Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Oral Communications

Oral Communications 3: Thyroid 1

ea0081oc3.1 | Oral Communications 3: Thyroid 1 | ECE2022

Real world prospective application of ATA guidelines in over 500 aspirated thyroid nodules: Is it time for changing the size cut-offs for FNA?

Ioakim Stamatina , Zavros George , Picolos Michalis , Syed Akheel , Kyriacou Angelos

Introduction: The 2015 American Thyroid Association (ATA) guidelines on the management of thyroid nodules and cancer recommend specific size cut-offs for fine needle aspiration (FNA) cytology. We assessed the correlation between sonographic and cytological stratification as per the guidelines, with emphasis on the size cut-offs.Methods: In a ‘real world’ prospective study, we sonographically stratified 562 thyroid nodules prior to performing ul...

ea0081oc3.2 | Oral Communications 3: Thyroid 1 | ECE2022

Cabozantinib versus placebo in patients with radioiodine-refractory differentiated thyroid cancer (DTC) who have progressed after prior VEGFR-Targeted yherapy: updated results from the phase 3 COSMIC-311 trial and prespecified subgroup analyses based on prior therapy

Durante Cosimo , Brose Marcia , Robinson Bruce , Sherman Steven I , Jarzab Barbara , Lin Chia-Chi , Vaisman Fernanda , Hoff Ana O , Hitre Erika , Bowles Daniel W , Sen Suvajit , Patel Purvi , Keam Bhumsuk , Capdevila Jaume

Background: At a preplanned interim analysis (median follow-up 6.2 months) of the double-blind, phase 3 COSMIC-311 trial (NCT03690388), cabozantinib significantly improved progression-free survival (PFS) vs placebo (HR 0.22, 96% CI 0.13-0.36; P<0.0001) in 187 patients with previously treated radioiodine-refractory DTC (Brose, Lancet Oncol; 2021). Patients must have received lenvatinib or sorafenib and progressed during or after 1-2 prior VEGFR inhibitors. We prese...

ea0081oc3.3 | Oral Communications 3: Thyroid 1 | ECE2022

Adata-driven approach reveals emerging risk factors for recurrent and persistent differentiated thyroid cancer

Gentili Michele , Grani Giorgio , Siciliano Federico

Background: The appropriate risk stratification of patients with differentiated thyroid cancer (DTC) is crucial because most cases have an indolent behavior and need a conservative approach. One of the most widely used tools is included in the American Thyroid Association (ATA) Guidelines, based on heterogeneous literature data derived by different populations, settings, and timeframes. Recent research focused on the inclusion of other features or questioned the clinical relev...

ea0081oc3.4 | Oral Communications 3: Thyroid 1 | ECE2022

Effect of age on efficacy and safety of cabozantinib vs placebo in patients with radioiodine refractory (RAI-R)-differentiated thyroid cancer (DTC) with progression after VEGFR-targeted therapy: subgroup analysis from Phase 3 COSMIC 311 study

Durante Cosimo , Robinson Bruce , Sherman Steven I , Krajewska Jolanta , Lin Chia-Chi , Vaisman Fernanda , Hoff Ana O , Hitre Erika , Bowles Daniel W , Hernando Jorge , Banerjee Kamalika , Levytskyy Roman M , Oliver Jennifer W , Keam Bhumsuk , Capdevila Jaume , Brose Marcia

Background: Increasing age is associated with poorer survival in DTC [Oyer SL, 2012]. In the phase 3 COSMIC-311 trial (NCT03690388), cabozantinib, an inhibitor of VEGFR2, MET, AXL and RET, significantly improved the progression-free survival (PFS) vs placebo in previously treated patients with RAI-R DTC (HR 0.22, 96% CI 0.13-0.36; P<0.0001; median follow-up 6.2 months). The impact of age on efficacy and safety was included in the prespecified subgroup analysis.</p...

ea0081oc3.5 | Oral Communications 3: Thyroid 1 | ECE2022

Functional analysis of exosomal miRNAs secreted by thyroid cancer cells

Verrienti Antonella , Maggisano Valentina , Capriglione Fancesca , Sponziello Marialuisa , Pecce Valeria , Durante Cosimo , Celano Marilena , Bulotta Stefania , Russo Diego

Background: MiRNAs transported by exosomes play a role in various processes of tumorigenesis and tumor progression. They can function as oncogenes able to structurally and biologically change the tumor microenvironment (TME) therefore playing a crucial role in cell-to-cell communication during tumor development and allowing cancer cells to become invasive and disseminate from the primary site to distant locations.We aimed to identify the exosome miRNAs that may be involved in ...

ea0081oc3.6 | Oral Communications 3: Thyroid 1 | ECE2022

RET Fusion Genes in Thyroid Carcinomas

Pekova Barbora , Sykorova Vlasta , Mastnikova Karolina , Vaclavikova Eliska , Moravcova Jitka , Vlcek Petr , Lastuvka Petr , Katra Rami , Bavor Petr , Kodetova Daniela , Chovanec Martin , Drozenova Jana , Astl Jaromir , Hrabal Petr , Vcelak Josef , Bendlova Bela

Objective: RET fusion genes are known driver mutation in thyroid cancer and have been described mainly in pediatric thyroid carcinomas, in which they represent the most common genetic alteration. In large cohorts of adult patients, RET fusions have not yet been well characterized. The aims of this study were to identify RET fusion-positive thyroid tumors in a cohort of different types of thyroid carcinomas and to correlate them with clinical and hist...