Oral Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1

ea0081oc1.1 | Oral Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Clinical characteristics and outcomes in hospitalized COVID-19 patients with and without diabetes at Vilnius University Hospital Santaros Klinikos (VUHSK)

Visockiene Zydrune , Jakubkevicius Valentinas , Alekniene Modesta , Šiauliene Laura , Mekionyte Gerda , Scerbinkinaite Joana

Background: Studies suggest that diabetes mellitus (DM) is associated with greater risk of developing severe forms of COVID-19 and mortality.Aims: To compare clinical characteristics and outcomes in hospitalized COVID-19 patients with and without DM.Methods: A single-center, retrospective, observational study included adult patients with laboratory-confirmed COVID-19 treated at VUHSK between 2020-01-01 and 2021-03-31. Patients were...

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ea0081oc1.2 | Oral Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Glucose control and mortality in critically Ill patients, based on real world evidence

Dafoulas George , Kalamaras Ilias , Votis Konstantinos , Bargiota Alexandra

Objective: Published results of reduced morbidity and mortality with tight Glycemic Control of critical patients could not be reproduced in large prospective trials. Glycemic goals according to current respective guidelines include a target blood glucose range 140-180 mg/dl, while lower blood glucose targets may be appropriate for some patients. This study aims to provide real world evidence to this field.Methods: We performed a retrospective study using...

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ea0081oc1.3 | Oral Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Canakinumabin patients with COVID-19 and type 2 diabetes (CanCovDia) – a multicentric, randomised, double-blind, placebo-controlled phase 3 trial

Hepprich Matthias , Mudry Jonathan , Gregoriano Claudia , Jornayvaz Francois R , Carballo Sebastian , Wojtusciszyn Anne , Bart Pierre-Alexandre , Chiche Jean-Daniel , Fischli Stefan , Baumgartner Thomas , Cavelti-Weder Claudia , Beuschlein Felix , Braun Dominque L , Gunthard Huldrych F , West Emily , Conen Anna , Isenring Egon , Bucklar Gabriela , Aubry Yoann , Dey Ludovic , Muller Beat , Schutz Philipp , Cattaneo Marco , Hunziker Patrick , Donath Marc Y

Background: Patients with type 2 diabetes and overweight have a chronic activation of the innate immune system possibly explaining the increased risk of a hyperinflammatory response and severe COVID-19. We aimed to test whether blockade of interleukin-1β(IL-1β) using canakinumab improves clinical outcome.Methods: CanCovDia was a multicenter, randomised, double-blind, placebo-controlled trial to assess the efficacy of canakinumab plus standard-o...

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ea0081oc1.4 | Oral Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

β-Caryophyllene, a dietary CB2 receptor selective cannabinoid mitigates myocardial fibrosis in a mice model of diabetic cardiomyopathy

Hashiesh Hebaallah Mamdouh , Sheikh Azimullah , Meeran MF Nagoor , Al Kaabi Ahmed , Sadek Bassem , Adeghate Ernest , Ojha Shreesh Kumar

β-Caryophyllene, a dietary CB2 receptor selective cannabinoid mitigates myocardial fibrosis in a mice model of diabetic cardiomyopathyBackground and aim: Diabetic cardiomyopathy (DCM), a cardiac complication in diabetes is characterized by abnormal cardiac function accompanied with myocardial fibrosis. In recent years, the cannabinoid type 2 receptors (CB2) emerged as a crucial therapeutic target for diabetes and its complications. The downregulatio...

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ea0081oc1.5 | Oral Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Associations between alcohol consumption and body fat distribution in type 1 diabetes

Parente Erika B. , Lampenius Ina , Harjutsalo Valma , Feodoroff Maija , Forsblom Carol , Groop Per-Henrik

Background: Increased alcohol intake is associated with several health disorders. However, its impact on body composition is still controversial and data regarding this subject in people with type 1 diabetes (T1D) are limited. We have shown that central obesity is associated with diabetes complications in T1D, and now, we investigated whether the alcohol consumption is associated with body fat distribution in adults with T1D from the Finnish Diabetic Nephropathy (FinnDiane) St...

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Endocrine Abstracts

European Congress of Endocrinology 2022