

Kamoun Elyes , Jemel Manel , Gharbi Radhouen , Hilel Wafa Ben , Kandara Hajer , Kammoun Ines

Introduction: Treatment of primary hypothyroidism relies on a daily intake of levothyroxine, which dosage is determined first by the weight then by TSH levels monitoring. The daily dosage can vary with the cause of the hypothyroidism and the weight. The aim of our study was to determine if the adherence was a factor influencing the dosage of levothyroxine in a group of well-controlled hypothyroid patients.Method: We performed a cross-sectional study incl...

ea0081ep958 | Thyroid | ECE2022

Immunogenetic aspects of polyglandular autoimmune syndrome

Mnif Fatma , Soomauroo Siddiqa , Belabed Wafa , Fourati Hajer , Missaoui Abdelmouhaymen , Salah Dhoha Ben , Elleuch Mouna , Rekik Nabila , Abid Mohamed

Introduction: Polyglandular autoimmune syndrome (PAS) are uncommon constellations of autoimmune diseases characterized by the occurrence of two or more auto-immune endocrine diseases in the same individual.Patients and methods: It is a case-control study about 108 cases for 120 healthy subjects recruited as the control group. We aimed to study the polymorphism of the HLA class-II genes of patients compared to that of healthy subjects so as to identify th...

ea0081ep959 | Thyroid | ECE2022

Graves’ orbitopathy caused by alemtuzumab: a case series

Mendez Muros Mariola , Jesus Garcia Gonzalez Juan , Cuadrado Alberto Torres , Manuel Garrido Hermosilla Antonio

Introduction: Alemtuzumab is a monoclonal antibody targeting the CD52 glycoprotein, which is expressed by most mature leucocytes. In early relapsing-remitting multiple sclerosis (MS) alentuzumab effectively decreases relapse rate and disability progression. However, nearly 50% of the pacients treated with alentuzumab develop secondary autoimmune disorders, being Graves’ disease the most common. The development of thyroid eye disease is unusual.Aims ...

ea0081ep960 | Thyroid | ECE2022

Euthyroid sick syndrome as a prognostic marker in patients with SARS-CoV-2 infection

Estevens Joana , Santos Liliana R. , Nunes Daniel , Lemos Carlos , Soares Paula , Pais de Lacerda Antonio

After almost 3 years since SARS-CoV-2infection was detected for the first time, knowledge about its repercussions on the thyroid gland function in the course of acute illness or in the post-COVID-19 are still poorly understood. This gland may be particularly susceptible to SARS-CoV-2 as this coronavirus enters cells through ACE-2 receptors, which are largely expressed in the thyroid gland. Through an observational, longitudinal and retrospective study, we investigated the seru...

ea0081ep961 | Thyroid | ECE2022

Use of thyroid hormone in hypothyroid and euthyroid patients. the THESIS questionnaire survey in spain

Carlos Galofre Juan , Attanasio Roberto , Hegedus Laszlo , Nagy Endre V. , Negro Roberto , Papini Enrico , Perros Petros , Diez Juan Jose

Background: Hypothyroidism is one of the most frequent conditions in endocrinology. Despite of that fact, indications for treatment differ among specialists in Spain.Aims: To identify attitudes of Spanish endocrinologists in the use of levothyroxine (LT4) therapy and the management of hypothyroidism.Methods: The members of the Sociedad Española de Endocrinología y Nutrición (Spanish Society of Endocrinology ...

ea0081ep962 | Thyroid | ECE2022

Substitution with combined vitamins and minerals will provide a sufficient level of iodine during pregnancy

Trifonova Boyana , Borissova Anna-Maria , Dakovska Lilia , Michaylova Eugenia

In 2005, the evaluation of an international expert group* placed Bulgaria among those who successfully overcame the problem of ‘iodine deficiency’. The aim of the study is to assess the current iodine status in pregnant women in two main regions of Bulgaria - with a known iodine deficiency and other with sufficiency in the past.Material: A cross-sectional multicenter population-based study was conducted in a total of 84 settlements from the two...

ea0081ep963 | Thyroid | ECE2022

The relationship between thyroid hormones and different degrees of obesity; a case-control study

Qasim Bayar , Mohammed Ayad , Ahmed Mazyar

Background: Obesity is a serious health problem worldwide and is caused by a wide variety of etiologies. There are several hormones which have been proved to be associated with increased body weight and has a direct effect on the fat metabolism like thyroid hormones.Methods: This is a case control study which included 384 adult persons, they were divided into 2 groups according to the thyroid function status, the first group included 204 apparently healt...

ea0081ep964 | Thyroid | ECE2022

Therapeutic approach to the diagnosis of Bethesda 5

Barrera-Martin Ana , Rosa Alhambra Exposito Mª , Moreno-Moreno Paloma , Angeles Galvez Moreno Maria

Introduction: Thyroid nodules are very common in the general population (20-75% ultrasound). There are clinical management criteria established by international societies and standardized cytological diagnostic criteria (Bethesda). However, there is still uncertainty in the management of category 5.Objectives: To evaluate the clinical attitude to the cytological diagnosis of Bethesda category 5 (B5) in thyroid fine-needle aspiration cytology (FNA). And s...

ea0081ep965 | Thyroid | ECE2022

An unusual pathology in graves’ Disease

Burhan Sebnem , Uzman Rukiye Dilara Tekin , Aksoy Ş eyma , Mert Doğukan Fatih , Şuheda Hatipoğlu Esra

Introduction: Graves disease (GD) is an autoimmune disease in which thyrotropin receptor antibodies overactive the thyroid gland. Therefore, antithyroid drugs, radioactive iodine therapy, or surgical interventions are treatment options. In GD, pathology after thyroidectomy may include hypertrophy and hyperplasia in thyrocytes, mononuclear cell infiltration in the stroma, and increased blood supply. We presented a case with areas of necrosis and vasculitis due to GD in the path...

ea0081ep966 | Thyroid | ECE2022

Radiofrequency thermal ablation (RFA) of Thyroid nodules: our initial experience

Jung Rachele Mattarello Mee , Mingardi Roberto , Santi Francesca De , Mazzucco Mauro

In recent years, US-guided thermal ablation techniques have been proposed as a therapeutic alternative to traditional surgery or to metabolic radiotherapy for thyroid nodes. RFA is one of the most used technique and experience in both ultrasound and ultrasound interventional is important for results and minimizing complications. We present our experience after 1 year of activity on the first 33 patients with thyroid nodules treated with RFA. The nodules were evaluated by ultra...

ea0081ep967 | Thyroid | ECE2022

Association between selected serum inflammatory parameters, low FT3 and mortality in hospitalized patients with COVID-19 - single center observation

Młodożeniec Aleksandra , Orłowska-Florek Renata , Czarnożycka-Wrobel Adrianna , Szul Paulina , Gargasz Krzysztof , Gala-Bladzinska Agnieszka

Introduction: The incidence and mortality rate for COVID-19 differ in different regions, but the risk of in-hospital death is high in all countries. It is very important to identify patients at risk of death at the beginning of hospitalization. The disease often leads to NTIS (nonthyroidal illness syndrome), which can be the result of the cytokines storm [1]. The inflammatory parameters and the level of FT3 appear to be obvious leading risk of death.Obje...

ea0081ep968 | Thyroid | ECE2022

Thyrotoxicosis and multisystemic inflammatory syndrome in a patient with recent history of COVID-19

Cristiana Calin , Ioana Iulia Greere Daniela , Burcea Iulia Florentina , Poiana Catalina

Introduction: There is evidence on the association of subacute thyroiditis (SAT) and SARS-CoV-2 infection, the first case report being described in a young woman back in July 2020 (1). Multisystemic inflammatory syndrome in adults (MIS-A) is a rare complication of SARS-CoV-2, usually 2 to 12 weeks after initial infection. The development of Graves disease after SAT is rare, with approximately 31 reported cases, of which only 5 occurring in men (2). We pre...

ea0081ep969 | Thyroid | ECE2022

A rare case of symptomatic amyloid goiter diagnosed by tru-cut biopsy

Hocaoglu Erhan , Aydemir Ensar , Ates Coskun , Saridas Filiz Mercan , Cander Soner , Gul Ozen Oz , Ersoy Canan , Erturk Erdinc

Introduction: Amyloid goiter is a rare entity caused by massive amyloid infiltration of the thyroid gland. In some cases, differential diagnosis can be challenging. In this report, we present a patient with amyloid goiter caused by secondary amyloidosis.Case: A 48-year-old male patient was admitted to our hospital with the complaints of neck swelling, pain, and mild dysphagia that started three weeks after the SARS-Cov-2 infection and continued for one m...

ea0081ep970 | Thyroid | ECE2022

Autoimmune thyroid disorders and connective tissue disease

Salah Raida Ben , Akid Faten Haj Kacem , Soomauroo Siddiqa , Mohamed Ahmed Mohamed Abdellahi , Chouaib Sarra , Frikha Faten , Rekik Nabila , Abid Mohamed , Bahloul Zouheir

Introduction: Mixed connective tissue disease (MCTD), also known as Sharp´s syndrome is a rare autoimmune disease (AD), characterized by the presence of high titers of a distinctive autoantibody: ribonucleoprotein auto-antibody (anti-RNP). It presents with varied overlapping symptoms of different connective tissue disorders which may appear sequentially over time. As other AD, MCTD may be associated with one or more AD, such as autoimmune thyroid disorders (AITD).<p c...

ea0081ep971 | Thyroid | ECE2022

Hypovitaminosis D and Hashimoto’s thyroiditis: effects of four-month supplementation therapy with oral cholecalciferol

Villa Alice , schiavo anna , Volpe Maria Gabriella , Sansone Andrea , Romanelli Francesco

Background: Hypovitaminosis D represents at present a worldwide public health problem. Recent studies have demonstrated the pleiotropic effects of vitamin D, in addition to its known actions on calcium-phosphorus metabolism. Among the several non-skeletal effects, a potential anti-inflammatory and immunomodulatory action has been suggested. Vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune...

ea0081ep972 | Thyroid | ECE2022

Unilateral graves’ disease : a case report

Khiari Hager , Mekni Sabrine , Adel Meriem , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Nacef Ibtissem Ben , Khiari Karima

Introduction: Graves disease is a frequent etiology of hyperthyroidism. It is defined as a diffuse hyperfunctioning of the thyroid gland caused by an autoimmune disorder. We herein present a rare case of unilateral Graves disease involving the right lobe of the thyroid.Observation: A 44-year-old woman was referred for investigation of subclinical hyperthyroidism revealed by a routine check-up. On physical examination, she had tremor, eyelid retraction, t...

ea0081ep973 | Thyroid | ECE2022

Hyperthyroidism revealing thyroid heterotopia

Chaimae Kadiri , Hassan Lachkar

Introduction: Thyroid heterotopia is an abnormal location of coexisting normal thyroid tissue with a normal organ and normal location. It is a congenital anomaly due to a defect in the maturation of the thyroid tissues, which is distinguished from ectopic thyroid and from a thyroid cancer metastasis.Observation: We report the case of a 65-year-old patient, with no notable history, who consulted for clinical signs of thyrotoxicosis associating asthenia, t...

ea0081ep974 | Thyroid | ECE2022

Cervicomediastinal thymic cyst mimicking thyroid : A case report

Malika El Omri , Mallat Amany , Njima Marwa Ben

Introduction: Cervical thymic cysts are among the rarest congenital neck masses. Thymic migration into the superior mediastinum during organogenesis explains the topography and diversity of clinical presentations of these cysts. Due to the possibility of mediastinal extension, the management of these lesions is different than other congenital neck masses. The aim of our work is to present the clinical, radiological, and therapeutic features of cervicomediastinal thymic cysts.<...

ea0081ep975 | Thyroid | ECE2022

Correlation between thyroid nodules cytologies applying the Bethesda System with post-thyroidectomy histopathological diagnosis

Mola Reyes Laura , Herraiz Carrasco Lorea A. , Arroba Cristina Martin-Arriscado , Kanaan Laura Kanaan , Manchado Teresa De Grado , Penso Espinoza Rona H. , Crespo Hernandez Irene , Elena Mendoza Sierra Maria

Introduction: Thyroid nodules represent a common cause of specialist consultation, with a risk of malignancy of 4-15%. The most widely used cytopathological method for diagnosing thyroid cancer is fine-needle aspiration biopsy (FNAB) of thyroid nodules and the use of the Bethesda system (BS) for cytopathological reporting. We conducted the present study to report our experience using the BS, and to compare the results obtained with this system with the final histopathological ...

ea0081ep976 | Thyroid | ECE2022

Anaplastic thyroid carcinoma: about 7 cases

Chebil Ezer , Sameh Jebahi , Wadie Thabet , Mahdi Hassnaoui , Khlifa Mighri

Introduction: Anaplastic thyroid cancers are undifferentiated malignancies accounting for 2% of thyroid cancers.Objective: To study the clinical, evolutionary and therapeutic characteristics of these carcinomas.Materials and methods: A retrospective study covering 7 cases collected at our ENT department between 1994 and 2021.Results: They were 6 women and one man with an average age of 50 (41-78). The reason ...

ea0081ep977 | Thyroid | ECE2022

Radiofrequency thermal ablation for a small papillary thyroid carcinoma: a case report

Jung Rachele Mattarello Mee , Santi Francesca De , Mingardi Roberto , Mazzucco Mauro

Recently ultrasound-guide radiofrequency thermal ablation has been proposed as an effective and safe procedure for treating patients who have low risk papillary thyroid microcarcinomas or are unfit for surgery. We present the case of a 56 years old patient with a small (10 mm) thyroid nodule diagnosed as TIR 4, suspect citology for papillary carcinoma after fine needle aspiration. The nodule was also studied with CEUS (Sonovue US contrast medium) which showed increased vascula...

ea0081ep978 | Thyroid | ECE2022

When sarcoidosis mimics cervical metastasis of thyroid cancer: a case report

Si Amer Sara , Benoumechiara Imene , Fedala Nora Soumaya

Introduction: Sarcoidosis is a systemic inflammatory disease characterized by noncaseating granulomas. Its pseudo-tumor manifestation in certain organs such as the thyroid can mimic thyroid carcinoma and lead to erroneous therapeutic decisions. We report a case of sarcoidosis with cervical adenopathy initially considered as a cervical metastasis of thyroid cancer.Observation: A 61-year-old woman, with a history of spontaneous subacute subdural hematoma o...

ea0081ep979 | Thyroid | ECE2022

Parathyroid carcinoma: about 3 cases and review of literature

Bouattay Rachida , Bergaoui Emna , Naouar Maroua , Ferjaoui Mehdi , Belhadjmiled Heyfa , Elkorbi Amel , Kolsi Naourez , Harrathi Kaled , Koubaa Jamel

Introduction: Parathyroid carcinoma is a very rare tumor. The reported incidence is between 0.5 to 5% of primary hyper parathyroidy in various series. This entity does not present any clinical or biological specificity compared to the parathyroid adenoma which exposes to diagnostic difficulties.Objective: The aim of our presentation is to study the clinical, therapeutic and evolutionary aspects of parathyroid carcinomas.Material an...

ea0081ep980 | Thyroid | ECE2022

Thyroidectomy in laryngeal squamous cell cacinoma

Mohamed Masmoudi , Zitouni Chaima , Thabet Wadii , Azer Chebil , Mahdi Hasnaoui , Khalifa Mighri

Introduction: Intraoperative management of thyroid gland in laryngeal cancer is controversial. In fact, there is no uniform consensus about the need for thyroid surgery in laryngeal cancer.Objective: Determine the incidence of thyroid gland invasion in patients undergoing surgery for laryngeal squamous cell carcinoma.Methods: A retrospective study including 62 cases of laryngeal squamous cell carcinoma who underwent a total larynge...

ea0081ep981 | Thyroid | ECE2022

Primary mucinous carcinoma of the thyroid gland: A rare tumour

Ayedi Sirine , Thabet Wadii , Mallouli Manel , Achour Imen , Hammami Bouthaina , Charfeddine Ilhem

Introduction: Primary mucinous carcinoma of the thyroid gland is extremely rare. To the best of our knowledge, only nine cases have been reported in the literature. Our aim is to report a case of primary mucinous carcinoma of the thyroid gland and to describe its diagnostic and prognostic features.Case Report: A 55-year-old man referred to our department for a 2-month history of an anterior neck mass associated with dysphagia. Physical exam showed a 4-cm...

ea0081ep982 | Thyroid | ECE2022

Association between vitamin D serum concentration and development of papillary thyroid cancer

Katalinic Darko , Aleric Ivan , Vcev Aleksandar , Solter Miljenko , Ranogajec Irena , Toetome Lars

Purpose: Papillary thyroid cancer (PTC) is the most common thyroid and endocrine malignancy worldwide. Vitamin D (calciferol or 25-hydroxyvitamin D) (25(OH)D) has been postulated as a key modulator in several cancer-related pathways, although its contribution to PTC still remain controversial. The aim of the study was to analyse the correlation between 25(OH)D serum levels and 25(OH)D insufficiency as well as the risk of development of PTC and its variants: classical type (CV-...

ea0081ep983 | Thyroid | ECE2022

A rare cause of metastasis to the thyroid gland: cervical carcinoma

Hocaoglu Erhan , Aydemir Ensar , Ates Coskun , Saridas Filiz Mercan , Cander Soner , Gul Ozen Oz , Ersoy Canan , Erturk Erdinc

Introduction: Metastasis to the thyroid gland is a rare clinical presentation. The most common sites of primary tumors that metastasize to the thyroid gland are kidney, lung, gastrointestinal system and breast. Primary gynaecological tumors are account for only 3% of secondary thyroid malignancies. Here, we present a case of thyroid metastasis from squamous cell carcinoma (SCC) of the cervix.Case: A 54-year-old female was consulted to our clinic with the...

ea0081ep984 | Thyroid | ECE2022

Thyroglobulin is a poor predictor of differentiated thyroid cancer in patients operated for thyroid nodular diseases

Rigbi Shoham , Baraf Lior , Joshua Ben-Zion , Yoel Uri , Fraenkel Merav

Background: Thyroglobulin, serves as a specific tumor marker following thyroidectomy in differentiated thyroid cancer (DTC) patients. However, its role as DTC predictor in patients with thyroid nodules (TN) is controversial.Aim: We aimed to assess the potential role of preoperative serum thyroglobulin concentration to predict DTC in patients who were operated for thyroid nodular disease.Methods: This retrospective study included pa...

ea0081ep985 | Thyroid | ECE2022

An unusual association between medullary thyroid carcinoma and testicular seminoma: Chemotherapy-induced complications, genetic predisposition or random relationship?

Septar AIlin , Smarandache Romeo , Niculescu Dan Alexandru , Goldstein Andrei , Braha Elena , Muresan Andrei , Caragheorgheopol Andra , Terzea Dana , Constantin Teodor , Buduluca Larisa , Musat Madalina

Medullary thyroid carcinoma (MTC) is a rare malignancy arising from parafollicular C cells of the thyroid gland, sometimes due to germline mutations in the RET protooncogene. Testicular cancer is the most common malignancy in men aged 15 - 40 years with survival rates improved by the introduction of cisplatin therapy in the late 1970s. Nonetheless, platinum-based chemotherapy was shown to increase the risk of a solid second cancer with substantially increased site-specific ris...

ea0081ep986 | Thyroid | ECE2022

Male gender is independent factor of poor prognosis in medullary thyroid cancer

Semenov Arseny , Chernikov Roman , Buzanakov Dmitry , Zolotukho Anna , Uspenskaya Anna , Gorskaya Nataliya , Ziborov Ivan , Chinchuk Igor , Novokshonov Konstantin , Karelina Yuliya , Elisey Fedorov , Makarin Viktor , Rebrova Dina , Shihmagomedov Shamil , Sleptsov Iliya

Background: The medullary thyroid carcinomas comprise 5-7% of all thyroid carcinomas. At the same time, they are responsible for up to 13% of all deaths of thyroid cancer.Incidence of sporadic medullary thyroid cancer in population 5-6 time higher in women, probably partially because women are likely to have thyroid nodules and undergo medical examination.Objective: The aim of the study is to determine how gender affects prognosis in patient...

ea0081ep987 | Thyroid | ECE2022

Thyroid Carcinoma in patients with Graves’ Disease: about 7 cases

Bouattay Rachida , Naouar Maroua , Bergaoui Emna , Belhadjmiled Heyfa , Ferjaoui Mehdi , Elkorbi Amel , Harrathi Kaled , Kolsi Naourez , Koubaa Jamel

Introduction: Graves’ disease (GD) is an autoimmune disorder characterized by diffuse hyperplasia and excessive production of thyroid hormone. The association between thyroid carcinoma and GD is controversial. Thyroid nodular lesions in patients with GD should raise a high suspicion of carcinoma. The aim of this study is to focus on the possibility of an association between hyperthyroidism and thyroid Carcinoma.Materials and Methods: This is a retro...

ea0081ep988 | Thyroid | ECE2022

Prevalence of differentiated thyroid carcinoma on hyperfunctioning or toxic thyroid nodules

Amuedo Dominguez Sandra , De Lara Rodriguez Irene , Lluch Ana R. Romero , Disotuar Suset Duen as , Hospital Juan L. Tirado , Navarro Elena

Background: Autonomic hyperfunctioning thyroid nodules account for approximately 5% to 10% of all thyroid nodules. Compared with non-toxic nodules, hot nodules are traditionally believed to have an exceptionally low malignancy rate, and this has led to recommendations not to perform fine-needle aspiration (FNA) on these lesions, regardless of their size. However, recent studies have questioned the presumed low risk of malignancy in hot nodules, suggesting that the incidence of...

ea0081ep989 | Thyroid | ECE2022

King of the CASTLE? Immunohistochemistry in diagnosing rare thyroid carcinomas: a case report

Stanciu Mihaela , Ristea Ruxandra Paula

Introduction: Carcinoma showing thymus-like differentiation (CASTLE) is a rare, low-grade thyroid carcinoma, with indolent clinical course and usually a favorable prognosis. The clinical and imagistic features are not specific for CASTLE but similar to other malignant lesions of the thyroid, making diagnosis difficult and reliant on immunohistochemical examination. The conclusive diagnosis requires pathological examination and positive cluster of differentiation 5 (CD5) immuno...

ea0081ep990 | Thyroid | ECE2022

Thyroid storm in a patient with severe leptospirosis managed with veno-venous extracorporeal membrane oxygenation

Christopher Ang Roy , Laura Marie Zuniga Yasmin

Background: Leptospirosis is an endemic zoonosis in the Philippines, with complications including jaundice from liver injury and acute kidney injury requiring renal replacement therapy. On the other hand, thyroid storm, most commonly in the setting of Graves’s disease, is a rare complication of hyperthyroidism. To date, thyroid storm has not been documented in patients with severe leptospirosis.Case Presentation: Herein, we present the case of a 52-...

ea0081ep991 | Thyroid | ECE2022

Thyroid abscess as a complication of post-COVID-19 subacute thyroiditis: a case report

Guissi Loubna , Amira Ikram , Rifai Kaoutar , Iraqi Hind , Gharbi Mohamed Elhassan

Introduction: Thyroid abscess is a rare pathology, with the incidence of less than 1% of all thyroid diseases. We describe a unique case of thyroid abscess complicating post-covid-19 thyroiditis, which is the first case reported in Morocco to our knowledge.Case presentation: A 39-year-old man who had recently recovered from a mild episode of COVID-19 infection, consulted for weight loss, palpitations and neck pain. Examination of the neck revealed enlarg...

ea0081ep992 | Thyroid | ECE2022

Ectopic lingual thyroid presenting as massive bleeding in a high-risk surgical patient treated with radioactive iodine

De Carlos Joaquin , Pineda Jose Javier , Anda Emma , Toni Marta , Ollero Maria Dolores , Munarriz Patricia , Irigaray Ana , Ernaga Ander , Esparza Nerea

Introduction: Lingual thyroid ectopia is a rare congenital abnormality affecting embryogenesis of the gland descent from foregut through pre-tracheal region in the neck. Most cases have an asymptomatic course but may occasionally produce local obstructive symptoms. Diagnostic methods are 99mTc, 131I or 123I radionuclide scan, computed tomography scan, magnetic resonance, and ultrasound. Surgery is the elective treatment for cases presenting com...

ea0081ep993 | Thyroid | ECE2022

Methimazole-induced cholestatic jaundice

Chayma Soltani , Belaid Rym , Naourez Abid , Lamine Hamzaoui , Raja Amri

Introduction: Methimazole is a widely prescribed antithyroid drug for the treatment of hyperthyroidism with a few adverse effects generally well-tolerated. However, methimazole-induced cholestatic jaundice (CJ) is a rare but serious adverse reaction. Herein we report a rare case of methimazole-induced CJ in a woman with hyperthyroidism.Case report: A 57-years-old women presented to our endocrinology department with a 2-week history of asthenia, insomnia,...

ea0081ep994 | Thyroid | ECE2022

Auto-immune polyglandular syndrome type IIIa: a case report

Belaid Rym , Chayma Soltani , Wafa Garbouj , Zeineb Alaya , Raja Amri

Introduction: Autoimmune polyglandular syndromes (APS) are rare polyendocrinopathies characterized by the failure of several endocrine glands as well as nonendocrine organs, caused by an immune-mediated destruction of endocrine tissues. The type IIIa APS is the association of thyroid autoimmune diseases, type 1 diabetes mellitus and other autoimmune conditions excluding Addison’s disease and hypoparathyroidism. Herein, we report the case of autoimmune hypothyroidism assoc...

ea0081ep995 | Thyroid | ECE2022

Coexisting grave’s disease and coeliac disease in an adolescent with down’s syndrome

Bouzid Anissa Ben , Belaid Rym , Abdelaziz Nada Ben , Abid Naourez , Amri Raja

Introduction: Trisomy 21 is the most common chromosomal disorder. It is associated with an increased risk of endocrinopathy particularly thyroid gland disorders. This is frequently a compensated hypothyroidism. Hyperthyroidism is rare. We report the case of an adolescent with Down’s syndrome and celiac disease who presented with subclinical hyperthyroidism.Case report: It was a 15-year-old female from a non-consanguineous marriage with a history of ...

ea0081ep996 | Thyroid | ECE2022

Primary thyroid lymphoma: case report

Sebile Dokmetaş Hatice , Karaipek Ku bra , Dokmetaş Meric , Kılıclı Fatih , Bayramgil Ayberk , Dorukhan Cavuşoğlu Guneş , Ozdenkaya Yaşar

Introduction: Primary thyroid lymphoma is a rare malignancy. In many series, it is reported that it is seen at a rate of 0.6-5% among thyroid cancers and approximately 2% among extranodal lymphomas. It is often seen as a painless mass in the neck. Almost all of them have underlying Hashimoto’s thyroiditis. In many instances, thyroid lymphoma was recognized after thyroid surgery for suspected carcinoma. The most common thyroid lymphomas are B-cell and Hodgkin lymphomas. Th...

ea0081ep997 | Thyroid | ECE2022

Influence of the mother’s history during pregnancy on the development of hyperthyroidism in children living in conditions of iodine deficiency

Muratova Shakhlo , Alimov Anvar , Azimova Shakhnoza

Our goal was to determine the anamnestic characteristics of mothers during pregnancy in children with hyperthyroidism living in conditions of iodine deficiency, which possibly contribute to the development of hyperthyroidism in patients of the pediatric group.Materials and methods of research: the analysis of the anamnesis of mothers during pregnancy of 146 children and adolescents with hyperthyroidism. The control group consisted of 97 relatively health...

ea0081ep998 | Thyroid | ECE2022

Thyroid disease in patients with type 1 diabetes

De Carlos Joaquin , Basterra Francisco Javier , Terreros Amaya Sainz De Los , Garcia Javier , Garcia Marta , Iriarte Ana , Marti Miguel , Jose Goni Maria

Introduction: An increased risk of thyroid disease (TD) has been described in patients with type 1 diabetes (DM1) with respect to the general population. The objective is to establish the incidence and characterize the differences in patients who develop TD in relation to the debut of DM1 (previous, concurrent or a posteriori).Materials and methods: Retrospective study of 1126 patients followed up in Endocrinology consultations in Navarra. Three types of...

ea0081ep999 | Thyroid | ECE2022

Serum selenium status in UK Graves’ disease patients with and without orbitopathy

Maden Carla , Eng Pei Chia , Choa Dri , Agha-Jaffar Rochan , Cox Jeremy , Yee Michael , Robinson Stephen , Fayers Tessa

Introduction: Selenium supplementation is recommended for all patients with mild Graves’ orbitopathy (GO). The thyroid gland contains high levels of selenium, which has an anti-oxidant effect and a role in the metabolism of thyroid hormones. The study on which this recommendation is based was conducted in countries of a selenium-deficient region and did not measure subjects’ selenium concentrations. There is therefore no consensus on optimum dose, duration, or safety...

ea0081ep1000 | Thyroid | ECE2022

Assessment of thyroid function in healthy pregnant women living in iodine deficiency regions

Rybakova Anastasia , Platonova Nadezhda , Nikankina Larisa , Malysheva Natalia , Troshina Ekaterina

Background: During pregnancy, the physiology of the thyroid gland undergoes important changes. As a result, change levels of thyroid hormones. In the latest clinical guidelines, experts have recommended to perform population-based studies to determine reference intervals for thyroid hormones.Aim: To evaluate the reference intervals of free thyroxine in different trimesters of pregnancy in women living in regions with mild iodine deficiency.<p class="...

ea0081ep1001 | Thyroid | ECE2022

Impact of age on hypothalamic-pituitary-thyroid axis

Popovic Pejicic Snjezana , Pejicic Nina

Background/Aim: Impact of age on hypothalamic –pituitary –thyroid axis, interesting from theoretical and practical aspects, have been studied. Our aim was to find out: correlation between T3 (triiodothyronine) and T4 (thyroxine) hormone level and old age, so as of other, for thyroid function relevant parameters: TSH (thyroid stimulate hormone), TRH (thyreothropin releasing hormone) test, thyroid ultrasonography, thyroid gland scintigraphy with 131 J, ...

ea0081ep1002 | Thyroid | ECE2022

Hypothyroidism associated with treatment with immunotherapy: case series

Zhao Montero Benitez Maria , Gonzalez Lazaro Paloma , Mendez Cristina Montalban , Tirado Antonio Moreno , Torrecilla Pedro Jimenez , Zaballos Florentino Del Val , Meneses Amparo Lomas , Alfonso Francisco Javier Go mez , Iglesias Maria Lopez , Gomez Garcia Ines

Introduction: The development of immunotherapy has opened up a new approach in the management of different types of tumors that previously had not treatment, and its use is becoming increasingly widespread. Immunotherapy is based on blocking immune checkpoints involved in activating the immune response to malignant neoplasms. Since its introduction into clinical practice, several adverse effects related to the immune system have been reported. Among the endocrinological advers...

ea0081ep1003 | Thyroid | ECE2022

Hyperthyroidism and pregnancy: About 70 patients

Elkhomri Amal , Salma Bensbaa , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: During pregnancy, the thyroid balance of women is altered due to certain hormonal and metabolic changes. It can be all the classic causes of hyperthyroidism, very often in the first trimester it is transient gestational hyperthyroidism.Objective of the study: The objective of this study is to evaluate the prevalence of hyperthyroidism during pregnancy and the different methods of management.Materials and methods: Pros...

ea0081ep1004 | Thyroid | ECE2022

Thyrotoxic hepatitis during pregnancy: about 42 cases

Elkhomri Amal , Salma Bensbaa , Haraj Nassim Essabah , aziz Siham El , Chadli Asma

Introduction: Hyperthyroidism in pregnancy is a common condition representing two different conditions: transient hyperthyroidism of pregnancy and true hyperthyroidism. It is accompanied by liver enzyme disturbances without any other obvious cause.Objective of the study: To evaluate the prevalence of acute hepatitis associated with hyperthyroidism.Matherials and methods: Prospective study conducted at the endocrinology and diabetol...

ea0081ep1005 | Thyroid | ECE2022

Abstract Withdrawn...

ea0081ep1006 | Thyroid | ECE2022

Insulin resistance and insulin-like growth factor-1 in patients with nodular goiter

Miroshnichenko Oksana , Karachentsev Iurii , Mykytyuk Myroslava , Khyzhnyak Oksana , Dubovyk Victor , Gerasymenko Leonid , Sazonov Maxim

Introduction: Publications suggesting that thyroid nodules might be associated with insulin resistance (IR) and metabolic syndrome are quite interesting. The aim of the work is to analyze the association between anthropometric indicators IR and insulin-like growth factor-1 (IGF-1) in patients with nodular goiter. Methods Examined 73 patients with euthyroid single-node (n=34) and multinodular goiter (n=39), age (51.0&pm;10.6) years; determinin...

ea0081ep1007 | Thyroid | ECE2022

Quality of life and symptomatology in patients with hypothyroidism post-graves’ disease

Pereira Miguel , Neves Celestino , Goncalves Juliana , Neves Joao Se rgio , Carvalho Davide

Introduction: Quality of life (QoL) and its related physical and psychological symptomatology is an important factor when we treat Graves’ disease.Objective: To analyze the QoL and physical and psychological symptomatology of patients with hypothyroidism after definitive treatment of Graves’ disease.Methods: We evaluated 16 patients with hypothyroidism that previously had Graves’ disease. These patients were submitte...

ea0081ep1008 | Thyroid | ECE2022

Rhabdomyolysis revealing a profound hypothyroidism

Camara M'ballou , Ettalibi Fatiha , Rafi Sana , Mghari Ghizlane EL , Ansari Nawal EL

Introducing: Hypothyroidism is the most common endocrinopathy causing rhabdomyolysis. Muscle manifestations are common in hypothyroidism, but myopathy is most often limited to discrete clinical signs such as myalgias, stiffness or cramps accompanied by a simple elevation of muscle enzymes. On the other hand, rhabdomyolysis associated with hypothyroidism is a rare diagnosis to our knowledge. We report a case of severe rhabdomyolysis in the setting of profound Hashimoto’s h...

ea0081ep1009 | Thyroid | ECE2022

Subacute thyroiditis following asymptomatic COVID-19 case report

Ilie Iuliana , Musat Madalina , Oprea Luciana

Subacute thyroiditis (SAT) is a relatively uncommon and self-limited cause of thyrotoxicosis of viral or post-viral origin. During the COVID-19 pandemic a thyroid impact was also considered due to the potential of SARS-CoV-2 virus to cause multiorgan effects. Several SAT cases associated with SARS-CoV-2 infection or vaccination were recently reported in the literature. We present the case of a 52-year-old female who presented with neck pain, fever, asthenia, and malaise for ap...

ea0081ep1010 | Thyroid | ECE2022

Serum TSH level in hospitalized patients with moderate-to-severe COVID-19

Mikhailova Arina , Lagutina Daria I. , Golovatyuk Ksenia , Chernikova Alena , Bystrova Anna , Karonova Tatiana

Background: Recently, clinical evidence of thyroid dysfunction has been observed both in acute and post-COVID period. The aim of this study was to estimate the serum TSH level in hospitalized patients with moderate-to-severe COVID-19.Methods: It was a single-center study conducted by the Almazov National Medical Research Centre (Russian Federation). Patients hospitalized with detected SARS-CoV-2 infection by RT-PCR test and chest computed tomography (CT)...

ea0081ep1011 | Thyroid | ECE2022

Long-term thyroid function in women diagnosed with subclinical hypothyroidism in pregnancy

Revuelta Rocio , Castro Ana , Martinez Belen , Cruz Andrea , Picazo-Perea Maria-Piedad , Martin-Torres Esther , Lopez-Martos Aurora , Vicente Almudena

Introduction: Subclinical hypothyroidism (SCHT) in pregnancy has been associated with adverse obstetric and perinatal outcomes. However, few studies have investigated the evolution of postpartum thyroid function in women first diagnosed with SCHT in pregnancy (gestational SCHT).Objective: To determine the evolution of thyroid function (TF) and the clinical and biochemical factors related to the long-term persistence of hypothyroidism (HT) in women with g...

ea0081ep1012 | Thyroid | ECE2022

The interplay between TSH and geriatric syndromes: results from the Moscow centenarians study

Matchekhina Lubov , Eruslanova Ksenia , Dudinskaya Ekaterina , Tkacheva Olga

Aim of the study: to assess the interaction between TSH and the most common geriatric syndromes in the cohort of centenarians Materials and Methods: It was a longitudinal study, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and &Mcy;OCA scores. We analyzed the interactions between TSH, m...

ea0081ep1013 | Thyroid | ECE2022

A possible complication of hypothyroidism: ischemic colitis

Mauntana Shielah , Gajendran Mahesh

Background: Ischemic colitis (IC) is a disorder characterized by a decrease in blood flow of the large intestine. Many factors can contribute to decreased blood flow in the arteries supplying the large intestine, such as nonocclusive causes like hypertension and atherosclerosis and occlusive causes like embolism from myocardial infarction. With Ischemic colitis’s high mortality rate and its association with many cardiovascular diseases, it’s important to understand c...

ea0081ep1014 | Thyroid | ECE2022

Thyroiditis as immune related adverse event to pembrolizumab plus lenvatinib therapy: a case report

Echchad Lamya , Ihssane Abidi

Introduction: The development of molecular biology and cancer immunology has brought drastic changes in anticancer in recent years. Recently, tyrosine kinase inhibitors (TKI) and immune checkpoint inhibitors (ICPIs) have emerged as new classes of anticancer therapies. Although generally considered less toxic than cytotoxic chemotherapy, these new drugs can cause significant side effects including thyroid dysfunction. We report the case of thyroiditis induced by Pembrolizumab (...

ea0081ep1015 | Thyroid | ECE2022

What is the ideal approach for thyroidectomy in a given patient? Proposal of an algorithm

Bangaraiahgari Ramesh , Bhargav Panchangam Ramakanth , Bangaraiahgari Rajesh , U Udaya Kumar , Mayilvaganan Sabaretnam

Introduction: Thyroidectomy can performed by open or wide array of endoscopic techniques. Lack of uniform consensus on specific indications for each technique leads to confusion on ideal thyroidectomy technique. In this context, we analysed our experience with specific emphasis on deducing an algorithm on ideal technique for a given patient. Material and methods: This is a retrospective study conducted at a tertiary care endocrine surgery department in S...

ea0081ep1016 | Thyroid | ECE2022

Opportunistic thyroid function screening in older medical patients in Ireland

Yi Joyce Tan Lok , Brassill Mary Jane

Introduction: Thyroid dysfunction is one of the commonest endocrine disorders with hypothyroidism being the most common thyroid dysfunction in the elderly population[1]. An elderly patient with thyroid dysfunction can be asymptomatic, or present with non-specific symptoms, making biochemical testing of thyroid function useful and essential. We reviewed the screening rate and prevalence of thyroid dysfunction in older medical patient patients admitted to an Irish sec...

ea0081ep1017 | Thyroid | ECE2022

Prevalence of thyroid disease among women receiving antenatal care at a tertiary care centre in Sri Lanka

Weerasinghe Kaveen

Introduction: Sri Lanka is endemic for goiters and recent studies show a high prevalence of thyroid dysfucntion among the population. However, data on thyroid dysfuntion among the general population and pregnant women in Sri Lanka is limited. Thyroid dysfunction is associated with adverse pregnancy outcomes. Furthermore, pregnancy related physiological changes increase the risk of thyroid dysfucntion. However, women in Sri Lanka are not routinely screened during pregnancy for ...

ea0081ep1018 | Thyroid | ECE2022

Carbimazole-induced hepatocellular injury in patient with Graves’ disease - avoid rechallenging

Ibrahim Hassan , Comia Maria , Abubakar Mustapha , Ip Richard , Ojewuyi Taofeek

Grave’s disease is an auto-immune disorder which responds well to medication and up to half of the patients who take anti-thyroid drugs go into remission. We present a patient with Graves’ disease, who developed acute hepatitis associated with Carbimazole and, re-challenged with Carbimazole when she represented with in fast atrial fibrillation (AF) with relapse of hepatitis. A 75 year-old lady admitted with palpitation and chest tightness. She had a background of par...

ea0081ep1019 | Thyroid | ECE2022

The hobnail variant of papillary thyroid carcinoma: clinical/molecular characteristics of a large monocentric series and comparison with conventional histotypes

Censi Simona , Manso Jacopo , Paganin Francesco , Vianello Federica , Galuppini Francesca , Pennelli Gianmaria , Iacobone Maurizio , Bertazza Loris , Barollo Susi , Mian Caterina

Background: Hobnail variant of papillary thyroid carcinoma (HPTC) has been recently identified. Given the rarity of the variant its characteristics have been studied only in little series, limiting the quality of the data available for its better management. The aims of our retrospective study were 1) to define the clinical and molecular characteristics of a series of HPTC in a monocentric and relatively large series; 2) to define the clinical and molecular characteristics abl...

ea0081ep1020 | Thyroid | ECE2022

Male was not a prognostic risk factor in postoperative DTC patients treated with 131I treatment: a propensity score-matching study

Zheng Wei , Zhou Yaqian , Wang Shen , Wang Xuan , Tan Jian

Objective: Propensity score matching (PSM) was used to study whether male patients with differentiated thyroid cancer (DTC) were the risk factors for prognosis after 131I treatment.Methods: 1677 patients with DTC who underwent total thyroidectomy and received 131I treatment were divided into male group (n= 546) and female group (n= 1131). The PSM method was adopted to process all the data to reduce the influence of...

ea0081ep1021 | Thyroid | ECE2022

Clinical experience with tyrosine kinase inhibitors in radioiodine-refractory differentiated thyroid cancer

Fernandez Valero Andrea , Damas-Fuentes Miguel , Montoro Jose Ignacio Marti nez , Vega Maria Molina , Doblas Isabel Mancha , Garcia Aleman Jorge , Ochoa Arantzazu Sebastian , Manuel Trigo Perez Jose , Jose Tinahones Madueno Francisco

Introduction: Differentiated thyroid cancer (DTC) represent 85- 90 % of all thyroid cancer cases. Most of these have an excellent prognosis with standard treatment. However, between 7 and 23% will develop distant metastases and, of these, more than 65% will become radioactive iodine-refractory. In some of these patients who are considered to be radioiodine-refractory with rapidly progressive or symptomatic disease, or in patients who are not candidates for other therapies, the...

ea0081ep1022 | Thyroid | ECE2022

Patterns of biological behavior of anaplastic thyroid cancer - case reports

Nonchev Boyan , Argatska Antoaneta , Dimov Rosen , Chonov Veselin , Chobankova Elena

Introduction: Anaplastic carcinoma of the thyroid (ATC) is the rarest and most aggressive thyroid gland cancer accounting for less than 5 % of all thyroid gland neoplasms. There is inconclusive evidence that ATC represents a terminal dedifferentiation of preexisting well-differentiated thyroid carcinoma or it may originate as already aggressive nondifferentiated cancer without any prior thyroid neoplasm. Case description: Case 1: A 74-year-old woman with...

ea0081ep1023 | Thyroid | ECE2022

Management and prognosis of anaplastic thyroid cancer

Sellami Moncef , Thabet Wadii , Mnejja Malek , Hammami Bouthaina , Kallel Souha , Charfeddine Ilhem

Introduction: Anaplastic thyroid carcinoma (ATC) is rare. This highly aggressive malignant tumor accounts for 2 – 3 % of all thyroid gland neoplasms. ATC continues to be one of the deadliest diseases worldwide and carries a very poor prognosis. The aim of this study was to describe the treatment modalities of ATC and its prognostic features.Methods: A retrospective study of patients with ATC treated in our department between 2004 and 2021.<p cla...

ea0081ep1024 | Thyroid | ECE2022

TSHR promoter methylation level changes as a prognostic blood-based biomarker in follicular thyroid carcinoma

Kazokaite Mintaute , Zukauskaite Kristina , Klimaitė Raimonda , Kondrotienė Aistė , Daukšienė Dalia , Zilaitiene Birute , Sabaliauskaite Rasa , Dauksa Albertas

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer, accounting for about 80% of all cases of thyroid cancer. Generally, PTC is an indolent disease and shows a good prognosis in most patients. However, up to 30% of patients have local tumor renewal or systemic spread. It is crucial to identify patients with a high risk of disease progression. DNA methylation biomarkers may provide clinically valuable information and improve ...

ea0081ep1025 | Thyroid | ECE2022

Routine molecular testing of fine needle aspiration biopsies of thyroid nodules

Sykorova Vlasta , Moravcova Jitka , Vaclavikova Eliska , Pekova Barbora , Mastnikova Karolina , Vcelak Josef , Novak Zdenek , Pacesova Petra , Grimmichova Tereza , Jiskra Jan , Bendlova Bela

Objectives: Fine needle aspiration biopsy (FNAB) together with ultrasonography is a necessary tool for diagnosis and follow up of thyroid nodules. Molecular testing is increasingly used mainly for indeterminate categories of the Bethesda System for Reporting Thyroid Cytopathology revised in 2017. Our aim was to introduce a routine molecular analysis of the main genetic causes of thyroid cancer.Methods: Since 2017 we have analyzed 1171 samples of patients...

ea0081ep1026 | Thyroid | ECE2022

Detection of rare variants in BRAF gene in thyroid nodules

Bendlova Bela , Sykorova Vlasta , Pekova Barbora , Vaclavikova Eliska , Moravcova Jitka , Mastnikova Karolina , Vlček Petr , Katra Rami , Kodetova Daniela , Lastuvka Petr , Bavor Petr , Drozenova Jana , Chovanec Martin , Vcelak Josef

Objectives: Papillary thyroid carcinoma (PTC) is the most frequent malignant endocrine disease and the most common genetic cause of the PTC is the substitution c.1799T>A (p.V600E) in the BRAF gene (35-70% of PTC) that represents more than 95% of BRAF mutations. Other rare mutations in the BRAF gene include other substitutions (e.g. p.K601E), small deletions or insertions close to codon 600. The aim was to analyze a large cohort of thyroid nodules...

ea0081ep1027 | Thyroid | ECE2022

Is obesity linked to thyroid cancer?

Toma Iustin-Daniel , Trifănescu Raluca-Alexandra , Mohora Maria-Alexandra , Baciu Ionela Florina , Baculescu Nicoleta , Ana-Maria Căpăţină Cristina , Duşceac Roxana , Andreea Găloiu Simona , Niculescu Dan Alexandru , Romeo Smărăndache Marian , Ioachim Dumitru Lucian , Poiană Cătălina

Background: During the past decades, the prevalence of both obesity and differentiated thyroid carcinoma increased worldwide. The link between obesity and thyroid cancer is controversial. Some studies found a relationship between obesity and thyroid carcinoma (especially BRAFV600E mutated) and between type 2 diabetes mellitus and thyroid cancer, while other did not. Aim: To assess the relationship between papillary thyroid carcinoma and increa...

ea0081ep1028 | Thyroid | ECE2022

Sub acute thyroiditis following COVID infection or vaccine: case reports

Haddad Hemmat El , Meligui Amr El , Salam Randa , Din Hesham Maged El , Rabie Ahmed , Amin Samar , Youssry Mona , Tarek Noha

Introduction: The novel severe-acute-respiratory-syndrome-coronavirus-2 virus has led to the ongoing Coronavirus disease 2019 (COVID-19) disease pandemic. There are increasing reports of extra pulmonary clinical features of COVID-19, either as initial presentations or sequelae of disease ((gastrointestinal, hepatobiliary, pancreatic, cardiovascular, ocular, and neurologic) Autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome) can be seen as a post-vaccination p...

ea0081ep1029 | Thyroid | ECE2022

Hashimoto’s thyroiditis manifested with rhabdomyolysis and cardiac effusion following SARS-CoV-2 vaccination: A case report

Smaili Rachid , Imrane Randa Ait , Raaidi Ikram , Bourkia Myriem

Background: Autoimmune inflammatory syndrome induced by adjuvants (ASIA syndrome), include the different conditions linked following exposure to an adjuvant. Auto-immune thyroiditis following vaccination as an auto-immune/inflammatory syndrome is rarely reported. In the era of mass vaccination against SARSCov2, there is limited information about cases of auto-immune thyroid disease as an ASIA syndrome following SARS-CoV-2 vaccination.Case: A 19years old ...

ea0081ep1030 | Thyroid | ECE2022

Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report

Tomasovic Martina , Sinik Marija , Joksimovic Bojan , Lackovic Milena , Samardzic Vladimir , Vujovic Marina , Gluvic Zoran , Obradovic Milan , Zafirovic Sonja , Isenovic Esma R.

Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became ...

ea0081ep1031 | Thyroid | ECE2022

Frequency of thyroid ultrasound alterations in polycystic ovary syndrome

Essayeh Sawsen , Frikha Wassim , Gharbi Radhouan , Madhi Wiem , Jemel Manel , Kammoun Ines

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of childbearing age. This condition combines, according to the diagnostic criteria of the Rotterdam consensus 2003, clinical and/or biochemical signs of hyperandrogenism, oligo- and/or anovulation and polycystic ovaries detected by ultrasound. Thyroid diseases are also frequent in the general population. The aim of our study was to determine the prevalence of thyroid ultrasound alterations in...

ea0081ep1032 | Thyroid | ECE2022

Efficacy of ethanol injection in cystic thyroid nodules

Kumar Naween , Ranjan Rajeev , Singh Siddharth

Introduction: Thyroid cystic nodules (TCN) are generally due to degenerative changes within colloid nodules or adenomas. True thyroid cysts are uncommon. But the prevalence of malignancy among TCN is controversial since some authors consider it to be low risk while some others consider it to have the same risks as malignancy as the solid lesions of the thyroid. Percutaneous ethanol injection (PEI) is utilised for treating benign cystic thyroid nodules. It is a protected option...

ea0081ep1033 | Thyroid | ECE2022

Pregnant patient with a history of methimazole-induced agranulocytosis presenting with hyperthyroidism: a case report

Abduraup Abdusattar , Barrera Jerome

Background: Pregnancy has a profound impact on the thyroid gland and its function. Severe thyrotoxicosis can lead to many complications and endanger the mother or fetus. Antithyroid drug (ATD), at its lowest possible dose, should be given. However, one of the complications of treatment include agranulocytosis which is a rare but serious allergic event with a prevalence of 0.1 to 0.5 percent. Thus, alternative treatment should be prescribed because a cross-reaction between ATDs...

ea0081ep1034 | Thyroid | ECE2022

Place of scintigraphy in case of diagnostic doubt in Graves’ disease

N'Koua Severin , Oussama Jaddi , Rafi Sana , Mghari Ghizlane EL , Ansari Nawal EL

Graves’ disease is a rare and severe disease that most often affects older children and is predominantly female. The diagnosis is made in the presence of a clinical picture very suggestive of thyrotoxicosis, confirmed by biological and radiological tests. We present the case of an 11-year-old female patient who presented with a moderate presented of basedow with an ultrasound appearance of thyroiditis for which scintigraphy was helpful in the diagnosis. Female patient, 11...

ea0081ep1035 | Thyroid | ECE2022

The effect of l-thyroxine replacement on blood pressure and heart rate in children with hypothyroidism: correlation with free thyroxine and thyrotropin levels

Elawwa Ahmed , Soliman Ashraf , Faraj Marwa

Chronic administration of L thyroxine to children with hypothyroidism may affect cardiovascular dynamics.Aim of the study: We measured the BP and heart rate (HR) of 25 randomly selected children with hypothyroidism in relation to their serum free T4, and TSH levels and thyroxine dose mg/kg. Methods: 25 randomly selected children with a mean age 9.6 +/- 4.5 years with the diagnosis of congenital or acquired hypothyroidism. They were...

ea0081ep1036 | Thyroid | ECE2022

Diagnosis and management of anaplastic thyroid carcinoma: about 3 cases and review of literrature

Bouattay Rachida , Bergaoui Emna , Naouar Maroua , Ferjaoui Mehdi , Belhadjmiled Heyfa , Elkorbi Amel , Harrathi Kaled , Kolsi Naourez , Koubaa Jamel

Introduction: Anaplasic thyroid carcinoma is an extremely aggressive undifferentiated tumor of follicular cell origin. It is uncommon and comprising approximately 1% of all thyroid cancers.Purpose of the presentation: The objective of this work is to determine the clinical, histological and therapeutic aspects of anaplasic thyroid carcinoma.Methods: This is a retrospective study about 4 patients treated for an anaplasic thyroid car...

ea0081ep1037 | Thyroid | ECE2022

Hürthle cell tumors of the thyroid gland: diagnostic and therapeutic features

Mohamed Masmoudi , Zitouni Chaima , Thabet Wadii , Ezer Chebil , Mahdi Hasnaoui , Khalifa Mighri

Introduction: Oncocytic tumors can occur in the thyroid gland and other endocrine tissues, including the parathyroid, pituitary gland, adrenal cortex, pancreas, gut, and lung. Thyroid oncocytic tumors are rare: 3-10% of thyroid epithelial tumors. They are characterized by the presence of oncocytic cells called “Hürthle” cells.Objective: Describe the clinical, pathological and therapeutic features of oncocytic tumors of the thyroid gland.</...

ea0081ep1038 | Thyroid | ECE2022

Type 1 diabetes mellitus and autoimmune thyroid disorders

Akid Faten Haj Kacem , Salah Raida Ben , Soomauroo Siddiqa , Missaoui AbdelMouhaymen , Chouaib Sarra , Marzouk Sameh , Charfi Nadia , Bahloul Zouheir , Abid Mohamed

Introduction: Type 1 diabetes mellitus (T1DM) is the result of the autoimmune destruction of beta-cells of the endocrine pancreas, leading to absolute insulin deficiency. The process of this autoimmune destruction occurs in genetically susceptible individuals with positive relevant autoantibodies. T1DM may be associated with other autoimmune diseases (AD) such as autoimmune thyroid disorders (AITD). Patients and methods: It is a descriptive retrospective...

ea0081ep1039 | Thyroid | ECE2022

Predictive tactors of malignancy in thyroid nodules: value of ultrasonography

Mohamed Masmoudi , Zitouni Chaima , Thabet Wadii , Azer Chebil , Mahdi Hasnaoui , Khalifa Mighri

Introduction: Ultrasound has become an indispensable diagnostic modality in the evaluation of the risk of malignancy of a thyroid nodule. Objective: Identify the predictive factors of malignancy in thyroid nodules on ultrasound.Methods: This is a retrospective study including 333 patients diagnosed with thyroid nodules and operated between 2010 and 2020. A significance threshold of 0.05 was adopted for the statistical analysis....

ea0081ep1040 | Thyroid | ECE2022

Risk factors for central neck lymph node metastasis in patients with macro and micropapillary thyroid carcinoma

Boutzios Georgios , Chatzi Sofia , Mina Areti , Koukoulioti Eleni , Giovannopoulos Ilias , Tsourouflis Gerasimos

Introduction: The prevalence of lymph node metastasis from micropapillary thyroid carcinoma (mPTC) in different studies is up to 33%. Preoperative diagnosis of central lymph node (CLN) metastasis is essential for the surgical management of those patients. Prophylactic CLN dissection for patients with mPTC is controversial. Our study aimed to assess the prevalence and the risk factors of LMN metastasis in patients mPTC Methods: We retrospectively study th...

ea0081ep1041 | Thyroid | ECE2022

Papillary thyroid cancer and its variants - genomic evidence and clinical significance

Katalinic Darko , Aleric Ivan , Vcev Aleksandar , Solter Miljenko , Ranogajec Irena , Toetome Lars

Purpose: Papillary thyroid cancer (PTC) accounts for approximately 80% of all thyroid cancers and is defined by its unique cytologic and histologic features. Mutations of the RET and BRAF/V600 genes are found in nearly 70% of PTC cases. They are able to trigger the activation of mitogen-activated protein kinase pathways and to promote neoplastic cell proliferation. Genetic events may further lead to numerous different cell variants of PTC which may be identified via t...

ea0081ep1042 | Thyroid | ECE2022

Graves’ disease associated with thyroid papillary carcinoma

Masmoudi Mohamed , Regaeig Marwa , Thabet Wadii , Chebil Azer , Hasnaoui Mehdi , Mighri Khalifa

Introduction: Thyroid carcinoma in Graves’ disease is rare (1 to 2%). Papillary carcinoma is the most common histologic type. It is usually discovered incidentally after histologic exam. Our aim is to report a case of Graves’ disease associated with thyroid papillary carcinoma and to describe its therapeutic and prognostic features.Case report: A 51-year-old woman treated with anti-thyroid drugs and β blockers for Graves’ disease. Cer...

ea0081ep1043 | Thyroid | ECE2022

Lymph node metastasis in adults and young adults with thyroid carcinoma: an algerian observation

Kaouache Nadjib , Zouraghen Bilal , Samira Merabet , Soumaya Grari , Sami Menacer , Ryma Boulefkhad , Chahinez Habi , Nassim Azzouz , Kassem Lezzar Al , Nouri Nassim

Introduction: Thyroid cancer (TC) in adolescents and adults (AYA) is defined as thyroid cancer diagnosed among those aged between 15-39 years. It is the fifth most common cancer in AYAs, and its incidence is increasing. Compared with older adult patients, the AYA with TC has a higher prevalence of node metastasis which represents a risk factor for recurrence.Aim: To describe the characteristics of thyroid carcinoma with confirmed nodal metastases at the ...

ea0081ep1044 | Thyroid | ECE2022

Dyshormonogenic goiter: about three cases

Ben Njima Marwa , Malika El Omri , haouas jihen , Abir Meherzi , Monia Ghammmam , Bellakhdhar Mouna , abdessayed nihed , Wassim Kermani , Mohamed Abdelkefi

Introduction: Dyshormonogenetic goiter (DG) is considered as a form of thyroid hyperplasia due to enzymatic defects in hormone synthesis. The architectural polymorphism and cellular atypia may mimic thyroid neoplasms and cause difficulties in differential diagnosis.Results: We report 3 cases of DG occurring in one females and two males who were aged 20, 9, and 7 years old, respictively. All patients presented with clinically evidence of goiter. Hypothyro...

ea0081ep1045 | Thyroid | ECE2022

Metachronous renal cell carcinoma metastasis to the thyroid

Cretu Cristina , Cristea Cristina , Barbacariu Ioana- Cristina , Dragoman Paula , Livenschi Lucia Flavia , Florescu Diana Nicoleta , Danila Radu , Ciobanu Delia , Preda Cristina

Introduction: Metastatic disease into the thyroid is a rare event, despite the gland’s rich vascular supply. Renal cell carcinoma (RCC) is an unusual neoplasm that not only has the potential to recur after a latent disease-free interval, but also has the potential to metastasize to rare sites like the thyroid. However, of the clinically significant secondary neoplasms of the thyroid, metastatic RCC is the culprit in most cases. Case report: We prese...

ea0081ep1046 | Thyroid | ECE2022

Occult papillary thyroid carcinoma with lymphatic metastasis as first presentation of the disease - A report of two cases

Haxhiraj Adela , Cerma Adishah , Hoxha Violeta , Ylli Dorina , Ylli Agron

Introduction: Occult papillary carcinomas are small thyroid carcinomas (<1 cm) diagnosed after an initial manifestation of lymph nodes or distant metastasis. We report two cases of patients with this pattern of clinical presentation.Case description: The first case is a 21-year-old woman, with a one-year history of a growing cervical cyst. Fine needle aspiration of the cyst showed metastasis from papillary thyroid cancer. She had no previous history ...

ea0081ep1047 | Thyroid | ECE2022

Thyroid incidental uptake at 18F-FDG PET/CT, an alert to malignancy - a case report

Manique Ines , Cortez Lui sa , Silva-Nunes Jose

Introduction: Thyroid incidentaloma in 18F-FDG PET-CT is relatively common and the most focal uptake are benign. However, the risk of malignancy of thyroid lesions with focal uptake on 18F-FDG PET-CT is 34.8%. Metastasis to the thyroid is uncommon (less than 0.2% of thyroid fine needle aspiration – FNA - puncture findings), with renal neoplasms being the most frequently associated (48.1%) and, more rarely, those from the breast (7.8%).Case report: A...

ea0081ep1048 | Thyroid | ECE2022

Papillary thyroid cancer with larger-volume lymph node metastases: evaluation of response to surgical treatment for decision making on indication of radioiodine

Tala Hernan , Slater Jeannie , Figueroa Jose Ignacio , Brigando Eduardo , Razmilic Josefina

Introduction: PTC patients with lymph node (LN) metastases of greater volume (in>5 LN and/or with larger metastases >5mm, hereinafter N1>5) usually receive radioiodine (RAI). Some guidelines suggest carrying out an evaluation of the response to surgical treatment (RST), recommending lower RAI dose (activity) in patients with good RST.Objectives: a)To evaluate the RST in patients with PTC and N1>5 b)To evaluate the disease-free-survival (D...

ea0081ep1049 | Thyroid | ECE2022

Worsening dysphagia and dysphonia: a case report

Rausa Donatella , Briganti Silvia Irina , Rossini Giovanni , Monte Lavinia , Napoli Nicola , Manfrini Silvia

Premise: multinodular goiter and compressive symptoms in the neck could not be necessarily associated.Case-report: A 82-year-old woman diagnosed follicular lymphoma in 2017 reached to the Emergency Department in Agoust 2021 because of a progressive and worsening dysphagia and dysphonia, begun six weeks before. The patient complained a weight loss of about 8 kg due to the inability in feeding. Her medical history was relevant for thyroid goiter, known sin...

ea0081ep1050 | Thyroid | ECE2022

Metastatic papillary thyroid carcinoma - a multidisciplinary approach

Manole Tiberiu , Baciu Ionela Florina , Dumitrascu Anda , Goldstein Liviu , Poiana Catalina

Introduction: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. It represents over 80% of all follicular derived well-differentiated thyroid cancers. Despite the fact that the majority of PTCs are well differentiated and have a low rate of local invasion, recurrences, or metastases, there are complex cases which require a multidisciplinary team for a favourable result.Methods: Clinical examination, blood tests, scintigraphy, CT s...

ea0081ep1051 | Thyroid | ECE2022

Rare association of two primary carcinomas: papillary thyroid carcinoma and pulmonary adenocarcinoma (about a case)

Raki Nezha , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: the coexistence of pulmonary adenocarcinoma and papillary thyroid carcinoma is a rare event. We report the case of a patient followed in consultation with thyroid carcinoma who was diagnosed with pulmonary adenocarcinoma.Observation: This is a 67-year-old patient, who had a total thyroidectomy for a multiheteronodular goitre with dissection of a pretracheal lymph node. Histopathological examination revealed a multifocal grade 1 thyroid papi...

ea0081ep1052 | Thyroid | ECE2022

Rare presentation of medullary thyroid carcinoma

Kishore Doulatram Gamgaram Viyey , Abuin Fernandez Jose , Cantero Araceli Pineda , Valdes Sergio , Jose Sanchez Torralvo Francisco

Introduction: Medullary thyroid cancer is a rare neoplasm, accounting for approximately 4% of all cases of thyroid cancer. Exceptionally, it can be associated with the hormonal production of ACTH or CRH, causing ectopic Cushing’s syndrome.Clinical Case: We present the case of a 43-year-old man who, as a history of interest, presented a T6-T8 vertebral body fracture 2 years ago and a right hip fracture 1 year ago. Bone densitometry is compatible with...

ea0081ep1053 | Thyroid | ECE2022

Differentiated thyroid cancer in children and adolescents: about 6 cases

Bouattay Rachida , Naouar Maroua , Bergaoui Emna , Belhadjmiled Heyfa , Ferjaoui Mehdi , Elkorbi Amel , Harrathi Kaled , Kolsi Naourez , Koubaa Jamel

Introduction: Thyroid cancer is rare in the pediatric population, but thyroid carcinomas occurring in children carry a unique set of clinical, pathologic, and molecular characteristics. In comparison to adults, children more often present with aggressive, advanced stage disease. The aim of the study is to determinate the clinical, histological and therapeutic aspects of differentiated thyroid cancer in children and adolescents.Materials and Methods: This...

ea0081ep1054 | Thyroid | ECE2022

Differentiated thyroid cancer with tuberculous cervical lymphadenopathymimicking metastasis: a report of 2 cases

Bouattay Rachida , Naouar Maroua , Bergaoui Emna , Belhadjmiled Heyfa , Ferjaoui Mehdi , Elkorbi Amel , Harrathi Kaled , Kolsi Naourez , Koubaa Jamel

Introduction: Papillary and follicular thyroid carcinoma are the most frequent endocrine malignancy. Lymphatic metastases at the time of diagnosis are common in differentiated thyroid cancer (DTC). In these patients, most authors recommend a thyroidectomy with neck dissection. However, neck dissection can lead to numerous post-operative complications. Thus, careful pre-operative evaluation of cervical lymph node metastasis may be crucial, so that patients do not undergo unnece...

ea0081ep1055 | Thyroid | ECE2022

Cushing’s disease and multiple endocrine neoplasia with medullary thyroid carcinoma and bilateral pheochromocytoma: about a case

Elkhomri Amal , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: Multiple endocrine neoplasia (MEN) are inherited conditions of autosomal dominant transmission characterized by the occurrence of various associated endocrine lesions. We report an observation of a patient with a rare association of medullary thyroid carcinoma and bilateral pheochromocytoma with cushing’s disease.Observation: The patient was H.B, 18 years old, followed for a medullary thyroid carcinoma (MTC) since 2018 discovered at th...

ea0081ep1056 | Thyroid | ECE2022

Thyroid oncocytic tumor: about 23 cases

Bouattay Rachida , Naouar Maroua , Bergaoui Emna , Belhadjmiled Heyfa , Ferjaoui Mehdi , Elkorbi Amel , Harrathi Kaled , Kolsi Naourez , Koubaa Jamel

Introduction: Oncocytic tumors (OT) are rare, representing 3 to 10% of epithelial tumors of the thyroid. It is important to individualize these tumors given the relatively high frequency of carcinomas and the aggressiveness of oncocytic carcinoma. The aim of this study is to determinate the clinical, histological and therapeutic aspects of thyroid oncocytic tumor.Materials and Methods: This is a retrospective study about 23 cases of oncocytic thyroid tum...

ea0081ep1057 | Thyroid | ECE2022

Correlation between body mass index and clinico-pathological features of papillary thyroid carcinoma

Khouchaf Hajar , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: Epidemiological studies have reported that being overweight and being obese are associated with increased incidences of numerous cancers, including thyroid cancer. In addition to cancer risk, obesity has also been demonstrated to be associated with more aggressive pathological characteristics of the tumor and worse prognosis in patients with several cancers.Purpose of study: Demonstrate the relationships between BMI and the clinico-patholog...

ea0081ep1058 | Thyroid | ECE2022

Adenocarcinoma of the colon and papillary thyroid carcinoma: An exceptional association

Khouchaf Hajar , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: The association of thyroid and colon cancer is rare, it can be observed in the context of Gardner’s syndrome and Cowden’s syndrome with a prevalence of 0.6%. We report a case of metachronous association of a differentiated thyroid cancer with a colon cancer.Observation: 45-year-old patient, followed for well-differentiated colonic adenocarcinoma without metastasis, having received eight courses of chemotherapy. One year later, the...

ea0081ep1059 | Thyroid | ECE2022

Association between breast cancer and thyroid cancer : About 55 cases

Khouchaf Hajar , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Background: Several studies have demonstrated the relationship between breast cancer and thyroid cancer by the presence of common genetic determinants. The aim of the study was to define the breast cancer prevalence among patients followed for thyroid carcinoma and to determine factors favoring this association.Matherials and methods: A Cross-sectional study was conducted in the Ibn Rochd University Hospital Endocrinology and Diabetology department of Ca...

ea0081ep1060 | Thyroid | ECE2022

Sorafenib for metastatic thyroid carcinoma

Cuconu Diana , Iulia Chiriac , Badiu Corin

Differentiated thyroid cancers include papillary, follicular carcinomas and are usually associated with a good prognosis. Up to 10% of patients develop metastatic lessions and radioiodine resistance. Tirosine kinase inhibitors (TKI) represent a strong therapeutic option for patients with advanced metastatic disease and radioiodine resistance. Sorafenib is the only TKI approved for the treatment of locally advanced or metastatic differentiated radioiodine resistant thyroid carc...

ea0081ep1061 | Thyroid | ECE2022

Horner syndrome as the first manifestation of medullary thyroid cancer

Dumea Bianca , Martin Carmen Sorina , Parfeni Ovidiu , Mustata Theodor , Predescu Florina Andrada , Simona Fica

Introduction: Medullary thyroid cancer is a rare neuroendocrine tumor arising from the parafollicular C cells of the thyroid gland. Calcitonin production is a characteristic feature of medullary thyroid cancer and preoperative high levels indicate an increased risk of local and distant metastatic disease. Although rare, Horner syndrome could be caused by metastatic medullary thyroid cancer. Horner syndrome usually presents with ptosis, miosis and facial anhidrosis and most of ...

ea0081ep1062 | Thyroid | ECE2022

Breakfast with liquid levothyroxine (Levotirsol®): a single-center experience

D'Andrea Settimio , Berardicurti Antonella , Santarelli Livia , Vena Walter

Introduction: Levothyroxine (LT4) tablets are the most used treatment for hypothyroidism worldwide. LT4 tablets should be taken in the morning and have a fasting state. Some patients could be unable to adhere to this recommendation resulting in poor therapy compliance and thyrotropin (TSH) concentration above the upper normal limits. A previous double-blind placebo-controlled trial showed that LT4 liquid could be ingested during breakfast without a significant difference in TS...

ea0081ep1063 | Thyroid | ECE2022

Therapeutic plasma exchange in amiodarone induced thyrotoxicosis: a case report

Clausi Cristina , Manso Jacopo , Graziani Andrea , Censi Simona , Carducci Sofia , Zhu Yi Hang , Piva Ilaria , Mian Caterina

A 52-year man came to Emergency Department with Atrial Fibrillation with rapid ventricular response due to amiodarone induced thyrotoxicosis (AIT). The patient was found tachi-arrhythmic (153 beats per minute), tachypnoic (27 breaths per minute) and with intense hyperidrosis. His first blood test documented thyroid stimulating hormone (TSH) <0.01 mUI/l, free triiodothyronine (fT3) 20.0 pmol/l and free thyroxine (fT4) over 100 pmol/l. Thyroid ultrasonography revealed an enl...

ea0081ep1064 | Thyroid | ECE2022

Congenital hypothyroidism due to hormone synthesis disorder: the value of early diagnosis

Farah Kamel , Abdouly Mohamedou , Azriouil Manal , Rifai Kaoutar , Iraqi Hind , Hassan El Gharbi Mohamed

Introduction: Primary congenital hypothyroidism is the most common neonatal endocrine disorder, traditionally subdivided into thyroid dysgenesis, referring to a range of abnormalities in thyroid development, and dyshormonogenesis. We report two cases of dyshormonogenesis in a brother and sister followed for congenital hypothyroidism by inactivating mutation of the TSH receptor, illustrating the good evolution in case of an adapted treatment.Clinical case...

ea0081ep1065 | Thyroid | ECE2022

Betrayed by the lab: a case of facticial thyrotoxicosis

Verissimo David , Ivo Catarina , Duarte Vito ria , Martins Ana Cla udia , Silva Joao , Lopes Luis , Passos Dolores , Castro J Ja come , Marcelino Mafalda

Introduction: Factitious thyrotoxicosis is caused by intentional and surreptitious ingestion of thyroid hormone and can be a challenge in the differential diagnosis with other pathologies.Case report: Female, 35 years old, referred to our department for suspected subacute thyroiditis after COVID-19. The patient had previous medical history of hysterectomy, bilateral oophorectomy, 2 galactophorectomies with right breast reconstruction, depressive syndrome...

ea0081ep1066 | Thyroid | ECE2022

A case of thromboembolic disease with mild hyperthyroidism

Soong Elaine , Rehman Shoib

Background: Hyperthyroidism is a thyroid hormone excess state which usually manifests with various cardiovascular complications such as sinus tachycardia, tachyarrhythmia and high output cardiac failure. Pulmonary embolism is not commonly associated with thyrotoxicosis but some studies have shown an increased propensity of thromboembolic disease with thyrotoxicosis. We rep...

ea0081ep1067 | Thyroid | ECE2022

A case report of hyperthyroidism which does not warrant antithyroid treatment

Hui Ooi Eng , Tong Chin Voon , Low Yen Nee

Introduction: The most common cause of hyperthyroidism in Malaysia is autoimmune cause like Grave disease, or toxic multinodular goitre. Thyroid hormone resistant syndrome is a rare genetic disease which usually presented with mild hyperthyroidism clinically and biochemically it had elevated free T4 and non suppressed TSH. Inexperienced doctor will commonly mistreat patient with antithyroid medication. This is because this genetic disease is extremely rare to encountered in pr...

ea0081ep1068 | Thyroid | ECE2022

Myo-Inositol Supplementation in autoimmune thyroiditis and subclinical hypothyroidism on the background of vitamin D deficiency.

Pasyechko Nadiya , Kulchinska Veronika

Background: In recent years, thyroid diseases have been occupying the top places in the structure of the endocrine pathology. There exists tight functional relationship between the thyroid and reproductive systems, which leads to a high probability of the development of combined disorders in one of these links of homeostasis. Vitamin D deficiency in the population remains a global problem. The purpose of the study is to investigate the effect of myoinositol on the thyroid stat...

ea0081ep1069 | Thyroid | ECE2022

The structure of thyroid dysfunction in children with type 1 diabetes mellitus

Nurgaliyeva Zhanar , Manasbayeva Araily , Amangeldi Zhanerke , Kholmirzayeva Nozima

Relevance: Type 1 diabetes mellitus (DM) is one of the most common endocrine disorders among chil-dren and accounts for 5-10% of all DM. According to scientists, in patients with type 1 diabetes, the risk of developing thyroid pathology is increased and with their combination, the course of both diseases worsens. There are different opinions among specialists regarding the clinical significance of latent thy-roid dysfunction. The study of the functional state of the thyroid gl...

ea0081ep1070 | Thyroid | ECE2022

Cardiac arrhythmias associated with subclinical primary hypothyroidism: about two cases

Ben Sassi Henda , Fadia Boubaker , Mkacher Wiem , Mechri Zohra El Mechri El , Mrabet Houcem , Wafa Alaya , Baha Zantour , Habib Sfar Mohamed

Introduction: Thyroid hormones play an important role in the normal functioning of cardiac and vascular physiology, therefore hypothyroidism results in profound cardiovascular effects. Arrhythmia in patients with hypothyroidism seems rare and not well recognized.Observation: Our first patient was a non-smoker 61-year-old woman, followed-up in the cardiology department for hypertension and dyslipidemia during the previous 5 years. She was treated with ACE...

ea0081ep1071 | Thyroid | ECE2022

Moyamoya disease and Graves’ disease in a Tunisian girl

Bel Hadj Sliman Chayma , Chaker Fatma , Grassa Anis , Khessairi Nadia , Oueslati Ibtissem , Chihaoui Melika

Introduction: There is an association between Moyamoya syndrome and Graves’ disease, described primarily in Asian populations. We report a case of Moyamoya vasculopthy with stroke and hypertension associated with graves’ disease in a 15-year-old Tunisian girl.Observation: A 15-year-old girl diagnosed with Moyamoya vasculopathy was referred to the endocrinology department for hyperthyroidism. The patient had a history of recurrent stroke and hyp...

ea0081ep1072 | Thyroid | ECE2022

Impact of Ramadan fasting on patients followed for Hypothyroidism.

Gueddari Amine , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: During Ramadan, Muslims change their eating and sleeping habits. All these changes can cause metabolic and hormonal variations. The main treatment for hypothyroidism is L-thyroxine. It is known that the absorption of L-thyroxine is optimal when taken on an empty stomach. Very few studies have been conducted to examine the best time to administer L-thyroxine during Ramadan.Objective of the study: To evaluate the impact of Ramadan fasting on ...

ea0081ep1073 | Thyroid | ECE2022

A retrospective study of the medical-surgical approach of a cohort of patients with Graves’ orbitopathy

Mendez Muros Mariola , Rave Garcia Reyes , Martin Hernandez Tomas , Manuel Garrido Hermosilla Antonio

Objective: To study the characteristics of a cohort of patients with Graves’ orbitopathy (GO) as a self-audit prior to the creation of a multidisciplinary team for the global approach of these patients.Material and Methods: Retrospective study of patients with GO treated at the Endocrinology and Ophthalmology Services of a tertiary referral hospital (Virgen Macarena University Hospital, Seville, Andalusia, Spain) between 2018 and 2021. The following...

ea0081ep1074 | Thyroid | ECE2022

Diagnosis of thyroid adenomas at the outpatient stage

Timofeeva Lubov , Yanovskaya Elena , Aleksandrov Yuriy

Methods of radiation diagnostics and fine needle aspiration biopsy (FNAB) are the methods of the first stage of diagnosis of thyroid nodules, which is confirmed by a large number of international recommendations. However, these methods do not always give the right answer for thyroid adenomas. The aim of the study was to study the effectiveness of a set of methods: ultrasound, sonoelastography, scintigraphy and FNAB in the diagnosis of thyroid adenomas. The study included 86 pa...

ea0081ep1075 | Thyroid | ECE2022

Bioelectrical Impedance Analysis (BIA) to measure alterations on hydroelectrolytic equilibrium of peripheral cells in COVID-19 patients with nonthyroidal illness syndrome (NTIS)

Sciacchitano Salvatore , Capalbo Carlo , Salvati Valentina , Alampi Daniela , Alessandri Elisa , Loffredo Chiara , Vitis Claudia De , Mancini Rita , Coluzzi Flaminia , Rocco Monica

In COVID-19 patients the occurrence of low T3 serum values is associated with disease severity and death, but hormonal substitutive replacement is still debated. Clinical trials reported so far failed to demonstrate clear beneficial effects of T3, T4 or both treatments. With the aim to analyze the peripheral effects of the acute deficiency of T3 in blood, we analyzed body fluid composition in 74 COVID-19 patients, admitted to our University Hospital during the last pandemic wa...

ea0081ep1076 | Thyroid | ECE2022

Autoimmune thyroiditis after 2 years covid pandemic: prevalence, clinical features, significance. Study on 450 patients in a medical center of Bucharest-Romania

Peretianu Dan , Stanciu Mihaela , Dana Oprea Cristina

Material-Method: We registered from February 26, 2020 until January 23, 2022 (almost 2 years) patients with chronic autoimmune thyroiditis Hashimoto. Usual parameters for this disease were investigated: age, sex, ATPO, FT4, TSH, ultrasound pattern, antibody evolution, immune associations, lost pregnancies, other clinical associations (alergies, breast cancer). Patients were divided into 2 groups: those who had covid-19 (C-19) vs. those who did not have viral disease (<u...

ea0081ep1077 | Thyroid | ECE2022

Clinical and paraclinical features of ectopic thyroid gland in adult patients.

Grassa Anis , Oueslati Ibtissem , Yezza Hajer , Yazidi Meriem , Chihaoui Melika

Introduction: Ectopic thyroid gland is a rare pathology due to an abnormality in the embryological development and/or migration of the gland. The aim of this study was to assess clinical and paraclinical characteristics of adult patients with ectopic thyroid gland.Methods: This was a retrospective study including adult patients with ectopic thyroid gland. Clinical, biological, hormonal, radiological and therapeutic data were collected.<p class="abste...

ea0081ep1078 | Thyroid | ECE2022

The relationship between type 2 diabetes mellitus with metabolic syndrome and clinical hypothyroidism

Rachdi Rim , Olfa Berriche , Lajili Olfa , Safi Eya , Amor Nadia Ben , Othman Rym Ben , Mizouri Ramla , Mahjoub Faten , Henda Jamoussi

Introduction: Metabolic syndrome is a multifactorial disease with multiple risk factors that arises from insulin resistance accompanying abnormal adipose deposition and function, increasing the risk of type 2 diabetes, one of the most common endocrine pathologies. Abundant evidence suggests an association between TSH levels, insulin resistance and some markers of the metabolic syndrome, without foreseeing the kind of this link. The aim of our study was to search if there was a...

ea0081ep1079 | Thyroid | ECE2022

Thyroiditis revealing a congenital anomaly: about an observation

Malika El Omri , Ben Njima Marwa , Mallat Amany , Bellakhdhar Mouna , Abir Meherzi , Haouas Jihen , Monia Ghammmam , Wassim Kermani , Mohamed Abdelkefi

Introduction: Remnants of the fourth branchial arch are extremely rare with less than 100 cases reported in the literature and account for 1–4% of all branchial anomalies. These anomalies typically present as recurrent neck infections and/or abscesses or acute suppurative thyroiditis. We report a case of cyst of the 4th cleft revealed by a thyroiditis treated in our department.Case report: A 6-year-old boy presented with recurrent neck swellings. Du...

ea0081ep1080 | Thyroid | ECE2022

Neutropenia in hyperthyroidism

Elias Ortega Cristina , Zunzunegui Nerea Egan a , Delgado Cristina Garcia , Calafell Maria Teresa Aramburu , Alvaro Jorge Rojo , Nebreda Inmaculada Venegas , Achucarro Ane Amilibia , Garay Ismene Bilbao , Arrieta Alfredo Yoldi

Introduction: Neutropenia can indicate infectious and hematological pathology but it can also be a sign of hyperthyroidism. For this reason, it has been suggested to perform a complete blood count before starting treatment with antithyroid drugs in case of new-onset hyperthyroidism. Antithyroid drugs can cause severe neutropenia, also called agranulocytosis, when the neutrophil count is less than 500/µl. Therefore, the use of these drugs should be reconsidered if it is le...

ea0081ep1081 | Thyroid | ECE2022

Thyrotoxic crisis presented as psychiatric decompensation

Martins Ferreira Mafalda , Araujo Catia , Lavrador Mariana , Guiomar Joana Reis , Oliveira Patri cia , Moreno Carolina , Paiva Isabel

Introduction: Thyrotoxic crisis is a rare endocrinological emergency with high mortality and it is more frequent in Graves’ disease.Clinical case: A 66-year-old women with schizophrenia was admitted to the Emergency Department due to altered state of consciousness, fatigue, constant moaning interspersed with unusual psychomotor agitation, heteroaggressiveness, diarrhea and anorexia. Lack of compliance with her psychiatric medication, new delusional ...

ea0081ep1082 | Thyroid | ECE2022

Lipid profile during block replace treatment in Graves disease

Stancu Ana-Maria , Dobrescu Ruxandra , Semonia Stanescu Laura , Badiu Corin

Introduction: Graves’ disease (GD) is an autoimmune disorder causing hyperthyroidism. Variations of functional profile as well as type and titer of thyroid specific antibodies makes the control often difficult. One treatment option is adding levothyroxine to anti-thyroid drugs (ATDs), so-called block-replace therapy (BRT).Aim: To study the BRT impact on lipid profile, thyroid function tests (TFTs) and TSH receptor antibodies (TRAb). <p class="ab...

ea0081ep1083 | Thyroid | ECE2022

Abstract Withdrawn...

ea0081ep1084 | Thyroid | ECE2022

Basedow disease and Susac syndrome: an exceptional association

Yahyaoui Arij Ezzouhour , Kefi Asma , Abdelghani Khaoula Ben , Sassi Syrine , Turki Sami , Euch Mounira El , Abderrahim Ezzeddine

Introduction: Susac syndrome is a rare endotheliopathy causing micro-ischemic damage to vessels in the brain, ears, and eyes. While the underlying aetiology of this disease remains unknown, it is widely believed that observed clinical manifestations result of an autoimmune endotheliopathy. Herein we report a case of Basedow’s disease associated to a scarce condition: Susac syndrome.Observation: Our patient is a 48-year-old woman, who was admitted fo...

ea0081ep1085 | Thyroid | ECE2022

The diffuse sclerosing form of papillary carcinoma of the thyroid

Abir Meherzi , Njima Marwa Ben , Bellakhdhar Mouna , Malika El Omri , Houas Jihene , Wassim Kermani , Mohamed Abdelkefi

Objective: Papillary thyroid carcinoma is the most common malignant tumor of the thyroid, the diffuse sclerosing variant is however very rare and represents between 0.7 and 6.7% of all papillary thyroid carcinomas. We propose through this poster to study its clinical, epidemiological, therapeutic and prognostic characteristics.Matherials and methods: We report two cases of diffuse papillary sclerosing carcinoma of the thyroid, collected at the ENT and CC...

ea0081ep1086 | Thyroid | ECE2022

Failure of rhTSH-stimulated FDG PET-CT scan to identify metastases of a papillary thyroid carcinoma

de Leon-Durango Ricardo , Hernandez-Lazaro Alba , Acosta-Calero Carmen , Kuzior Agnieszka , Arnas-Leon Claudia , Javier Martinez Martin Francisco

Introduction: Recurrences of differenciated thyroid carcinoma are occasionally hard to locate; rhTSH-stimulated FDG PET-CT may offer a higher sensitivity, particularly when thyroglobulin in high, but its utility has not been clearly established. Methods: Review of the patient’s clinical record Results: A 61 years old woman noticed a right anterior neck lump when she was 47; FNAC was suggestive of a solid papillary thyroid carc...

ea0081ep1087 | Thyroid | ECE2022

Autoimmune thyrotoxicosis Post SARS CoV-2 Vaccination

Maria Anthony Bernard Dorothy , Tong Chin Voon , Low Yen Nee

Introduction: Covid-19 vaccination have been introduced to reduce overall severity and mortality of COVID-19 infection. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a syndrome first described in 2011 that triggers autoimmune conditions after exposure to various adjuvants through various mechanisms. We report three cases of autoimmune thyrotoxicosis post mRNA type vaccine for COVID-19 possibly linked to adjuvants present in the vaccine....

ea0081ep1088 | Thyroid | ECE2022

Amiodarone-induced thyrotoxicosis refractory to medical therapy: A case report

Mhamdi Zineb , Mesmoudi Adil El , Moussaoui Souad El , Belmejdoub Ghislaine

Introduction: Amiodarone is an anti-arrhythmic drug rich in iodine compounds. One 200 mg tablet corresponds to about 25 times the daily requirement of iodine. One of the major complications of taking Amiodarone is the development of dysthyroidism which is observed in 15% to 20% of cases. Hyperthyroidism occurs in 1 and 13% of these patients.Case report: We report the case of an 34 year old female patient, followed for complete arrhythmia by atrial fibril...

ea0081ep1089 | Thyroid | ECE2022

The role of ACTB status for early non-invasive detection of papillary thyroid carcinoma

Klimaite Raimonda , Kazokaitė Mintautė , Kondrotienė Aistė , Dauksiene Dalia , Zilaitiene Birute , Dauksa Albertas

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer of all cases of thyroid cancer. Fine-needle biopsy by ultrasonography is still the main diagnostic method of PTC, but there is a technical limitation. That’s why, a minimally invasive diagnostic test that can accurately diagnose the onset of the disease is the subject of research.Our objective: We aimed to explore the concentration levels of ...

ea0081ep1090 | Thyroid | ECE2022

Thyroid carcinoma and anti-synthetase syndrome: A rare association!

Tekaya Asma , Kefi Asma , Abdelghani Khaoula Ben , Euch Mounira El , Sassi Cyrine , Turki Sami , Abderrahim Ezzedine

Background: Anti-synthetase syndrome (ASS) is an idiopathic inflammatory myopathy (IIM). Clinical features may include myositis, interstitial lung disease (ILD), non-erosive arthritis, Raynaud’s phenomenon, and mechanic’s hands with the presence of anti-synthetase antibodies. Although ASS-neoplasia association has been reported, it remains scarce and debated association. Herein, we report an original case of thyroid carcinoma in a patient followed for ASS.<p clas...

ea0081ep1091 | Thyroid | ECE2022

Diarrhea as the only symptoms in hyperthyroidism- case report

Tare Rajmonda

Introduction: Hyperthyroidism (overactive thyroid) is a condition where thyroid makes and releases high levels of thyroid hormone (thyroxine) in the blood. This condition can speed up our body metabolism. Hyperthyroidism causes an overactivity of the sympathetic system. It also this sympathetic hyperstimulation in the gut leads to increased motility causing diarrhea, malabsorbation and consequently weight loss. Objective: To describe a patient with hyper...

ea0081ep1092 | Thyroid | ECE2022

Case Report of Hypothyroidism as a Cause of Ataxia

Elgharroudi Farah , Zahra Ismail , Ansari Nawal EL , Mghari Ghizlane EL

We present a case of a 56-year-old male who reported to us with history of instability of gait since one year which was acute in onset and progressive, there was also history of hearing impairment and constipation since 3 years without improvement despite several symptomatic treatments. There was no history of weakness in any part of body, headache, vomiting, convulsions or alteration of sensorium. There was no history of trauma to the head, fever or drug intake. On examinatio...

ea0081ep1093 | Thyroid | ECE2022

Successful treatment of Graves’ disease with high dose iodine-131, without subsequent hypothyroidism: a case report

Brodovskaia Anna

Background: Radioiodine is an effective treatment for Graves’ hyperthyroidism. In most cases this therapy renders the patient completely hypothyroid. As a consequence they will require lifelong thyroid replacement therapy. Now it is controversial whether radioiodine should be given in a sufficient dose to induce hypothyroidism or a lower dose in an attempt to achieve a euthyroid state. Case Report: A 71-year-old woman with a 30 years history of Grav...

ea0081ep1094 | Thyroid | ECE2022

Papillary carcinoma of the thyroid and cervical teratoma: incidental association?

Alilouch Imane , Kamel Farah , Mhamdi Zineb , Rifai Kaoutar , Iraqi Hinde , Gharbi Mohamed Elhassan

Introduction: Teratomas are complex malformative tumors defined by the presence of tissues derived from the 3 embryonic layers. They can be mature or immature, depending on their degree of differentiation. They are most often found in the sacrococcygeal region and the gonads. Cervical location is exceptional (4%).Observation: We report the case of a 45-year-old patient who presented with a right cervical swelling that progressively increased in volume. T...

ea0081ep1095 | Thyroid | ECE2022

Retroplacental hematoma : a dreaded complication of hypothyroidism : An observational study

Douali Widad , Fatimaeezzahra Mennani , Sana Rafi , Ghizlane El Mghari Tabib , Nawal El Ansari

Introduction: Hypothyroidism is the most common endocrine dysfunction during pregnancy. In pregnancy, hypothyroidism is most often due to chronic autoimmune thyroiditis (Hashimoto’s disease) The consequences of hypothyroidism vary depending on the time of onset of hypothyroidism during pregnancy and the etiology retroplacental hematoma is a serious complication of hypothyroidism We report the case of a patient with in utero fetal death on retroplacental hematoma complicat...

ea0081ep1096 | Thyroid | ECE2022

Cholestatic Hepatitis in Graves’ Disease: A case report

Adel Meriem , Mekni Sabrine , Jridi Maysam , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Nacef Ibtissem Ben , Khiari Karima

Introduction: Thyrotoxicosis is an uncommon cause of cholestasis. It’s a diagnostic challenge considering the broad differential diagnosis. Herein we report a case of Grave’s disease revealed by severe cholestatic jaundice.Observation: A 46 old male with a history of Sickle cell disease complained of diarrhea and significant weight loss for eight months, followed the last month by palpitations, heat intolerance, anxiety, insomnia and progressiv...

ea0081ep1097 | Thyroid | ECE2022

A rare localization of lymph node metastasis from papillary thyroid carcinoma

Masmoudi Mohamed , Thabet Wadii , Regaeig Marwa , Chebil Ezer , Hasnaoui Mehdi , Mighri Khalifa

Introduction: Lymph node (LN) metastases of papillary thyroid carcinoma (PTC) usually happen in the paratracheal and internal jugular chain and are unusual in the parapharyngeal space (PPS). Our aim is to emphasize on the possibility of parapharyngeal metastatic LNs in PTC and to describe the diagnosis methods, treatment options, and impact on the prognosis.Case Report: A 62-year-old woman presented with a dysphagia lasting for 2 years. Examination revea...

ea0081ep1098 | Thyroid | ECE2022

Malignant non-Hodgkin lymphoma of the thyroid Gland: About 4 cases

Bouattay Rachida , Bergaoui Emna , Naouar Maroua , Ferjaoui Mehdi , Belhadjmiled Heyfa , Elkorbi Amel , Harrathi Kaled , Kolsi Naourez , Koubaa Jamel

Introduction: Cervico-facial non hodgkin lymphomas are rare conditions; they represent 5% of all malignant tumors of the head and neck. Their localizations are essentially lymph nodes but all the organs can be affected.Purpose of the presentation: The objective of this work is to determine the clinical, histological and therapeutic aspects of malignant non-Hodgkin lymphoma localized in the thyroid gland.Methods: This is a retrospec...

ea0081ep1099 | Thyroid | ECE2022

COVID-19 vaccine-associated subacute thyroiditis

Chia Eng Pei , Davidson Lien , Agha-Jaffar Rochan , Cox Jeremy , Yee Michael , Moriarty Maura , Robinson Stephen , Vakilgilani Tannaz , Bravis Vassiliki

Introduction: Subactue thyroiditis (SAT) is a self-limiting inflammatory condition caused by follicular destruction of the thyroid gland, commonly precipitated by viral upper respiratory tract infection 2 weeks preceding the onset of thyroid symptoms. However, SAT following COVID-19 vaccination is rare. Herein, we report two cases of subacute thyroiditis which presented after administration of COVID-19 vaccine. Case series: The first patient was a 42 yea...

ea0081ep1100 | Thyroid | ECE2022

Autoimmune thyroid disease and autoimmune hepatitis

Salah Raida Ben , Akid Faten Haj Kacem , Soomauroo Siddiqa , Chehaider Cyrine , Chouaib Sarra , Rekik Nabila , Frikha Faten , Abid Mohamed , Bahloul Zouheir

Introduction: Autoimmune hepatitis (AIH) is a generally progressive and chronic liver disease that can occur both in children and adults. Although the cause of AIH is unknown, aberrant auto-reactivity is thought to have a role in its pathogenesis. The diagnosis is based on clinical presentation, biological and histological findings. Like other autoimmune diseases (AD), AIH can be associated with one or more AD either organ-specific or non-organ specific AD. <p class="abste...

ea0081ep1101 | Thyroid | ECE2022

Thionamides induced hypoglycemia

Aviran Barak Nirit

A 22-year-old female Ashkenazy Jewish previously healthy complaint on weakness In glucometer, her sugar level was 50 mg% and she felt better after ingestion of a small amount of sugar. 3 weeks ago while traveling in Peru, she developed thyrotoxicosis and was started mercaptizol 30 mg a day and deralin. She didn’t drink iodine (iodinated preparations for water purification) while traveling and had no pain or fever. In physical examination there where no goiter or exophthal...

ea0081ep1102 | Thyroid | ECE2022

Differential diagnosis between overt and transient hyperthyroidism in triplet pregnancy

Abesadze Nino

Introduction: Thyroid health in pregnancy is highly important. Best way to evaluate thyroid in pregnancy, is thyroid function assessment via blood tests. But we always have to focus also on clinical manifestations, thyroid ultrasound and other factors, that may influence test results. As we know high HCG can suppress TSH and twin pregnancy may induce subclinical hyperthyroidism. There are many reports of twin pregnancies, but very few about triplet pregnancy. Therefore we deci...

ea0081ep1103 | Thyroid | ECE2022

Clinical profile and body composition of patients newly diagnosed with hypothyroidism

Lajili Olfa , Chadia Zouaoui , Najla Bchir , Abderrahim Yosra , Benchhida Annam , Ouertani Haroun

Introduction: Patients with hypothyroidism usually gain weight, and those with hyperthyroidism lose weight. Body weight changes related with thyroid dysfunction support the idea that thyroid hormones have an effect on body weight and body composition. The aim of our study was to describe the clinical profile and body composition of Tunisian patients who were newly diagnosed with hypothyroidism.Methods: This was a cross-sectional and descriptive study inc...

ea0081ep1104 | Thyroid | ECE2022

Graves’ disease: Particularities in the pediatric population

Ben Salah Dhoha , ARBI Kawthar El , Zargni Asma , Elleuch Mouna , Chehaider Cyrine , Fatma Mnif , Charfi Nadia , Mnif Mouna , Majdoub Nabila Rekik , Akid Faten Haj Kacem , Abid Mohamed

Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism in pediatric patients, up to 95% in some studies.Observation: We report the observation of a 6-year-old female who consulted for a behavioral disorder made of agitation and lack of concentration. She had a family history of autoimmune thyroid disease. On examination, an accelerated statural growth rate of +2DS was noted. She had a significant palpebral retraction without ...

ea0081ep1105 | Thyroid | ECE2022

Hashimoto’s thyroiditis associated with primary biliary cholangitis: a case report

Ouakrim Hind , Ndong Charlene Ludwine Bifoume , Rafi Sana , Mghari Ghizlane EL , Ansari Nawal EL

Introduction: The association of multi-organ autoimmune disorders is described. We report a case of Hashimoto’s thyroiditis (HT) and primary biliary cholangitis (PBC), both are a chronic autoimmune inflammation, with lymphocytic infiltration and destruction of thyroid cells for (HT) and progressive destruction of intrahepatic bile ducts leading to cirrhosis for (PBC)Case report: 54-year-old female patient, followed for (PBC) at cirrhosis stage admit...

ea0081ep1106 | Thyroid | ECE2022

Nephrotic lupus revealing a profound hypothyroidism

N'Koua Severin , Rafi Sana , Mghari Ghizlane EL , Ansari Nawal El

Systemic lupus erythematosus is a serious autoimmune disease characterised by the production of antinuclear antibodies directed particularly against native DNA. Its presence increases the susceptibility to develop other autoimmune diseases including autoimmune dysthyroidism. We present the case of a patient who presented with profound hypothyroidism as part of the work-up for lupus nephropathy. Female patient, 40 years old, reports physical asthenia for 2 months. On clinical e...

ea0081ep1107 | Thyroid | ECE2022

Diarrhea as the only symptoms in hyperthyroidism-case report

Tare Rajmonda

Introduction: Hyperthyroidism (overactive thyroid) is a condition where thyroid makes and releases high levels of thyroid hormone (thyroxine) in the blood. This condition can speed up our body metabolism. Hyperthyroidism causes an overactivity of the sympathetic system. It also this sympathetic hyperstimulation in the gut leads to increased motility causing diarrhea, malabsorbation and consequently weight loss. Objective: To describe a patient with hyper...

ea0081ep1108 | Thyroid | ECE2022

Autoimmune thyroiditis and anemic syndrome

Saidova Farida , Akhmedova Leyli , Aslanova Jale , Shahsuvarov Oruc , Muradov Nizami

The purpose was to identify the frequency of occurrence of various morphological types and different degrees of severity of anemia in patients with autoimmune thyroiditis (AIT).Material and methods: Were analyzed 97 case histories of patients operated for AIT in 2012. When assessing hematological parameters, two groups were identified: group 1 – patients with AIT with mild anemia (n= 72), age 45.7 &pm; 1.6, men - 5 (6.9%), ...

ea0081ep1109 | Thyroid | ECE2022

Subacute thyroiditis associated with COVID-19

Aleksandrov Yuriy , Semikov Vasiliy

COVID-19 is a serious problem of modern medicine. The disease has many manifestations, as it affects almost all organs and systems. One of the target organs of the endocrine system is the thyroid gland. The aim of the study was to identify the patterns of development and course of subacute thyroiditis in patients who underwent COVID-19. The study included 9 clinical cases. In all cases, these were women aged 32 to 54 years. All patients were sick with COVID-19 (4 of them were ...

ea0081ep1110 | Thyroid | ECE2022

A case of graves’ orbitopathy in a patient sero-negative for TSH receptor autoantibody

Besrour Chayma , Imen Rojbi , Sabrine Mekni , Adel Meriem , Nadia Mchirgui , Ibtissem Ben Nacef , Karima Khiari

Introduction: The orbit represents the second target after the thyroid gland in autoimmune dysthyroidism. In 80% of cases, endocrine orbitopathy occurs as a result of hyperthyroidism, especially Grave’s disease (GD). Males are rarely affected but the damage is more serious.Observation: We report the case of a 52-year-old patient, an active smoker (35 Pack-Year), transferred from the neurology department for treatment of bilateral malignant exophthal...

ea0081ep1111 | Thyroid | ECE2022

Graves’ disease refractory to a cumulative dose of 72 mci of iodine 131

Chaimae Kadiri , Hassan Lachkar

Introduction: Graves’ disease is the most common cause of hyperthyroidism. There are three main therapeutic weapons: synthetic antithyroid drugs, surgery and radioactive iodine. The latter represents an effective treatment without noticeable side effects. We report a case of Graves’ disease refractory to iratherapy.Observation: This is a 38-year-old patient, with no notable history, who consulted for Graves’ disease diagnosed with clinical...

ea0081ep1112 | Thyroid | ECE2022

Thyroid tuberculosis: a case report

Chaimae Kadiri , hassan lachkar

Introduction: Thyroid tuberculosis is a rare localization that can pose problems of differential diagnosis with thyroid nodules. Its rarity is explained by the good oxygenation of the thyroid parenchyma and the bacteriostatic role of thyroid hormones. The definitive diagnosis is based on the pathological examination of the surgical specimen or after cytopathology or bacteriological examination of the transparietal puncture in complicated cases of collection.<p class="abste...

ea0081ep1113 | Thyroid | ECE2022

Coexistence of two different thyroid malignancies: an exceptional phenomenon

Ferjaoui Mehdi , Bergaoui Emna , Naouar Maroua , Bouattay Rachida , Elkorbi Amel , Kolsi Naourez , Harrathi Kaled , Koubaa Jamel

Introduction: Simultaneous papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) of the same thyroid lobe is a very rare pathology. Purpose of the presentation: The objective of this work is to determine the clinical, histological and therapeutic aspects of an association of papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) on the same thyroid lobe.Methods: We report 2 cases of PTC and FTC ...

ea0081ep1114 | Thyroid | ECE2022

Differentiated thyroid carcinoma in Basedow disease : a series of five cases

Farah Kamel , Gorgi Khaoula , Rifai Kaoutar , Iraqi Hinde , Hassan El Gharbi Mohamed

Introduction: The occurrence of thyroid cancer in Basedow disease is rare. We report a series of five cases of patients with Basedow disease who were operated on and whose pathological examination showed an association with differentiated thyroid cancer.Clinical cases: We report a series of five patients with a mean age of 39 years. The diagnosis of Basedow disease was made on the basis of clinical, biological and scintigraphic evidence. Cervical ultraso...

ea0081ep1115 | Thyroid | ECE2022

Coexistence of chronic lymphocytic thyroiditis with papillary thyroid carcinoma: about 13 cases

Bouattay Rachida , Naouar Maroua , Bergaoui Emna , Belhadjmiled Heyfa , Ferjaoui Mehdi , Amel Elkorbi , Khaled Harrathi , Naourez Kolsi , Koubaa Jamel

Introduction: The association between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) has been investigated for several years from different perspectives. In spite of that, there were only few attempts to design a common frame of references to understand the complex mutual interactions between the various pathways of inflammatory response and of thyroid tumor induction and progression. The aim of this study is to investigate the clinical characteris...

ea0081ep1116 | Thyroid | ECE2022

Distant metastases from thyroid cancers: About 4 cases

Ben Njima Marwa , Malika El Omri , Bellakhdhar Mouna , Haouas Jihen , Monia Ghammmam , Abir Meherzi , Abdessayed Nihed , Wassim Kermani , Mohamed Abdelkefi

Introduction: Metastases of thyroid tumors are rare. Metastatic sites are in order of frequency : pulmonary, bone and brain. Facial bones metastases are exceptional. These metastases are more frequent in vesicular than papillary carcinoma histological. The aim of our work is to describe the clinical and radiological aspects as well as the therapeutic modalities.Observation 1 and 2: A 38-year-old woman and 13-year-old boy consulted for a chronic cough wit...

ea0081ep1117 | Thyroid | ECE2022

Managing thyroid storm in acute setting: a single centre experience case series

Elekwa Gloria , Elonu Akunna , Volmy Rebecca , Williams Alexanderia , Mlawa Gideon , Bell Janessa

Background: Thyrotoxicosis is one of the commonest endocrine disorders and its severe form can manifest as thyroid storm in acute setting leading to organ dysfunctions including heart failure. Cases: 1: A 58-year-old female with a significant past medical history of MI, paroxysmal AF/atrial flutter, and hyperthyroidism presented with a one-week history of palpitations, plethora, diaphoresis, heat intolerance, loose stools, and a TSH <0.01; Free T4-33...

ea0081ep1118 | Thyroid | ECE2022

Factitious thyrotoxicosis: A case report

Khouchaf Hajar , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: Although the most common cause of thyrotoxicosis is Graves’ disease, identification of other causes is important to establish appropriate management. The diagnosis of factitious thyrotoxicosis often presents a difficult challengebut should not be overlooked. We report a case of a patient with treated thyroid carcinoma who presented with factitious hyperthyroidism.Observation: 50-year-old patient, followed for papillary thyroid microcar...

ea0081ep1119 | Thyroid | ECE2022

Simultaneous occurrence of medullary and papillary thyroid carcinomas: a report of 2 cases

Ferjaoui Mehdi , Naouar Maroua , Bergaoui Emna , Bouattay Rachida , Amel Elkorbi , Khaled Harrathi , Naourez Kolsi , Koubaa Jamel

Introduction: Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are two different types of thyroid carcinoma with significant different clinical and histological findings. Synchronous occurrence of these two carcinomas is uncommon. The aim of the study is to determinate the clinical, histological and therapeutic aspects of the coexistence of medullary and papillary thyroid carcinomas.Materials and Methods: We report two rare cases o...

ea0081ep1120 | Thyroid | ECE2022

Postoperative hypoparathyroidism after total thyroidectomy: prevalence and risk factors

Ferjaoui Mehdi , Naouar Maroua , Bergaoui Emna , Bouattay Rachida , Amel Elkorbi , Khaled Harrathi , Naourez Kolsi , Koubaa Jamel

Introduction: Total thyroidectomy is the most common surgical procedure for the treatment of thyroid diseases. Postoperative hypoparathyroidism and the resulting hypocalcemia are frequent complications after total thyroidectomy. The aim of this study was to assess the rate of postoperative hypoparathyroidism after total thyroidectomy in order to identify potential risk factors. Methods: We designed a retrospective study including 387 patients with total ...

ea0081ep1121 | Thyroid | ECE2022

Metastatic medullary carcinoma of the thyroid

Khouchaf Hajar , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: Medullary thyroid carcinoma (MTC) is a rare and silent endocrine tumor representing 5-10% of thyroid cancers. It is the most aggressive form of thyroid carcinoma, usually diagnosed at advanced stages.Purpose of study: Study the phenotypic and genotypic profiles as well as the anatomical-histological characteristics related to the recurrence of the disease.Matherials and methods: Descriptive cross-sectional study inclu...

ea0081ep1122 | Thyroid | ECE2022

Papillary thyroid carcinoma revealed by hyperthyroidism

Najoua Messaoudi , Assarrar Imane , Bouichrat Nisrine , Karrou Marouan , Rouf Siham , Latrech Hanane

Introduction: Papillary thyroid carcinoma is the most common histological type of differentiated thyroid malignancy. This type of tumor is rarely associated with thyroid hormone hypersecretion. We report the case of a patient with papillary thyroid carcinoma revealed by hyperthyroidism. Case report: A 35 years old patient was admitted for the management of malignant hypercalcemia discovered incidentally on the biological workup performed preoperatively f...

ea0081ep1123 | Thyroid | ECE2022

Two types of thyroid cancer in one patient

Muzurovic Emir , Borozan Sanja , Vujosevic Snezana

A 65–year-old male was referred to endocrinologist due to significantly elevated calcitonin level of 3662 pg/ml. Previously, almost 3 decades before, the patient underwent right thyroid lobectomy for papillary carcinoma. Then, 9 years afterwards, he was reoperated and total thyroidectomy with neck exploration was performed. In pathohistological finding, metastatic papillary carcinoma was proved. Radioactive iodine ablation was used as a post surgical treatment. After comp...

ea0081ep1124 | Thyroid | ECE2022

Branchial cyst into the thyroid gland: an usual presentation

Ayedi Sirine , Medamin Chaabouni , Hammami Rim , Sellami Moncef , Najla Abid , Charfeddine Ilhem

Introduction: Fourth branchial cleft cyst are commonly reported as recurrent low-neck abscesses, acute suppurative thyroiditis, and neck masses. We report an accidental finding of a fourth branchial cleft as a suspected thyroid nodule. Case presentation: We present a case of a 47-year-old woman who consulted the Ear, Nose, and Throat department of our hospital with a 4-year history of thyroid nodule. The thyroid nodule was discovered incidentally on ultr...

ea0081ep1125 | Thyroid | ECE2022

Thyroid nodule: an exceptional mode of revelation of extrapulmonary Tuberculosis

Yahyaoui Arij Ezzouhour , Kefi Asma , Khaoula Ben Abdelghani , Mounira El Euch , Syrine Sassi , Sami Turki , Ezzeddine Abderrahim

Introduction: The incidence of extrapulmonary forms of tuberculosis has increased. Thyroid tuberculosis is an uncommon condition even in developing countries where tuberculosis is endemic. Herein we report an original case of a 62 year-old woman in whom tuberculosis was revealed by thyroid nodule. Observation: Our patient is a 62-year-old woman with a history of mild asthma for 7 years. She presented with a slight neck swelling and a loss of weight and a...

ea0081ep1126 | Thyroid | ECE2022

Multinodular goiters: management

Abir Meherzi , Njima Marwa Ben , Khalifa Mouna , Bellakhdhar Mouna , Malika El Omri , Houas Jihene , Wassim Kermani , Mohamed Abdelkefi

Background: analysis the epidemiologic and the clinical features of this entity, then to discuss the management Patients and methods: We report a retrospective study of 120 patients operated on for multi nodular goiter over a period of 5 years between January 2017 and December 2021.Results: In our study a female predominance was noted with a sex ratio F/H of 8/1. The average age of the patients was 44 years with extremes from 15 to...

ea0081ep1127 | Thyroid | ECE2022

Graves’ disease: surgical management

Abir Meherzi , Sghaier Habiba Ben , Bellakhdhar Mouna , Malika El Omri , Houas Jihene , Wassim Kermani , Mohamed Abdelkefi

The goal of this study is to examine the role of surgery in the treatment of Graves’ disease and to assess the surgical outcomes.Methods: We present the results of a retrospective analysis of 31 Graves’ disease cases operated on in the ENT and cervico-facial surgery departments of Farhat Hached Sousse Hospital during a six-year period [2015-2021]. Our group consisted of 05 males and 26 women. The average age ranged from 12 to 70 years. Between ...

ea0081ep1128 | Thyroid | ECE2022

Hypoparathyroidism Post-total thyroidectomy: pathophysiology and management

Abir Meherzi , Jemli Safa , Bellakhdhar Mouna , Malika El Omri , Houas Jihene , Wassim Kermani , Mohamed Abdelkefi

Thyroid surgery is a frequent procedure that has certain risks. After a complete thyroidectomy, hypocalcemia is the most prevalent consequence. It has a variety of causes, with hypoparathyroidism being the most frequent and dangerous.Materials and procedures: A retrospective analysis collected 27 cases of patients who had a total thyroidectomy complicated by hypocalcemia among 320 patients who underwent a total thyroidectomy throughout the study period, ...

ea0081ep1129 | Thyroid | ECE2022

Management of refractory Graves’ disease

Abir Meherzi , Sghaier Habiba Ben , Bellakhdhar Mouna , Malika El Omri , Houas Jihene , Wassim Kermani , Mohamed Abdelkefi

The goal of this paper is to analyze the factors that cause people to flee medical treatment and to put forth management guidelines. Materials and methodes: This is a retrospective analysis of 27 instances with Graves’ disease that were resistive to medical treatment after escaping from well-conducted medical treatment in the ENT and cervico-facial surgery departments at Farhat Hached Sousse Hospital over a six-year period [2015-2021]. Results: All of the patients were pu...

ea0081ep1130 | Thyroid | ECE2022

Graves’ disease revealing primary biliary cirrhosis (a case report)

Ben Lafqih Maryame , Alahyane Meryam , Rafi Sana , Mghari Ghizlane EL , Nawal El Ansari

Introduction: Liver function abnormalities in hyperthyroidism are common, several abnormalities have been reported: hepatic cytolysis, cholestasis, insufficiency or even non-specific abnormalities. The pathophysiology of hepatic dysfunction secondary to hyperthyroidism is not yet well established. Graves’ disease can be associated with various autoimmune diseases. However, association with Primary biliary cirrhosis has been described in few cases in literature. We report ...

ea0081ep1131 | Thyroid | ECE2022

Coronary insufficiency during hyperthyroidism: Report of six cases

Elleuch Mouna , Chehaider Cyrine , Teber Sawssen Ben , Salah Dhoha Ben , Soomauroo Siddiqa , Charfi Nadia , Mnif Mouna , Mnif Fatma , Rekik Nabila , Kacem Faten Hadj , Abid Mohamed

Introduction: Cardiothyreosis is the consequence of the effects of excess free thyroid hormones on the vascular wall and myocardium. This complication is the most serious aspect of hyperthyroidism. Rhythm disorders and heart failure are the most frequently noted. The prevalence of coronary insufficiency is lower. The aim of this study is to evaluate the characteristics of coronary insufficiency in patients with hyperthyroidism.Method: This is a retrospec...

ea0081ep1132 | Thyroid | ECE2022

Long-term disease recurrence in the adipose tissue and striated muscle of a mimally invasive papillary thyroid carcinoma

Carbone Antonella , Verrienti Antonella , Cito Domenico Savio , Sponziello Marialuisa , Pecce Valeria , Bruno Rocco

Introduction: Differenziated thyroid carcinomas (DTC), particularly papillary thyroid carcinomas (PTCs), usually have an indolent behavior, howewer 10-20% of the patients develop recurrences, following surgery. There are several histological features associated with more frequent recurrences as the hystopathological variants of PTCs, the presence of vascular invasion or lymph node metastases and the presence of extrathyroidal extension (ETE). Case history: a 56yrs old male pat...

ea0081ep1133 | Thyroid | ECE2022

Epidemiological, clinic-pathological, evolutionary profile of noninvasive follicular thyroid neoplasm: About 27 cases

Ouhessaine Sofia , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly defined entity accepted as a tumor precursor.Objective of the study: To describ the epidemiological, clinical characteristics, and the evolutionary profile.Methods: Retrospective study including 27 patients followed for noninvasive follicular thyroid neoplasm collected at the Endocrinology and Diabetology department of Ibn ...

ea0081ep1134 | Thyroid | ECE2022

Severe hyperthyreosis

Petrak Iva , Zibar Tomšić Karin

A 72-year-old male patient presented to the ER because of general weakness, myalgia, frequent paroxysms of atrial fibrillation, shortness of breath, and hoarseness. The symptoms persisted for two months, gradually worsening and causing him to lose weight. At some point, he noticed redness of the sclera and soreness of the eyeballs. Paroxysms of rapid atrial fibrillation have been known for more than 15 years, so he had amiodarone in therapy. His initial laboratory findings sho...

ea0081ep1135 | Thyroid | ECE2022

When unilateral exophthalmos is the only manifestation of graves’ disease: diagnostic and therapeutic issues

Si Amer Sara , Benoumechiara Imene , Fedala Nora Soumaya

Introduction: Basedowian exophthalmos is an inflammatory disease of the orbit of autoimmune origin, potentially threatening with severe functional and psychosocial effects. It is usually accompanied by hyperthyroidism. It constitutes a real diagnostic challenge in patients with euthyroidism, as is the case with our patient.Observation: A 34-year-old young woman with no particular pathological personal or family history. Who initially consults, a year ago...

ea0081ep1136 | Thyroid | ECE2022

Correlation between plasmatic long pentraxin PTX3 and nodular thyroid disease: a preliminary report

Chiari Damiano , Bottazzi Barbara , Leone Roberto , Rodda Giorgia Amy , Pirali Barbara , Branchini Luciano , Zuliani Walter

Introduction: The long pentraxine-3 (PTX3) is a key component of humoral innate immunity that is expressed in various cell types during stress and tissue injury. PTX3 also acts like an oncosuppressor regulating tumor-promoting inflammation and it is implicated in tissue repair and autoimmunity. Autoimmune disease, tissue remodelling and oncogenesis often coexist in the thyroid. PTX3 role in thyroid disease is still unknown. Aim of the study is to evaluate if plasmatic levels o...

ea0081ep1137 | Thyroid | ECE2022

Graves’ orbitopathy: clinical evaluation and therapeutic aspects

AFFES Sofien , Saloua Ben Amor , Mona Rekik , Amar Nadia Ben , Kacem Faten Hadj , Amira Trigui

Introduction: Graves’ disease is a common autoimmune disease that can be complicated by orbital damage sometimes threatening the visual prognosis. We report the case of a patient with Graves’ orbitopathy and we discuss the difficulties of clinical evaluation and therapeutic management.Case report: A 68-year-old woman presented to our department complaining of eye protrusion and progressive vision reduction in both eyes. She has had a history of...

ea0081ep1138 | Thyroid | ECE2022

Autoimmune thyroiditis and hypothyroidism: a personalized medical approach

Martina Ferrari Silvia , Ragusa Francesca , Elia Giusy , Paparo Sabrina Rosaria , Mazzi Valeria , Balestri Eugenia , Botrini Chiara , Patrizio Armando , Antonelli Alessandro , Fallahi Poupak

Autoimmune thyroid diseases (AITD) are organ specific autoimmune disorders with a T-cell-mediated immune attack directed against the thyroid. Hashimoto’s thyroiditis and Graves’ disease are the two principal AITD clinical presentations, which are characterized by hypothyroidism and thyrotoxicosis, respectively. We review the available data in literature about personalized medicine in patients with autoimmune thyroiditis (AT) and hypothyroidism. The synthetic Levothyr...

ea0081ep1139 | Thyroid | ECE2022

The study of lipidic spectrum in the females with ‘subclinical hypothyroidism‘ living in uzbekistan

Mirzaeva Rakhshona , Karimova Dilfuza

Introduction: Hypothyroidism - is a clinical syndrome, which occurs owing to the constant insufficiency of thyroid gland hormones in organisms for a long period of time or as a result of reducing their biological effect as a tissue. Now, hypothyroidism occurs in 7-10 % of females and 2-3 % of men. Subclinical hypothyroidism – is characterized by a gradual aggravating chronic condition of the thyroid gland of immune pathologic character, normal level (T4) of free thyroxin,...

ea0081ep1140 | Thyroid | ECE2022

Sonographic features of autoimmune thyroiditis - a clinical perspective

Anandappa Samantha , Velusamy Anand

Autoimmune Hypothyroidism is a common clinical condition with a suggested prevalence of up to 12% of the population. The subsequent enlargement of the thyroid gland caused by circulating thyroid antibodies can cause neck discomfort warranting a referral to the thyroid ultrasound (USG) clinic. The USG characteristics of autoimmune hypothyroidism can be challenging to grade and the atypical appearances often makes it difficult to exclude a mitotic lesion. We have set forward few...

ea0081ep1141 | Thyroid | ECE2022

Evaluation of calcitonin measurment in fine needle aspitaion biopsy in the diagnostic of medullary thyroid carcinoma

Nour El Houda Khelil , Djamila Meskine

Medullary thyroid carcinoma (MTC) is a rare but relatively serious disease, whose prognosis depends on the stage of the tumor and the quality of the initial surgical treatment. The determination of the plasma calcitonin; cervical ultrasound, and fine needle aspiration biopsy are first line examinations; nevertheless they do not always make it possible to make a certain diagnosis in preoperative; moreover they do not define the MTC nodule in a multi nodular goiter and the metas...

ea0081ep1142 | Thyroid | ECE2022

Application of TI-RADS and BETHESDA classification in the diagnosis of thyroid cancer

Salimova Mohina , Ismailov Said , Shamansurova Zulaykho

Introduction: Malignant tumors of the thyroid gland are common in the field of endocrinology as an oncological disease. The diagnosis of thyroid cancer (TC) is based on sonographic and cytological methods. The widespread use of TI-RADS classification and the Bethesda System for Reporting Thyroid Cytopathology proposed by the American College of Radiology (ACR) and the U.S. National Cancer Institute (NCI) relatively significantly increases diagnostic accuracy. In this study dia...

ea0081ep1143 | Thyroid | ECE2022

Hurthle cell carcinoma of the thyroid gland: diagnostic, therapeutic and prognostic features

Masmoudi Mohamed , Thabet Wadii , Zitouni Chaima , Chebil Ezer , Hasnaoui Mehdi , Mighri Khalifa

Introduction: Oncocytic tumors of the thyroid gland are rare (3-10 %). They are usually benign. Hurthle cell (oncocytic) carcinoma is uncommon: 5 % of thyroid carcinomas. Our aim is to describe the diagnostic, therapeutic and prognostic features of Hurthle cell carcinomas.Materials and Methods: We report 3 cases of Hurthle cell carcinoma treated in our department between 1988 and 2021.Results: Our series included 35 cases of oncocy...

ea0081ep1144 | Thyroid | ECE2022

Thyroid cancer arising from thyroglossal duct cyst: What are the therapeutic strategies?

Masmoudi Mohamed , Thabet Wadii , Zitouni Chaima , Chebil Ezer , Hasnaoui Mehdi , Mighri Khalifa

Introduction: Thyroglossal duct cysts are the most common congenital cervical anomaly. Malignant transformation is very uncommon: 1-1.5%. However, therapeutic strategy is still not codified. Our aim is to describe the therapeutic features of thyroid cancer arising from thyroglossal duct cyst.Materials and Methods: We report 3 cases of thyroid cancer arising from thyroglossal duct cyst, treated in our department between 1996 and 2021.<p class="abstext...

ea0081ep1145 | Thyroid | ECE2022

Thyroid ultrasound characteristics in malignancy prediction

Velkoska Nakova Valentina

Objective: To evaluate the diagnostic accuracy of thyroid ultrasound characteristics of nodules in prediction of malignancy.Material and methods: Retrospectively were analyzed 102 patients who underwent for FNA biopsy of thyroid nodule. All patients were examined by one ultrasound examiner. Size, taller than wide, echogenicity, borders, halo, calcification, and internal vascularity were recorded in all examined nodules. The Bethesda System for Reporting ...

ea0081ep1146 | Thyroid | ECE2022

Papillary carcinoma of the thyroid associated with Marine-Lenarth syndrome: about a case

Bouchenna Amira , Tibouk Abdelghani , Brahim Ghennam , Samia Ould Kablia

Introduction: The Marine-Lenhart syndrome (MLS) is commonly defined as a combination of Graves’ disease and autonomous functioning thyroid nodule (s). the risk of malignancy of these nodules is less than 1% We report a case.Observation: 27-year-old patient, hospitalized for treatment of a basal disease, cervical ultrasound found a 1.5 cm lower left lobe thyroid nodule classified eutirads 4. the sintigraphy found an aspect of diffuse hypercaptive goi...

ea0081ep1147 | Thyroid | ECE2022

Papillary thyroid carcinoma in its cystic form: a case report

Farah Kamel , Guissi Loubna , Rifai Kaoutar , Iraqi Hinde , Gharbi Mohammed Hassane

Introduction: The cystic nodule is an unusual presentation of papillary thyroid carcinoma (PTC), seen in less than 10% of cases. Ultrasound discovery of a thyroid cyst represents less than 5% risk of malignancy. We report the case of a patient followed for papillary thyroid carcinoma in its cystic form.Observation: A 42-year-old patient with no specific history. The patient underwent a right isthmolobectomy for a thyroid nodule. Anatomopathological exami...

ea0081ep1148 | Thyroid | ECE2022

Metastasis of breast cancer in the thyroid gland: Report of two cases

Ferjaoui Mehdi , Bergaoui Emna , Naouar Maroua , Elkorbi Amel , Bouattay Rachida , Harrathi Kaled , Kolsi Naourez , Koubaa Jamel

Introduction: Breast cancer is the most frequently diagnosed cancer in women. Common sites of metastatic spread are bone, lungs and liver. Metastases to the thyroid gland are exceptional.Objectives: The aim of the study is to document two rare cases of thyroid metastasis from breast carcinoma and to specify their clinical, radiological and therapeutic particularities.Methods: Review of 2 clinical cases of thyroid gland metastasis i...

ea0081ep1149 | Thyroid | ECE2022

A female patient with diffuse sclerosing variant of papillary thyroid cancer and background autoimmune thyroiditis

Efstathiadou Zoi , Michou Athanasia , Divaris Efstathios , Gogakos Apostolos , Panagiotou Athanasios , Hytiroglou Prodromos , Kita Marina

Introduction: Diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) represents a rare but rather more aggressive subtype of PTC.Purpose: Description of a patient with DSPC and background autoimmune thyroiditis.Case description: A 33-year-old female patient reported extensive neck swelling that had progressed over several months. The patient had been diagnosed with hypothyroidism attributed to autoimmune thyroiditis, 3 ye...

ea0081ep1150 | Thyroid | ECE2022

Ectopic cushing’s syndrome : a rare cause

Vourlioaki Eirini , Floroskoufi Paraskevi , Kouloukoura Aspasia , Argyropoulou Eleftheria , Stamataki Aikaterini

Introduction: Medullary thyroid carcinoma (MTC) accounts for 1-5% of all thyroid cancers. It is a neuroendocrine tumor arising from the calcitonin-secreting parafollicular cells of the thyroid. In rare cases, the neoplastic cells additionally secrete other substances, such as histamine, serotonin, ACTH, CRF etc, leading to paraneoplastic syndromes.Case report: An 80 year old male presented to our Department with an already diagnosed metastatic MTC. Three...

ea0081ep1151 | Thyroid | ECE2022

Papillary thyroglossal duct carcinoma: report of two cases

Ferjaoui Mehdi , Bergaoui Emna , Naouar Maroua , Elkorbi Amel , Bouattay Rachida , Harrathi Kaled , Kolsi Naourez , Koubaa Jamel

Introduction: The thyroglossal duct cyst is frequently diagnosed in front of an anterior cervical swelling. Its degeneration is possible and observed in 1% to 2% of cases. The clinical feature is not specific, and the diagnosis of malignancy is most often established on final histological examination.Purpose of review: The purpose of this paper is to review the presentation of thyroglossal duct carcinoma and discuss the clinical and therapeutic particula...

ea0081ep1152 | Thyroid | ECE2022

Cholestatic jaundice: think of thyrotoxic hepatitis

Rifai Kaoutar , Guissi Loubna , Ahallat Salma , Iraqi Hind , Gharbi Mohamed Elhassan

Introduction: Liver dysfunction during hyperthyroidism may be secondary to thyrotoxicosis, to an associated liver pathology, or to the medical treatment of hyperthyroidism posing a problem of etiological diagnosis. In this context, we report a demonstrative observation.Case presentation: We report the observation of a 23-year-old female patient, followed for Basedow disease under carbimazole since 1 year, not controlled under medical treatment. During he...

ea0081ep1153 | Thyroid | ECE2022

Role of plasmapheresis in the management of severe amiodarone-induced hyperthyroidism refractory to conventional medical treatment

Garcia Izquierdo Belen , Angulo Macarena Contreras , Grao Laura Armengod , Garcia Gomez Carlos , Garcia Garcia Alvaro , Maroto Azucena Losa , Cabrera Jose Luis Bueno , Serrano Miguel Juan Garcia- Oria , Donoso Encarnacio n , Iglesias Pedro

Introduction: Amiodarone is an antiarrhythmic drug whose high iodine content may influence thyroid function. The first line treatment of amiodarone-induced hyperthyroidism (AIH) is mainly medical. Plasmapheresis has been used in cases of antithyroid intolerance or refractory hyperthyroidism, although clinical experience is poor.Clinical case: We present a case of a patient with structural heart disease and severe AIH refractory to medical treatment who r...

ea0081ep1154 | Thyroid | ECE2022

Stop oral therapy and start later: This is a new perspective for hypothyroid patients who need lifelong intravenous levothyroxine

Pekkolay Zafer

Introduction: Although the replacement route is oral in most hypothyroid patients, euthyroidism cannot be achieved with oral therapy in some patients rarely (1). Although oral levothyroxine is used above the standard dose (1.6-1.9 mg/kg/day), there is resistance to oral therapy if there are laboratory and clinical signs of hypothyroidism (2). Crushing the drug and using it with vitamin C increases the absorption of levothyroxine (3). Rarely, some patients require lifelong intr...

ea0081ep1155 | Thyroid | ECE2022

Refractory hypothyroidism and chronic gastritis

Malad Mohamed , Yassine Errahali , Riznat Malak , Anas Guerboub Ahmed

Introduction: Refractory hypothyroidism is a fairly common situation in the practice of any endocrinologist, being defined by the persistence of hypothyroidism despite adequate doses of replacement therapy with Levothyroxine, generally supraphysiological. We report the case of refractory hypothyroidism under high doses of Levothyroxine.Observation: she was a 54-year-old woman, diabetic Type2, followed for 06 years for papillary carcinoma of the thyroid g...

ea0081ep1156 | Thyroid | ECE2022

Low testosterone: An unexpected journey

Lee Jessica , Casey Edel , Hawkins Anna , Pittathankal Antony , Tanday Raj , Imran Syed , Mlawa Gideon , Nikookam Khash

A 68 year old gentleman referred to endocrinology clinic with a few years history of erectile dysfunction (ED), which manifested as reduced libido and partial erections. Investigations revealed primary hypogonadism with a low morning serum Testosterone of 4.8 (Ref: 7.9-31 nmol/l), raised FSH at 47 (Ref:1.5-12.4 iu/l) LH at 36.8 (Ref: 1.7-8.6iu/l) and normal thyroid function tests (TFTs). The patient declined testosterone replacement therapy following a discussion of pros and c...

ea0081ep1157 | Thyroid | ECE2022

From benign cytology to papillary thyroid carcinoma

Nikookam Yasmin , Grant Bonnie , Shah Usman , Mlawa Gideon , Hawkins Anna , Casey Edel , Pittathankal Antony , Syed Imran , Nikookam Khash

Thyroid cancer is the most common endocrine malignancy with an increasing incidence globally predominantly due to the papillary thyroid carcinoma subtype. It is the 17th and 20th most common malignancy in females and males respectively. In 2018, Cancer Research UK reported 3865 new cases and 400 deaths. Mortality rates are predicted to continue to rise in the UK with an estimated rate of 1 per 100,000 deaths in 2035. We present a 42-year-old female who pr...

ea0081ep1158 | Thyroid | ECE2022

The combination of multi-nodular goiter and Thevenard’s disease: about 3 familial cases

Abidi Ihssane , Rifai Kaoutar , Hinde Iraqi , Gharbi Mohamed Elhassan

Introduction: Thevenard’s disease is a sensory neuropathy with a type of ulcerative-mutilating acropathy of progressive course. It has a hereditary character with autosomal dominant inheritance. It is a scarce disease, which usually affects feet but can also affect hands. It causes disorders of thermoalgesic sensitivity, leading to painless ulcerations at the pressure points and then bone deformities with osteoarticular destruction and ‘cubic foot‘ appearance. R...

ea0081ep1159 | Thyroid | ECE2022

Role of iratherapy in the treatment of Graves’ disease in children: a case report

Chaimae Kadiri , Hassan Lachkar

Introduction: Graves’ disease is a rare and severe disease in children with a marked female predominance. The diagnosis is made in front of a very suggestive clinical picture most often grouping together a goiter, an exophthalmos and a picture of thyrotoxicosis, confirmed biologically by the presence of hyperthyroidism with positive anti-TSH receptor antibodies and radiologically by diffuse, homogeneous, hypervascular goiter. There are three essential therapeutic weapons:...

ea0081ep1160 | Thyroid | ECE2022

Surgical treatment of Graves’ disease

Masmoudi Mohamed , Regaeig Marwa , Thabet Wadii , Chebil Azer , Hasnaoui Mehdi , Mighri Khalifa

Introduction: Graves’ disease is an autoimmune disease of the thyroid gland, which represents the most common cause of hyperthyroidism, accounting for 50 - 80% of all cases. Three treatment options are available for Graves’ disease: anti-thyroid drugs, radioactive iodine and thyroidectomy. But therapeutic management is still controversial. The aim of our study is to discuss, after a review of the literature, the role of surgery in the treatment of Graves’ diseas...

ea0081ep1161 | Thyroid | ECE2022

Case report: Amiodarone-induced thyroid dysfunction

Akid Faten Haj Kacem , Trimeche Oumeyma , Missaoui AbdelMouhaymen , Salah Dhoha Ben , Fatma Mnif , Charfi Nadia , Mnif Mouna , Majdoub Nabila Rekik , Elleuch Mouna , Abid Mohamed

Amiodarone is considered by many the most potent antiarrhythmic drug. The other side of the coin is that it’s associated with many side effects including disturbances in the thyroid function, which can be seen in 14 to 18 % of the cases (1). This case is about a 56-year-old male patient with a history of mitral valve disease who was on Amiodarone for 3 years. His personal history was notable with Epilepsy of unknow etiology for which he was on sodium valproate. During fol...

ea0081ep1162 | Thyroid | ECE2022

Hypothyroidism : the interest of thyroid hormone test

Mouelhi Yasmine , Khessairi Nadia , Terzi Ameni , Grira Wafa , Yazidi Meriem , Chihaoui Melika

Introduction: Hypothyroidism is a common endocrine disease with reduced systemic metabolism and its treatment consists on hormonal supplementation. However, despite concurrent replacement therapy with high doses of L-thyroxin, some patients might be seen with clinical and biochemical evidence of hypothyroidism. We report a case of persistent hypothyroidism on high dose of levothyroxin.Case presentation: It was a 41-year-old female, with a history of recu...