ECE2022 Eposter Presentations Thyroid (219 abstracts)
Long-term thyroid function in women diagnosed with subclinical hypothyroidism in pregnancy
Rocío Revuelta 1 , Ana Castro 1 , Belen Martínez 1 , Andrea Cruz 1 , Maria-Piedad Picazo-Perea 2 , Esther Martin-Torres 2 , Aurora Lopez-Martos 2 & Almudena Vicente 1
1Toledo University Hospital, Endocrinology and Nutrition, Toledo, Spain; 2Toledo University Hospital, Biochemistry, Toledo, Spain
Introduction: Subclinical hypothyroidism (SCHT) in pregnancy has been associated with adverse obstetric and perinatal outcomes. However, few studies have investigated the evolution of postpartum thyroid function in women first diagnosed with SCHT in pregnancy (gestational SCHT).
Objective: To determine the evolution of thyroid function (TF) and the clinical and biochemical factors related to the long-term persistence of hypothyroidism (HT) in women with gestational SCHT.
Methods: Gestational SCHT was defined as the presence of TSH values above the upper limit of the specific range in our population (0.21-3.8 mcU/ml) determined in the first trimester (1T). We reviewed the medical records of women diagnosed with SCHT in our Health Area in 2016. We compared the clinical and biochemical characteristics of pregnant women diagnosed for the first time with SCHT in pregnancy, with TF data at least 6 months postpartum.
Results: Thyroid dysfunction screening was performed in 3821 women. 293 met SCHT biochemical criteria (7.66%). Of 140 women diagnosed with gestational SCHT, 106 had long-term TF data. The mean age was 31.4 ± 5 years, being 61.5% older than 30 years. The prevalence of persistent hypothyroidism (HT) at the end of the follow-up was 48.1%(n= 51), being significantly more frequent in women with positive anti-TPO antibodies (Ab) (61.4% vs 38.6%; P<0.05) and TSH greater than 10 in 1T (85.7% vs 45.4%; P<0.001).
Conclusions: 1. In our study, almost half of the women with gestational HTSC present long-term persistent HT, being more frequent in those with positive anti-TPO and/or TSH higher than 10 in the 1T. 2. It would be advisable to monitor these women, especially when planning subsequent pregnancies.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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