Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Oral Communications

Oral Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2

ea0081oc5.1 | Oral Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

Pdgfrα-driven Alms1 deletion in mice recapitulates the obesity and insulin resistance of Alms1 global knockout

McKay Eleanor , Luijten Ineke , McCormick Dominique , Thomson Adrian , Gray Gillian , Semple Robert

Background: Alström Syndrome (AS) is a rare autosomal recessive disease featuring highly accelerated insulin resistance, fatty liver, diabetes and heart failure among other syndromic features. Heart failure leads to significant early mortality, but is complex and likely multifactorial, with developmental defects, accelerated atherosclerosis, and fibrosis all implicated. These cardiometabolic complications occur in the face of only moderate obesity in many patients. AS is ...

ea0081oc5.2 | Oral Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

Once-weekly semaglutide delays a late phase gastric emptying of solid meal measured by repeated scintigraphic imaging in obese women with PCOS

Jensterle Mojca , Ferjan Simona , Lezaic Luka , Socan Aljaz , Zaletel Katja , Janez Andrej

Background: GLP-1 agonism have the potential to affect gastric emptying (GE), yet the reports for subcutaneous semaglutide, currently the most effective GLP-1 RA approved for weight management, remain inconclusive. It has been demonstrated that semaglutide either had no effect on GE or it delayed GE only within the first hour, without late phase retention. Notably, those conclusions were made by an indirect method of estimation of GE through ingestion, absorption and determina...

ea0081oc5.3 | Oral Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

Weight loss attempts and weight perception in women with polycystic ovary syndrome (PCOS) - a 15-year follow-up in a population-based cohort study

Pesonen Emilia , Ollila Meri-Maija , Morin-Papunen Laure , Tapanainen Juha S , Jamsa Timo , Korpelainen Raija , Niemela Maisa , Nurkkala Marjukka , Piltonen Terhi T

Background: Women with polycystic ovary syndrome (PCOS) experience increased weight gain during life, thus weight management and preventing weight gain should be the first line treatment. Weight loss is usually self-initiated because practical support for weight management is often limited or even lacking. Perception of overweight is considered an important prerequisite for weight loss attempts, although there is no prior research regarding women with PCOS. The main aim of the...

ea0081oc5.4 | Oral Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

Body composition during childhood, adolescence and adulthood influences the odds of developing polycystic ovary syndrome: a mendelian randomisation study with a systematic review and meta-analysis

Dobbie Laurence J , Zhao Sizheng Steven , Pittam Bradley , Alam Uazman , Barber Thomas M , Cuthbertson Daniel J

Background: Observational and genetic Mendelian randomisation (MR) data has demonstrated the association of adulthood overweight/obesity with development of polycystic ovary syndrome (PCOS). However, the contribution of early life (i.e. childhood/adolescence) body composition on incident PCOS is unclear. This study determines the influence of body composition on the likelihood of developing PCOS.Methods: We conducted a 2-sample Mendelian randomisation st...

ea0081oc5.5 | Oral Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

The glucocorticoid transporter ATP-binding cassette subfamily C member 1 (ABCC1) influences adiposity, glucose homeostasis and insulin sensitivity in male mice

Villalobos Elisa , Miguelez-Crespo Allende , Morgan Ruth A , Andrew Ruth , Nixon Mark , Walker Brian R

Background: Glucocorticoids (GCs) modulate glucose homeostasis by acting on metabolic tissues including liver, adipose and skeletal muscle. GC access to corticosteroid receptors in these tissues is regulated e.g. by pre-receptor metabolism. We recently identified a role for ABCC1, a transmembrane ‘drug-resistance’ transporter, as a GC exporter which limits intracellular GC concentrations and action in adipose tissue. Here, we tested the hypothesis that ABCC1, which i...

ea0081oc5.6 | Oral Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

Fetal sex predicts perinatal outcomes in women with gestational diabetes

Cidade-Rodrigues Catarina , Chaves Catarina , Melo Anabela , Figueiredo Odete , Morgado Ana , Almeida M Ceu , Martinho Mariana , Almeida Margarida , Cunha Filipe M

Introduction: Gestational diabetes (GD) is a known risk factor for delivery, fetal and perinatal complications. Fetal male sex is known to be associated with worse perinatal outcomes, such as macrosomia, neonatal hypoglycemia, low Apgar scores, birth defects and mortality. However, studies evaluating the impact of fetal sex on perinatal outcomes in women with GD are scarce. Objectives: We aimed to study whether male newborn sex is associated with neonata...