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Endocrine Abstracts (2022) 81 EP1104 | DOI: 10.1530/endoabs.81.EP1104

Hedi Chaker Hospital, Department of Endocrinology, Sfax, Tunisia


Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism in pediatric patients, up to 95% in some studies.

Observation: We report the observation of a 6-year-old female who consulted for a behavioral disorder made of agitation and lack of concentration. She had a family history of autoimmune thyroid disease. On examination, an accelerated statural growth rate of +2DS was noted. She had a significant palpebral retraction without exophthalmia. A biological check-up showed a blocked TSH level at 0.01µU/ml associated with a high T4 at 26.4 pmol/l. In addition, TSH receptor antibodies blokers (trab) were positive at 17.8 U/l for a normal value (NV) of less than 1.5. Anti-thyroperoxidase antibodies were positive at 148 U/l (NV<20U/l). The thyroid ultrasound was normal with a normal volume and homogeneous gland. The diagnosis of Graves’ disease was retained and a treatment with methimazole was started at a dose of 0.5 mg/kg/d. The thyroid check-up 3 months later was normal. The treatment is in progress.

Conclusion: GD is a rare condition in children and affects mostly older children with a clear female predominance. Although rare, GD remains the most frequent cause of hyperthyroidism in children. Diagnosis is easier if exophthalmia is present, which is a very specific sign of this condition. However, palpebral disorder is the most common as exophthalmia is less frequent in children. Medical treatment is based on synthetic antithyroid drugs.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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