Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Poster Presentations

Diabetes, Obesity, Metabolism and Nutrition

ea0081p53 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The investigation of serum and saliva phoenixin levels in patients with type 2 diabetes mellitus

Burak Oz Muhammed , Ugur Kader , Dila Oz Zeynep , Fazıl Akkoc Ramazan , Aydin Suleyman

Purpose: Diabetes is one of the most common metabolic disease which has got many peptide hormones have in its etiology. Phoenixin (PNX), a recently discovered neuropeptide appears to have a role in energy management and metabolism through regulating insulin neogenesis and secretion, according to research. There is no research has been studied on the association between diabetes and PNX levels. The aim of the study was to see if there was a relation between PNX levels in the se...

ea0081p54 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Glucose prediction model based on continuous glucose monitoring in patients with type 1 diabetes mellitus: GlucoseML study preliminary results

Christou Maria , Katsarou Daphne N. , Georga Eleni I. , Zisidis Christos , Siolos Athanasios , Papaloukas Costas , Tigas Stelios , Fotiadis Dimitrios I.

Introduction: Current guidelines emphasize the important role of Continuous Glucose Monitoring (CGM) for type 1 diabetes mellitus (T1DM) management. The aim of the GlucoseML study is the development of a mobile health system for T1DM self-management based on CGM data, physical activity, food intake and insulin dosage. We herein present the development and evaluation of a univariate Autoregressive Moving Average (ARMA) prediction model of interstitial glucose concentration for ...

ea0081p55 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of undiagnosed depression in patients with type 2 diabetes in central India

Saboo Bharat , Saboo Shweta

Introduction: Type 2 Diabetes Mellitus (T2DM) is the most common type of diabetes in adults, People with Diabetes usually have depression which is many times undiagnosed. Significant data suggest that depression in the context of diabetes is related to a variety of negative outcomes, including poor treatment adherence, decreased quality of life, deranged blood sugar values and HbA1c levels, and increased health costs.Method: 40 patients who consented to ...

ea0081p56 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

“Correlation of biomarkers of early diagnosis of diabetic retinopathy”

Bakhritdinova Fazilyat , Urmanova Firuza , Kengilbaeva Guzal

The purpose of the study is to assess the relationship of the level of growth factor level (VEGF) in blood serum with retinal microcirculation indicators according to oct-A data in patients with type 2 diabetes mellitus (DM2), with different stages of diabetic retinopathy (DR).Material and research methods: 252 people were examined (n=504), of which 168 patients with type 2 type and 84 practically healthy persons. The main group...

ea0081p57 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diagnosis of gestational diabetes mellitus in the COVID-19 pandemic: comparative analysis of women with positive O’Sullivan test in the same trimester of 2019 and 2020

Ignacio Martinez Montoro Jose , Jose Simon Frapolli Victor , Molina Vega Maria , Espina Sonsoles Morcillo , Suarez Arana Maria , Tinahones Francisco J. , Jose Maria , Cesar Picon

Introduction: In May 2020, during the COVID-19 pandemic, the Spanish Group of Diabetes and Pregnancy published a consensus document establishing the alternative diagnostic criteria for gestational diabetes mellitus (GDM) in case of impossibility to perform the two-step traditional approach due to the COVID-19 sanitary emergency. This study aims to compare different characteristics of pregnant women who tested positive in the O’Sullivan test in the same pregnancy trimester...

ea0081p58 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Study of change in physical activity behavior of diabetic patients after regular awareness sessions by primary care physicians

Inamdar Aniket

Background: Humans have been increasingly spending more time in sedentary behaviors such as prolonged sitting. Regular physical activity is associated with enhanced physical and mental health. Studies have shown that regular physical activity reduces the risk of cardiovascular diseases, diabetes mellitus, osteoporosis, depression and obesity. Patients frequently identify their family physicians as an important source of constant encouragement for physical activity.<p class...

ea0081p59 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impaired glucose homeostasis in a tau knock-in mouse model

Benderradji Hamza , Kraiem Sarra , Emilie Courty , Eddarkaoui Sabiha , Cyril Bourouh , Emilie Faivre , Laure Rolland , Emilie Caron , Melanie Besegher , Frederik Oger , Theo Boschetti , Kevin Carvalho , Bryan Thiroux , Thibaut Gauvrit , Emilie Nicolas , Victoria Gomez-Murcia , Anna Bogdanova , Antonino Bongiovanni , Anne Tailleux , Steve Lancel , Kadiombo Bantubungi , Nicolas Sergeant , Jean-Sebastien Annicotte , Luc Buee , Didier Vieau , David Blum , Valerie Buee-Scherrer

Introduction: Alzheimer disease (AD) is the leading cause of dementia. While impaired glucose homeostasis has been shown to increase AD risk and pathological loss of tau function, the latter has been suggested to contribute to the emergence of the glucose homeostasis alterations observed in AD patients. However, the links between tau impairments and glucose homeostasis, remains unclear.Objective: In order to better understand the links between tau and gl...

ea0081p60 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Performance of EKFC, FAS and 2021 CKD-EPI equations for estimating glomerular filtration rate in people with type 2 diabetes

Martins Rocha Bruna , Escott Gustavo Monteiro , Fagundes Silva Luiza Carolina , Franciele Porgere Indianara , Tochetto Luis Afonso , de Almeida Brondani Leticia , Silveiro Sandra Pinho

Background: Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD) worldwide. In clinical practice, kidney function is routinely assessed through glomerular filtration rate (GFR) estimated by equations. However, the accuracy of current equations has been questioned for people with diabetes mellitus (DM).Aim: To evaluate the performance of the European Kidney Function Consortium (EKFC), the Full Age Spectrum (FAS) and the 2021 Chronic...

ea0081p61 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Single nucleotide polymorphism in the ADIPOQ gene modifies adiponectin levels and glycemic control in type two diabetes mellitus patients

Al Bashir Samir , Alfaqih Mahmoud A. , Alorjani Mohammed

Diabetes Mellitus (DM) is the ninth leading cause of death worldwide. Mortality from DM is largely attributed to disease complications. Glycemic control of DM patients reduces mortality. Studies indicated that the lack of glycemic control in DM patients could be influenced by the genetic background of the patients. Evidence suggests that adiponectin levels are dysregulated in DM patients with poor glycemic control. Serum adiponectin level is a heritable trait influenced by sin...

ea0081p62 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The link between type of antidiabetic agents and COVID 19 severity in patients with pre-existing type 2 diabetes

Risovic Ivona , Djekic Danijel , Stanic Anja

Introduction: Type 2 diabetes is one of the main risk factors for severe COVID 19 infection. Inadequate glycemic control is related to high inflammation, hypercoagulability, and mortality in COVID-19 patients. Glucose lowering medications commonly used to treat diabetes mellitus (DM) might have effects on COVID 19 pathogenesis. Overall, evidence is conflicting as to which glucose-lowering drugs are associated with the most favourable outcomes in patients with COVID-19. The aim...

ea0081p63 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Exceptional genetic transmission of a ABCC8 mutation in two cases of diffuse hyperinsulinism in a dichorionic diamniotic (DCDA) twin pregnancy

Telehuz Daniela , Oana Plesa , Florence Bouilloud , Adela Voican , Isabela Banu , Jean-Baptiste Arnoux , Helene Wucher , Olivier Dupuy

We present the case of a 36-year-old female with a focal neonatal hyperinsulinism diagnosed at birth in a context of hypoglycemia that was resistant to Diazoxide treatment. A subtotal pancreatectomy was performed and histology showed a focal hyperinsulinism. The mutation of ABCC8 was not searched at this point. The patient developed an insulin dependent diabetes at the age of 9 and required an insulin pump. In 2017 the patient was planning a pregnancy so she consulted a geneti...

ea0081p64 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The bidirectional relationship between testosterone and metabolic disorders: testosterone deficiency as an early marker of cardiovascular risk in young men

Menafra Davide , De Angelis Cristina , Garifalos Francesco , Castoro Michele , Verde Nunzia , Piscopo Mariangela , Galdiero Giacomo , Pivonello Claudia , Simona Auriemma Renata , Chiodini Paolo , Colao Annamaria , Pivonello Rosario

In the last years an increasing incidence of cardiovascular diseases (CVD) has been reported in young adults (18-45 yrs), probably accounted by the significant increase in CV risk (CVR) factors. Observational and interventional studies, mainly focused on middle-aged and elderly men, demonstrated that metabolic CVR (mCVR) factors and CVD manifestations are common in hypogonadal men and, conversely, testosterone deficiency is highly prevalent in metabolic disorders; the lack of ...

ea0081p65 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hypoglycaemia associated with variable rate intravenous insulin infusion and concurrent administration of balanced electrolyte solution: A single hospital experience

Shah Vinit , Jasionowska Sara , Kelly Sarah , Joseph Reshma , Amran Maisarah

Background: Variable rate intravenous insulin infusion (VRIII) or ‘sliding scale’ is required for certain patients with diabetes to keep their blood glucose within the recommended target range during an acute illness or a period of starvation. When used in the right context this has shown to improve outcomes but can also lead to morbidity especially hypoglycaemia.Aim: Evaluate risk of hypoglycaemia in patients on VRIII with concurrent use of ba...

ea0081p66 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The role of empagliflozin in palmitate-induced ER stress and apoptosis in H9C2 cells

Jeong Jae Yeop , Choi Sung-E , Song Min Woo , Ho Park Suck , Kang Yup , Ho Kim Tae , Ahn So-Yeon , Jin Kim Hae , jin Han Seung , Jeon Ja Young , Lee Nami , Jung Kim Dae , Lee Kwan-Woo

Aim/hypotheses: Ectopic lipid accumulation in the heart contributes to the abnormal function of the heart and to the death of cardiomyocytes. Saturated FFA is one of the most important causes of death in cardiomyocytes. Although empagliflozin has been reported to be beneficial for people with diabetic complications and/or CVD, it has not been confirmed as to how it affects cardiomyocytes death by FFA. This study was designed to evaluate the protective effects of SGLT2 inhibito...

ea0081p67 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Leptin increases VLDL triglyceride secretion and reduces hepatic lipid content in lean male subjects

Metz Matthaeus , Beghini Marianna , Pfleger Lorenz , Wolf Peter , Bastian Magdalena , Harreiter Jurgen , Baumgartner-Parzer Sabina , Marculescu Rodrig , Krebs Michael , Hackl Martina , Trauner Michael , Krssak Martin , Stangl Herbert , Kautzky-Willer Alexandra , Furnsinn Clemens , Scherer Thomas

Background: Leptin reduces hepatic lipid content in lipodystrophic and overweight, relatively hypoleptinemic NAFLD patients. However, the underlying mechanism is unknown. In rodents, the anti-steatotic action of leptin is mediated by an increase in VLDL secretion and depends on an intact vagal innervation of the liver.Methods: In this randomized, placebo-controlled, crossover trial, we study the effects of a single metreleptin injection (0.1 mg/kg body w...

ea0081p68 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Development and validation of a new gestational diabetes mellitus (gdm) risk algorithm

Mendizabal Leire , Arregui Maddi , Valerio Johanna , Ramos Ana Maria , Barabash Ana , de la Torre Nuria Garcia , zulueta mirella , Arana Eunate , Saez Eva , Aranbarri Igotz , Martinez-Lage Juan , Cortazar Alicia , Gaztambide Sonia , Castano Luis , Simon Laureano , Luis Calle-Pascual Alfonso

Background and Objective: Gestational Diabetes Mellitus (GDM) is associated with life-long adverse outcomes for the mother and the baby. To date there is no rigorous clinical test for the assessment of GDM risk, since estimation of GDM risk is currently primarily based on clinical risk factors. Additional markers are needed to identify women at high risk. Our aim was to develop and validate a risk assessment model to identify women at high risk of GDM through an algorithm that...

ea0081p69 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evaluating a novel virtual simulation tool for clinical training to improve clinician confidence managing cases in diabetes and endocrinology

Chen Wentin , Ponniah Gobeka , Hebbar Meghnaa , Sheikh Jameela , Zhou Dengyi , Malhotra Kashish , Evans Nia , Warmington Emily , Ali Anisah , Rezai Fatema , Allison Isabel , Cuen Pan Carina Synn , Nirmal Rachel , Sakthivel Pavithra , Soran Vina , Abdi Zakee , Kaur Harjeet , Delson Dwi , Piya Simran , Melson Eka , Davitadze Meri , Kempegowda Punith , Simulation Simba

Introduction: The delivery of medical education has transformed from in-person to remote teaching, accelerated by the ongoing COVID-19 pandemic. Simulation is a useful teaching modality increasingly used to develop healthcare professionals’ knowledge and skills while protecting patients from unnecessary risks. Although simulation has traditionally occurred face-to-face, many of its principles can be adapted for remote teaching. Simulation via Instant Messaging – Birm...

ea0081p70 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Cause of Death for Patients with Diabetes Mellitus in Korea: Multicenter study

Moon Hyeyeon , Park Mi Kyoung , Suh Sunghwan

Background: In Republic of Korea, prevalence of type 2 diabetes mellitus (T2DM) has increased substantially in recent decades, but there are no reliable estimates of the excess mortality currently associated with diabetes.Methods: We analyzed all subjects were T2DM patients over the age of 30 whose death certificates were issued at three hospitals in the Busan metropolitan area from 2010 to 2014. The causes of death were retrospectively determined based ...

ea0081p71 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The neural mechanism of selective activation of kisspeptin neurons in the ARC of the hypothalamus regulate bown adipose thermogenesis in female mice

Liu Qinyu , Li Qian , Lin Xiaofeng , Xu Xieyu , Chen Gang , Wen Junping

Objectives: Overweight and obesity currently burden our public health, and especially with the aging process in the world, the incidence of obesity is significantly higher in women than that in men partly. Recent studies reported that hypothalamic kisspeptin neurons, with obvious changes of number and structure in female during life, play a crucial role in the regulation of central energy homeostasis. But the precise mechanism remains an enigma.Methods: ...

ea0081p72 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Clinical and nutritional risk factors for insulin requirement during gestational diabetes mellitus

Khalaf Rahma , Htira Yosra , Hadj Ali Zohra , Jemai Chaima , Hedfi Imen , Mami Faika Ben

Background and aim: Gestational Diabetes Mellitus (GDM) is the commonest medical pregnancy complication. Nutritional interventions come to the fore as one of the few levers for managing GDM, as many medications are either harmful to the growing fetus, or their toxicity is uncertain. The aim of this study was to assess the potential clinical features and nutritional risk factors of insulin treatment during GDM.Methods: This was a prospective study includ...

ea0081p73 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Different treatment outcomes (acute dietary restriction vs conventional treatment) in women with new-onset type 2 diabetes (T2DM), with previous gestational diabetes (GDM)

Asatiani Natalia , Kurashvili Ramaz , Inashvili Ekaterine , Shelestova Elena , Dundua Mzia

Some literary data demonstrate that the twin defect of beta-cell failure and insulin resistance that underline T2DM can be reversed by acute negative energy balance alone. The aim of the present work was to assess treatment outcomes in women with new onset T2DM, who were previously diagnosed with GDM treated with acute dietary restriction or conventionally at 32 weeks postpartum (PP).Methods: In total 174 women with T2DM at 32 weeks PP, were enrolled in ...

ea0081p74 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence and predictive factors of factitious hypoglycemia in non-diabetic patients

Terzi Amani , Oueslati Ibtissem , Yazidi Meriem , Kamoun Elyes , Chihaoui Melika

Introduction: Spontaneous hypoglycemia in non-diabetic patients is a rare metabolic emergency caused by multiple etiologies. Factitious hypoglycemia, a form of the Munchausen syndrome, is defined as the surreptitious use of insulin or oral hypoglycemic agents to deliberately induce self-harm. It is one of the most challenging diagnoses associated with significant morbidity and mortality. The aim of this study was to assess the prevalence and the associated factors of factitiou...

ea0081p75 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Type 1 diabetes technology and quality of life: glucose control and beyond

Irina Briganti Silvia , Maggi Daria , Strollo Rocky , Kyanvash Shadi , Lanza Oreste , Pozzilli Paolo , Manfrini Silvia

Background: Technological advances in continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) should aim to improve glucose control and quality of life in patients diagnosed type 1 diabetes (T1D).Aim: The aim of our study was to compare different CGM and CSII devices on these targets.Methods: Sixty-nine T1D patients (mean age 39±12; 31 males) were recruited. 36 were on multiple daily insulin inj...

ea0081p76 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Glucagon-like peptide-1 analogues: a new way to quit smoking? SKIP – a randomised controlled study

Lengsfeld Sophia , Burkard Thilo , Meienberg Andrea , Jeanloz Nica , Vukajlovic Tanja , Bologna Katja , Steinmetz Michelle , Sailer Clara , Coynel David , Vogt Deborah R , Hemkens Lars G. , Speich Benjamin , Kuhne Jill , Baur Fabienne , Lutz Linda , Bathelt Cemile , Zanchi Davide , Christ-Crain Mirjam , Winzeler Bettina

Background: Cigarette smoking is the leading preventable cause of premature death. Smoking cessation is one of the central goals in medicine, but despite dedicated programs, quit rates remain low due to barriers such as nicotine withdrawal syndrome or post-cessation weight gain. Glucagon-like peptide-1 (GLP-1) analogues reduce energy intake and body weight and seem to modulate addictive behavior. These GLP-1 properties are of major interest in the context of smoking cessation....

ea0081p77 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Comparison of hyperphagia and problem behaviors in participants with prader-willi syndrome (PWS) receiving diazoxide choline extended-release (DCCR) with matched participants in PATH for PWS (PfPWS)

Gevers Evelien , Strong Theresa , Miller Jennifer , Felner Eric , Goldstone Tony , Bridges Nicola , Yanovski Jack , Bird Lynne , Butler Merlin , Obrynba Kathryn , Lah Melissa , Shoemaker Ashley , Mejia-Corletto Jorge , Stevenson David , Wilding John , Kimonis Virginia , Abuzzahab Jennifer , Konczal Laura , Mathew Verghese , Cowen Neil , Woloschak Michael , Bhatnagar Anish

Background: PWS is a rare neurodevelopmental genetic disorder characterized by hyperphagia, obesity, hormonal deficiencies, and problem behaviors for which there are no approved treatment. DCCR administration (100-525 mg/day) up to 52 weeks in participants with PWS improved hyperphagia, behavior, body composition and metabolic markers.Objective: The objective of this study was to compare changes in hyperphagia (using Hyperphagia Questionnaire for Clinica...

ea0081p78 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Habit-intervention induces an amelioration of prediabetics cardiometabolic traits by lowering the miR-21/ROS/HNE damaging axis

La Sala Lucia , Tagliabue Elena , Mrakic-Sposta Simona , Senesi Pamela , Terruzzi Ileana , Luzi Livio , Trabucchi Emilio

The prevalence of prediabetes is increasing in the global population and its metabolic derangements may expose to a higher risk to develop type 2 diabetes (T2D) and its cardiovascular burden. Lifestyle modifications might have considerable benefits on ameliorating metabolic status. In light of this scenario, preventive programmes are focusing on the modification of lifestyle that notoriously decreases the incidence of T2D, to reduce the risk and delay T2D and its burden: Diabe...

ea0081p79 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Non-invasive quantification of pancreatic islet beta-cell function in people with type 1 diabetes mellitus

Joshi Shruti , Singh Trisha , Kershaw Lucy , Gibb Fraser , Dweck Marc R , Williams Michelle , Semple Scott , Forbes Shareen , Reynolds Rebecca , Newby David

Background and Aims: Type 1 diabetes mellitus (T1DM) is characterised by autoimmune destruction of pancreatic beta-cells resulting in insulin deficiency. Evaluation of novel therapies for T1DM requires reliable methods to measure beta-cell function, which is unattainable using traditional non-invasive imaging techniques. A new approach is manganese-enhanced magnetic resonance imaging (MEMRI). As a calcium analogue, manganese is taken up into pancreatic beta-cells during insuli...

ea0081p80 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The COVID-19 in patients with diabetes mellitus in tashkent: a retrospective cohort study

Alieva Anna , Djalilov Abdulaziz , Khaydarova Feruza , Alimov Anvar , Khalilova Dilovar , Alimova Nasiba , Tajieva Iroda , Talenova Vasila

Background: Since the very first outbreak, scientists have been trying to determine the most critical pathogenetic mechanisms for the development of COVID-19 and related complications, analyze individual subpopulations of patients with chronic diseases and develop optimal tactics to combat not only the infection itself but also its acute and chronic complications.Aim: to identify and analyze factors influencing the severity of the COVID-19 course among p...

ea0081p81 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Adipocytokines profile in patients with Graves’ orbitopathy and the effect of high-dose corticosteroids

Schovanek Jan , Krupka Michal , Cibickova Lubica , Karasek David

Graves’ orbitopathy (GO) is a serious, progressive eye condition seen in patients with autoimmune thyroid disease. GO is characterized by inflammation and swelling of soft orbital tissues. Adipose tissue produces cytokine mediators called adipokines. The present study focuses on the relationship between serum levels of selected adipokines in patients with GO, comparing them with the control group, and uniquely describes the effect of high-dose systemic corticosteroids (HD...

ea0081p82 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Irisin in pediatric patients with Prader Willi Syndrome: the role of body composition and glucose metabolism

Mai Stefania , Fintini Danilo , Mele Chiara , Convertino Alessio , Bocchini Sarah , Grugni Graziano , Aimaretti Gianluca , Vietti Roberta , Scacchi Massimo , Crino Antonino , Marzullo Paolo

Irisin is a myokine involved in the browning of white adipose tissue and in the regulation of energy expenditure, glucose tolerance and insulin sensitivity. It was previously demonstrated that obese adults with Prader-Willi syndrome (PWS) harbor lower irisin levels than individuals with common obesity. Significant associations seem to relate irisin to muscle mass, REE, insulin resistance and triglycerides and also the strongest independent predictors of irisin levels were PWS ...

ea0081p83 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Menstrual cycle abnormalities as distinctive sign of type 1 diabetes mellitus: results from a meta-analysis

Corleto Rossella , Greco Carla , Cacciani Marta , Spaggiari Giorgia , Simoni Manuela , Santi Daniele

Background: Type 1 diabetes mellitus (T1DM) management profoundly changed across years, with increasing emphasis on stringent glycaemic control. While it is well demonstrated that the progressive improvement of glycaemic control allows a tighter command of diabetes-related complications, the positive implications thereof on reproductive functions are still unclear. Indeed, it is well known that oligomenorrhea and amenorrhea are more frequently detected in young women with T1DM...

ea0081p84 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Vitamin D supplementation lowers the serum levels of branched chain amino acids in a cohort of patients with type two diabetes mellitus

Alfaqih Mahmoud A. , Al Bashir Samir , Melhem Nebras

Background: Type two Diabetes Mellitus (T2DM) is a rapidly growing crisis. Data from several T2DM cohorts demonstrate that elevated levels of serum branched chain amino acids (BCAAs) increase the risk of the disease. BCAAs levels correlate with parameters that reflect glycemic control. Elevated levels of BCAAs in T2DM is associated with a higher risk of complications. Vitamin D plays an important role in regulating insulin action on target tissues. Normalization of serum vitam...

ea0081p85 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Ramadan fasting without the doctor’s consent: which patient, and what impact? Results of a prospective study

Halouache Ali , Yassine Errahali , Sanae Chakdoufi , Jad Isouani , Anas Guerboub

Background and aims: The objective of our study is to evaluate the respect of Muslim diabetics for the contraindication of fasting and the control metabolic impact of fasting during the month of Ramadan. Materials and methods: This analytical cross-sectional study was conducted during the period from Mars to June of the year 2021, within the department of endocrinology and metabolic diseases of the Military Hospital of Instruction Moham...

ea0081p86 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of an extract of the Andean plant Lampaya on insulin signaling and proinflammatory markers in human adipocytes treated with palmitic acid

Ormazabal Paulina , Yuri Gabriela , Villagran Isidora , Cerda Alexis , Cifuentes Mariana , Paredes Adrian , Morales Glauco

Background: Obesity is strongly associated with a state of chronic low grade systemic inflammation and insulin resistance (IR). IR at the molecular level may be defined as a diminished activation of the metabolic phosphatidylinositol-3-kinase (PI3K)/Akt pathway of insulin. On the other hand, inflammatory response may be activated by NF-κB. Subject with obesity have elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin and infl...

ea0081p87 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

COVID-19 and Steroids- How well are we monitoring blood glucose levels?

Me-Me-Ko Aye , Kapoor Ashutosh , Riaz Fatima , Wightman Stuart , Rao-Balakrishna Prasanna

Background: The Covid-19 pandemic has led to various unprecedented challenges and obstacles, especially in the field of Diabetes and Metabolism, many of which are as novel as the pandemic itself. Discovering efficacious therapeutic options resulting in positive outcomes has been a challenge. Dexamethasone has been shown to reduce mortality in patients with Covid-19 pneumonitis who require oxygen therapy and/or ventilation. Exogenous steroid therapy is renowned to cause adverse...

ea0081p88 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Sodium glucose cotransporter 2 inhibitors treatment in acromegalic patients with diabetes

Zaina Adnan , Grober Yuval , Abid Ali , Arad Eldad , Golden Elena , Badarny Samih

Introduction: Acromegaly is a chronic disease generally caused by a GH-secreting pituitary adenoma. GH excess causes insulin resistance and impair β cell function, predisposing patients with acromegaly to develop DM. Treatment of diabetes has been revolutionized since the introduction of sodium-glucose cotransporter inhibitors (SGLT2i). This novel class is widely used in type 2 diabetes mellitus (T2DM) and recently was approved for patients with heart failure with reduced...

ea0081p89 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Predictors of persistant abnormal glucose tolerance in post partum in women with gestational diabetes mellitus

Khalaf Rahma , Htira Yosra , Hadj Ali Zohra , Jemai Chaima , Hedfi Imen , Mami Faika Ben

Background and aim : To determine clinical and metabolic predictors of persistant abnormal glucose tolerance in post partum after gestational diabetes mellitus (GDM). Methods: This was a prospective study including 150 patients with GDM who underwent 75g oral glucose tolerance test (OGTT) at 4-12 weeks after delivery. Results: The prevalence of abnormal glucose tolerance in post partum after GDM was 32,8 % ,...

ea0081p90 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evening chronotype is associated with hormonal and metabolic disorders in Polycystic Ovary Syndrome

Verde Ludovica , Barrea Luigi , Vetrani Claudia , Docimo Annamaria , De Alteriis Giulia , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna

Objective: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder. Recently in the context of obesity, which often coexists with PCOS, it has been highlighted the role of chronotype as risk factor for obesity-related cardiometabolic complications. Given the importance of chronotype categories in the context of metabolic diseases and being PCOS characterized by metabolic derangements, we aimed to investigate the prevalence of chronotype categories in wome...

ea0081p91 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

PCSK-9 inhibitors and the reduction of serum lipoprotein (a) levels: experience of the reference center

Leskovar Dunja , Perica Drazen , Sucur Nediljko , Hauptman Ana Godan , Pećin Ivan

Introduction: PCSK-9 (proprotein convertase subtilisin/kexin type 9) inhibitors are monoclonal antibodies that affect metabolism of low-density lipoprotein (LDL) by binding to the LDL receptor and promoting lysosomal degradation. There are two pcsk-9 inhibitors currently available: alirocumab (Praulent) and evolocumab (Repatha) which are administered subcutaneously every 14 days. Two large randomized studies (FOURIER, ODYSSEY) have shown that pcsk-9 inhibitors reduce LDL-chole...

ea0081p92 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Transforming growth factor beta 1: a new factor reducing hepatic sex hormone binding globulin production during liver fibrosis development

Brianso Llort Laura , Fuertes Rioja Lidia , Ramos Perez Lorena , Salcedo Allende Maria Teresa , Hernandez Cristina , Canonge Rafael Simo , Martinez David

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represent a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different non-alcoholic fatty liver disease (NAFLD) mouse models and that SHBG plays an active role in the development of this disease. In the present work, we are interes...

ea0081p93 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Determination of serum and cord blood vitamin D status in women in twin pregnancies using liquid chromatography-tandem mass spectrometry – a preliminary results

Zgliczynska Magdalena , Szymusik Iwona , Kowalski Konrad , Ostrowska Magdalena , Kosinska-Kaczynska Katarzyna

Objective: Vitamin D has a pleiotropic effect on the human body. Besides its classical function as a regulator of calcium and phosphorus metabolism, it influences the secretion of other hormones, modulates the immune response and regulates cell proliferation and differentiation. Because women in twin pregnancies have higher metabolic needs, it can be expected that they might have higher risk of vitamin D deficiency.Aim of the study and method: The aim is...

ea0081p94 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The prevalence of non alcoholic fatty liver disease among diabetic patients attending the diabetic clinic in a tertiary care institute in colombo

Ranathunga Ishara , Naveenkumar J P , Athukorala T G , Sumanatilleke Manilka , Somasundaram Noel

Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is the presence of hepatic steatosis in the absence of other causes for secondary hepatic fat accumulation. The incidence and the prevalence of the NAFLD has risen exponentially in the recent past especially in the patients with diabetes. We have studied the prevalence of NAFLD in patients with diabetes attending the diabetes clinic based on the biochemical and ultrasonic criteria, the risk factors for diseas...

ea0081p95 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Perceived stigma in type 2 diabetes patients

Achwak Mehrez , Lassoued Najoua , Mohsen Selma , Chedly Khalil , Majdoub Marwa , Boubaker Fedya , Zantour Baha , Alaya Wafa , Sfar Habib

Introduction: Diabetes stigma (DS) refers to the experience of negative feelings such as exclusion, blame, rejection, or judgment due to having a chronic disease. The objective of this work was to measure the DS and its clinical determinants in type 2 diabetic patients.Patients and methods: Cross-sectional study conducted on 84 type 2 diabetic patients who consulted on an outpatient basis between September and December 2021. DS was assessed using the ara...

ea0081p96 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Increased haematocrit mediates lowering of blood glucose in mice exposed to hypoxia or treated with erythropoetin

Scherer Thomas , Metz Matthaeus , Beghini Marianna , Durr Sabine , Corina Luca Andreea , Kaplanian Mairam , Abu Eid Sameer , Kautzky-Willer Alexandra , Furnsinn Clemens

Introduction: Mountain dwellers show a lower prevalence of diabetes, which among countless other factors could be due to lower partial oxygen pressure at high altitude. The present study was to investigate in an experimental setting, if and how reduced oxygen availability affects blood glucose.Methods: Male obese mice on high fat diet were continuously maintained under a normobaric hypoxic atmosphere (10% oxygen) for three months. To exclude indirect eff...

ea0081p97 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Chronotype: a tool to screen eating habits in Polycystic Ovary Syndrome?

Verde Ludovica , Barrea Luigi , Vetrani Claudia , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna

Background: Polycystic Ovary syndrome (PCOS) is the most common endocrine disorders in women of reproductive age whose lifestyle approach is an essential part of the treatment. Recently chronotype, i.e. a trait that determines individual’s circadian preference in behavioral and biological rhythms, has been reported to play a role in determining nutrition preferences and the risk of developing chronic diseases. Thus, the aim of the study was to investigate if chronotype ca...

ea0081p98 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

VLCKD: a real time safety study in obesity

Verde Ludovica , Barrea Luigi , Vetrani Claudia , Marino Francesca , Aprano Sara , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna

Very Low-Calorie Ketogenic Diet (VLCKD) is currently a promising approach for the treatment of obesity. However, little is known about the side effects since most of the studies reporting them were carried out in normal weight subjects following ketogenic diet for other purposes than obesity. Thus, the aims of the study were: 1) to investigate the safety of VLCKD in subjects with obesity; 2) if VLCKD-related side effects could have an impact on its efficacy. In this prospectiv...

ea0081p99 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A novel successful therapeutic option after a journey of treatment failures in a patient with heterozygous melanocortin-4 receptor deficiency

Welling Mila , Mohseni Mostafa , van Rossum Elisabeth

Introduction: Obesity is a complex and multifactorial disease with a chronic and relapsing nature, and is associated with over 200 co-morbidities. In a minority of patients, the obesity is caused by gene defects in the leptin-melanocortin pathway. As lifestyle interventions often fail in these patients, additional anti-obesity pharmacotherapy is needed. In this case report, we describe the therapeutic journey of a patient with early-onset obesity and hyperphagia due to heteroz...

ea0081p100 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The trigliserid-glucose index shows a stronger correlation with serum adiponectin levels than HOMA-IR

Nahit Sendur Suleyman , Isgin Atici Kubra , Turan Demirci Busra , Lay Incilay , Buyuktuncer Zehra , Erbas Tomris

Objective: Different methods are used to identify individuals with insulin resistance. The gold standard is the euglycemic-hyperinsulinemic clamp. However, in clinical practice, clamp is not preferred because it is cumbersome, the HOMA-IR index is used more often. The Trigliserid-glucose (TyG) index is a new and practical way to identify individuals with insulin resistance (IR). When compared to HOMA-IR, this index has been shown to be more reliable in determining insulin resi...

ea0081p101 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hypothyroidism and obesity in a population of Italian women with lipedema and correlation with the clinical stage

Patton Laura , Ricolfi Lorenzo

Aim: Lipedema is a painful fat disorder that affects ~11% of the female population, characterized by bilateral, disproportionate accumulation of subcutaneous adipose tissue predominantly in the lower body. The initial manifestations of lipedema arise in phases of hormonal change (puberty, pregnancy, menopause). The pathophysiology of lipedema is unclear. The putative causes proposed include altered adipogenesis, microangiopathy, and disturbed lymphatic microcirculation The dis...

ea0081p102 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Design of a phase 2, double-Blind, placebo-controlled trial of setmelanotide in patients with genetic variants in the melanocortin-4 receptor pathway

Farooqi Sadaf , Wabitsch Martin , Chung Wendy , Ohayon Olga , Scimia Cecilia , Yuan Guojun , Shah Bhavik P.

Introduction: Rare genetic causes of obesity result from disruption of the melanocortin-4 receptor (MC4R) pathway, a regulator of energy balance. Patients with obesity due to variants in multiple genes, including POMC, LEPR, SRC1, and SH2B1, have shown weight and hunger reductions after treatment with setmelanotide, an MC4R agonist. DAYBREAK is a Phase 2 trial of setmelanotide in patients with additional gene variants with suggested relevance to the...

ea0081p103 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The crosstalk between adiposity and bone: a potential role for SIRT1 and sclerostin

Tozzi Rossella , Masi Davide , Cipriani Fiammetta , Elena Spoltore Maria , Contini Savina , Watanabe Mikiko , Basciani Sabrina , Lubrano Carla , Gnessi Lucio , Mariani Stefania

Background and aim: Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. SIRT1 pharmacological induction improves bone quality both in murine and human models and- as adiposity increases – its expression decreases both in peripheral tissues and blood. Sclerostin reduces osteoblasts’ differentiation and mineralization and is associated with DMT2, obesity and cardiovascular risk. We evaluated the circulating SIRT1 and sclerostin r...

ea0081p104 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of basal bolus insulin therapy on glucose control and mortality in patients with type 2 diabetes hospitalized with COVID -19: a retrospective study

Chertok Shacham Elena , Maman Nimra , Ishay Avraham

Introduction: Previous studies have reported that SARS-CoV-2 infection is associated with a more severe disease and worse outcome in patients with diabetes mellitus. Insulin is the mainstay of diabetes therapy in the inpatient setting. However, the treatment of diabetes in patients with COVID-19 remains unclear. In this study we investigate the influence of different insulin regimens and other antidiabetic medications on glucose control and mortality in COVID-19 patients with ...

ea0081p105 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Relationship between change in glycemic parameters and body weight with IDegLira in type 2 diabetes

Risovic Ivona , Sumarac-Dumanovic Mirjana , Bojic Mirjana , Djekic Danijel

Introduction: IDegLira is the first fixed ratio combination of a basal insulin degludec and a glucagon-like peptide-receptor analogue liraglutide. These combination producereduction in glycated hemoglobin A1c (HbA1c) and help to mitigate the weight gain. The aim of this study was to evaluate relationship between change in glycemic parameters and body weight in patients who began therapy with IDegLira.Patients and Methods: Retrospective study included 86 ...

ea0081p106 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Features of the level of amylinemia in patients with latent autoimmune diabetes in adults

Tsaryk Iryna , Pashkovska Nataliia

Background: Among the heterogeneous types of diabetes mellitus (DM), latent autoimmune diabetes in adults (LADA) is the most common and attracts the attention of scientists, the pathogenesis of which combines the main mechanisms of classical type 1 (T1DM) and type 2 diabetes mellitus (T2DM). The role of hyperamylinemia in the development and progression of LADA remains out of the researchers’ attention.The objective: of the study was to determine th...

ea0081p107 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The relation between insulin resistance and both growth hormone and insulin-like growth factor (IGF-1) levels in a sample of Iraqi patients with type 2 diabetes

Mohammed Alrubyae Hasanain , Al-Saffar Araz , Allehibi Khalid

Introduction Background: Over the last decade, scientific attention has been drawn to the potential role of Growth hormone (GH) and Insulin Like Growth Factor-1 (IGF-1) in the pathogenesis and progression of T2DM. Both hormones are interrelated but exert variable effect on glucose homeostasis. While GH increases blood glucose level, IGF-1 maintain insulin secretion and enhance insulin sensitivity.Methods: A cross sectional study conducted in the National...

ea0081p108 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of autosomal dominant mutations of Familial hypercholesterolemia in Finnish patients with premature coronary artery disease and elevated LDL-C levels

Jokiniitty Antti , Eskola Markku , Saarela Tanja , Metso Saara

Background and aims: To assess the prevalence and variability of pathogenic or likely pathogenic autosomal dominant mutations (ADM) of Familial Hypercholesterolemia (FH) in a Finnish cohort of patients with premature coronary artery disease (CAD) and elevated LDL-C levels.Methods: Study population was enrolled from 162 patients diagnosed with premature CAD (men < 55 years and women < 60 years) and history of high LDL-C (≥ 5 mmol/l) levels, ...

ea0081p109 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Maternal triglyceride levels, and not fructosamine, in early pregnancy are associated with birth weight

Clinck Isabel , Verelst Faro , Twickler Marcel , Vrijkotte Tanja

Objectives: Maternal metabolism has a major impact on foetal growth, and the risk of developing obesity, cardiovascular disease and diabetes in later life. Identification of maternal metabolic parameters in early pregnancy that predict birth weight (BW), is pivotal in the prevention of these diseases. We evaluated whether maternal triglyceride (TG) or fructosamine levels in early pregnancy, as possible reflectors of maternal insulin resistance (IR), could predominantly contrib...

ea0081p110 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evaluation of a new transition organization for young adults with endocrine or metabolic diseases

Le Roux Enora , Touraine Philippe

Objective: To evaluate the effect of a new care organisation on multiple outcomes of transition success and its cost-effectiveness in patients with any endocrine or metabolic disease diagnosed during childhood and transferred to adult care.Design: Non-randomized controlled trial in a French University Hospital.Methods: Patients transferred to adult care during the control period (04/2014-08/2016) and the intervention period (09/201...

ea0081p111 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Analysis of the nutritional status of women in twin pregnancies in terms of key vitamins and microelements – preliminary results

Zgliczynska Magdalena , Szymusik Iwona , Ostrowska Magdalena , Kosinska-Kaczynska Katarzyna

Objective: Diet and nutritional status during pregnancy are critical for the health of both mothers and the neonates. Women in twin pregnancies have higher metabolic needs compared to women in single pregnancies and it can be expected that they have higher risk of key vitamins and micronutrients deficiencies. However, very scarce data are currently available on this topic.Aim of the study and method: The main aim is to analyze the nutritional status of w...

ea0081p112 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Expression of beta2 adrenergic receptors in pancreatic islets of metabolic syndrome induced C57BL/6J Mice

Gangadhara Vijayalakshmi , Abraham Asha

Background: The global prevalence of metabolic syndrome (MetS) characterized by type 2 Diabetes (T2D), obesity, and cardiovascular diseases, has reached alarming proportions worldwide. The prevalence is rapidly increasing among all the age groups due to calorie dense food intake and sedentary lifestyle. Beta adrenergic receptors (β ADRs), are known for its role in thermogenesis, lipolysis and glucose metabolism. Ceasrine et al., 2018, reported that pancreas-speci...

ea0081p113 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of hyperuricemia at metabolic syndrome and diabetic nephropathy, among patients with diabetes mellitus

Nelaj Ergita , Gozhita Sonila , Kecaj Irida , Gjermeni Ilir , Tase Mihal

Hyperuricemia is a high risk factor for atherosclerotic diseases such as CVD and carotid atherosclerosis, hypertension, type 2 diabetes mellitus (T2DM), metabolic syndrome (MS). There are complex interrelationships between hyperuricemia, T2DM, chronic kidney disease (CKD) and MS. The purpose of our study was to investigate the relationship between hyperuricemia, CKD, MS, and its components.Materials and methods: 179 patients with T2DM were included. The ...

ea0081p114 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Management of patients with Diabetes Mellitus and concurrent Covid-19 infection at a centre in Manchester with tertiary diabetes services: A retrospective single-centre audit

Mohammed Amr , Kapoor Ashutosh , Yar Malik Ganjera Asfand , Rao-Balakrishna Prasanna

Background: The prevalence rate of Diabetes within Manchester is higher than the national average of England. Association of British Clinical Diabetologists (ABCD) guidance highlights an increased risk of typical and atypical presentations of diabetic emergencies in patients with Diabetes and COVID-19. In the absence of early recognition and treatment, this could lead to adverse outcomes and poor prognosis, thus leading to increased mortality rates.Aims:...

ea0081p115 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Immunotherapy-induced Diabetes Mellitus is not uncommon

Bell Janessa , Bashir Mahamud , Rehmani Hassan , Mlawa Gideon

Background: Lung cancers are one of the leading causes of death worldwide which has resulted in an increase in immunotherapy, particularly immune checkpoint inhibitors (ICIs). Recent studies have shown induced endocrinopathies secondary to ICIs as a result of pancreatic beta cells, thyroid, and pituitary dysfunction.Aim: We aim to present an interesting case of Type 1 Diabetes mellitus secondary to immunotherapy. Pembrolizumab is used to treat melanoma, ...

ea0081p116 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association of uric acid levels with diabetic retinopathy in filipino patients with type 2 diabetes mellitus at a tertiary government hospital: a cross-sectional analytic study

Bariuad-Garcia Irene Kei , Jimeno Cecilia , Siopongco Paul

Objectives: Diabetic retinopathy, is the most frequent cause of new cases of blindness among adults aged 20–74 years in developed countries. In 15 of the 23 studies in developing countries and in ethnic minority groups within developed countries, the prevalence of diabetic retinopathy was over 35%. In developed countries, only 2 of 16 studies reported a prevalence of 35% or over. Variation in neither population demographics nor method of retinopathy assessment appeared to...

ea0081p117 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Sound mind at the expense of diabetes: olanzapine induced hyperosmolar hyperglycaemic state (HHS) in acute setting

Kessy Patricia , Mlawa Gideon , Ramachandran Kirtanya , Low Barney , Hossain Belayet , Rehmani Hassan , Saleem Muhammad , Bell Janessa

Background: Second generation antipsychotics (SGAs) are increasingly playing a bigger role in the treatment of schizophrenia and other psychiatric conditions due to their lower extra pyramidal side effect profile However, SGAs are known to cause clinically relevant metabolic derangements including hyperglycaemiaCase: A 70-year-old gentleman was admitted with generalised weakness and increased urinary frequency (polyuria) and polydipsia. His blood glucose...

ea0081p118 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association between hyperuricemia and degenerative complications of type 2 diabetes

Dalhoum Meriam , Hadj Ali Zohra , Ines Bani , Yosra Htira , Faika Ben Mami

Introduction: Hyperuricemia is associated with increased cardiovascular mortality and morbidity hence the interest in screening for hyperuricemia in the type 2 diabetic population.Objective: To investigate the association between hyperuricemia and degenerative complications in type 2 diabetics.Patients and Methods: This is a retrospective study including 130 patients followed in the C department of the National Institute of Nutriti...

ea0081p119 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Spondylodiscitis after diagnostic lumbar puncture in a post COVID -19, diabetic patient

Kermaj Marjeta , Shehu Tea , Troshani Jona , Hoxha Violeta , Poshi Klodiana , Ylli Dorina , Kito Jonida , Muco Ermira , Ylli Agron

Background: During the COVID-19 outbreak, there are rising concerns about long-term complications of COVID-19. On the other hand, discitis is a rare neurologic diagnosis, often delayed or missed due to the rarity of the disease. Patients usually present at an average age of 69 years with a history of diabetes or with a systemic infection. The lumbar spine is the most frequent site of infection (54%), and the cervical is the least at 10%. This is a case of post-COVID-19, diabet...

ea0081p311 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Oxidative stress decreased after six months testosterone treatment compared to placebo in ageing men – a randomized, double-blind trial

Christensen Louise Lehmann , Andersen Marianne , Enghusen Poulsen Henrik , Glintborg Dorte

Background: High oxidative stress is associated with increased morbidity. The effect of testosterone treatment (TT) on oxidative stress in ageing men with reduced bioavailable testosterone is undetermined.Aim: To determine the effect of TT compared to placebo on oxidative stress biomarkers.Methods: Double-blinded, placebo-controlled study in 38 men, aged 60–78 years, with bioavailable testosterone <7.3 nmol/l and waist cir...

ea0081p312 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Gastric dysmotility in diabetes

Inoyatkhodjaeva Irodakhon

The prevalence of diabetes is growing every year. One of the important complications of diabetes is the effect of diabetes on the gastrointestinal tract. Purpose of the study: to identify the frequency of delayed gastric emptying in patients with diabetes.Materials and methods: 122 patients with type 2 diabetes were examined for complaints from the upper gastrointestinal tract. For this, the GCSI questionnaire was used. After a thorough clinical, laborat...

ea0081p313 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Obesity and obesity-related diseases as a new clinical features in 3q27.3 microdeletion syndrome involving adipoq gene: a case study

De Brasi Davide , Novizio Vincenzo , Barba Livia , Scarano Elisabetta , Serino Domenico , Novizio Roberto , Della Monica Matteo , Petillo Roberta , Scavuzzo Francesco

Introduction: Adipose tissue is recognized as an important endocrine organ, secreting many endocrine factors. Adiponectin is the most abundant peptide released into circulation, encoded by ADIPOQ gene localized in chromosome 3q27.3. Adiponectin decreases intracellular ceramide, implicated in insulin resistance, inflammation and atherosclerosis. It stimulates fatty acid oxidation in skeletal muscle and inhibits glucose production in the liver. Hypo-adiponectinemia plays a centr...

ea0081p314 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetes and cervical pathologies: The phenotype and genotype connection

Gupta Prakhar , Bhadauria Shivani , Khanam Bushra

Cervical cancer is the fourth most common cancer among women globally and second most common in India. As per WHO, almost 90% of new cases and deaths worldwide, occurred in low to middle income countries in 2020. More than 95% of cervical cancers are associated with chronic Human papilloma virus infection (HPV), particularly of the types 16 and 18. High income countries have vaccination and screening programs that are in place for young girls but low-and middle-income countrie...

ea0081p315 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Participation in Diabefly® digital therapeutics program leads to significant improvement in glycemic control and reduction in weight and BMI among people with T2D

Verma Ritika , Khader Mohammed , Lathia Tejal , Tanna Snehal , Saraf Amit , Thakkar Piya Ballani , Raskar Vivek , Selvan Chitra , Guntur Saimala , Singal Arbinder

Background: People with chronic metabolic conditions such as type 2 diabetes (T2D) encounter challenges with self-management regimens to improve their glycemic control, weight and as well as to reduce complications associated with diabetes. Optimal management of T2D requires regular monitoring by physician, access to multidisciplinary care and achieving target HbA1c without hypoglycemia. Digital therapeutics (DTx) provide highly accessible, cost-effective, evidence-based solut...

ea0081p316 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Simultaneous pancreas-kidney transplantation: long-term survival and metabolic profile analysis among functioning pancreatic graft patients – A 20 year experience from a center in Portugal

Maia Ariana , Saraiva Miguel , Sala Ines , Soares Daniela , Borges Soares Diana , Monteiro Silvia , Vilaverde Joana , Ferreira Lia , Martins La Salete , Dores Jorge

Introduction: Simultaneous pancreas-kidney transplantation (SPKT) is the treatment of choice for type 1 diabetic patients with advanced kidney chronic disease (CKD), restoring normoglycemia, insulin independence and improving survival. The present study aims to analyse survival of patients undergoing SPKT and the post-SPKT metabolic profile of patients with a functioning pancreatic graft.Methods: Retrospective observational study. T1DM patients with CKD ...

ea0081p317 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Changing trends in the aetiology of diabetes-related ketoacidosis(DKA)- a blueprint to identify preventable causes

Rajendran Dineshwaran , Cooper Catherine , Alice Yip Wai Nga , Ponniah Gobeka , Anilkumar Anjitha , Zhou Dengyi , Soghal Shamanth , De Parijat , Sheikh Haaziq

Introduction: Diabetes-related Ketoacidosis (DKA) is a commonly-encountered acute endocrine emergency requiring prompt recognition and treatment. DKA is triggered by risk factors that are often preventable. There are limited studies evaluating the precipitating causes of DKA and depicting their trends over the years. The latter is important in the prevention of DKA by ensuring appropriate education and interventions.Aim: To study the trends of aetiologie...

ea0081p318 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of treatment of gestational diabetes mellitus with insulin on pregnancy outcomes

Lajili Olfa , Temessek Aroua , Rachdi Rim , Htira Yosra , Ben Mami Feika

Introduction: Gestational diabetes mellitus (GDM) complicates approximately 3% to 9% of pregnancies. Diagnosis and treatment of GDM remain essential to limit maternal and neonatal outcomes. The aim of the study was to evaluate the difference in pregnancy outcomes between insulin- and diet-treated tunisian women with gestational diabetes.Methods: It was a prospective longitudinal study including 220 patients followed for GDM at the research unit of the C ...

ea0081p319 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Feeding and DKA resolution

Fernandez Elaine Louise , Isidro Maria Jocelyn

Background: Diabetic ketoacidosis (DKA) is a complication of Diabetes Mellitus and is a life-threatening medical emergency usually requiring admission to an intensive care unit. There is no established guideline regarding timing of initiation of oral/enteral feeding in DKA patients.Purpose: To determine if there is a difference in clinical outcomes for DKA patients whose oral/enteral feeding was started early vs patients whose feeding was started beyond ...

ea0081p320 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Differences in diabetic neuropathy in type 1 and type 2 diabetes mellitus

Šiauliene Laura , Sereike Ieva , Rimantas Lazutka Juozas , Visockiene Zydrune

Background: Diabetic neuropathy (DN) is the most common chronic diabetes complication in type 1 (T1DM) and type 2 (T2DM) diabetes mellitus. Due to diagnostic issues, it is the least studied complication with limited and controversial data about the differences of various types of DN between T1DM and T2DM patients.Aim: To evaluate the differences of diabetic polyneuropathy (DPN) and cardiac autonomic neuropathy (CAN) - between T1DM and T2DM patients.<...

ea0081p321 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of a novel-app based strategy for carbohydrate counting on glucose control in type 1 diabetes

Briganti Silvia Irina , Strollo Rocky , Maggi Daria , Kyanvash Shadi , Lanza Oreste , Manfrini Silvia , Pozzilli Paolo

Background: carbohydrate counting is often performed inaccurately by patients with type 1 diabetes (T1D). We hypothesized that mobile App ‘Dietrometro’, that estimates CHO content of food figures, would ameliorate glucose control.Aim: To study the effect of ‘Dietometro’ on glucose control.Methods: 54 T1D subjects (aged 18-60 years, 26 males), on multiple daily injections (n=23) or continuous subcutaneou...

ea0081p322 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Higher levels of psychological stress are associated with lower levels of the insulin sensitizer FGF-21 in patients with obesity

Kuckuck Susanne , Lengton Robin , der Valk Eline S van , Iyer Anand M , Mohseni Mostafa M , Berg Sjoerd A A van den , van Rossum Elisabeth

Background: Altered signaling of hormones regulating appetite and metabolism is often observed in individuals with obesity (BMI ≥ 30 kg/m2) and related diseases, potentially resulting in increased hunger signaling and metabolic dysfunctions. Previous research indicates that such disturbances may be induced by weight gain itself, but also by other factors such as glucocorticoid excess (e.g. due to stress). However, knowledge regarding the associations between h...

ea0081p323 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Sleep quality in patients with type 1 diabetes: a large cross-sectional study

Bongiorno Claudio , Moscatiello Simona , Laffi Gilberto , Ribichini Danilo , Lo Preiato Valentina , Grimaldi Michele , Pagotto Uberto , Di Dalmazi Guido

Background: Altered sleep quality and duration have been reported in 26-67% of patients with type 1 diabetes (T1D). However, differences in study designs, populations, and methods of sleep quality assessment have led to heterogeneous results in terms of association with clinical data and blood glucose parameters.Aims: To investigate the sleep quality of a large cohort of adult patients with autoimmune diabetes under insulin treatment, and to analyze the ...

ea0081p324 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Characterization of the somatostatin and ghrelin hormonal systems revealed their potential therapeutic role in chronic liver disease

Herman Sanchez Natalia , Luis Lopez-Canovas Juan , Garcia-Estrada Antonio , Saez-Martinez Prudencio , Amado Victor , de la Mata Manuel , Cordoba-Chacon Jose , Sarmento-Cabral Andra , Rodriguez-Peralvarez Manuel , Luque Raul M. , Gahete Manuel D.

Hormonal signalling plays a key role in the progression of metabolic (dysfunction)-associated fatty liver disease (MAFLD) to hepatocellular carcinoma (HCC). However, the role of somatostatin (SST), cortistatin (CORT), neuronostatin (NST) and ghrelin systems in MAFLD-HCC progression has not yet been elucidated. We characterized the role of SST/CORT/NST and ghrelin systems in chronic liver disease and evaluated their clinical potential. The expression of the components of the SS...

ea0081p325 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association between the coefficient of glycemic variation and time in range, below and above range in continuous monitoring glucose systems in type 1 diabetes

Gomes da Costa Cristiana , Matos Tania , Vale Sonia

Introduction: Glycemic variability (GV) is a major consideration when evaluating quality of glycemic control. Coefficient of glycemic variation (%CV) is the metric of choice to define GV. International consensus on continuous glucose monitoring (CGM) recommends a %CV <36. Additional studies suggest that low %CV minimize hypoglycemia events <54 mg/dl.Aims: The aim of this analysis is to examine the expected relationship between the coefficient of ...

ea0081p326 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Personalized glycemic response based Diabefly-Pro® digital therapeutics improves dietary patterns, glycemic control and reduces postprandial hyperglycemia in real-world settings

Joshi Shilpa , Verma Ritika , Khader Mohammed , Nikte Sneha , Ade Suresh , Bandukwala Saifuddin , Joshi Mitali , Methil Vinod , Tiwaskar Mangesh , Singal Arbinder

Background: CGM based monitoring can help in development of personalized digital therapeutics programs based on the understanding of the effect of diet, physical activity and medications on everyday blood glucose excursions. The variation in intra-individual glycemic response to the same food has been reported in many studies. Thus, understanding of personalized glycemic response (PGR) of each individual becomes important for effective diabetes management.<p class="abstext...

ea0081p327 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Retrospective observational study of Italian patients with diabetes mellitus in Covid-19 era: a big data approach

Greco Carla , Pirotti Tommaso , Brigante Giulia , Filippini Tommaso , Pacchioni Chiara , Trenti Tommaso , Simoni Manuela , Santi Daniele

Introduction: The prevalence of diabetes mellitus (DM) in patients with coronavirus disease (COVID)-19 varies widely, depending on population characteristics, country, age and disease severity. Moreover, pre-existing DM seems to double the risk of both critical COVID-19 and mortality.Aim: To evaluate incidence and mortality risk of COVID-19 in a large diabetic population in Northern Italy.Methods: A retrospective, observational, bi...

ea0081p328 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

DKA registry: A step towards harmonising management of diabetes-related ketoacidosis in the United Kingdom-initial findings

Cooper Catherine , Rengarajan Lakshmi , Birchenough Amy , Sheikh Haaziq , Hebbar Meghnaa , Cuen Pan Carina Synn , De Parijat , Narendran Parth , Kempegowda Punith

Background: Diabetes-related ketoacidosis (DKA) is a common and potentially life threatening complication in people with diabetes. Despite national and international guidelines, interhospital guideline variation and mismanagement during admission are important contributory factors to increased DKA duration and length of stay.Aim: To establish a common DKA registry to identify gaps in management, assess outcomes and share best practises across centres.</p...

ea0081p329 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The relationship between clinically significant neonatal hypoglycemia and cord blood c-peptide levels in neonates of mothers with type 1 diabetes

Aharon-Hananel Genya , Levi Keren , Hemi Rina , Barhod Ehud , Kordi-Patimer Oshrit , Mazaki-Tovi Shali , Yoeli-Ullman Rakefet , Cukierman-Yaffe Tali

Introduction: Neonate of patients with type I diabetes (T1D) are at increased risk for neonatal hypoglycemia. It is hypothesized that this is a result of maternal hyperglycemia and subsequent fetal hyperinsulinemia.Aim: The aim of this study was to determine the relationship between clinically significant neonatal hypoglycemia (CS-hypo) and cord-blood c-peptide (CBCP) concentrations in patients with T1D.Materials and methods: This ...

ea0081p330 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Time of gestational diabetes diagnosis and neonatal outcomes

Morpurgo Paola S. , Peverelli Laura F. , Bolla Andrea M. , Gandolfi Alessandra , Vignali Michele , Spadaccini Giovanna , Fiorina Paolo

Background: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide, with considerable impact on the health of both mother and newborn. There is no doubt that screening for GDM between 24 and 28 gestational weeks (GWks) is important to reduce the risk of adverse outcomes; however, there is no clear consensus about the diagnosis and treatment of GDM in early pregnancy.Aims: To evaluate the effect of time of GDM diagnosis (early onset ...

ea0081p331 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Increasing overrepresentation of diabetes in non-traumatic lower limb amputations

Eik-Nes Sindre , Valland Susanna , Talsnes Ove , Ostlie Kristin , Holvik Kristin , Elisabeth Finnes Trine

Background and Aim: Recent international studies indicate a secular decrease in the proportion of patients with diabetes who undergo lower limb amputations (LLA), and the same trend is observed in the national quality indicator. The validity of electronic databases and quality indicators are limited by multiple discharges and precision of coding. Furthermore, amputation codes included in the quality indicator do not include all amputations. We therefore aim to investigate the ...

ea0081p332 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

COVID-19 pneumonia patients with 25(OH)D levels lower than 12 ng/ml are at increased risk of death

Smaha Juraj , Kužma Martin , Brazdilova Kristina , Nachtmann Samuel , Jankovsky Martin , Pastirova Katarina , Gažova Andrea , Jackuliak Peter , Killinger Zdenko , Kyseloviž Jan , Koller Tomaš , Binkley Neil , Payer Juraj

Objectives: There is no consensus about specific serum 25(OH)D levels associated with higher risk of severe outcome in COVID-19 patients. According to the literature patients with serum 25(OH)D levels < 12 ng/ml are clearly deficient at all ages. Our aim was to assess COVID-19 mortality in the settings of severe 25(OH)D deficiency.Methods: A cohort study of 357 COVID-19 patients was conducted. Subjects were monitored until discharge or in-hospital de...

ea0081p333 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

REAL Life study of SEMaglutide in Patients with Type 2 diabetes in SPain (REALSEM-SP): Retrospective clinical study on the efficacy, adherence, and safety with Semaglutide

Cardenas Salas Jersy Jair , Poyatos Roberto Miguel Sierra , Luiza Luca Bogdana , Sanchez Lechuga Begona , Modrono Mostoles Naiara , Montoya Alvarez Teresae , GoMez Montes Maria De La Paz , Sanchez-Lopez Raquel , Casado Carlos , Vazquez Martinez Clotilde

Introduction: Real-world data on glucose and weight control effectiveness in patients with Type 2 diabetes mellitus (T2DM) on treatment with semaglutide is scarce. We aim to assess it in a cohort of patients from a real-world setting in Spain.Materials and methods: We identified 830 patients with T2DM that were prescribed Semaglutide once-weekly since May 2019 to December 2020, in 4 hospitals in Madrid-Spain. At 6±3 months, 435 GPL1-naïve and 3...

ea0081p334 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Health outcomes following engagement with a digital health tool GroHealth app amongst people with type 2 diabetes

Abdelhameed Farah , Pearson Elle , Hanson Petra , Barber Thomas , Panesar Arjun , Summers Charlotte , de la Fosse Michaela

Introduction: Diabetes is a chronic condition causing morbidity and mortality globally, with a growing economic burden on healthcare systems. In the UK, 1 in 14 people have diabetes, with type 2 accounting for 90% of cases (1). Complications from poorly controlled diabetes are associated with increased socioeconomic costs and a reduced quality of life. Research has shown education and self-management are crucial in helping diabetic patients achieve metabolic control (1). Smart...

ea0081p335 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of amputation in a group of long-standing type 1 diabetic patients

Bornaz Emna , Abdesselem Haifa , Sebai Imene , Meherzi Amal , Ounaissa Kamilia , Boukhayatia Fatma , Brahim Asma Ben , Yahiaoui Rim , Amrouche Chiraz

Background: Amputation is the major complication of diabetic foot. The aims of our study were to assess prevalence of amputation in a group of long-standing type 1 diabetic patients and to determine its risk factors.Methods: We conducted a cross-sectional study including type 1 diabetic patients followed at the National Institute of Nutrition of Tunis. All patients had a duration of diabetes ≥ 20 years. Clinical and biological data were collected f...

ea0081p336 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is there a relationship between nonalcoholic fatty liver disease (NAFLD) and atheroma disease?

Leon Mengibar Josep , Lopez Carolina , Zorzano Marta , Soler Beunza Ana Gloria , De La Fuente Maricruz , Herrerias Fernando , Vilardell Felip , Santamaria Maite , Lecube Albert

Introduction: Over the last few years, there are some studies that suggests a close connection between Nonalcoholic Liver Disease (NAFLD) and increased cardiovascular (CV) risk in population with obesity. Indeed, these two conditions share common drivers, most notably insulin resistance and other elements of the metabolic syndrome. Notwithstanding the above, this affirmation does not have solid scientific evidence. The proliferation of Vasa Vasorum (VV) in the adventitial laye...

ea0081p337 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Roux-en-Y gastric bypass and vertical sleeve gastrectomy showed similar efficacy in achieving cardiometabolic composite target in subject with type 2 diabetes undergoing bariatric surgery

Monte Lavinia , Tuccinardi Dario , Rossini Giovanni , Watanabe Mikiko , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Introduction: The American Diabetes Association (ADA) produced a triple composite outcome that summarizes the therapeutic targets of the three most prevalent complications of obesity: type 2 diabetes (T2D), hypertension and dyslipidemia (HbA1c <7.0%; LDL cholesterol<100 mg/dl and systolic blood pressure <130 mmHg). The present study primarily investigates the difference between VSG and RYGB in achieving the composite target one year after the surgery. The secondary...

ea0081p338 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of dietary protein source on body composition and cardiometabolic risk in young adults with obesity during anti-inflammatory weight management program

Jovanovic Gordana Kendel , Majanović Sanja Klobučar , Sutic Ines Mrakovcic , Rahelic Dario

Introduction: Many studies have shown that dietary protein content may play a role in weight management. Moreover, it has been found that diets high in protein (either animal or plant) significantly reduced markers of insulin resistance and hepatic necroinflammation independently of body weight change. This study aimed to examine the effect of dietary protein source on body composition and cardiometabolic risk factors in young adults with obesity during anti-inflammatory weigh...

ea0081p339 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Autoimmune thyroiditis: What impact on diabetic retinopathy ?

Bornaz Emna , Abdesselem Haifa , Hkiri Ghofrane , Ounaissa Kamilia , Boukhayatia Fatma , Sebai Imene , Ben Brahim Asma , Yahiaoui Rim , Amrouche Chiraz

Introduction: Data from literature suggest that combination of autoimmune diseases may have a major physical and psychological impact on type 1 diabetic patients. The aim of our study was to assess the impact of autoimmune thyroiditis on diabetic retinopathy.Methods: We conducted a descriptive observational retrospective study of type 1 diabetic patients, followed at the National Institute of Nutrition and Food Technology of Tunis, between December 2019 ...

ea0081p340 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Excellent disease control in Berardinelli Seip type 1 patient through dietary therapy alone: only an exception?

Cecchetti Carolina , Belardinelli Elisabetta , Dionese Paola , Teglia Rita , Di Cintio Ilaria , D'apice Maria Rosaria , Pagotto Uberto , Gambineri Alessandra

Background and Objective: Severe metabolic complications generally manifest at an early age in Berardinelli – Seip congenital lipodystrophy (BSCL) and their management is especially challenging, often requiring prompt pharmacological treatment with insulin-sensitizers, lipid lowering drugs, insulin and eventually metreleptin. Nutritional intervention with low lipid personalized diets is considered by experts a fundamental tool in handling the disease when associated with ...

ea0081p341 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of the mode of insulin delivery on the quality of life of type 1 diabetes patients

Tzivian Lilian , Sokolovska Jelizaveta , Grike Anna E. , Kalcenaua Agate , Seidmann Abraham , Benis Arriel , Mednis Martins , Danovska Ieva , Berzins Ugis , Bogdanovs Arnolds , Syundyukov Emil

Background: Insulin pump therapy is an alternative to multiple daily injections and can improve glycemic control and quality of life (QoL) in Type 1 diabetes mellitus (T1DM) patients. The aim of this study was to assess the differences and factors related to the T1DM-specific QoL of T1DM patients in Latvia.Methods: 87 adult patients with T1DM were included. Of them, 20 were pump users and 67 were users of injections. All recruited patients participated i...

ea0081p342 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

IGF1-zSDS in patients suffering from obesity with or without metabolic syndrome: a cross-sectional study in 2032 subject

Masi Davide , Risi Renata , Tozzi Rossella , Gangitano Elena , Curreli Mariaignazia , Watanabe Mikiko , Mariani Stefania , Gnessi Lucio , Lubrano Carla

Background: Metabolic syndrome (MS) is associated with increased mortality, and the key factors predictive of its development among patients with obesity are still unclear. We recently demonstrated with a machine learning approach that Insulin-like Growth Factor 1 (IGF-1) is a novel marker of metabolic health and that in individuals with obesity, lower IGF-1 levels are associated with increased metabolic deterioration. However, the interpretation of IGF-1 serum measurement is ...

ea0081p343 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Exposing the crosstalk between obesity and prostate cancer: miR-191-5p as personalized diagnostic and therapeutic tool

Porcel-Pastrana Francisco , Herrero-Aguayo Vicente , Saz-Martinez Prudencio , Jimanez-Vacas Juan M. , Carrasco-Valiente Julia , Lopez-Miranda Josa , Gomez-Gomez Enrique , Sarmento-Cabral Andra , Gahete Manuel D. , Luque Raul M.

Prostate cancer (PCa) is one of the most common causes of cancer-related deaths in men worldwide. Therefore, more specific non-invasive diagnostic biomarkers as well as novel therapeutic targets are urgently needed. As miRNAs have been proposed as promising elements for the identification of novel diagnostic and therapeutic tools for different pathologies, including cancer, we investigated the miRNA landscape in PCa patients and explored their putative diagnostic/therapeutic u...

ea0081p344 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Case Report: A triad of Diabetic Ketoacidosis, hypertriglyceridaemia and acute pancreatitis as a first presentation of diabetes mellitus

Dadey Ebo , Perumbalath Jesmith , Leonard David , Mlawa Gideon

Objective: We present a case of hypertriglyceridemia induced acute pancreatitis (HTG-AP) and concurrent diabetic ketoacidosis (DKA) as a first presentation of Diabetes Mellitus in an adult patient. This uncommon triad has been previously described in the literature, however, it is rare to be observed in a previously undiagnosed patient with diabetes. The purpose of this poster is to describe the potential mechanisms for this and discuss management strategies.<p class="abst...

ea0081p345 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Understanding and improving the management of hyperosmolar hyperglycaemic state

Cuen Pan Carina Synn , Warmington Emily , Rengarajan Lakshmi , Cooper Catherine , Owen Megan , Sheikh Haaziq , Anilkumar Anjitha , Dhatariya Ketan , Webber Jonathan , Kempegowda Punith

Background: Hyperosmolar hyperglycaemic state (HHS) is an acute metabolic complication of diabetes that can lead to significant morbidity and mortality if managed incorrectly. With <1% prevalence, there is limited published literature available on HHS and most management guidelines worldwide are based solely on expert advice and opinions.Aims: To study the precipitating causes and identify baseline practises of HHS management, to highlight areas for ...

ea0081p346 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Combination study of apoptosis gene polymorphisms in mitochondrial diabetes: Potential role in the pathogenesis of mitochondrial diabetes

Kacem Akid Faten Haj , Mohamed Ahmed Mohamed Abdellahi , Nesrine Dhieb , S Youssef , E Mkaouar-Rebai , F Fakhfakh , Mnif Mouna , Abid Mohamed

Introduction: Mitochondrial diabetes (DM) is a monogenic form of maternal transmission diabetes that is caused by mutations in the mitochondrial genome. These mutations affecting mitochondrial function may be the cause of initiation of the phenomenon of apoptosis itself having an aggravating role of the phenotype in patients with mitochondrial diabetes.Materials and Methods: This study involved 43 patients with mitochondrial diabetes (20 non-syndromic an...

ea0081p347 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Uncommon side effect of a common drug: doxycycline induced hypoglycaemia

Ijete Elohor , Hosni Moustafa , Dadey Ebo , Nikookam Khash , Rehmani Hassan , Mlawa Gideon

Introduction: Doxycycline is a broad-spectrum antibiotic that is used to treat gram negative, gram positive and atypical bacterial infections. It is a member of the second-generation tetracycline class of antibiotics.Case: We describe a case of a (non-diabetic) male patient who developed hypoglycaemia following treatment with doxycycline. A 73-year-old male presented to the emergency department following a witnessed collapse at 9am on the 4tho...

ea0081p348 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of intermittently scanned continuous glucose monitoring on the glycemic control and treatment satisfaction in Korean type 2 diabetic patients

Lee Junghoon

Background: In recent years, continuous glucose monitoring (CGM) has emerged as a method for the assessment of glycemic control. Also CGM enables diabetic patients to understand their own blood glucose status and change their lifestyle.Aims: We investigated the effect of CGM on the glycemic control in Korean type 2 diabetic patients.Methods: We enrolled type 2 diabetic patients who met all the following criteria: 1) use of oral ant...

ea0081p349 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

User acceptance and satisfaction with the eversense XL CGM in patients with type 1 diabetes

Javier Martinez Martin Francisco , Hernandez-Lazaro Alba , de Leon-Durango Ricardo , Kuzior Agnieszka , Arnas-Leon Claudia , Acosta-Calero Carmen

Objectives: Eversense XL is a fully implantable sensor for continuous glucose monitoring (CGM) that lasts for up to 180 days. Our objective was to perform a survey on user acceptance and satisfaction among our type 1 diabetic patients who had been using the Eversense XL CGM for at least 3 months.Methods: A questionnaire was devised in which the patients were asked about their experience with the Eversense XL CGM, including:-Compari...

ea0081p350 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of autoantibodies in paediatric and adult patients with type 1 diabetes mellitus – study of a Portuguese cohort

Cosme Ines , Silvestre Catarina , Nunes Daniel , Lemos Carlos , Joao Bugalho Maria , Proenca Helena

Introduction: Almost all type 1 diabetes mellitus (T1DM) patients have autoantibodies (ab) at disease onset. These ab prevalence varies according to patients’ age, origin and disease duration.Aim: Determine diabetes mellitus ab prevalence in a paediatric and adult T1DM Portuguese according to their age on diagnosis, gender and diabetes duration.Methods: Retrospective review of T1DM ab (glutamic acid decarboxylase 65 autoantibo...

ea0081p351 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Glucokinase (GCK) diabetes

Abouzaid Mona , MacLeod Jean , Aggarwal Naveen

Background: Glucokinase (GCK) is a gene which plays an important role in recognising how high the blood glucose is in the body. It acts as the glucose sensor for the pancreas. Changes in the GCK gene can lead to increases in blood glucose and affected people may be diagnosed with diabetes although this rise in blood glucose is mild and does not need treatment. Glucokinase diabetes is one of familial diabetes types that called MODY (maturity onset diabetes of the young). We rep...

ea0081p352 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effects of an acute metreleptin injection on hepatic lipid metabolism in patients with lipodystrophy

Beghini Marianna , Metz Matthaeus , Wolf Peter , Bastian Magdalena , Hackl Martina , Baumgartner-Parzer Sabina , Kautzky-Willer Alexandra , Trauner Michael , Marculescu Rodrig , Krebs Michael , Harreiter Jurgen , Wabitsch Martin , von Schnurbein Julia , Brandt-Huenemann Stephanie , Stumvoll Michael , Miehle Konstanze , Santini Ferruccio , Ceccarini Giovanni , Magno Silvia , Pelosini Caterina , Krssak Martin , Pfleger Lorenz , Stangl Herbert , Furnsinn Clemens , Scherer Thomas

Objective: Treatment with metreleptin ameliorates hepatic steatosis in patients with lipodystrophy. The anti-steatotic effect of metreleptin is partially independent of its anorexic action, which suggests a direct effect of metreleptin on hepatic lipid metabolism. However, this mechanism is unknown. Based on previous findings in rodents, we hypothesized that metreleptin reduces hepatic lipid content by stimulating very-low density lipoprotein triglyceride (VLDL1-TG) secretion,...

ea0081p353 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evaluating obesity among second and third age premature children

Jha R K , Chandra A K

Introduction: Premature newborns are defined as babies born before 37 weeks of pregnancy and after 22 weeks of pregnancy as a viability limit. This study aimed to analyse growth characteristics at the age of second and third age and the prevention of metabolic diseases that may occur in adult age at an early phase.Methods: This study was conducted as a retrospective cohort study between May 2021 and October 2021 in 18 different Outpatient Clinics in Patn...

ea0081p354 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Higher glucocorticoid receptor sensitivity is associated with less favorable body composition in patients with obesity

Lengton Robin , Iyer Anand , Valk Eline van der , Voorn Bibian van der , van Rossum Elisabeth

Background: Mounting evidence points to an association between increased glucocorticoid (GC) action and weight gain. However, the response to GCs is not only determined by GC serum concentrations, but also by individual differences in tissue-specific sensitivity, influenced by genetic and acquired (e.g. disease-related) factors. The extent to which differences in GC sensitivity may influence development of (abdominal) obesity, or vice versa, is poorly understood. In this study...

ea0081p355 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

GLP-1 receptor agonists and erectile dysfunction in diabetic men with and without hypogonadism: a 1- year retrospective observational study

Lisco Giuseppe , Isabella Ramunni Maria , De Pergola Giovanni , Jirillo Emilio , Guastamacchia Edoardo , Triggiani Vincenzo , Angelo Giagulli Vito

Background: Erectile dysfunction affects nearly half of men with type 2 diabetes (T2DM), and one-third of diabetic men have hypogonadism1. As an add-on to TRT in hypogonadal men with T2DM, Liraglutide may improve erectile function2, and dulaglutide decreased the incidence of moderate and severe ED in T2DM3.Study aims: To assess the GLP-1RA effect in T2DM men complaining of ED treated with both liraglutide and dulaglutide ...

ea0081p356 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence and awareness of complications in type 2 diabetes mellitus : a hospital based comparative cross-sectional study

Mainali Uttar Kumar , Kamat Laxmi Narayan , Khatri Sanjeep , Acharya Den Prasad

Introduction: Diabetes Mellitus appears to be globally pandemic and is drawing attention as a major public health concern. Chronic complications of this disease can lead to poor quality of life with significant financial burden to family and country as well. The current study aims to assess prevalence of such complications and its awareness in type 2 diabetes population.Methods: This descriptive cross-sectional study was conducted during one year period ...

ea0081p357 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Assessment of risk of foot ulceration in a group of long-standing type 1 diabetic patients

Bornaz Emna , Abdesselem Haifa , Dridi Manel , Hasni Yosra , Ounaissa Kamilia , Boukhayatia Fatma , Sebai Imene , Ben Brahim Asma , Yahiaoui Rim , Amrouche Chiraz

Background: Diabetic foot represents a serious complication due to its prevalenceas well as its impact on functional and vital prognosis of the diabetic patient. The aim of our study was to assess the risk of foot ulceration in a group of long-standing type 1 diabetics.Methods: We conducted a descriptive observational cross-sectional study including type 1 diabetic patients who had diabetes for more than 20 years, followed at the National Institute of Nu...

ea0081p358 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Long-standing type 1 diabetes and female sexuality : Is there impact ?

Bornaz Emna , Abdesselem Haifa , Salem Amal , Ounaissa Kamilia , Boukhayatia Fatma , Sebai Imene , Brahim Asma Ben , Yahiaoui Rim , Amrouche Chiraz

Background: While sexual dysfunction in men with type 1 diabetes is well known, sexual dysfunction in women remains a neglected issue. The aim of this study was to assess the sexual quality of life (SQOL) of women with long-standing type 1 diabetes.Methods: We conducted a cross-sectional study of women followed at the National Institute of Nutrition and Food Technology of Tunis. We included women with type 1 diabetes for 20 years or more. Women who were ...

ea0081p359 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

New insights into obesity treatment provided by smart technologies and telemedicine

Jakubikova Iva , Štolbova Kristyna , Novodvorsky Peter , Dvořakova Iveta , Doležalova Barbora , Kalina Szabolcs , Raška Petr , Kautzner Josef , Haluzik Martin

Introduction: Obesity represents a major public health challenge and is linked with increased risk of multiple medical conditions including atrial fibrillation (AF). We have recently published the study protocol of the ‘The Effect of complex weigHt-reducing interventiOns on rhythm control in oBese subjects wITh Atrial Fibrillation’ (HOBIT-AF) trial. Here we communicate the preliminary results with the focus on the use of smart technologies and telemedicine.<...

ea0081p360 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Functional analysis of melanocortin-4 receptor variants linked to obesity

Virginia Alejandra , Rondon Rodriguez , Huisman Martin , Welling Mila , Akker Erica van den , Rossum Elisabeth van , Delhanty Patrick , Visser Jenny

Introduction: Melanocortin-4 receptor (MC4R) is a G-protein-coupled receptor expressed in regions of the hypothalamus regulating appetite and energy expenditure. Extensive evidence from genetic and biological studies show that MC4R is a key player in the homeostatic regulation of body weight. MC4R loss of function (LoF) variants are the most common cause of monogenic obesity. We have identified 13 heterozygous MC4R variants in patients with obesity at our academic Obesity Cent...

ea0081p361 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Comparison of glycemic variability in type 2 diabetes mellitus patients on oral anti diabetic drugs (OAD) with and without insulin using ambulatory glucose profile (AGP)

S Sidharth , Aggarwal Ramesh , Prakash Anupam , Ghotekar L H , Aggarwal Meenakshi

Introduction: Assessment of diabetes with daily blood glucose fluctuations including peaks and nadirs forms the crux of the modern management. Use of glycemic variability (GV) as a parameter to assess these fluctuations is emerging. Diabetes mellitus patients follow different clinical trajectories which can be traced by the ambulatory glucose profile (AGP) obtained from flash glucose monitoring system (FGMS).Methodology: This comparative observational st...

ea0081p362 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Morphofunctional assessment of cancer patient’s nutritional status receiving systemic treatment and oral nutritional supplements

Leon-Idougourram Soraya , Garcia-Ramirez Mireia , Manuel Alzas-Teomiro Carlos , Manzano-Garcia Gregorio , Munoz-Jimanez Concepcion , Jesus Calanas-Continente Alfonso , Rodriguez-Alonso Rosa , Molina-Puerta Maria Josa , Angeles Galvez-Moreno Maria , Herrera-Martinez Aura Dulceida

Introduction: Disease-related malnutrition is one of the main factors associated with morbidity and mortality in cancer patients. Furthermore, maintaining and improving muscle mass and function are important to achieve an optimal nutritional status. In this sense, the role of leucine-enriched essential amino acids supplementation for the therapeutic approach to the promotion of muscle anabolism stands out.Methods: 46 cancer patients with malnutrition rec...

ea0081p363 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evaluation of the Ankle-brachial index in a group of long-standing type 1 diabetic patients

Bornaz Emna , Abdesselem Haifa , Moalla Hajer , Souissi Nesrine , Ounaissa Kamilia , Boukhayatia Fatma , Sebai Imene , Ben Mami Feyka , Amrouche Chiraz

Background: Lower extremity artery disease (LEAD) is a common complication of diabetes, with increasing prevalence with duration and/or the coexistence of other cardiovascular risk factors. The Ankle-brachial index (ABI) is the first diagnostic step after clinical examination, for screening and diagnosis of LEAD. The aim of our study was to evaluate the ABI in a group of long-standing type 1 diabetic patients.Methods: We conducted a cross-sectional study...

ea0081p364 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Acute hemolytic anemia due to glucose-6-phosphate dehydrogenase deficiency during treatment of diabetic ketoacidosis in an African American patient diagnosed with Ketosis-prone diabetes

Tsakalomatis Panagiotis-Nikolaos , Daraki Vasiliki , Vamvoukaki Rodanthi , Mytilinaiou Maria , Syntzanaki Eleni-Konstantina , Kontolaimaki Kalliopi , Chrysoulaki Maria , Sfakiotaki Maria , Venetsanaki Vasiliki , Bouki Katerina , Betsi Grigoria , Xekouki Paraskevi

Background: Diabetic ketoacidosis (DKA) has been associated with severe hemolysis in patients with Glucose-6-phosphate dehydrogenase (G6PD) deficiency after restoration of euglycemia. Less than 30 cases have been reported so far. The exact mechanism is not fully understood.Case presentation: A 35-year-old African American man presented to the emergency department with polyuria, polydipsia, abdominal pain and weight loss the last 15 days. Physical examina...

ea0081p365 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Flash glucose monitoring in patients with DM3c

Rebollo-Roman Angel , Leon-Idougourram Soraya , Manuel Alzas Teomiro Carlos , Moreno-Moreno Paloma , Angeles Galvez Moreno Maria

Objective: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Since November 2020 the use of this system is subsidized in patients with type 3c diabetes (DM3c) Our objective was to describe the characteristics of these patients and their glycemic control expressed as times in range.Methods and patients: Observational longitudinal clinical study between January 2021 and December 2021 in patients with DM3c in which FGM implementat...

ea0081p366 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of glucose monitoring on quality of life

Verissimo David , Ivo Catarina , Duarte Vitoria , Claudia Martins Ana , Silva Joao , Lopes Luis , Passos Dolores , Castro J Jacome , Marcelino Mafalda

Introduction: The quality of life (QoL) of patients with Diabetes has been the subject of several studies worldwide. In Portugal, studies have shown that patients under intensive insulin therapy had worse results in QoL questionnaires. The introduction of interstitial glucose monitoring (IGM) appears to reduce the impact of insulin therapy on QoL.Objective: To assess whether IGM changes the quality of life of patients with diabetes, compared to the asses...

ea0081p367 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metformine: anti-fibrotic molecule?

Khelifi Dayssem , Ben Nacef Ibtissem , Bouzid Kahena , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

Background and aims: Diabetes causes tissue fibrosis by still poorly understood mechanisms which involve glycation products. Galectin-3 (Gal-3) is an emerging key player in metabolic disorders and a powerful factor in the development and progression of the fibrotic process in target organs in diabetic patients. The plasma level of Gal-3 increases during diabetic cardiomyopathy and diabetic nephropathy. We have studied the correlation between serum Gal-3 level and anti-diabetic...

ea0081p368 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Comparative analysis of clinical, obstetric and perinatal characteristics of pregnant women according to serum levels of vitamin D

Simon Frapolli Victor Josa , Fernandez Valero Andrea , Fuentes Miguel Damas , Molina Vega Maria , Picon Casar Maria Josa , Tinahones Madueno Francisco Josa

Introduction: Vitamin D is considered a fat-soluble vitamin and a fundamental prohormone in mineral and bone metabolism, with an immunoregulatory, cardiovascular and neuroprotective effect, among others. Vitamin D can be found as vitamin D2 or ergocalciferol and vitamin D3 or cholecalciferol. The main source of vitamin D comes from ultraviolet radiation in sunlight, but it is also obtained through food. Vitamin D deficiency is very prevalent in Europe, with a significant peak ...

ea0081p369 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A role for somatostatin in regulating weight regain after bariatric surgery in mice

Kleiman Doron , Arad Yhara , Permyakova Anna , Tam Joseph , Ben-Haroush Schyr Rachel , Ben-Zvi Danny

Somatostatin is a hormone and neuropeptide expressed in the pancreas, gastrointestinal tract, hypothalamus, and other tissues. It regulates directly the secretion of insulin, glucagon, many of the gastrointestinal hormones, and growth hormone. It is therefore surprising the somatostatin knockout (sst-ko) mice have a very mild phenotype. We subjected sst-ko mice and heterozygous siblings which served as controls to a high-calorie diet, and confirmed that sst-ko mice gain weight...

ea0081p370 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Differential localisation of the A-ring reductases in human hepatocytes: implications for substrate preference and utilisation

Potter Tom , da Conceicao Ismael , Nikolaou Nikolaos , Loh Nellie , Tomlinson Jeremy , Gathercole Laura

The 5-reductases are steroid metabolising enzymes that saturate the C4=C5 bond of the steroid A-ring, and their substrates include androgens, glucocorticoids, and bile acids. 5β-reductases (SRD5A1 & SRD5A2) convert testosterone to the more potent androgen 5β-dihydrotestosterone, and carry out the first step in glucocorticoid clearance, generating 5β-dihydrocortisol from cortisol. 5β-reductase (AKR1D1) is also able to carry out the first step of glucocor...

ea0081p371 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Body composition in patients undergoing liver transplantation

Argente Pla Maria , Garcia-Malpartida Katherine , Lopez-Gironas Regina , Martin-Sanchis Silvia , Mico-Garcia Andrea , Gasco Eva , Dura-De Miguel Angela , Hernandez Lorena , Vera Elena , Merino Torres Juan Francisco

RationaleLiver cirrhosis frequently leads to changes in body composition consisting of a loss of lean mass, increased body water and variable alterations of fat mass. Changes in body composition may occur after liver transplantation (LT). Our aim was to study the changes that occur in body composition after LT (in the postoperative period after LT as well as 1 month later). Methods: A body composition study was carried out using th...

ea0081p372 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of diabetes mellitus on patients’ quality of life

Verissimo David , Ivo Catarina , Duarte Vitoria , Martins Ana Claudia , Silva Joao , Lopes Luis , Passos Dolores , Castro J Jacome , Marcelino Mafalda

Introduction: Diabetes is a disease with great psychosocial impact and reduced quality of life (QoL), and psychosocial factors seem to be excellent predictors of clinical outcomes.Objective: Assess the relationship between the patient’s perception of diabetes management and its impact on QoL.Methods: Interview of patients with type 1 (T1D) and type 2 diabetes (T2D), using the ‘Appraisal of Diabetes Scale’ (ADS), a qu...

ea0081p373 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Auto-immune diabetes associated with systemic scleroderma: a case report

Ouakrim Hind , Natacha Bilihi , Rafi Sana , Mghari Ghizlane El , Ansari Nawal El

Introduction: The association of multi-organ autoimmune diseases is described. We report a case of association between Latent autoimmune diabetes in adults (LADA) and systemic scleroderma (SSc), which remains a rarely reported entity in the literature.Observation: 38-year-old female patient, followed for systemic scleroderma with digestive and pulmonary involvements. The patient presented a dysphagia to solids with dyspnea installed in the last 2 months,...

ea0081p374 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Threshold value of galectine-3 in a Tunisian diabetic population

Khelifi Dayssem , Nacef Ibtissem Ben , Bouzid Kahena , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

Background and aims: Plasma Galectin-3 (Gal-3), mediator of fibrogenesis and inflammation, has been implicated in many diseases. Particularly in diabetics, this lectin directly mediates transdifferentiation in collagen-producing cells thus leading to fibrosis of target organs and accelerating the development of complications. The objective of our study was to determine a cut-off value for Gal-3 in our population.Methods: We conducted a cross-sectional, a...

ea0081p375 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

More than 20 years after diagnosis of type 1 diabetes: what about the quality of life?

Bornaz Emna , Abdesselem Haifa , Sdiri Chaima , Ounaissa Kamilia , Boukhayatia Fatma , Sebai Imene , Brahim Asma Ben , Yahiaoui Rim , Amrouche Chiraz

Background: Long-standing type 1 diabetes, had many complications which have an impact on both life expectancy and quality of life of these patients. The aims of our study were to evaluate the quality of life of a group of Tunisian patients with type 1 diabetes evolving for more than 20 years as well as to determine the factors associated with its alteration.Methods: We conducted a descriptive observational cross-sectional study including type 1 diabetic...

ea0081p376 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetic retinopathy and erectile dysfunction: is there a relationship ?

Bornaz Emna , Abdesselem Haifa , Msolly Skander , Ounaissa Kamilia , Fatma Boukhayatia , Sebai Imene , Brahim Asma Ben , Yahiaoui Rim , Amrouche Chiraz

Background: Erectile dysfunction impairs the quality of life of men with type 1 diabetes. Many factors are involved in this complication. According to the literature, diabetic microangiopathy is associated with erectile dysfunction. The aim of our study was to evaluate the impact of diabetic retinopathy on erectile dysfunction in a group of long-standing type 1 diabetics.Methods: We conducted a cross-sectional study that included male patients with type ...

ea0081p377 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabesity showcases the need for intensive care for COVID-19

Das Ak , Guha Shaibal , Kumar Subhash , Shankar Anand

Background: Old age is proven to be one of the greatest danger factors for intensively dealing with COVID-19 patients. Stoutness and diabetes are enhancers of dangers among COVID-19 patients. In any case, there exists restricted proof for the modifiable danger components, for example, bodyweight which is an indicator of the Intensive Care Unit and its need among type 2 diabetes patients. In this review, the subject of body weight as an indicator of ICU confirmations will be in...

ea0081p568 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Study of musculoskeletal manifestations in type 2 diabetes mellitus

Payra Biswajit , Jain Sachin K. , Prakash Anupam , Sud Alok , Sud Ritika , Aggarwal Ramesh

Introduction: Musculoskeletal manifestation is one of the leading cause of morbidity and disability among type 2 diabetics. Also management of these conditions with steroids and non-steroidal anti-inflammatory drugs, adversely impact the glycaemic control of diabetics. Our study aims to look for prevalence of different musculoskeletal manifestation among type 2 diabetes.Methodology: Our study is a cross-sectional observational study and it is comprised o...

ea0081p569 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metabolic dysfunction–associated fatty liver disease and cardiovascular risk characterization

Perdomo Carolina M. , Nunez Jorge , Casajus Ana Ezponda , Mendoza Francisco J. , Aleman Gorka Bastarrika , Fruhbeck Gema , Escalada Javier

Objectives: Metabolic dysfunction–associated fatty liver disease (MAFLD) is a new nomenclature for fatty liver disease (FLD). The clinical impact of the change in nomenclature on the ability to identify individuals at risk for cardiovascular disease (CVD) has not yet been elucidated. The aim of this study is to describe the cardiovascular risk and subclinical CVD of the different MAFLD subtypes.Methods: Retrospective analysis of patients who attende...

ea0081p570 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

When and How to Screen for Glucose Dysregulation (GD) in patients with β-Thalassemia Major (β-TM): A retrospective study by The International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescent Medicine (ICET-A)

De Sanctis Vincenzo , Soliman Ashraf , Daar Shahina , Tzoulis Ploutarchos , Karimi Mehran , Di Maio Salvatore , Kattamis Christos

To investigate the best criteria and time to diagnose dysglycemia in β-TM patients, the ICETA performed a retrospective study on glycemic abnormalities (GD) in 397 with β-TM patients (aged 5–40 years; 56.3% males) followed between 1988 to 2021 in a single centre (by VDS) (40 years).Methods: Fasting blood glucose (FPG) and standard oral glucose tolerance test (OGTT) results were collected over 40 years of follow up and results were categori...

ea0081p571 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Glycogen hepatopathy- a rare and frequently misdiagnosed hepatic complication of diabetes mellitus

Mangaraj Swayamsidha

Introduction: Glycogenic hepatopathy(GH) refers to excessive intrahepatic glycogen accumulation in patients with poorly controlled diabetes mellitus especially type 1 diabetes mellitus. It is a rare and frequently misdiagnosed complication of diabetes mellitus. The patients present with non-specific pain abdomen may be incidentally detected during evaluation of deranged liver function tests(LFT).Case report: A 15 years old female presented with pain abdo...

ea0081p572 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Telephone support program for patients with type 2 diabetes under treatment with insulin glargine 300 u/ml (t-coach) in the area of cadiz (spain)

Cornejo Dominguez Jesus Manuel , Sanchez Toscano Esteban , Mateo Gavira Maria Isabel , Garcia Garcia-Doncel Lourdes , San Laureano Carral Florentino

Introduction: The T-Coach® telephone support program for patients with type 2 diabetes (DM2) treated with insulin glargine 300 u/ml, facilitates dose adjustments of basal insulin therapy through regular telephone consultations and offers diabetes education in order to improve empowerment of the patient. Objective: To assess the usefulness of the T-Coach® program in metabolic control and degree of satisfaction in patients with T2DM.Patients and ...

ea0081p573 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Total daily dose of insulin at the beginning of treatment with Continuous Subcutaneous Insulin Infusion system: which is the best formula?

Benido Silva Vania , Garrido Susana , Vilaverde Joana , Teixeira Sofia , Cardoso Maria Helena

Introduction: Several formulas are described to calculate the Insulin Dose to start insulin pump therapy. However, there are no data demonstrating their effectiveness in achieving good glycemic control.Aim: To assess the Total Daily Dose of Insulin (TDDI) at 3 months after beginning an insulin pump, and determine which formula most closely matches the TDDI required in cases where good glycemic control is achieved after that period....

ea0081p574 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of whatsapp based Communication on insulin adherence and glycemic control in patients with Diabetes in Indian population

Saboo Bharat , Shrivastav Abhishek , Saboo Banshi , Inamdar Aniket

Introduction: Diabetes treatment requires the involvement of people with diabetes in the form of medication adherence. Insulin treatment is an important aspect of diabetes therapy. Regular and timely insulin therapy is necessary for good glycaemic control and complications prevention. Newer follow-up techniques, such as WhatsApp based communication are now finding their way into diabetes care and treatment. It can assist diabetes patients to maintain a regular treatment schedu...

ea0081p575 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Maturity-onset diabetes of the young in a large portuguese cohort

Santos Monteiro Silvia , Fonseca Liliana , Santos Tiago S. , Assuncao Guilherme , Lopes Ana M. , Duarte Diana B. , Soares Ana Rita , Laranjeira Francisco , Oliveira Maria Joao , Borges Teresa , Cardoso Maria Helena

Introduction: Monogenic forms of diabetes that develop with autosomal dominant inheritance are classically aggregated in the maturity-onset diabetes of the young (MODY) categories. Despite increasing awareness, its true prevalence remains largely underestimated.Aim: o evaluate the clinical and molecular characteristics of patients with MODY.Methodology: This single-center retrospective cohort study enrolled patients with positive g...

ea0081p576 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Ketosis prone type 2 diabetes in covid times - a missing link?

Sharma Bhavna , Rahman Mushtaqur

Traditional literature agrees that Diabetic Ketoacidosis is typically associated with Type 1 Diabetes Mellitus, but can be associated with stress including infections in Type 2 diabetics. The authors did a restrospective evaluation of diabetic ketoacidosis presenting to a large district hospital in London. 343 patients were admitted with diagnosis of Diabetic Ketoacidosis during the COVID peaks from January 2020 to January 2021. 57% of these were Type 1 diabetics and 43% were ...

ea0081p577 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Covid-19, Dexamethasone and Diabetes(CODED) study: a single centre experience

Meneissy Noha , Waring Scott , Farhana Umme , Kasigwa Sarah , Wang Yishan , Rashid Tasfia , Kim Sohee , Paul Shanta , Hlaing Htet Myat , Darego Sukuta , Siddika Sadia , Nachas Olga , Fahal Lamis , Mahamud Bashir , Mlawa Gideon

Coronavirus (COVID-19) caused by severe acute respiratory syndrome (SARS)-CoV-2, which leads to multi-organ disease. Covid-19 high mortality and morbidity arising from autoimmune destruction of the lungs due to pro-inflammatory cytokines storm, has enabled worldwide collaborative studies aimed at elucidating potential management strategies in order to overcome pandemic. The RECOVERY trial, a multi-centred trial involving 175 United Kingdom based hospitals. The results from thi...

ea0081p578 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Inflammatory markers in patients with type 1 diabetes and diabetic kidney disease

Fedulovs Aleksejs , Jekabsons Kaspars , Kunrade Lıga , Puzirevska Irena , Folkmane Inese , Sokolovska Jelizaveta

Background: Inflammation is involved in the pathogenesis of complications of type 1 diabetes (T1DM). We aimed to assess the differences in the markers of endotoxaemia and faecal calprotectin in patients with T1D different status of diabetic kidney disease (DKD).Methods: 31 generally healthy adults (control) and 74 patients with T1DM and were included. Of the latter, 13 had DKD (defined as microalbuminuria, macroalbuminuria, estimated glomerular filtratio...

ea0081p579 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association between clinical and genetic factors and glycemic and weight loss response to liraglutide in patients with type 2 diabetes

Kyriakidou Artemis , Kyriazou Angeliki V. , Koufakis Theocharis , Vasilopoulos Yiannis , Grammatiki Maria , Mellidou Eirini , RAKITZI PANTELITSA , Karaliolios Georgios , Goulis Dimitrios , Zebekakis Pantelis , Kotsa Kalliopi

Background: Previous research suggests an association between specific genetic variations and interindividual variability in response to treatment with glucagon-like receptor agonists (GLP-1 RAs) in patients with type 2 diabetes mellitus (T2DM). We aimed to evaluate the role of CTRB1/2 rs7202877 (T>G) polymorphism in glycemic control and weight loss response to liraglutide among Greek patients with T2DM and to identify clinical factors related to prediction of res...

ea0081p580 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hypoglycemia and impared hypoglycemia awareness: frequency and relevance in type 1 diabetes under continuous subcutaneous insulin infusion

Mafalda , Carreira Ana , Vieira Ines , Barros Luisa , Melo Miguel , Rodrigues Dircea , Oliveira Patricia , Baptista Carla , Moreno Carolina , Paiva Isabel

Introduction: Continuous subcutaneous insulin infusion (CSII) therapy in type 1 diabetes (T1D) reduces the risk of hypoglycemia. Hypoglycemia remains a treatment-limiting factor. Impared hypoglycemia awareness (IHA) occurs in 25% of T1D cases and seems to be underestimated by continuous glucose monitoring (CGM). Glycemic variability (GV) is a increasingly valued parameter as a predictor of hypoglycemia and risk of chronic complications.Objective: Analysi...

ea0081p581 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Comparing global rating scores from simulation-based diabetes and endocrine scenarios between healthcare professionals of high- and low- and middle-income countries

Abdi Zakee , Zhou Dengyi , Malhotra Kashish , Ali Anisah , Sheikh Jameela , Sakthivel Pavithra , Warmington Emily , Cuen Pan Carina Synn , Chen Wentin , Kaur Harjeet , Nirmal Rachel , Soran Vina , Allison Isabel , Evans Nia , Delson Dwi , Davitadze Meri , Kempegowda Punith , Simulation Simba

Background: Simulation via Instant Messaging - Birmingham Advance (SIMBA) is an online simulation learning modality designed to recreate clinical scenarios, allowing participants to increase their confidence in a safe environment without compromising patient safety. The global rating scale (GRS) is a commonly used assessment tool in medical schools to assess participant competence and skills. Following SIMBA sessions, an independent assessor anonymously scores participants&#14...

ea0081p582 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetic foot association with premature cardiovascular mortality in a single centre prospective of study of people with diabetes

Tesic Dragan , Andric Dragica , Tomic Miroslav-Tomislava , Andric Stefan , Tomic Mirjana

Background and aims: In many developing countries, diabetic foot is considered as a problem only when the patient develops a wound on the foot. Until that moment, the detection of changes in the neurovascular condition of the feet is rarely applied. The aim of this prospective, single centre study was to define factors associated with early cardiovascular mortality in diabetes.Materials and methods: 1345 patients under age 75 were included who were under...

ea0081p583 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Waist-to-height ratio is a predictor of weight loss with Gelesis200 treatment for people with overweight or obesity having prediabetes or type 2 diabetes in the LIGHT-UP study

Luzi Livio , Greenway Frank , Miller Sam , Matejkova Erika , McLean Barry , Zmuda Witold , Bogdanski Pawel , Arciszewska Malgorzata , Sjodin Anders , Salz Judith , Bochenek-Mularczyk Anna , Lewy-Alterbaum Lorena , Butcher Michael , Paragh Gyorgy , Davis Yvonne , Wilding John , Golub Howard , Leider Harry , Zohar Yishai , Sannino Alessandro , Calderon Henry , Heshmati Hassan

Introduction: Methods to predict clinically meaningful weight loss can help tailor treatment for people with overweight or obesity. LIGHT-UP (NCT03058029), is a multicenter, double-blind, randomized, placebo-controlled study over 25 weeks including 254 people with prediabetes or type 2 diabetes (127 each in the Gelesis200 and placebo arms) with a body mass index between 27 and 40 kg/m2, which demonstrated that Gelesis200 offers a compelling new potential approach in...

ea0081p584 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Gastroesophageal lesions after bariatric surgery: a controlled study

Ivo Catarina , Verissimo David , Duarte Vitoria , Claudia Martins Ana , Silva Joao , Lopes Luis , Passos Dolores , Jacome Castro Joao , Marcelino Mafalda

Introduction: Obesity is a multifactorial and chronic disease. Bariatric surgery (BS) is the most effective treatment. A prevalence of 45% of esophagitis and 40%-70% of gastritis after BS has been reported. We analysed the presence of gastroesophageal lesions in patients who underwent BS (By-pass Roux-en-Y(BP) and gastric sleeve(GS)) in our centre.Methods: Patients submitted to BS between 2018-2020 were included. We retrospectively analysed clinical data...

ea0081p585 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Improvements in physiological and psychological status of patients with obesity in response to a combined lifestyle intervention with cognitive behavioral therapy are not necessarily related to successful weight loss

Mohseni Mostafa , Kuckuck Susanne , Meeusen Renate , Lengton Robin , van der Valk Eline , Iyer Anand M. , de Groot Corjan , van den Berg Sjoerd , van Rossum Elisabeth F.C.

Background: Obesity (BMI ≤ 30 kg/m2) is a chronic and relapsing disease, associated with numerous co-morbidities. Lifestyle intervention is the cornerstone of treatment of obesity, and is considered effective when weight loss of ≤ 5% is achieved. Here, we describe changes in physiological, psychological and behavioral health outcomes in response to a multidisciplinary combined lifestyle intervention (CLI).MethodsIn this longitudinal study we evaluated 97...

ea0081p586 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Weight loss variability with SGLT2 inhibitors, GLP-1 receptor agonists and repetitive Transcranial Magnetic Stimulation in Type 2 Diabetes and Obesity: results of a retrospective, comparative study

Ferrulli Anna , Massarini Stefano , Cannavaro Daniele , Perilli Paolo , Terruzzi Ileana , Senesi Pamela , Luzi Livio

Weight loss in individuals with Obesity (O) and Type 2 Diabetes (T2D), may improve glycaemic control and weight-related comorbidities, and in some cases, induce diabetes remission. However, body weight control is generally an unmet aim in this population. Thus, there is an increasing need to consider pharmacological approaches to assist weight loss in diabetes-obesity. Glucose-lowering agents as the sodium-glucose co-Transporter 2 inhibitors (SGLT2i) and GLP-1 Receptor Agonist...

ea0081p587 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

GLP-1 and glucagon depict complementary actions on visceral adipose tissue that could mediate metabolic shifts towards catabolism

Morais Tiago , Seabra Alexandre , Patricio Barbara , Guimaraes Marta , Nora Mario , Oliveira Pedro , Alves Marco , Monteiro Mariana

Visceral adipose tissue (VAT) metabolic fingerprints differ according to the individual’s BMI and glycemic status. GLP-1 and Glucagon are two hormones that participate in energy homeostasis and glycemic control. Dual GLP-1/Glucagon agonists are a drug class under development for obesity and diabetes treatment. Although the pancreas and the liver are considered major GLP-1 and glucagon targets, these hormones act in other tissues, which could contribute for its effects on ...

ea0081p588 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Influence of diabetes and metabolic risk factors on the outcomes of COVID-19 Vaccination: Scoping Review of the Observational Studies

Trivedi Shailesh , Trivedi Renu , Trivedi Akta

Introduction: Obesity and diabetes are the known risk factors for severity and susceptibility to severe COVID-19 with a poor prognosis. However, there is limited evidence for the implications and association of metabolic factors on COVID-19 vaccination.Methods: We systematically searched PubMed/Medline and Cochrane library till January 28, 2022, using: (“diabetes OR BMI OR weight OR glucose OR obesity OR metabolic” and “COVID OR Coronaviru...

ea0081p589 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Utility of webinars with case-based learning approach in teaching endocrinology to undergraduate medical students during the COVID-19 pandemic

Goyal Kashish , Malhotra Kashish , Kansal Rohin , Marwah Mahima , Goyal Ravikant , Goyal Harry , Galhotra Anmol

Background: Conventional methods of one-way teaching may not involve the integration of clinical skills and may become more inefficient and passive [1]. During the COVID-19 pandemic, limited patient interaction and shift to online lectures greatly reduced the clinical exposure and opportunity of developing interpersonal skills for junior medical students. In this study, we hosted online webinars with case-based teaching for medical students so that they can amalgamate clinical...

ea0081p590 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Type 1 diabetes on continuous subcutaneous insulin infusion: impact of glycaemic control on quality of life

Carreira Ana , Ferreira Mafalda , Vieira Ines , Lavrador Mariana , Barros Luisa , Baptista Carla , Moreno Carolina , Melo Miguel , Paiva Isabel

Background: In type 1 diabetes (T1D), quality of life (QoL) and the effectiveness of treatment influence each other. QoL has been associated with glycaemic control assessed by HbA1c in T1D on continuous subcutaneous insulin infusion (CSII), but data on the relationship between Continuous Glucose Monitoring (CGM) metrics and QoL are scarce.Objectives: To assess QoL and the association between CGM metrics and QoL in T1D on CSII.Metho...

ea0081p591 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Systematic review of ongoing clinical trials assessing the comparative therapeutic efficacy and safety of insulin glargine 300 u/ml with insulin degludec

Chakravorty Saibal , Chakravorty Aditya , Belagodu Monica

Introduction: To systematically evaluate the study designs and the outcomes being analysed in the ongoing trials evaluating the efficacy and safety of Insulin Glargine 300 U/ml with insulin degludecMethods: We reviewed contemporary protocols of trials that are currently ongoing through WHO-ICTRP (www.who.int/ictrp/search/en), www.clinicaltrials.gov trials registry database. Latest evaluation was on January 28, 2022 with key word ‘insulin galrgaine U...

ea0081p592 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Risk of developing type 2 diabetes in young adults with a psychiatric disorder: a nationwide population-based cohort study

Min-Kyung Lee , Sohn Seo-Young , Ahn Jiyeon , Han Kyungdo , Lee Jae-Hyuk

Objective: Having a psychiatric disorder may increase the risk of developing type 2 diabetes (T2D) and we aimed to determine whether young adults with a psychiatric disorder have an increased risk of developing T2D.Research Design and Methods: We conducted a nationwide cohort study to evaluate the association of different psychiatric disorders with the risk of T2D in the young population. Records of 6.457.991 adults aged 20−39 years without a histo...

ea0081p593 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hyperglycemia, but not previous diagnosis of diabetes mellitus, is an independent indicator of poor outcome in patients hospitalized for severe COVID-19

Eletto Elisa , Dei Cas Alessandra , Nouvenne Antonio , Ticinesi Andrea , Prati Beatrice , Spigoni Valentina , Aldigeri Raffaella , Cinquegrani Gloria , Schiro Silvia , Ruffini Livia , Sverzellati Nicola , Meschi Tiziana , Bonadonna Riccardo C.

Background: Both diabetes mellitus and hyperglycemia are reported to be strong risk factors for poor outcome(s) in patients hospitalized for COVID-19. However, their relative roles in affecting patient prognosis are under debate.Aims: To evaluate the independent influence of known diabetes mellitus and hyperglycemia on death/admission to intensive care unit (ICU) in patients hospitalized for COVID-19 during the first wave of SARS-Co-V2 pandemic.<p cl...

ea0081p594 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Circulating levels of endothelial progenitor cells (EPCs) and sexual function in fertile women with type 1 diabetes

Maio Antonietta , Tomasuolo Maria , Porcellini Chiara , Sarnataro Annalisa , Pernice Vlenia , Castellano Laura , Caruso Paola , Esposito Katherine

Introduction: Female sexual dysfunctions (FSD) are complex conditions characterized by impairment of the female sexual cycle. Higher prevalence of FSD has been found in women with diabetes, as compared with matched healthy controls. Endothelial progenitor cells (EPCs) are circulating mononuclear cells participating in the neo-angiogenesis. There is evidence that circulating levels of EPCs are reduced in diabetic patients compared with age-matched subjects. The relationship bet...

ea0081p595 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Somatostatin analogue treatment for hyperinsulinemic hypoglycemia with glucokinase activating mutation (GCK), c.295T>C (p.Trp99Arg)

Boguslawska Anna , Rzepka Ewelina , Kluczyński Lukasz , Hubalewska-Dydejczyk Alicja , Gilis-Januszewska Aleksandra

Somatostatin analogues (SSA) are used to treat different forms of hyperinsulinemic hypoglycemia (HH) in children and adults and therapeutic effect is achieved by suppressing insulin secretion from pancreatic β-cells by complex mechanisms. These treatments might be associated with several side effects, can even cause the worsening of severity of hypoglycemia. This is a report of the treatment of HH with SSA in patient with Activating Mutation (GCK), c.295T>C (p.Trp99Ar...

ea0081p596 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Transient Refractory Hyperinsulinemic Hypoglycemia

Berquist John , Wahl Matthew

Fasting hypoglycemia in the setting of hyperinsulinemia typically is persistent and often progressive. We present a case where fasting hypoglycemia with hyperinsulinemia was transient in nature over a fortnight. This occurred in the setting of recurrent seizure-like activity. Seizures are a well known sequela of hypoglycemia; however, the reverse is not nearly as well documented. A 20 year old male with a history of developmental delay, chronic PEG tube, and nonverbal at basel...

ea0081p597 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The impact of changes to Joint British Diabetes Societies’ diabetes-related ketoacidosis management guidelines on trends of complications and outcome

Ponniah Gobeka , Birchenough Amy , Owen Megan , Cuen Pan Carina Synn , Soghal Shamanth , Warmington Emily , Sheikh Haaziq , Ali Karamat Muhammad , Saraf Sanjay , Kempegowda Punith

Background: Serious complications of diabetes-related ketoacidosis (DKA) and its management with fixed rate insulin infusion (FRIII) include hypoglycaemia, hyperkalaemia and hypokalaemia. Revised Joint British Diabetes Societies for Inpatient Care (JBDS) guidelines in July 2021 recommended a reduced rate FRIII of 0.05 units/kg/hour from 0.1 units/kg/hour once blood glucose levels fall to ≤14.0 mmol/l to alleviate the risk of these complications.Aim...

ea0081p598 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of Bariatric Surgery on the liver - An adolescent cohort

von Hafe Madalena , Chaves Joana , Neves Joao Sergio , Borges-Canha Marta , Vale Catarina , Lourenco Ines , Corujeira Susana , Campos Miguel

Introduction: Obese patients are at an increased risk of develop nonalcoholic fatty liver disease. Evidence supports that bariatric surgery might have an important impact on hepatic profile in obese adults. Literature suggests that bariatric surgery in adolescents might decrease the prevalence of some comorbidities, but information about its impact on liver profile and steatosis and fibrosis risk remains scarce.Aim: To evaluate the impact of bariatric su...

ea0081p599 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of bariatric surgery on metabolic profile − a pediatric cohort

von Hafe Madalena , Chaves Joana , Sergio Neves Joao , Borges-Canha Marta , Vale Catarina , Corujeira Susana , Campos Miguel

Introduction: Obesity is a complex multifactorial disease and its prevalence in pediatric age has increased. Obesity prejudices the individual metabolic profile due to the adipotoxicity involved in this condition. Bariatric surgery improves the weight of obese patients along with metabolic comorbidities, being today one of the most effective treatments for obesity. Time of exposure to adipotoxicity appears to be an important risk factor for the development of metabolic complic...

ea0081p600 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Esr1 and Esr2 estrogen receptors have different functions in Glut4 expression of 3t3-l1 cells

Pancera Laurindo Caroline , Cristina Rego Gregorio Karen , Fabres Machado Ubiratan

Diabetes mellitus (DM) is an important cause of morbidity and mortality on a global scale. The pathophysiology of DM involves insulin resistance, even in insulin-treated type 1 DM, which in turn is related to the amount of glucose transporter GLUT4 (Slc2a4 gene). Estrogen activity can be mediated by two distinct receptors (ESR1 and ESR2) and may involve genomic and non-genomic mechanisms. Estrogen has been described as involved in glycemic homeostasis, but the related...

ea0081p601 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Isoflavones genistein and daidzein enhance the expression of Slc2a4 mRNA and GLUT4 protein in adipocytes

Rego Gregorio Karen Cristina , Pancera Laurindo Caroline , Fabres Machado Ubiratan

According to the world Health Organization, about 422 million people worldwide have diabetes mellitus (DM), and this number is growing rapidly. DM, mainly type 2, is associated with insulin resistance, which involves reduced expression of glucose transporter GLUT4 (Slc2a4 gene). It is known that estrogen can modulate glycemic homeostasis and seems to involve changes in the Slc2a4/GLUT4 expression. There has been an increased interest in plant-derived phytoest...

ea0081p602 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Mediterranean Diet and 12 months weight loss result in complex serum metabolomic and fecal metaproteomic changes in paediatric obesity

Spadaccini Daniele , Vita Vanella Virginia , Barberis Elettra , Ricotti Roberta , Bellone Simonetta , Bona Elisa , Antoniotti Valentina , Caputo Marina , Mancioppi Valentina , Rabbone Ivana , Manfredi Marcello , Prodam Flavia

Background: The relationship between composition and function of microbiota, obesity and nutrition has been increasingly studied and is still a challenge.Aims: To test whether in a group of 12 pediatric patients with obesity the treatment with a structured hospital and in-home Mediterranean Diet intervention had an impact on gut microbiota composition, function, and metabolite production, including Short chain fatty acids (SCFAs).M...

ea0081p603 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Ghrelin deficiency sex-dependently alters food intake, locomotor activity, and white adipose tissue gene expression in a binge-eating mouse model

Prins Karina , Delhanty Patrick , Huisman Martin , Mies Rosinda , McLuskey Anke , Visser Jenny

Binge-eating disorder is the most prevalent eating disorder diagnosed, affecting three times more women than men. It is characterised by binge-eating episodes: the rapid consumption of a large amount of food, without needing the calories. The gut hormone ghrelin stimulates appetite and reward signalling, and loss of its receptor reduces binge-eating behaviour in male mice. We aimed to examine the influence of ghrelin itself on binge-eating behaviour in mice of both sexes. 5-we...

ea0081p604 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Glucocorticoids enhance browning and thermogenic functions of mouse and human white adipocytes

Kasarla Ramesh , Gesmundo Iacopo , Congiusta Noemi , Sabbia Greta , Pardini Barbara , Bocchiotti Maria Alessandra , Ghigo Ezio , Granata Riccarda

White adipose tissue (WAT) stores excess energy as triglycerides, while brown adipose tissue (BAT) dissipates energy through heat, acting as a defence against cold and obesity and as a positive regulator of metabolic functions. BAT thermogenic functions are mainly induced by mitochondrial uncoupling protein-1 (UCP-1), which induces uptake of lipids and glucose to sustain oxidation and thermogenesis in both brown and beige adipocytes. Beige/brite adipocytes arise in WAT depots ...

ea0081p605 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effects of Long-term (five years) prednisone therapy in frequently relapsing nephrotic syndrome of childhood: impact on glycemia and the different components of the metabolic syndrome (MetS)

Elbaba Mostafa , Hamed Noor , Soliman Ashraf , Alyafei Fawzia , Itani Maya , Al-Naimi Fatima , Al Yousef Doaa , Dalees Mona Shaat

Although widely prescribed for their anti-inflammatory and immunosuppressive properties, glucocorticoids have various common metabolic side effects including hypertension, dysglycemia and diabetes. Aim: This study was carried out to investigate the prevalence of different metabolic components and dysglycemia in children with steroid sensitive nephrotic syndrome (SSNS) with multiple relapses for 5 years in relation to the cumulative dose of steroids.<...

ea0081p606 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The ecology of the microbiome in children with congenital generalized lipodystrophy type 4 (CGL4) is quickly modified after metreleptin treatment

Daffara Tommaso , Mancioppi Valentina , Caputo Marina , Bellone Simonetta , Massa Nadia , Caramaschi Alice , Mignone Flavio , Romanisio Martina , Rabbone Ivana , Giordano Mara , Aimaretti Gianluca , Bona Elisa , Prodam Flavia

Introduction: Lipodystrophy syndromes are characterized by a progressive metabolic impairment secondary to adipose tissue dysfunction and genetic background. The role of microbiota is still uninvestigated.Objective: Evaluate the gut microbiome ecology in relation to dietary and clinical parameters in two infant siblings with congenital generalized lipodystrophy type 4 (CGL4) before and after treatment with recombinant leptin.Method...

ea0081p607 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

An audit of management of severe hyperlipidaemia in secondary and primary care services in greater london area

Sharma Bhavna , Fatima Anees

Hyperlipidaemia services in the UK are guided by National Guidance for Lipid Management for primary and secondary prevention of cardiovascular disease. Our audit studied a total of 71 patients in primary and secondary care in the greater London area with total Cholesterol levels greater than 7.5 mmols/l. In patients admitted to hospital (n=22); 27.8% patients were ITU admissions with 56% being under surgical team for acute pancreatitis. Only 45.4% of these patients we...

ea0081p608 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Dysregulation of cytochrome P450 oxidoreductase (POR) in NAFLD and hepatocellular carcinoma; evidence from clinical, rodent and cellular models

da Conceicao Ismael , Nikolaou Nikolaos , Gathercole Laura , Harris Shelley , Dempster Niall , Moolla Ahmad , Hodson Leanne , Tomlinson Jeremy

The incidence of non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, continues to rise. NAFLD is associated with significant liver-specific and cardiovascular morbidity and mortality, including hepatocellular carcinoma (HCC). Currently, there are no licensed therapies, highlighting the importance of understanding the pathogenic mechanisms that drive the condition. Cytochrome p450 oxidoreductase (POR) plays an essential role in activa...

ea0081p609 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Modern method of diagnosing of cerebral microangiopathy in patients with diabetes mellitus type 2 by doppler ultrasound

Adkhamova Madina , Karimova Dilfuza , Mirzaeva Rakhshona

Background: To identify opportunities for Doppler ultrasound in the diagnosis of cerebral microangiopathy in patients with diabetes mellitus type 2 and hypertension.Methods: The study included the diagnosis of 72 patients with type 2 diabetes and hypertension who were hospitalized in the 2 and 3 clinics TMA. The control group consisted of 25 patients aged 61.9 ± 2.6 years, suffering from type 2 diabetes. The study group included 47 patients (19 men ...

ea0081p610 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of the COVID-19 pandemic on diabetic foot

Ragbi Sara , Amal Mjabber , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: The COVID-19 pandemic has presented many challenges in the management of diabetics around the world. While many people can be managed using new methods such as tele-consulting, the diabetic foot presents unique challenges due to the frequent need for “face-to-face” consultation and treatment. The pandemic has thus made the management of diabetic feet, already complex, even more difficult. This study aims to assess the impact of the COVID-19 pandemic on ...

ea0081p611 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Influence of dopamine receptor d2 and dopamine transporter polymorphisms in angiopathy in patients with type 2 diabetes mellitus

Neves Marta , Santos Ana Carolina , Ferreira Joana , Raposo Joao F. , Valente Ana , Bicho Manuel

Introduction and Aim: Dopamine receptor D2 (DRD2) polymorphism (rs1800497) appears to be associated with increased susceptibility to the development of type 2 diabetes mellitus (T2DM). The dopamine transporter (DAT) determines dopamine signalling, responsible for the reuptake of its active form from the synapse. Polymorphism in the DAT gene (rs2836317) can increase dopamine reuptake in the synaptic cleft. However, its association with T2DM is still controversial.<p class="...

ea0081p612 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

An Experience of Insulin Basal Titration in Lombardy (Italy) during the Pandemic

Disoteo Olga Eugenia , Dodesini Alessandro Roberto , Solerte Bruno , Desenzani Paolo , Erpoli Paolo , Manfrini Roberto , Molteni Laura , Carlo Bossi Antonio

Introduction: Correct titration of basal insulin is one of the most important conditions allowing Type 2 Diabetes Mellitus patients to reach correct and personalised fasting plasma glucose. The persistence of the pandemic, together with the persistence of the SARS-CoV2 virus made titration process more complex, and pushed the Lombardy diabetologists to develop solutions which could be handled by the patient independently, or with the remote online assistance of diabetes team.<...

ea0081p613 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Use of continuous glucose monitoring for treatment adjustment in type 2 diabetes patients

Totomirova Tzvetelina , Arnaudova Mila

Continuous Glucose Monitoring (CGM) is proved to be useful for dose adjustment in patients treated with multiple insulin injection regimens or with continuous subcutaneous insulin infusion. CGM give precise information about glucose variability in type 1 diabetes but are rarely used in type 2 patients. We assessed continuous glucose monitoring systems (CGMs) as control assessment tool in patients with type 2 diabetes receiving different treatment regimens. We studied 85 patien...

ea0081p614 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Dopaminergic system and adipose tissue: in vitro effect of cabergoline on white, brown and beige adipogenesis and lipogenesis processes

Negri Mariarosaria , Pivonello Claudia , Amatrudo Feliciana , Patalano Roberta , Monto Tatiana , Angelis Cristina de , Simeoli Chiara , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario

Adipose tissue is an endocrine organ releasing adipokines and expressing specific markers and intracellular mediators, which regulate whole-body energy by balancing lipid accumulation and utilization through adipogenesis, the differentiation of preadipocytes into mature adipocytes associated with gradual lipid storage, and lipogenesis, the additional lipid accumulation in mature adipocytes. Adipogenesis and lipogenesis, strongly induced by insulin, occur in white adipocytes, s...

ea0081p615 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is age-related hepatic elevation of endogenous SERM 27-hydroxycholesterol associated with hepatocellular degeneration female-specific? − Results from Rat study

S.ošić-Jurjević Branka , Jovanović Ljubiša , Marina Ljiljana , Ristic Natasa , Miler Marko , Ajdžanović Vladimir , Filipović Branko , Luetjohann Dieter

The cholesterol oxidation product 27-hydroxycholesterol (27OHC) is enzymatically produced from cholesterol by CYP27A1 in an alternative pathway of cholesterol degradation to bile acids. This oxysterol also acts as an endogenous selective estrogen receptor modulator (SERM). In healthy humans its concentration in circulation increases in hypercholesterolemia and with age, and is associated with increased risk of atherosclerosis, cardiovascular diseases and breast cancer. Several...

ea0081p616 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Ketogenic diet is protective against atherosclerosis development in Apolipoprotein E Knockout Mice

Marzolla Vincenzo , Mammi Caterina , Feraco Alessandra , Gorini Stefania , Armani Andrea , Caprio Massimiliano

Objective: higher aldosterone (aldo) levels are associated with increased risk of cardiovascular ischemic events and mortality. It has been demonstrated that aldo accelerates the development of aterosclerosis in apolipoprotein E knockout mice (ApoE KO). Ketogenic diet (KD) positively impacts several cardiovascular risk factors, yet its effect on atherosclerosis, is elusive. We hypothesize that, KD protects from development of atherosclerotic plaques in ApeE KO mice, a murine m...

ea0081p617 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

place of plasma injections rich in autologous platelet in the management of diabetic foot ulcer (preliminary results)

Steve Kamgain Simeu Lionel , Amal Mjabber , Essabah Haraj Nassim , Aziz Siham El , Chadli Asma

Introduction: Diabetic foot ulcer (DFU) is one of the leading causes of non-traumatic lower extremity amputations worldwide. Conventional treatment is expensive and often requires a long hospital stay, placing a heavy burden on any healthcare system. Using autologous platelet-rich plasma (PRP), which is rich in various growth factors, can approximate the natural healing process.Objective: Evaluate the place of PRP injections and its interest in the manag...

ea0081p618 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of teaching communication techniques to family member on quality of life score in patients with T2DM

Saboo Bharat , Saboo Shweta , Inamdar Aniket

Introduction: Impact of teaching communication techniques to family member on quality of life score in people with T2DM.Communication holds an important place in Diabetes management. People with diabetes usually have low self esteem. Proper communication with them can help in improving quality of life of people with diabetes. Family plays an integral part in Diabetes management. Benefits of proper communication has long been seen in various studies. ...

ea0081p619 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Injection of epidermal growth factors in the treatment of diabetic foot ulcers

Ragbi Sara , Amal Mjabber , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: Diabetic foot ulcer (DFU) is one of the major complications of diabetes mellitus. It can be a cause of amputation. A multidisciplinary approach is essential to promote wound healing and decrease amputation rates. Epidermal growth factor (EGF) is used as an adjuvant to close the wound in addition to standard care in diabetic foot ulcers.Methods: This is a prospective study carried out between February 2019 and April 2021 in the department of...

ea0081p620 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetes and spontaneous miscarriage

Dalhoum Meriam , Ali Zohra Hadj , Bani Ines , Ben Mami Faika , Htira Yosra

Introduction: Early spontaneous miscarriage is common in diabetic women and has an unknown mechanism. This rate of spontaneous miscarriage is directly correlated to the glycemic control at the beginning of pregnancy.Objective: To assess the frequency of spontaneous miscarriage in women with diabetes.Patients and Method: This is a retrospective study including 50 diabetic women followed at department C of the National Institute of N...

ea0081p621 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Phase angle, a raw bioelectrical impedance analysis (bia) variable, as a prognostic factor for mortality at 90 days in patients with covid-19

Cornejo-Pareja Isabel , Vegas-Aguilar Isabel Ma , Garcia-Almeida Jose Manuel , Fernandez Valero Andrea , Tinahones Francisco J

Introduction: COVID-19 has taken on pandemic proportions. Phase angle (PhA) and Standardized phase angle (SPhA) have been related to mortality and severity in several diseases.Objetives: To determine the predictive role of PhA and SPhA on 90 days survival of adults with COVID-19.Methods: A longitudinal cohort study with 127 consecutive patients diagnosed with COVID-19. We collected PhA, SPhA, body composition (fat mass, fat free ma...

ea0081p622 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Disturbances in melatonin, leptin and ghrelin rhythms in women with metabolic syndrome with and without polycystic ovary syndrome

Nyagolova Presiyana , Mitkov Mitko , Peneva Vanya , Terzieva Dora

Background: Polycystic ovary syndrome (PCOS) is a highly prevalent heterogeneous disease associated with ovulatory dysfunction and hyperandrogenemia. Recent data support a critical role of neuroendocrine dysfunction and metabolic disturbances in the pathophysiology of the syndrome, including hyperleptinaemia. Accumulating evidence suggests that circadian desynchrony is linked to obesity and metabolic syndrome (MetS). Both prevalence and incidence of the metabolic syndrome is v...

ea0081p623 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metabolic Syndrome (MetS) Criteria in children with steroid-sensitive Nephrotic syndrome (SSNS) and frequent relapses treated with long-term prednisone therapy (LTPT) vs normal obese children

Soliman Ashraf , Elbaba Mostafa , Hamed Noor , Dalees Mona Shaat , Itani Maya , Al-Naimi Fatima

Steroid-associated adverse events (SAAE) include hypertension, hyperglycemia, and diabetes, overweight and obesity and short stature.Aim: The goal of this study was to assess the occurrence of steroid-associated metabolic and clinical adverse events (SAAE) in patients with NS and frequent relapses treated with long-term prednisone compared to another high-risk group (obese children BMISDS > 2)Methods: Data of 30 children with S...

ea0081p624 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The action of WAY163909, central selective serotonin receptor, in obese and diabetic Wistar rats

Bogomilov Ivaylo , MIhneva Vesela , Daskalova Ivona , Nikolov Rumen , Boyadjieva Nadka

Background and aims: Obesity can be cause because of reduction in energy expenditure and /or increased caloric intake. Total calorie intake has increased in recent decades and studies on eating behavior have reported increased intake of foods rich in fats and sugars. Many regulatory pathways for food intake, including those that use serotonin as a neurotransmitter, are affected by obesity or by hypercaloric diets. Summarizing the data known so far, it can be said that reduced ...

ea0081p625 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The role of endocrine disruptors, obesity, and cytokines in PCOS

Duskova Michaela , Vitků Jana , Kolatorova Lucie , Vrbikova Jana , Vosatkova Michala , Včelak Josef , S.imkova Marketa

As genetic and environmental components contribute to the PCOS expression, we compared levels of endocrine disruptors, steroid hormones, cytokines, and metabolic parameters in twenty healthy, nine normal-weight PCOS women, and ten obese PCOS women. Steroid hormones, bisphenols (BPA, BPS, BPF, BPAF) and parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-parabens) were measured by liquid chromatography-tandem mass spectrometry. Differences between the groups were assessed using ...

ea0081p626 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

MODY 6: To be, or not to be, that is the question

Lopes Leonor , Roque Catarina , Bello Carlos , Limbert Maria Clotilde , Sequeira Duarte Joao

Introduction: Maturity-Onset Diabetes of the Young (MODY) is a rare cause of Diabetes Mellitus (<5%), resulting from autosomal dominant monogenic defects.NEUROD1 gene is expressed in pancreatic and neuronal cells, being associated with MODY type 6. Mutations in NEUROD1 gene are reported in 20 families worldwide to date. Heterozygous variant c.616C>A, p.(His206Asn) has never been described.Case Report: The authors report a c...

ea0081p627 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Anxio-depressive disorders in diabetic pregnant women on the circumstances of the COVID 19 pandemic

Charkaoui Sara , Salma Bensbaa , El Aziz Siham , Essabah Haraj Nassim , Chadli Asma

Introduction: The COVID 19 pandemic is causing a considerable degree of fear and concern among the general population. In diabetic pregnant women, this risk is even higher given the physiological and psychological changes that occur during pregnancy.Goal of the study: To evaluate the prevalence and risk factors for the onset of anxiety-depressive disorders in pregnant women with diabetes during the COVID 19 pandemic in comparison with those followed outs...

ea0081p628 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Type 1 diabetes and autoimmune diseases

Dalhoum Meriam , Ali Zohra Hadj , Bani Ines , Htira Yosra , Mami Faika Ben

Introduction: Type 1 diabetes (T1DM) is an autoimmune disease in 90% of cases and is frequently accompanied by other autoimmune diseases.Objective: To assess the frequency of autoimmune diseases in type 1 diabetics and study the particularities of this association.Patients and Method: This is a retrospective study including 120 type 1 diabetic patients hospitalized in department C of the National Institute of Nutrition in Tunis.</p...

ea0081p629 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Deep soft tissue masses as a manifestation of type 2 diabetes

da Costa Cristiana Gomes , Jacome Morgado Francisca , Vale Sonia

Introduction: Xanthomas are defined as aggregates of lipid-laden histiocytes. They are generally present in superficial soft tissues such as skin and subcutis but can occasionally involve deep soft tissues. Xanthomas are classically associated with hyperlipidemia, that can be primary or secondary to numerous disorders such as diabetes. This case highlights an atypical manifestation of T2D.Case report: A 61-year-old women was referred to our endocrinology...

ea0081p630 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Dylipidemia in type 1 diabetic patients

Bani Ines , Hadj Ali Zohra , Dalhoum Meriam , Htira Yosra , Ben Mami Feika

Introduction: Dyslipidemia in type 1 diabetic patients is a frequent situation and seems to be a risk factor for the occurrence of degenerative complications. The aim of this study is to evaluate the lipid profile of type 1 diabetic patients and to study the relationship between dyslipedmia and the occurrence of degenerative complications.Method: This is a retrospective study conducted at the National Nutrition Institute of Tunis including 110 diabetic p...

ea0081p631 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Predictive factors of glycaemic control in type 2 diabetic patients during the COVID-19 crisis

Grassa Anis , Sliman Chayma Bel Hadj , Terzi Ameni , Khessairi Nadia , Yazidi Meriem , Oueslati Ibtissem , Chihaoui Melika

Introduction: Glycaemic control is still difficult to achieve despite advances in the pharmacotherapy of type 2 diabetes. Moreover, the COVID-19 crisis led to a disruption in medical consultations and in the access to medications. The aim of our study was to identify factors associated with poor glycaemic control in Tunisian type 2 diabetic patients during the COVID-19 crisis.Methods: This is a cross-sectional study, carried out in December 2021, on type...

ea0081p632 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Assessment of glycaemic control in type 2 diabetic patients before and during the COVID-19 crisis

Hadj Sliman Chayma Bel , Grassa Anis , Terzi Ameni , Khessairi Nadia , Chaker Fatma , Oueslati Ibtissem , Chihaoui Melika

Introduction: Chronic hyperglycemia in type 2 diabetic patients is associated with an increased risk of micro and macrovascular complications. Therefore, glycemic control is the cornerstone of its management. The aim of this study was to evaluate glycemic control in patients with type 2 diabetes before and during COVID-19 crisis.Methods: A cross-sectional study was conducted during December 2021, in the outpatient clinic of the department of endocrinolog...

ea0081p633 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metabolic emergencies during the month of Ramadan

Steve Kamgain Simeu Lionel , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Fasting in the month of Ramadan is one of the pillars of Islam. The diabetic subject, whether he practices it or not, if not prepared expose him to acute complications. The objective of our study was to determine the frequency of occurrence of acute complications during the month of Ramadan.Objectives: To establish the epidemiological profile of diabetics seen in the emergency room during the month of Ramadan. Determine the frequency of occ...

ea0081p634 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Determinants and consequences of nonadherence among patients with type-2-diabetes

Raun Hansen Caroline , Wodschouw Helena Zander , Perrild Hans , Moller Christensen Tomas , Jorgensen Torben , Zander Mette

Objective: To determine the cumulative incidence of nonadherent patients with type-2-diabetes from an outpatient clinic, and to examine determinants and consequences of premature discharge.Research design and methods: A cohort comprising patients with type-2-diabetes referred to a Diabetes Clinic from 2009-2012 was assessed. Patients were categorized as nonadherent if discharged within two years of referral due to nonattendance and/or nonadherence to med...

ea0081p635 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The importance of hepatocyte STAT5b, glucokinase and ChREBP in GH receptor-mediated regulation of steatosis and de novo lipogenesis is dependent on the nutritional state

Vazquez-Borrego Mari C. , Del Rio-Moreno Mercedes , Wnek Magdalena , Mahmood Mariyah , Cordoba-Chacon Jose , Puchowicz Michelle , Kineman Rhonda

Fatty liver (steatosis) can progress to non-alcoholic fatty liver disease, increasing the risk of diabetes and cardiovascular disease. Growth hormone (GH) deficiency is associated with steatosis, while raising GH reduces steatosis. To date it remains to be determined how GH mediates this hepato-protective effect. To investigate the hepatocyte-specific actions of GH, a mouse model of adult-onset hepatocyte-specific GH receptor knockdown (aHepGHRkd) was generated by treating adu...