Endocrine Abstracts

Objective: Osteoporosis and osteopenia (OS/OP) are frequent in patients with cortisol-producing adrenal adenomas (CPA) associated with severity of cortisol excess (CE). However, the relationship between OS/OP and CE severity considering sex differences is unknown.Patients and Methods: This was a retrospective cross-sectional observational study conducted as a part of the Advancing Care and Pathogenesis of Intractable Adrenal Disease in Japan (ACPA-J) stu...

A 50-year-old peri-menopausal lady has had a background history of hypertension on single-agent antihypertensive medication (ACEI), chronic headache, recurrent collapses, and panic attacks for the past 14 years. She has been visited by her GP frequently and performed countless blood tests including FSH, LH, and TSH which confirmed that her symptoms were neither related to menopause nor hyperthyroidism. She also presented to the Emergency Department a dozen times and called par...

Introduction: In Russia, full-scale studies aimed at assessing the incidence of endocrine autoimmune diseases (eAID) in adult patients with vitiligo have not been conducted.Objectives: analysis of occurrence of eAID in patients with vitiligo.Methods: 1) The first part of the study included 39 patients aged 19-73 years with endocrine pathology and vitiligo, who were initially examined in Endocrinology Research Centre. 2)The second p...

Aim: Autonomic cortisol secretion (ACS) is a clinical picture without overt signs of Cushing’s Syndrome despite adrenal adenoma and ACTH-independent cortisol secretion. These patients, who currently do not have a standard treatment, are followed up, especially for known comorbidities of hypercortisolemia such as obesity, diabetes mellitus (DM), hypertension, osteoporosis, and hyperlipidemia. However, it remains unclear how long the patients will be followed and when the t...

Introduction: Pheochromocytomas are catecholamine producing tumors which arise from chromaffin cells within the adrenal medulla. Silent pheochromocytomas are rare entities that do not present with the classical symptoms commonly seen in catecholamine-secreting tumors. Case report: We report a case of 70-year-old-woman patient who presented with left sided abdominal pain and discomfort for 6 months. A preoperative Computed tomography (CT) scan showed a hu...

We report a case of 39-year-old woman presenting with sudden severe abdominal pain and vomiting. She had a past medical history of anti-phospholipid antibody syndrome (APLS) diagnosed in the United States (US) 20 years ago. She had multiple episodes of vomiting over the last 10 years and was diagnosed with cyclical vomiting as investigations including CT abdomen and endoscopy did not reveal a structural cause. She was taking warfarin for APLS. She was haemodynamically stable a...

64 year old male with known hypertension presented with fatigue and mild vertigo to the emergency department. Blood pressure was 110/65 mmHg. Physical examination revealed bilateral inspratory crackles with bilateral pedal oedema. There was not any skin discolourisation or bruises. Patient history indicated a suspected lung malignancy but pathological diagnosis was yet to be concluded. Laboratury test showed that sodium level was 117 mEq/l, potassium level was 5.2 mEq/l, venou...

Background: Post surgery hypocalcemia is the most common sequel of thyroidectomy. An accurate prediction of hypocalcemia in the immediate postoperative period would enable the selection of patients for appropriate treatment and facilitate early discharge. Objective: This study aims to investigate the prevalence of hypocalcemia after thyroidectomy and to identify potential risk factors. Methods: This is a retrospective cohort study ...

Introduction: Of interest are cases of osteoporosis of unknown etiology after a recent delivery.Matherials and methods: A 33-year-old woman complained of frequent fractures of the bones of both feet (four times in the last year) after the birth of her third child. For the woman, this was the fourth pregnancy, according to her, after the birth of her second child, she had pain in the lower back, which aggravated with physical exertion (at 24 years old).</...

Introduction: Osteoporosis is a common metabolic bone disease characterized by reduced bone mass and increased risk of fragility fractures. The pathogenesis of this disease is complex and influenced by multiple risk factors, where genetic factors play an important role. Menopause predisposes women to osteoporosis due to declining estrogen levels. Osteoporosis and iron metabolism have an important relationship. Iron overload suppresses osteoblast formation and stimulate osteocl...

An 89 years old caucasian female patient with antecedents of hemithyroidectomy in 2016 due to benign nodular disease, and actually suplemented with 0.1 mg/day of levothyroxine, was referred to the Endocrinology consultation because of a primary hyperparathyroidism diagnosed in the sequence of the study of an episode of nephrolitiasis that happened in 2012 and a diagnosis of osteoporosis that was established in 2017. A 99mTc-Sestamibi revealed an augmented right inferior parath...

Background: In recent years, the morbidity of obesity has been increasing rapidly worldwide, which is a major risk factor for type 2 diabetes mellitus (T2DM). Obesity, mainly characterized by abnormal and excessive white adipose tissue accumulation, is the most common cause of insulin resistance (IR), where the insulin target tissues fail to respond normally to circulating insulin. However, the precise mechanism by which obesity affects insulin resistance in the major insulin ...

Introduction: In the Covid-19 era mass media present people worldwide, including in Greece, to transiently flock to green spaces and parks. A study from the Western United States in 2020, indicated that indeed, park visitation may have increased by 20% compared to baseline (the immediate pre-Covid-19 period). The Google mobility index (GMI) is based on location data/visits - from smartphone users - to various areas; among areas of mobility the GMI can focus specifically on vis...

Purpose: To assess the level of biomarkers of early kidney damage (urinary and plasma cystatin C) in patients with prediabetes and to characterize their association with risk factors for the development of nephropathy.Materials and methods: The object of the study were 60 patients (32% men, 68% women) with early disorders of carbohydrate metabolism (impaired fasting glycemia (IFG) and impaired carbohydrate tolerance (IGT), WHO criteria, 2009). The mean a...

Introduction: tests alternative to the fasting test are necessary for the diagnosis of numerous causes of non-diabetic hypoglycaemia (NDH), that not provoked by starvation (postprandial hypoglycemia), such as insulin autoimmune syndrome (IAS) and noninsulinoma pancreatogenous hypoglycemia syndrome (NIPHS). However, there is no consensus on the most optimal test (prolonged oral glucose tolerance test (pOGTT) or mixed meal test (MMT)) in this cohort of patients.<p class="abs...

Introduction: Dietary practices are essential in diabetes control and acquiring HbA1c target. The aim of our work is to evaluate the prevalence of dietary education practice in a type 2 diabetes population and its associated factors.Methods: Cross-sectional study enrolling 84 type 2 diabetes patients followed up in the outpatient endocrinology department. The data was collected through a questionnaire in face-to-face interviews with patients. Age, body m...

Forty-one vitamin D deficient women (aged 26-75 years, mean 56.2, median 57) were treated with Vitamin D3 (50000 IU/week for 1.5 month and 25000 IU/week for another 1.5 month). Before treatment their serum 25(OH)D was 17.3&pm;6.1 ng/ml (mean&pm;SD) and after treatment 37.0&pm;7.5 (P<0.0001). Their HOMA-IR was 2.2&pm;1.1 before and 2.3&pm;1.1 after (P=NS), serum insulin 9.0&pm;4.2 mIU/l before and 9.6&pm;4.5 after (NS), glucose 96.2&pm;8.2 mg/dl before and...

Background: Since the last decade, the disease pattern has significantly changed around the world. Non-communicable diseases, most commonly diabetes mellitus, have become the main threat to global health. The incidence of diabetes mellitus type 2 (DM2) is rising steadily, accounting for about two-thirds of deaths in Germany. Based on a prevalence of 9 million diabetic patients per year, DM2 constitutes a considerable medical and economic burden in Germany. However, the healthc...

Objective: Previously, we identified that knockdown of calcium/calmodulin-dependent serine protein kinase (Cask) in β cells in vitro resulted in decreased insulin secretion. We then used the Cre-loxP system to specifically delete the Cask gene in β cells of mice, and the mice exhibited impaired glucose tolerance and glucose-stimulated insulin secretion under a normal chow diet. However, under a high-fat diet (HFD), the insulin sensitivity a...

Introduction: Diabetic nephropathy (DN) is a severe complication of type 1 diabetes mellitus (T1DM) and has become common primary disease leading to end-stage renal disease worldwide. Abnormalities in lipid metabolism is very important in the progression of renal damage in patients with T1DM.Aim: to assess the relationship between lipid abnormalities and diabetic nephropathy in type 1 diabetes mellitus patients. Methods: we perform...

Background: Obesity is a widespread disease that causes chronic low-grade inflammation and related chronic diseases such as steatohepatitis, metabolic syndrome, diabetes mellitus (DM), and cancer. It is known that weight loss positively affects life expectancy by reducing obesity-related complications. Therefore, effective management of particularly morbidly obese patients is getting prominent in clinical practice. Bariatric surgery (BS) is the main effective treatment option ...

Background: Uncontrolled diabetes mellitus in ketoacidosis, as well as other kinds of metabolic acidosis, are major risk factors for mucormycosis. As the frequency of diabetes mellitus increase, so does the number of individuals at risk for this lethal infection. However, a lack of symptoms could lead to a delay in diagnosis. The aim of this paper is to study the clical features of otologic mucomycosis and to analysis the impact ketoacidosis the disease’s course.<p cl...

Background: Obesity is one of the most critical problems nowadays, its frequency and consequences. Since the risk of morbidity and mortality increases in obese individuals, lifestyle changes, pharmacotherapy, and bariatric surgery (BS) methods are used for treatment. BS is generally considered the most effective method to treat morbid obesity. However, it is known that thyroid function has a role in weight regulation, the effect of preoperative thyroid function on weight loss ...

Introduction: Primary hypobetalipoproteinemia corresponds to a series of congenital disorders that have a variable incidence from 3.2% to less than 1 in 1 million, depending on the type of genetic mutation. The diseases that comprise it occur due to different types of mutations in genes that will encode important proteins at different stages of lipid metabolism. Individuals with determinant mutations of severe phenotypes, such as Bassen-Kornzweig syndrome, as known as Abetalip...

Background: Spinal cord injury (SCI) can lead to dramatic physiological changes which can be a factor in developing secondary health conditions and might be reflected in biomarker changes in this elevated risk group. We focused specifically on the endocrine and inflammation profile differences between SCI and able-bodied individuals (ABI). Objectives: To determine the differences in inflammatory and endocrine markers profiles between individuals with SCI...

Introduction: The prevalence of diabetes mellitus (DM) continues to increase worldwide. Diabetic retinopathy (DRP) is one of the most common complications of Type 2 DM. Recently, the effect of thyroid hormones on diabetic microvascular complications has gained much attention. This relationship is explained by the important effects of thyroid hormones on endothelial function. There are studies investigating the relationship between TSH and diabetic nephropathy and DRP. There ar...

Objective: Studying the prevalence of diabetes mellitus is necessary to assess the epidemiological situation in the regionAim: To study the prevalence of diabetes mellitus in the Tashkent region.Methods: The source of information was the data of the statistics office of the endocrine dispensary of the Tashkent region for the period 2018-2020. For the statistical processing of the data, the Microsoft Excel 2010 program was used....

Introduction: Magmas encodes for an integral constituent of the TIM23 translocase complex located in the mitochondrial inner membrane that drives proteins from the intermembrane space into the mitochondrial matrix by functionally interacting with Tim14. We previously demonstrated that Magmas silencing is able to sensitize ACTH-secreting mouse pituitary adenoma cells to pro-apoptotic stimuli, reduce DNA synthesis, accumulate cells in G0/G1 phase with concomitant decrease in S p...

Background: Non-islet-cell tumor hypoglycemia (NICTH) is a rare but severe complication of malignancy. NICTH has been related to the production of IGF II by tumours of mesenchymal or epithelial origin. It gives rise to frequent episodes of severe hypoglycemia and can have negative impact on quality of life. This case report describes a case of Non Islet cell tumor hypoglycemia due to hepatocellular carcinoma with hypoglycemia as the first presentation.Cl...

Background: Insulin autoimmune syndrome (IAS) or Hirata disease, is a rare cause of hyperinsulinemic hypoglycemia characterized by autoantibodies to endogenous insulin in individuals without previous exposure to exogenous insulin. IAS has been described as a form of type VII hypersensitivity, characterized by the presence of autoantibodies against a circulating antigen. The cornerstone of the IAS is the appearance of circulating insulin autoantibodies (IAA), which have a patho...

Background: Previous studies show that lead levels are closely related with obesity, and severe weight reduction in obese women increases skeletal bone mobilization and blood lead levels especially postmenopausal women. However, it is under the curtain if blood lead level is associated with menopause, weight recycling in women until now.Methods: We assessed weight, height, waist circumferences and obtained past medical histories, blood lead levels as wel...

Introduction: Alterations in glucose homeostasis and diabetes mellitus (DM) are the most common metabolic comorbidities in acromegaly. DM has been reported in 16–56% of patients with acromegaly. It is estimated that 20% of patients with acromegaly have developed DM before the formal diagnosis of acromegaly. We report a case of a patient with acromegaly secondary to a pituitary macroadenoma who presented with diabetes.Case report: A 47- year-old fema...

Introduction: Growth Hormone deficiency (GHD) is a rare etiology of short stature. The lack of early diagnosis and adequate treatment have adverse consequences, especially the small final height with the resulting psychological impact. The aim of this study is to identify some of the predictive factors influencing stature gain during the first year of GH therapy.Matherials and methods: This is a retrospective and analytical study regarding 36 children wi...

The article presents a case of permanent central diabetes insipidus (CDI) in a patient after severe traumatic brain injury (TBI) in traffic accident. A 16-year-old boy entered to a medical facility in the coma (6 points of Glasgow Coma scale (GCS)). Diagnosis: acute TBI; severe cerebral contusion; subarachnoid hemorrhage; depressed comminuted cranial vault fracture; basilar skull fracture; visceral contusion. CDI diagnosed three days after injury when polyuria and hypernatremi...

Introduction: Pilomyxoid astrocytoma (PMA) is a rare entity usually described in the hypothalamic-chiasmatic area. It generally concerns infants and very young children. Clinical presentation is not well-defined. But, the therapists should be aware of diencephalic syndrome as an unconventional cause of failure to thrive during early childhood. We report a case of PMA exhibited by failure to thrive;which is a rare outlined association in the litterature.C...

Introduction: Growth hormone deficiency (GHD) is a non-exceptional cause of short stature. Hormonal evaluation and hypothalamic-pituitary MRI are essential to establish the etiological diagnostic. The objective of our study is to assess the different pituitary lesions found in a group of children with GHD.Patients and methods: This is a retrospective longitudinal study of 36 cases of GHD who underwent pituitary MRI examination collected in the Endocrinol...

Introduction: Most pituitary adenomas are benign. However, there are invasive forms with rapid growth rate and particular histological signs (atypical adenomas), making them considered pituitary carcinomas without metastases.Observation: A 63-year-old patient was followed for 10 years for Cushing’s disease in the pituitary macrodenoma. Clinical evaluation found Cushing syndrome, pituitary tumor syndrome associated with diplopia, and trigeminal neura...

Aim: To study the relationship between the age of patients and the dynamics of the size of somatotropinomas after radiation therapy (RT).Materials and methods: The object of the study is 94 patients with acromegaly who received RT. The average age was 43.8 &pm; 10.4 years. The patients were divided by age into the following groups: Group I 16-29 years old (9 patients); II group 30-44 years old (44 patients); III group 45-59 years old (34 patients); IV gr...

Introduction: Acromegaly is a chronic disease that requires continuous follow-up and examinations over time. During the COVID-19 pandemic outbreak many endocrinological scientific societies recommend to reduce pituitary patient access to hospital facilities to decrease risk of infection. Aim: The aim of our study is to evaluate the impact of restrictions on outpatient access in the clinical management of the patient with acromegaly during COVID19 pandemi...

Infundibulo-neurohypophysitis is an inflammation of the pituitary stalk and posterior gland. It is an autoimmune disease characterized by lymphocytic infiltration of the pituitary gland. It occurs mainly at the end of pregnancy or in the postpartum period, and is related to autoimmune diseases, including autoimmune thyroiditis. But it is rarely related to Gougerot-Sjogren syndrome, which is an autoimmune connective tissue disease with lymphocytic infiltration of the exocrine g...

Introduction: Hypovitaminosis D is prevalent in children with growth hormone deficiency. Infants and young children are special risk groups of vitamin D deficiency due to their rapid growth with high nutritional requirements. The lack of early diagnosis and adequate treatment have adverse outcomes. It impairs particularly bone maturation and increases metabolic risk. The purpose of our study is to assess the vitamin D status of children followed up for GHD in the Endocrinology...

Background: Preeclampsia (PE) continues tochallenge both the clinicians and researchers worldwide, as the existing knowledge on its etiopathology does not come up with an efficient and foolproof treatment regime due its progressive nature and uncertain diagnosis and prognosis. In this context, miRNAs represent a potential therapeutic target and a diagnostic tool.Objectives: Circulating microRNAs present in maternal blood play an important role in the eti...

Aim: Infertility, defined as the non-achievement of pregnancy by a couple after 12 months of free sexual intercourse, affects 4 - 17% of couples worlwide. In 20% of cases, the cause is found exclusively or mainly in the man. The purpose of this study is to evaluate infertility as a risk factor for increased psychological stress.Material and Methods: A case – control study was conducted in which the levels of psychological stress of men with infertil...

Introduction: The treatment with growth hormone (GH) plays an essential role in the Turner syndrome (TS) management. This study evaluated its efficacy in improving adult height (AH) and metabolic parameters.Material and methods: We retrospectively analysed auxological, biochemical, genetic and pharmacological parameters of 56 girls with confirmed TS. They were categorised according to their karyotype as X monosomy (62%), isochromosome (17%), X mosaicism ...

Introduction: Nodular thyroid pathology is very frequent. Its exploration requires a clinico-biological evaluation, a cervical ultrasound to look for the ultrasound criteria of malignancy allowing to classify the thyroid nodules according to the EU-TIRADS classification in order to orientate the diagnosis and to indicate the Fine needle aspiration, to finally allow a targeted management. The aim of our study is to investigate the correlation between the EU-TIRADS classificatio...

Hyperthyroidism is a clinical situation characterized by an excess of thyroid hormones in the circulation, the most common etiology of which is Graves’ disease. Its treatment is based on ATS, iodine 131 and surgery. The iratherapy, object of our study, is a treatment of current practice. It is a simple and radical treatment whose goal is to switch to euthyroidism or hypothyroidism. In case of failure or recurrence, a 2nd or even a 3rd cure is prescribed. We conducted a re...

Differentiated Thyroid Cancer (DTC) is the most common malignant tumor in endocrinology, being the papillary subtype frequently found. The DTC is usually indolent and with a more favorable clinical prognosis of survival in 10 years, which has been diagnosed more frequently after the development and dissemination of complementary detection methods, according to the world literature. However, access to imaging exams with increasing resolving power makes a large number of low-ris...

Introduction: Thyroid pathology, particularly nodular, is very frequent. It is in most cases benign, thyroid cancer remains rare (5% of nodules). Thyroid ultrasound is the reference examination and should be performed in all patients with known or suspected thyroid nodules. It will allow the detection, diagnosis, search for signs of malignancy and monitoring of these nodules. The aim of our study is to investigate the correlation between the ultrasound signs of malignancy and ...

Objectives: Primary - Study of Correlation between Serum Osteoprotegerin, and Biomarkers of Bone Metabolism in Patients with treatment-naive Graves’ Disease (GD). Secondary- Serum level of Osteoprotegerin, TNF alfa and Biomarkers of Bone Metabolism in Patients 3 months after treatment of GD with methimazole (MMI).Material and Methods: A total of thirty-five treatment-naive newly diagnosed GD were recruited for the study, most of them were female. Al...

Introduction: COVID-19 in Kosovo was introduced in March 2020 as a global pandemic started in Wuhan, China in December 2019. The link between COVID-19 and diabetes was seen in the first cases but was if this disease is interfering in other endocrine glands was still unclear. In May 2020 we found the first case of subacute thyroid immediately after COVID-19 which case trigger us for further observation of its spread.Aim: To investigate the clinical forms ...

Background: Graves’ Disease usually responds well to medical treatment with thionamides. However, in some cases, it fails to respond to this treatment, even at maximum doses. A few reported cases have shown that colestyramine helps to restore normal thyroid function when added to the ongoing anti-thyroidal medications in refractory thyrotoxicosis. We reported a case of relapsing refractory Graves’ disease, in which colestyramine has helped to restore normal thyroid f...

Introduction: Epstein-Barr virus (EBV) is a well-known human tumor virus with a very high prevalence in the population, this virus is associated with epithelial and lymphoid malignancies, including lymphoepithelioma carcinoma of thyroid. This subtype of thyroid carcinoma is characterized by histologic features similar to those of undifferentiated carcinoma of the thyroid. Case Report: A 17-year-old male patient, his medical and family histories were non-...

Introduction: Oncocytic tumors of the thyroid include adenomas and carcinomas. The distinction between malignancy and benignity represents a major difficulty on the histological level. From this aspect arise constraints in the attitude therapy to adopt.Material and methods: we present one rare case of an oncocytic carcinoma of the thyroid with laryngotracheal invasion in a 54 male patient operated in ENT department of Farhat Hached hospital of Sou...

Introduction: Hypothyroidism is considered refractory to oral levothyroxine substitution, when there is biochemical (serum level of TSH (thyroid stimulating hormone) above the upper target level) or clinical evidence of hypothyroidism, despite increasing dosages of oral levothyroxine beyond 2.5 μg/kg daily. In these circumstances, further increments in the dosage of levothyroxine may not always be the most appropriate intervention. In such a situation, physicians need to ...

Background: Primary thyroid non Hodgkin’s lymphoma (PT-NHL), which defined as a lymphoma occurring in the thyroid gland with or without the involvement of regional lymph nodes, is a quite rare pathologic entity, accounting for 1,3-1,5 % of thyroid neoplasm, and 0,5% of lymphoma. there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid gland. Due to this rarity and non specific clinical presentation, it seems essentiel to better under...

Background: To study the diagnostic difficulties, the clinical characteristics, as well as the therapeutic modalities of this entity.Material and method: Report a case of oncocytic carcinoma of the thyroid of aggressive evolution collected in the ENT department and CCF Farhat Hached in Sousse. Result: This is a 54-year-old patient, with no notable history, who was operated on in 2012 for a large goiter evolving for 3 years previous...

Introduction: Amiodarone is an effective drug for treating heart arrhythmias. High iodine content and specific metabolism of this drug, in 15-20% of patients lead to thyroid function disorder. Amiodarone induced thyrotoxicosis (AIT type 1 or type 2) usually occurs during the use of the drug, while it is rare after the drug cessation.The aim: A case report of a patient with type 2 AIT that manifested after the cessation of short-term amiodarone treatment....

Hyperthyroidism is a condition with the overproduction of thyroid gland’s hormones. One of the treatment option is methimazole, blocking the synthesis named hormones, usually before thyroid surgery or radioactive iodine therapy. I report a 68-year old woman who admitted to hospital in November 2021. after a hematological examination due to leucopoenia and agranulocytosis. She is been treating the hyperthyroidism last 12 years with methimazole. In the beginning she was tak...

Introduction: -Thyroid disorders can predate or develop during pregnancy. -The effects on the fetus vary depending on the disease and the drugs used for treatment. But usually, untreated or undertreated hyperthyroidism can lead to harmful complications.Case report: It’s a 26-year-old patient with a history of goiter since childhood, history of goiter in the mother; grandmother and maternal aunt. the patient is 18 weeks pregnant, the pregnancy is unp...