Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Poster Presentations


ea0081p245 | Late-Breaking | ECE2022

Recalculating renin and aldosterone to improve specificity in the diagnosis of primary aldosteronism

Doyle Luc , Okiro Julie , Sarwani Aysha , Troy Michael , Ansari Yousef , O′Donoghue Darragh , Lappin David , Mcevoy John , O'Shea Paula , Ferguson John , Conall Dennedy Michael

Rationale: The Aldosterone:Renin ratio (ARR) is commonly used for patients fulfilling screening criteria for primary hyperaldosteronism (PA), followed by confirmatory testing. Reference intervals for interpretation of the ARR vary in accordance with local population and assay 1. While ARR provides high sensitivity for PA, this is compromised by low specificity, further compounded by medication interference. However, additional variables may improve the specificity of ARR as a ...

ea0081p246 | Late-Breaking | ECE2022

Pituitary -adrenal axis insufficiency among hemodialysis patients

Bel-Ange Anat , Fux Daniel , Zelnik Yovel Dana , Koren Ronit , Beberashvili Ilia , Benbassat Carlos , Koren Shlomit

Background: The diagnosis of hypocortisolism is challenging in hemodialysis (HD) patients due to shared clinical features between renal failure and cortisol deficiency. We hypothesize that in a significant percentage of HD patients we miss cortisol deficiency.Methods: A prospective cohort of 56 end stage kidney disease patients on maintenance HD treatment (mean age 65.3±13.1, females 80 %) was studied. Low dose (1 mg) adrenocorticotropic hormone (AC...

ea0081p247 | Late-Breaking | ECE2022

Long-term mortality and excess mortality after hip fracture in the main urban area of Romania

Dobre Ramona , Ruzandra Poiana Ioana , Alexandru Niculescu Dan , Cirstoiu Catalin , Popescu Gheorghe , Poiana Catalina

Background: Excess mortality after hip fracture remains a problem of public health concern. Until present, for Romania no data is available regarding long term mortality rate and excess mortality after hip fracture. We aimed to evaluate the mortality rate 3 years after hip fracture and also standardized mortality rates of osteoporotic hip fracture in the capital city of Romania and suburban area.Methods: we collected data from over 98 % of fractures admi...

ea0081p248 | Late-Breaking | ECE2022

The differences between normocalcemic and hypercalcemic primary hyperparathyroidism: a tertiary center′s experience

Kalogeris Nikolaos , Papanikola Nektaria , Herolidi Eleni , Palioura Eleni , Papanikolaou Vasiliki , Loi Vasiliki , Vryonidou Andromahi

Introduction: Normocalcemic Primary Hyperparathyroidism is today considered a variant of Primary Hyperparathyroidism. It is characterized by persistently normal calcium levels and increased levels of parathyroid hormone, after the exclusion of other causes of secondary hyperparathyroidism. We aimed to compare clinical, biochemical and imaging data from patients with normocalcemic and hypercalcemic primary hyperparathyroidism. Methods: This is a retrospec...

ea0081p249 | Late-Breaking | ECE2022

Glycogen hepatopathy - a case series

Sharma Bhavna , Baslas Rohit , Sharif Amar , Hui Elaine

Glycogen Hepatopathy (GH) was initially described in 1930 by Pierre Mauriac. 90 years later, GH remains underrecognized in adults. The clinical or radiological characterization of GH is difficult, further compounded by lack of widespread literature. We present two cases of GH characterized by recurrent lactatemia and transient liver function and radiological abnormalities.• 19 years old male with Type 1 diabetes admitted with nausea and vomiting. pH...

ea0081p250 | Late-Breaking | ECE2022

Metabolic parameters in type 2 diabetic patients with positive Candida cultures

Radojkovic Danijela , Radenković Saša , Ćirić Vojislav , Radojkovic Milan , Pesic Stankovic Jana , Curkovic Sanja , Kostic Sonja

Introduction: The gut microbiota plays an important role in host metabolism, immunity, digestibility and even a behavior. Candida spec. is common resident of the gastrointestinal tract and integral part of the microbiota. Number of 101 to 103 fungal cells per g stool are considered as normal range. However, when mucosal surface is disrupted or host immunity is compromised, life-threatening invasive infection can ensue.Objec...

ea0081p251 | Late-Breaking | ECE2022

Polyglandular autoimmune syndrome in the elderly: a case report

Suresh Sindhuja , Kaplan Felicity , Cruickshank Alastair

Polyglandular autoimmune syndrome (PAS) is characterised by the coexistence of two or more autoimmune mediated disorders. While the pathophysiology remains poorly understood, environmental triggers and genetic susceptibility are thought to contribute to the dysregulated immune response. PAS has been classified into three main subgroups: Type 1 is seen in the paediatric population while types 2 and 3 are found in adults with autoimmune thyroid disease and insulin-requiring diab...

ea0081p252 | Late-Breaking | ECE2022

Immunotherapy induced hypopituitarism including hypogonadism in patient with previous PCOS: call for early detection and endocrine work-up

Tiemeier Gesa , Sharma Bhavna , Rahman Mushtaqur , Qureshi Asjid , Garg Ranjna

Background: Immune checkpoint inhibitors are now commonly used in melanoma, renal cell carcinoma and non-small cell lung cancers. Patients on immune check point inhibitors experience at least one type of immune related adverse event(irAEs) which can occur even after discontinuation of therapy. Endocrine toxicities are commonly reported irAE′s and tend to be irreversible. The most frequently recognized endocrine complications include thyroid dysfunction (30%) hypophysitis...

ea0081p253 | Late-Breaking | ECE2022

Central diabetes insipidus from a patients′ perspective – from management to psychological co-morbidities and re-naming of the condition

Atila Cihan , Loughrey Ben , Garrahy Aoife , Winzeler Bettina , Refardt Julie , Gildroy Patricia , Pal Aparna , Hamza Malak , Thompson Chris , Verbalis Joseph , Hunter Steven , Sherlock Mark , J Levy Miles , Karavitaki Niki , Newell-Price John , Wass John , Christ-Crain Mirjam

Background: Central diabetes insipidus (cDI), a rare neuroendocrine condition affecting 1 in 25.000, is characterized by deficiency of arginine vasopressin. Data about treatment-related side effects, psychological co-morbidities, and incidence of wrong management due to confusion with diabetes mellitus are scarce and limited to small studies or case series. Furthermore, increasing interest has arisen on a potential need for re-naming the condition.<p class="abstex...

ea0081p254 | Late-Breaking | ECE2022

Facial phenotype changes and its impact in Quality of Life of acromegaly patients

Ferrer Laura , Antonia Martinez-Momblan Maria , Marques-Pamies Montse , vazquez Federico , Soldevila Berta , Ciriza Raquel , Valassi Elena , Puig-Domingo Manel

Acromegaly is a rare disease usually diagnosed late in disease evolution. It implies for skeletal changes of most flat bones including those of the skull. Consequently, a progressive facial disfiguration occurs at slow velocity of irreversible nature. Even after curation most of these changes stay for the whole life of the patient.Aim: to study the potential relationship between disfiguring facial modifications and psychosocial and Quality of Life (QoL) ...

ea0081p255 | Late-Breaking | ECE2022

Cushing syndrome in older women: age-related differences in disease origin and clinical manifestations

Akirov Amit , Shimon Ilan , Yosi Manisterski , Aviran-Barak Nirit , Nadler Varda , Alboim Sandra , Tsvetov Gloria , Hirsch Dania

Background: Adrenocorticotropic hormone (ACTH)-producing pituitary adenoma is the most common cause of endogenous Cushing syndrome (CS), but the relative proportion of adrenal causes of CS is rising. Limited data are available on the clinical manifestations and cause of CS in older women.Objective: Determine the clinical presentation, biochemical profile, and cause of CS in women 65 years of age and older, compared with younger patients with CS.<p cl...

ea0081p256 | Late-Breaking | ECE2022

Hobnail variant of papillary thyroid carcinoma, a systematic review and meta-analysis

Spyroglou Ariadni , Kostopoulos George , Bramis Konstantinos , Tseleni Sofia , Toulis Konstantinos , Mastorakos George , Konstadoulakis Manousos , Vamvakidis Kyriakos , Alexandraki Krystallenia

Background: Although papillary thyroid carcinoma (PTC) is considered to have an excellent prognosis, some more aggressive variants have been identified that show reduced overall survival rates. Besides from the diffuse sclerosing, tall cell, columnar cell, and solid variant, the hobnail variant was newly recognized as one of these aggressive forms, affecting recurrence, metastasis, and overall survival rates.Methods: We performed a systematic review and ...

ea0081p257 | Late-Breaking | ECE2022

Retrospective assessment of malignant thyroid nodules in a group of children and adolescents according to BTA U classification and ACR TI-RADS ultrasound-based risk stratification system in combination with elastography

Bossowski Artur , Borysewicz-Sanczyk Hanna , Sawicka Beata , Bossowski Filip , Karny Agata , Rusak Aleksandra , Dzieciol Janusz

The risk of malignancy in thyroid nodules correlates with the presence of ultrasound features. In adults, ultrasound risk-classification systems have been proposed to indicate the need for further invasive diagnosis. Furthermore, elastography has been shown to support differential diagnosis of thyroid nodules. The purpose of our study was to assess the application of the American Thyroid Association (ATA) and British Thyroid Association (BTA) ultrasound risk-classification sys...

ea0081p258 | Late-Breaking | ECE2022

Discordant thyroid function tests following Ibrutinib therapy

Yung Zhuang Choo Alwyn , Jayaweera Jayamalee

Background: Tyrosine kinase inhibitors (TKI) are a chemotherapeutic group which include drugs known to cause thyroid dysfunction such as axitinib, imatinib, pazopanib, sorafenib, and sunitinib. However, reports of TKI-Ibrutinib causing thyroid dysfunction are scarce. Although several hypotheses have been proposed to explain TKI-associated thyroid dysfunction there is no clear guidance on how to manage this situation.Case: 86-year-old lady was referred to...

ea0081p503 | Late-Breaking | ECE2022

Salivary free cortisol and serum DHEA-sulfate measurements with cosyntropin stimulation improve accuracy of secondary adrenal insufficiency diagnosis in pregnancy

B Humrickhouse Ashley , Y Peltsverger Maya

Background: Diagnosis of secondary adrenal insufficiency (SAI) during pregnancy is challenging due to physiological adaptations and progressive increase of cortisol level throughout the pregnancy (1). The 250-mg standard ACTH stimulation test (CST) is recommended for evaluation of adrenal hypofunction in pregnancy however, measurement of serum cortisol (SC) maybe misleading in patients with partial SAI. Furthermore, utility of salivary free cortisol (SaFC) (2) and serum DHEA-s...

ea0081p504 | Late-Breaking | ECE2022

Adrenal incidentaloma, single center clinical experience

Turan Erdogan Beril , Evranos Ogmen Berna , Keskin Caglar , FAKI Sevgul , Aydin Cevdet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Backgorund: Adrenal incidentalomas (AI) are lesions discovered incidentally on imaging without clinical symptoms or examination findings. AI can produce hormones in 5-30% of cases. Autonomic cortisol secretion (ACS) is the most common of these. Although ACS is asymptomatic, it increases the risk of metabolic disorders.Methods: Patients aged<18 years with adrenal adenoma and upper abdominal MRI who presented and were examined in the endocrinology outp...

ea0081p505 | Late-Breaking | ECE2022

Primary hyperparathyroidism, familial hypocalciuric hypercalcaemia or both?

Kapoor Ashutosh , Sharma Bhavna , Sriranganathan Danujan , Tolley Neil , Dimarco Aimee , Rahman Mushtaqur

Introduction: Primary hyperparathyroidism (PHPT) is an endocrine condition in which autonomous excessive secretion of parathyroid hormone (PTH) results in hypercalcaemia. In approximately 80% of cases the aetiology is due to a single parathyroid adenoma, the remainder are due to hyperplasia of more than one gland. Familial Hypocalciuric Hypercalcaemia (FHH) is an autosomal dominant, inactivating mutation of the calcium-sensing receptor, causing a right-shift in the concentrati...

ea0081p506 | Late-Breaking | ECE2022

Initial results and patient satisfaction with the new oral formulation of semaglutide

Martinez Martin Francisco Javier , Kuzior Agnieszka , Arnas-Leon Claudia , Fernandez-Trujillo-Comenge Paula , Quintana-Arroyo Sara , Acosta-Calero Carmen , Delia Santana-Suarez Ana , Gonzalez-Diaz Paula , Hernandez-Lazaro Alba , de Leon-Durango Ricardo

Introduction: Oral semaglutide has been available in the Spanish market since November 2021. This new formulation has broken the self-injection barrier, and may enhance patient satisfaction.Methods: Retrospective review of the patients′ records and presential or telephonic interviews. All patients expressed their consent for the anonymous processing of their data. Numeric data are given as mean + s.d; paired t-test was used for comparison. Satisfac...

ea0081p507 | Late-Breaking | ECE2022

Insights into the early use of oral semaglutide in routine clinical practice

Saboo Bharat

Introduction: Oral semaglutide (Rybelsus; Novo Nordisk) is the first glucagon-like peptide-1 receptor agonist (GLP-1 RA) developed for oral administration for the treatment of type 2 diabetes (T2D), and it has been approved by the US Food and Drug Administration and the European Medicines Agency. The efficacy and safety of oral semaglutide were assessed in the (PIONEER) program.Aim: The purpose of this study was to investigate the initial patterns of rou...

ea0081p508 | Late-Breaking | ECE2022

In Individuals with obesity, resting energy expenditure does not decrease after weight loss with GLP-1 agonist liraglutide

Mohseni Mostafa , Welling Mila , E.H. Meeusen Renate , G.C.L.M. Broeders Wietske , Valk Eline van der , van Rossum Elisabeth

Background: Obesity (BMI< 30 kg/m2) is a chronic and progressive disease, that is associated with many co-morbidities such as cardiovascular and psychiatric diseases, cancer, and arthritis. Lifestyle interventions are the cornerstone of obesity treatment, but when ineffective, anti-obesity pharmacotherapy could be added. In recent years, several anti-obesity agents have been approved, such as the glucagon-like peptide -1 (GLP-1) analogue liraglutide. Liraglutide...

ea0081p509 | Late-Breaking | ECE2022

Neuroprotective properties of GLP-1 receptor agonists and SGLT-2 inhibitors in experimental stroke

Simanenkova Anna , Timkina Natalya , Karonova Tatiana , Tikhomirova Polina , Gagiev Alexandr , Radugin Fedor , Vlasov Timur

Background and aims: The most outstanding cardioprotective potential has been demonstrated for GLP-1 receptor agonists (GLP-1RA) and SGLT-2 inhibitors (SGLT-2i). But only long-acting GLP-1RA dulaglutide (DULA) and semaglutide decrease stroke incidence, while data concerning the influence of any drug on stroke severity are lack. At the same time, ischemic stroke remains one of the leading causes of death in type 2 diabetes mellitus (DM2). The aim of our study was to investigate...

ea0081p510 | Late-Breaking | ECE2022

Suppressor of cytokine signaling-3 in pregnant females with or without hypertension: a case-control study

Ali Huma , Ali Mubeen , Farhat Sabah , Sadia Fatima Syeda

Suppression of Cytokine Signalling-3 (SOCS-3) modulates the inflammatory pathways responsible for vascular stability by playing a role in inflammatory pathway. It acts by inhibiting the activation of Janus kinase-signal transducer and activating of transcription (JAK-STAT) pathway to transmit their information into the cell nucleus. Therefore, this study aimed to estimate SOCS-3 levels in 2 nd trimester pregnant females and correlate it with blood pressure. A case control stud...

ea0081p511 | Late-Breaking | ECE2022

Silent acromegaly- a case report

Ashraf Hanaan , Mubarik Idrees

Background: Mammosomatotroph cell adenoma is rare, accounting for fewer than 2% of all pituitary adenomas and about 8% of tumors associated with acromegaly. A variety of adenomas may present with clinical signs and symptoms of GH hypersecretion including pure GH cell adenomas, mixed GH and prolactin cell adenomas, and monomorphous adenomas with primitive cells able to secrete GH and prolactin including the acidophilic stem cell adenoma and the mammosomatotroph cell adenoma. He...

ea0081p512 | Late-Breaking | ECE2022

Changes in acromegaly presentation and treatment over a three-decade period

Aagaard Charlotte , S Christophersen Amanda , Finnerup Susanne , Rosendal Christian , Vestergaard Peter , Karmisholt Jesper , H Nielsen Eigil , Dal Jakob

Objective: To study time-dependent changes in the prevalence and patient characteristics of acromegaly, as well as to access the impact of changes in treatment on disease control.Methods: A total of 107 patients with acromegaly were identified by healthcare registries and subsequently validated by patient chart review over a three-decade period (1992-2021).Results: The prevalence of acromegaly significantly increased throughout the...

ea0081p513 | Late-Breaking | ECE2022

The first reported pregnancy and birth by a patient affected by Alström Syndrome: a case report

Marozio Luca , Bertschy Gianluca , Canuto Emilie M. , Maffei Pietro , Milan Gabriella , Dassie Francesca , Cosma Stefano , Benedetto Chiara

Background: Alström Syndrome (ALMS, OMIM 203800) is an ultra-rare disease caused by autosomal recessive mutations of the ALMS1 gene (2p13). ALMS is characterized by double sensory impairment and systemic comorbidities, including hyperandrogenism in female patients. Fertility issue and conception have not been systematically studied.Case: This case report describes the pregnancy and birth by an ALMS patient with mild phenotype, characterized...

ea0081p514 | Late-Breaking | ECE2022

Superior vena cava syndrome associated with graves’ disease

Durmaz Himmet , Arifoglu Unzile , Omer Yazıcıoglu Mustafa , Sacıkara Muhammed , Nasıroglu İmga Narin , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Introduction: Goiter means that the thyroid gland is larger than the normal size for the patient’s age and gender. Some of the causes of goiter are iodine deficiency, thyroid nodules, Graves’ disease(GD). Goiter, hyperthyroidism, ophthalmopathy and dermopathy can be seen in GD. Compression symptoms due to goiter (dyspnea, dysphagia, superior vena cava syndrome) are also seen. Here, we will present a case of GD with superior vena cava syndrome.C...

ea0081p515 | Late-Breaking | ECE2022

Parathormone washout in cytology of Suspicious for Follicular Neoplasm

Durmaz Himmet , Cavnar Helvacı Burcak , Beştepe Nagihan , Aksoy Altınboğa Ayşegul , Dirikoc Ahmet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Introduction: The risk of malignancy in thyroid nodules is reported by the Bethesda system by performing fine needle aspiration biopsy (FNAB). Atypia of undetermined significance(AUS) or follicular lesion of undetermined significance(FLUS)(Bethesda 3) and suspicious for a follicular neoplasm (Bethesda 4) create uncertainty about treatment and follow-up. Molecular tests, ultrasonographic features of the nodules, and calcitonin level help us for this uncertainty. Here, we will p...

ea0081p516 | Late-Breaking | ECE2022

Myxedema coma: case report and literature review

Cassitas Mendonca Renata , Vilas Boas Laura , Cardoso da Silva Thielsen , Maranho Ribas Laura , Sohn Fagundes Tamila , Elizabeth Cesca Taciane , Paulino Ribeiro Gama Mirnaluci

Introduction: Myxedematous coma is a rare endocrine emergency that settles in the absence of appropriate treatment for hypothyroidism for a long period. The severe and chronic reduction of serum thyroid hormones culminates in the insufficiency of compensatory mechanisms that maintain the physiological homeostasis of the organism. The clinical condition is severe, commonly associated with hypoxemia, hypercapnia, hypothermia, reduced cardiac output, and altered mental status.</p...

ea0081p762 | Late-Breaking | ECE2022

Do polymorphisms of the glucocorticoid and mineralocorticoid receptors play a role in adrenal crises?

Chifu Irina , Janik Freytag , Herterich Sabine , Heike Weber , Hahner Stefanie

Introduction: Polymorphisms of the glucocorticoid (NR3C1) and mineralocorticoid receptor (NR3C2) have been linked to the regulation of HPA-axis and to glucocorticoid sensitivity. We investigated whether NR3C1 and NR3C2 polymorphisms correlate with the occurence of adrenal crises (AC) in patients with primary adrenal insufficiency (PAI).Material and methods: We investigated 100 patients with PAI (70% women, mean age 51±15 years). DNA was extracted fr...

ea0081p763 | Late-Breaking | ECE2022

Actions taken for prevention of adrenal insufficiency in adult patients who are at risk - audit report

Jayaweera Jayamalee , Sheikh Sara , Higgoda Rakitha , Kundrapu Karthayani , Jajah Bilal , Brahma Anupam

Background: Adrenal insufficiency (AI) is can be often under recognised condition in the clinical practise which can potentially result in adrenal crisis or even death if not treated properly. Identification of patients who are at risk of developing AI is important in order to take appropriate steps in minimising unwanted incidents. Objectives: Study aims to assess whether we identify patients who are at risk of AI and take recommended precautions.<p...

ea0081p764 | Late-Breaking | ECE2022

Hypertension in Pheochromocytoma and paraganglioma : Characteristics, treatment and outcomes

Derkaoui Nada , ALLA Achwak , El Amel Rania , Imane Rami , ROUF Siham , Latrech Hanane

Introduction: Pheochromocytomas and paraganglioma are neuroendocrine tumors that arise from the chromaffin cells of the adrenal medulla or originate from the autonomic nerve ganglia. Hypertension in patients with PPGL is the most frequent symptom and can be responsible of lethal cardiovascular complications. The aim of our work is to describe the clinical characteristics of hypertension in PPGL, the treatment and the outcomes after surgical treatment.Mat...

ea0081p765 | Late-Breaking | ECE2022

Multiple vertebral fractures following ibrutinib therapy in a patient with B-cell chronic lymphocytic leukemia

Andric Jelena , Ivic Marija , Jaksic Ozren , Huzjan Korunic Renata , Perovic Darko , Pandzic Jaksic Vlatka

Some hematologic malignancies might increase the risk of fractures due to intrinsic factors of the disease but also because of the treatment with steroids or chemotherapy. The direct impact of novel targeted agents on the development of osteoporosis in these patients has not been recognized yet. A 64-years old female patient with B-cell chronic lymphocytic leukemia (B-CLL) has been followed for four years with no other comorbidities. In order to measure the burden of the disea...

ea0081p766 | Late-Breaking | ECE2022

Diagnostic process in a lipodystrophic syndrome suspition, a clinical case

Ferreira Pablo , Martinez de la Cruz Paula , Miren Azkutia Uribe Echevarria Ane , Shabaka Fernandez Amir , Lois Chicharro Pablo , Carolina Doejo Marciales Sandra , Fabiola Barra Malig Solange , Garmendia Fernandez Cristina , Almodovar Ruiz Francica , Jose Gorgojo Martinez Juan

The lipodystrophic syndromes are a heterogeneous group of congenital or acquired disorders characterized by either complete or partial lack of adipose tissue with the apparent accumulation of fat in other regions of the body. Their prevalence is low and ranges from 1:200000/500000 and they usually suffer metabolic abnormalities associated with the abnormal distributition of fat such as severe insulin resistance with acantosis and diabetes, progressive liver disease along with ...

ea0081p767 | Late-Breaking | ECE2022

Correlation of adiponectin and resistin with atherogenic markers in insulin resistant and non-insulin resistant adolescent women with polycystic ovary syndrome

Atanasova Boshku Aleksandra , Ivanova Panova Daniela

Aim: To evaluate adiponectin and resistin levels and their relationship with various biochemical and metabolic and atherogenic parameters markers, as well as their correlation, and to investigate its contribution in pathogenesis of insulin resistance in cohort women with PCOS and of insulin resistance as well as in non-insulin resistant women with PCOS. Methods: This study was designed as a cross-sectional and involves 80 premenopausal women. Of these patients, 63 females have...

ea0081p768 | Late-Breaking | ECE2022

Insulin-Like Growth Factor-I might be a predictor for severe nonalcoholic fatty liver disease in morbidly obese patients

Turgut Seda , Acarer Bugun Didem , Seyit Hakan , Pamuk Naim , Pişkinpaşa Hamide , Bozkur Evin , Karabulut Mehmet , Cakır İlkay

Aim: To compare the IGF-1, metabolic and clinical parameters among the ultrasonographically classified NAFLD groups, to examine the effect of weight loss on metabolic parameters and determine the factors that may predict the NAFLD severity in morbidly obese patients who underwent bariatric surgery.Method: This descriptive cross-sectional study was conducted in 316 morbidly obese patients (250 females, 66 males). The data of patients before and 1st year a...

ea0081p769 | Late-Breaking | ECE2022

Coexistence of hypopituitarism caused by Sheehan′s syndrome and Hashimoto′s thyroiditis. A case report, review of literature.

Kermaj Marjeta , Zaimi Irsa , Guni Mirjeta , Shkurti Adela , Fureraj Thanas , Ylli Agron

Introduction: Hypopituitarism due to Sheehan′s syndrome is a rare complication and its diagnosis is often overlooked. The vast majority of people with hypothyroidism have primary hypothyroidism, often due to Hashimoto’s thyroiditis. Coexistence of hypopituitarism and primary hypothyroidism, may accelerate clinical manifestations, mainly those associated with hypothyroidism. Hashimoto′s Thyroiditis with concomitant hypopituitarism is rare but has been described...

ea0081p770 | Late-Breaking | ECE2022

A patient with acromegalic heart disease

Houssein Mehdi , Turan Kubra , Temizhan Ahmet , Tural Balsak Belma , Ali Tam Abbas , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

A 36 years of old patient was admitted to the intensive care unit of cardiology when he experienced palpitations and orthopnea. The patient’s complaints started about 2 years ago as syncope and sudden shortness of breath. Thorax CT showed pleural effusion and increased cardiothoracic index. Findings on ECHO were : Ejection fraction 35%, severe mitral regurgitation and global hypokinesia. Coronary angiogram showed a fibrocalcific plaque noted in in the distal LAD. The pati...

ea0081p771 | Late-Breaking | ECE2022

SRSF6 (Serine/arginine-Rich Splicing Factor 6) is a novel factor regulating androgen receptor signalling in prostate cancer cells

Montero-Hidalgo Antonio J. , Manuel Jimenez-Vacas Juan , de la Salud De la Rosa-Herencia Ana , Herrero-Aguayo Vicente , Gomez-Gomez Enrique , Carlos Fuentes-Fayos Antonio , David Gahete-Ortiz Manuel , Miguel Luque-Huertas Raul

Prostate cancer (PCa) represents the most diagnosed tumour pathology in developed countries among men population. The main pharmacological approach to treat this pathology is based on the blockade of the androgen receptor signalling pathway, commonly known as androgen-deprivation therapy. However, some of the patients does no longer respond to this therapy, therefore developing castration-resistant prostate cancer (CRPC), the most aggressive phenotype of this pathology, which ...

ea0081p772 | Late-Breaking | ECE2022

Thionamides-induced agranulocytosis in a patient with previous hematological disease: a case report

Sohn Fagundes Tamila , Vilas Boas Laura , Cardoso da Silva Thielsen , Maranho Ribas Laura , Cassitas Mendonca Renata , Peon Train Nicoluzzi Leticia , Roberta Bianchini Fernandes Maria , Paulino Ribeiro Gama Mirnaluci

Introduction: The treatment of thyroid diseases with thionamides can cause agranulocytosis a potentially fatal side effect. The manifestations resulting from such a condition include, in most cases, infections that, if not treated immediately, have a high risk of septicemia. Therefore, the clinical presentation includes fever of unknown origin and infections such as pneumonia, tonsillitis, and abscesses. Most patients who do not receive immediate medical intervention progress ...

ea0081p773 | Late-Breaking | ECE2022

Thyroglobulin antibodies in women with recurrent pregnancy loss: a systematic review and meta-analysis

Huisman Perrine , Krogh Jesper , Henrik Nielsen Claus , Svarre Nielsen Henriette , Feldt-Rasmussen Ulla , Bliddal Sofie

Background: Thyroid autoimmunity is the most prevalent autoimmune disorder among women of reproductive age and has been linked to pregnancy loss. In recurrent pregnancy loss (RPL), couples suffer several consecutive losses resulting in physical as well as psychological strains. Thyroid autoimmunity has been suggested as a risk factor in RPL, but most studies have focused on thyroid peroxidase antibodies (TPOAbs), not taking into account the presence of thyroglobulin antibodies...

ea0081p774 | Late-Breaking | ECE2022

Regulatory B cells involvement in autoimmune phenomena occurring in pediatric graves’ disease patients.

Bossowski Artur , Grubczak Kamil , Starosz Aleksandra , Stożek Karolina , Bossowski Filip , Moniuszko Marcin

Graves’s disease is the most common type of autoimmune hyperthyroidism. Numerous studies indicate different factors contributing to the onset of the disease. Despite years of research, the exact pathomechanism of Graves’ disease still remains unresolved, especially in the context of immune response. B cells can play a dual role in autoimmune reactions, on the one hand, as a source of autoantibody mainly targeted in the thyroid hormone receptor (TSHR) and, on the othe...